Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91096 (show subtarget assignments)	8	soluble	No	BPSL0876	52208929	kdsB	putative 3-deoxy-manno-octulosonate cyti...	278	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	3K8D	49.6%	Burkholderia pseudomallei

IDP90394 (show subtarget assignments)	8	expressed	No	CT_560	3329001		hypothetical protein [Chlamydia trachoma...	278	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP04547 (show subtarget assignments)	1	cloned	No	CPF_0581	110800184		amino acid ABC transporter, amino acid-b...	278	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PVU	30.2%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP91975 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100009843	298255879		ABC transporter substrate-binding protei...	278	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3HV1	60.1%	Streptococcus pneumoniae

IDP04629 (show subtarget assignments)	1	soluble	No	CBU_0151	29653509	queF	7-cyano-7-deazaguanine reductase [Coxiel...	278	drug target; conserved gene;	Phase 4: April 2009	3BP1	51.4%	Coxiella burnetii	Hypothetical proteins	Conserved

IDP00614 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2109	57286325		modification methylase, HemK family	278	Drug Target Function	Phase 2: March 2008	1T43	32%	Staphylococcus aureus	Unknown function	General

IDP90792 (show subtarget assignments)	8	in_pdb 3PGJ 3O8Q 3SEF	Yes	VC0056	15640088	aroE	shikimate 5-dehydrogenase [Vibrio choler...	278	Predicted Essential	Community Requests	3O8Q	100%	Vibrio cholerae

IDP05596 (show subtarget assignments)	1	cloned	No	BA_3366	30257909		putative lipoprotein [Bacillus anthracis...	278	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP00061 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4399	30258896		hemolysin A	279	Virulence	Phase 1: October 2007	3HP7	58.4%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00565 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0281	16120620	hmuT	hemin-binding periplasmic protein	279	Conserved Gene / Pathway	Phase 2: March 2008	3MD9	91%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP01960 (show subtarget assignments)	1	soluble	No	CBU_0565	29541166		CBS domain protein [Coxiella burnetii RS...	279	Conserved; Drug target functions	Phase 3: June 2008	3LFR	27.2%	Coxiella burnetii	Unknown function	General

IDP04207 (show subtarget assignments)	1	soluble	No	CPF_2836	110801144		putative lipoprotein [Clostridium perfri...	279	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP91777 (show subtarget assignments)	8	purified	No	AAC33914	3513664	sul1	Sul1 dihydropteroate synthase [Escherich...	279	drug resistance / Dihydropteroate synthase (sulfonamide resistance)	Community Requests	1EYE	35.1%	Escherichia coli

IDP01726 (show subtarget assignments)	1	cloned	No	GBAA5252	47530558		D-alanyl-D-alanine carboxypeptidase fami...	279	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	29.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00837 (show subtarget assignments)	1	purified	No	SACOL2735	57285289		chromosome partioning protein, ParB fami...	279	Conserved Gene / Pathway	Phase 2: March 2008	1VZ0	31.2%	Staphylococcus aureus	Cellular processes	Cell division

IDP91294 (show subtarget assignments)	8	soluble	No	SPA4035	56416018		hypothetical protein SPA4035 [Salmonella...	279	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Salmonella enterica

IDP92553 (show subtarget assignments)	8	selected	No	VV1_2233	27361706	fadR	fatty acid metabolism transcriptional re...	279	potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...	Community Requests	1E2X	52%	Vibrio vulnificus

IDP02674 (show subtarget assignments)	1	purified	No	GBAA1562	47777948	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	279	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1M3U	43%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP90546 (show subtarget assignments)	8	in_pdb 3RU6	No	Cj0381c	15791748	pyrF	orotidine 5'-phosphate decarboxylase [Ca...	279	Predicted Essential	Community Requests	3RU6	100%	Campylobacter jejuni

IDP00143 (show subtarget assignments)	1	soluble	No	VC0779	15640798	viuC	vibriobactin and enterobactin ABC transp...	279	Virulence	Phase 1: October 2007	1B0U	29%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01008 (show subtarget assignments)	1	soluble	No	STM2533	16765853	sseA	3-mercaptopyruvate sulfurtransferase	280	Conserved Gene / Pathway	Phase 2: March 2008	1URH	79.6%	Salmonella enterica	Cellular processes	Detoxification

IDP00518 (show subtarget assignments)	1	cloned	No	YPO1566	16121836		putative hydrolase	280	Virulence Associated Factor	Phase 2: March 2008	3QDF	31.8%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00973 (show subtarget assignments)	1	purified	No	STM1756	16765100	purU	formyltetrahydrofolate deformylase	280	Conserved Gene / Pathway	Phase 2: March 2008	3O1L	42.7%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP05669 (show subtarget assignments)	1	expressed	No	lmo0551	16802594	-	hypothetical protein lmo0551 [Listeria m...	280	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Hypothetical proteins: Conserved

IDP00188 (show subtarget assignments)	1	purified	No	YPO0806	16121118	-	prepilin peptidase	280	Virulence	Phase 1: October 2007			Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP01658 (show subtarget assignments)	1	in_crystallization_trials	No	Cj0059c	15791451	fliY	flagellar motor switch protein FliY [Cam...	280	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1O6A	15.4%	Campylobacter jejuni	Cell envelope	Other

