Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02261 (show subtarget assignments)	1	expressed	No	GBAA2516	47527804	fba-1	fructose-bisphosphate aldolase [Bacillus...	281	Essential; Drug target functions	Phase 3: June 2008	1RV8	41.2%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP92026 (show subtarget assignments)	8	selected	No	TGME49_016450	237843315		proteasome subunit alpha type 3, putativ...	260	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3UNB	41.2%	Toxoplasma gondii

IDP05529 (show subtarget assignments)	1	cloned	No	CD2658	126700272	mraW	S-adenosyl-methyltransferase [Clostridiu...	318	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1WG8	41.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91077 (show subtarget assignments)	8	cloned	No	FTT_0109	56707283	msbA	Lipid A transport protein, ABC transport...	609	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5W	41.2%	Francisella tularensis

IDP92098 (show subtarget assignments)	8	selected	No	TGME49_090670	211966125		cytosol aminopeptidase [Toxoplasma gondi...	563	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3KQX	41.2%	Toxoplasma gondii

IDP91251 (show subtarget assignments)	8	expressed	No	NT01LM1754	16411067	trpD	trpD [Listeria monocytogenes]	339	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VQU	41.2%	Listeria monocytogenes	Amino acid biosynthesis: Aromatic amino acid family

IDP00835 (show subtarget assignments)	1	purified	No	SACOL2685	57286588	cap1C	capsular polysaccharide biosynthesis pro...	255	Conserved Gene / Pathway	Phase 2: March 2008	3QY6	41.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00813 (show subtarget assignments)	1	expressed	No	SACOL2004	57284879		leukocidin subunit precursor, putative	290	Conserved Gene / Pathway	Phase 2: March 2008	1LKF	41.2%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00041 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2409	30257040		chloramphenicol acetyltransferase	216	Virulence	Phase 1: October 2007	1QCA	41.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP91990 (show subtarget assignments)	8	selected	No	SpneCM_010100004332	298254829		ABC transporter substrate-binding protei...	80	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1XT8	41.2%	Streptococcus pneumoniae

IDP01202 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2079	30256728	dal-2	alanine racemase	391	Drug Target Function	Phase 2: March 2008	3E5P	41.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91617 (show subtarget assignments)	8	purified	No	BAB36908	13362956	ECs3485	chaperone-like protein [Escherichia coli...	196	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LW8	41.3%	Escherichia coli

IDP02026 (show subtarget assignments)	1	crystallized	No	CBU_0123	29540743	murE	UDP-N-acetylmuramoylalanyl-D-glutamate-2...	489	Conserved; Drug target functions	Phase 3: June 2008	1E8C	41.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00521 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3180	16123342	thiL	thiamine monophosphate kinase	329	Conserved Gene / Pathway	Phase 2: March 2008	3MCQ	41.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP90627 (show subtarget assignments)	8	selected	No	VC1239	15641252	cobU	adenosylcobinamide kinase/adenosylcobina...	179	Predicted Essential	Community Requests	1C9K	41.3%	Vibrio cholerae

IDP92084 (show subtarget assignments)	8	selected	No	TGME49_112250	237830299		DNA-directed RNA polymerase III subunit,...	106	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3QT1	41.3%	Toxoplasma gondii

IDP00695 (show subtarget assignments)	1	purified	No	SACOL2322	57285057		peptidase, M20/M25/M40 family	373	Drug Target Function	Phase 2: March 2008	1YSJ	41.3%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00681 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1756	57286191	pepQ	proline dipeptidase	351	Drug Target Function	Phase 2: March 2008	1WY2	41.3%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00324 (show subtarget assignments)	1	cloned	No	Cj1366c	15792689	glmS	D-fructose-6-phosphate amidotransferase ...	598	Drug Target Function	Phase 2: March 2008	1JXA	41.3%	Campylobacter jejuni	Unclassified	Unclassified

IDP02231 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1377	16803417	lisR	two-component response regulator [Lister...	226	Known virulence-Regulation; Predicted virulence-Resistance to antibiotics and to...	Phase 3: June 2008	1KGS	41.4%	Listeria monocytogenes	Regulatory functions	Other

IDP00548 (show subtarget assignments)	1	cloned	No	YPO0549	16120877	ftsI	penicillin-binding protein 3	587	Drug Target Function	Phase 2: March 2008	3OC2	41.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01014 (show subtarget assignments)	1	in_crystallization_trials	No	STM2780	16766091	pipB2	secreted effector protein	350	Virulence Associated Factor	Phase 2: March 2008	2LEZ	41.4%	Salmonella enterica	Unknown function	General

IDP02058 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0075	16120426	cpxP	periplasmic stress adaptor protein CpxP ...	162	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3ITF	41.4%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00693 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2145	57286359	glmS	D-fructose-6-phosphate amidotransferase ...	601	Drug Target Function	Phase 2: March 2008	1JXA	41.4%	Staphylococcus aureus	Central intermediary metabolism	Amino sugars

IDP05202 (show subtarget assignments)	1	cloned	No	CD1700	126699306	ribD	riboflavin biosynthesis protein [Clostri...	367	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2HXV	41.4%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91714 (show subtarget assignments)	8	selected	No	NP_006734	5803137	RBM3	putative RNA-binding protein 3 [Homo sap...	157	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1X5S	41.4%	Homo sapiens

