Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02112 (show subtarget assignments)	1	cloned	No	FTT1024c	56708113	yhbG	ABC transporter, ATP-binding protein [Fr...	243	Conserved; Drug target functions	Phase 3: June 2008	1JI0	34.6%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02286 (show subtarget assignments)	1	cloned	No	FTT1029	56708118	dacD	D-alanyl-D-alanine carboxypeptidase (pen...	444	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3IT9	31.1%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01857 (show subtarget assignments)	1	soluble	No	FTT1034c	56708121	ndh	NADH dehydrogenase [Francisella tularens...	420	Drug Target	Phase 3: June 2008	1XHC	21%	Francisella tularensis	Energy metabolism	Electron transport

IDP02083 (show subtarget assignments)	1	cloned	No	FTT1044c	56708131	ispB	octaprenyl-diphosphate synthase [Francis...	325	Drug Target	Phase 3: June 2008	3OYR	43.1%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02232 (show subtarget assignments)	1	expressed	No	FTT1050c	56708136	cysN	sulfate adenylate transferase subunit 1 ...	470	Drug Target	Phase 3: June 2008	1ZUN	56%	Francisella tularensis	Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo	Serine familySulfur metabolism,Purine ribonucleotide biosynthesis

IDP02227 (show subtarget assignments)	1	cloned	No	FTT1063	56708148	hemF	coproporphyrinogen III oxidase [Francise...	308	Drug Target	Phase 3: June 2008	1VJU	51.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04646 (show subtarget assignments)	1	soluble	No	FTT1085	56708168		hypothetical protein FTT_1085 [Francisel...	332	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1QXN	9.3%	Francisella tularensis

IDP02095 (show subtarget assignments)	1	in_pdb 3TNO 3TK7 3TE9 3TKF 3UPB 4E0C 3IGX	No	FTT1093c	56708176	talA	transaldolase B [Francisella tularensis ...	321	Conserved; Drug target functions	Phase 3: June 2008	3IGX	100%	Francisella tularensis	Energy metabolism	Pentose phosphate pathway

IDP02234 (show subtarget assignments)	1	cloned	No	FTT1094c	56708177		cytosol aminopeptidase family protein [F...	471	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3IJ3	41.1%	Francisella tularensis	N/A	N/A

IDP90003 (show subtarget assignments)	8	crystallized	No	FTT1103	56708183		conserved hypothetical lipoprotein	365	(Community Request)	Community Requests	3GYK	12.3%	Francisella tularensis

IDP02235 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1105c	56708184	msrA1	bifunctional methionine sulfoxide reduct...	284	Drug Target	Phase 3: June 2008	2GT3	23.2%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein modification and repair

IDP02236 (show subtarget assignments)	1	cloned	No	FTT1108	56708186		rRNA methyltransferase [Francisella tula...	250	Drug Target	Phase 3: June 2008	1IPA	29.3%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02351 (show subtarget assignments)	1	cloned	No	FTT1112c	56708190	rpoH	RNA polymerase factor sigma-32 [Francise...	292	Drug Target	Phase 3: June 2008	1IW7	25%	Francisella tularensis	Cellular processesTranscription	Adaptations to atypical conditionsTranscription factors

IDP02127 (show subtarget assignments)	1	cloned	No	FTT1116c	56708194	yajC	preprotein translocase family protein [F...	118	Conserved; Drug target functions	Phase 3: June 2008	2RDD	17.8%	Francisella tularensis	Protein fate	Protein and peptide secretion and trafficking

IDP02699 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1120c	56708198	tgt	queuine tRNA-ribosyltransferase. [Franci...	367	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1OZM	56.1%	Francisella tularensis	Protein synthesis	tRNA and rRNA base modification

IDP04647 (show subtarget assignments)	1	purified	No	FTT1127	56604696		Rhodanese-like family protein [Francisel...	252	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1YT8	18.3%	Francisella tularensis

IDP00331 (show subtarget assignments)	1	in_pdb 3RE3	Yes	FTT1128	56708205	ispF	2C-methyl-D-erythritol 2,4-cyclodiphosph...	159	Drug Target Function	Phase 2: March 2008	3RE3	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02241 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1129c	56708206		hypothetical protein FTT1129c [Francisel...	561	Drug Target	Phase 3: June 2008	1O5Z	11.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism	OtherNitrogen metabolism

IDP02255 (show subtarget assignments)	1	cloned	No	FTT1130c	56708207	cphA	cyanophycin synthetase [Francisella tula...	940	Drug Target	Phase 3: June 2008	2WTZ	13.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism	OtherNitrogen metabolism

IDP02044 (show subtarget assignments)	1	expressed	No	FTT1132c	56708208	glpQ	glycerophosphoryl diester phosphodiester...	250	Drug Target	Phase 3: June 2008	1O1Z	28%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02268 (show subtarget assignments)	1	expressed	No	FTT1133	56708209	pilB	Type IV pili nucleotide binding protein,...	592	Conserved; Drug target functions	Phase 3: June 2008	1P9R	31.1%	Francisella tularensis	Cell envelope	Surface structures

IDP02144 (show subtarget assignments)	1	cloned	No	FTT1136c	56708211		hypothetical protein FTT1136c [Francisel...	111	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP02423 (show subtarget assignments)	1	cloned	No	FTT1138	56708213	hemH	ferrochelatase [Francisella tularensis s...	333	Drug Target	Phase 3: June 2008	1HRK	27.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02424 (show subtarget assignments)	1	cloned	No	FTT1147c	56708218	dfp	4'-phosphopantothenoylcysteine decarboxy...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	19.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02430 (show subtarget assignments)	1	expressed	No	FTT1151c	56708222		hypothetical protein FTT1151c [Francisel...	95	Drug Target	Phase 3: June 2008	2JR5	25.3%	Francisella tularensis	Unknown function	General