IDP00802 (show subtarget assignments)	1	cloned	No	SACOL1704	57284716	mreC	rod shape-determining protein MreC	280	Conserved Gene / Pathway	Phase 2: March 2008	2J5U	29.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90368 (show subtarget assignments)	8	expressed	No	CT_143	3328543		hypothetical protein [Chlamydia trachoma...	280	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP01338 (show subtarget assignments)	1	in_crystallization_trials	No	VC2261	15642259		methionine aminopeptidase	280	Drug Target Function	Community Interest	1MAT	57.5%	Vibrio cholerae	Protein fate	Protein modification and repair

IDP90694 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0840c	15792178	fbp	fructose-1,6-bisphosphatase [Campylobact...	280	Predicted Essential	Community Requests	3IFA	34.9%	Campylobacter jejuni

IDP02420 (show subtarget assignments)	1	expressed	No	YPO1501	16121774		putative esterase [Yersinia pestis CO92]...	280	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	3I6Y	58.9%	Yersinia pestis	Central intermediary metabolism	Other

IDP00309 (show subtarget assignments)	1	expressed	No	CBU_0298	29653649	murI	glutamate racemase	280	Drug Target Function	Phase 2: March 2008	2GZM	38.2%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02378 (show subtarget assignments)	1	cloned	No	CBU_1675	29542234	kdsA	2-dehydro-3-deoxyphosphooctonate aldolas...	280	Conserved; Drug target functions	Phase 3: June 2008	3T4C	62.5%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01163 (show subtarget assignments)	1	purified	No	BA_5526	30259986		ABC transporter, ATP-binding protein	280	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	30%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01154 (show subtarget assignments)	1	expressed	No	BA_0139	56748760		Cobalt import ATP-binding protein cbiO 1...	280	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01153 (show subtarget assignments)	1	cloned	No	BA_5712	30260159		yycI protein	280	Conserved Gene / Pathway	Phase 2: March 2008	2O3O	28.2%	Bacillus anthracis	Cellular processes	Cell division

IDP02261 (show subtarget assignments)	1	expressed	No	GBAA2516	47527804	fba-1	fructose-bisphosphate aldolase [Bacillus...	281	Essential; Drug target functions	Phase 3: June 2008	1RV8	41.2%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP04565 (show subtarget assignments)	1	cloned	No	CPF_1805	110798813		putative lipoprotein [Clostridium perfri...	281	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP05289 (show subtarget assignments)	1	soluble	No	CD0784	126698364		putative N-acetylmuramoyl-L-alanine amid...	281	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02073 (show subtarget assignments)	1	expressed	No	CBU_0418	29541027		4-amino-4-deoxychorismate lyase, putativ...	281	Conserved; Drug target functions	Phase 3: June 2008	3LUL	28.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP90612 (show subtarget assignments)	8	soluble	No	NMPDR 243277.1.peg.3916				281	Predicted Essential	Community Requests	1COZ	17.1%	Vibrio cholerae

IDP00473 (show subtarget assignments)	1	cloned	No	YPO0107	16120454	ftsN	cell division protein FtsN	281	Conserved Gene / Pathway	Phase 2: March 2008	1UTA	15.3%	Yersinia pestis	Cellular processes	Cell division

IDP01680 (show subtarget assignments)	0	work_stopped	No	VC0902	161582018	queF	7-cyano-7-deazaguanine reductase [Vibrio...	281	Conserved; Drug target homolg; Drug target functions	Phase 3: June 2008	3BP1	100%	Vibrio cholerae	N/A	N/A

IDP92247 (show subtarget assignments)	8	selected	No	ABA71730	77380198	vanWG	VanWG [Enterococcus faecalis]	281	drug resistance / Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...	Community Requests			Enterococcus faecalis

IDP00151 (show subtarget assignments)	1	purified	No	VC0403	15640430	mshM	MSHA biogenesis protein MshM	281	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP05101 (show subtarget assignments)	1	in_crystallization_trials	No	CD1058	126698642	hbd	3-hydroxybutyryl-CoA dehydrogenase [Clos...	281	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1F0Y	43.9%	Clostridium difficile	Fatty acid and phospholipid metabolism: Degradation

IDP90211 (show subtarget assignments)	8	cloned	No	MYXV_gp132	9633764	m128L	m128L	281	integrin-associated protein homolog similar to VACV-Cop:A38L. Five pass TM prote...	Community Requests			Myxoma virus	host defense modulator	0

IDP01238 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5635	30260086		lipoate-protein ligase A, putative	281	Drug Target Function	Phase 2: March 2008	2P5I	60.1%	Bacillus anthracis	Protein fate	Protein modification and repair

IDP91051 (show subtarget assignments)	8	in_crystallization_trials	No	PRM0001	81687074	rmtC	16S rRNA methylase [Proteus mirabilis]	281	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3B89	29.2%	Proteus mirabilis

IDP90984 (show subtarget assignments)	8	cloned	No	y0931	22124839		hypothetical protein y0931 [Yersinia pes...	281	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests	3SHO	12.8%	Yersinia pestis

