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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 24 of 60, showing 100 records out of 5973 total, starting on record 2301
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP01737
(
show subtarget assignments
)
1
soluble
No
STM3690
16766975
putative inner membrane lipoprotein [Sal...
227
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP00452
(
show subtarget assignments
)
1
purified
No
YPO2245
16122473
electron transport complex protein RnfB ...
188
Conserved Gene / Pathway
Phase 2: March 2008
1GT8
14.4%
Yersinia pestis
Unknown function
General
IDP01722
(
show subtarget assignments
)
1
soluble
No
STM1881
16765223
yebF
hypothetical protein STM1881 [Salmonella...
117
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP00093
(
show subtarget assignments
)
1
expressed
No
NT01SF0510
30040252
ybbF
hypothetical protein S0463
240
Essential
Phase 1: October 2007
Shigella flexneri
Unknown function
General
IDP00842
(
show subtarget assignments
)
1
purified
No
SACOL1186
57284471
antibacterial protein (phenol soluble mo...
44
Drug Target Function
Phase 2: March 2008
Staphylococcus aureus
Unknown function
General
IDP00840
(
show subtarget assignments
)
1
purified
No
SACOL1894
57284813
HIT family protein
140
Drug Target Function
Phase 2: March 2008
1Y23
52.1%
Staphylococcus aureus
Unknown function
General
IDP01706
(
show subtarget assignments
)
1
cloned
No
STM1438
16764786
ydhL
putative oxidoreductase [Salmonella typh...
79
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP04114
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1611
115347358
conserved hypothetical protein [Yersinia...
117
drug target; conserved gene;
Phase 4: April 2009
3N1S
84.6%
Yersinia pestis
Unknown function
General
IDP02675
(
show subtarget assignments
)
1
expressed
No
CBU_1842
29542398
GTP-binding protein YchF [Coxiella burne...
363
Conserved; Drug target functions
Phase 3: June 2008
1JAL
65.3%
Coxiella burnetii
Unknown function
General
IDP00443
(
show subtarget assignments
)
1
soluble
No
YPO0908
16121213
visC
hypothetical protein YPO0908
406
Drug Target Function
Phase 2: March 2008
2R0C
24.3%
Yersinia pestis
Unknown function
General
IDP01681
(
show subtarget assignments
)
1
cloned
No
GBAA4795
47530092
hypothetical protein GBAA4795 [Bacillus ...
572
Conserved; Essential; Involved in sporulation;
Phase 3: June 2008
3AU2
37.1%
Bacillus anthracis
Unknown function
General
IDP01668
(
show subtarget assignments
)
1
soluble
No
GBAA0060
47525314
hypothetical protein GBAA0060 [Bacillus ...
160
Essential;
Phase 3: June 2008
2K4K
29.4%
Bacillus anthracis
Unknown function
General
IDP02819
(
show subtarget assignments
)
1
expressed
No
STM2414
16765738
yfeD
putative negative regulator [Salmonella ...
130
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP01659
(
show subtarget assignments
)
1
crystallized
No
CBU_1739
29542296
tetrapyrrole (Corrin/Porphyrin) methylas...
285
Conserved; Drug target functions
Phase 3: June 2008
3KWP
42.1%
Coxiella burnetii
Unknown function
General
IDP01649
(
show subtarget assignments
)
1
expressed
No
CBU_0796
29541390
HIT family protein [Coxiella burnetii RS...
113
Conserved; Drug target functions
Phase 3: June 2008
1AV5
49.6%
Coxiella burnetii
Unknown function
General
IDP00179
(
show subtarget assignments
)
1
cloned
No
YPO0277
16120616
-
putative transmembrane transport protein...
428
Similar to Essential SALTY
Phase 1: October 2007
Yersinia pestis
Unknown function
General
IDP01622
(
show subtarget assignments
)
1
cloned
No
STM4396
16767642
ytfB
putative cell envelope opacity-associate...
211
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP01621
(
show subtarget assignments
)
1
cloned
No
STM1984
16765321
yodD
putative cytoplasmic protein [Salmonella...