IDP92249 (show subtarget assignments)	8	selected	No	FTT_1152	56604715		hypothetical protein [Francisella tulare...	127	virulence/pathogenesis / We recently described FTN_1133/FTL_0803/FTT_1152 as an important virulence facto...	Community Requests			Francisella tularensis

IDP02414 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1154c	56708225	aroB	3-dehydroquinate synthase [Francisella t...	359	Conserved; Drug target functions	Phase 3: June 2008	3OKF	44.3%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP02271 (show subtarget assignments)	1	crystallized	No	FTT1155c	56708226	aroK	shikimate kinase I [Francisella tularens...	176	Conserved; Drug target functions	Phase 3: June 2008	1KAG	58%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP02275 (show subtarget assignments)	1	cloned	No	FTT1158c	56708229		Type IV pili glycosylation protein [Fran...	198	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008			Francisella tularensis	Cell envelopeCellular processes	Surface structuresPathogenesis,Cell adhesion

IDP02287 (show subtarget assignments)	1	purified	No	FTT1161	56708232	adk	adenylate kinase [Francisella tularensis...	218	Drug Target	Phase 3: June 2008	1AKE	56.4%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP02279 (show subtarget assignments)	1	crystallized	No	FTT1164c	56708234	era	GTP-binding protein Era [Francisella tul...	297	Drug Target	Phase 3: June 2008	1EGA	48.5%	Francisella tularensis	Cellular processesRegulatory functions	Cell divisionRNA interactions

IDP00336 (show subtarget assignments)	1	cloned	No	FTT1186	56708252	smpB	SsrA-binding protein	157	Drug Target Function	Phase 2: March 2008	1P6V	48.4%	Francisella tularensis	Protein synthesis	Other

IDP00335 (show subtarget assignments)	1	in_pdb 3OUT	No	FTT1197c	56708260	murI	glutamate racemase	265	Drug Target Function	Phase 2: March 2008	3OUT	100%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02119 (show subtarget assignments)	1	in_pdb 3KWM	No	FTT1208	56708271	rpiA	ribose-5-phosphate isomerase A [Francise...	224	Conserved; Drug target functions	Phase 3: June 2008	3KWM	100%	Francisella tularensis	Energy metabolism	Pentose phosphate pathway

IDP02295 (show subtarget assignments)	1	cloned	No	FTT1212c	56708274	gloA	lactoylglutathione lyase [Francisella tu...	127	Drug Target	Phase 3: June 2008	1F9Z	56.7%	Francisella tularensis	Energy metabolism	Other

IDP02345 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1220	56708282		5-formyltetrahydroformate cycloligase fa...	182	Drug Target	Phase 3: June 2008	2JCB	28.6%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02126 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1221	56708283		hypothetical protein FTT1221 [Francisell...	88	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelopeRegulatory functions,Unknown function	Biosynthesis and degradation of murein sacculus and peptidoglycanOther,General

IDP02437 (show subtarget assignments)	1	expressed	No	FTT1226c	56708288	iscS	cysteine desulfarase [Francisella tulare...	391	Drug Target	Phase 3: June 2008	1P3W	41.9%	Francisella tularensis	Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers	Pyruvate familyOther

IDP02714 (show subtarget assignments)	1	purified	No	FTT1231	56708293	mesJ	PP-loop family protein [Francisella tula...	398	Conserved; Drug target functions	Phase 3: June 2008	1NI5	27.3%	Francisella tularensis	Cellular processes	Cell division

IDP02297 (show subtarget assignments)	1	cloned	No	FTT1235c	56708297	lpcC	glycosyl transferase group 1 family prot...	354	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2GEJ	17.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02228 (show subtarget assignments)	1	cloned	No	FTT1240c	56708302		hypothetical protein FTT1240c [Francisel...	182	Drug Target	Phase 3: June 2008	2P0T	32.4%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02434 (show subtarget assignments)	1	soluble	No	FTT1241	56708303	glyA	serine hydroxymethyltransferase [Francis...	417	Drug Target	Phase 3: June 2008	3GBX	67.1%	Francisella tularensis	Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin	Serine familyFolic acid,Purine ribonucleotide biosynthesis

IDP04648 (show subtarget assignments)	1	selected	No	FTT1245	56708307	rluD	ribosomal large subunit pseudouridine sy...	332	drug target; conserved gene;	Phase 4: April 2009	1V9F	43.1%	Francisella tularensis	Protein synthesis	tRNA and rRNA base modification

IDP02457 (show subtarget assignments)	1	expressed	No	FTT1248	56708310		ABC transporter, ATP-binding protein [Fr...	253	Drug Target	Phase 3: June 2008	1B0U	31.1%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02301 (show subtarget assignments)	1	cloned	No	FTT1249	56708311		cell entry (mce) related family protein ...	241	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02379 (show subtarget assignments)	1	expressed	No	FTT1257	56708319	emrA1	HlyD family secretion protein [Francisel...	340	Conserved; Drug target functions	Phase 3: June 2008	4DK0	22.1%	Francisella tularensis	Cellular processesTransport and binding proteins	Toxin production and resistanceOther

