Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01088 (show subtarget assignments)	1	expressed	No	STM4512	16767756	iadA	isoaspartyl dipeptidase	390	Drug Target Function	Phase 2: March 2008	1ONX	81%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01087 (show subtarget assignments)	1	cloned	No	STM4465	16767710		ornithine carbamoyltransferase	334	Conserved Gene / Pathway	Phase 2: March 2008	3UPD	75.7%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP00572 (show subtarget assignments)	1	cloned	No	YPO2717	16122921	lepB	lsignal peptidase I	332	Drug Target Function	Phase 2: March 2008	1T7D	54.8%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP01086 (show subtarget assignments)	1	in_crystallization_trials	No	STM4404	16767650	cysQ	PAPS (adenosine 3'-phosphate 5'-phosphos...	246	Conserved Gene / Pathway	Phase 2: March 2008	3B8B	48.1%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP01085 (show subtarget assignments)	1	in_crystallization_trials	No	STM4397	161353572	fklB	FKBP-type 22KD peptidyl-prolyl cis-trans...	206	Conserved Gene / Pathway	Phase 2: March 2008	1FD9	40.3%	Salmonella enterica	Protein synthesis	Translation factors

IDP00570 (show subtarget assignments)	1	expressed	No	YPO2042	16122281		putative oxidoreductase	536	Conserved Gene / Pathway	Phase 2: March 2008	1TLT	34.9%	Yersinia pestis	Cellular processes	Pathogenesis

IDP01084 (show subtarget assignments)	1	purified	No	STM4377	161353573	aidB	putative acyl-CoA dehydrogenase	546	Conserved Gene / Pathway	Phase 2: March 2008	3DJL	84.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP01083 (show subtarget assignments)	1	in_pdb 3OPK	No	STM4324	16767573	cutA	divalent-cation tolerance protein CutA	115	Conserved Gene / Pathway	Phase 2: March 2008	3OPK	100%	Salmonella enterica	Cellular processes	Detoxification

IDP00571 (show subtarget assignments)	1	in_pdb 3GOS	No	YPO1041	16121341	dapD	2,3,4,5-tetrahydropyridine-2-carboxylate...	274	Virulence Associated Factor	Phase 2: March 2008	3GOS	100%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01082 (show subtarget assignments)	1	expressed	No	STM4279	16767529	nrfC	putative formate-dependent nitrite reduc...	223	Essential Gene	Phase 2: March 2008	2VPW	35.9%	Salmonella enterica	Energy metabolism	Electron transport

IDP00569 (show subtarget assignments)	1	purified	No	YPO4016	16124139	hutH	histidine ammonia-lyase	510	Drug Target Function	Phase 2: March 2008	1GK2	77.5%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP01081 (show subtarget assignments)	1	soluble	No	STM4267	16767517		putative glutathione S-transferase	222	Conserved Gene / Pathway	Phase 2: March 2008	4ECI	28.4%	Salmonella enterica	Cellular processes	Detoxification

IDP01080 (show subtarget assignments)	0	work_stopped	No	STM4220	16767470	lysC	aspartate kinase III	449	Conserved Gene / Pathway	Phase 2: March 2008	2J0W	93.1%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP01079 (show subtarget assignments)	0	work_stopped	No	STM4167	16767421	hemE	uroporphyrinogen decarboxylase	354	Essential Gene	Phase 2: March 2008	3CYV	96%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00568 (show subtarget assignments)	0	work_stopped	No	YPO0106	16120453	hslV	ATP-dependent protease peptidase subunit...	174	Conserved Gene / Pathway	Phase 2: March 2008	1E94	90.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01078 (show subtarget assignments)	1	in_crystallization_trials	No	STM4137	16767396	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	342	Essential Gene	Phase 2: March 2008	1MBB	82.2%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01077 (show subtarget assignments)	0	work_stopped	No	STM4122	161353577	argB	acetylglutamate kinase	257	Conserved Gene / Pathway	Phase 2: March 2008	1GS5	94.2%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP00566 (show subtarget assignments)	1	purified	No	YPO0279	16120618	hmuV	hemin transport system ATP-binding prote...	266	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	30.5%	Yersinia pestis	Transport and binding proteins	Other

IDP01075 (show subtarget assignments)	1	cloned	No	STM4106	16767372	katG	hydroperoxidase	726	Essential Gene	Phase 2: March 2008	1MWV	64.3%	Salmonella enterica	Cellular processes	Detoxification

IDP00567 (show subtarget assignments)	0	work_stopped	No	YPO1113	16121413	kgd	alpha-ketoglutarate decarboxylase	935	Virulence Associated Factor	Phase 2: March 2008	2JGD	87.8%	Yersinia pestis	Energy metabolism	TCA cycle

IDP01074 (show subtarget assignments)	1	in_pdb 3FPK	Yes	STM4084	16767350	fpr	ferredoxin-NADP reductase	248	Conserved Gene / Pathway	Phase 2: March 2008	3FPK	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP00565 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0281	16120620	hmuT	hemin-binding periplasmic protein	279	Conserved Gene / Pathway	Phase 2: March 2008	3MD9	91%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP01073 (show subtarget assignments)	1	purified	No	STM4044	16767310		putative alcohol dehydrogenase	382	Conserved Gene / Pathway	Phase 2: March 2008	1RRM	42.6%	Salmonella enterica	Energy metabolism	Fermentation