75
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP00174
(
show subtarget assignments
)
1
cloned
No
YPO1140
16121437
-
putative membrane protein
272
Similar to Essential SALTY
Phase 1: October 2007
Yersinia pestis
Unknown function
General
IDP00173
(
show subtarget assignments
)
1
cloned
No
YPO2922
16123109
-
putative membrane protein
486
Virulence
Phase 1: October 2007
3K4U
14.4%
Yersinia pestis
Unknown function
General
IDP02811
(
show subtarget assignments
)
1
soluble
No
STM1880
16765222
yebE
putative inner membrane protein [Salmone...
219
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP00764
(
show subtarget assignments
)
1
expressed
No
SACOL0447
57286820
phosphoglycerate mutase family protein
193
Drug Target Function
Phase 2: March 2008
1C7Z
31.1%
Staphylococcus aureus
Unknown function
General
IDP02808
(
show subtarget assignments
)
1
cloned
No
STM1084
16764443
yccK
sulfurtransferase TusE [Salmonella typhi...
109
Conserved; Drug target functions
Phase 3: June 2008
1YX3
47.7%
Salmonella enterica
Unknown function
General
IDP00747
(
show subtarget assignments
)
0
work_stopped
No
SACOL1768
57286203
GAF domain protein
154
Drug Target Function
Phase 2: March 2008
3KSF
98.7%
Staphylococcus aureus
Unknown function
General
IDP00081
(
show subtarget assignments
)
1
in_crystallization_trials
No
NT01ST5473
16422973
ytfP
putative cytoplasmic protein
114
Essential
Phase 1: October 2007
1XHS
92.1%
Salmonella enterica
Unknown function
General
IDP02658
(
show subtarget assignments
)
1
cloned
No
STM2648
16765968
yfiF
putative methyltransferase [Salmonella t...
345
Conserved; Essential; Drug target functions
Phase 3: June 2008
1X7O
20.6%
Salmonella enterica
Unknown function
General
IDP00401
(
show subtarget assignments
)
1
cloned
No
YPO2490
161486873
putative hemolysin
2531
Virulence Associated Factor
Phase 2: March 2008
1RWR
3.9%
Yersinia pestis
Viral functions
General
IDP00679
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL1699
57284711
obgE
GTPase ObgE
430
Drug Target Function
Phase 2: March 2008
1LNZ
54.2%
Staphylococcus aureus
Unknown function
General
IDP02609
(
show subtarget assignments
)
1
in_pdb
3LQN
Yes
GBAA4196
47529491
CBS domain-containing protein [Bacillus ...
147
Drug target motif;
Phase 3: June 2008
3LQN
100%
Bacillus anthracis
Unknown function
General
IDP02600
(
show subtarget assignments
)
1
expressed
No
STM2279
16765606
yfaE
2Fe-2S ferredoxin YfaE [Salmonella typhi...
84
Conserved; Drug target functions
Phase 3: June 2008
1IUE
37.2%
Salmonella enterica
Unknown function
General
IDP04110
(
show subtarget assignments
)
1
expressed
No
YPO2440
218929529
yfeB
ATP-binding transport protein [Yersinia ...
296
virulence factor; conserved gene;
Phase 4: April 2009
3GFO
26.4%
Yersinia pestis
Unknown function
General
IDP02587
(
show subtarget assignments
)
1
cloned
No
STM2571
16765891
murQ
N-acetylmuramic acid-6-phosphate etheras...
297
Conserved; Drug target functions
Phase 3: June 2008
1NRI
51.9%
Salmonella enterica
Unknown function
General
IDP02584
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1301
16764652
pyrimidine (deoxy)nucleoside triphosphat...
138
Conserved; Drug target functions
Phase 3: June 2008
2RRK
75.4%
Salmonella enterica
Unknown function
General
IDP02578
(
show subtarget assignments
)
1
expressed
No
STM0262
16763645
yafS
putative SAM-dependent methyltransferase...
240
Conserved; Drug target functions
Phase 3: June 2008
1VLM
11.7%
Salmonella enterica
Unknown function
General
IDP00071
(
show subtarget assignments
)
0
work_stopped
No
NT01ST2260
16420352
yeaZ
putative molecular chaperone
231
Essential
Phase 1: October 2007
2GEL
100%
Salmonella enterica
Unknown function
General
IDP04710
(
show subtarget assignments
)
1
selected
No
YPO0510
115346319
hypothetical protein [Yersinia pestis CO...
