Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91191 (show subtarget assignments)	1	in_pdb 4EJ7 3R78	No	CAJ77079	90265397	aphA1	Aminoglycoside phosphotransferase [Acine...	271	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3R78	100%	Acinetobacter baumannii

IDP91966 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100001092	298254195		ABC transporter substrate-binding protei...	271	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1GGG	28.4%	Streptococcus pneumoniae

IDP05446 (show subtarget assignments)	1	soluble	No	lmo1738	16803778	-	hypothetical protein lmo1738 [Listeria m...	271	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HV1	49.4%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP90656 (show subtarget assignments)	8	purified	No	Cj0384c	15791751	kdsA	2-dehydro-3-deoxyphosphooctonate aldolas...	271	Predicted Essential	Community Requests	1FWN	55.7%	Campylobacter jejuni

IDP02027 (show subtarget assignments)	1	soluble	No	CBU_0599	29541200	cysQ-1	3'(2'),5'-bisphosphate nucleotidase [Cox...	271	Conserved; Drug target functions	Phase 3: June 2008	3B8B	39.5%	Coxiella burnetii	Central intermediary metabolism	Sulfur metabolism

IDP05269 (show subtarget assignments)	1	soluble	No	lmo0517	16802560	-	hypothetical protein lmo0517 [Listeria m...	271	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3R7A	39.1%	Listeria monocytogenes	Energy metabolism: Glycolysis/gluconeogenesis

IDP04274 (show subtarget assignments)	1	cloned	No	YPCD1.49	16082737	virF	transcriptional regulator [Yersinia pest...	271	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	3OIO	11.8%	Yersinia pestis	Regulatory functions	Other

IDP01785 (show subtarget assignments)	1	expressed	No	CBU_0667	29541271	dapD	2,3,4,5-tetrahydropyridine-2,6-dicarboxy...	271	Conserved; Drug target functions	Phase 3: June 2008	1KGQ	62.7%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01763 (show subtarget assignments)	1	cloned	No	YPO3627	16123769	ssuB	aliphatic sulfonates transport ATP-bindi...	271	Conserved; CD; Drug target functions	Phase 3: June 2008	2IT1	35.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP04232 (show subtarget assignments)	1	cloned	No	CPF_0693	110799915	aroE	shikimate 5-dehydrogenase [Clostridium p...	271	conserved gene; putative drug target function;	Phase 4: April 2009	3FBT	46.9%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP91012 (show subtarget assignments)	8	expressed	No	y2259	22126145		hypothetical protein y2259 [Yersinia pes...	271	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests			Yersinia pestis

IDP05049 (show subtarget assignments)	1	soluble	No	BA_5058	30259547		putative lipoprotein [Bacillus anthracis...	271	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP04727 (show subtarget assignments)	1	purified	No	CPF_2072	110800396		hemolysin A [Clostridium perfringens ATC...	271	conserved gene; putative drug target function;	Phase 4: April 2009	3HP7	49.8%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP91800 (show subtarget assignments)	8	in_crystallization_trials	No	p6418_01	219372022	sul2	dihydropteroate synthase [Escherichia co...	271	drug resistance / Deactivates antibiotic sulfonamide by ligating on p-aminobenzoic acid; we will c...	Community Requests	2Y5J	38.1%	Escherichia coli

IDP00732 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2473	57286467		peptide ABC transporter, ATP-binding pro...	271	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	31.7%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP01370 (show subtarget assignments)	1	purified	No	VC0247	15640277		lipopolysaccharide/O-antigen transport p...	271	Conserved Gene / Pathway	Phase 2: March 2008	1OXS	25.8%	Vibrio cholerae	Transport and binding proteins	Other

IDP91718 (show subtarget assignments)	8	selected	No	NP_060140	109148508	OTUB1	ubiquitin thioesterase OTUB1 [Homo sapie...	271	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	4DDG	90.8%	Homo sapiens

IDP00615 (show subtarget assignments)	1	expressed	No	SACOL1160	57284445	sdhB	succinate dehydrogenase iron-sulfur subu...	271	Conserved Gene / Pathway	Phase 2: March 2008	1E7P	25.1%	Staphylococcus aureus	Energy metabolism	TCA cycle

IDP01150 (show subtarget assignments)	1	expressed	No	BA_4493	34582388		Phosphate import ATP-binding protein pst...	271	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	32.8%	Bacillus anthracis	Transport and binding proteins	Anions

IDP01128 (show subtarget assignments)	1	expressed	No	BA_4595	30259095		iron compound ABC transporter, ATP-bindi...	272	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	29.8%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP91167 (show subtarget assignments)	8	expressed	No	STM3401	16766690	aroE	shikimate 5-dehydrogenase	272	potential drug target / Shikimate pathway enzyme	Community Requests	1NYT	84.9%	Salmonella enterica

IDP04390 (show subtarget assignments)	1	cloned	No	CPF_0618	110799563	pstS	phosphate ABC transporter, phosphate-bin...	272	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	36.4%	Clostridium perfringens	Transport and binding proteins	Anions

IDP05091 (show subtarget assignments)	1	cloned	No	CD0256	126697828	motA	chemotaxis protein [Clostridium difficil...	272	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP90783 (show subtarget assignments)	8	cloned	No	YPO0649	16120974	uppP	undecaprenyl pyrophosphate phosphatase [...	272	Predicted Essential	Community Requests			Yersinia pestis