IDP01072 (show subtarget assignments)	1	cloned	No	STM4003	16767268	yihI	hypothetical protein STM4003	171	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01071 (show subtarget assignments)	1	in_pdb 3GOA	Yes	STM3982	16767252	fadA	3-ketoacyl-CoA thiolase	387	Conserved Gene / Pathway	Phase 2: March 2008	3GOA	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP00564 (show subtarget assignments)	1	selected	No	YPO1403	16121683	mukF	condesin subunit F	440	Conserved Gene / Pathway	Phase 2: March 2008	3EUH	84.8%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP01070 (show subtarget assignments)	1	expressed	No	STM3949	16767219	xerC	site-specific tyrosine recombinase XerC ...	300	Drug Target Function	Phase 2: March 2008	1A0P	37.3%	Salmonella enterica	Cellular processes	Cell division

IDP01069 (show subtarget assignments)	1	soluble	No	STM3938	16767209	hemC	porphobilinogen deaminase	318	Conserved Gene / Pathway	Phase 2: March 2008	1AH5	87.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00562 (show subtarget assignments)	1	purified	No	YPO2908	16123099	hmp	nitric oxide dioxygenase	396	Virulence Associated Factor	Phase 2: March 2008	1GVH	63.1%	Yersinia pestis	Energy metabolism	Electron transport

IDP01068 (show subtarget assignments)	0	work_stopped	No	STM3920	16767195	wecB	UDP-N-acetyl glucosamine-2-epimerase	376	Drug Target Function	Phase 2: March 2008	1F6D	85.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01067 (show subtarget assignments)	1	expressed	No	STM3854	16767138	pstB	phosphate transporter subunit	257	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	36.2%	Salmonella enterica	Transport and binding proteins	Anions

IDP00563 (show subtarget assignments)	1	purified	No	YPO0283	16120622	hmuR	hemin receptor precursor	676	Conserved Gene / Pathway	Phase 2: March 2008	3FHH	66.3%	Yersinia pestis	Transport and binding proteins	Other

IDP01066 (show subtarget assignments)	1	expressed	No	STM3819	16767104	ccmA	heme exporter protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	32.7%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP00561 (show subtarget assignments)	0	work_stopped	No	YPO1046	16121346	pyrH	uridylate kinase	241	Conserved Gene / Pathway	Phase 2: March 2008	2BNE	90.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP01065 (show subtarget assignments)	1	expressed	No	STM3722	16767007	rfaG	glucosyltransferase I	374	Drug Target Function	Phase 2: March 2008	2IV7	86.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01064 (show subtarget assignments)	1	cloned	No	STM3719	16767004	rfaB	UDP-D-galactose:(glucosyl)lipopolysaccha...	359	Essential Gene	Phase 2: March 2008	2JJM	13.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01063 (show subtarget assignments)	1	soluble	No	STM3702	16766987	grxC	glutaredoxin 3	83	Conserved Gene / Pathway	Phase 2: March 2008	1FOV	86.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP00560 (show subtarget assignments)	1	soluble	No	YPO3852	16123987	hemY	putative protoheme IX biogenesis protein...	406	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Unknown function	General

IDP01062 (show subtarget assignments)	1	cloned	No	STM3626	16766913	dppF	dipeptide transporter ATP-binding subuni...	337	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	27.6%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP01061 (show subtarget assignments)	1	in_crystallization_trials	No	STM3591	16766877	uspA	universal stress protein A	144	Conserved Gene / Pathway	Phase 2: March 2008	1JMV	66.7%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP00559 (show subtarget assignments)	1	purified	No	YPO3032	16123209	hemF	coproporphyrinogen III oxidase	309	Conserved Gene / Pathway	Phase 2: March 2008	3E8J	59.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00558 (show subtarget assignments)	1	purified	No	YPO0654	16120979	rfaE	bifunctional heptose 7-phosphate kinase/...	476	Conserved Gene / Pathway	Phase 2: March 2008	2FV7	16.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01060 (show subtarget assignments)	1	crystallized	No	STM3561	16766847	livG	leucine/isoleucine/valine transporter AT...	255	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01059 (show subtarget assignments)	1	purified	No	STM3509	16766797	bioH	carboxylesterase BioH	256	Drug Target Function	Phase 2: March 2008	1M33	79.3%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01058 (show subtarget assignments)	1	in_crystallization_trials	No	STM3486	16766774	aroB	3-dehydroquinate synthase	362	Conserved Gene / Pathway	Phase 2: March 2008	3OKF	62.4%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP00557 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3382	16123531	gsrA	serine endoprotease	481	Virulence Associated Factor	Phase 2: March 2008	2ZLE	71.9%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP01057 (show subtarget assignments)	0	work_stopped	No	STM3445	16766734	tuf	elongation factor Tu	394	Conserved Gene / Pathway	Phase 2: March 2008	1D8T	99.5%	Salmonella enterica	Protein synthesis	Translation factors

IDP01056 (show subtarget assignments)	1	in_pdb 3R3R	Yes	STM3399	16766688	yrdA	putative ferripyochelin-binding protein ...	184	Conserved Gene / Pathway	Phase 2: March 2008	3R3R	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP01055 (show subtarget assignments)	1	crystallized	No	STM3371	16766666	maf	Maf-like protein	197	Conserved Gene / Pathway	Phase 2: March 2008	1EX2	43.7%	Salmonella enterica	Cellular processes	Cell division

IDP00556 (show subtarget assignments)	1	cloned	No	YPO2686	16122891	pgm	phosphoglucomutase	547	Drug Target Function	Phase 2: March 2008	2FUV	82.4%	Yersinia pestis	Energy metabolism	Sugars

IDP01054 (show subtarget assignments)	1	purified	No	STM3363	16766658	yhcO	putative cytoplasmic protein	90	Conserved Gene / Pathway	Phase 2: March 2008	2CX6	76.7%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01053 (show subtarget assignments)	1	cloned	No	STM3330	16766625	gltB	glutamate synthase subunit alpha	1486	Conserved Gene / Pathway	Phase 2: March 2008	1EA0	45.2%	Salmonella enterica	Central intermediary metabolism	Other

