Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91753 (show subtarget assignments)	8	selected	No	TSST_STAAU	0			234	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2IJ0	82.5%	Staphylococcus aureus

IDP91668 (show subtarget assignments)	8	selected	No	Q914E0_9ENTO	0			2194	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2IJD	20.6%	Human echovirus

IDP91667 (show subtarget assignments)	8	selected	No	POLG_CXB3W	0			2185	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2IJD	20.7%	Coxsackievirus B3

IDP02479 (show subtarget assignments)	1	cloned	No	lmo1287	16803327	parC	DNA topoisomerase IV subunit A [Listeria...	819	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	2INR	41.8%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP02344 (show subtarget assignments)	1	cloned	No	FTT0356	56707508	htpG	heat shock protein 90 [Francisella tular...	628	Conserved; Drug target functions	Phase 3: June 2008	2IOP	52.4%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein folding and stabilization

IDP01614 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2581	16122794		putative sugar-binding periplasmic prote...	309	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2IOY	29.5%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02510 (show subtarget assignments)	1	expressed	No	YPO2285	16122509		putative ribose-binding periplasmic prot...	208	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2IOY	35.6%	Yersinia pestis	N/A	N/A

IDP02650 (show subtarget assignments)	1	expressed	No	YPO3962	16124090		sugar-binding transport protein [Yersini...	314	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2IOY	34.7%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP05406 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0669	30254269	rbsB	ribose ABC transporter, ribose-binding p...	308	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IOY	51.9%	Bacillus anthracis	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP02276 (show subtarget assignments)	1	expressed	No	YPO0860	16121168		sugar-binding periplasmic protein [Yersi...	333	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2IOY	26.7%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP05664 (show subtarget assignments)	1	purified	No	lmo0341	16802386	-	hypothetical protein lmo0341 [Listeria m...	110	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IP6	30%	Listeria monocytogenes	Transport and binding proteins: Other

IDP01041 (show subtarget assignments)	1	purified	No	STM2971	16766276	sdaB	L-serine dehydratase/L-threonine deamina...	455	Conserved Gene / Pathway	Phase 2: March 2008	2IQQ	16%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP04420 (show subtarget assignments)	1	cloned	No	GBAA3308	47528594	sdhB-1	l-serine dehydratase, iron-sulfur-depend...	232	virulence factor; putative drug target function;	Phase 4: April 2009	2IQQ	15.5%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02466 (show subtarget assignments)	1	crystallized	No	YPO1771	16122025		L-serine dehydratase [Yersinia pestis CO...	454	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	2IQQ	17%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP90755 (show subtarget assignments)	8	cloned	No	YPO3841	16123976	uvrD	DNA-dependent helicase II [Yersinia pest...	720	Predicted Essential	Community Requests	2IS1	83.3%	Yersinia pestis

IDP90600 (show subtarget assignments)	8	cloned	No	VC0190	15640220	uvrD	DNA-dependent helicase II [Vibrio choler...	723	Predicted Essential	Community Requests	2IS1	66.8%	Vibrio cholerae

IDP05304 (show subtarget assignments)	1	cloned	No	Z1313	12514147	helD	DNA helicase IV [Escherichia coli O157:H...	715	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2IS1	14.3%	Escherichia coli	DNA metabolism: DNA replication, recombination, and repair

IDP00798 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1368	57284523	kataA	catalase	473	Conserved Gene / Pathway	Phase 2: March 2008	2ISA	63.4%	Staphylococcus aureus	Cellular processes	Detoxification

IDP90786 (show subtarget assignments)	8	cloned	No	Cj1385	15792708	katA	catalase [Campylobacter jejuni subsp. je...	474	Predicted Essential	Community Requests	2ISA	57.8%	Campylobacter jejuni

IDP01694 (show subtarget assignments)	1	purified	No	YPO3335	16123488	fumA	fumarate hydratase, class I [Yersinia pe...	547	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2ISB	10.1%	Yersinia pestis	Energy metabolism	TCA cycle

IDP02526 (show subtarget assignments)	1	cloned	No	FTT1600c	56708620	fumA	fumerate hydratase [Francisella tularens...	504	Drug Target	Phase 3: June 2008	2ISB	13.7%	Francisella tularensis	Energy metabolism	TCA cycle