IDP00032 (show subtarget assignments)	1	purified	No	BA_1221	30255171		bacteriocin O-metyltransferase, putative...	281	Virulence	Phase 1: October 2007	2WK1	36.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02340 (show subtarget assignments)	1	soluble	No	GBAA2884	47528179		hypothetical protein GBAA2884 [Bacillus ...	281	Drug target motif; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Hypothetical proteins	Conserved

IDP90810 (show subtarget assignments)	8	in_pdb 3P2O	No	Cj0855	15792193	folD	folD bifunctional protein [Campylobacter...	282	Predicted Essential	Community Requests	3P2O	100%	Campylobacter jejuni

IDP90670 (show subtarget assignments)	8	soluble	No	Cj1202	15792526	metF	5,10-methylenetetrahydrofolate reductase...	282	Predicted Essential	Community Requests	1V93	34%	Campylobacter jejuni

IDP91844 (show subtarget assignments)	8	cloned	No	SAK_1520	76787405		Rgg/GadR/MutR family transcriptional reg...	282	virulence/pathogenesis / Rgg proteins are peptide-ligand-responsive transcription factors that control vi...	Community Requests			Streptococcus agalactiae

IDP00489 (show subtarget assignments)	1	purified	No	YPO1533	16121806		putative iron-siderophore transport syst...	282	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	28.4%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00486 (show subtarget assignments)	1	expressed	No	YPO1463	16121738		putative acyl transferase	282	Conserved Gene / Pathway	Phase 2: March 2008	3RGI	47.2%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01849 (show subtarget assignments)	1	in_pdb 3L07	No	FTT0892	56707993	folD	methylenetetrahydrofolate dehydrogenase/...	282	Conserved; Drug target functions	Phase 3: June 2008	3L07	100%	Francisella tularensis	Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers	Aspartate familyFolic acid

IDP01839 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1563	47526836	panC	pantoate--beta-alanine ligase [Bacillus ...	282	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2X3F	53.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP90800 (show subtarget assignments)	8	in_pdb 3UY4 3MXT	No	Cj0297c	15791665	panC	pantoate--beta-alanine ligase [Campyloba...	282	Predicted Essential	Community Requests	3MXT	100%	Campylobacter jejuni

IDP90141 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_186	68449257		ser/thr protein kinase-like protein [Mon...	282	similar to VACV-COP-B12R, MPXV-ZAI96-B11R	Community Requests	2KTY	32.4%	Monkeypox virus

IDP04439 (show subtarget assignments)	1	cloned	No	YPO0185	115346005	ssiD	putative taurine dioxygenase [Yersinia p...	282	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GQW	75.9%	Yersinia pestis	Energy metabolism	Other

IDP01328 (show subtarget assignments)	1	purified	No	VC0443	15640470	ksgA	dimethyladenosine transferase	282	Conserved Gene / Pathway	Phase 2: March 2008	3TPZ	61.7%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP90884 (show subtarget assignments)	8	in_crystallization_trials	No	VC1296	15641309		phosphomethylpyrimidine kinase [Vibrio c...	282	Predicted Essential	Community Requests	1JXH	43.6%	Vibrio cholerae

IDP91389 (show subtarget assignments)	8	cloned	No	VV1_1437	27364822		Type II secretory pathway, component Exe...	282	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP02387 (show subtarget assignments)	1	expressed	No	FTT1304c	56708362	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	282	Conserved; Drug target functions	Phase 3: June 2008	3TX1	33.7%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02146 (show subtarget assignments)	1	cloned	No	Cj1426c	15792744		hypothetical protein Cj1426c [Campylobac...	283	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Cellular processes	Other

IDP04496 (show subtarget assignments)	1	expressed	No	VC0675	15640694	thyA	thymidylate synthase [Vibrio cholerae O1...	283	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3V8H	35.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP91840 (show subtarget assignments)	8	selected	No	Spy49_0449c	209559004		positive regulator [Streptococcus pyogen...	283	virulence/pathogenesis / Rgg proteins are peptide-ligand-responsive transcription factors that control vi...	Community Requests			Streptococcus pyogenes

IDP90304 (show subtarget assignments)	8	soluble	No	CT_671	3329122		hypothetical protein [Chlamydia trachoma...	283	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP01660 (show subtarget assignments)	1	expressed	No	CBU_0776	29541372		ABC transporter, ATP-binding protein [Co...	283	Conserved; Drug target functions	Phase 3: June 2008	1VPL	25.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01638 (show subtarget assignments)	1	soluble	No	CBU_0312	29540925	folD	folD bifunctional protein [Coxiella burn...	283	Conserved; Drug target functions	Phase 3: June 2008	1B0A	59.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00717 (show subtarget assignments)	1	cloned	No	SACOL1421	57286072		phosphate ABC transporter, ATP-binding p...	283	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	32.9%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP91267 (show subtarget assignments)	8	cloned	No	NT05BA2321	49179114		protein export protein prsA [Bacillus an...	283	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3RFW	25.4%	Bacillus anthracis	Protein fate: Protein folding and stabilization

IDP92056 (show subtarget assignments)	8	selected	No	TGME49_059660	237831725		orotate phosphoribosyltransferase, putat...	283	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1LH0	35.7%	Toxoplasma gondii