IDP00554 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1549	16121822	hisG	ATP phosphoribosyltransferase	299	Virulence Associated Factor	Phase 2: March 2008	1H3D	88%	Yersinia pestis	Amino acid biosynthesis	Histidine family

IDP01052 (show subtarget assignments)	1	expressed	No	STM3324	16766619	ptsO	phosphohistidinoprotein-hexose phosphotr...	90	Conserved Gene / Pathway	Phase 2: March 2008	1JEM	34.4%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01051 (show subtarget assignments)	1	expressed	No	STM3219	16766518	fadH	2,4-dieonyl-CoA reductase	672	Drug Target Function	Phase 2: March 2008	1PS9	85.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP00555 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3424	16123573	nadC	quinolinate phosphoribosyltransferase	302	Conserved Gene / Pathway	Phase 2: March 2008	1QAP	72.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP01050 (show subtarget assignments)	1	cloned	No	STM3201	16766501	glnE	bifunctional glutamine-synthetase adenyl...	947	Conserved Gene / Pathway	Phase 2: March 2008	3K7D	47.3%	Salmonella enterica	Protein synthesis	Translation factors

IDP00553 (show subtarget assignments)	1	expressed	No	YPO3939	16124067	glgA	glycogen synthase	476	Drug Target Function	Phase 2: March 2008	2QZS	71.4%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01049 (show subtarget assignments)	1	in_crystallization_trials	No	STM3183	16766483	icc	cyclic 3',5'-adenosine monophosphate pho...	275	Conserved Gene / Pathway	Phase 2: March 2008	2HY1	25.1%	Salmonella enterica	Central intermediary metabolism	Other

IDP01048 (show subtarget assignments)	1	in_pdb 3R3S	Yes	STM3157	16766457	yghA	oxidoreductase	294	Conserved Gene / Pathway	Phase 2: March 2008	3R3S	100%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP01047 (show subtarget assignments)	1	cloned	No	STM3152	16766452		putative methyl-accepting chemotaxis pro...	547	Conserved Gene / Pathway	Phase 2: March 2008	3ZX6	34.7%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP00552 (show subtarget assignments)	1	soluble	No	YPO0282	16120621	hmuS	hemin transport protein	345	Conserved Gene / Pathway	Phase 2: March 2008	2J0R	89.6%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP01046 (show subtarget assignments)	1	expressed	No	STM3138	16766438		putative methyl-accepting chemotaxis pro...	352	Conserved Gene / Pathway	Phase 2: March 2008	1QU7	16.8%	Salmonella enterica	Cellular processes	Other

IDP01045 (show subtarget assignments)	1	soluble	No	STM3114	16766415	speC	ornithine decarboxylase isozyme	711	Conserved Gene / Pathway	Phase 2: March 2008	1ORD	53.8%	Salmonella enterica	Central intermediary metabolism	Polyamine biosynthesis

IDP00551 (show subtarget assignments)	1	soluble	No	YPO0589	16120918	fadH	2,4-dienoyl-CoA reductase	673	Virulence Associated Factor	Phase 2: March 2008	1PS9	72.5%	Yersinia pestis	Fatty acid and phospholipid metabolism	Degradation

IDP00550 (show subtarget assignments)	1	purified	No	YPO3488	16123634	deaD	ATP-dependent RNA helicase DeaD	664	Virulence Associated Factor	Phase 2: March 2008	1HV8	23.3%	Yersinia pestis	Transcription	Other

IDP01044 (show subtarget assignments)	1	purified	No	STM3070	16766371	epd	D-erythrose 4-phosphate dehydrogenase	348	Conserved Gene / Pathway	Phase 2: March 2008	2X5J	91.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP01043 (show subtarget assignments)	1	soluble	No	STM2985	16766289	ygdK	putative FeS center assembly protein	147	Conserved Gene / Pathway	Phase 2: March 2008	1NI7	86.4%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01042 (show subtarget assignments)	1	in_crystallization_trials	No	STM2973	16766278	fucO	L-1,2-propanediol oxidoreductase	382	Conserved Gene / Pathway	Phase 2: March 2008	1RRM	91.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP00549 (show subtarget assignments)	1	purified	No	YPO3814	16123948	ftsY	cell division protein	541	Conserved Gene / Pathway	Phase 2: March 2008	2YHS	63.7%	Yersinia pestis	Cellular processes	Cell division

IDP01041 (show subtarget assignments)	1	purified	No	STM2971	16766276	sdaB	L-serine dehydratase/L-threonine deamina...	455	Conserved Gene / Pathway	Phase 2: March 2008	2IQQ	16%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP01040 (show subtarget assignments)	1	expressed	No	STM2935	16766241	cysD	sulfate adenylyltransferase subunit 2	302	Conserved Gene / Pathway	Phase 2: March 2008	1ZUN	75.2%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP01039 (show subtarget assignments)	1	expressed	No	STM2934	16766240	cysN	sulfate adenylyltransferase subunit 1	479	Conserved Gene / Pathway	Phase 2: March 2008	1ZUN	52.4%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP00548 (show subtarget assignments)	1	cloned	No	YPO0549	16120877	ftsI	penicillin-binding protein 3	587	Drug Target Function	Phase 2: March 2008	3OC2	41.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01038 (show subtarget assignments)	1	in_pdb 3GHZ	No	STM2929	16766235	ispF	2-C-methyl-D-erythritol 2,4-cyclodiphosp...	159	Drug Target Function	Phase 2: March 2008	3GHZ	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01037 (show subtarget assignments)	0	work_stopped	No	STM2927	16766233	surE	stationary phase survival protein SurE	253	potential drug target / Conserved Gene / Pathway	Phase 2: March 2008	2V4N	100%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP00546 (show subtarget assignments)	1	expressed	No	YPO0359	16120694	frdB	fumarate reductase iron-sulfur subunit	244	Virulence Associated Factor	Phase 2: March 2008	1KF6	84.8%	Yersinia pestis	Energy metabolism	Anaerobic