IDP02416 (show subtarget assignments)	1	purified	No	FTT1259	56708321	nadE	NH(3)-dependent NAD(+) synthetase [Franc...	249	Conserved; Drug target functions	Phase 3: June 2008	3FIU	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP02393 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1269c	56708329	dnaK	heat shock protein DnaK [Francisella tul...	642	Conserved; Drug target functions	Phase 3: June 2008	2KHO	71.3%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP02360 (show subtarget assignments)	1	soluble	No	FTT1270c	56708330	grpE	heat shock protein GrpE [Francisella tul...	195	Conserved; Drug target functions	Phase 3: June 2008	1DKG	36.9%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP91216 (show subtarget assignments)	1	crystallized	No	FTT_1275	56708335	mglA	macrophage growth locus, subunit A [Fran...	205	potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3MDK	25.4%	Francisella tularensis

IDP04649 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1283	56708343	trmE	tRNA modification GTPase TrmE [Francisel...	450	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XZP	36.1%	Francisella tularensis	Protein synthesis	tRNA and rRNA base modification

IDP02497 (show subtarget assignments)	1	cloned	No	FTT1287	56708346	cbs	cystathionine beta-synthase (cystein syn...	307	Conserved; Drug target functions	Phase 3: June 2008	4AEC	33.2%	Francisella tularensis	Amino acid biosynthesis	Serine family

IDP02356 (show subtarget assignments)	1	cloned	No	FTT1296	56708355	ubiE	menaquinone biosynthesis methyltransfera...	250	Conserved; Drug target functions	Phase 3: June 2008	2AVN	20%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02507 (show subtarget assignments)	1	cloned	No	FTT1298	56708357	ubiB	2-polyprenylphenol 6-hydroxylase [Franci...	552	Conserved; Drug target functions	Phase 3: June 2008			Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04650 (show subtarget assignments)	1	expressed	No	FTT1302	56708360		hypothetical protein FTT_1302 [Francisel...	276	drug target; conserved gene;	Phase 4: April 2009	3GBP	88.3%	Francisella tularensis

IDP02387 (show subtarget assignments)	1	expressed	No	FTT1304c	56708362	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	282	Conserved; Drug target functions	Phase 3: June 2008	3TX1	33.7%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00341 (show subtarget assignments)	1	cloned	No	FTT1305c	56708363	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	444	Drug Target Function	Phase 2: March 2008	3SG1	32.7%	Francisella tularensis

IDP02738 (show subtarget assignments)	1	cloned	No	FTT1310c	56708367	hflB	ATP-dependent metalloprotease [Francisel...	638	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2DHR	39.3%	Francisella tularensis	N/A	N/A

IDP02341 (show subtarget assignments)	1	cloned	No	FTT1313c	56708370	greA	transcriptional elongation factor [Franc...	160	Conserved; Drug target functions	Phase 3: June 2008	1GRJ	63.1%	Francisella tularensis	Regulatory functions	Other

IDP02733 (show subtarget assignments)	1	in_pdb 3M5P 3Q7I 3Q88 3LJK	Yes	FTT1315c	56708372	pgi	glucose-6-phosphate isomerase [Francisel...	540	Conserved; Drug target functions	Phase 3: June 2008	3LJK	99.8%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02398 (show subtarget assignments)	1	in_pdb 3PEI	Yes	FTT1318c	56708375	pepA	cytosol aminopeptidase [Francisella tula...	479	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3PEI	100%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02739 (show subtarget assignments)	1	purified	No	FTT1321	56708378		peptidase M16 family protein [Francisell...	417	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3AMI	31.2%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02701 (show subtarget assignments)	1	soluble	No	FTT1322	56708379		peptidase M16 family protein [Francisell...	407	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3GWB	29%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02397 (show subtarget assignments)	1	purified	No	FTT1326	56708383	udp	uridine phosphorylase [Francisella tular...	267	Drug Target	Phase 3: June 2008	3O6V	43.1%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02352 (show subtarget assignments)	1	cloned	No	FTT1334c	56708390		hypothetical protein FTT1334c [Francisel...	169	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP90000 (show subtarget assignments)	8	cloned	No	FTT1352	56708408		hypothetical protein FTT1352	383	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Francisella tularensis

IDP02755 (show subtarget assignments)	1	expressed	No	FTT1365c	56708418	fbaB	fructose-1,6-bisphosphate aldolase [Fran...	354	Conserved; Drug target functions	Phase 3: June 2008	3GAK	46.6%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02363 (show subtarget assignments)	1	purified	No	FTT1366c	56708419	pyk	pyruvate kinase [Francisella tularensis ...	478	Conserved; Drug target functions	Phase 3: June 2008	1E0U	39.5%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02760 (show subtarget assignments)	1	in_pdb 4EHJ	No	FTT1367c	56708420	pgk	phosphogylcerate kinase [Francisella tul...	392	Conserved; Drug target functions	Phase 3: June 2008	4EHJ	100%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02310 (show subtarget assignments)	1	in_pdb 3KOM	No	FTT1369c	56708422	tktA	transketolase [Francisella tularensis su...	663	Conserved; Drug target functions	Phase 3: June 2008	3KOM	99.7%	Francisella tularensis	Energy metabolism	Pentose phosphate pathway

IDP00334 (show subtarget assignments)	1	in_pdb 3LYL	No	FTT1375	56708428	fabG	3-oxoacyl-(acyl-carrier-protein) reducta...	247	Drug Target Function	Phase 2: March 2008	3LYL	100%	Francisella tularensis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02595 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1384c	56708433		acetyltransferase [Francisella tularensi...	163	Drug Target	Phase 3: June 2008			Francisella tularensis	Central intermediary metabolismUnknown function	OtherEnzymes of unknown specificity