IDP91799 (show subtarget assignments)	8	selected	No	AAL27442	16612079	vanE	VanE [Enterococcus faecalis]	352	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1E4E	41.5%	Enterococcus faecalis

IDP05736 (show subtarget assignments)	1	soluble	No	CD1702A	126699309	thiS	putative thiamine biosynthesis protein [...	64	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1TYG	41.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP00841 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0876	57284336		arsenate reductase, putative	118	Conserved Gene / Pathway	Phase 2: March 2008	3FZ4	41.5%	Staphylococcus aureus	Cellular processes	Detoxification

IDP04266 (show subtarget assignments)	1	cloned	No	CPF_2122	110798774	pdaA	delta-lactam-biosynthetic de-N-acetylase...	265	conserved gene; putative drug target function;	Phase 4: April 2009	2J13	41.5%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP02579 (show subtarget assignments)	1	cloned	No	Cj1131c	15792456	galE	UDP-glucose 4-epimerase [Campylobacter j...	328	Predicted virulence-Posttranslational modification	Phase 3: June 2008	2C20	41.5%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02726 (show subtarget assignments)	1	cloned	No	GBAA4229	47529522		maltosaccharide ABC transporter, maltosa...	419	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZYK	41.5%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02184 (show subtarget assignments)	1	expressed	No	CBU_1352	29541917	ftsH	ATP-dependent metalloprotease FtsH [Coxi...	647	Conserved; Drug target functions	Phase 3: June 2008	2CE7	41.6%	Coxiella burnetii	Cellular processes	Cell division

IDP04652 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1432c	56708477	ppnK	inorganic phosphate/ATP-NAD kinase [Fran...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2AN1	41.6%	Francisella tularensis

IDP01795 (show subtarget assignments)	1	expressed	No	GBAA0792	47526077	celA-1	PTS system, cellobiose-specific IIB comp...	101	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41.6%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04276 (show subtarget assignments)	1	soluble	No	FTT0312c	56707465	folA	dihydrofolate reductase type I [Francise...	166	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3JW3	41.6%	Francisella tularensis

IDP01457 (show subtarget assignments)	1	cloned	No	VC2407	15642404		penicillin-binding protein 3	580	Drug Target Function	Phase 2: March 2008	3OC2	41.6%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02519 (show subtarget assignments)	1	cloned	No	GBAA1494	47526768	resA	thiol-disulfide oxidoreductase [Bacillus...	173	Conserved; Drug target functions	Phase 3: June 2008	1ST9	41.6%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02373 (show subtarget assignments)	1	expressed	No	FTT0438	56707582	mpl	UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...	456	Conserved; Drug target functions	Phase 3: June 2008	3HN7	41.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05008 (show subtarget assignments)	1	cloned	No	CD1777	126699386		putative arsenate reductase [Clostridium...	120	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3FZ4	41.7%	Clostridium difficile	Cellular processes: Detoxification

IDP02773 (show subtarget assignments)	1	crystallized	No	FTT1389	56708438	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	264	Conserved; Drug target functions	Phase 3: June 2008	1O66	41.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP90872 (show subtarget assignments)	8	expressed	No	Cj1096c	15792421	metK	S-adenosylmethionine synthetase [Campylo...	398	Predicted Essential	Community Requests	3IML	41.7%	Campylobacter jejuni

IDP02745 (show subtarget assignments)	1	cloned	No	GBAA4384	47529679	bfmbAa	3-methyl-2-oxobutanoate dehydrogenase, a...	333	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1UM9	41.7%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP91891 (show subtarget assignments)	8	selected	No	SpneCM_010100007700	298255470		putative glutamine-binding protein precu...	254	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2V25	41.7%	Streptococcus pneumoniae

IDP01369 (show subtarget assignments)	1	in_crystallization_trials	No	VC0244	15640274		perosamine synthase	367	Conserved Gene / Pathway	Phase 2: March 2008	3BN1	41.7%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01336 (show subtarget assignments)	1	purified	No	VC1428	15641439	potA	putrescine/spermidine ABC transporter AT...	377	Conserved Gene / Pathway	Phase 2: March 2008	2D62	41.7%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP05576 (show subtarget assignments)	1	cloned	No	BA_0536	30254062	bcP	bacterioferritin comigratory protein [Ba...	151	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3DRN	41.7%	Bacillus anthracis	Cellular processes: Detoxification

IDP02326 (show subtarget assignments)	1	purified	No	FTT0976	56708068	trxA2	thioredoxin [Francisella tularensis subs...	108	Drug Target	Phase 3: June 2008	1SYR	41.7%	Francisella tularensis	Energy metabolism	Electron transport

IDP02243 (show subtarget assignments)	1	cloned	No	YPO0834	16121142	manX	putative PTS transport protein [Yersinia...	165	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3EYE	41.8%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01677 (show subtarget assignments)	1	soluble	No	GBAA0159	47525416	glmS	D-fructose-6-phosphate amidotransferase ...	600	Drug target motif; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JXA	41.8%	Bacillus anthracis	Central intermediary metabolism	Amino sugars

IDP02479 (show subtarget assignments)	1	cloned	No	lmo1287	16803327	parC	DNA topoisomerase IV subunit A [Listeria...	819	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	2INR	41.8%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP90985 (show subtarget assignments)	8	expressed	No	y0964	22124871		hypothetical protein y0964 [Yersinia pes...	421	other biological interest / -	Community Requests	3MVE	41.8%	Yersinia pestis