367
virulence factor; conserved gene;
Phase 4: April 2009
2XT2
14.7%
Yersinia pestis
Unknown function
General
IDP02509
(
show subtarget assignments
)
1
crystallized
No
STM1809
16765150
putative cytoplasmic protein [Salmonella...
57
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP02715
(
show subtarget assignments
)
1
cloned
No
STM3573
16766859
yhhL
hypothetical protein STM3573 [Salmonella...
90
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP00644
(
show subtarget assignments
)
1
expressed
No
SACOL0220
57286684
flavohemoprotein, putative
381
Conserved Gene / Pathway
Phase 2: March 2008
1CQX
36.9%
Staphylococcus aureus
Unknown function
General
IDP00640
(
show subtarget assignments
)
1
in_pdb
3EME
3MZZ
No
SACOL1807
57286241
rhodanese-like domain protein
103
Drug Target Function
Phase 2: March 2008
3EME
100%
Staphylococcus aureus
Unknown function
General
IDP02784
(
show subtarget assignments
)
1
expressed
No
PSLT072
17233503
putative transglycosylase [Salmonella ty...
156
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP00638
(
show subtarget assignments
)
1
purified
No
SACOL2736
57285290
gidB
glucose-inhibited division protein B
239
Drug Target Function
Phase 2: March 2008
1XDZ
63.2%
Staphylococcus aureus
Unknown function
General
IDP02451
(
show subtarget assignments
)
1
in_pdb
3IMI
No
GBAA1047
47526323
HIT family protein [Bacillus anthracis s...
144
Drug target motif; Involved in sporulation;
Phase 3: June 2008
3IMI
100%
Bacillus anthracis
Unknown function
General
IDP00636
(
show subtarget assignments
)
1
cloned
No
SACOL1118
57285904
typA
GTP-binding protein TypA
615
Drug Target Function
Phase 2: March 2008
3E3X
27.6%
Staphylococcus aureus
Unknown function
General
IDP04348
(
show subtarget assignments
)
1
cloned
No
CPF_2547
110801206
two component regulator [Clostridium per...
686
viruelnce factor;
Phase 4: April 2009
Clostridium perfringens
Unknown function
General
IDP02430
(
show subtarget assignments
)
1
expressed
No
FTT1151c
56708222
hypothetical protein FTT1151c [Francisel...
95
Drug Target
Phase 3: June 2008
2JR5
25.3%
Francisella tularensis
Unknown function
General
IDP00139
(
show subtarget assignments
)
1
crystallized
No
BA_4355
30258855
argC
N-acetyl-gamma-glutamyl-phosphate reduct...
345
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
1VKN
40.5%
Bacillus anthracis
Unknown function
General
IDP02375
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA4701
47530000
engB
GTPase EngB [Bacillus anthracis str. 'Am...
198
Conserved; Essential;
Phase 3: June 2008
1SUL
72.2%
Bacillus anthracis
Unknown function
General
IDP00614
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL2109
57286325
modification methylase, HemK family
278
Drug Target Function
Phase 2: March 2008
1T43
32%
Staphylococcus aureus
Unknown function
General
IDP02707
(
show subtarget assignments
)
1
cloned
No
STM3237
16766536
yhaL
putative cytoplasmic protein [Salmonella...
54
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP02628
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM2923
16766229
putative cytoplasmic protein [Salmonella...
78
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP00606
(
show subtarget assignments
)
1
cloned
No
SACOL1933
57286280
ThiJ/PfpI family protein
171
Drug Target Function
Phase 2: March 2008
1OI4
48.8%
Staphylococcus aureus
Unknown function
General
IDP02303
(
show subtarget assignments
)
1
cloned
No
FTT0530c
56707664
DJ-1/PfpI family protein [Francisella tu...
200
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
3MGK
50.5%
Francisella tularensis
Unknown function
General
IDP02294
(
show subtarget assignments
)
1
cloned
No
FTT0483c
56707625
hypothetical protein FTT0483c [Francisel...
295
Drug Target
Phase 3: June 2008
2YKR
39.7%
Francisella tularensis
Unknown function
General
IDP02290
(
show subtarget assignments
)
1
expressed
No
GBAA3674
47528959
ahpC/TSA family protein [Bacillus anthra...