IDP90926 (show subtarget assignments)	8	purified	No	STM3859	16767143	aroE	shikimate 5-dehydrogenase [Salmonella ty...	272	Predicted Essential	Community Requests	1NPY	55.5%	Salmonella enterica

IDP01841 (show subtarget assignments)	1	purified	No	STM2549	16765869	asrB	anaerobic sulfite reductase subunit B [S...	272	Conserved; Drug target functions	Phase 3: June 2008	1KRH	18.8%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01780 (show subtarget assignments)	1	in_crystallization_trials	No	STM0784	16764148	ybhA	phosphotransferase [Salmonella typhimuri...	272	Conserved; Drug target functions	Phase 3: June 2008	2PQ0	30.5%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP05765 (show subtarget assignments)	1	soluble	No	lmo2812	16804849	-	hypothetical protein lmo2812 [Listeria m...	272	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IT9	32%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00174 (show subtarget assignments)	1	cloned	No	YPO1140	16121437	-	putative membrane protein	272	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Unknown function	General

IDP90631 (show subtarget assignments)	8	expressed	No	YPO2526	16122745		acyl-CoA thioester hydrolase YfbB [Yersi...	272	Predicted Essential	Community Requests	1R3D	42.3%	Yersinia pestis

IDP91186 (show subtarget assignments)	1	in_crystallization_trials	No	CAA37605	47078		unnamed protein product [Streptomyces gr...	272	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ND4	39.8%	Streptomyces griseus

IDP02433 (show subtarget assignments)	1	expressed	No	CBU_0010	29540636	aroE	shikimate 5-dehydrogenase [Coxiella burn...	272	Conserved; Drug target functions	Phase 3: June 2008	1NYT	46.3%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01127 (show subtarget assignments)	1	expressed	No	BA_0618	30254221		iron compound ABC transporter, ATP-bindi...	273	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	29.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP05506 (show subtarget assignments)	1	soluble	No	CD1232	126698828		putative lipoprotein [Clostridium diffic...	273	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1NA0	15.8%	Clostridium difficile	Unknown function: General

IDP00538 (show subtarget assignments)	1	in_pdb 3GVD	No	YPO0070	16120421	cysE	serine acetyltransferase	273	Drug Target Function	Phase 2: March 2008	3GVD	100%	Yersinia pestis	Amino acid biosynthesis	Serine family

IDP05547 (show subtarget assignments)	1	soluble	No	lmo0285	16802331	-	putative lipoprotein [Listeria monocytog...	273	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TQW	41%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP90934 (show subtarget assignments)	8	crystallized	No	YPO0480	16120810	dapB	dihydrodipicolinate reductase [Yersinia ...	273	Predicted Essential	Community Requests	1ARZ	79.5%	Yersinia pestis

IDP91168 (show subtarget assignments)	8	purified	No	lmo1490	16803530	-	similar to shikimate 5-dehydrogenase (Ar...	273	potential drug target / Shikimate pathway enzyme	Community Requests	3DON	45.6%	Listeria monocytogenes

IDP01738 (show subtarget assignments)	1	cloned	No	STM1484	16764829		putative protease [Salmonella typhimuriu...	273	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP05408 (show subtarget assignments)	1	soluble	No	BA_1977	30256632		putative polysaccharide deacetylase [Bac...	273	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	31.1%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01343 (show subtarget assignments)	1	cloned	No	VC2649	15642644	cysE	serine acetyltransferase	273	Drug Target Function	Phase 2: March 2008	1T3D	72.2%	Vibrio cholerae	Amino acid biosynthesis	Serine family

IDP01333 (show subtarget assignments)	1	purified	No	VC0726	15640745		phosphate ABC transporter, ATP-binding p...	273	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	33%	Vibrio cholerae	Transport and binding proteins	Anions

IDP92081 (show subtarget assignments)	8	selected	No	TGME49_106970	237845145		thymidylate kinase, putative [Toxoplasma...	273	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1E2D	35.2%	Toxoplasma gondii

IDP91731 (show subtarget assignments)	8	selected	No	NP_958854	41393583	EGFL7	epidermal growth factor-like protein 7 [...	273	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2W86	15.8%	Homo sapiens

IDP00571 (show subtarget assignments)	1	in_pdb 3GOS	No	YPO1041	16121341	dapD	2,3,4,5-tetrahydropyridine-2-carboxylate...	274	Virulence Associated Factor	Phase 2: March 2008	3GOS	100%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02179 (show subtarget assignments)	1	soluble	No	CBU_2090	29542640	proC	pyrroline-5-carboxylate reductase [Coxie...	274	Conserved; Drug target functions	Phase 3: June 2008	3TRI	100%	Coxiella burnetii	Amino acid biosynthesis	Glutamate family

IDP02121 (show subtarget assignments)	1	cloned	No	FTT0360	56707511		Short-chain dehydrogenase/reductase [Fra...	274	Drug Target	Phase 3: June 2008	1FDW	27.7%	Francisella tularensis	Central intermediary metabolism	Other

IDP02803 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1960	16803999	fhuC	hypothetical protein lmo1960 [Listeria m...	274	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1B0U	28.5%	Listeria monocytogenes	Transport and binding proteins	Cations and iron carrying compounds