IDP01128 (show subtarget assignments)	1	expressed	No	BA_4595	30259095		iron compound ABC transporter, ATP-bindi...	272	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	29.8%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01763 (show subtarget assignments)	1	cloned	No	YPO3627	16123769	ssuB	aliphatic sulfonates transport ATP-bindi...	271	Conserved; CD; Drug target functions	Phase 3: June 2008	2IT1	35.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00811 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1873	57284794	epiF	epidermin immunity protein F	230	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	33.6%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP01490 (show subtarget assignments)	1	expressed	No	VCA0602	15601360		ABC transporter, ATP-binding protein	403	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	34%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP00730 (show subtarget assignments)	1	soluble	No	SACOL2453	57286449		amino acid ABC transporter, ATP-binding ...	408	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	27.5%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00721 (show subtarget assignments)	1	expressed	No	SACOL1613	57286135		ABC transporter, ATP-binding protein	261	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	31.8%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP00704 (show subtarget assignments)	1	expressed	No	SACOL0264	57286724		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	32%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01389 (show subtarget assignments)	1	purified	No	VC0610	15640630		iron(III) ABC transporter, ATP-binding p...	343	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	36.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00635 (show subtarget assignments)	1	cloned	No	SACOL2270	57286396	modC	molybdenum ABC transporter, ATP-binding ...	201	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	38.8%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP01928 (show subtarget assignments)	1	cloned	No	FTT0286c	56707440	lpxD1	UDP-3-O-[3-hydroxymyristoyl] glucosamine...	347	Drug Target	Phase 3: June 2008	2IU8	33.4%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90716 (show subtarget assignments)	8	soluble	No	Cj0576	15791936	lpxD	UDP-3-O-[3-hydroxymyristoyl] glucosamine...	321	Predicted Essential	Community Requests	2IU8	35.5%	Campylobacter jejuni

IDP04398 (show subtarget assignments)	1	cloned	No	YPO1376	218928524	ftsK	putative cell division protein [Yersinia...	1305	drug target; putative drug target function;	Phase 4: April 2009	2IUS	33.3%	Yersinia pestis	Cellular processes	Cell division

IDP91892 (show subtarget assignments)	8	selected	No	SpneCM_010100009040	298255720		DNA translocase ftsk [Streptococcus pneu...	741	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2IUT	33.5%	Streptococcus pneumoniae

IDP02312 (show subtarget assignments)	1	expressed	No	GBAA2190	47778017		FtsK/SpoIIIE family protein [Bacillus an...	1342	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2IUT	7.4%	Bacillus anthracis	Cellular processes	Cell division

IDP01065 (show subtarget assignments)	1	expressed	No	STM3722	16767007	rfaG	glucosyltransferase I	374	Drug Target Function	Phase 2: March 2008	2IV7	86.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01952 (show subtarget assignments)	1	cloned	No	Cj1432c	15792750		putative sugar transferase [Campylobacte...	1031	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2IV7	7.7%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90847 (show subtarget assignments)	8	selected	No	S4100	30065095	waaG	LPS alpha1,3-glucosyltransferase [Shigel...	374	Predicted Essential	Community Requests	2IV7	89.8%	Shigella flexneri

IDP01784 (show subtarget assignments)	1	expressed	No	STM1383	16764733	ttrA	tetrathionate reductase complex subunit ...	1020	Conserved; Drug target functions	Phase 3: June 2008	2IVF	18.1%	Salmonella enterica	Energy metabolism	Electron transport

IDP02021 (show subtarget assignments)	1	cloned	No	CBU_1240	29541810	gcp	O-sialoglycoprotein endopeptidase [Coxie...	339	Conserved; Drug target functions	Phase 3: June 2008	2IVN	36%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00448 (show subtarget assignments)	1	purified	No	YPO0646	16120971	gcp	O-sialoglycoprotein endopeptidase	337	Drug Target Function	Phase 2: March 2008	2IVN	35.6%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01702 (show subtarget assignments)	1	soluble	No	GBAA0261	47525520	gcP	O-sialoglycoprotein endopeptidase [Bacil...	338	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2IVN	35.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02747 (show subtarget assignments)	1	soluble	No	FTT0147	56707317	gcp	O-sialoglycoprotein endopeptidase [Franc...	336	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2IVN	35.1%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00687 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2038	57284907		O-sialoglycoprotein endopeptidase	341	Drug Target Function	Phase 2: March 2008	2IVN	30.2%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01470 (show subtarget assignments)	1	purified	No	VC2608	15642603		ABC transporter, ATP-binding protein	664	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	23.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP00727 (show subtarget assignments)	1	cloned	No	SACOL2036	57284905		ABC transporter, ATP-binding protein	642	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	24.1%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP00708 (show subtarget assignments)	1	expressed	No	SACOL0779	57285742		ABC transporter, ATP-binding protein	625	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	22.2%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP02426 (show subtarget assignments)	1	cloned	No	CBU_1952	29542507		ABC transporter, ATP-binding protein [Co...	532	Conserved; Drug target functions	Phase 3: June 2008	2IW3	26.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP91022 (show subtarget assignments)	8	cloned	No	y2966	22126843	ompC	outer membrane porin protein C [Yersinia...	374	drug resistance / outer membrane porin	Community Requests	2IXX	67.9%	Yersinia pestis