IDP02773 (show subtarget assignments)	1	crystallized	No	FTT1389	56708438	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	264	Conserved; Drug target functions	Phase 3: June 2008	1O66	41.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02771 (show subtarget assignments)	1	in_pdb 3N8H 3QTT	Yes	FTT1390	56708439	panC	pantoate-beta-alanine ligase [Francisell...	261	Conserved; Drug target functions	Phase 3: June 2008	3N8H	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02730 (show subtarget assignments)	1	in_pdb 3OUG	Yes	FTT1391	56708440	panD	aspartate alpha-decarboxylase [Francisel...	111	Drug Target	Phase 3: June 2008	3OUG	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02308 (show subtarget assignments)	1	expressed	No	FTT1400c	56708448		hypothetical protein FTT1400c [Francisel...	128	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP02779 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1405c	56708453	gloB	hydroxyacylglutathione hydrolase [Franci...	252	Conserved; Drug target functions	Phase 3: June 2008	2QED	34.1%	Francisella tularensis	Energy metabolism	Other

IDP02585 (show subtarget assignments)	1	purified	No	FTT1416c	56708463		lipoprotein [Francisella tularensis subs...	137	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP04651 (show subtarget assignments)	1	cloned	No	FTT1417	56708464		carbon-nitrogen hydrolase [Francisella t...	261	drug target; conserved gene;	Phase 4: April 2009	2E11	34.3%	Francisella tularensis

IDP04652 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1432c	56708477	ppnK	inorganic phosphate/ATP-NAD kinase [Fran...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2AN1	41.6%	Francisella tularensis

IDP02293 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1445	56708487	trxA1	thioredoxin [Francisella tularensis subs...	107	Conserved; Drug target functions	Phase 3: June 2008	2H71	50.5%	Francisella tularensis	Energy metabolism	Electron transport

IDP02419 (show subtarget assignments)	1	purified	No	FTT1447c	56708489	manB	phosphomannomutase [Francisella tularens...	494	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2F7L	25.7%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02792 (show subtarget assignments)	1	cloned	No	FTT1461c	56708502	wbtD	galacturonosyl transferase [Francisella ...	363	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2GEJ	18.5%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02162 (show subtarget assignments)	1	cloned	No	FTT1463c	56708504	wbtB	galactosyl transferase [Francisella tula...	205	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP02462 (show subtarget assignments)	1	expressed	No	FTT1467c	56708507	nadB	L-aspartate oxidase [Francisella tularen...	495	Conserved; Drug target functions	Phase 3: June 2008	1CHU	38.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP91059 (show subtarget assignments)	8	soluble	No	FTT_1472c	56708512	ppiC	peptidyl-prolyl cis-trans isomerase [Fra...	92	virulence/pathogenesis / Gene encodes a SurA orthologue which has shown to be important for virulence in ...	Community Requests	1JNS	47.8%	Francisella tularensis

IDP02450 (show subtarget assignments)	1	expressed	No	FTT1475	56708515	galT	galactose-1-phosphate uridylyltransferas...	341	Drug Target	Phase 3: June 2008	1HXQ	51.6%	Francisella tularensis	Energy metabolism	Sugars

IDP02441 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1478c	56708518	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	250	Drug Target	Phase 3: June 2008	3TQD	51.2%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02812 (show subtarget assignments)	1	cloned	No	FTT1484c	56708523	aceF	dihydrolipoamide acetyltransferase [Fran...	631	Conserved; Drug target functions	Phase 3: June 2008	3DUF	26%	Francisella tularensis	Energy metabolism	Pyruvate dehydrogenase

IDP00333 (show subtarget assignments)	1	crystallized	No	FTT1487	56708526	coaE	Dephospho-CoA kinase	204	Drug Target Function	Phase 2: March 2008	1JJV	31.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04653 (show subtarget assignments)	1	expressed	No	FTT1503	56708541	xerC	integrase/recombinase XerC [Francisella ...	292	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A0P	34.6%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP02827 (show subtarget assignments)	1	cloned	No	FTT1508c	56708546	relA	GTP pyrophosphokinase [Francisella tular...	647	Drug Target	Phase 3: June 2008	1VJ7	20.1%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP01609 (show subtarget assignments)	1	crystallized	No	FTT1512c	56708550	dnaJ1	heat shock protein, hsp40 [Francisella t...	308	Conserved; Drug target functions	Phase 3: June 2008	3LZ8	34.2%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP02832 (show subtarget assignments)	1	expressed	No	FTT1518	56708554	ogt	methylated-DNA--protein-cysteine methylt...	190	Conserved; Drug target functions	Phase 3: June 2008	1SFE	28.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy	Heme, porphyrin, and cobalaminOther,tRNA and rRNA base modification

IDP02790 (show subtarget assignments)	1	cloned	No	FTT1525c	56708559		hypothetical protein FTT1525c [Francisel...	295	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04654 (show subtarget assignments)	1	purified	No	FTT1526c	56708560	idh	isocitrate dehydrogenase [Francisella tu...	747	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1ITW	62.7%	Francisella tularensis

IDP04044 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1530	56708564	fadB/acbP	fusion product of 3-hydroxacyl-CoA dehyd...	898	drug target; conserved gene;	Phase 4: April 2009	3K6J	11.7%	Francisella tularensis	Fatty acid and phospholipid metabolism	Degradation

IDP04655 (show subtarget assignments)	1	soluble	No	FTT1531	56708565	fadA	acetyl-CoA acetyltransferase [Francisell...	395	drug target; conserved gene;	Phase 4: April 2009	1ULQ	45.7%	Francisella tularensis	Fatty acid and phospholipid metabolism	Other

IDP02262 (show subtarget assignments)	1	purified	No	FTT1532	56708566		hypothetical protein FTT1532 [Francisell...	162	Drug Target	Phase 3: June 2008	3NWZ	16%	Francisella tularensis	Unknown function	General

IDP01612 (show subtarget assignments)	1	cloned	No	FTT1538c	56708570		hypothetical protein FTT1538c [Francisel...	327	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP02112
(show subtarget assignments)

1

cloned

No

FTT1024c

56708113

yhbG

ABC transporter, ATP-binding protein [Fr...