IDP01337 (show subtarget assignments)	1	in_pdb 3E9A	No	VC2175	15642174		2-dehydro-3-deoxyphosphooctonate aldolas...	283	Conserved Gene / Pathway	Phase 2: March 2008	3E9A	100%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05305 (show subtarget assignments)	1	cloned	No	CD2986	126700607	bacA2	undecaprenyl pyrophosphate phosphatase [...	283	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02288 (show subtarget assignments)	1	cloned	No	FTT0932	56708030		ROK family protein [Francisella tularens...	283	Drug Target	Phase 3: June 2008	2YHY	29.2%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP05438 (show subtarget assignments)	1	soluble	No	lmo2106	16804145	-	hypothetical protein lmo2106 [Listeria m...	284	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Hypothetical proteins: Conserved

IDP02235 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1105c	56708184	msrA1	bifunctional methionine sulfoxide reduct...	284	Drug Target	Phase 3: June 2008	2GT3	23.2%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein modification and repair

IDP90185 (show subtarget assignments)	0	work_stopped	No	AAM13488.1	20153027	CPXV041 CDS	CPXV041 protein	284	K1L like Host range protein	Community Requests	3KEA	95.1%	Cowpox virus	host defense modulator	0

IDP04145 (show subtarget assignments)	1	expressed	No	YPO3422	115349050	ampE	putative membrane-bound sensory transduc...	284	conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cellular processes	Toxin production and resistance

IDP90121 (show subtarget assignments)	8	purified	No	MPXV_ZAI1979_005_031	68449105		ankyrin-like protein [Monkeypox virus]	284	similar to VACV-COP-K1L, MPXV-ZAI96-C1L	Community Requests	3KEA	94.7%	Monkeypox virus

IDP01793 (show subtarget assignments)	1	in_pdb 3QDN	No	STM0504	16763884	ybbN	putative thioredoxin protein [Salmonella...	284	Conserved; Drug target functions	Phase 3: June 2008	3QDN	100%	Salmonella enterica	Energy metabolism	Electron transport

IDP01774 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3639	16123781		putative glutathione S-transferase YghU ...	284	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3C8E	69%	Yersinia pestis	Central intermediary metabolism	Other

IDP90797 (show subtarget assignments)	8	in_pdb 3MUE	No	STM0181	16763571	panC	pantoate--beta-alanine ligase [Salmonell...	284	Predicted Essential	Community Requests	3MUE	100%	Salmonella enterica

IDP90523 (show subtarget assignments)	8	in_pdb 3Q12 3Q10	No	YPO3402	16123551	panC	pantoate--beta-alanine ligase [Yersinia ...	284	Predicted Essential	Community Requests	3Q10	100%	Yersinia pestis

IDP91970 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100005433	298255040		lipoprotein [Streptococcus pneumoniae st...	284	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1P99	35.6%	Streptococcus pneumoniae

IDP91031 (show subtarget assignments)	8	cloned	No	y4125	22127993		solute-binding periplasmic protein precu...	284	other biological interest / highly abundant periplasmic protein with unknown function	Community Requests	1XT8	31%	Yersinia pestis

IDP91845 (show subtarget assignments)	8	expressed	No	spr0960	15903004	mutR	putative positive transcriptional regula...	284	virulence/pathogenesis / Rgg proteins are peptide-ligand-responsive transcription factors that control vi...	Community Requests			Streptococcus pneumoniae

IDP01195 (show subtarget assignments)	1	in_pdb 3SC6	No	BA_1231	30255180	rfbD	dTDP-4-dehydrorhamnose reductase	284	Drug Target Function	Phase 2: March 2008	3SC6	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04517 (show subtarget assignments)	1	cloned	No	CPF_2840	110799025	ksgA	dimethyladenosine transferase [Clostridi...	285	conserved gene; putative drug target function;	Phase 4: April 2009	3FUT	35.1%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP00995 (show subtarget assignments)	1	in_pdb 3H02	No	STM2307	16765634	menB	naphthoate synthase	285	Conserved Gene / Pathway	Phase 2: March 2008	3H02	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00053 (show subtarget assignments)	1	soluble	No	BA_3536	30258071		phenazine biosynthesis protein, PhzF fam...	285	Virulence	Phase 1: October 2007	1QY9	31.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00926 (show subtarget assignments)	1	soluble	No	STM0597	16763974	entB	2,3-dihydro-2,3-dihydroxybenzoate synthe...	285	Conserved Gene / Pathway	Phase 2: March 2008	2FQ1	88.4%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01865 (show subtarget assignments)	1	in_pdb 3Q94	No	GBAA5580	47530901	fba-2	fructose-bisphosphate aldolase [Bacillus...	285	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3Q94	100%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01659 (show subtarget assignments)	1	crystallized	No	CBU_1739	29542296		tetrapyrrole (Corrin/Porphyrin) methylas...	285	Conserved; Drug target functions	Phase 3: June 2008	3KWP	42.1%	Coxiella burnetii	Unknown function	General

IDP90197 (show subtarget assignments)	8	soluble	No	AAM13645.1	20153184	CPXV206 CDS	CPXV206 protein	285	serine-threonine kinase	Community Requests	2KTY	32.1%	Cowpox virus	Unknown function	0

IDP90366 (show subtarget assignments)	8	expressed	No	CT_142	3328542		hypothetical protein [Chlamydia trachoma...	285	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90367 (show subtarget assignments)	8	expressed	No	CT_144	3328544		hypothetical protein [Chlamydia trachoma...	285	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP91096
(show subtarget assignments)

8

soluble

No

BPSL0876

52208929

kdsB

putative 3-deoxy-manno-octulosonate cyti...