IDP90765 (show subtarget assignments)	8	purified	No	Cj1536c	15792844	galU	UTP-glucose-1-phosphate uridylyltransfer...	274	Predicted Essential	Community Requests	3JUJ	60.6%	Campylobacter jejuni

IDP00477 (show subtarget assignments)	1	purified	No	YPO3845	16123980	dapF	diaminopimelate epimerase	274	Conserved Gene / Pathway	Phase 2: March 2008	1GQZ	75.9%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP05313 (show subtarget assignments)	1	soluble	No	BA_1061	30254794		putative lipoprotein [Bacillus anthracis...	274	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP01751 (show subtarget assignments)	0	work_stopped	No	Cj1312	15792635		flagellar protein [Campylobacter jejuni ...	274	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008	3HBM	99.6%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP90705 (show subtarget assignments)	8	soluble	No	Cj1400c	15792718	fabI	enoyl-(acyl carrier protein) reductase [...	274	Predicted Essential	Community Requests	2PD3	67.2%	Campylobacter jejuni

IDP04641 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0693c	56707813	mutM	formamidopyrimidine-DNA glycosylase [Fra...	274	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1K82	43.1%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP02521 (show subtarget assignments)	1	soluble	No	Cj1146c	15792471	waaV	lipooligosaccharide biosynthesis glycosy...	274	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3L7I	25.4%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05626 (show subtarget assignments)	1	soluble	No	CD1430	126699034		putative exported polysaccharide deacety...	274	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1NY1	37.2%	Clostridium difficile	Cellular processes: Sporulation and germination

IDP02492 (show subtarget assignments)	1	crystallized	No	FTT1559c	56708586	proC	pyrroline-5-carboxylate reductase [Franc...	274	Conserved; Drug target functions	Phase 3: June 2008	3TRI	37.6%	Francisella tularensis	Amino acid biosynthesis	Glutamate family

IDP00583 (show subtarget assignments)	1	expressed	No	YPO2752	16122956	mepA	penicillin-insensitive murein endopeptid...	275	Drug Target Function	Phase 2: March 2008	1TZP	67.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02706 (show subtarget assignments)	1	cloned	No	FTT0470	56707612	apaH	diadenosine tetraphosphatase [Francisell...	275	Drug Target	Phase 3: June 2008	2DFJ	37.8%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP01049 (show subtarget assignments)	1	in_crystallization_trials	No	STM3183	16766483	icc	cyclic 3',5'-adenosine monophosphate pho...	275	Conserved Gene / Pathway	Phase 2: March 2008	2HY1	25.1%	Salmonella enterica	Central intermediary metabolism	Other

IDP05264 (show subtarget assignments)	1	expressed	No	CD3257	126700876		putative polysaccharide deacetylase [Clo...	275	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1W17	25.5%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00960 (show subtarget assignments)	1	in_pdb 3HMQ	No	STM1310	16764661	nadE	NAD synthetase	275	Drug Target Function	Phase 2: March 2008	3HMQ	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP05683 (show subtarget assignments)	1	cloned	No	lmo1379	16803419	-	OxaA-like protein precursor [Listeria mo...	275	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Cell envelope: Other

IDP92246 (show subtarget assignments)	8	selected	No	EF_2296	2499116		RecName: Full=Vancomycin B-type resistan...	275	drug resistance / Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...	Community Requests			Enterococcus faecalis

IDP05724 (show subtarget assignments)	1	soluble	No	BA_3370	30257913		ribonuclease [Bacillus anthracis str. Am...	275	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Transcription: Degradation of RNA

IDP90843 (show subtarget assignments)	8	in_pdb 3Q4G	Yes	VCA0207	15600976	nadE	NAD synthetase [Vibrio cholerae O1 biova...	276	Predicted Essential	Community Requests	3Q4G	99.6%	Vibrio cholerae

IDP02242 (show subtarget assignments)	1	cloned	No	Cj0320	15791688	fliH	flagellar assembly protein H [Campylobac...	276	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04389 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0617	110799796	pstS	phosphate ABC transporter, phosphate-bin...	276	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	32.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP04650 (show subtarget assignments)	1	expressed	No	FTT1302	56708360		hypothetical protein FTT_1302 [Francisel...	276	drug target; conserved gene;	Phase 4: April 2009	3GBP	88.3%	Francisella tularensis

IDP02708 (show subtarget assignments)	1	cloned	No	lmo0291	16802337		hypothetical protein lmo0291 [Listeria m...	276	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2DKF	13.4%	Listeria monocytogenes	Cellular processes	Toxin production and resistance

IDP00007 (show subtarget assignments)	0	work_stopped	No	BA_0847	30254435	racE-1	glutamate racemase	276	Drug Target Homolog	Phase 1: October 2007	2DWU	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04262 (show subtarget assignments)	1	cloned	No	CPF_2067	110799430	spo0A	Spo0A protein [Clostridium perfringens A...	276	conserved gene; putative drug target function;	Phase 4: April 2009	1LQ1	31.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP02014 (show subtarget assignments)	1	soluble	No	STM2341	16765668		putative transketolase [Salmonella typhi...	276	Conserved; Drug target functions	Phase 3: June 2008	2E6K	33%	Salmonella enterica	Energy metabolism	Pentose phosphate pathway