243

Conserved; Drug target functions

Phase 3: June 2008

1JI0

34.6%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02286
(show subtarget assignments)

1

cloned

No

FTT1029

56708118

dacD

D-alanyl-D-alanine carboxypeptidase (pen...

444

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3IT9

31.1%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01857
(show subtarget assignments)

1

soluble

No

FTT1034c

56708121

ndh

NADH dehydrogenase [Francisella tularens...

420

Drug Target

Phase 3: June 2008

1XHC

21%

Francisella tularensis

Energy metabolism

Electron transport

IDP02083
(show subtarget assignments)

1

cloned

No

FTT1044c

56708131

ispB

octaprenyl-diphosphate synthase [Francis...

325

Drug Target

Phase 3: June 2008

3OYR

43.1%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02232
(show subtarget assignments)

1

expressed

No

FTT1050c

56708136

cysN

sulfate adenylate transferase subunit 1 ...

470

Drug Target

Phase 3: June 2008

1ZUN

56%

Francisella tularensis

Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo

Serine familySulfur metabolism,Purine ribonucleotide biosynthesis

IDP02227
(show subtarget assignments)

1

cloned

No

FTT1063

56708148

hemF

coproporphyrinogen III oxidase [Francise...

308

Drug Target

Phase 3: June 2008

1VJU

51.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04646
(show subtarget assignments)

1

soluble

No

FTT1085

56708168

hypothetical protein FTT_1085 [Francisel...

332

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1QXN

9.3%

Francisella tularensis

IDP02095
(show subtarget assignments)

1

in_pdb
3TNO
3TK7
3TE9
3TKF
3UPB
4E0C
3IGX

No

FTT1093c

56708176

talA

transaldolase B [Francisella tularensis ...

321

Conserved; Drug target functions

Phase 3: June 2008

3IGX

100%

Francisella tularensis

Energy metabolism

Pentose phosphate pathway

IDP02234
(show subtarget assignments)

1

cloned

No

FTT1094c

56708177

cytosol aminopeptidase family protein [F...

471

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3IJ3

41.1%

Francisella tularensis

N/A

IDP90003
(show subtarget assignments)

8

crystallized

No

FTT1103

56708183

conserved hypothetical lipoprotein

365

(Community Request)

Community Requests

3GYK

12.3%

Francisella tularensis

IDP02235
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1105c

56708184

msrA1

bifunctional methionine sulfoxide reduct...

284

Drug Target

Phase 3: June 2008

2GT3

23.2%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein modification and repair

IDP02236
(show subtarget assignments)

1

cloned

No

FTT1108

56708186

rRNA methyltransferase [Francisella tula...

250

Drug Target

Phase 3: June 2008

1IPA

29.3%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02351
(show subtarget assignments)

1

cloned

No

FTT1112c

56708190

rpoH

RNA polymerase factor sigma-32 [Francise...

292

Drug Target

Phase 3: June 2008

1IW7

25%

Francisella tularensis

Cellular processesTranscription

Adaptations to atypical conditionsTranscription factors

IDP02127
(show subtarget assignments)

1

cloned

No

FTT1116c

56708194

yajC

preprotein translocase family protein [F...

118

Conserved; Drug target functions

Phase 3: June 2008

2RDD

17.8%

Francisella tularensis

Protein fate

Protein and peptide secretion and trafficking

IDP02699
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1120c

56708198

tgt

queuine tRNA-ribosyltransferase. [Franci...

367

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1OZM

56.1%

Francisella tularensis

Protein synthesis

tRNA and rRNA base modification

IDP04647
(show subtarget assignments)

1

purified

No

FTT1127

56604696

Rhodanese-like family protein [Francisel...

252

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1YT8

18.3%

Francisella tularensis

IDP00331
(show subtarget assignments)

1

in_pdb
3RE3

Yes

FTT1128

56708205

ispF

2C-methyl-D-erythritol 2,4-cyclodiphosph...

159

Drug Target Function

Phase 2: March 2008

3RE3

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02241
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1129c

56708206

hypothetical protein FTT1129c [Francisel...

561

Drug Target

Phase 3: June 2008

1O5Z

11.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism

OtherNitrogen metabolism

IDP02255
(show subtarget assignments)

1

cloned

No

FTT1130c

56708207

cphA

cyanophycin synthetase [Francisella tula...

940

Drug Target

Phase 3: June 2008

2WTZ

13.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism

OtherNitrogen metabolism

IDP02044
(show subtarget assignments)

1

expressed

No

FTT1132c

56708208

glpQ

glycerophosphoryl diester phosphodiester...

250

Drug Target

Phase 3: June 2008

1O1Z

28%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02268
(show subtarget assignments)

1

expressed

No

FTT1133

56708209

pilB

Type IV pili nucleotide binding protein,...

592

Conserved; Drug target functions

Phase 3: June 2008

1P9R

31.1%

Francisella tularensis

Cell envelope

Surface structures

IDP02144
(show subtarget assignments)

1

cloned

No

FTT1136c

56708211

hypothetical protein FTT1136c [Francisel...

111

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP02423
(show subtarget assignments)

1

cloned

No

FTT1138

56708213

hemH

ferrochelatase [Francisella tularensis s...

333

Drug Target

Phase 3: June 2008

1HRK

27.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02424
(show subtarget assignments)

1

cloned

No

FTT1147c

56708218

dfp

4'-phosphopantothenoylcysteine decarboxy...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

19.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02430
(show subtarget assignments)

1

expressed

No

FTT1151c

56708222

hypothetical protein FTT1151c [Francisel...