IDP01036 (show subtarget assignments)	1	in_crystallization_trials	No	STM2897	16766203	invE	invasion protein	372	Conserved Gene / Pathway	Phase 2: March 2008	2VJ5	26.1%	Salmonella enterica	Cellular processes	Pathogenesis

IDP01035 (show subtarget assignments)	0	work_stopped	No	STM4146	16767400	tuf	elongation factor Tu	394	Conserved Gene / Pathway	Phase 2: March 2008	1D8T	99.5%	Salmonella enterica	Protein synthesis	Translation factors

IDP00547 (show subtarget assignments)	1	expressed	No	YPO3813	16123947	ftsE	cell division protein FtsE	222	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	39.6%	Yersinia pestis	Cellular processes	Cell division

IDP01034 (show subtarget assignments)	0	work_stopped	No	STM4089	16767355	menG	ribonuclease activity regulator protein ...	161	Conserved Gene / Pathway	Phase 2: March 2008	1Q5X	97.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01033 (show subtarget assignments)	1	soluble	No	STM3815	16767100	ccmE	cytochrome c-type biogenesis protein Ccm...	159	Conserved Gene / Pathway	Phase 2: March 2008	1SR3	68.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01032 (show subtarget assignments)	1	soluble	No	STM3507	16766795	yhgG	putative cytoplasmic protein	78	Conserved Gene / Pathway	Phase 2: March 2008	1XN7	89.7%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01031 (show subtarget assignments)	0	work_stopped	No	STM3497	16766785	yrfH	ribosome-associated heat shock protein H...	133	Conserved Gene / Pathway	Phase 2: March 2008	1DM9	95.5%	Salmonella enterica	Protein synthesis	Other

IDP00545 (show subtarget assignments)	1	cloned	No	YPO2747	16122951	fadJ	multifunctional fatty acid oxidation com...	774	Conserved Gene / Pathway	Phase 2: March 2008	1WDK	34.1%	Yersinia pestis	Cellular processes	Detoxification

IDP01030 (show subtarget assignments)	1	cloned	No	STM2107	16765437	wcaH	GDP-mannose mannosyl hydrolase	167	Conserved Gene / Pathway	Phase 2: March 2008	2I8T	65.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01029 (show subtarget assignments)	0	work_stopped	No	STM1916	16765258	cheY	chemotaxis regulator transmitting signal...	129	Conserved Gene / Pathway	Phase 2: March 2008	2FKA	100%	Salmonella enterica	Cellular processes	Other

IDP00544 (show subtarget assignments)	1	purified	No	YPO2746	16122950	fadI	3-ketoacyl-CoA thiolase	436	Virulence Associated Factor	Phase 2: March 2008	1ULQ	37.4%	Yersinia pestis	Cellular processes	Detoxification

IDP00543 (show subtarget assignments)	1	purified	No	YPO4057	16124173	fdoH	formate dehydrogenase-O, iron-sulfur sub...	323	Conserved Gene / Pathway	Phase 2: March 2008	1KQF	70.9%	Yersinia pestis	Energy metabolism	Anaerobic

IDP01028 (show subtarget assignments)	1	in_crystallization_trials	No	STM1707	16765051	pyrF	orotidine 5'-phosphate decarboxylase	245	Essential Gene	Phase 2: March 2008	1EIX	88.2%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01027 (show subtarget assignments)	1	in_pdb	No	STM1346	16764697	ydiE	hypothetical protein STM1346	63	Conserved Gene / Pathway	Phase 2: March 2008	2LOJ	100%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00542 (show subtarget assignments)	1	cloned	No	YPO2744	16122948	fadL	long-chain fatty acid outer membrane tra...	423	Virulence Associated Factor	Phase 2: March 2008	1T16	64%	Yersinia pestis	Cell envelope	Other

IDP01026 (show subtarget assignments)	1	cloned	No	STM1267	16764618		putative cytoplasmic protein	82	Conserved Gene / Pathway	Phase 2: March 2008	2OXL	32.9%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00541 (show subtarget assignments)	1	purified	No	YPO1597	16121865	fabH	3-oxoacyl-(acyl carrier protein) synthas...	316	Conserved Gene / Pathway	Phase 2: March 2008	1HN9	81.1%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01025 (show subtarget assignments)	1	cloned	No	STM1196	16764551	acpP	acyl carrier protein	78	Conserved Gene / Pathway	Phase 2: March 2008	1L0H	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01024 (show subtarget assignments)	1	purified	No	STM1172	16764528	flgM	anti-sigma28 factor FlgM	97	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Cell envelope	Surface structures

IDP01023 (show subtarget assignments)	1	in_crystallization_trials	No	STM1051	16764411	sseI	secreted effector protein [Phage Gifsy-2...	322	Virulence Associated Factor	Phase 2: March 2008	3CXB	15.8%	Salmonella enterica	Unknown function	General

IDP00540 (show subtarget assignments)	1	purified	No	YPO2719	16122923	era	GTP-binding protein Era	303	Conserved Gene / Pathway	Phase 2: March 2008	1EGA	83.8%	Yersinia pestis	Cellular processes	Cell division

IDP01022 (show subtarget assignments)	1	in_crystallization_trials	No	STM0048	16763438	slpA	FKBP-type peptidyl-prolyl cis-trans isom...	149	Conserved Gene / Pathway	Phase 2: March 2008	3PR9	29.5%	Salmonella enterica	Protein synthesis	Translation factors

IDP01021 (show subtarget assignments)	1	cloned	No	STM0044	16763434	yaaY	putative cytoplasmic protein	71	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01088
(show subtarget assignments)

1

expressed

No

STM4512

16767756

iadA

isoaspartyl dipeptidase

390

Drug Target Function

Phase 2: March 2008

1ONX

81%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01087
(show subtarget assignments)

1

cloned

No

STM4465

16767710

ornithine carbamoyltransferase

334

Conserved Gene / Pathway

Phase 2: March 2008

3UPD

75.7%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP00572
(show subtarget assignments)

1

cloned

No

YPO2717

16122921

lepB

lsignal peptidase I

332

Drug Target Function

Phase 2: March 2008

1T7D

54.8%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP01086
(show subtarget assignments)

1

in_crystallization_trials

No

STM4404

16767650

cysQ

PAPS (adenosine 3'-phosphate 5'-phosphos...