IDP02641 (show subtarget assignments)	1	purified	No	GBAA0640	47525919		amino acid ABC transporter amino acid-bi...	276	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2V25	33.3%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01701 (show subtarget assignments)	1	soluble	No	CBU_1970	29542525	dapF	diaminopimelate epimerase [Coxiella burn...	276	Conserved; Drug target functions	Phase 3: June 2008	1GQZ	48.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP05563 (show subtarget assignments)	1	soluble	No	lmo2417	16804455	-	hypothetical protein lmo2417 [Listeria m...	276	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4EF1	50.4%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP00163 (show subtarget assignments)	0	work_stopped	No	VC0838	15640855	tcpN/toxT	TCP pilus virulence regulatory protein	276	Virulence	Phase 1: October 2007	3GBG	100%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01342 (show subtarget assignments)	1	soluble	No	VC1960	15641962		septum site-determining protein MinD	276	Conserved Gene / Pathway	Phase 2: March 2008	3Q9L	73.6%	Vibrio cholerae	Cellular processes	Cell division

IDP91961 (show subtarget assignments)	8	in_pdb 4EQ9	No	SpneCM_010100005438	298255041		ABC transporter substrate-binding protei...	276	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	4EQ9	88%	Streptococcus pneumoniae

IDP02477 (show subtarget assignments)	1	cloned	No	YPO2035	16122274		hypothetical protein YPO2035 [Yersinia p...	276	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1ZCC	23.6%	Yersinia pestis	Central intermediary metabolism	Other

IDP02472 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3785	16123919		hypothetical protein YPO3785 [Yersinia p...	276	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1YWF	26.2%	Yersinia pestis	Energy metabolism	Sugars

IDP90512 (show subtarget assignments)	8	in_crystallization_trials	No	Q9KVL6	21362496		RecName: Full=Diaminopimelate epimerase;...	276	Predicted Essential	Community Requests	1BWZ	73.6%	Vibrio cholerae

IDP90651 (show subtarget assignments)	8	expressed	No	YPO3314	16123467		putative N-terminal region of transketol...	276	Predicted Essential	Community Requests	3OOY	34.4%	Yersinia pestis

IDP04360 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2018	115347740		putative protoporphyrinogen oxidase [Yer...	276	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1T43	62.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04707 (show subtarget assignments)	1	cloned	No	BAS0113	49183147		50S ribosomal protein L2 [Bacillus anthr...	276	Proposed to be essential proteins	Phase 4: April 2009	1VSA	65%	Bacillus anthracis

IDP04374 (show subtarget assignments)	1	crystallized	No	YPO3501	218930515	folP	dihydropteroate synthase [Yersinia pesti...	277	conserved gene; putative drug target function;	Phase 4: April 2009	3TYU	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00974 (show subtarget assignments)	1	in_crystallization_trials	No	STM1775	16765116	hemK	N5-glutamine S-adenosyl-L-methionine-dep...	277	Essential Gene	Phase 2: March 2008	1T43	76.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04688 (show subtarget assignments)	1	soluble	No	GBAA4661	47529959	nadC	nicotinate-nucleotide pyrophosphorylase ...	277	putative drug target function;	Phase 4: April 2009	1X1O	43.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP01630 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1964	29542519	hemK	protein methyltransferase HemK [Coxiella...	277	Conserved; Drug target functions	Phase 3: June 2008	1T43	42.6%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP05701 (show subtarget assignments)	1	soluble	No	lmo2522	16804560	-	hypothetical protein lmo2522 [Listeria m...	277	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05199 (show subtarget assignments)	1	soluble	No	CD1556	126699160		putative polysaccharide deacetylase [Clo...	277	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	22.7%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP90189 (show subtarget assignments)	8	cloned	No	AAM13616.1	20153155	CPXV175 CDS	CPXV175 protein	277	CD47-like putative membrane protein	Community Requests	2JJS	13%	Cowpox virus	host defense modulator	0

IDP90133 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_159	68449233		CD47-like putative membrane protein [Mon...	277	similar to VACV-COP-A38L, MPXV-ZAI96-A40L	Community Requests	2JJS	11.6%	Monkeypox virus

IDP90852 (show subtarget assignments)	8	expressed	No	VC2018	15642020		4-amino-4-deoxychorismate lyase [Vibrio ...	277	Predicted Essential	Community Requests	1ET0	34.3%	Vibrio cholerae

IDP04547 (show subtarget assignments)	1	cloned	No	CPF_0581	110800184		amino acid ABC transporter, amino acid-b...	278	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PVU	30.2%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP02020 (show subtarget assignments)	1	crystallized	No	FTT0245	56707402	usp	universal stress protein [Francisella tu...	278	Drug Target	Phase 3: June 2008	2PFS	20.5%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP00217 (show subtarget assignments)	1	cloned	No	YPO2319	16122543	-	putative pepetidase	278	Virulence	Phase 1: October 2007	1AGJ	24.1%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP05596 (show subtarget assignments)	1	cloned	No	BA_3366	30257909		putative lipoprotein [Bacillus anthracis...	278	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP00046 (show subtarget assignments)	1	in_pdb 3FOB	Yes	BA_3165	30257736		bromoperoxidase	278	Virulence	Phase 1: October 2007	3FOB	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP90940 (show subtarget assignments)	8	cloned	No	NMPDR 243277.1.peg.3912				278	Predicted Essential	Community Requests	1DD8	61.9%	Vibrio cholerae

IDP91191
(show subtarget assignments)

1

in_pdb
4EJ7
3R78

No

CAJ77079

90265397

aphA1

Aminoglycoside phosphotransferase [Acine...