95

Drug Target

Phase 3: June 2008

2JR5

25.3%

Francisella tularensis

Unknown function

General

IDP92249
(show subtarget assignments)

8

selected

No

FTT_1152

56604715

hypothetical protein [Francisella tulare...

127

virulence/pathogenesis / We recently described FTN_1133/FTL_0803/FTT_1152 as an important virulence facto...

Community Requests

Francisella tularensis

IDP02414
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1154c

56708225

aroB

3-dehydroquinate synthase [Francisella t...

359

Conserved; Drug target functions

Phase 3: June 2008

3OKF

44.3%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP02271
(show subtarget assignments)

1

crystallized

No

FTT1155c

56708226

aroK

shikimate kinase I [Francisella tularens...

176

Conserved; Drug target functions

Phase 3: June 2008

1KAG

58%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP02275
(show subtarget assignments)

1

cloned

No

FTT1158c

56708229

Type IV pili glycosylation protein [Fran...

198

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

Francisella tularensis

Cell envelopeCellular processes

Surface structuresPathogenesis,Cell adhesion

IDP02287
(show subtarget assignments)

1

purified

No

FTT1161

56708232

adk

adenylate kinase [Francisella tularensis...

218

Drug Target

Phase 3: June 2008

1AKE

56.4%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP02279
(show subtarget assignments)

1

crystallized

No

FTT1164c

56708234

era

GTP-binding protein Era [Francisella tul...

297

Drug Target

Phase 3: June 2008

1EGA

48.5%

Francisella tularensis

Cellular processesRegulatory functions

Cell divisionRNA interactions

IDP00336
(show subtarget assignments)

1

cloned

No

FTT1186

56708252

smpB

SsrA-binding protein

157

Drug Target Function

Phase 2: March 2008

1P6V

48.4%

Francisella tularensis

Protein synthesis

Other

IDP00335
(show subtarget assignments)

1

in_pdb
3OUT

No

FTT1197c

56708260

murI

glutamate racemase

265

Drug Target Function

Phase 2: March 2008

3OUT

100%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02119
(show subtarget assignments)

1

in_pdb
3KWM

No

FTT1208

56708271

rpiA

ribose-5-phosphate isomerase A [Francise...

224

Conserved; Drug target functions

Phase 3: June 2008

3KWM

100%

Francisella tularensis

Energy metabolism

Pentose phosphate pathway

IDP02295
(show subtarget assignments)

1

cloned

No

FTT1212c

56708274

gloA

lactoylglutathione lyase [Francisella tu...

127

Drug Target

Phase 3: June 2008

1F9Z

56.7%

Francisella tularensis

Energy metabolism

Other

IDP02345
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1220

56708282

5-formyltetrahydroformate cycloligase fa...

182

Drug Target

Phase 3: June 2008

2JCB

28.6%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02126
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1221

56708283

hypothetical protein FTT1221 [Francisell...

88

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelopeRegulatory functions,Unknown function

Biosynthesis and degradation of murein sacculus and peptidoglycanOther,General

IDP02437
(show subtarget assignments)

1

expressed

No

FTT1226c

56708288

iscS

cysteine desulfarase [Francisella tulare...

391

Drug Target

Phase 3: June 2008

1P3W

41.9%

Francisella tularensis

Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers

Pyruvate familyOther

IDP02714
(show subtarget assignments)

1

purified

No

FTT1231

56708293

mesJ

PP-loop family protein [Francisella tula...

398

Conserved; Drug target functions

Phase 3: June 2008

1NI5

27.3%

Francisella tularensis

Cellular processes

Cell division

IDP02297
(show subtarget assignments)

1

cloned

No

FTT1235c

56708297

lpcC

glycosyl transferase group 1 family prot...

354

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2GEJ

17.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02228
(show subtarget assignments)

1

cloned

No

FTT1240c

56708302

hypothetical protein FTT1240c [Francisel...

182

Drug Target

Phase 3: June 2008

2P0T

32.4%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02434
(show subtarget assignments)

1

soluble

No

FTT1241

56708303

glyA

serine hydroxymethyltransferase [Francis...

417

Drug Target

Phase 3: June 2008

3GBX

67.1%

Francisella tularensis

Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin

Serine familyFolic acid,Purine ribonucleotide biosynthesis

IDP04648
(show subtarget assignments)

1

selected

No

FTT1245

56708307

rluD

ribosomal large subunit pseudouridine sy...

332

drug target; conserved gene;

Phase 4: April 2009

1V9F

43.1%

Francisella tularensis

Protein synthesis

tRNA and rRNA base modification

IDP02457
(show subtarget assignments)

1

expressed

No

FTT1248

56708310

ABC transporter, ATP-binding protein [Fr...

253

Drug Target

Phase 3: June 2008

1B0U

31.1%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02301
(show subtarget assignments)

1

cloned

No

FTT1249

56708311

cell entry (mce) related family protein ...

241

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02379
(show subtarget assignments)

1

expressed

No

FTT1257

56708319

emrA1

HlyD family secretion protein [Francisel...

340

Conserved; Drug target functions

Phase 3: June 2008

4DK0

22.1%

Francisella tularensis

Cellular processesTransport and binding proteins

Toxin production and resistanceOther

IDP02416
(show subtarget assignments)

1

purified

No

FTT1259

56708321

nadE

NH(3)-dependent NAD(+) synthetase [Franc...

249

Conserved; Drug target functions

Phase 3: June 2008

3FIU

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP02393
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1269c

56708329

dnaK

heat shock protein DnaK [Francisella tul...