246

Conserved Gene / Pathway

Phase 2: March 2008

3B8B

48.1%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP01085
(show subtarget assignments)

1

in_crystallization_trials

No

STM4397

161353572

fklB

FKBP-type 22KD peptidyl-prolyl cis-trans...

206

Conserved Gene / Pathway

Phase 2: March 2008

1FD9

40.3%

Salmonella enterica

Protein synthesis

Translation factors

IDP00570
(show subtarget assignments)

1

expressed

No

YPO2042

16122281

putative oxidoreductase

536

Conserved Gene / Pathway

Phase 2: March 2008

1TLT

34.9%

Yersinia pestis

Cellular processes

Pathogenesis

IDP01084
(show subtarget assignments)

1

purified

No

STM4377

161353573

aidB

putative acyl-CoA dehydrogenase

546

Conserved Gene / Pathway

Phase 2: March 2008

3DJL

84.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP01083
(show subtarget assignments)

1

in_pdb
3OPK

No

STM4324

16767573

cutA

divalent-cation tolerance protein CutA

115

Conserved Gene / Pathway

Phase 2: March 2008

3OPK

100%

Salmonella enterica

Cellular processes

Detoxification

IDP00571
(show subtarget assignments)

1

in_pdb
3GOS

No

YPO1041

16121341

dapD

2,3,4,5-tetrahydropyridine-2-carboxylate...

274

Virulence Associated Factor

Phase 2: March 2008

3GOS

100%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01082
(show subtarget assignments)

1

expressed

No

STM4279

16767529

nrfC

putative formate-dependent nitrite reduc...

223

Essential Gene

Phase 2: March 2008

2VPW

35.9%

Salmonella enterica

Energy metabolism

Electron transport

IDP00569
(show subtarget assignments)

1

purified

No

YPO4016

16124139

hutH

histidine ammonia-lyase

510

Drug Target Function

Phase 2: March 2008

1GK2

77.5%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP01081
(show subtarget assignments)

1

soluble

No

STM4267

16767517

putative glutathione S-transferase

222

Conserved Gene / Pathway

Phase 2: March 2008

4ECI

28.4%

Salmonella enterica

Cellular processes

Detoxification

IDP01080
(show subtarget assignments)

0

work_stopped

No

STM4220

16767470

lysC

aspartate kinase III

449

Conserved Gene / Pathway

Phase 2: March 2008

2J0W

93.1%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP01079
(show subtarget assignments)

0

work_stopped

No

STM4167

16767421

hemE

uroporphyrinogen decarboxylase

354

Essential Gene

Phase 2: March 2008

3CYV

96%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00568
(show subtarget assignments)

0

work_stopped

No

YPO0106

16120453

hslV

ATP-dependent protease peptidase subunit...

174

Conserved Gene / Pathway

Phase 2: March 2008

1E94

90.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01078
(show subtarget assignments)

1

in_crystallization_trials

No

STM4137

16767396

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

342

Essential Gene

Phase 2: March 2008

1MBB

82.2%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01077
(show subtarget assignments)

0

work_stopped

No

STM4122

161353577

argB

acetylglutamate kinase

257

Conserved Gene / Pathway

Phase 2: March 2008

1GS5

94.2%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP00566
(show subtarget assignments)

1

purified

No

YPO0279

16120618

hmuV

hemin transport system ATP-binding prote...

266

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

30.5%

Yersinia pestis

Transport and binding proteins

Other

IDP01075
(show subtarget assignments)

1

cloned

No

STM4106

16767372

katG

hydroperoxidase

726

Essential Gene

Phase 2: March 2008

1MWV

64.3%

Salmonella enterica

Cellular processes

Detoxification

IDP00567
(show subtarget assignments)

0

work_stopped

No

YPO1113

16121413

kgd

alpha-ketoglutarate decarboxylase

935

Virulence Associated Factor

Phase 2: March 2008

2JGD

87.8%

Yersinia pestis

Energy metabolism

TCA cycle

IDP01074
(show subtarget assignments)

1

in_pdb
3FPK

Yes

STM4084

16767350

fpr

ferredoxin-NADP reductase

248

Conserved Gene / Pathway

Phase 2: March 2008

3FPK

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP00565
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0281

16120620

hmuT

hemin-binding periplasmic protein

279

Conserved Gene / Pathway

Phase 2: March 2008

3MD9

91%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP01073
(show subtarget assignments)

1

purified

No

STM4044

16767310

putative alcohol dehydrogenase

382

Conserved Gene / Pathway

Phase 2: March 2008

1RRM

42.6%

Salmonella enterica

Energy metabolism

Fermentation

IDP01072
(show subtarget assignments)

1

cloned

No

STM4003

16767268

yihI

hypothetical protein STM4003

171

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01071
(show subtarget assignments)

1

in_pdb
3GOA

Yes

STM3982

16767252

fadA

3-ketoacyl-CoA thiolase

387

Conserved Gene / Pathway

Phase 2: March 2008

3GOA

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP00564
(show subtarget assignments)

1

selected

No

YPO1403

16121683

mukF

condesin subunit F

440

Conserved Gene / Pathway

Phase 2: March 2008

3EUH

84.8%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP01070
(show subtarget assignments)

1

expressed

No

STM3949

16767219

xerC

site-specific tyrosine recombinase XerC ...