191
Drug target motif; Involved in sporulation;
Phase 3: June 2008
1ST9
29.8%
Bacillus anthracis
Unknown function
General
IDP04446
(
show subtarget assignments
)
1
cloned
No
YPO0653
115346457
glnE
glutamate-ammonia-ligase adenylyltransfe...
951
conserved gene; putative drug target function;
Phase 4: April 2009
3K7D
38.5%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP01087
(
show subtarget assignments
)
1
cloned
No
STM4465
16767710
ornithine carbamoyltransferase
334
Conserved Gene / Pathway
Phase 2: March 2008
3UPD
75.7%
Salmonella enterica
Amino acid biosynthesis
Glutamate family
IDP01077
(
show subtarget assignments
)
0
work_stopped
No
STM4122
161353577
argB
acetylglutamate kinase
257
Conserved Gene / Pathway
Phase 2: March 2008
1GS5
94.2%
Salmonella enterica
Amino acid biosynthesis
Glutamate family
IDP01076
(
show subtarget assignments
)
8
expressed
No
STM4120
16767385
argE
acetylornithine deacetylase
383
Drug Target Function
Community Requests
3CT9
25.1%
Salmonella enterica
Amino acid biosynthesis
Glutamate family
IDP02179
(
show subtarget assignments
)
1
soluble
No
CBU_2090
29542640
proC
pyrroline-5-carboxylate reductase [Coxie...
274
Conserved; Drug target functions
Phase 3: June 2008
3TRI
100%
Coxiella burnetii
Amino acid biosynthesis
Glutamate family
IDP02736
(
show subtarget assignments
)
1
cloned
No
GBAA4352
47778283
argD
acetylornithine aminotransferase [Bacill...
386
Conserved; Essential; Drug target functions
Phase 3: June 2008
2E54
44%
Bacillus anthracis
Amino acid biosynthesis
Glutamate family
IDP04174
(
show subtarget assignments
)
1
diffraction
No
VC2508
15642504
ornithine carbamoyltransferase [Vibrio c...
334
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3UPD
82.6%
Vibrio cholerae
Amino acid biosynthesis
Glutamate family
IDP02102
(
show subtarget assignments
)
1
cloned
No
CBU_0503
29541108
glnA
glutamine synthetase [Coxiella burnetii ...
359
Conserved; Drug target functions
Phase 3: June 2008
3FKY
49.9%
Coxiella burnetii
Amino acid biosynthesis
Glutamate family
IDP02086
(
show subtarget assignments
)
1
cloned
No
YPO3557
161486860
gltB
glutamate synthase subunit alpha [Yersin...
1538
Conserved; CD; Involved in virulence; Drug target functions
Phase 3: June 2008
1EA0
45%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP00537
(
show subtarget assignments
)
1
purified
No
YPO3924
16124055
argH
argininosuccinate lyase
457
Conserved Gene / Pathway
Phase 2: March 2008
1TJ7
88.8%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP00519
(
show subtarget assignments
)
1
cloned
No
YPO3446
16123594
argI
ornithine carbamoyltransferase subunit I...
335
Conserved Gene / Pathway
Phase 2: March 2008
1AKM
79.1%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP00959
(
show subtarget assignments
)
1
soluble
No
STM1303
16764654
argD
bifunctional succinylornithine transamin...
408
Conserved Gene / Pathway
Phase 2: March 2008
2PB0
60.8%
Salmonella enterica
Amino acid biosynthesis
Glutamate family
IDP00107
(
show subtarget assignments
)
1
in_pdb
3DR3
No
NT01SF4834
30043015
argC
N-acetyl-gamma-glutamylphosphate reducta...
334
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3DR3
100%
Shigella flexneri
Amino acid biosynthesis
Glutamate family
IDP04413
(
show subtarget assignments
)
1
cloned
No
VC2373
15642370
glutamate synthase, large subunit [Vibri...
1530
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1LLW
44.6%
Vibrio cholerae
Amino acid biosynthesis
Glutamate family
IDP00481
(
show subtarget assignments
)
1
expressed
No
YPO3558
16123702
gltD
glutamate synthase subunit beta
472
Virulence Associated Factor
Phase 2: March 2008
2VDC
43.2%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP02718
(
show subtarget assignments
)
1
cloned
No
GBAA3833
47529118
glnA
glutamine synthetase, type I [Bacillus a...