IDP01208 (show subtarget assignments)	1	expressed	No	BA_2638	30257255		glycosyl transferase, putative	387	Essential Gene	Phase 2: March 2008	2IYA	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00552 (show subtarget assignments)	1	soluble	No	YPO0282	16120621	hmuS	hemin transport protein	345	Conserved Gene / Pathway	Phase 2: March 2008	2J0R	89.6%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP01080 (show subtarget assignments)	0	work_stopped	No	STM4220	16767470	lysC	aspartate kinase III	449	Conserved Gene / Pathway	Phase 2: March 2008	2J0W	93.1%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP05526 (show subtarget assignments)	1	soluble	No	CD1319	126698918		putative polysaccharide deacetylase [Clo...	247	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2J13	27.1%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP04266 (show subtarget assignments)	1	cloned	No	CPF_2122	110798774	pdaA	delta-lactam-biosynthetic de-N-acetylase...	265	conserved gene; putative drug target function;	Phase 4: April 2009	2J13	41.5%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05732 (show subtarget assignments)	1	cloned	No	CD1205	126698801	ispA	geranyltranstransferase [Clostridium dif...	295	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2J1P	45.8%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone

IDP01148 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1159	30254878	katB	catalase	488	Conserved Gene / Pathway	Phase 2: March 2008	2J2M	64.8%	Bacillus anthracis	Cellular processes	Detoxification

IDP05133 (show subtarget assignments)	1	cloned	No	CD0264	126697836	flhF	flagellar biosynthesis regulator FlhF [C...	338	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2J37	26%	Clostridium difficile	Protein fate: Protein and peptide secretion and trafficking

IDP90551 (show subtarget assignments)	8	diffraction	No	VC0875	15640891		prolyl-tRNA synthetase [Vibrio cholerae ...	571	Predicted Essential	Community Requests	2J3L	45.5%	Vibrio cholerae

IDP90927 (show subtarget assignments)	8	in_crystallization_trials	No	YPO1068	16121369	proS	prolyl-tRNA synthetase [Yersinia pestis ...	572	Predicted Essential	Community Requests	2J3L	47.2%	Yersinia pestis

IDP04603 (show subtarget assignments)	1	in_crystallization_trials	No	BAS3670	49186669		prolyl-tRNA synthetase [Bacillus anthrac...	566	Proposed to be essential proteins	Phase 4: April 2009	2J3L	58.1%	Bacillus anthracis

IDP05650 (show subtarget assignments)	1	soluble	No	Cj0543	6968007	proS	hypothetical protein Cj0539 [Campylobact...	569	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2J3L	42.8%	Campylobacter jejuni	Protein synthesis: tRNA aminoacylation

IDP90581 (show subtarget assignments)	8	soluble	No	Cj0543	15791904	proS	prolyl-tRNA synthetase [Campylobacter je...	569	Predicted Essential	Community Requests	2J3L	42.8%	Campylobacter jejuni

IDP05230 (show subtarget assignments)	1	soluble	No	lmo1319	16803359	proS	prolyl-tRNA synthetase [Listeria monocyt...	568	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2J3L	63%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05337 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1282	57651833	proS	prolyl-tRNA synthetase [Staphylococcus a...	567	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2J3L	55.7%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP91709 (show subtarget assignments)	8	selected	No	NP_006107	5174703	TAB1	TGF-beta-activated kinase 1 and MAP3K7-b...	504	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2J4O	79.6%	Homo sapiens

IDP91386 (show subtarget assignments)	8	cloned	No	VV1_1450	27364835		cell shape-determining protein [Vibrio v...	296	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2J5U	19.3%	Vibrio vulnificus

IDP00802 (show subtarget assignments)	1	cloned	No	SACOL1704	57284716	mreC	rod shape-determining protein MreC	280	Conserved Gene / Pathway	Phase 2: March 2008	2J5U	29.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05624 (show subtarget assignments)	1	expressed	No	CD1146	126698741	mreC	putative rod shape-determining protein [...	297	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2J5U	25.3%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00274 (show subtarget assignments)	1	selected	No	AF180817_2494-3392	7329982	N/A	NS5 methyl transferase and RNA polymeras...	830	RNA-dependent RNA polymerase	Phase 3: June 2008	2J7U	55.5%	Dengue virus	Transcription	N/A

IDP00268 (show subtarget assignments)	1	cloned	No	AAX48017_2488-3387	61652905	N/A	NS5 methyl transferase and RNA polymeras...	900	RNA-dependent RNA polymerase	Phase 3: June 2008	2J7U	54.7%	Dengue virus	Transcription	N/A

IDP91056 (show subtarget assignments)	8	expressed	No	AAA42941	323448		viral polyprotein [Dengue virus 2]	3391	potential drug target / A structure of the co-complex between Dengue 2 strain 16681 full length NS3 and ...	Community Requests	2J7U	15.1%	Dengue virus

IDP04498 (show subtarget assignments)	1	purified	No	VC0791	15640810		sensor kinase citA [Vibrio cholerae O1 b...	565	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2J80	9.7%	Vibrio cholerae	Regulatory functions	Other

IDP91553 (show subtarget assignments)	8	expressed	No	BAB38471	13364525	ECs5048	hypothetical protein [Escherichia coli O...	430	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2J8K	10.5%	Escherichia coli

IDP90218 (show subtarget assignments)	8	soluble	No	MYXV_gp151	9633783	m148R	m148R	675	ankyrin motif, similar to VACV-Cop:B4R	Community Requests	2J8S	6.1%	Myxoma virus	host range factor	0