300

Drug Target Function

Phase 2: March 2008

1A0P

37.3%

Salmonella enterica

Cellular processes

Cell division

IDP01069
(show subtarget assignments)

1

soluble

No

STM3938

16767209

hemC

porphobilinogen deaminase

318

Conserved Gene / Pathway

Phase 2: March 2008

1AH5

87.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00562
(show subtarget assignments)

1

purified

No

YPO2908

16123099

hmp

nitric oxide dioxygenase

396

Virulence Associated Factor

Phase 2: March 2008

1GVH

63.1%

Yersinia pestis

Energy metabolism

Electron transport

IDP01068
(show subtarget assignments)

0

work_stopped

No

STM3920

16767195

wecB

UDP-N-acetyl glucosamine-2-epimerase

376

Drug Target Function

Phase 2: March 2008

1F6D

85.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01067
(show subtarget assignments)

1

expressed

No

STM3854

16767138

pstB

phosphate transporter subunit

257

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

36.2%

Salmonella enterica

Transport and binding proteins

Anions

IDP00563
(show subtarget assignments)

1

purified

No

YPO0283

16120622

hmuR

hemin receptor precursor

676

Conserved Gene / Pathway

Phase 2: March 2008

3FHH

66.3%

Yersinia pestis

Transport and binding proteins

Other

IDP01066
(show subtarget assignments)

1

expressed

No

STM3819

16767104

ccmA

heme exporter protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

32.7%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP00561
(show subtarget assignments)

0

work_stopped

No

YPO1046

16121346

pyrH

uridylate kinase

241

Conserved Gene / Pathway

Phase 2: March 2008

2BNE

90.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP01065
(show subtarget assignments)

1

expressed

No

STM3722

16767007

rfaG

glucosyltransferase I

374

Drug Target Function

Phase 2: March 2008

2IV7

86.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01064
(show subtarget assignments)

1

cloned

No

STM3719

16767004

rfaB

UDP-D-galactose:(glucosyl)lipopolysaccha...

359

Essential Gene

Phase 2: March 2008

2JJM

13.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01063
(show subtarget assignments)

1

soluble

No

STM3702

16766987

grxC

glutaredoxin 3

83

Conserved Gene / Pathway

Phase 2: March 2008

1FOV

86.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP00560
(show subtarget assignments)

1

soluble

No

YPO3852

16123987

hemY

putative protoheme IX biogenesis protein...

406

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Unknown function

General

IDP01062
(show subtarget assignments)

1

cloned

No

STM3626

16766913

dppF

dipeptide transporter ATP-binding subuni...

337

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

27.6%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP01061
(show subtarget assignments)

1

in_crystallization_trials

No

STM3591

16766877

uspA

universal stress protein A

144

Conserved Gene / Pathway

Phase 2: March 2008

1JMV

66.7%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP00559
(show subtarget assignments)

1

purified

No

YPO3032

16123209

hemF

coproporphyrinogen III oxidase

309

Conserved Gene / Pathway

Phase 2: March 2008

3E8J

59.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00558
(show subtarget assignments)

1

purified

No

YPO0654

16120979

rfaE

bifunctional heptose 7-phosphate kinase/...

476

Conserved Gene / Pathway

Phase 2: March 2008

2FV7

16.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01060
(show subtarget assignments)

1

crystallized

No

STM3561

16766847

livG

leucine/isoleucine/valine transporter AT...

255

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01059
(show subtarget assignments)

1

purified

No

STM3509

16766797

bioH

carboxylesterase BioH

256

Drug Target Function

Phase 2: March 2008

1M33

79.3%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01058
(show subtarget assignments)

1

in_crystallization_trials

No

STM3486

16766774

aroB

3-dehydroquinate synthase

362

Conserved Gene / Pathway

Phase 2: March 2008

3OKF

62.4%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP00557
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3382

16123531

gsrA

serine endoprotease

481

Virulence Associated Factor

Phase 2: March 2008

2ZLE

71.9%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP01057
(show subtarget assignments)

0

work_stopped

No

STM3445

16766734

tuf

elongation factor Tu

394

Conserved Gene / Pathway

Phase 2: March 2008

1D8T

99.5%

Salmonella enterica

Protein synthesis

Translation factors

IDP01056
(show subtarget assignments)

1

in_pdb
3R3R

Yes

STM3399

16766688

yrdA

putative ferripyochelin-binding protein ...

184

Conserved Gene / Pathway

Phase 2: March 2008

3R3R

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP01055
(show subtarget assignments)

1

crystallized

No

STM3371

16766666

maf

Maf-like protein

197

Conserved Gene / Pathway

Phase 2: March 2008

1EX2

43.7%

Salmonella enterica

Cellular processes

Cell division

IDP00556
(show subtarget assignments)

1

cloned

No

YPO2686

16122891

pgm

phosphoglucomutase

547

Drug Target Function

Phase 2: March 2008

2FUV

82.4%

Yersinia pestis

Energy metabolism

Sugars

IDP01054
(show subtarget assignments)

1

purified

No

STM3363

16766658

yhcO

putative cytoplasmic protein

90

Conserved Gene / Pathway

Phase 2: March 2008

2CX6

76.7%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01053
(show subtarget assignments)

1

cloned

No

STM3330

16766625

gltB

glutamate synthase subunit alpha

1486

Conserved Gene / Pathway

Phase 2: March 2008

1EA0

45.2%

Salmonella enterica

Central intermediary metabolism

Other

IDP00554
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1549

16121822

hisG

ATP phosphoribosyltransferase

299

Virulence Associated Factor

Phase 2: March 2008

1H3D

88%

Yersinia pestis

Amino acid biosynthesis

Histidine family

IDP01052
(show subtarget assignments)

1

expressed

No

STM3324

16766619

ptsO

phosphohistidinoprotein-hexose phosphotr...