278

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

3K8D

49.6%

Burkholderia pseudomallei

IDP90394
(show subtarget assignments)

8

expressed

No

CT_560

3329001

hypothetical protein [Chlamydia trachoma...

278

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP04547
(show subtarget assignments)

1

cloned

No

CPF_0581

110800184

amino acid ABC transporter, amino acid-b...

278

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PVU

30.2%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP91975
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100009843

298255879

ABC transporter substrate-binding protei...

278

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3HV1

60.1%

Streptococcus pneumoniae

IDP04629
(show subtarget assignments)

1

soluble

No

CBU_0151

29653509

queF

7-cyano-7-deazaguanine reductase [Coxiel...

278

drug target; conserved gene;

Phase 4: April 2009

3BP1

51.4%

Coxiella burnetii

Hypothetical proteins

Conserved

IDP00614
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2109

57286325

modification methylase, HemK family

278

Drug Target Function

Phase 2: March 2008

1T43

32%

Staphylococcus aureus

Unknown function

General

IDP90792
(show subtarget assignments)

8

in_pdb
3PGJ
3O8Q
3SEF

Yes

VC0056

15640088

aroE

shikimate 5-dehydrogenase [Vibrio choler...

278

Predicted Essential

Community Requests

3O8Q

100%

Vibrio cholerae

IDP05596
(show subtarget assignments)

1

cloned

No

BA_3366

30257909

putative lipoprotein [Bacillus anthracis...

278

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP00061
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4399

30258896

hemolysin A

279

Virulence

Phase 1: October 2007

3HP7

58.4%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00565
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0281

16120620

hmuT

hemin-binding periplasmic protein

279

Conserved Gene / Pathway

Phase 2: March 2008

3MD9

91%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP01960
(show subtarget assignments)

1

soluble

No

CBU_0565

29541166

CBS domain protein [Coxiella burnetii RS...

279

Conserved; Drug target functions

Phase 3: June 2008

3LFR

27.2%

Coxiella burnetii

Unknown function

General

IDP04207
(show subtarget assignments)

1

soluble

No

CPF_2836

110801144

putative lipoprotein [Clostridium perfri...

279

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP91777
(show subtarget assignments)

8

purified

No

AAC33914

3513664

sul1

Sul1 dihydropteroate synthase [Escherich...

279

drug resistance / Dihydropteroate synthase (sulfonamide resistance)

Community Requests

1EYE

35.1%

Escherichia coli

IDP01726
(show subtarget assignments)

1

cloned

No

GBAA5252

47530558

D-alanyl-D-alanine carboxypeptidase fami...

279

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

29.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00837
(show subtarget assignments)

1

purified

No

SACOL2735

57285289

chromosome partioning protein, ParB fami...

279

Conserved Gene / Pathway

Phase 2: March 2008

1VZ0

31.2%

Staphylococcus aureus

Cellular processes

Cell division

IDP91294
(show subtarget assignments)

8

soluble

No

SPA4035

56416018

hypothetical protein SPA4035 [Salmonella...

279

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Salmonella enterica

IDP92553
(show subtarget assignments)

8

selected

No

VV1_2233

27361706

fadR

fatty acid metabolism transcriptional re...

279

potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...

Community Requests

1E2X

52%

Vibrio vulnificus

IDP02674
(show subtarget assignments)

1

purified

No

GBAA1562

47777948

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

279

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1M3U

43%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP90546
(show subtarget assignments)

8

in_pdb
3RU6

No

Cj0381c

15791748

pyrF

orotidine 5'-phosphate decarboxylase [Ca...

279

Predicted Essential

Community Requests

3RU6

100%

Campylobacter jejuni

IDP00143
(show subtarget assignments)

1

soluble

No

VC0779

15640798

viuC

vibriobactin and enterobactin ABC transp...

279

Virulence

Phase 1: October 2007

1B0U

29%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01008
(show subtarget assignments)

1

soluble

No

STM2533

16765853

sseA

3-mercaptopyruvate sulfurtransferase

280

Conserved Gene / Pathway

Phase 2: March 2008

1URH

79.6%

Salmonella enterica

Cellular processes

Detoxification

IDP00518
(show subtarget assignments)

1

cloned

No

YPO1566

16121836

putative hydrolase

280

Virulence Associated Factor

Phase 2: March 2008

3QDF

31.8%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00973
(show subtarget assignments)

1

purified

No

STM1756

16765100

purU

formyltetrahydrofolate deformylase

280

Conserved Gene / Pathway

Phase 2: March 2008

3O1L

42.7%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP05669
(show subtarget assignments)

1

expressed

No

lmo0551

16802594

-

hypothetical protein lmo0551 [Listeria m...

280

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP00188
(show subtarget assignments)

1

purified

No

YPO0806

16121118

-

prepilin peptidase

280

Virulence

Phase 1: October 2007

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP01658
(show subtarget assignments)

1

in_crystallization_trials

No

Cj0059c

15791451

fliY

flagellar motor switch protein FliY [Cam...