IDP00026 (show subtarget assignments)	1	soluble	No	BA_0399	30253934		tellurium resistance protein, putative	198	Virulence	Phase 1: October 2007	3IBZ	41.9%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP04510 (show subtarget assignments)	1	cloned	No	CPF_2272	110798867	era	GTP-binding protein Era [Clostridium per...	296	conserved gene; putative drug target function;	Phase 4: April 2009	3IEV	41.9%	Clostridium perfringens	Cellular processes	Cell division

IDP05322 (show subtarget assignments)	1	cloned	No	CD3430	126701053	cbiC	cobalt-precorrin-8X methylmutase [Clostr...	210	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2AFR	41.9%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP00865 (show subtarget assignments)	1	expressed	No	STM3570	16766856	ftsE	cell division protein FtsE	222	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	41.9%	Salmonella enterica	Cellular processes	Cell division

IDP05339 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1622	57651958	glyS	glycyl-tRNA synthetase [Staphylococcus a...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ATI	41.9%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP92085 (show subtarget assignments)	8	selected	No	TGME49_116190	237830977		superoxide dismutase, putative [Toxoplas...	258	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2BPI	41.9%	Toxoplasma gondii

IDP02437 (show subtarget assignments)	1	expressed	No	FTT1226c	56708288	iscS	cysteine desulfarase [Francisella tulare...	391	Drug Target	Phase 3: June 2008	1P3W	41.9%	Francisella tularensis	Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers	Pyruvate familyOther

IDP02656 (show subtarget assignments)	1	expressed	No	FTT0558	56707688		short chain dehydrogenase [Francisella t...	203	Drug Target	Phase 3: June 2008	3D7L	41.9%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP90278 (show subtarget assignments)	8	crystallized	No	TGME49_003450	211965291		hypothetical protein, conserved [Toxopla...	227	Unpublished data from signature-tagged mutagenesis (STM) has identified this nov...	Community Requests	2PD0	41.9%	Toxoplasma gondii

IDP90166 (show subtarget assignments)	8	soluble	No	CD1837	126699446	aroE	shikimate dehydrogenase [Clostridium dif...	269	Potential drug target. Shikimate pathway enzyme	Community Requests	3FBT	42%	Clostridium difficile

IDP01818 (show subtarget assignments)	1	soluble	No	GBAA5444	47530758	celA-2	PTS system, cellobiose-specific IIB comp...	100	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	42%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02720 (show subtarget assignments)	1	cloned	No	GBAA3950	47529240	infB	translation initiation factor IF-2 [Baci...	686	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1ZO1	42%	Bacillus anthracis	Protein synthesis	Translation factors

IDP90149 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_195.5	68449268		serine protease inhibitor-like SPI-1 pro...	357	similar to part of VACV-COP-C12L, MPXV-ZAI96-B19R	Community Requests	1F0C	42%	Monkeypox virus

IDP04571 (show subtarget assignments)	1	cloned	No	BAS0002	49183041		DNA polymerase III subunit beta [Bacillu...	379	Proposed to be essential proteins	Phase 4: April 2009	2AWA	42%	Bacillus anthracis

IDP01218 (show subtarget assignments)	1	expressed	No	BA_3712	73919984		Histidine ammonia-lyase (Histidase)	505	Drug Target Function	Phase 2: March 2008	1GK2	42%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP04532 (show subtarget assignments)	1	cloned	No	STM3301_1_390	16766597	obgE	GTPase ObgE [Salmonella typhimurium LT2]...	390	Salmonella essential protein	Phase 4: April 2009	1LNZ	42.1%	Salmonella enterica

IDP91640 (show subtarget assignments)	8	cloned	No	NP_216900	15609521		bifunctional salicyl-AMP ligase/salicyl-...	565	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	1MD9	42.1%	Mycobacterium tuberculosis

IDP91053 (show subtarget assignments)	8	in_crystallization_trials	No	ENC0002	0			247	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3B89	42.1%	Enterobacter cloacae

IDP01778 (show subtarget assignments)	1	cloned	No	YPO3689	16123828		putative ribonuclease [Yersinia pestis C...	152	Conserved; CD; Drug target functions	Phase 3: June 2008	1BNE	42.1%	Yersinia pestis	Transcription	Degradation of RNA

IDP01659 (show subtarget assignments)	1	crystallized	No	CBU_1739	29542296		tetrapyrrole (Corrin/Porphyrin) methylas...	285	Conserved; Drug target functions	Phase 3: June 2008	3KWP	42.1%	Coxiella burnetii	Unknown function	General

IDP05740 (show subtarget assignments)	1	cloned	No	CD2372	126699987	nadA	quinolinate synthetase [Clostridium diff...	304	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2QS0	42.1%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP01436 (show subtarget assignments)	1	crystallized	No	VC1976	15641978		menaquinone-specific isochorismate synth...	435	Drug Target Function	Phase 2: March 2008	3GSE	42.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP90580 (show subtarget assignments)	8	cloned	No	Cj1091c	15792416	leuS	leucyl-tRNA synthetase [Campylobacter je...	809	Predicted Essential	Community Requests	1H3N	42.1%	Campylobacter jejuni

IDP01228 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4283	30258785		peptidyl-prolyl cis-trans isomerase, cyc...	145	Conserved Gene / Pathway	Phase 2: March 2008	1AK4	42.1%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP05562 (show subtarget assignments)	1	cloned	No	lmo2172	16804211	-	hypothetical protein lmo2172 [Listeria m...	527	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2AHU	42.1%	Listeria monocytogenes	Energy metabolism: Fermentation

IDP02250 (show subtarget assignments)	1	soluble	No	YPO0278	16120617	metC	cystathionine beta-lyase [Yersinia pesti...	393	Involved in virulence; Drug target functions	Phase 3: June 2008	1CL2	42.2%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP00054 (show subtarget assignments)	1	crystallized	No	BA_3600	30258128		acetyltransferase, CYSE/LACA/LPXA/NODL f...	185	Virulence	Phase 1: October 2007	1KHR	42.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP04600 (show subtarget assignments)	1	cloned	No	BAS2547	49185555		preprotein translocase subunit SecY [Bac...	434	Proposed to be essential proteins	Phase 4: April 2009	3DIN	42.2%	Bacillus anthracis

IDP04021 (show subtarget assignments)	1	expressed	No	BAS3695	49186694		30S ribosomal protein S16 [Bacillus anth...	90	Proposed to be essential proteins	Phase 4: April 2009	1EMW	42.2%	Bacillus anthracis

IDP05281 (show subtarget assignments)	1	in_crystallization_trials	No	CD0136	126697708		PTS system, IIB component [Clostridium d...	108	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1H9C	42.2%	Clostridium difficile	Signal transduction: PTS

IDP05099 (show subtarget assignments)	1	cloned	No	CD0754	126698334	thiI	thiamine biosynthesis protein ThiI [Clos...	391	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2C5S	42.2%	Clostridium difficile	Protein synthesis: tRNA and rRNA base modification

IDP90764 (show subtarget assignments)	8	purified	No	STM0046	16763436	ileS	isoleucyl-tRNA synthetase [Salmonella ty...	944	Predicted Essential	Community Requests	1FFY	42.2%	Salmonella enterica

IDP02299 (show subtarget assignments)	1	cloned	No	FTT0034	56707214	nuoD	NADH dehydrogenase subunit D [Francisell...	417	Drug Target	Phase 3: June 2008	2FUG	42.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP90631 (show subtarget assignments)	8	expressed	No	YPO2526	16122745		acyl-CoA thioester hydrolase YfbB [Yersi...	272	Predicted Essential	Community Requests	1R3D	42.3%	Yersinia pestis

IDP90869 (show subtarget assignments)	8	cloned	No	Cj1250	15792574	purD	phosphoribosylamine--glycine ligase [Cam...	416	Predicted Essential	Community Requests	1VKZ	42.3%	Campylobacter jejuni

IDP01383 (show subtarget assignments)	1	in_crystallization_trials	No	VC0538	15640560		thiosulfate ABC transporter, periplasmic...	333	Conserved Gene / Pathway	Phase 2: March 2008	1SBP	42.3%	Vibrio cholerae	Transport and binding proteins	Anions

IDP04203 (show subtarget assignments)	1	selected	No	CPF_2298	110800865	gpr	germination protease [Clostridium perfri...	325	conserved gene; putative drug target function;	Phase 4: April 2009	1C8B	42.3%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP02541 (show subtarget assignments)	1	expressed	No	CBU_1709	29542267	dapB	dihydrodipicolinate reductase [Coxiella ...	239	Conserved; Drug target functions	Phase 3: June 2008	1YL5	42.3%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP91078 (show subtarget assignments)	8	cloned	No	CBU_0856	29541449		ABC transporter, ATP-binding/permease pr...	596	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5X	42.3%	Coxiella burnetii

IDP00425 (show subtarget assignments)	1	purified	No	YPO3863	16123998	wecC	UDP-N-acetyl-D-mannosamine dehydrogenase...	420	Conserved Gene / Pathway	Phase 2: March 2008	3OJL	42.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP92082 (show subtarget assignments)	8	selected	No	TGME49_107570	237845455		glycerol-3-phosphate dehydrogenase, puta...	401	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1X0V	42.4%	Toxoplasma gondii

IDP04229 (show subtarget assignments)	1	purified	No	CPF_0676	110798651	purN	phosphoribosylglycinamide formyltransfer...	204	conserved gene; putative drug target function;	Phase 4: April 2009	2YWR	42.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90799 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3577	16123721		D-arabinose 5-phosphate isomerase [Yersi...	328	Predicted Essential	Community Requests	2XHZ	42.4%	Yersinia pestis

IDP02171 (show subtarget assignments)	1	soluble	No	CBU_0894	29541483	folC	FolC bifunctional protein [Coxiella burn...	416	Conserved; Drug target functions	Phase 3: June 2008	1W78	42.5%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02089 (show subtarget assignments)	1	cloned	No	CBU_0424	29541033	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	266	Conserved; Drug target functions	Phase 3: June 2008	1OY0	42.5%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00921 (show subtarget assignments)	1	purified	No	STM0507	16763887	ybbA	putative ABC transporter ATP-binding pro...	228	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	42.5%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP92040 (show subtarget assignments)	8	selected	No	TGME49_039310	237834547		ribose 5-phosphate isomerase, putative [...	259	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2F8M	42.5%	Toxoplasma gondii

IDP91992 (show subtarget assignments)	8	purified	No	SpneCM_010100001714	298254315		sortase [Streptococcus pneumoniae str. C...	247	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3FN5	42.5%	Streptococcus pneumoniae

IDP02261
(show subtarget assignments)

1

expressed

No

GBAA2516

47527804

fba-1

fructose-bisphosphate aldolase [Bacillus...

281

Essential; Drug target functions

Phase 3: June 2008

1RV8

41.2%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP92026
(show subtarget assignments)

8

selected

No

TGME49_016450

237843315

proteasome subunit alpha type 3, putativ...

260

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3UNB

41.2%

Toxoplasma gondii

IDP05529
(show subtarget assignments)

1

cloned

No

CD2658

126700272

mraW

S-adenosyl-methyltransferase [Clostridiu...

318

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1WG8

41.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91077
(show subtarget assignments)

8

cloned

No

FTT_0109

56707283

msbA

Lipid A transport protein, ABC transport...

609

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5W

41.2%

Francisella tularensis

IDP92098
(show subtarget assignments)

8

selected

No

TGME49_090670

211966125

cytosol aminopeptidase [Toxoplasma gondi...

563

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3KQX

41.2%

Toxoplasma gondii

IDP91251
(show subtarget assignments)

8

expressed

No

NT01LM1754

16411067

trpD

trpD [Listeria monocytogenes]

339

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VQU

41.2%

Listeria monocytogenes

Amino acid biosynthesis: Aromatic amino acid family

IDP00835
(show subtarget assignments)

1

purified

No

SACOL2685

57286588

cap1C

capsular polysaccharide biosynthesis pro...

255

Conserved Gene / Pathway

Phase 2: March 2008

3QY6

41.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00813
(show subtarget assignments)

1

expressed

No

SACOL2004

57284879

leukocidin subunit precursor, putative

290

Conserved Gene / Pathway

Phase 2: March 2008

1LKF

41.2%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00041
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2409

30257040

chloramphenicol acetyltransferase

216

Virulence

Phase 1: October 2007

1QCA

41.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP91990
(show subtarget assignments)

8

selected

No

SpneCM_010100004332

298254829

ABC transporter substrate-binding protei...

80

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1XT8

41.2%

Streptococcus pneumoniae

IDP01202
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2079

30256728

dal-2

alanine racemase

391

Drug Target Function

Phase 2: March 2008

3E5P

41.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91617
(show subtarget assignments)

8

purified

No

BAB36908

13362956

ECs3485

chaperone-like protein [Escherichia coli...

196

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LW8

41.3%

Escherichia coli

IDP02026
(show subtarget assignments)

1

crystallized

No

CBU_0123

29540743

murE

UDP-N-acetylmuramoylalanyl-D-glutamate-2...

489

Conserved; Drug target functions

Phase 3: June 2008

1E8C

41.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00521
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3180

16123342

thiL

thiamine monophosphate kinase

329

Conserved Gene / Pathway

Phase 2: March 2008

3MCQ

41.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP90627
(show subtarget assignments)

8

selected

No

VC1239

15641252

cobU

adenosylcobinamide kinase/adenosylcobina...

179

Predicted Essential

Community Requests

1C9K

41.3%

Vibrio cholerae

IDP92084
(show subtarget assignments)

8

selected

No

TGME49_112250

237830299

DNA-directed RNA polymerase III subunit,...

106

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3QT1

41.3%

Toxoplasma gondii

IDP00695
(show subtarget assignments)

1

purified

No

SACOL2322

57285057

peptidase, M20/M25/M40 family

373

Drug Target Function

Phase 2: March 2008

1YSJ

41.3%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00681
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1756

57286191

pepQ

proline dipeptidase

351

Drug Target Function

Phase 2: March 2008

1WY2

41.3%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00324
(show subtarget assignments)

1

cloned

No

Cj1366c

15792689

glmS

D-fructose-6-phosphate amidotransferase ...

598

Drug Target Function

Phase 2: March 2008

1JXA

41.3%

Campylobacter jejuni

Unclassified

IDP02231
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1377

16803417

lisR

two-component response regulator [Lister...

226

Known virulence-Regulation; Predicted virulence-Resistance to antibiotics and to...

Phase 3: June 2008

1KGS

41.4%

Listeria monocytogenes

Regulatory functions

Other

IDP00548
(show subtarget assignments)

1

cloned

No

YPO0549

16120877

ftsI

penicillin-binding protein 3

587

Drug Target Function

Phase 2: March 2008

3OC2

41.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01014
(show subtarget assignments)

1

in_crystallization_trials

No

STM2780

16766091

pipB2

secreted effector protein

350

Virulence Associated Factor

Phase 2: March 2008

2LEZ

41.4%

Salmonella enterica

Unknown function

General

IDP02058
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0075

16120426

cpxP

periplasmic stress adaptor protein CpxP ...

162

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3ITF

41.4%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00693
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2145

57286359

glmS

D-fructose-6-phosphate amidotransferase ...

601

Drug Target Function

Phase 2: March 2008

1JXA

41.4%

Staphylococcus aureus

Central intermediary metabolism

Amino sugars

IDP05202
(show subtarget assignments)

1

cloned

No

CD1700

126699306

ribD

riboflavin biosynthesis protein [Clostri...

367

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2HXV

41.4%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91714
(show subtarget assignments)

8

selected

No

NP_006734

5803137

RBM3

putative RNA-binding protein 3 [Homo sap...

157

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1X5S

41.4%

Homo sapiens

IDP91799
(show subtarget assignments)

8

selected

No

AAL27442

16612079

vanE

VanE [Enterococcus faecalis]

352

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1E4E

41.5%

Enterococcus faecalis

IDP05736
(show subtarget assignments)

1

soluble

No

CD1702A

126699309

thiS

putative thiamine biosynthesis protein [...

64

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1TYG

41.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP00841
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0876

57284336

arsenate reductase, putative

118

Conserved Gene / Pathway

Phase 2: March 2008

3FZ4

41.5%

Staphylococcus aureus

Cellular processes

Detoxification

IDP04266
(show subtarget assignments)

1

cloned

No

CPF_2122

110798774

pdaA

delta-lactam-biosynthetic de-N-acetylase...

265

conserved gene; putative drug target function;

Phase 4: April 2009

2J13

41.5%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP02579
(show subtarget assignments)

1

cloned

No

Cj1131c

15792456

galE

UDP-glucose 4-epimerase [Campylobacter j...

328

Predicted virulence-Posttranslational modification

Phase 3: June 2008

2C20

41.5%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02726
(show subtarget assignments)

1

cloned

No

GBAA4229

47529522

maltosaccharide ABC transporter, maltosa...

419

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZYK

41.5%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02184
(show subtarget assignments)

1

expressed

No

CBU_1352

29541917

ftsH

ATP-dependent metalloprotease FtsH [Coxi...

647

Conserved; Drug target functions

Phase 3: June 2008

2CE7

41.6%

Coxiella burnetii

Cellular processes

Cell division

IDP04652
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1432c

56708477

ppnK

inorganic phosphate/ATP-NAD kinase [Fran...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2AN1

41.6%

Francisella tularensis

IDP01795
(show subtarget assignments)

1

expressed

No

GBAA0792

47526077

celA-1

PTS system, cellobiose-specific IIB comp...

101

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41.6%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04276
(show subtarget assignments)

1

soluble

No

FTT0312c

56707465

folA

dihydrofolate reductase type I [Francise...

166

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3JW3

41.6%

Francisella tularensis

IDP01457
(show subtarget assignments)

1

cloned

No

VC2407

15642404

penicillin-binding protein 3

580

Drug Target Function

Phase 2: March 2008

3OC2

41.6%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02519
(show subtarget assignments)

1

cloned

No

GBAA1494

47526768

resA

thiol-disulfide oxidoreductase [Bacillus...

173

Conserved; Drug target functions

Phase 3: June 2008

1ST9

41.6%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02373
(show subtarget assignments)

1

expressed

No

FTT0438

56707582

mpl

UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...

456

Conserved; Drug target functions

Phase 3: June 2008

3HN7

41.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05008
(show subtarget assignments)

1

cloned

No

CD1777

126699386

putative arsenate reductase [Clostridium...

120

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3FZ4

41.7%

Clostridium difficile

Cellular processes: Detoxification

IDP02773
(show subtarget assignments)

1

crystallized

No

FTT1389

56708438

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

264

Conserved; Drug target functions

Phase 3: June 2008

1O66

41.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP90872
(show subtarget assignments)

8

expressed

No

Cj1096c

15792421

metK

S-adenosylmethionine synthetase [Campylo...

398

Predicted Essential

Community Requests

3IML

41.7%

Campylobacter jejuni

IDP02745
(show subtarget assignments)

1

cloned

No

GBAA4384

47529679

bfmbAa

3-methyl-2-oxobutanoate dehydrogenase, a...

333

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1UM9

41.7%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP91891
(show subtarget assignments)

8

selected

No

SpneCM_010100007700

298255470

putative glutamine-binding protein precu...

254

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2V25

41.7%

Streptococcus pneumoniae

IDP01369
(show subtarget assignments)

1

in_crystallization_trials

No

VC0244

15640274

perosamine synthase

367

Conserved Gene / Pathway

Phase 2: March 2008

3BN1

41.7%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01336
(show subtarget assignments)

1

purified

No

VC1428

15641439

potA

putrescine/spermidine ABC transporter AT...

377

Conserved Gene / Pathway

Phase 2: March 2008

2D62

41.7%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP05576
(show subtarget assignments)

1

cloned

No

BA_0536

30254062

bcP

bacterioferritin comigratory protein [Ba...

151

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3DRN

41.7%

Bacillus anthracis

Cellular processes: Detoxification

IDP02326
(show subtarget assignments)

1

purified

No

FTT0976

56708068

trxA2

thioredoxin [Francisella tularensis subs...

108

Drug Target

Phase 3: June 2008

1SYR

41.7%

Francisella tularensis

Energy metabolism

Electron transport

IDP02243
(show subtarget assignments)

1

cloned

No

YPO0834

16121142

manX

putative PTS transport protein [Yersinia...

165

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3EYE

41.8%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01677
(show subtarget assignments)

1

soluble

No

GBAA0159

47525416

glmS

D-fructose-6-phosphate amidotransferase ...

600

Drug target motif; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JXA

41.8%

Bacillus anthracis

Central intermediary metabolism

Amino sugars

IDP02479
(show subtarget assignments)

1

cloned

No

lmo1287

16803327

parC

DNA topoisomerase IV subunit A [Listeria...

819

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

2INR

41.8%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP90985
(show subtarget assignments)

8

expressed

No

y0964

22124871

hypothetical protein y0964 [Yersinia pes...

421

other biological interest / -

Community Requests

3MVE

41.8%

Yersinia pestis

IDP00026
(show subtarget assignments)

1

soluble

No

BA_0399

30253934

tellurium resistance protein, putative

198

Virulence

Phase 1: October 2007

3IBZ

41.9%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP04510
(show subtarget assignments)

1

cloned

No

CPF_2272

110798867

era

GTP-binding protein Era [Clostridium per...

296

conserved gene; putative drug target function;

Phase 4: April 2009

3IEV

41.9%

Clostridium perfringens

Cellular processes

Cell division

IDP05322
(show subtarget assignments)

1

cloned

No

CD3430

126701053

cbiC

cobalt-precorrin-8X methylmutase [Clostr...

210

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2AFR

41.9%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP00865
(show subtarget assignments)

1

expressed

No

STM3570

16766856

ftsE

cell division protein FtsE

222

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

41.9%

Salmonella enterica

Cellular processes

Cell division

IDP05339
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1622

57651958

glyS

glycyl-tRNA synthetase [Staphylococcus a...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ATI

41.9%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP92085
(show subtarget assignments)

8

selected

No

TGME49_116190

237830977

superoxide dismutase, putative [Toxoplas...

258

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2BPI

41.9%

Toxoplasma gondii

IDP02437
(show subtarget assignments)

1

expressed

No

FTT1226c

56708288

iscS

cysteine desulfarase [Francisella tulare...

391

Drug Target

Phase 3: June 2008

1P3W

41.9%

Francisella tularensis

Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers

Pyruvate familyOther

IDP02656
(show subtarget assignments)

1

expressed

No

FTT0558

56707688

short chain dehydrogenase [Francisella t...

203

Drug Target

Phase 3: June 2008

3D7L

41.9%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP90278
(show subtarget assignments)

8

crystallized

No

TGME49_003450

211965291

hypothetical protein, conserved [Toxopla...

227

Unpublished data from signature-tagged mutagenesis (STM) has identified this nov...

Community Requests

2PD0

41.9%

Toxoplasma gondii

IDP90166
(show subtarget assignments)

8

soluble

No

CD1837

126699446

aroE

shikimate dehydrogenase [Clostridium dif...

269

Potential drug target. Shikimate pathway enzyme

Community Requests

3FBT

42%

Clostridium difficile

IDP01818
(show subtarget assignments)

1

soluble

No

GBAA5444

47530758

celA-2

PTS system, cellobiose-specific IIB comp...

100

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

42%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02720
(show subtarget assignments)

1

cloned

No

GBAA3950

47529240

infB

translation initiation factor IF-2 [Baci...

686

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1ZO1

42%

Bacillus anthracis

Protein synthesis

Translation factors

IDP90149
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_195.5

68449268

serine protease inhibitor-like SPI-1 pro...

357

Community Requests

1F0C

42%

Monkeypox virus

IDP04571
(show subtarget assignments)

1

cloned

No

BAS0002

49183041

DNA polymerase III subunit beta [Bacillu...

379

Proposed to be essential proteins

Phase 4: April 2009

2AWA

42%

Bacillus anthracis

IDP01218
(show subtarget assignments)

1

expressed

No

BA_3712

73919984

Histidine ammonia-lyase (Histidase)

505

Drug Target Function

Phase 2: March 2008

1GK2

42%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP04532
(show subtarget assignments)

1

cloned

No

STM3301_1_390

16766597

obgE

GTPase ObgE [Salmonella typhimurium LT2]...

390

Salmonella essential protein

Phase 4: April 2009

1LNZ

42.1%

Salmonella enterica

IDP91640
(show subtarget assignments)

8

cloned

No

NP_216900

15609521

bifunctional salicyl-AMP ligase/salicyl-...

565

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

1MD9

42.1%

Mycobacterium tuberculosis

IDP91053
(show subtarget assignments)

8

in_crystallization_trials

No

ENC0002

0

247

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3B89

42.1%

Enterobacter cloacae

IDP01778
(show subtarget assignments)

1

cloned

No

YPO3689

16123828

putative ribonuclease [Yersinia pestis C...

152

Conserved; CD; Drug target functions

Phase 3: June 2008

1BNE

42.1%

Yersinia pestis

Transcription

Degradation of RNA

IDP01659
(show subtarget assignments)

1

crystallized

No

CBU_1739

29542296

tetrapyrrole (Corrin/Porphyrin) methylas...

285

Conserved; Drug target functions

Phase 3: June 2008

3KWP

42.1%

Coxiella burnetii

Unknown function

General

IDP05740
(show subtarget assignments)

1

cloned

No

CD2372

126699987

nadA

quinolinate synthetase [Clostridium diff...

304

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2QS0

42.1%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP01436
(show subtarget assignments)

1

crystallized

No

VC1976

15641978

menaquinone-specific isochorismate synth...

435

Drug Target Function

Phase 2: March 2008

3GSE

42.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP90580
(show subtarget assignments)

8

cloned

No

Cj1091c

15792416

leuS

leucyl-tRNA synthetase [Campylobacter je...

809

Predicted Essential

Community Requests

1H3N

42.1%

Campylobacter jejuni

IDP01228
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4283

30258785

peptidyl-prolyl cis-trans isomerase, cyc...

145

Conserved Gene / Pathway

Phase 2: March 2008

1AK4

42.1%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP05562
(show subtarget assignments)

1

cloned

No

lmo2172

16804211

-

hypothetical protein lmo2172 [Listeria m...

527

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2AHU

42.1%

Listeria monocytogenes

Energy metabolism: Fermentation

IDP02250
(show subtarget assignments)

1

soluble

No

YPO0278

16120617

metC

cystathionine beta-lyase [Yersinia pesti...

393

Involved in virulence; Drug target functions

Phase 3: June 2008

1CL2

42.2%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP00054
(show subtarget assignments)

1

crystallized

No

BA_3600

30258128

acetyltransferase, CYSE/LACA/LPXA/NODL f...

185

Virulence

Phase 1: October 2007

1KHR

42.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP04600
(show subtarget assignments)

1

cloned

No

BAS2547

49185555

preprotein translocase subunit SecY [Bac...

434

Proposed to be essential proteins

Phase 4: April 2009

3DIN

42.2%

Bacillus anthracis

IDP04021
(show subtarget assignments)

1

expressed

No

BAS3695

49186694

30S ribosomal protein S16 [Bacillus anth...

90

Proposed to be essential proteins

Phase 4: April 2009

1EMW

42.2%

Bacillus anthracis

IDP05281
(show subtarget assignments)

1

in_crystallization_trials

No

CD0136

126697708

PTS system, IIB component [Clostridium d...

108

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1H9C

42.2%

Clostridium difficile

Signal transduction: PTS

IDP05099
(show subtarget assignments)

1

cloned

No

CD0754

126698334

thiI

thiamine biosynthesis protein ThiI [Clos...

391

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2C5S

42.2%

Clostridium difficile

Protein synthesis: tRNA and rRNA base modification

IDP90764
(show subtarget assignments)

8

purified

No

STM0046

16763436

ileS

isoleucyl-tRNA synthetase [Salmonella ty...

944

Predicted Essential

Community Requests

1FFY

42.2%

Salmonella enterica

IDP02299
(show subtarget assignments)

1

cloned

No

FTT0034

56707214

nuoD

NADH dehydrogenase subunit D [Francisell...

417

Drug Target

Phase 3: June 2008

2FUG

42.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP90631
(show subtarget assignments)

8

expressed

No

YPO2526

16122745

acyl-CoA thioester hydrolase YfbB [Yersi...

272

Predicted Essential

Community Requests

1R3D

42.3%

Yersinia pestis

IDP90869
(show subtarget assignments)

8

cloned

No

Cj1250

15792574

purD

phosphoribosylamine--glycine ligase [Cam...

416

Predicted Essential

Community Requests

1VKZ

42.3%

Campylobacter jejuni

IDP01383
(show subtarget assignments)

1

in_crystallization_trials

No

VC0538

15640560

thiosulfate ABC transporter, periplasmic...

333

Conserved Gene / Pathway

Phase 2: March 2008

1SBP

42.3%

Vibrio cholerae

Transport and binding proteins

Anions

IDP04203
(show subtarget assignments)

1

selected

No

CPF_2298

110800865

gpr

germination protease [Clostridium perfri...

325

conserved gene; putative drug target function;

Phase 4: April 2009

1C8B

42.3%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP02541
(show subtarget assignments)

1

expressed

No

CBU_1709

29542267

dapB

dihydrodipicolinate reductase [Coxiella ...

239

Conserved; Drug target functions

Phase 3: June 2008

1YL5

42.3%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP91078
(show subtarget assignments)

8

cloned

No

CBU_0856

29541449

ABC transporter, ATP-binding/permease pr...

596

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5X

42.3%

Coxiella burnetii

IDP00425
(show subtarget assignments)

1

purified

No

YPO3863

16123998

wecC

UDP-N-acetyl-D-mannosamine dehydrogenase...

420

Conserved Gene / Pathway

Phase 2: March 2008

3OJL

42.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP92082
(show subtarget assignments)

8

selected

No

TGME49_107570

237845455

glycerol-3-phosphate dehydrogenase, puta...

401

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1X0V

42.4%

Toxoplasma gondii

IDP04229
(show subtarget assignments)

1

purified

No

CPF_0676

110798651

purN

phosphoribosylglycinamide formyltransfer...

204

conserved gene; putative drug target function;

Phase 4: April 2009

2YWR

42.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90799
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3577

16123721

D-arabinose 5-phosphate isomerase [Yersi...

328

Predicted Essential

Community Requests

2XHZ

42.4%

Yersinia pestis

IDP02171
(show subtarget assignments)

1

soluble

No

CBU_0894

29541483

folC

FolC bifunctional protein [Coxiella burn...

416

Conserved; Drug target functions

Phase 3: June 2008

1W78

42.5%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02089
(show subtarget assignments)

1

cloned

No

CBU_0424

29541033

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

266

Conserved; Drug target functions

Phase 3: June 2008

1OY0

42.5%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00921
(show subtarget assignments)

1

purified

No

STM0507

16763887

ybbA

putative ABC transporter ATP-binding pro...

228

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

42.5%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP92040
(show subtarget assignments)

8

selected

No

TGME49_039310

237834547

ribose 5-phosphate isomerase, putative [...

259

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2F8M

42.5%

Toxoplasma gondii

IDP91992
(show subtarget assignments)

8

purified

No

SpneCM_010100001714

298254315

sortase [Streptococcus pneumoniae str. C...

247

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3FN5

42.5%

Streptococcus pneumoniae