90

Conserved Gene / Pathway

Phase 2: March 2008

1JEM

34.4%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01051
(show subtarget assignments)

1

expressed

No

STM3219

16766518

fadH

2,4-dieonyl-CoA reductase

672

Drug Target Function

Phase 2: March 2008

1PS9

85.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP00555
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3424

16123573

nadC

quinolinate phosphoribosyltransferase

302

Conserved Gene / Pathway

Phase 2: March 2008

1QAP

72.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP01050
(show subtarget assignments)

1

cloned

No

STM3201

16766501

glnE

bifunctional glutamine-synthetase adenyl...

947

Conserved Gene / Pathway

Phase 2: March 2008

3K7D

47.3%

Salmonella enterica

Protein synthesis

Translation factors

IDP00553
(show subtarget assignments)

1

expressed

No

YPO3939

16124067

glgA

glycogen synthase

476

Drug Target Function

Phase 2: March 2008

2QZS

71.4%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01049
(show subtarget assignments)

1

in_crystallization_trials

No

STM3183

16766483

icc

cyclic 3',5'-adenosine monophosphate pho...

275

Conserved Gene / Pathway

Phase 2: March 2008

2HY1

25.1%

Salmonella enterica

Central intermediary metabolism

Other

IDP01048
(show subtarget assignments)

1

in_pdb
3R3S

Yes

STM3157

16766457

yghA

oxidoreductase

294

Conserved Gene / Pathway

Phase 2: March 2008

3R3S

100%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP01047
(show subtarget assignments)

1

cloned

No

STM3152

16766452

putative methyl-accepting chemotaxis pro...

547

Conserved Gene / Pathway

Phase 2: March 2008

3ZX6

34.7%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP00552
(show subtarget assignments)

1

soluble

No

YPO0282

16120621

hmuS

hemin transport protein

345

Conserved Gene / Pathway

Phase 2: March 2008

2J0R

89.6%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP01046
(show subtarget assignments)

1

expressed

No

STM3138

16766438

putative methyl-accepting chemotaxis pro...

352

Conserved Gene / Pathway

Phase 2: March 2008

1QU7

16.8%

Salmonella enterica

Cellular processes

Other

IDP01045
(show subtarget assignments)

1

soluble

No

STM3114

16766415

speC

ornithine decarboxylase isozyme

711

Conserved Gene / Pathway

Phase 2: March 2008

1ORD

53.8%

Salmonella enterica

Central intermediary metabolism

Polyamine biosynthesis

IDP00551
(show subtarget assignments)

1

soluble

No

YPO0589

16120918

fadH

2,4-dienoyl-CoA reductase

673

Virulence Associated Factor

Phase 2: March 2008

1PS9

72.5%

Yersinia pestis

Fatty acid and phospholipid metabolism

Degradation

IDP00550
(show subtarget assignments)

1

purified

No

YPO3488

16123634

deaD

ATP-dependent RNA helicase DeaD

664

Virulence Associated Factor

Phase 2: March 2008

1HV8

23.3%

Yersinia pestis

Transcription

Other

IDP01044
(show subtarget assignments)

1

purified

No

STM3070

16766371

epd

D-erythrose 4-phosphate dehydrogenase

348

Conserved Gene / Pathway

Phase 2: March 2008

2X5J

91.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP01043
(show subtarget assignments)

1

soluble

No

STM2985

16766289

ygdK

putative FeS center assembly protein

147

Conserved Gene / Pathway

Phase 2: March 2008

1NI7

86.4%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01042
(show subtarget assignments)

1

in_crystallization_trials

No

STM2973

16766278

fucO

L-1,2-propanediol oxidoreductase

382

Conserved Gene / Pathway

Phase 2: March 2008

1RRM

91.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP00549
(show subtarget assignments)

1

purified

No

YPO3814

16123948

ftsY

cell division protein

541

Conserved Gene / Pathway

Phase 2: March 2008

2YHS

63.7%

Yersinia pestis

Cellular processes

Cell division

IDP01041
(show subtarget assignments)

1

purified

No

STM2971

16766276

sdaB

L-serine dehydratase/L-threonine deamina...

455

Conserved Gene / Pathway

Phase 2: March 2008

2IQQ

16%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP01040
(show subtarget assignments)

1

expressed

No

STM2935

16766241

cysD

sulfate adenylyltransferase subunit 2

302

Conserved Gene / Pathway

Phase 2: March 2008

1ZUN

75.2%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP01039
(show subtarget assignments)

1

expressed

No

STM2934

16766240

cysN

sulfate adenylyltransferase subunit 1

479

Conserved Gene / Pathway

Phase 2: March 2008

1ZUN

52.4%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP00548
(show subtarget assignments)

1

cloned

No

YPO0549

16120877

ftsI

penicillin-binding protein 3

587

Drug Target Function

Phase 2: March 2008

3OC2

41.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01038
(show subtarget assignments)

1

in_pdb
3GHZ

No

STM2929

16766235

ispF

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

159

Drug Target Function

Phase 2: March 2008

3GHZ

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01037
(show subtarget assignments)

0

work_stopped

No

STM2927

16766233

surE

stationary phase survival protein SurE

253

potential drug target / Conserved Gene / Pathway

Phase 2: March 2008

2V4N

100%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP00546
(show subtarget assignments)