IDP04255 (show subtarget assignments)	1	cloned	No	CPF_1922	110799469	purB	adenylosuccinate lyase [Clostridium perf...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2J91	56.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02345 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1220	56708282		5-formyltetrahydroformate cycloligase fa...	182	Drug Target	Phase 3: June 2008	2JCB	28.6%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP01241 (show subtarget assignments)	1	expressed	No	BA_1474	30255405		penicillin-binding protein	673	Drug Target Function	Phase 2: March 2008	2JCH	28.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91663 (show subtarget assignments)	8	selected	No	NP_005550	38788416	LAMA1	laminin subunit alpha-1 precursor [Homo ...	3075	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2JD4	9.4%	Homo sapiens

IDP01129 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5296	30259774		ferritin	168	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	48.2%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00611 (show subtarget assignments)	1	crystallized	No	SACOL1952	57286299		ferritins family protein	166	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	39.2%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP01362 (show subtarget assignments)	1	purified	No	VC0158	15640188		glutamate racemase	265	Drug Target Function	Phase 2: March 2008	2JFN	49.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00597 (show subtarget assignments)	1	purified	No	YPO3909	16124041	murI	glutamate racemase	287	Conserved Gene / Pathway	Phase 2: March 2008	2JFN	71.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00328 (show subtarget assignments)	1	in_pdb 3UHP 3UHF 3UHO	No	Cj1652c	15792957	murI	glutamate racemase	250	Drug Target Function	Phase 2: March 2008	2JFX	53.7%	Campylobacter jejuni	Energy metabolism	Pentose phosphate pathway

IDP00567 (show subtarget assignments)	0	work_stopped	No	YPO1113	16121413	kgd	alpha-ketoglutarate decarboxylase	935	Virulence Associated Factor	Phase 2: March 2008	2JGD	87.8%	Yersinia pestis	Energy metabolism	TCA cycle

IDP04395 (show subtarget assignments)	1	cloned	No	FTT0076	56707255	sucA	2-oxoglutarate dehydrogenase E1 componen...	941	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2JGD	47.8%	Francisella tularensis

IDP90680 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1401c	15792719	tpiA	triosephosphate isomerase [Campylobacter...	223	Predicted Essential	Community Requests	2JGQ	48.2%	Campylobacter jejuni

IDP90938 (show subtarget assignments)	8	cloned	No	NMPDR 243277.1.peg.3917				218	Predicted Essential	Community Requests	2JGV	22.5%	Vibrio cholerae

IDP01064 (show subtarget assignments)	1	cloned	No	STM3719	16767004	rfaB	UDP-D-galactose:(glucosyl)lipopolysaccha...	359	Essential Gene	Phase 2: March 2008	2JJM	13.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02796 (show subtarget assignments)	1	cloned	No	Cj1127c	15792452	wlaE	general glycosylation pathway protein [C...	365	Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...	Phase 3: June 2008	2JJM	23.7%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00834 (show subtarget assignments)	1	expressed	No	SACOL2670	57286574		glycosyl transferase, group 1 family pro...	502	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	10.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00788 (show subtarget assignments)	1	crystallized	No	SACOL1043	57284414		glycosyl transferase, group 1 family pro...	493	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	16.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00776 (show subtarget assignments)	1	crystallized	No	SACOL0612	57285627		glycosyl transferase, group 1 family pro...	496	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	11.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00775 (show subtarget assignments)	1	purified	No	SACOL0611	57285626		glycosyl transferase, group 1 family pro...	490	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	14.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01239 (show subtarget assignments)	1	cloned	No	BA_5670	30260118		glycosyl transferase, group 1 family pro...	366	Drug Target Function	Phase 2: March 2008	2JJM	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01185 (show subtarget assignments)	1	cloned	No	BA_0280	30253775		glycosyl transferase, group 1 family pro...	443	Drug Target Function	Phase 2: March 2008	2JJM	13.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05194 (show subtarget assignments)	1	cloned	No	CD0843	126698423		putative glycosyl transferase [Clostridi...	411	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2JJM	19.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02634 (show subtarget assignments)	1	cloned	No	Cj1125c	15792450	wlaG	general glycosylation pathway protein [C...	376	Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...	Phase 3: June 2008	2JJM	22.6%	Campylobacter jejuni	Cellular processes	Chemotaxis and motility

IDP04455 (show subtarget assignments)	1	expressed	No	YPO1336	115347097		putative RNA methyltransferase [Yersinia...	376	conserved gene; putative drug target function;	Phase 4: April 2009	2JJQ	27.7%	Yersinia pestis	Amino acid biosynthesis	Serine family

IDP90189 (show subtarget assignments)	8	cloned	No	AAM13616.1	20153155	CPXV175 CDS	CPXV175 protein	277	CD47-like putative membrane protein	Community Requests	2JJS	13%	Cowpox virus	host defense modulator	0

IDP90133 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_159	68449233		CD47-like putative membrane protein [Mon...	277	similar to VACV-COP-A38L, MPXV-ZAI96-A40L	Community Requests	2JJS	11.6%	Monkeypox virus

IDP91753
(show subtarget assignments)

8

selected

No

TSST_STAAU

0

234

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2IJ0

82.5%

Staphylococcus aureus

IDP91668
(show subtarget assignments)

8

selected

No

Q914E0_9ENTO

0

2194

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2IJD

20.6%

Human echovirus

IDP91667
(show subtarget assignments)

8

selected

No

POLG_CXB3W

0

2185

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2IJD

20.7%

Coxsackievirus B3

IDP02479
(show subtarget assignments)

1

cloned

No

lmo1287

16803327

parC

DNA topoisomerase IV subunit A [Listeria...