642

Conserved; Drug target functions

Phase 3: June 2008

2KHO

71.3%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP02360
(show subtarget assignments)

1

soluble

No

FTT1270c

56708330

grpE

heat shock protein GrpE [Francisella tul...

195

Conserved; Drug target functions

Phase 3: June 2008

1DKG

36.9%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP91216
(show subtarget assignments)

1

crystallized

No

FTT_1275

56708335

mglA

macrophage growth locus, subunit A [Fran...

205

potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3MDK

25.4%

Francisella tularensis

IDP04649
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1283

56708343

trmE

tRNA modification GTPase TrmE [Francisel...

450

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XZP

36.1%

Francisella tularensis

Protein synthesis

tRNA and rRNA base modification

IDP02497
(show subtarget assignments)

1

cloned

No

FTT1287

56708346

cbs

cystathionine beta-synthase (cystein syn...

307

Conserved; Drug target functions

Phase 3: June 2008

4AEC

33.2%

Francisella tularensis

Amino acid biosynthesis

Serine family

IDP02356
(show subtarget assignments)

1

cloned

No

FTT1296

56708355

ubiE

menaquinone biosynthesis methyltransfera...

250

Conserved; Drug target functions

Phase 3: June 2008

2AVN

20%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02507
(show subtarget assignments)

1

cloned

No

FTT1298

56708357

ubiB

2-polyprenylphenol 6-hydroxylase [Franci...

552

Conserved; Drug target functions

Phase 3: June 2008

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04650
(show subtarget assignments)

1

expressed

No

FTT1302

56708360

hypothetical protein FTT_1302 [Francisel...

276

drug target; conserved gene;

Phase 4: April 2009

3GBP

88.3%

Francisella tularensis

IDP02387
(show subtarget assignments)

1

expressed

No

FTT1304c

56708362

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

282

Conserved; Drug target functions

Phase 3: June 2008

3TX1

33.7%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00341
(show subtarget assignments)

1

cloned

No

FTT1305c

56708363

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

444

Drug Target Function

Phase 2: March 2008

3SG1

32.7%

Francisella tularensis

IDP02738
(show subtarget assignments)

1

cloned

No

FTT1310c

56708367

hflB

ATP-dependent metalloprotease [Francisel...

638

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2DHR

39.3%

Francisella tularensis

N/A

IDP02341
(show subtarget assignments)

1

cloned

No

FTT1313c

56708370

greA

transcriptional elongation factor [Franc...

160

Conserved; Drug target functions

Phase 3: June 2008

1GRJ

63.1%

Francisella tularensis

Regulatory functions

Other

IDP02733
(show subtarget assignments)

1

in_pdb
3M5P
3Q7I
3Q88
3LJK

Yes

FTT1315c

56708372

pgi

glucose-6-phosphate isomerase [Francisel...

540

Conserved; Drug target functions

Phase 3: June 2008

3LJK

99.8%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02398
(show subtarget assignments)

1

in_pdb
3PEI

Yes

FTT1318c

56708375

pepA

cytosol aminopeptidase [Francisella tula...

479

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3PEI

100%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02739
(show subtarget assignments)

1

purified

No

FTT1321

56708378

peptidase M16 family protein [Francisell...

417

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3AMI

31.2%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02701
(show subtarget assignments)

1

soluble

No

FTT1322

56708379

peptidase M16 family protein [Francisell...

407

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3GWB

29%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02397
(show subtarget assignments)

1

purified

No

FTT1326

56708383

udp

uridine phosphorylase [Francisella tular...

267

Drug Target

Phase 3: June 2008

3O6V

43.1%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02352
(show subtarget assignments)

1

cloned

No

FTT1334c

56708390

hypothetical protein FTT1334c [Francisel...

169

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP90000
(show subtarget assignments)

8

cloned

No

FTT1352

56708408

hypothetical protein FTT1352

383

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Francisella tularensis

IDP02755
(show subtarget assignments)

1

expressed

No

FTT1365c

56708418

fbaB

fructose-1,6-bisphosphate aldolase [Fran...

354

Conserved; Drug target functions

Phase 3: June 2008

3GAK

46.6%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02363
(show subtarget assignments)

1

purified

No

FTT1366c

56708419

pyk

pyruvate kinase [Francisella tularensis ...

478

Conserved; Drug target functions

Phase 3: June 2008

1E0U

39.5%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02760
(show subtarget assignments)

1

in_pdb
4EHJ

No

FTT1367c

56708420

pgk

phosphogylcerate kinase [Francisella tul...

392

Conserved; Drug target functions

Phase 3: June 2008

4EHJ

100%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02310
(show subtarget assignments)

1

in_pdb
3KOM

No

FTT1369c

56708422

tktA

transketolase [Francisella tularensis su...

663

Conserved; Drug target functions

Phase 3: June 2008

3KOM

99.7%

Francisella tularensis

Energy metabolism

Pentose phosphate pathway

IDP00334
(show subtarget assignments)

1

in_pdb
3LYL

No

FTT1375

56708428

fabG

3-oxoacyl-(acyl-carrier-protein) reducta...

247

Drug Target Function

Phase 2: March 2008

3LYL

100%

Francisella tularensis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02595
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1384c

56708433

acetyltransferase [Francisella tularensi...

163

Drug Target

Phase 3: June 2008

Francisella tularensis

Central intermediary metabolismUnknown function

OtherEnzymes of unknown specificity

IDP02773
(show subtarget assignments)

1

crystallized

No

FTT1389

56708438

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

264

Conserved; Drug target functions

Phase 3: June 2008

1O66

41.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02771
(show subtarget assignments)

1

in_pdb
3N8H
3QTT

Yes

FTT1390

56708439

panC

pantoate-beta-alanine ligase [Francisell...

261

Conserved; Drug target functions

Phase 3: June 2008

3N8H

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02730
(show subtarget assignments)

1

in_pdb
3OUG

Yes

FTT1391

56708440

panD

aspartate alpha-decarboxylase [Francisel...

111

Drug Target

Phase 3: June 2008

3OUG

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02308
(show subtarget assignments)

1

expressed

No

FTT1400c

56708448

hypothetical protein FTT1400c [Francisel...

128

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02779
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1405c

56708453

gloB

hydroxyacylglutathione hydrolase [Franci...

252

Conserved; Drug target functions

Phase 3: June 2008

2QED

34.1%

Francisella tularensis

Energy metabolism

Other

IDP02585
(show subtarget assignments)

1

purified

No

FTT1416c

56708463

lipoprotein [Francisella tularensis subs...

137

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP04651
(show subtarget assignments)

1

cloned

No

FTT1417

56708464

carbon-nitrogen hydrolase [Francisella t...

261

drug target; conserved gene;

Phase 4: April 2009

2E11

34.3%

Francisella tularensis

IDP04652
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1432c

56708477

ppnK

inorganic phosphate/ATP-NAD kinase [Fran...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2AN1

41.6%

Francisella tularensis

IDP02293
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1445

56708487

trxA1

thioredoxin [Francisella tularensis subs...

107

Conserved; Drug target functions

Phase 3: June 2008

2H71

50.5%

Francisella tularensis

Energy metabolism

Electron transport

IDP02419
(show subtarget assignments)

1

purified

No

FTT1447c

56708489

manB

phosphomannomutase [Francisella tularens...

494

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2F7L

25.7%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02792
(show subtarget assignments)

1

cloned

No

FTT1461c

56708502

wbtD

galacturonosyl transferase [Francisella ...

363

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2GEJ

18.5%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02162
(show subtarget assignments)

1

cloned

No

FTT1463c

56708504

wbtB

galactosyl transferase [Francisella tula...

205

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02462
(show subtarget assignments)

1

expressed

No

FTT1467c

56708507

nadB

L-aspartate oxidase [Francisella tularen...

495

Conserved; Drug target functions

Phase 3: June 2008

1CHU

38.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP91059
(show subtarget assignments)

8

soluble

No

FTT_1472c

56708512

ppiC

peptidyl-prolyl cis-trans isomerase [Fra...

92

virulence/pathogenesis / Gene encodes a SurA orthologue which has shown to be important for virulence in ...

Community Requests

1JNS

47.8%

Francisella tularensis

IDP02450
(show subtarget assignments)

1

expressed

No

FTT1475

56708515

galT

galactose-1-phosphate uridylyltransferas...

341

Drug Target

Phase 3: June 2008

1HXQ

51.6%

Francisella tularensis

Energy metabolism

Sugars

IDP02441
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1478c

56708518

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

250

Drug Target

Phase 3: June 2008

3TQD

51.2%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02812
(show subtarget assignments)

1

cloned

No

FTT1484c

56708523

aceF

dihydrolipoamide acetyltransferase [Fran...

631

Conserved; Drug target functions

Phase 3: June 2008

3DUF

26%

Francisella tularensis

Energy metabolism

Pyruvate dehydrogenase

IDP00333
(show subtarget assignments)

1

crystallized

No

FTT1487

56708526

coaE

Dephospho-CoA kinase

204

Drug Target Function

Phase 2: March 2008

1JJV

31.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04653
(show subtarget assignments)

1

expressed

No

FTT1503

56708541

xerC

integrase/recombinase XerC [Francisella ...

292

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A0P

34.6%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP02827
(show subtarget assignments)

1

cloned

No

FTT1508c

56708546

relA

GTP pyrophosphokinase [Francisella tular...

647

Drug Target

Phase 3: June 2008

1VJ7

20.1%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP01609
(show subtarget assignments)

1

crystallized

No

FTT1512c

56708550

dnaJ1

heat shock protein, hsp40 [Francisella t...

308

Conserved; Drug target functions

Phase 3: June 2008

3LZ8

34.2%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP02832
(show subtarget assignments)

1

expressed

No

FTT1518

56708554

ogt

methylated-DNA--protein-cysteine methylt...

190

Conserved; Drug target functions

Phase 3: June 2008

1SFE

28.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy

Heme, porphyrin, and cobalaminOther,tRNA and rRNA base modification

IDP02790
(show subtarget assignments)

1

cloned

No

FTT1525c

56708559

hypothetical protein FTT1525c [Francisel...

295

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04654
(show subtarget assignments)

1

purified

No

FTT1526c

56708560

idh

isocitrate dehydrogenase [Francisella tu...

747

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1ITW

62.7%

Francisella tularensis

IDP04044
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1530

56708564

fadB/acbP

fusion product of 3-hydroxacyl-CoA dehyd...

898

drug target; conserved gene;

Phase 4: April 2009

3K6J

11.7%

Francisella tularensis

Fatty acid and phospholipid metabolism

Degradation

IDP04655
(show subtarget assignments)

1

soluble

No

FTT1531

56708565

fadA

acetyl-CoA acetyltransferase [Francisell...

395

drug target; conserved gene;

Phase 4: April 2009

1ULQ

45.7%

Francisella tularensis

Fatty acid and phospholipid metabolism

Other

IDP02262
(show subtarget assignments)

1

purified

No

FTT1532

56708566

hypothetical protein FTT1532 [Francisell...

162

Drug Target

Phase 3: June 2008

3NWZ

16%

Francisella tularensis

Unknown function

General

IDP01612
(show subtarget assignments)

1

cloned

No

FTT1538c

56708570

hypothetical protein FTT1538c [Francisel...

327

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

Targets