1

expressed

No

YPO0359

16120694

frdB

fumarate reductase iron-sulfur subunit

244

Virulence Associated Factor

Phase 2: March 2008

1KF6

84.8%

Yersinia pestis

Energy metabolism

Anaerobic

IDP01036
(show subtarget assignments)

1

in_crystallization_trials

No

STM2897

16766203

invE

invasion protein

372

Conserved Gene / Pathway

Phase 2: March 2008

2VJ5

26.1%

Salmonella enterica

Cellular processes

Pathogenesis

IDP01035
(show subtarget assignments)

0

work_stopped

No

STM4146

16767400

tuf

elongation factor Tu

394

Conserved Gene / Pathway

Phase 2: March 2008

1D8T

99.5%

Salmonella enterica

Protein synthesis

Translation factors

IDP00547
(show subtarget assignments)

1

expressed

No

YPO3813

16123947

ftsE

cell division protein FtsE

222

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

39.6%

Yersinia pestis

Cellular processes

Cell division

IDP01034
(show subtarget assignments)

0

work_stopped

No

STM4089

16767355

menG

ribonuclease activity regulator protein ...

161

Conserved Gene / Pathway

Phase 2: March 2008

1Q5X

97.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01033
(show subtarget assignments)

1

soluble

No

STM3815

16767100

ccmE

cytochrome c-type biogenesis protein Ccm...

159

Conserved Gene / Pathway

Phase 2: March 2008

1SR3

68.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01032
(show subtarget assignments)

1

soluble

No

STM3507

16766795

yhgG

putative cytoplasmic protein

78

Conserved Gene / Pathway

Phase 2: March 2008

1XN7

89.7%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01031
(show subtarget assignments)

0

work_stopped

No

STM3497

16766785

yrfH

ribosome-associated heat shock protein H...

133

Conserved Gene / Pathway

Phase 2: March 2008

1DM9

95.5%

Salmonella enterica

Protein synthesis

Other

IDP00545
(show subtarget assignments)

1

cloned

No

YPO2747

16122951

fadJ

multifunctional fatty acid oxidation com...

774

Conserved Gene / Pathway

Phase 2: March 2008

1WDK

34.1%

Yersinia pestis

Cellular processes

Detoxification

IDP01030
(show subtarget assignments)

1

cloned

No

STM2107

16765437

wcaH

GDP-mannose mannosyl hydrolase

167

Conserved Gene / Pathway

Phase 2: March 2008

2I8T

65.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01029
(show subtarget assignments)

0

work_stopped

No

STM1916

16765258

cheY

chemotaxis regulator transmitting signal...

129

Conserved Gene / Pathway

Phase 2: March 2008

2FKA

100%

Salmonella enterica

Cellular processes

Other

IDP00544
(show subtarget assignments)

1

purified

No

YPO2746

16122950

fadI

3-ketoacyl-CoA thiolase

436

Virulence Associated Factor

Phase 2: March 2008

1ULQ

37.4%

Yersinia pestis

Cellular processes

Detoxification

IDP00543
(show subtarget assignments)

1

purified

No

YPO4057

16124173

fdoH

formate dehydrogenase-O, iron-sulfur sub...

323

Conserved Gene / Pathway

Phase 2: March 2008

1KQF

70.9%

Yersinia pestis

Energy metabolism

Anaerobic

IDP01028
(show subtarget assignments)

1

in_crystallization_trials

No

STM1707

16765051

pyrF

orotidine 5'-phosphate decarboxylase

245

Essential Gene

Phase 2: March 2008

1EIX

88.2%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01027
(show subtarget assignments)

1

in_pdb

No

STM1346

16764697

ydiE

hypothetical protein STM1346

63

Conserved Gene / Pathway

Phase 2: March 2008

2LOJ

100%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00542
(show subtarget assignments)

1

cloned

No

YPO2744

16122948

fadL

long-chain fatty acid outer membrane tra...

423

Virulence Associated Factor

Phase 2: March 2008

1T16

64%

Yersinia pestis

Cell envelope

Other

IDP01026
(show subtarget assignments)

1

cloned

No

STM1267

16764618

putative cytoplasmic protein

82

Conserved Gene / Pathway

Phase 2: March 2008

2OXL

32.9%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00541
(show subtarget assignments)

1

purified

No

YPO1597

16121865

fabH

3-oxoacyl-(acyl carrier protein) synthas...

316

Conserved Gene / Pathway

Phase 2: March 2008

1HN9

81.1%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01025
(show subtarget assignments)

1

cloned

No

STM1196

16764551

acpP

acyl carrier protein

78

Conserved Gene / Pathway

Phase 2: March 2008

1L0H

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01024
(show subtarget assignments)

1

purified

No

STM1172

16764528

flgM

anti-sigma28 factor FlgM

97

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Cell envelope

Surface structures

IDP01023
(show subtarget assignments)

1

in_crystallization_trials

No

STM1051

16764411

sseI

secreted effector protein [Phage Gifsy-2...

322

Virulence Associated Factor

Phase 2: March 2008

3CXB

15.8%

Salmonella enterica

Unknown function

General

IDP00540
(show subtarget assignments)

1

purified

No

YPO2719

16122923

era

GTP-binding protein Era

303

Conserved Gene / Pathway

Phase 2: March 2008

1EGA

83.8%

Yersinia pestis

Cellular processes

Cell division

IDP01022
(show subtarget assignments)

1

in_crystallization_trials

No

STM0048

16763438

slpA

FKBP-type peptidyl-prolyl cis-trans isom...

149

Conserved Gene / Pathway

Phase 2: March 2008

3PR9

29.5%

Salmonella enterica

Protein synthesis

Translation factors

IDP01021
(show subtarget assignments)

1

cloned

No

STM0044

16763434

yaaY

putative cytoplasmic protein

71

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

Targets