819

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

2INR

41.8%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP02344
(show subtarget assignments)

1

cloned

No

FTT0356

56707508

htpG

heat shock protein 90 [Francisella tular...

628

Conserved; Drug target functions

Phase 3: June 2008

2IOP

52.4%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein folding and stabilization

IDP01614
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2581

16122794

putative sugar-binding periplasmic prote...

309

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2IOY

29.5%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02510
(show subtarget assignments)

1

expressed

No

YPO2285

16122509

putative ribose-binding periplasmic prot...

208

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2IOY

35.6%

Yersinia pestis

N/A

IDP02650
(show subtarget assignments)

1

expressed

No

YPO3962

16124090

sugar-binding transport protein [Yersini...

314

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2IOY

34.7%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP05406
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0669

30254269

rbsB

ribose ABC transporter, ribose-binding p...

308

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IOY

51.9%

Bacillus anthracis

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP02276
(show subtarget assignments)

1

expressed

No

YPO0860

16121168

sugar-binding periplasmic protein [Yersi...

333

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2IOY

26.7%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP05664
(show subtarget assignments)

1

purified

No

lmo0341

16802386

-

hypothetical protein lmo0341 [Listeria m...

110

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IP6

30%

Listeria monocytogenes

Transport and binding proteins: Other

IDP01041
(show subtarget assignments)

1

purified

No

STM2971

16766276

sdaB

L-serine dehydratase/L-threonine deamina...

455

Conserved Gene / Pathway

Phase 2: March 2008

2IQQ

16%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP04420
(show subtarget assignments)

1

cloned

No

GBAA3308

47528594

sdhB-1

l-serine dehydratase, iron-sulfur-depend...

232

virulence factor; putative drug target function;

Phase 4: April 2009

2IQQ

15.5%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02466
(show subtarget assignments)

1

crystallized

No

YPO1771

16122025

L-serine dehydratase [Yersinia pestis CO...

454

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

2IQQ

17%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP90755
(show subtarget assignments)

8

cloned

No

YPO3841

16123976

uvrD

DNA-dependent helicase II [Yersinia pest...

720

Predicted Essential

Community Requests

2IS1

83.3%

Yersinia pestis

IDP90600
(show subtarget assignments)

8

cloned

No

VC0190

15640220

uvrD

DNA-dependent helicase II [Vibrio choler...

723

Predicted Essential

Community Requests

2IS1

66.8%

Vibrio cholerae

IDP05304
(show subtarget assignments)

1

cloned

No

Z1313

12514147

helD

DNA helicase IV [Escherichia coli O157:H...

715

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2IS1

14.3%

Escherichia coli

DNA metabolism: DNA replication, recombination, and repair

IDP00798
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1368

57284523

kataA

catalase

473

Conserved Gene / Pathway

Phase 2: March 2008

2ISA

63.4%

Staphylococcus aureus

Cellular processes

Detoxification

IDP90786
(show subtarget assignments)

8

cloned

No

Cj1385

15792708

katA

catalase [Campylobacter jejuni subsp. je...

474

Predicted Essential

Community Requests

2ISA

57.8%

Campylobacter jejuni

IDP01694
(show subtarget assignments)

1

purified

No

YPO3335

16123488

fumA

fumarate hydratase, class I [Yersinia pe...

547

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2ISB

10.1%

Yersinia pestis

Energy metabolism

TCA cycle

IDP02526
(show subtarget assignments)

1

cloned

No

FTT1600c

56708620

fumA

fumerate hydratase [Francisella tularens...

504

Drug Target

Phase 3: June 2008

2ISB

13.7%

Francisella tularensis

Energy metabolism

TCA cycle

IDP01128
(show subtarget assignments)

1

expressed

No

BA_4595

30259095

iron compound ABC transporter, ATP-bindi...

272

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

29.8%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01763
(show subtarget assignments)

1

cloned

No

YPO3627

16123769

ssuB

aliphatic sulfonates transport ATP-bindi...

271

Conserved; CD; Drug target functions

Phase 3: June 2008

2IT1

35.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00811
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1873

57284794

epiF

epidermin immunity protein F

230

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

33.6%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP01490
(show subtarget assignments)

1

expressed

No

VCA0602

15601360

ABC transporter, ATP-binding protein

403

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

34%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP00730
(show subtarget assignments)

1

soluble

No

SACOL2453

57286449

amino acid ABC transporter, ATP-binding ...

408

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

27.5%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00721
(show subtarget assignments)

1

expressed

No

SACOL1613

57286135

ABC transporter, ATP-binding protein

261

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

31.8%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP00704
(show subtarget assignments)

1

expressed

No

SACOL0264

57286724

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

32%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01389
(show subtarget assignments)

1

purified

No

VC0610

15640630

iron(III) ABC transporter, ATP-binding p...

343

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

36.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00635
(show subtarget assignments)

1

cloned

No

SACOL2270

57286396

modC

molybdenum ABC transporter, ATP-binding ...

201

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

38.8%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP01928
(show subtarget assignments)

1

cloned

No

FTT0286c

56707440

lpxD1

UDP-3-O-[3-hydroxymyristoyl] glucosamine...

347

Drug Target

Phase 3: June 2008

2IU8

33.4%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90716
(show subtarget assignments)

8

soluble

No

Cj0576

15791936

lpxD

UDP-3-O-[3-hydroxymyristoyl] glucosamine...

321

Predicted Essential

Community Requests

2IU8

35.5%

Campylobacter jejuni

IDP04398
(show subtarget assignments)

1

cloned

No

YPO1376

218928524

ftsK

putative cell division protein [Yersinia...

1305

drug target; putative drug target function;

Phase 4: April 2009

2IUS

33.3%

Yersinia pestis

Cellular processes

Cell division

IDP91892
(show subtarget assignments)

8

selected

No

SpneCM_010100009040

298255720

DNA translocase ftsk [Streptococcus pneu...

741

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2IUT

33.5%

Streptococcus pneumoniae

IDP02312
(show subtarget assignments)

1

expressed

No

GBAA2190

47778017

FtsK/SpoIIIE family protein [Bacillus an...

1342

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2IUT

7.4%

Bacillus anthracis

Cellular processes

Cell division

IDP01065
(show subtarget assignments)

1

expressed

No

STM3722

16767007

rfaG

glucosyltransferase I

374

Drug Target Function

Phase 2: March 2008

2IV7

86.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01952
(show subtarget assignments)

1

cloned

No

Cj1432c

15792750

putative sugar transferase [Campylobacte...

1031

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2IV7

7.7%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90847
(show subtarget assignments)

8

selected

No

S4100

30065095

waaG

LPS alpha1,3-glucosyltransferase [Shigel...

374

Predicted Essential

Community Requests

2IV7

89.8%

Shigella flexneri

IDP01784
(show subtarget assignments)

1

expressed

No

STM1383

16764733

ttrA

tetrathionate reductase complex subunit ...

1020

Conserved; Drug target functions

Phase 3: June 2008

2IVF

18.1%

Salmonella enterica

Energy metabolism

Electron transport

IDP02021
(show subtarget assignments)

1

cloned

No

CBU_1240

29541810

gcp

O-sialoglycoprotein endopeptidase [Coxie...

339

Conserved; Drug target functions

Phase 3: June 2008

2IVN

36%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00448
(show subtarget assignments)

1

purified

No

YPO0646

16120971

gcp

O-sialoglycoprotein endopeptidase

337

Drug Target Function

Phase 2: March 2008

2IVN

35.6%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01702
(show subtarget assignments)

1

soluble

No

GBAA0261

47525520

gcP

O-sialoglycoprotein endopeptidase [Bacil...

338

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2IVN

35.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02747
(show subtarget assignments)

1

soluble

No

FTT0147

56707317

gcp

O-sialoglycoprotein endopeptidase [Franc...

336

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2IVN

35.1%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00687
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2038

57284907

O-sialoglycoprotein endopeptidase

341

Drug Target Function

Phase 2: March 2008

2IVN

30.2%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01470
(show subtarget assignments)

1

purified

No

VC2608

15642603

ABC transporter, ATP-binding protein

664

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

23.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP00727
(show subtarget assignments)

1

cloned

No

SACOL2036

57284905

ABC transporter, ATP-binding protein

642

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

24.1%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP00708
(show subtarget assignments)

1

expressed

No

SACOL0779

57285742

ABC transporter, ATP-binding protein

625

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

22.2%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP02426
(show subtarget assignments)

1

cloned

No

CBU_1952

29542507

ABC transporter, ATP-binding protein [Co...

532

Conserved; Drug target functions

Phase 3: June 2008

2IW3

26.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP91022
(show subtarget assignments)

8

cloned

No

y2966

22126843

ompC

outer membrane porin protein C [Yersinia...

374

drug resistance / outer membrane porin

Community Requests

2IXX

67.9%

Yersinia pestis

IDP01208
(show subtarget assignments)

1

expressed

No

BA_2638

30257255

glycosyl transferase, putative

387

Essential Gene

Phase 2: March 2008

2IYA

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00552
(show subtarget assignments)

1

soluble

No

YPO0282

16120621

hmuS

hemin transport protein

345

Conserved Gene / Pathway

Phase 2: March 2008

2J0R

89.6%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP01080
(show subtarget assignments)

0

work_stopped

No

STM4220

16767470

lysC

aspartate kinase III

449

Conserved Gene / Pathway

Phase 2: March 2008

2J0W

93.1%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP05526
(show subtarget assignments)

1

soluble

No

CD1319

126698918

putative polysaccharide deacetylase [Clo...

247

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2J13

27.1%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP04266
(show subtarget assignments)

1

cloned

No

CPF_2122

110798774

pdaA

delta-lactam-biosynthetic de-N-acetylase...

265

conserved gene; putative drug target function;

Phase 4: April 2009

2J13

41.5%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP05732
(show subtarget assignments)

1

cloned

No

CD1205

126698801

ispA

geranyltranstransferase [Clostridium dif...

295

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2J1P

45.8%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone

IDP01148
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1159

30254878

katB

catalase

488

Conserved Gene / Pathway

Phase 2: March 2008

2J2M

64.8%

Bacillus anthracis

Cellular processes

Detoxification

IDP05133
(show subtarget assignments)

1

cloned

No

CD0264

126697836

flhF

flagellar biosynthesis regulator FlhF [C...

338

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2J37

26%

Clostridium difficile

Protein fate: Protein and peptide secretion and trafficking

IDP90551
(show subtarget assignments)

8

diffraction

No

VC0875

15640891

prolyl-tRNA synthetase [Vibrio cholerae ...

571

Predicted Essential

Community Requests

2J3L

45.5%

Vibrio cholerae

IDP90927
(show subtarget assignments)

8

in_crystallization_trials

No

YPO1068

16121369

proS

prolyl-tRNA synthetase [Yersinia pestis ...

572

Predicted Essential

Community Requests

2J3L

47.2%

Yersinia pestis

IDP04603
(show subtarget assignments)

1

in_crystallization_trials

No

BAS3670

49186669

prolyl-tRNA synthetase [Bacillus anthrac...

566

Proposed to be essential proteins

Phase 4: April 2009

2J3L

58.1%

Bacillus anthracis

IDP05650
(show subtarget assignments)

1

soluble

No

Cj0543

6968007

proS

hypothetical protein Cj0539 [Campylobact...

569

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2J3L

42.8%

Campylobacter jejuni

Protein synthesis: tRNA aminoacylation

IDP90581
(show subtarget assignments)

8

soluble

No

Cj0543

15791904

proS

prolyl-tRNA synthetase [Campylobacter je...

569

Predicted Essential

Community Requests

2J3L

42.8%

Campylobacter jejuni

IDP05230
(show subtarget assignments)

1

soluble

No

lmo1319

16803359

proS

prolyl-tRNA synthetase [Listeria monocyt...

568

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2J3L

63%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05337
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1282

57651833

proS

prolyl-tRNA synthetase [Staphylococcus a...

567

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2J3L

55.7%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP91709
(show subtarget assignments)

8

selected

No

NP_006107

5174703

TAB1

TGF-beta-activated kinase 1 and MAP3K7-b...

504

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2J4O

79.6%

Homo sapiens

IDP91386
(show subtarget assignments)

8

cloned

No

VV1_1450

27364835

cell shape-determining protein [Vibrio v...

296

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2J5U

19.3%

Vibrio vulnificus

IDP00802
(show subtarget assignments)

1

cloned

No

SACOL1704

57284716

mreC

rod shape-determining protein MreC

280

Conserved Gene / Pathway

Phase 2: March 2008

2J5U

29.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05624
(show subtarget assignments)

1

expressed

No

CD1146

126698741

mreC

putative rod shape-determining protein [...

297

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2J5U

25.3%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00274
(show subtarget assignments)

1

selected

No

AF180817_2494-3392

7329982

N/A

NS5 methyl transferase and RNA polymeras...

830

RNA-dependent RNA polymerase

Phase 3: June 2008

2J7U

55.5%

Dengue virus

Transcription

N/A

IDP00268
(show subtarget assignments)

1

cloned

No

AAX48017_2488-3387

61652905

N/A

NS5 methyl transferase and RNA polymeras...

900

RNA-dependent RNA polymerase

Phase 3: June 2008

2J7U

54.7%

Dengue virus

Transcription

N/A

IDP91056
(show subtarget assignments)

8

expressed

No

AAA42941

323448

viral polyprotein [Dengue virus 2]

3391

potential drug target / A structure of the co-complex between Dengue 2 strain 16681 full length NS3 and ...

Community Requests

2J7U

15.1%

Dengue virus

IDP04498
(show subtarget assignments)

1

purified

No

VC0791

15640810

sensor kinase citA [Vibrio cholerae O1 b...

565

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2J80

9.7%

Vibrio cholerae

Regulatory functions

Other

IDP91553
(show subtarget assignments)

8

expressed

No

BAB38471

13364525

ECs5048

hypothetical protein [Escherichia coli O...

430

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2J8K

10.5%

Escherichia coli

IDP90218
(show subtarget assignments)

8

soluble

No

MYXV_gp151

9633783

m148R

675

ankyrin motif, similar to VACV-Cop:B4R

Community Requests

2J8S

6.1%

Myxoma virus

host range factor

0

IDP04255
(show subtarget assignments)

1

cloned

No

CPF_1922

110799469

purB

adenylosuccinate lyase [Clostridium perf...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2J91

56.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02345
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1220

56708282

5-formyltetrahydroformate cycloligase fa...