444
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3QAJ
86.7%
Bacillus anthracis
Amino acid biosynthesis
Glutamate family
IDP00444
(
show subtarget assignments
)
1
cloned
No
YPO0342
16120677
putative oxidoreductase Fe-S binding sub...
671
Drug Target Function
Phase 2: March 2008
2VDC
28.8%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP04437
(
show subtarget assignments
)
1
cloned
No
YPO0023
115345855
glnR
Two component regulatory protein involve...
349
putative drug target function;
Phase 4: April 2009
1R62
38.4%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP02815
(
show subtarget assignments
)
1
soluble
No
GBAA4880
47530173
argG
argininosuccinate synthase [Bacillus ant...
401
Conserved; Drug target functions
Phase 3: June 2008
1VL2
46.7%
Bacillus anthracis
Amino acid biosynthesis
Glutamate family
IDP02670
(
show subtarget assignments
)
1
cloned
No
GBAA4353
47529649
argB
acetylglutamate kinase [Bacillus anthrac...
255
Conserved; Drug target functions
Phase 3: June 2008
2BTY
43.1%
Bacillus anthracis
Amino acid biosynthesis
Glutamate family
IDP01627
(
show subtarget assignments
)
1
cloned
No
GBAA0530
50196914
glutamate synthase, large subunit, putat...
1478
Conserved; Drug target functions
Phase 3: June 2008
1EA0
29.7%
Bacillus anthracis
Amino acid biosynthesis
Glutamate family
IDP04429
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA4879
47530172
argH-2
argininosuccinate lyase [Bacillus anthra...
462
conserved gene; putative drug target function;
Phase 4: April 2009
2E9F
48.3%
Bacillus anthracis
Amino acid biosynthesis
Glutamate family
IDP02649
(
show subtarget assignments
)
1
purified
No
STM1795
16765136
putative glutamic dehyrogenase-like prot...
441
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
3AOE
58.5%
Salmonella enterica
Amino acid biosynthesis
Glutamate family
IDP02525
(
show subtarget assignments
)
1
in_pdb
4EP1
No
GBAA4351
47529646
argF
ornithine carbamoyltransferase [Bacillus...
316
Conserved; Drug target functions
Phase 3: June 2008
4EP1
99.7%
Bacillus anthracis
Amino acid biosynthesis
Glutamate family
IDP02492
(
show subtarget assignments
)
1
crystallized
No
FTT1559c
56708586
proC
pyrroline-5-carboxylate reductase [Franc...
274
Conserved; Drug target functions
Phase 3: June 2008
3TRI
37.6%
Francisella tularensis
Amino acid biosynthesis
Glutamate family
IDP00068
(
show subtarget assignments
)
0
work_stopped
No
NT01ST0271
16418722
pyrH
uridylate kinase
241
Essential
Phase 1: October 2007
2BNE
97.9%
Salmonella enterica
Amino acid biosynthesis
Glutamate family
IDP02396
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA3604
47528890
argH-1
argininosuccinate lyase [Bacillus anthra...
502
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
2E9F
27.5%
Bacillus anthracis
Amino acid biosynthesis
Glutamate family
IDP02337
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA1511
47526786
gdhA
glutamate dehydrogenase [Bacillus anthra...
428
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3K8Z
84.1%
Bacillus anthracis
Amino acid biosynthesis
Glutamate family
IDP01063
(
show subtarget assignments
)
1
soluble
No
STM3702
16766987
grxC
glutaredoxin 3
83
Conserved Gene / Pathway
Phase 2: March 2008
1FOV
86.7%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Glutathione and analogs
IDP01828
(
show subtarget assignments
)
1
in_pdb
3NZT
Yes
FTT0367c
56707518
gshA
glutamate--cysteine ligase [Francisella ...
501
Drug Target
Phase 3: June 2008
3NZT
100%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Glutathione and analogs
IDP00895
(
show subtarget assignments
)
1
in_pdb
3IR4
Yes
STM1165
16764521
grxB
glutaredoxin 2
215
Conserved Gene / Pathway
Phase 2: March 2008
3IR4
100%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Glutathione and analogs
IDP02752
(
show subtarget assignments
)
1
crystallized
No
FTT0650c
56707772
grxB
glutaredoxin 2 [Francisella tularensis s...
214
Drug Target
Phase 3: June 2008
3IR4
30.4%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Glutathione and analogs
IDP04545
(
show subtarget assignments
)
1
purified
No
CPF_1198
110801283
glutathione peroxidase [Clostridium perf...
178
drug target; putative drug target function;
Phase 4: April 2009
3CMI
48.3%
Clostridium perfringens
Biosynthesis of cofactors, prosthetic groups, and carriers
Glutathione and analogs
IDP02261
(
show subtarget assignments
)
1
expressed
No
GBAA2516
47527804
fba-1
fructose-bisphosphate aldolase [Bacillus...
281
Essential; Drug target functions
Phase 3: June 2008
1RV8
41.2%
Bacillus anthracis
Energy metabolism
Glycolysis/gluconeogenesis
IDP02760
(
show subtarget assignments
)
1
in_pdb
4EHJ
No
FTT1367c
56708420
pgk
phosphogylcerate kinase [Francisella tul...
392
Conserved; Drug target functions
Phase 3: June 2008
4EHJ
100%
Francisella tularensis
Energy metabolism
Glycolysis/gluconeogenesis
IDP02733
(
show subtarget assignments
)
1
in_pdb
3M5P
3Q7I
3Q88
3LJK
Yes
FTT1315c
56708372
pgi
glucose-6-phosphate isomerase [Francisel...
540
Conserved; Drug target functions
Phase 3: June 2008
3LJK
99.8%
Francisella tularensis
Energy metabolism
Glycolysis/gluconeogenesis
IDP02082
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0080
56707259
tpiA
triosephosphate isomerase [Francisella t...
253
Conserved; Drug target functions
Phase 3: June 2008
1TMH
42.7%
Francisella tularensis
Energy metabolism
Glycolysis/gluconeogenesis
IDP01986
(
show subtarget assignments
)
1
soluble
No
YPO0138
16120481
pckA
phosphoenolpyruvate carboxykinase [Yersi...
539
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1AQ2
87.2%
Yersinia pestis
Energy metabolism
Glycolysis/gluconeogenesis
IDP01950
(
show subtarget assignments
)
1
expressed
No
STM1939
16765280
putative glucose-6-phosphate dehydrogena...
108
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Energy metabolism
Glycolysis/gluconeogenesis
IDP01865
(
show subtarget assignments
)
1
in_pdb
3Q94
No
GBAA5580
47530901
fba-2
fructose-bisphosphate aldolase [Bacillus...
285
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3Q94
100%
Bacillus anthracis
Energy metabolism
Glycolysis/gluconeogenesis
IDP00200
(
show subtarget assignments
)
1
expressed
No
YPO1473
16121748
-
hypothetical protein
766
Virulence
Phase 1: October 2007
Yersinia pestis
Energy metabolism
Glycolysis/gluconeogenesis
IDP02688
(
show subtarget assignments
)
0
work_stopped
No
YPO0921
16121226
pgk
phosphoglycerate kinase [Yersinia pestis...
387
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1ZMR
88.6%
Yersinia pestis
Energy metabolism
Glycolysis/gluconeogenesis
IDP02755
(
show subtarget assignments
)
1
expressed
No
FTT1365c
56708418
fbaB
fructose-1,6-bisphosphate aldolase [Fran...
354
Conserved; Drug target functions
Phase 3: June 2008
3GAK
46.6%
Francisella tularensis
Energy metabolism
Glycolysis/gluconeogenesis
IDP01650
(
show subtarget assignments
)
1
in_pdb
3IFS
No
GBAA5130
47530435
pgi
glucose-6-phosphate isomerase [Bacillus ...
450
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3IFS
100%
Bacillus anthracis
Energy metabolism
Glycolysis/gluconeogenesis
IDP01635
(
show subtarget assignments
)
1
soluble
No
GBAA4844
47530139
pfkA
6-phosphofructokinase [Bacillus anthraci...
319
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3U39
86.5%
Bacillus anthracis
Energy metabolism
Glycolysis/gluconeogenesis
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