271

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3R78

100%

Acinetobacter baumannii

IDP91966
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100001092

298254195

ABC transporter substrate-binding protei...

271

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1GGG

28.4%

Streptococcus pneumoniae

IDP05446
(show subtarget assignments)

1

soluble

No

lmo1738

16803778

-

hypothetical protein lmo1738 [Listeria m...

271

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HV1

49.4%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP90656
(show subtarget assignments)

8

purified

No

Cj0384c

15791751

kdsA

2-dehydro-3-deoxyphosphooctonate aldolas...

271

Predicted Essential

Community Requests

1FWN

55.7%

Campylobacter jejuni

IDP02027
(show subtarget assignments)

1

soluble

No

CBU_0599

29541200

cysQ-1

3'(2'),5'-bisphosphate nucleotidase [Cox...

271

Conserved; Drug target functions

Phase 3: June 2008

3B8B

39.5%

Coxiella burnetii

Central intermediary metabolism

Sulfur metabolism

IDP05269
(show subtarget assignments)

1

soluble

No

lmo0517

16802560

-

hypothetical protein lmo0517 [Listeria m...

271

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3R7A

39.1%

Listeria monocytogenes

Energy metabolism: Glycolysis/gluconeogenesis

IDP04274
(show subtarget assignments)

1

cloned

No

YPCD1.49

16082737

virF

transcriptional regulator [Yersinia pest...

271

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

3OIO

11.8%

Yersinia pestis

Regulatory functions

Other

IDP01785
(show subtarget assignments)

1

expressed

No

CBU_0667

29541271

dapD

2,3,4,5-tetrahydropyridine-2,6-dicarboxy...

271

Conserved; Drug target functions

Phase 3: June 2008

1KGQ

62.7%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01763
(show subtarget assignments)

1

cloned

No

YPO3627

16123769

ssuB

aliphatic sulfonates transport ATP-bindi...

271

Conserved; CD; Drug target functions

Phase 3: June 2008

2IT1

35.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP04232
(show subtarget assignments)

1

cloned

No

CPF_0693

110799915

aroE

shikimate 5-dehydrogenase [Clostridium p...

271

conserved gene; putative drug target function;

Phase 4: April 2009

3FBT

46.9%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP91012
(show subtarget assignments)

8

expressed

No

y2259

22126145

hypothetical protein y2259 [Yersinia pes...

271

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

Yersinia pestis

IDP05049
(show subtarget assignments)

1

soluble

No

BA_5058

30259547

putative lipoprotein [Bacillus anthracis...

271

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP04727
(show subtarget assignments)

1

purified

No

CPF_2072

110800396

hemolysin A [Clostridium perfringens ATC...

271

conserved gene; putative drug target function;

Phase 4: April 2009

3HP7

49.8%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP91800
(show subtarget assignments)

8

in_crystallization_trials

No

p6418_01

219372022

sul2

dihydropteroate synthase [Escherichia co...

271

drug resistance / Deactivates antibiotic sulfonamide by ligating on p-aminobenzoic acid; we will c...

Community Requests

2Y5J

38.1%

Escherichia coli

IDP00732
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2473

57286467

peptide ABC transporter, ATP-binding pro...

271

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

31.7%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP01370
(show subtarget assignments)

1

purified

No

VC0247

15640277

lipopolysaccharide/O-antigen transport p...

271

Conserved Gene / Pathway

Phase 2: March 2008

1OXS

25.8%

Vibrio cholerae

Transport and binding proteins

Other

IDP91718
(show subtarget assignments)

8

selected

No

NP_060140

109148508

OTUB1

ubiquitin thioesterase OTUB1 [Homo sapie...

271

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

4DDG

90.8%

Homo sapiens

IDP00615
(show subtarget assignments)

1

expressed

No

SACOL1160

57284445

sdhB

succinate dehydrogenase iron-sulfur subu...

271

Conserved Gene / Pathway

Phase 2: March 2008

1E7P

25.1%

Staphylococcus aureus

Energy metabolism

TCA cycle

IDP01150
(show subtarget assignments)

1

expressed

No

BA_4493

34582388

Phosphate import ATP-binding protein pst...

271

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

32.8%

Bacillus anthracis

Transport and binding proteins

Anions

IDP01128
(show subtarget assignments)

1

expressed

No

BA_4595

30259095

iron compound ABC transporter, ATP-bindi...

272

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

29.8%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP91167
(show subtarget assignments)

8

expressed

No

STM3401

16766690

aroE

shikimate 5-dehydrogenase

272

potential drug target / Shikimate pathway enzyme

Community Requests

1NYT

84.9%

Salmonella enterica

IDP04390
(show subtarget assignments)

1

cloned

No

CPF_0618

110799563

pstS

phosphate ABC transporter, phosphate-bin...

272

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

36.4%

Clostridium perfringens

Transport and binding proteins

Anions

IDP05091
(show subtarget assignments)

1

cloned

No

CD0256

126697828

motA

chemotaxis protein [Clostridium difficil...

272

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP90783
(show subtarget assignments)

8

cloned

No

YPO0649

16120974

uppP

undecaprenyl pyrophosphate phosphatase [...

272

Predicted Essential

Community Requests

Yersinia pestis

IDP90926
(show subtarget assignments)

8

purified

No

STM3859

16767143

aroE

shikimate 5-dehydrogenase [Salmonella ty...

272

Predicted Essential

Community Requests

1NPY

55.5%

Salmonella enterica

IDP01841
(show subtarget assignments)

1

purified

No

STM2549

16765869

asrB

anaerobic sulfite reductase subunit B [S...

272

Conserved; Drug target functions

Phase 3: June 2008

1KRH

18.8%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01780
(show subtarget assignments)

1

in_crystallization_trials

No

STM0784

16764148

ybhA

phosphotransferase [Salmonella typhimuri...

272

Conserved; Drug target functions

Phase 3: June 2008

2PQ0

30.5%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP05765
(show subtarget assignments)

1

soluble

No

lmo2812

16804849

-

hypothetical protein lmo2812 [Listeria m...

272

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IT9

32%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00174
(show subtarget assignments)

1

cloned

No

YPO1140

16121437

-

putative membrane protein

272

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Unknown function

General

IDP90631
(show subtarget assignments)

8

expressed

No

YPO2526

16122745

acyl-CoA thioester hydrolase YfbB [Yersi...

272

Predicted Essential

Community Requests

1R3D

42.3%

Yersinia pestis

IDP91186
(show subtarget assignments)

1

in_crystallization_trials

No

CAA37605

47078

unnamed protein product [Streptomyces gr...

272

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ND4

39.8%

Streptomyces griseus

IDP02433
(show subtarget assignments)

1

expressed

No

CBU_0010

29540636

aroE

shikimate 5-dehydrogenase [Coxiella burn...

272

Conserved; Drug target functions

Phase 3: June 2008

1NYT

46.3%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01127
(show subtarget assignments)

1

expressed

No

BA_0618

30254221

iron compound ABC transporter, ATP-bindi...

273

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

29.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP05506
(show subtarget assignments)

1

soluble

No

CD1232

126698828

putative lipoprotein [Clostridium diffic...

273

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1NA0

15.8%

Clostridium difficile

Unknown function: General

IDP00538
(show subtarget assignments)

1

in_pdb
3GVD

No

YPO0070

16120421

cysE

serine acetyltransferase

273

Drug Target Function

Phase 2: March 2008

3GVD

100%

Yersinia pestis

Amino acid biosynthesis

Serine family

IDP05547
(show subtarget assignments)

1

soluble

No

lmo0285

16802331

-

putative lipoprotein [Listeria monocytog...

273

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TQW

41%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP90934
(show subtarget assignments)

8

crystallized

No

YPO0480

16120810

dapB

dihydrodipicolinate reductase [Yersinia ...

273

Predicted Essential

Community Requests

1ARZ

79.5%

Yersinia pestis

IDP91168
(show subtarget assignments)

8

purified

No

lmo1490

16803530

-

similar to shikimate 5-dehydrogenase (Ar...

273

potential drug target / Shikimate pathway enzyme

Community Requests

3DON

45.6%

Listeria monocytogenes

IDP01738
(show subtarget assignments)

1

cloned

No

STM1484

16764829

putative protease [Salmonella typhimuriu...

273

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP05408
(show subtarget assignments)

1

soluble

No

BA_1977

30256632

putative polysaccharide deacetylase [Bac...

273

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

31.1%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01343
(show subtarget assignments)

1

cloned

No

VC2649

15642644

cysE

serine acetyltransferase

273

Drug Target Function

Phase 2: March 2008

1T3D

72.2%

Vibrio cholerae

Amino acid biosynthesis

Serine family

IDP01333
(show subtarget assignments)

1

purified

No

VC0726

15640745

phosphate ABC transporter, ATP-binding p...

273

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

33%

Vibrio cholerae

Transport and binding proteins

Anions

IDP92081
(show subtarget assignments)

8

selected

No

TGME49_106970

237845145

thymidylate kinase, putative [Toxoplasma...

273

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1E2D

35.2%

Toxoplasma gondii

IDP91731
(show subtarget assignments)

8

selected

No

NP_958854

41393583

EGFL7

epidermal growth factor-like protein 7 [...

273

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2W86

15.8%

Homo sapiens

IDP00571
(show subtarget assignments)

1

in_pdb
3GOS

No

YPO1041

16121341

dapD

2,3,4,5-tetrahydropyridine-2-carboxylate...

274

Virulence Associated Factor

Phase 2: March 2008

3GOS

100%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02179
(show subtarget assignments)

1

soluble

No

CBU_2090

29542640

proC

pyrroline-5-carboxylate reductase [Coxie...

274

Conserved; Drug target functions

Phase 3: June 2008

3TRI

100%

Coxiella burnetii

Amino acid biosynthesis

Glutamate family

IDP02121
(show subtarget assignments)

1

cloned

No

FTT0360

56707511

Short-chain dehydrogenase/reductase [Fra...

274

Drug Target

Phase 3: June 2008

1FDW

27.7%

Francisella tularensis

Central intermediary metabolism

Other

IDP02803
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1960

16803999

fhuC

hypothetical protein lmo1960 [Listeria m...

274

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1B0U

28.5%

Listeria monocytogenes

Transport and binding proteins

Cations and iron carrying compounds

IDP90765
(show subtarget assignments)

8

purified

No

Cj1536c

15792844

galU

UTP-glucose-1-phosphate uridylyltransfer...

274

Predicted Essential

Community Requests

3JUJ

60.6%

Campylobacter jejuni

IDP00477
(show subtarget assignments)

1

purified

No

YPO3845

16123980

dapF

diaminopimelate epimerase

274

Conserved Gene / Pathway

Phase 2: March 2008

1GQZ

75.9%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP05313
(show subtarget assignments)

1

soluble

No

BA_1061

30254794

putative lipoprotein [Bacillus anthracis...

274

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP01751
(show subtarget assignments)

0

work_stopped

No

Cj1312

15792635

flagellar protein [Campylobacter jejuni ...

274

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

3HBM

99.6%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP90705
(show subtarget assignments)

8

soluble

No

Cj1400c

15792718

fabI

enoyl-(acyl carrier protein) reductase [...

274

Predicted Essential

Community Requests

2PD3

67.2%

Campylobacter jejuni

IDP04641
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0693c

56707813

mutM

formamidopyrimidine-DNA glycosylase [Fra...

274

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1K82

43.1%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP02521
(show subtarget assignments)

1

soluble

No

Cj1146c

15792471

waaV

lipooligosaccharide biosynthesis glycosy...

274

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3L7I

25.4%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05626
(show subtarget assignments)

1

soluble

No

CD1430

126699034

putative exported polysaccharide deacety...

274

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1NY1

37.2%

Clostridium difficile

Cellular processes: Sporulation and germination

IDP02492
(show subtarget assignments)

1

crystallized

No

FTT1559c

56708586

proC

pyrroline-5-carboxylate reductase [Franc...

274

Conserved; Drug target functions

Phase 3: June 2008

3TRI

37.6%

Francisella tularensis

Amino acid biosynthesis

Glutamate family

IDP00583
(show subtarget assignments)

1

expressed

No

YPO2752

16122956

mepA

penicillin-insensitive murein endopeptid...

275

Drug Target Function

Phase 2: March 2008

1TZP

67.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02706
(show subtarget assignments)

1

cloned

No

FTT0470

56707612

apaH

diadenosine tetraphosphatase [Francisell...

275

Drug Target

Phase 3: June 2008

2DFJ

37.8%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP01049
(show subtarget assignments)

1

in_crystallization_trials

No

STM3183

16766483

icc

cyclic 3',5'-adenosine monophosphate pho...

275

Conserved Gene / Pathway

Phase 2: March 2008

2HY1

25.1%

Salmonella enterica

Central intermediary metabolism

Other

IDP05264
(show subtarget assignments)

1

expressed

No

CD3257

126700876

putative polysaccharide deacetylase [Clo...

275

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1W17

25.5%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00960
(show subtarget assignments)

1

in_pdb
3HMQ

No

STM1310

16764661

nadE

NAD synthetase

275

Drug Target Function

Phase 2: March 2008

3HMQ

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP05683
(show subtarget assignments)

1

cloned

No

lmo1379

16803419

-

OxaA-like protein precursor [Listeria mo...

275

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Cell envelope: Other

IDP92246
(show subtarget assignments)

8

selected

No

EF_2296

2499116

RecName: Full=Vancomycin B-type resistan...

275

drug resistance / Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...

Community Requests

Enterococcus faecalis

IDP05724
(show subtarget assignments)

1

soluble

No

BA_3370

30257913

ribonuclease [Bacillus anthracis str. Am...

275

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Transcription: Degradation of RNA

IDP90843
(show subtarget assignments)

8

in_pdb
3Q4G

Yes

VCA0207

15600976

nadE

NAD synthetase [Vibrio cholerae O1 biova...

276

Predicted Essential

Community Requests

3Q4G

99.6%

Vibrio cholerae

IDP02242
(show subtarget assignments)

1

cloned

No

Cj0320

15791688

fliH

flagellar assembly protein H [Campylobac...

276

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04389
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0617

110799796

pstS

phosphate ABC transporter, phosphate-bin...

276

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

32.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP04650
(show subtarget assignments)

1

expressed

No

FTT1302

56708360

hypothetical protein FTT_1302 [Francisel...

276

drug target; conserved gene;

Phase 4: April 2009

3GBP

88.3%

Francisella tularensis

IDP02708
(show subtarget assignments)

1

cloned

No

lmo0291

16802337

hypothetical protein lmo0291 [Listeria m...

276

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2DKF

13.4%

Listeria monocytogenes

Cellular processes

Toxin production and resistance

IDP00007
(show subtarget assignments)

0

work_stopped

No

BA_0847

30254435

racE-1

glutamate racemase

276

Drug Target Homolog

Phase 1: October 2007

2DWU

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04262
(show subtarget assignments)

1

cloned

No

CPF_2067

110799430

spo0A

Spo0A protein [Clostridium perfringens A...

276

conserved gene; putative drug target function;

Phase 4: April 2009

1LQ1

31.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP02014
(show subtarget assignments)

1

soluble

No

STM2341

16765668

putative transketolase [Salmonella typhi...

276

Conserved; Drug target functions

Phase 3: June 2008

2E6K

33%

Salmonella enterica

Energy metabolism

Pentose phosphate pathway

IDP02641
(show subtarget assignments)

1

purified

No

GBAA0640

47525919

amino acid ABC transporter amino acid-bi...

276

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2V25

33.3%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01701
(show subtarget assignments)

1

soluble

No

CBU_1970

29542525

dapF

diaminopimelate epimerase [Coxiella burn...

276

Conserved; Drug target functions

Phase 3: June 2008

1GQZ

48.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP05563
(show subtarget assignments)

1

soluble

No

lmo2417

16804455

-

hypothetical protein lmo2417 [Listeria m...

276

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4EF1

50.4%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP00163
(show subtarget assignments)

0

work_stopped

No

VC0838

15640855

tcpN/toxT

TCP pilus virulence regulatory protein

276

Virulence

Phase 1: October 2007

3GBG

100%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01342
(show subtarget assignments)

1

soluble

No

VC1960

15641962

septum site-determining protein MinD

276

Conserved Gene / Pathway

Phase 2: March 2008

3Q9L

73.6%

Vibrio cholerae

Cellular processes

Cell division

IDP91961
(show subtarget assignments)

8

in_pdb
4EQ9

No

SpneCM_010100005438

298255041

ABC transporter substrate-binding protei...

276

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

4EQ9

88%

Streptococcus pneumoniae

IDP02477
(show subtarget assignments)

1

cloned

No

YPO2035

16122274

hypothetical protein YPO2035 [Yersinia p...

276

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1ZCC

23.6%

Yersinia pestis

Central intermediary metabolism

Other

IDP02472
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3785

16123919

hypothetical protein YPO3785 [Yersinia p...

276

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1YWF

26.2%

Yersinia pestis

Energy metabolism

Sugars

IDP90512
(show subtarget assignments)

8

in_crystallization_trials

No

Q9KVL6

21362496

RecName: Full=Diaminopimelate epimerase;...

276

Predicted Essential

Community Requests

1BWZ

73.6%

Vibrio cholerae

IDP90651
(show subtarget assignments)

8

expressed

No

YPO3314

16123467

putative N-terminal region of transketol...

276

Predicted Essential

Community Requests

3OOY

34.4%

Yersinia pestis

IDP04360
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2018

115347740

putative protoporphyrinogen oxidase [Yer...

276

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1T43

62.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04707
(show subtarget assignments)

1

cloned

No

BAS0113

49183147

50S ribosomal protein L2 [Bacillus anthr...

276

Proposed to be essential proteins

Phase 4: April 2009

1VSA

65%

Bacillus anthracis

IDP04374
(show subtarget assignments)

1

crystallized

No

YPO3501

218930515

folP

dihydropteroate synthase [Yersinia pesti...

277

conserved gene; putative drug target function;

Phase 4: April 2009

3TYU

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00974
(show subtarget assignments)

1

in_crystallization_trials

No

STM1775

16765116

hemK

N5-glutamine S-adenosyl-L-methionine-dep...

277

Essential Gene

Phase 2: March 2008

1T43

76.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04688
(show subtarget assignments)

1

soluble

No

GBAA4661

47529959

nadC

nicotinate-nucleotide pyrophosphorylase ...

277

putative drug target function;

Phase 4: April 2009

1X1O

43.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP01630
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1964

29542519

hemK

protein methyltransferase HemK [Coxiella...

277

Conserved; Drug target functions

Phase 3: June 2008

1T43

42.6%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP05701
(show subtarget assignments)

1

soluble

No

lmo2522

16804560

-

hypothetical protein lmo2522 [Listeria m...

277

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05199
(show subtarget assignments)

1

soluble

No

CD1556

126699160

putative polysaccharide deacetylase [Clo...

277

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

22.7%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP90189
(show subtarget assignments)

8

cloned

No

AAM13616.1

20153155

CPXV175 CDS

CPXV175 protein

277

CD47-like putative membrane protein

Community Requests

2JJS

13%

Cowpox virus

host defense modulator

0

IDP90133
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_159

68449233

CD47-like putative membrane protein [Mon...

277

similar to VACV-COP-A38L, MPXV-ZAI96-A40L

Community Requests

2JJS

11.6%

Monkeypox virus

IDP90852
(show subtarget assignments)

8

expressed

No

VC2018

15642020

4-amino-4-deoxychorismate lyase [Vibrio ...

277

Predicted Essential

Community Requests

1ET0

34.3%

Vibrio cholerae

IDP04547
(show subtarget assignments)

1

cloned

No

CPF_0581

110800184

amino acid ABC transporter, amino acid-b...

278

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PVU

30.2%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP02020
(show subtarget assignments)

1

crystallized

No

FTT0245

56707402

usp

universal stress protein [Francisella tu...

278

Drug Target

Phase 3: June 2008

2PFS

20.5%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP00217
(show subtarget assignments)

1

cloned

No

YPO2319

16122543

-

putative pepetidase

278

Virulence

Phase 1: October 2007

1AGJ

24.1%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP05596
(show subtarget assignments)

1

cloned

No

BA_3366

30257909

putative lipoprotein [Bacillus anthracis...

278

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP00046
(show subtarget assignments)

1

in_pdb
3FOB

Yes

BA_3165

30257736

bromoperoxidase

278

Virulence

Phase 1: October 2007

3FOB

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP90940
(show subtarget assignments)

8

cloned

No

NMPDR 243277.1.peg.3912

278

Predicted Essential

Community Requests

1DD8

61.9%

Vibrio cholerae