182

Drug Target

Phase 3: June 2008

2JCB

28.6%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP01241
(show subtarget assignments)

1

expressed

No

BA_1474

30255405

penicillin-binding protein

673

Drug Target Function

Phase 2: March 2008

2JCH

28.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91663
(show subtarget assignments)

8

selected

No

NP_005550

38788416

LAMA1

laminin subunit alpha-1 precursor [Homo ...

3075

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2JD4

9.4%

Homo sapiens

IDP01129
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5296

30259774

ferritin

168

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

48.2%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00611
(show subtarget assignments)

1

crystallized

No

SACOL1952

57286299

ferritins family protein

166

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

39.2%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP01362
(show subtarget assignments)

1

purified

No

VC0158

15640188

glutamate racemase

265

Drug Target Function

Phase 2: March 2008

2JFN

49.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00597
(show subtarget assignments)

1

purified

No

YPO3909

16124041

murI

glutamate racemase

287

Conserved Gene / Pathway

Phase 2: March 2008

2JFN

71.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00328
(show subtarget assignments)

1

in_pdb
3UHP
3UHF
3UHO

No

Cj1652c

15792957

murI

glutamate racemase

250

Drug Target Function

Phase 2: March 2008

2JFX

53.7%

Campylobacter jejuni

Energy metabolism

Pentose phosphate pathway

IDP00567
(show subtarget assignments)

0

work_stopped

No

YPO1113

16121413

kgd

alpha-ketoglutarate decarboxylase

935

Virulence Associated Factor

Phase 2: March 2008

2JGD

87.8%

Yersinia pestis

Energy metabolism

TCA cycle

IDP04395
(show subtarget assignments)

1

cloned

No

FTT0076

56707255

sucA

2-oxoglutarate dehydrogenase E1 componen...

941

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2JGD

47.8%

Francisella tularensis

IDP90680
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1401c

15792719

tpiA

triosephosphate isomerase [Campylobacter...

223

Predicted Essential

Community Requests

2JGQ

48.2%

Campylobacter jejuni

IDP90938
(show subtarget assignments)

8

cloned

No

NMPDR 243277.1.peg.3917

218

Predicted Essential

Community Requests

2JGV

22.5%

Vibrio cholerae

IDP01064
(show subtarget assignments)

1

cloned

No

STM3719

16767004

rfaB

UDP-D-galactose:(glucosyl)lipopolysaccha...

359

Essential Gene

Phase 2: March 2008

2JJM

13.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02796
(show subtarget assignments)

1

cloned

No

Cj1127c

15792452

wlaE

general glycosylation pathway protein [C...

365

Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...

Phase 3: June 2008

2JJM

23.7%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00834
(show subtarget assignments)

1

expressed

No

SACOL2670

57286574

glycosyl transferase, group 1 family pro...

502

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

10.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00788
(show subtarget assignments)

1

crystallized

No

SACOL1043

57284414

glycosyl transferase, group 1 family pro...

493

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

16.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00776
(show subtarget assignments)

1

crystallized

No

SACOL0612

57285627

glycosyl transferase, group 1 family pro...

496

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

11.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00775
(show subtarget assignments)

1

purified

No

SACOL0611

57285626

glycosyl transferase, group 1 family pro...

490

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

14.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01239
(show subtarget assignments)

1

cloned

No

BA_5670

30260118

glycosyl transferase, group 1 family pro...

366

Drug Target Function

Phase 2: March 2008

2JJM

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01185
(show subtarget assignments)

1

cloned

No

BA_0280

30253775

glycosyl transferase, group 1 family pro...

443

Drug Target Function

Phase 2: March 2008

2JJM

13.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05194
(show subtarget assignments)

1

cloned

No

CD0843

126698423

putative glycosyl transferase [Clostridi...

411

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2JJM

19.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02634
(show subtarget assignments)

1

cloned

No

Cj1125c

15792450

wlaG

general glycosylation pathway protein [C...

376

Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...

Phase 3: June 2008

2JJM

22.6%

Campylobacter jejuni

Cellular processes

Chemotaxis and motility

IDP04455
(show subtarget assignments)

1

expressed

No

YPO1336

115347097

putative RNA methyltransferase [Yersinia...

376

conserved gene; putative drug target function;

Phase 4: April 2009

2JJQ

27.7%

Yersinia pestis

Amino acid biosynthesis

Serine family

IDP90189
(show subtarget assignments)

8

cloned

No

AAM13616.1

20153155

CPXV175 CDS

CPXV175 protein

277

CD47-like putative membrane protein

Community Requests

2JJS

13%

Cowpox virus

host defense modulator

0

IDP90133
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_159

68449233

CD47-like putative membrane protein [Mon...

277

similar to VACV-COP-A38L, MPXV-ZAI96-A40L

Community Requests

2JJS

11.6%

Monkeypox virus