Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90941 (show subtarget assignments)	8	expressed	No	NMPDR 214092.1.peg.4098				246	Predicted Essential	Community Requests	2PB0	66.3%	Yersinia pestis

IDP01113 (show subtarget assignments)	1	expressed	No	BA_0368	30253903		amino acid ABC transporter, ATP-binding ...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	65.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP04642 (show subtarget assignments)	1	expressed	No	FTT0716	56707835	upp	uracil phosphoribosyltransferase [Franci...	214	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2EHJ	69.2%	Francisella tularensis

IDP02239 (show subtarget assignments)	1	expressed	No	GBAA0299	47525562	purD	phosphoribosylamine--glycine ligase [Bac...	423	Conserved; Drug target functions	Phase 3: June 2008	2YRW	64.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02238 (show subtarget assignments)	1	expressed	No	YPO0815	16121126		general secretion pathway protein E [Yer...	503	Conserved; CD; Drug target functions	Phase 3: June 2008	1P9R	48.3%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP90932 (show subtarget assignments)	8	expressed	No	YPO2428	16122648	pheT	phenylalanyl-tRNA synthetase subunit bet...	795	Predicted Essential	Community Requests	3PCO	83.4%	Yersinia pestis

IDP90917 (show subtarget assignments)	8	expressed	No	Q9KV30	41019520		RecName: Full=DNA-directed RNA polymeras...	1341	Predicted Essential	Community Requests	3IYD	85.3%	Vibrio cholerae

IDP02232 (show subtarget assignments)	1	expressed	No	FTT1050c	56708136	cysN	sulfate adenylate transferase subunit 1 ...	470	Drug Target	Phase 3: June 2008	1ZUN	56%	Francisella tularensis	Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo	Serine familySulfur metabolism,Purine ribonucleotide biosynthesis

IDP90919 (show subtarget assignments)	8	expressed	No	YPO2608	16122821	holA	DNA polymerase III subunit delta [Yersin...	344	Predicted Essential	Community Requests	1JQJ	71.5%	Yersinia pestis

IDP04089 (show subtarget assignments)	1	expressed	No	STM1952_1_222	16765290	yecS	putative ABC-type amino acid transporter...	222	Salmonella essential protein	Phase 4: April 2009	2R6G	24.3%	Salmonella enterica

IDP04189 (show subtarget assignments)	1	expressed	No	CPF_0225	110799110		sensor histidine kinase [Clostridium per...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	13%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP00271 (show subtarget assignments)	1	expressed	No	AF180817_115-280	7329982	N/A	Premembrane/Membrane protein (prM)	166	Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds	Phase 3: June 2008	3C5X	59.6%	Dengue virus		N/A

IDP04638 (show subtarget assignments)	1	expressed	No	FTT0372c	56707523	accD	Acetyl-CoA carboxylase beta subunit [Fra...	302	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	60.3%	Francisella tularensis

IDP90920 (show subtarget assignments)	8	expressed	No	VC0021	15640053	glyQ	glycyl-tRNA synthetase subunit alpha [Vi...	330	Predicted Essential	Community Requests	3RF1	56.4%	Vibrio cholerae

IDP90933 (show subtarget assignments)	8	expressed	No	YPO3759	16123896	birA	biotin--protein ligase [Yersinia pestis ...	319	Predicted Essential	Community Requests	1BIA	75.2%	Yersinia pestis

IDP04094 (show subtarget assignments)	1	expressed	No	YPO1966	218929080	astE	succinylglutamate desuccinylase [Yersini...	330	conserved gene; putative drug target function;	Phase 4: April 2009	1YW6	47.9%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP90897 (show subtarget assignments)	8	expressed	No	VC0956	15640972	leuS	leucyl-tRNA synthetase [Vibrio cholerae ...	894	Predicted Essential	Community Requests	1H3N	46.3%	Vibrio cholerae

IDP02223 (show subtarget assignments)	1	expressed	No	YPO0550	16120878	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	490	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1E8C	76.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04086 (show subtarget assignments)	1	expressed	No	VC2256	15642254		undecaprenyl diphosphate synthase [Vibri...	256	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1JP3	54.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04657 (show subtarget assignments)	1	expressed	No	FTT1721c	56708727	purF	amidophosphoribosyltransferase [Francise...	496	conserved gene; putative drug target function;	Phase 4: April 2009	1ECB	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01101 (show subtarget assignments)	1	expressed	No	GBAA_pXO1_0119	47566439		hypothetical protein GBAA_pXO1_0119	82	Virulence Associated Factor	Phase 2: March 2008	3SIK	52.4%	Bacillus anthracis

IDP02218 (show subtarget assignments)	1	expressed	No	GBAA2133	47778008	narA-1	molybdenum cofactor biosynthesis protein...	337	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TV7	54.4%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP90894 (show subtarget assignments)	8	expressed	No	YPO2046	16122285	argS	arginyl-tRNA synthetase [Yersinia pestis...	576	Predicted Essential	Community Requests	1BS2	31.1%	Yersinia pestis

IDP04099 (show subtarget assignments)	1	expressed	No	VC1027	9655490		molybdenum cofactor biosynthesis protein...	81	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1FM0	70.4%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP02213 (show subtarget assignments)	1	expressed	No	GBAA0068	47525322	pabB	para-aminobenzoate synthase component I ...	465	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1QDL	37.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP90893 (show subtarget assignments)	8	expressed	No	YPO3781	16123915	ubiE	ubiquinone/menaquinone biosynthesis meth...	251	Predicted Essential	Community Requests	2AVN	21.9%	Yersinia pestis