280

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1O6A

15.4%

Campylobacter jejuni

Cell envelope

Other

IDP00802
(show subtarget assignments)

1

cloned

No

SACOL1704

57284716

mreC

rod shape-determining protein MreC

280

Conserved Gene / Pathway

Phase 2: March 2008

2J5U

29.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90368
(show subtarget assignments)

8

expressed

No

CT_143

3328543

hypothetical protein [Chlamydia trachoma...

280

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP01338
(show subtarget assignments)

1

in_crystallization_trials

No

VC2261

15642259

methionine aminopeptidase

280

Drug Target Function

Community Interest

1MAT

57.5%

Vibrio cholerae

Protein fate

Protein modification and repair

IDP90694
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0840c

15792178

fbp

fructose-1,6-bisphosphatase [Campylobact...

280

Predicted Essential

Community Requests

3IFA

34.9%

Campylobacter jejuni

IDP02420
(show subtarget assignments)

1

expressed

No

YPO1501

16121774

putative esterase [Yersinia pestis CO92]...

280

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

3I6Y

58.9%

Yersinia pestis

Central intermediary metabolism

Other

IDP00309
(show subtarget assignments)

1

expressed

No

CBU_0298

29653649

murI

glutamate racemase

280

Drug Target Function

Phase 2: March 2008

2GZM

38.2%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02378
(show subtarget assignments)

1

cloned

No

CBU_1675

29542234

kdsA

2-dehydro-3-deoxyphosphooctonate aldolas...

280

Conserved; Drug target functions

Phase 3: June 2008

3T4C

62.5%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01163
(show subtarget assignments)

1

purified

No

BA_5526

30259986

ABC transporter, ATP-binding protein

280

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

30%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01154
(show subtarget assignments)

1

expressed

No

BA_0139

56748760

Cobalt import ATP-binding protein cbiO 1...

280

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01153
(show subtarget assignments)

1

cloned

No

BA_5712

30260159

yycI protein

280

Conserved Gene / Pathway

Phase 2: March 2008

2O3O

28.2%

Bacillus anthracis

Cellular processes

Cell division

IDP02261
(show subtarget assignments)

1

expressed

No

GBAA2516

47527804

fba-1

fructose-bisphosphate aldolase [Bacillus...

281

Essential; Drug target functions

Phase 3: June 2008

1RV8

41.2%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP04565
(show subtarget assignments)

1

cloned

No

CPF_1805

110798813

putative lipoprotein [Clostridium perfri...

281

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP05289
(show subtarget assignments)

1

soluble

No

CD0784

126698364

putative N-acetylmuramoyl-L-alanine amid...

281

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02073
(show subtarget assignments)

1

expressed

No

CBU_0418

29541027

4-amino-4-deoxychorismate lyase, putativ...

281

Conserved; Drug target functions

Phase 3: June 2008

3LUL

28.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP90612
(show subtarget assignments)

8

soluble

No

NMPDR 243277.1.peg.3916

281

Predicted Essential

Community Requests

1COZ

17.1%

Vibrio cholerae

IDP00473
(show subtarget assignments)

1

cloned

No

YPO0107

16120454

ftsN

cell division protein FtsN

281

Conserved Gene / Pathway

Phase 2: March 2008

1UTA

15.3%

Yersinia pestis

Cellular processes

Cell division

IDP01680
(show subtarget assignments)

0

work_stopped

No

VC0902

161582018

queF

7-cyano-7-deazaguanine reductase [Vibrio...

281

Conserved; Drug target homolg; Drug target functions

Phase 3: June 2008

3BP1

100%

Vibrio cholerae

N/A

IDP92247
(show subtarget assignments)

8

selected

No

ABA71730

77380198

vanWG

VanWG [Enterococcus faecalis]

281

drug resistance / Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...

Community Requests

Enterococcus faecalis

IDP00151
(show subtarget assignments)

1

purified

No

VC0403

15640430

mshM

MSHA biogenesis protein MshM

281

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP05101
(show subtarget assignments)

1

in_crystallization_trials

No

CD1058

126698642

hbd

3-hydroxybutyryl-CoA dehydrogenase [Clos...

281

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1F0Y

43.9%

Clostridium difficile

Fatty acid and phospholipid metabolism: Degradation

IDP90211
(show subtarget assignments)

8

cloned

No

MYXV_gp132

9633764

m128L

281

integrin-associated protein homolog similar to VACV-Cop:A38L. Five pass TM prote...

Community Requests

Myxoma virus

host defense modulator

0

IDP01238
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5635

30260086

lipoate-protein ligase A, putative

281

Drug Target Function

Phase 2: March 2008

2P5I

60.1%

Bacillus anthracis

Protein fate

Protein modification and repair

IDP91051
(show subtarget assignments)

8

in_crystallization_trials

No

PRM0001

81687074

rmtC

16S rRNA methylase [Proteus mirabilis]

281

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3B89

29.2%

Proteus mirabilis

IDP90984
(show subtarget assignments)

8

cloned

No

y0931

22124839

hypothetical protein y0931 [Yersinia pes...

281

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

3SHO

12.8%

Yersinia pestis

IDP00032
(show subtarget assignments)

1

purified

No

BA_1221

30255171

bacteriocin O-metyltransferase, putative...