IDP90881 (show subtarget assignments)	8	expressed	No	VC0329	15640356		DNA-directed RNA polymerase subunit beta...	1401	Predicted Essential	Community Requests	3IYD	82.4%	Vibrio cholerae

IDP02207 (show subtarget assignments)	1	expressed	No	YPO0612	16120938		putative sugar binding protein [Yersinia...	414	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3QUF	24.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01088 (show subtarget assignments)	1	expressed	No	STM4512	16767756	iadA	isoaspartyl dipeptidase	390	Drug Target Function	Phase 2: March 2008	1ONX	81%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00570 (show subtarget assignments)	1	expressed	No	YPO2042	16122281		putative oxidoreductase	536	Conserved Gene / Pathway	Phase 2: March 2008	1TLT	34.9%	Yersinia pestis	Cellular processes	Pathogenesis

IDP05399 (show subtarget assignments)	1	expressed	No	BA_3541	30258076		conserved domain protein [Bacillus anthr...	170	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Domain

IDP90879 (show subtarget assignments)	8	expressed	No	YPO0909	16121214	ubiH	2-octaprenyl-6-methoxyphenyl hydroxylase...	392	Predicted Essential	Community Requests	2X3N	24.2%	Yersinia pestis

IDP02199 (show subtarget assignments)	1	expressed	No	CBU_1505	29542064	lepA	GTP-binding protein LepA [Coxiella burne...	614	Conserved; Drug target functions	Phase 3: June 2008	3CB4	69.9%	Coxiella burnetii	Unknown function	General

IDP00123 (show subtarget assignments)	1	expressed	No	NT01ST4633	16766997	rfaC	ADP-heptose:LPS heptosyl transferase I	317	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GT1	83.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02195 (show subtarget assignments)	1	expressed	No	FTT0084c	56707262	hemN	oxygen-independent coproporphyrinogen II...	380	Conserved; Drug target functions	Phase 3: June 2008	1OLT	22.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02194 (show subtarget assignments)	1	expressed	No	FTT0075	56707254	sdhB	succinate dehydrogenase iron-sulfur subu...	233	Conserved; Drug target functions	Phase 3: June 2008	1NEK	66.7%	Francisella tularensis	Energy metabolism	TCA cycle

IDP01082 (show subtarget assignments)	1	expressed	No	STM4279	16767529	nrfC	putative formate-dependent nitrite reduc...	223	Essential Gene	Phase 2: March 2008	2VPW	35.9%	Salmonella enterica	Energy metabolism	Electron transport

IDP04623 (show subtarget assignments)	1	expressed	No	BAS4760	49187751		glucose-1-phosphate adenylyltransferase ...	376	Proposed to be essential proteins	Phase 4: April 2009	3BRK	40%	Bacillus anthracis

IDP90872 (show subtarget assignments)	8	expressed	No	Cj1096c	15792421	metK	S-adenosylmethionine synthetase [Campylo...	398	Predicted Essential	Community Requests	3IML	41.7%	Campylobacter jejuni

IDP02191 (show subtarget assignments)	1	expressed	No	FTT0878c	56707982	msrB	methionine sulfoxide reductase B [Franci...	170	Drug Target	Phase 3: June 2008	1XM0	47.6%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein modification and repair

IDP02190 (show subtarget assignments)	1	expressed	No	YPO0360	16120695	frdA	fumarate reductase flavoprotein subunit ...	607	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1KF6	85.2%	Yersinia pestis	Energy metabolism	Anaerobic

IDP02188 (show subtarget assignments)	1	expressed	No	YPO0267	16120605		type III secretion system ATPase [Yersin...	445	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008	2DPY	43.6%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP90874 (show subtarget assignments)	8	expressed	No	YPO1054	16121354	lpxD	UDP-3-O-[3-hydroxymyristoyl] glucosamine...	340	Predicted Essential	Community Requests	3EH0	82.4%	Yersinia pestis

IDP02184 (show subtarget assignments)	1	expressed	No	CBU_1352	29541917	ftsH	ATP-dependent metalloprotease FtsH [Coxi...	647	Conserved; Drug target functions	Phase 3: June 2008	2CE7	41.6%	Coxiella burnetii	Cellular processes	Cell division

IDP01076 (show subtarget assignments)	8	expressed	No	STM4120	16767385	argE	acetylornithine deacetylase	383	Drug Target Function	Community Requests	3CT9	25.1%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP05393 (show subtarget assignments)	1	expressed	No	BA_3225	30257788		hypothetical protein BA_3225 [Bacillus a...	200	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP00264 (show subtarget assignments)	1	expressed	No	NP_056776_2244-2491	159024209	N/A	NS4B	248	possibly RNA replication	Phase 3: June 2008			Dengue virus	Transcription	N/A

IDP02173 (show subtarget assignments)	1	expressed	No	Cj1136	15792461		putative galactosyltransferase [Campylob...	390	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3L7I	20.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04617 (show subtarget assignments)	1	expressed	No	BAS4342	49187337		50S ribosomal protein L21 [Bacillus anth...	102	Proposed to be essential proteins	Phase 4: April 2009	1VSA	54.9%	Bacillus anthracis

IDP01070 (show subtarget assignments)	1	expressed	No	STM3949	16767219	xerC	site-specific tyrosine recombinase XerC ...	300	Drug Target Function	Phase 2: March 2008	1A0P	37.3%	Salmonella enterica	Cellular processes	Cell division

IDP02168 (show subtarget assignments)	1	expressed	No	CBU_1289	29541857	dnaJ	chaperone protein dnaJ [Coxiella burneti...	374	Conserved; Drug target functions	Phase 3: June 2008	3LZ8	32.1%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP90857 (show subtarget assignments)	8	expressed	No	YPO1614	16121882		hypothetical protein YPO1614 [Yersinia p...	268	Predicted Essential	Community Requests			Yersinia pestis

IDP02167 (show subtarget assignments)	1	expressed	No	CBU_0886	29541477	coaBC	phosphopantothenoylcysteine decarboxylas...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01067 (show subtarget assignments)	1	expressed	No	STM3854	16767138	pstB	phosphate transporter subunit	257	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	36.2%	Salmonella enterica	Transport and binding proteins	Anions

IDP90859 (show subtarget assignments)	8	expressed	No	Cj1494c	15792809	carA	carbamoyl phosphate synthase small subun...	372	Predicted Essential	Community Requests	1BXR	40.3%	Campylobacter jejuni

IDP90864 (show subtarget assignments)	8	expressed	No	Cj0405	15791772	aroE	shikimate 5-dehydrogenase [Campylobacter...	262	Predicted Essential	Community Requests	3PHG	38.5%	Campylobacter jejuni

IDP01066 (show subtarget assignments)	1	expressed	No	STM3819	16767104	ccmA	heme exporter protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	32.7%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP04188 (show subtarget assignments)	1	expressed	No	VCA0939	15601692		sensory box/GGDEF family protein [Vibrio...	321	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3BRE	20.6%	Vibrio cholerae	Regulatory functions	Other

IDP01065 (show subtarget assignments)	1	expressed	No	STM3722	16767007	rfaG	glucosyltransferase I	374	Drug Target Function	Phase 2: March 2008	2IV7	86.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02157 (show subtarget assignments)	1	expressed	No	GBAA3961	47778228	uppS	undecaprenyl diphosphate synthase [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1F75	55.8%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP90840 (show subtarget assignments)	8	expressed	No	S1634	30063019	pheS	phenylalanyl-tRNA synthetase subunit alp...	327	Predicted Essential	Community Requests	3PCO	99.4%	Shigella flexneri

IDP02154 (show subtarget assignments)	1	expressed	No	GBAA2526	47527815		D-alanyl-D-alanine carboxypeptidase fami...	243	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02153 (show subtarget assignments)	1	expressed	No	CBU_0884	29541475	bipA	virulence regulator BipA [Coxiella burne...	602	Conserved; Drug target functions	Phase 3: June 2008	3E3X	34.6%	Coxiella burnetii	Cellular processes	Pathogenesis

IDP04085 (show subtarget assignments)	1	expressed	No	VC0525	15640547		2-amino-4-hydroxy-6-hydroxymethyldihydro...	195	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2BMB	30.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP05401 (show subtarget assignments)	1	expressed	No	BA_4365	30258863		hypothetical protein BA_4365 [Bacillus a...	83	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP00120 (show subtarget assignments)	1	expressed	No	NT01ST0780	16764019	ybeB	hypothetical protein STM0642	105	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2ID1	38.1%	Salmonella enterica	Cell envelope	Other

IDP90852 (show subtarget assignments)	8	expressed	No	VC2018	15642020		4-amino-4-deoxychorismate lyase [Vibrio ...	277	Predicted Essential	Community Requests	1ET0	34.3%	Vibrio cholerae

IDP90827 (show subtarget assignments)	8	expressed	No	Cj0514	15791876	purQ	phosphoribosylformylglycinamidine syntha...	223	Predicted Essential	Community Requests	3D54	40.4%	Campylobacter jejuni

IDP02143 (show subtarget assignments)	1	expressed	No	CBU_0739	29541339	clpX	ATP-dependent Clp protease, ATP-binding ...	422	Conserved; Drug target functions	Phase 3: June 2008	3HTE	59.5%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02138 (show subtarget assignments)	1	expressed	No	Cj0580c	15791940		coproporphyrinogen III oxidase [Campylob...	355	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1OLT	22.5%	Campylobacter jejuni	Amino acid biosynthesis	Pyruvate family

IDP04078 (show subtarget assignments)	1	expressed	No	YPCD1.09c	5832432	YPCD1.09c	hypothetical protein YPCD1.09c [Yersinia...	91	virulence factor; conserved gene;	Phase 4: April 2009	3KXE	29.7%	Yersinia pestis	Hypothetical proteins	Conserved

IDP90818 (show subtarget assignments)	8	expressed	No	YPO1059	16121359	dnaE	DNA polymerase III subunit alpha [Yersin...	1171	Predicted Essential	Community Requests	2HQA	70%	Yersinia pestis

IDP04076 (show subtarget assignments)	1	expressed	No	GBAA2213	47527506		sensor histidine kinase [Bacillus anthra...	452	putative drug target function;	Phase 4: April 2009	2C2A	18.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01052 (show subtarget assignments)	1	expressed	No	STM3324	16766619	ptsO	phosphohistidinoprotein-hexose phosphotr...	90	Conserved Gene / Pathway	Phase 2: March 2008	1JEM	34.4%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02133 (show subtarget assignments)	1	expressed	No	YPO0054	16120407	kdtX	lipopolysaccharide core biosynthesis gly...	260	Drug target motif; Involved in virulence; Drug target functions	Phase 3: June 2008	3E25	11.5%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01051 (show subtarget assignments)	1	expressed	No	STM3219	16766518	fadH	2,4-dieonyl-CoA reductase	672	Drug Target Function	Phase 2: March 2008	1PS9	85.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP90830 (show subtarget assignments)	8	expressed	No	YPO2527	16122746	menD	2-succinyl-6-hydroxy-2,4-cyclohexadiene-...	567	Predicted Essential	Community Requests	2JLA	69%	Yersinia pestis

IDP04597 (show subtarget assignments)	1	expressed	No	BAS1384	49184401		resB protein [Bacillus anthracis str. St...	541	Proposed to be essential proteins	Phase 4: April 2009			Bacillus anthracis

IDP02129 (show subtarget assignments)	1	expressed	No	CBU_0450	29541057	ffh	signal recognition particle protein [Cox...	461	Conserved; Drug target functions	Phase 3: June 2008	2XXA	57.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP00553 (show subtarget assignments)	1	expressed	No	YPO3939	16124067	glgA	glycogen synthase	476	Drug Target Function	Phase 2: March 2008	2QZS	71.4%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00256 (show subtarget assignments)	1	expressed	No	RBVgp1	21397175		Rio Bravo bat virus Envelope protein	395	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1URZ	43.2%	Rio Bravo

IDP05375 (show subtarget assignments)	1	expressed	No	BA_4118	30258624		hypothetical protein BA_4118 [Bacillus a...	57	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP01046 (show subtarget assignments)	1	expressed	No	STM3138	16766438		putative methyl-accepting chemotaxis pro...	352	Conserved Gene / Pathway	Phase 2: March 2008	1QU7	16.8%	Salmonella enterica	Cellular processes	Other

IDP02120 (show subtarget assignments)	1	expressed	No	YPO0027	16120380		phosphatase [Yersinia pestis CO92]	196	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2B0C	66.8%	Yersinia pestis	Unknown function	General

IDP04185 (show subtarget assignments)	1	expressed	No	VCA0683	15601440		sensor protein UhpB [Vibrio cholerae O1 ...	527	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3GIG	12%	Vibrio cholerae	Regulatory functions	Other

IDP04589 (show subtarget assignments)	1	expressed	No	BAS0135	49183169		30S ribosomal protein S13 [Bacillus anth...	121	Proposed to be essential proteins	Phase 4: April 2009	1FJG	63.9%	Bacillus anthracis

IDP04590 (show subtarget assignments)	1	expressed	No	BAS0136	49183170		30S ribosomal protein S11 [Bacillus anth...	129	Proposed to be essential proteins	Phase 4: April 2009	1VS5	65.9%	Bacillus anthracis

IDP01040 (show subtarget assignments)	1	expressed	No	STM2935	16766241	cysD	sulfate adenylyltransferase subunit 2	302	Conserved Gene / Pathway	Phase 2: March 2008	1ZUN	75.2%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP02110 (show subtarget assignments)	1	expressed	No	STM3820	16767105		putative cytochrome c peroxidase [Salmon...	466	Conserved; Drug target functions	Phase 3: June 2008	1IQC	29.4%	Salmonella enterica	Cellular processes	Detoxification

IDP01039 (show subtarget assignments)	1	expressed	No	STM2934	16766240	cysN	sulfate adenylyltransferase subunit 1	479	Conserved Gene / Pathway	Phase 2: March 2008	1ZUN	52.4%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP04068 (show subtarget assignments)	1	expressed	No	YPCD1.94n	40548799		hypothetical protein YPCD1.94n [Yersinia...	251	virulence factor;	Phase 4: April 2009	1A5V	15.1%	Yersinia pestis

IDP00547 (show subtarget assignments)	1	expressed	No	YPO3813	16123947	ftsE	cell division protein FtsE	222	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	39.6%	Yersinia pestis	Cellular processes	Cell division

IDP05365 (show subtarget assignments)	1	expressed	No	BA_2909	30257501		hypothetical protein BA_2909 [Bacillus a...	56	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP02103 (show subtarget assignments)	1	expressed	No	YPO0891	16121196	dsbC	thiol:disulfide interchange protein DsbC...	238	Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...	Phase 3: June 2008	1JZD	61.8%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP02101 (show subtarget assignments)	1	expressed	No	STM3638	16766924	lpfC	long polar fimbrial outer membrane usher...	842	Conserved; Drug target functions	Phase 3: June 2008	3RFZ	44.8%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP00546 (show subtarget assignments)	1	expressed	No	YPO0359	16120694	frdB	fumarate reductase iron-sulfur subunit	244	Virulence Associated Factor	Phase 2: March 2008	1KF6	84.8%	Yersinia pestis	Energy metabolism	Anaerobic

IDP04592 (show subtarget assignments)	1	expressed	No	BAS0143	49183177		50S ribosomal protein L13 [Bacillus anth...	145	Proposed to be essential proteins	Phase 4: April 2009	1P85	56.6%	Bacillus anthracis

IDP90759 (show subtarget assignments)	8	expressed	No	YPO0553	16120881	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	438	Predicted Essential	Community Requests	1E0D	80.6%	Yersinia pestis

IDP02091 (show subtarget assignments)	1	expressed	No	STM3515	16766803	malT	transcriptional regulator MalT [Salmonel...	901	Conserved; Drug target functions	Phase 3: June 2008	1HZ4	36.6%	Salmonella enterica	Energy metabolism	Other

IDP90760 (show subtarget assignments)	8	expressed	No	Cj0686	15792035	ispG	4-hydroxy-3-methylbut-2-en-1-yl diphosph...	357	Predicted Essential	Community Requests	3NOY	47.1%	Campylobacter jejuni

IDP90941
(show subtarget assignments)

8

expressed

No

NMPDR 214092.1.peg.4098

246

Predicted Essential

Community Requests

2PB0

66.3%

Yersinia pestis

IDP01113
(show subtarget assignments)

1

expressed

No

BA_0368

30253903

amino acid ABC transporter, ATP-binding ...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

65.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP04642
(show subtarget assignments)

1

expressed

No

FTT0716

56707835

upp

uracil phosphoribosyltransferase [Franci...

214

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2EHJ

69.2%

Francisella tularensis

IDP02239
(show subtarget assignments)

1

expressed

No

GBAA0299

47525562

purD

phosphoribosylamine--glycine ligase [Bac...

423

Conserved; Drug target functions

Phase 3: June 2008

2YRW

64.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02238
(show subtarget assignments)

1

expressed

No

YPO0815

16121126

general secretion pathway protein E [Yer...

503

Conserved; CD; Drug target functions

Phase 3: June 2008

1P9R

48.3%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP90932
(show subtarget assignments)

8

expressed

No

YPO2428

16122648

pheT

phenylalanyl-tRNA synthetase subunit bet...

795

Predicted Essential

Community Requests

3PCO

83.4%

Yersinia pestis

IDP90917
(show subtarget assignments)

8

expressed

No

Q9KV30

41019520

RecName: Full=DNA-directed RNA polymeras...

1341

Predicted Essential

Community Requests

3IYD

85.3%

Vibrio cholerae

IDP02232
(show subtarget assignments)

1

expressed

No

FTT1050c

56708136

cysN

sulfate adenylate transferase subunit 1 ...

470

Drug Target

Phase 3: June 2008

1ZUN

56%

Francisella tularensis

Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo

Serine familySulfur metabolism,Purine ribonucleotide biosynthesis

IDP90919
(show subtarget assignments)

8

expressed

No

YPO2608

16122821

holA

DNA polymerase III subunit delta [Yersin...

344

Predicted Essential

Community Requests

1JQJ

71.5%

Yersinia pestis

IDP04089
(show subtarget assignments)

1

expressed

No

STM1952_1_222

16765290

yecS

putative ABC-type amino acid transporter...

222

Salmonella essential protein

Phase 4: April 2009

2R6G

24.3%

Salmonella enterica

IDP04189
(show subtarget assignments)

1

expressed

No

CPF_0225

110799110

sensor histidine kinase [Clostridium per...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

13%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP00271
(show subtarget assignments)

1

expressed

No

AF180817_115-280

7329982

N/A

Premembrane/Membrane protein (prM)

166

Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds

Phase 3: June 2008

3C5X

59.6%

Dengue virus

N/A

IDP04638
(show subtarget assignments)

1

expressed

No

FTT0372c

56707523

accD

Acetyl-CoA carboxylase beta subunit [Fra...

302

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

60.3%

Francisella tularensis

IDP90920
(show subtarget assignments)

8

expressed

No

VC0021

15640053

glyQ

glycyl-tRNA synthetase subunit alpha [Vi...

330

Predicted Essential

Community Requests

3RF1

56.4%

Vibrio cholerae

IDP90933
(show subtarget assignments)

8

expressed

No

YPO3759

16123896

birA

biotin--protein ligase [Yersinia pestis ...

319

Predicted Essential

Community Requests

1BIA

75.2%

Yersinia pestis

IDP04094
(show subtarget assignments)

1

expressed

No

YPO1966

218929080

astE

succinylglutamate desuccinylase [Yersini...

330

conserved gene; putative drug target function;

Phase 4: April 2009

1YW6

47.9%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP90897
(show subtarget assignments)

8

expressed

No

VC0956

15640972

leuS

leucyl-tRNA synthetase [Vibrio cholerae ...

894

Predicted Essential

Community Requests

1H3N

46.3%

Vibrio cholerae

IDP02223
(show subtarget assignments)

1

expressed

No

YPO0550

16120878

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

490

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1E8C

76.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04086
(show subtarget assignments)

1

expressed

No

VC2256

15642254

undecaprenyl diphosphate synthase [Vibri...

256

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1JP3

54.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04657
(show subtarget assignments)

1

expressed

No

FTT1721c

56708727

purF

amidophosphoribosyltransferase [Francise...

496

conserved gene; putative drug target function;

Phase 4: April 2009

1ECB

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01101
(show subtarget assignments)

1

expressed

No

GBAA_pXO1_0119

47566439

hypothetical protein GBAA_pXO1_0119

82

Virulence Associated Factor

Phase 2: March 2008

3SIK

52.4%

Bacillus anthracis

IDP02218
(show subtarget assignments)

1

expressed

No

GBAA2133

47778008

narA-1

molybdenum cofactor biosynthesis protein...

337

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TV7

54.4%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP90894
(show subtarget assignments)

8

expressed

No

YPO2046

16122285

argS

arginyl-tRNA synthetase [Yersinia pestis...

576

Predicted Essential

Community Requests

1BS2

31.1%

Yersinia pestis

IDP04099
(show subtarget assignments)

1

expressed

No

VC1027

9655490

molybdenum cofactor biosynthesis protein...

81

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1FM0

70.4%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP02213
(show subtarget assignments)

1

expressed

No

GBAA0068

47525322

pabB

para-aminobenzoate synthase component I ...

465

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1QDL

37.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP90893
(show subtarget assignments)

8

expressed

No

YPO3781

16123915

ubiE

ubiquinone/menaquinone biosynthesis meth...

251

Predicted Essential

Community Requests

2AVN

21.9%

Yersinia pestis

IDP90881
(show subtarget assignments)

8

expressed

No

VC0329

15640356

DNA-directed RNA polymerase subunit beta...

1401

Predicted Essential

Community Requests

3IYD

82.4%

Vibrio cholerae

IDP02207
(show subtarget assignments)

1

expressed

No

YPO0612

16120938

putative sugar binding protein [Yersinia...

414

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3QUF

24.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01088
(show subtarget assignments)

1

expressed

No

STM4512

16767756

iadA

isoaspartyl dipeptidase

390

Drug Target Function

Phase 2: March 2008

1ONX

81%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00570
(show subtarget assignments)

1

expressed

No

YPO2042

16122281

putative oxidoreductase

536

Conserved Gene / Pathway

Phase 2: March 2008

1TLT

34.9%

Yersinia pestis

Cellular processes

Pathogenesis

IDP05399
(show subtarget assignments)

1

expressed

No

BA_3541

30258076

conserved domain protein [Bacillus anthr...

170

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Domain

IDP90879
(show subtarget assignments)

8

expressed

No

YPO0909

16121214

ubiH

2-octaprenyl-6-methoxyphenyl hydroxylase...

392

Predicted Essential

Community Requests

2X3N

24.2%

Yersinia pestis

IDP02199
(show subtarget assignments)

1

expressed

No

CBU_1505

29542064

lepA

GTP-binding protein LepA [Coxiella burne...

614

Conserved; Drug target functions

Phase 3: June 2008

3CB4

69.9%

Coxiella burnetii

Unknown function

General

IDP00123
(show subtarget assignments)

1

expressed

No

NT01ST4633

16766997

rfaC

ADP-heptose:LPS heptosyl transferase I

317

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GT1

83.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02195
(show subtarget assignments)

1

expressed

No

FTT0084c

56707262

hemN

oxygen-independent coproporphyrinogen II...

380

Conserved; Drug target functions

Phase 3: June 2008

1OLT

22.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02194
(show subtarget assignments)

1

expressed

No

FTT0075

56707254

sdhB

succinate dehydrogenase iron-sulfur subu...

233

Conserved; Drug target functions

Phase 3: June 2008

1NEK

66.7%

Francisella tularensis

Energy metabolism

TCA cycle

IDP01082
(show subtarget assignments)

1

expressed

No

STM4279

16767529

nrfC

putative formate-dependent nitrite reduc...

223

Essential Gene

Phase 2: March 2008

2VPW

35.9%

Salmonella enterica

Energy metabolism

Electron transport

IDP04623
(show subtarget assignments)

1

expressed

No

BAS4760

49187751

glucose-1-phosphate adenylyltransferase ...

376

Proposed to be essential proteins

Phase 4: April 2009

3BRK

40%

Bacillus anthracis

IDP90872
(show subtarget assignments)

8

expressed

No

Cj1096c

15792421

metK

S-adenosylmethionine synthetase [Campylo...

398

Predicted Essential

Community Requests

3IML

41.7%

Campylobacter jejuni

IDP02191
(show subtarget assignments)

1

expressed

No

FTT0878c

56707982

msrB

methionine sulfoxide reductase B [Franci...

170

Drug Target

Phase 3: June 2008

1XM0

47.6%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein modification and repair

IDP02190
(show subtarget assignments)

1

expressed

No

YPO0360

16120695

frdA

fumarate reductase flavoprotein subunit ...

607

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1KF6

85.2%

Yersinia pestis

Energy metabolism

Anaerobic

IDP02188
(show subtarget assignments)

1

expressed

No

YPO0267

16120605

type III secretion system ATPase [Yersin...

445

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

2DPY

43.6%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP90874
(show subtarget assignments)

8

expressed

No

YPO1054

16121354

lpxD

UDP-3-O-[3-hydroxymyristoyl] glucosamine...

340

Predicted Essential

Community Requests

3EH0

82.4%

Yersinia pestis

IDP02184
(show subtarget assignments)

1

expressed

No

CBU_1352

29541917

ftsH

ATP-dependent metalloprotease FtsH [Coxi...

647

Conserved; Drug target functions

Phase 3: June 2008

2CE7

41.6%

Coxiella burnetii

Cellular processes

Cell division

IDP01076
(show subtarget assignments)

8

expressed

No

STM4120

16767385

argE

acetylornithine deacetylase

383

Drug Target Function

Community Requests

3CT9

25.1%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP05393
(show subtarget assignments)

1

expressed

No

BA_3225

30257788

hypothetical protein BA_3225 [Bacillus a...

200

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP00264
(show subtarget assignments)

1

expressed

No

NP_056776_2244-2491

159024209

N/A

NS4B

248

possibly RNA replication

Phase 3: June 2008

Dengue virus

Transcription

N/A

IDP02173
(show subtarget assignments)

1

expressed

No

Cj1136

15792461

putative galactosyltransferase [Campylob...

390

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3L7I

20.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04617
(show subtarget assignments)

1

expressed

No

BAS4342

49187337

50S ribosomal protein L21 [Bacillus anth...

102

Proposed to be essential proteins

Phase 4: April 2009

1VSA

54.9%

Bacillus anthracis

IDP01070
(show subtarget assignments)

1

expressed

No

STM3949

16767219

xerC

site-specific tyrosine recombinase XerC ...

300

Drug Target Function

Phase 2: March 2008

1A0P

37.3%

Salmonella enterica

Cellular processes

Cell division

IDP02168
(show subtarget assignments)

1

expressed

No

CBU_1289

29541857

dnaJ

chaperone protein dnaJ [Coxiella burneti...

374

Conserved; Drug target functions

Phase 3: June 2008

3LZ8

32.1%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP90857
(show subtarget assignments)

8

expressed

No

YPO1614

16121882

hypothetical protein YPO1614 [Yersinia p...

268

Predicted Essential

Community Requests

Yersinia pestis

IDP02167
(show subtarget assignments)

1

expressed

No

CBU_0886

29541477

coaBC

phosphopantothenoylcysteine decarboxylas...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01067
(show subtarget assignments)

1

expressed

No

STM3854

16767138

pstB

phosphate transporter subunit

257

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

36.2%

Salmonella enterica

Transport and binding proteins

Anions

IDP90859
(show subtarget assignments)

8

expressed

No

Cj1494c

15792809

carA

carbamoyl phosphate synthase small subun...

372

Predicted Essential

Community Requests

1BXR

40.3%

Campylobacter jejuni

IDP90864
(show subtarget assignments)

8

expressed

No

Cj0405

15791772

aroE

shikimate 5-dehydrogenase [Campylobacter...

262

Predicted Essential

Community Requests

3PHG

38.5%

Campylobacter jejuni

IDP01066
(show subtarget assignments)

1

expressed

No

STM3819

16767104

ccmA

heme exporter protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

32.7%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP04188
(show subtarget assignments)

1

expressed

No

VCA0939

15601692

sensory box/GGDEF family protein [Vibrio...

321

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3BRE

20.6%

Vibrio cholerae

Regulatory functions

Other

IDP01065
(show subtarget assignments)

1

expressed

No

STM3722

16767007

rfaG

glucosyltransferase I

374

Drug Target Function

Phase 2: March 2008

2IV7

86.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02157
(show subtarget assignments)

1

expressed

No

GBAA3961

47778228

uppS

undecaprenyl diphosphate synthase [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1F75

55.8%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP90840
(show subtarget assignments)

8

expressed

No

S1634

30063019

pheS

phenylalanyl-tRNA synthetase subunit alp...

327

Predicted Essential

Community Requests

3PCO

99.4%

Shigella flexneri

IDP02154
(show subtarget assignments)

1

expressed

No

GBAA2526

47527815

D-alanyl-D-alanine carboxypeptidase fami...

243

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02153
(show subtarget assignments)

1

expressed

No

CBU_0884

29541475

bipA

virulence regulator BipA [Coxiella burne...

602

Conserved; Drug target functions

Phase 3: June 2008

3E3X

34.6%

Coxiella burnetii

Cellular processes

Pathogenesis

IDP04085
(show subtarget assignments)

1

expressed

No

VC0525

15640547

2-amino-4-hydroxy-6-hydroxymethyldihydro...

195

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2BMB

30.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP05401
(show subtarget assignments)

1

expressed

No

BA_4365

30258863

hypothetical protein BA_4365 [Bacillus a...

83

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP00120
(show subtarget assignments)

1

expressed

No

NT01ST0780

16764019

ybeB

hypothetical protein STM0642

105

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2ID1

38.1%

Salmonella enterica

Cell envelope

Other

IDP90852
(show subtarget assignments)

8

expressed

No

VC2018

15642020

4-amino-4-deoxychorismate lyase [Vibrio ...

277

Predicted Essential

Community Requests

1ET0

34.3%

Vibrio cholerae

IDP90827
(show subtarget assignments)

8

expressed

No

Cj0514

15791876

purQ

phosphoribosylformylglycinamidine syntha...

223

Predicted Essential

Community Requests

3D54

40.4%

Campylobacter jejuni

IDP02143
(show subtarget assignments)

1

expressed

No

CBU_0739

29541339

clpX

ATP-dependent Clp protease, ATP-binding ...

422

Conserved; Drug target functions

Phase 3: June 2008

3HTE

59.5%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02138
(show subtarget assignments)

1

expressed

No

Cj0580c

15791940

coproporphyrinogen III oxidase [Campylob...

355

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1OLT

22.5%

Campylobacter jejuni

Amino acid biosynthesis

Pyruvate family

IDP04078
(show subtarget assignments)

1

expressed

No

YPCD1.09c

5832432

YPCD1.09c

hypothetical protein YPCD1.09c [Yersinia...

91

virulence factor; conserved gene;

Phase 4: April 2009

3KXE

29.7%

Yersinia pestis

Hypothetical proteins

Conserved

IDP90818
(show subtarget assignments)

8

expressed

No

YPO1059

16121359

dnaE

DNA polymerase III subunit alpha [Yersin...

1171

Predicted Essential

Community Requests

2HQA

70%

Yersinia pestis

IDP04076
(show subtarget assignments)

1

expressed

No

GBAA2213

47527506

sensor histidine kinase [Bacillus anthra...

452

putative drug target function;

Phase 4: April 2009

2C2A

18.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01052
(show subtarget assignments)

1

expressed

No

STM3324

16766619

ptsO

phosphohistidinoprotein-hexose phosphotr...

90

Conserved Gene / Pathway

Phase 2: March 2008

1JEM

34.4%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02133
(show subtarget assignments)

1

expressed

No

YPO0054

16120407

kdtX

lipopolysaccharide core biosynthesis gly...

260

Drug target motif; Involved in virulence; Drug target functions

Phase 3: June 2008

3E25

11.5%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01051
(show subtarget assignments)

1

expressed

No

STM3219

16766518

fadH

2,4-dieonyl-CoA reductase

672

Drug Target Function

Phase 2: March 2008

1PS9

85.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP90830
(show subtarget assignments)

8

expressed

No

YPO2527

16122746

menD

2-succinyl-6-hydroxy-2,4-cyclohexadiene-...

567

Predicted Essential

Community Requests

2JLA

69%

Yersinia pestis

IDP04597
(show subtarget assignments)

1

expressed

No

BAS1384

49184401

resB protein [Bacillus anthracis str. St...

541

Proposed to be essential proteins

Phase 4: April 2009

Bacillus anthracis

IDP02129
(show subtarget assignments)

1

expressed

No

CBU_0450

29541057

ffh

signal recognition particle protein [Cox...

461

Conserved; Drug target functions

Phase 3: June 2008

2XXA

57.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP00553
(show subtarget assignments)

1

expressed

No

YPO3939

16124067

glgA

glycogen synthase

476

Drug Target Function

Phase 2: March 2008

2QZS

71.4%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00256
(show subtarget assignments)

1

expressed

No

RBVgp1

21397175

Rio Bravo bat virus Envelope protein

395

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1URZ

43.2%

Rio Bravo

IDP05375
(show subtarget assignments)

1

expressed

No

BA_4118

30258624

hypothetical protein BA_4118 [Bacillus a...

57

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP01046
(show subtarget assignments)

1

expressed

No

STM3138

16766438

putative methyl-accepting chemotaxis pro...

352

Conserved Gene / Pathway

Phase 2: March 2008

1QU7

16.8%

Salmonella enterica

Cellular processes

Other

IDP02120
(show subtarget assignments)

1

expressed

No

YPO0027

16120380

phosphatase [Yersinia pestis CO92]

196

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2B0C

66.8%

Yersinia pestis

Unknown function

General

IDP04185
(show subtarget assignments)

1

expressed

No

VCA0683

15601440

sensor protein UhpB [Vibrio cholerae O1 ...

527

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3GIG

12%

Vibrio cholerae

Regulatory functions

Other

IDP04589
(show subtarget assignments)

1

expressed

No

BAS0135

49183169

30S ribosomal protein S13 [Bacillus anth...

121

Proposed to be essential proteins

Phase 4: April 2009

1FJG

63.9%

Bacillus anthracis

IDP04590
(show subtarget assignments)

1

expressed

No

BAS0136

49183170

30S ribosomal protein S11 [Bacillus anth...

129

Proposed to be essential proteins

Phase 4: April 2009

1VS5

65.9%

Bacillus anthracis

IDP01040
(show subtarget assignments)

1

expressed

No

STM2935

16766241

cysD

sulfate adenylyltransferase subunit 2

302

Conserved Gene / Pathway

Phase 2: March 2008

1ZUN

75.2%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP02110
(show subtarget assignments)

1

expressed

No

STM3820

16767105

putative cytochrome c peroxidase [Salmon...

466

Conserved; Drug target functions

Phase 3: June 2008

1IQC

29.4%

Salmonella enterica

Cellular processes

Detoxification

IDP01039
(show subtarget assignments)

1

expressed

No

STM2934

16766240

cysN

sulfate adenylyltransferase subunit 1

479

Conserved Gene / Pathway

Phase 2: March 2008

1ZUN

52.4%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP04068
(show subtarget assignments)

1

expressed

No

YPCD1.94n

40548799

hypothetical protein YPCD1.94n [Yersinia...

251

virulence factor;

Phase 4: April 2009

1A5V

15.1%

Yersinia pestis

IDP00547
(show subtarget assignments)

1

expressed

No

YPO3813

16123947

ftsE

cell division protein FtsE

222

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

39.6%

Yersinia pestis

Cellular processes

Cell division

IDP05365
(show subtarget assignments)

1

expressed

No

BA_2909

30257501

hypothetical protein BA_2909 [Bacillus a...

56

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP02103
(show subtarget assignments)

1

expressed

No

YPO0891

16121196

dsbC

thiol:disulfide interchange protein DsbC...

238

Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...

Phase 3: June 2008

1JZD

61.8%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP02101
(show subtarget assignments)

1

expressed

No

STM3638

16766924

lpfC

long polar fimbrial outer membrane usher...

842

Conserved; Drug target functions

Phase 3: June 2008

3RFZ

44.8%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00546
(show subtarget assignments)

1

expressed

No

YPO0359

16120694

frdB

fumarate reductase iron-sulfur subunit

244

Virulence Associated Factor

Phase 2: March 2008

1KF6

84.8%

Yersinia pestis

Energy metabolism

Anaerobic

IDP04592
(show subtarget assignments)

1

expressed

No

BAS0143

49183177

50S ribosomal protein L13 [Bacillus anth...

145

Proposed to be essential proteins

Phase 4: April 2009

1P85

56.6%

Bacillus anthracis

IDP90759
(show subtarget assignments)

8

expressed

No

YPO0553

16120881

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

438

Predicted Essential

Community Requests

1E0D

80.6%

Yersinia pestis

IDP02091
(show subtarget assignments)

1

expressed

No

STM3515

16766803

malT

transcriptional regulator MalT [Salmonel...

901

Conserved; Drug target functions

Phase 3: June 2008

1HZ4

36.6%

Salmonella enterica

Energy metabolism

Other

IDP90760
(show subtarget assignments)

8

expressed

No

Cj0686

15792035

ispG

4-hydroxy-3-methylbut-2-en-1-yl diphosph...

357

Predicted Essential

Community Requests

3NOY

47.1%

Campylobacter jejuni

Targets