281

Virulence

Phase 1: October 2007

2WK1

36.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02340
(show subtarget assignments)

1

soluble

No

GBAA2884

47528179

hypothetical protein GBAA2884 [Bacillus ...

281

Drug target motif; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Hypothetical proteins

Conserved

IDP90810
(show subtarget assignments)

8

in_pdb
3P2O

No

Cj0855

15792193

folD

folD bifunctional protein [Campylobacter...

282

Predicted Essential

Community Requests

3P2O

100%

Campylobacter jejuni

IDP90670
(show subtarget assignments)

8

soluble

No

Cj1202

15792526

metF

5,10-methylenetetrahydrofolate reductase...

282

Predicted Essential

Community Requests

1V93

34%

Campylobacter jejuni

IDP91844
(show subtarget assignments)

8

cloned

No

SAK_1520

76787405

Rgg/GadR/MutR family transcriptional reg...

282

virulence/pathogenesis / Rgg proteins are peptide-ligand-responsive transcription factors that control vi...

Community Requests

Streptococcus agalactiae

IDP00489
(show subtarget assignments)

1

purified

No

YPO1533

16121806

putative iron-siderophore transport syst...

282

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

28.4%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00486
(show subtarget assignments)

1

expressed

No

YPO1463

16121738

putative acyl transferase

282

Conserved Gene / Pathway

Phase 2: March 2008

3RGI

47.2%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01849
(show subtarget assignments)

1

in_pdb
3L07

No

FTT0892

56707993

folD

methylenetetrahydrofolate dehydrogenase/...

282

Conserved; Drug target functions

Phase 3: June 2008

3L07

100%

Francisella tularensis

Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers

Aspartate familyFolic acid

IDP01839
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1563

47526836

panC

pantoate--beta-alanine ligase [Bacillus ...

282

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2X3F

53.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP90800
(show subtarget assignments)

8

in_pdb
3UY4
3MXT

No

Cj0297c

15791665

panC

pantoate--beta-alanine ligase [Campyloba...

282

Predicted Essential

Community Requests

3MXT

100%

Campylobacter jejuni

IDP90141
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_186

68449257

ser/thr protein kinase-like protein [Mon...

282

similar to VACV-COP-B12R, MPXV-ZAI96-B11R

Community Requests

2KTY

32.4%

Monkeypox virus

IDP04439
(show subtarget assignments)

1

cloned

No

YPO0185

115346005

ssiD

putative taurine dioxygenase [Yersinia p...

282

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GQW

75.9%

Yersinia pestis

Energy metabolism

Other

IDP01328
(show subtarget assignments)

1

purified

No

VC0443

15640470

ksgA

dimethyladenosine transferase

282

Conserved Gene / Pathway

Phase 2: March 2008

3TPZ

61.7%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP90884
(show subtarget assignments)

8

in_crystallization_trials

No

VC1296

15641309

phosphomethylpyrimidine kinase [Vibrio c...

282

Predicted Essential

Community Requests

1JXH

43.6%

Vibrio cholerae

IDP91389
(show subtarget assignments)

8

cloned

No

VV1_1437

27364822

Type II secretory pathway, component Exe...

282

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP02387
(show subtarget assignments)

1

expressed

No

FTT1304c

56708362

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

282

Conserved; Drug target functions

Phase 3: June 2008

3TX1

33.7%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02146
(show subtarget assignments)

1

cloned

No

Cj1426c

15792744

hypothetical protein Cj1426c [Campylobac...

283

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Cellular processes

Other

IDP04496
(show subtarget assignments)

1

expressed

No

VC0675

15640694

thyA

thymidylate synthase [Vibrio cholerae O1...

283

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3V8H

35.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP91840
(show subtarget assignments)

8

selected

No

Spy49_0449c

209559004

positive regulator [Streptococcus pyogen...

283

virulence/pathogenesis / Rgg proteins are peptide-ligand-responsive transcription factors that control vi...

Community Requests

Streptococcus pyogenes

IDP90304
(show subtarget assignments)

8

soluble

No

CT_671

3329122

hypothetical protein [Chlamydia trachoma...

283

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP01660
(show subtarget assignments)

1

expressed

No

CBU_0776

29541372

ABC transporter, ATP-binding protein [Co...

283

Conserved; Drug target functions

Phase 3: June 2008

1VPL

25.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01638
(show subtarget assignments)

1

soluble

No

CBU_0312

29540925

folD

folD bifunctional protein [Coxiella burn...

283

Conserved; Drug target functions

Phase 3: June 2008

1B0A

59.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00717
(show subtarget assignments)

1

cloned

No

SACOL1421

57286072

phosphate ABC transporter, ATP-binding p...

283

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

32.9%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP91267
(show subtarget assignments)

8

cloned

No

NT05BA2321

49179114

protein export protein prsA [Bacillus an...

283

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3RFW

25.4%

Bacillus anthracis

Protein fate: Protein folding and stabilization

IDP92056
(show subtarget assignments)

8

selected

No

TGME49_059660

237831725

orotate phosphoribosyltransferase, putat...

283

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1LH0

35.7%

Toxoplasma gondii

IDP01337
(show subtarget assignments)

1

in_pdb
3E9A

No

VC2175

15642174

2-dehydro-3-deoxyphosphooctonate aldolas...

283

Conserved Gene / Pathway

Phase 2: March 2008

3E9A

100%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05305
(show subtarget assignments)

1

cloned

No

CD2986

126700607

bacA2

undecaprenyl pyrophosphate phosphatase [...

283

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02288
(show subtarget assignments)

1

cloned

No

FTT0932

56708030

ROK family protein [Francisella tularens...

283

Drug Target

Phase 3: June 2008

2YHY

29.2%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP05438
(show subtarget assignments)

1

soluble

No

lmo2106

16804145

-

hypothetical protein lmo2106 [Listeria m...

284

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP02235
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1105c

56708184

msrA1

bifunctional methionine sulfoxide reduct...

284

Drug Target

Phase 3: June 2008

2GT3

23.2%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein modification and repair

IDP90185
(show subtarget assignments)

0

work_stopped

No

AAM13488.1

20153027

CPXV041 CDS

CPXV041 protein

284

K1L like Host range protein

Community Requests

3KEA

95.1%

Cowpox virus

host defense modulator

0

IDP04145
(show subtarget assignments)

1

expressed

No

YPO3422

115349050

ampE

putative membrane-bound sensory transduc...

284

conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP90121
(show subtarget assignments)

8

purified

No

MPXV_ZAI1979_005_031

68449105

ankyrin-like protein [Monkeypox virus]

284

similar to VACV-COP-K1L, MPXV-ZAI96-C1L

Community Requests

3KEA

94.7%

Monkeypox virus

IDP01793
(show subtarget assignments)

1

in_pdb
3QDN

No

STM0504

16763884

ybbN

putative thioredoxin protein [Salmonella...

284

Conserved; Drug target functions

Phase 3: June 2008

3QDN

100%

Salmonella enterica

Energy metabolism

Electron transport

IDP01774
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3639

16123781

putative glutathione S-transferase YghU ...

284

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3C8E

69%

Yersinia pestis

Central intermediary metabolism

Other

IDP90797
(show subtarget assignments)

8

in_pdb
3MUE

No

STM0181

16763571

panC

pantoate--beta-alanine ligase [Salmonell...

284

Predicted Essential

Community Requests

3MUE

100%

Salmonella enterica

IDP90523
(show subtarget assignments)

8

in_pdb
3Q12
3Q10

No

YPO3402

16123551

panC

pantoate--beta-alanine ligase [Yersinia ...

284

Predicted Essential

Community Requests

3Q10

100%

Yersinia pestis

IDP91970
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100005433

298255040

lipoprotein [Streptococcus pneumoniae st...

284

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1P99

35.6%

Streptococcus pneumoniae

IDP91031
(show subtarget assignments)

8

cloned

No

y4125

22127993

solute-binding periplasmic protein precu...

284

other biological interest / highly abundant periplasmic protein with unknown function

Community Requests

1XT8

31%

Yersinia pestis

IDP91845
(show subtarget assignments)

8

expressed

No

spr0960

15903004

mutR

putative positive transcriptional regula...

284

virulence/pathogenesis / Rgg proteins are peptide-ligand-responsive transcription factors that control vi...

Community Requests

Streptococcus pneumoniae

IDP01195
(show subtarget assignments)

1

in_pdb
3SC6

No

BA_1231

30255180

rfbD

dTDP-4-dehydrorhamnose reductase

284

Drug Target Function

Phase 2: March 2008

3SC6

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04517
(show subtarget assignments)

1

cloned

No

CPF_2840

110799025

ksgA

dimethyladenosine transferase [Clostridi...

285

conserved gene; putative drug target function;

Phase 4: April 2009

3FUT

35.1%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP00995
(show subtarget assignments)

1

in_pdb
3H02

No

STM2307

16765634

menB

naphthoate synthase

285

Conserved Gene / Pathway

Phase 2: March 2008

3H02

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00053
(show subtarget assignments)

1

soluble

No

BA_3536

30258071

phenazine biosynthesis protein, PhzF fam...

285

Virulence

Phase 1: October 2007

1QY9

31.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00926
(show subtarget assignments)

1

soluble

No

STM0597

16763974

entB

2,3-dihydro-2,3-dihydroxybenzoate synthe...

285

Conserved Gene / Pathway

Phase 2: March 2008

2FQ1

88.4%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01865
(show subtarget assignments)

1

in_pdb
3Q94

No

GBAA5580

47530901

fba-2

fructose-bisphosphate aldolase [Bacillus...

285

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3Q94

100%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01659
(show subtarget assignments)

1

crystallized

No

CBU_1739

29542296

tetrapyrrole (Corrin/Porphyrin) methylas...

285

Conserved; Drug target functions

Phase 3: June 2008

3KWP

42.1%

Coxiella burnetii

Unknown function

General

IDP90197
(show subtarget assignments)

8

soluble

No

AAM13645.1

20153184

CPXV206 CDS

CPXV206 protein

285

serine-threonine kinase

Community Requests

2KTY

32.1%

Cowpox virus

Unknown function

0

IDP90366
(show subtarget assignments)

8

expressed

No

CT_142

3328542

hypothetical protein [Chlamydia trachoma...

285

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90367
(show subtarget assignments)

8

expressed

No

CT_144

3328544

hypothetical protein [Chlamydia trachoma...

285

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis