Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02526 (show subtarget assignments)	1	cloned	No	FTT1600c	56708620	fumA	fumerate hydratase [Francisella tularens...	504	Drug Target	Phase 3: June 2008	2ISB	13.7%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02520 (show subtarget assignments)	1	soluble	No	FTT0833	56707942	ispH	IspH protein [Francisella tularensis sub...	318	Drug Target	Phase 3: June 2008	3F7T	51.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02485 (show subtarget assignments)	1	cloned	No	FTT1539c	56708571		hypothetical protein FTT1539c [Francisel...	476	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP02457 (show subtarget assignments)	1	expressed	No	FTT1248	56708310		ABC transporter, ATP-binding protein [Fr...	253	Drug Target	Phase 3: June 2008	1B0U	31.1%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02450 (show subtarget assignments)	1	expressed	No	FTT1475	56708515	galT	galactose-1-phosphate uridylyltransferas...	341	Drug Target	Phase 3: June 2008	1HXQ	51.6%	Francisella tularensis	Energy metabolism	Sugars

IDP02448 (show subtarget assignments)	1	in_pdb 3KD3	No	FTT0568	56707697		hypothetical protein FTT0568 [Francisell...	216	Drug Target	Phase 3: June 2008	3KD3	100%	Francisella tularensis	Amino acid biosynthesis	Serine family

IDP02441 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1478c	56708518	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	250	Drug Target	Phase 3: June 2008	3TQD	51.2%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02437 (show subtarget assignments)	1	expressed	No	FTT1226c	56708288	iscS	cysteine desulfarase [Francisella tulare...	391	Drug Target	Phase 3: June 2008	1P3W	41.9%	Francisella tularensis	Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers	Pyruvate familyOther

IDP02434 (show subtarget assignments)	1	soluble	No	FTT1241	56708303	glyA	serine hydroxymethyltransferase [Francis...	417	Drug Target	Phase 3: June 2008	3GBX	67.1%	Francisella tularensis	Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin	Serine familyFolic acid,Purine ribonucleotide biosynthesis

IDP02430 (show subtarget assignments)	1	expressed	No	FTT1151c	56708222		hypothetical protein FTT1151c [Francisel...	95	Drug Target	Phase 3: June 2008	2JR5	25.3%	Francisella tularensis	Unknown function	General

IDP02423 (show subtarget assignments)	1	cloned	No	FTT1138	56708213	hemH	ferrochelatase [Francisella tularensis s...	333	Drug Target	Phase 3: June 2008	1HRK	27.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02405 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1803c	56708789	trpR	trp operon repressor [Francisella tulare...	95	Drug Target	Phase 3: June 2008	1CO0	30.5%	Francisella tularensis	Amino acid biosynthesisRegulatory functions	Aromatic amino acid familyDNA interactions

IDP02402 (show subtarget assignments)	1	purified	No	FTT1778c	56708771		hypothetical protein FTT1778c [Francisel...	130	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP02397 (show subtarget assignments)	1	purified	No	FTT1326	56708383	udp	uridine phosphorylase [Francisella tular...	267	Drug Target	Phase 3: June 2008	3O6V	43.1%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02391 (show subtarget assignments)	1	cloned	No	FTT0534c	56707667	nrdA	ribonucleotide-diphosphate reductase sub...	590	Drug Target	Phase 3: June 2008	2WGH	31.2%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP02383 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0489c	56707631	trxB	thioredoxin reductase [Francisella tular...	316	Drug Target	Phase 3: June 2008	1CL0	66.8%	Francisella tularensis	Energy metabolism	Electron transport

IDP02352 (show subtarget assignments)	1	cloned	No	FTT1334c	56708390		hypothetical protein FTT1334c [Francisel...	169	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP02351 (show subtarget assignments)	1	cloned	No	FTT1112c	56708190	rpoH	RNA polymerase factor sigma-32 [Francise...	292	Drug Target	Phase 3: June 2008	1IW7	25%	Francisella tularensis	Cellular processesTranscription	Adaptations to atypical conditionsTranscription factors

IDP02345 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1220	56708282		5-formyltetrahydroformate cycloligase fa...	182	Drug Target	Phase 3: June 2008	2JCB	28.6%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02334 (show subtarget assignments)	1	soluble	No	FTT0391c	56707540	cspC	cold shock protein [Francisella tularens...	67	Drug Target	Phase 3: June 2008	3I2Z	61.8%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP02326 (show subtarget assignments)	1	purified	No	FTT0976	56708068	trxA2	thioredoxin [Francisella tularensis subs...	108	Drug Target	Phase 3: June 2008	1SYR	41.7%	Francisella tularensis	Energy metabolism	Electron transport

IDP02323 (show subtarget assignments)	1	soluble	No	FTT0560c	56707690	serC	phosphoserine aminotransferase [Francise...	350	Drug Target	Phase 3: June 2008	3QBO	41.1%	Francisella tularensis	Amino acid biosynthesisCentral intermediary metabolism	Aspartate familyOther

IDP02317 (show subtarget assignments)	1	cloned	No	FTT0256c	56707412		lipopolysaccharide protein [Francisella ...	322	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02311 (show subtarget assignments)	1	in_pdb 3MJD	Yes	FTT0437c	56707581	pyrE	orotate phosphoribosyltransferase [Franc...	208	Drug Target	Phase 3: June 2008	3MJD	100%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02308 (show subtarget assignments)	1	expressed	No	FTT1400c	56708448		hypothetical protein FTT1400c [Francisel...	128	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP02302 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0203c	56707367	purH	bifunctional phosphoribosylaminoimidazol...	515	Drug Target	Phase 3: June 2008	3ZZM	47.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02301 (show subtarget assignments)	1	cloned	No	FTT1249	56708311		cell entry (mce) related family protein ...	241	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02299 (show subtarget assignments)	1	cloned	No	FTT0034	56707214	nuoD	NADH dehydrogenase subunit D [Francisell...	417	Drug Target	Phase 3: June 2008	2FUG	42.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP02295 (show subtarget assignments)	1	cloned	No	FTT1212c	56708274	gloA	lactoylglutathione lyase [Francisella tu...	127	Drug Target	Phase 3: June 2008	1F9Z	56.7%	Francisella tularensis	Energy metabolism	Other

IDP02294 (show subtarget assignments)	1	cloned	No	FTT0483c	56707625		hypothetical protein FTT0483c [Francisel...	295	Drug Target	Phase 3: June 2008	2YKR	39.7%	Francisella tularensis	Unknown function	General

IDP02288 (show subtarget assignments)	1	cloned	No	FTT0932	56708030		ROK family protein [Francisella tularens...	283	Drug Target	Phase 3: June 2008	2YHY	29.2%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02287 (show subtarget assignments)	1	purified	No	FTT1161	56708232	adk	adenylate kinase [Francisella tularensis...	218	Drug Target	Phase 3: June 2008	1AKE	56.4%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP02285 (show subtarget assignments)	1	soluble	No	FTT0132	56707303	glpA	anaerobic glycerol-3-phosphate dehydroge...	510	Drug Target	Phase 3: June 2008	3DA1	33.1%	Francisella tularensis	Energy metabolism	Other

IDP02282 (show subtarget assignments)	1	cloned	No	FTT0491c	56707633	gph	phosphoglycolate phosphatase [Francisell...	224	Drug Target	Phase 3: June 2008	2HSZ	32.6%	Francisella tularensis	Energy metabolism	Sugars

IDP02279 (show subtarget assignments)	1	crystallized	No	FTT1164c	56708234	era	GTP-binding protein Era [Francisella tul...	297	Drug Target	Phase 3: June 2008	1EGA	48.5%	Francisella tularensis	Cellular processesRegulatory functions	Cell divisionRNA interactions

IDP90001 (show subtarget assignments)	8	cloned	No	FTT0094c	56603762	qseC	sensor histidine kinase	475	Drug Target (Community Request)	Community Requests	3A0R	15.8%	Francisella tularensis

IDP04570 (show subtarget assignments)	1	soluble	No	FTT0153	56707323	rplS	50S ribosomal protein L19 [Francisella t...	115	drug target; conserved gene;	Phase 4: April 2009	1VS6	58.3%	Francisella tularensis	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP04629 (show subtarget assignments)	1	soluble	No	CBU_0151	29653509	queF	7-cyano-7-deazaguanine reductase [Coxiel...	278	drug target; conserved gene;	Phase 4: April 2009	3BP1	51.4%	Coxiella burnetii	Hypothetical proteins	Conserved

IDP04044 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1530	56708564	fadB/acbP	fusion product of 3-hydroxacyl-CoA dehyd...	898	drug target; conserved gene;	Phase 4: April 2009	3K6J	11.7%	Francisella tularensis	Fatty acid and phospholipid metabolism	Degradation

IDP04655 (show subtarget assignments)	1	soluble	No	FTT1531	56708565	fadA	acetyl-CoA acetyltransferase [Francisell...	395	drug target; conserved gene;	Phase 4: April 2009	1ULQ	45.7%	Francisella tularensis	Fatty acid and phospholipid metabolism	Other

IDP04114 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1611	115347358		conserved hypothetical protein [Yersinia...	117	drug target; conserved gene;	Phase 4: April 2009	3N1S	84.6%	Yersinia pestis	Unknown function	General

IDP04636 (show subtarget assignments)	1	soluble	No	FTT0238	56707395	aroE1	shikimate 5-dehydrogenase [Francisella t...	257	drug target; conserved gene;	Phase 4: April 2009	3O8Q	36.8%	Francisella tularensis

IDP04650 (show subtarget assignments)	1	expressed	No	FTT1302	56708360		hypothetical protein FTT_1302 [Francisel...	276	drug target; conserved gene;	Phase 4: April 2009	3GBP	88.3%	Francisella tularensis

IDP04651 (show subtarget assignments)	1	cloned	No	FTT1417	56708464		carbon-nitrogen hydrolase [Francisella t...	261	drug target; conserved gene;	Phase 4: April 2009	2E11	34.3%	Francisella tularensis

IDP04648 (show subtarget assignments)	1	selected	No	FTT1245	56708307	rluD	ribosomal large subunit pseudouridine sy...	332	drug target; conserved gene;	Phase 4: April 2009	1V9F	43.1%	Francisella tularensis	Protein synthesis	tRNA and rRNA base modification

IDP04086 (show subtarget assignments)	1	expressed	No	VC2256	15642254		undecaprenyl diphosphate synthase [Vibri...	256	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1JP3	54.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04491 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3765	218930769	pepQ	proline dipeptidase [Yersinia pestis CO9...	443	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RVA	54.8%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04152 (show subtarget assignments)	1	cloned	No	YPO3919	218930919		HlyD family secretion protein [Yersinia ...	442	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04168 (show subtarget assignments)	1	purified	No	VC2142	15642141		flagellin [Vibrio cholerae O1 biovar elt...	376	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3K8V	37.5%	Vibrio cholerae	Cellular processes	Chemotaxis and motility

IDP04364 (show subtarget assignments)	1	crystallized	No	VC0767	15640786		inositol-5-monophosphate dehydrogenase [...	489	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3TSB	56.6%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04377 (show subtarget assignments)	1	soluble	No	CPF_2652	110798678		putative maltose/maltodextrin ABC transp...	408	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1URG	38.7%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04410 (show subtarget assignments)	1	cloned	No	VC1047	9655512		fatty oxidation complex, alpha subunit [...	724	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1WDK	36.4%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Degradation

IDP04009 (show subtarget assignments)	1	cloned	No	VC2277	15642275		xanthine-guanine phosphoribosyltransfera...	154	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A95	68.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP04234 (show subtarget assignments)	1	cloned	No	CPF_0807	110799166		iron compound ABC transporter, iron comp...	314	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HXP	29.3%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04242 (show subtarget assignments)	1	cloned	No	CPF_1113	110798641		sugar ABC transporter, sugar-binding pro...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3QUF	22.9%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04513 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_2363	110799064		putative thiamin biosynthesis lipoprotei...	343	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1VRM	29.2%	Clostridium perfringens	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP04169 (show subtarget assignments)	1	in_crystallization_trials	No	VC2180	15642179	hemA	glutamyl-tRNA reductase [Vibrio cholerae...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GPJ	35.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04718 (show subtarget assignments)	1	cloned	No	YPO0838	218928014		putative acetylglucosamine-6-phosphate d...	388	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2VHL	36.1%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP04378 (show subtarget assignments)	1	cloned	No	CPF_2335	110799804		extracellular solute-binding protein [Cl...	482	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04155 (show subtarget assignments)	1	cloned	No	VC0547	9654975		aspartokinase, alpha and beta subunits [...	395	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3L76	39.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP04196 (show subtarget assignments)	1	cloned	No	CPF_2502	110800817		putative lipoprotein [Clostridium perfri...	507	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04408 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_1426	110798602		iron(III) ABC transporter, iron(III)-bin...	332	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3GFV	24.1%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04198 (show subtarget assignments)	1	soluble	No	CPF_2555	110799167		oligopeptide/dipeptide ABC transporter, ...	580	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XOC	29.8%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP04062 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0637	9658051		oxygen-insensitive NAD(P)H nitroreductas...	217	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HZN	59.4%	Vibrio cholerae	Central intermediary metabolism	Other

IDP04059 (show subtarget assignments)	1	expressed	No	VC1973	9656513		naphthoate synthase [Vibrio cholerae O1 ...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3H02	80.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04007 (show subtarget assignments)	1	expressed	No	VC1319	15641331		sensor histidine kinase [Vibrio cholerae...	440	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Vibrio cholerae	Regulatory functions	Other

IDP04329 (show subtarget assignments)	1	expressed	No	CPF_1466	110801108		putative lipoprotein [Clostridium perfri...	483	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04640 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0559c	56707689	cmk	cytidylate kinase [Francisella tularensi...	221	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CKE	47.1%	Francisella tularensis

IDP04153 (show subtarget assignments)	1	cloned	No	YPO3975	218930970	opdA	oligopeptidase A [Yersinia pestis CO92]	680	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1S4B	30.7%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04015 (show subtarget assignments)	1	purified	No	VC0395	15640422		UTP--glucose-1-phosphate uridylyltransfe...	291	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3JUJ	58.1%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides

IDP04085 (show subtarget assignments)	1	expressed	No	VC0525	15640547		2-amino-4-hydroxy-6-hydroxymethyldihydro...	195	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2BMB	30.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04170 (show subtarget assignments)	1	cloned	No	VC2183	15642182		ribose-phosphate pyrophosphokinase [Vibr...	314	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3DAH	63.7%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04482 (show subtarget assignments)	1	in_pdb 3P2A	Yes	YPO3270	218930295	trxC	thioredoxin 2 [Yersinia pestis CO92]	145	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3P2A	100%	Yersinia pestis	Energy metabolism	Electron transport

IDP04158 (show subtarget assignments)	1	expressed	No	VC1088	15641101		sensor histidine kinase [Vibrio cholerae...	534	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3D36	13.5%	Vibrio cholerae	Regulatory functions	Other

IDP04641 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0693c	56707813	mutM	formamidopyrimidine-DNA glycosylase [Fra...	274	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1K82	43.1%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP04406 (show subtarget assignments)	1	in_crystallization_trials	No	VC1053	15641066		adenine phosphoribosyltransferase [Vibri...	181	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2DY0	73.5%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP04004 (show subtarget assignments)	1	cloned	No	CPF_1305	110799423	mtnN	5'-methylthioadenosine/S-adenosylhomocys...	266	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3EEI	34.6%	Clostridium perfringens	Central intermediary metabolism	Other

IDP04566 (show subtarget assignments)	1	expressed	No	CPF_1876	110800623		putative lipoprotein [Clostridium perfri...	221	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04134 (show subtarget assignments)	1	expressed	No	FTT0666c	56707787		methylpurine-DNA glycosylase family prot...	193	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BNK	39.7%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP04167 (show subtarget assignments)	1	cloned	No	VC1977	9656518		aspartate aminotransferase, putative [Vi...	404	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XI9	40.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP04341 (show subtarget assignments)	1	expressed	No	CBU_0634	215919011		putative aerobic respiration control sen...	630	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	14.8%	Coxiella burnetii	Regulatory functions	Protein interactions

IDP04173 (show subtarget assignments)	1	expressed	No	VC2490	15642486		2-isopropylmalate synthase [Vibrio chole...	516	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RMJ	39%	Vibrio cholerae	Amino acid biosynthesis	Pyruvate family

IDP04091 (show subtarget assignments)	1	cloned	No	CPF_1278	110799680		putative lipoprotein [Clostridium perfri...	155	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04321 (show subtarget assignments)	1	cloned	No	VC0756	15640775	ndk	nucleoside diphosphate kinase [Vibrio ch...	142	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2HUR	64.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP04649 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1283	56708343	trmE	tRNA modification GTPase TrmE [Francisel...	450	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XZP	36.1%	Francisella tularensis	Protein synthesis	tRNA and rRNA base modification

IDP04565 (show subtarget assignments)	1	cloned	No	CPF_1805	110798813		putative lipoprotein [Clostridium perfri...	281	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04567 (show subtarget assignments)	1	cloned	No	CPF_2099	110800052		putative lipoprotein [Clostridium perfri...	343	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04632 (show subtarget assignments)	1	cloned	No	CBU_2005	29655288	rstB	signal transduction histidine kinase-lik...	425	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.2%	Coxiella burnetii	Regulatory functions	Protein interactions

IDP04639 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0556c	56707686	oxyR	oxidative stress transcriptional regulat...	289	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2H98	26.2%	Francisella tularensis	Regulatory functions	DNA interactions

IDP04045 (show subtarget assignments)	1	soluble	No	FTT1747	56708745		outer membrane protein [Francisella tula...	191	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Francisella tularensis

IDP04048 (show subtarget assignments)	1	in_crystallization_trials	No	VC1112	15641125		biotin synthase [Vibrio cholerae O1 biov...	350	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1R30	69.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04642 (show subtarget assignments)	1	expressed	No	FTT0716	56707835	upp	uracil phosphoribosyltransferase [Franci...	214	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2EHJ	69.2%	Francisella tularensis

IDP04188 (show subtarget assignments)	1	expressed	No	VCA0939	15601692		sensory box/GGDEF family protein [Vibrio...	321	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3BRE	20.6%	Vibrio cholerae	Regulatory functions	Other

IDP04563 (show subtarget assignments)	1	soluble	No	CPF_1296	110798598		iron chelate ABC transporter solute-bind...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2CHU	27.9%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04161 (show subtarget assignments)	1	cloned	No	VC1172	9655648		anthranilate phosphoribosyltransferase [...	353	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KGZ	59.5%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP04043 (show subtarget assignments)	1	soluble	No	VCA0565	15601324		sensor histidine kinase [Vibrio cholerae...	499	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BXD	6%	Vibrio cholerae	Regulatory functions	Other

IDP04165 (show subtarget assignments)	1	expressed	No	VC1521	15641529		sensor histidine kinase [Vibrio cholerae...	677	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	11.7%	Vibrio cholerae	Regulatory functions	Other

IDP04049 (show subtarget assignments)	1	soluble	No	VC1132	15641145	hisG	ATP phosphoribosyltransferase [Vibrio ch...	304	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1H3D	65.8%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP04295 (show subtarget assignments)	1	cloned	No	FTT0031	56707211	nuoA	NADH dehydrogenase I, A subunit [Francis...	132	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RKO	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP04548 (show subtarget assignments)	1	cloned	No	CPF_2413	110801184		ABC transporter, substrate-binding prote...	298	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2O1E	36.4%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP02526
(show subtarget assignments)

1

cloned

No

FTT1600c

56708620

fumA

fumerate hydratase [Francisella tularens...

504

Drug Target

Phase 3: June 2008

2ISB

13.7%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02520
(show subtarget assignments)

1

soluble

No

FTT0833

56707942

ispH

IspH protein [Francisella tularensis sub...

318

Drug Target

Phase 3: June 2008

3F7T

51.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02485
(show subtarget assignments)

1

cloned

No

FTT1539c

56708571

hypothetical protein FTT1539c [Francisel...

476

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP02457
(show subtarget assignments)

1

expressed

No

FTT1248

56708310

ABC transporter, ATP-binding protein [Fr...

253

Drug Target

Phase 3: June 2008

1B0U

31.1%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02450
(show subtarget assignments)

1

expressed

No

FTT1475

56708515

galT

galactose-1-phosphate uridylyltransferas...

341

Drug Target

Phase 3: June 2008

1HXQ

51.6%

Francisella tularensis

Energy metabolism

Sugars

IDP02448
(show subtarget assignments)

1

in_pdb
3KD3

No

FTT0568

56707697

hypothetical protein FTT0568 [Francisell...

216

Drug Target

Phase 3: June 2008

3KD3

100%

Francisella tularensis

Amino acid biosynthesis

Serine family

IDP02441
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1478c

56708518

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

250

Drug Target

Phase 3: June 2008

3TQD

51.2%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02437
(show subtarget assignments)

1

expressed

No

FTT1226c

56708288

iscS

cysteine desulfarase [Francisella tulare...

391

Drug Target

Phase 3: June 2008

1P3W

41.9%

Francisella tularensis

Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers

Pyruvate familyOther

IDP02434
(show subtarget assignments)

1

soluble

No

FTT1241

56708303

glyA

serine hydroxymethyltransferase [Francis...

417

Drug Target

Phase 3: June 2008

3GBX

67.1%

Francisella tularensis

Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin

Serine familyFolic acid,Purine ribonucleotide biosynthesis

IDP02430
(show subtarget assignments)

1

expressed

No

FTT1151c

56708222

hypothetical protein FTT1151c [Francisel...

95

Drug Target

Phase 3: June 2008

2JR5

25.3%

Francisella tularensis

Unknown function

General

IDP02423
(show subtarget assignments)

1

cloned

No

FTT1138

56708213

hemH

ferrochelatase [Francisella tularensis s...

333

Drug Target

Phase 3: June 2008

1HRK

27.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02405
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1803c

56708789

trpR

trp operon repressor [Francisella tulare...

95

Drug Target

Phase 3: June 2008

1CO0

30.5%

Francisella tularensis

Amino acid biosynthesisRegulatory functions

Aromatic amino acid familyDNA interactions

IDP02402
(show subtarget assignments)

1

purified

No

FTT1778c

56708771

hypothetical protein FTT1778c [Francisel...

130

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP02397
(show subtarget assignments)

1

purified

No

FTT1326

56708383

udp

uridine phosphorylase [Francisella tular...

267

Drug Target

Phase 3: June 2008

3O6V

43.1%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02391
(show subtarget assignments)

1

cloned

No

FTT0534c

56707667

nrdA

ribonucleotide-diphosphate reductase sub...

590

Drug Target

Phase 3: June 2008

2WGH

31.2%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP02383
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0489c

56707631

trxB

thioredoxin reductase [Francisella tular...

316

Drug Target

Phase 3: June 2008

1CL0

66.8%

Francisella tularensis

Energy metabolism

Electron transport

IDP02352
(show subtarget assignments)

1

cloned

No

FTT1334c

56708390

hypothetical protein FTT1334c [Francisel...

169

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02351
(show subtarget assignments)

1

cloned

No

FTT1112c

56708190

rpoH

RNA polymerase factor sigma-32 [Francise...

292

Drug Target

Phase 3: June 2008

1IW7

25%

Francisella tularensis

Cellular processesTranscription

Adaptations to atypical conditionsTranscription factors

IDP02345
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1220

56708282

5-formyltetrahydroformate cycloligase fa...

182

Drug Target

Phase 3: June 2008

2JCB

28.6%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02334
(show subtarget assignments)

1

soluble

No

FTT0391c

56707540

cspC

cold shock protein [Francisella tularens...

67

Drug Target

Phase 3: June 2008

3I2Z

61.8%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP02326
(show subtarget assignments)

1

purified

No

FTT0976

56708068

trxA2

thioredoxin [Francisella tularensis subs...

108

Drug Target

Phase 3: June 2008

1SYR

41.7%

Francisella tularensis

Energy metabolism

Electron transport

IDP02323
(show subtarget assignments)

1

soluble

No

FTT0560c

56707690

serC

phosphoserine aminotransferase [Francise...

350

Drug Target

Phase 3: June 2008

3QBO

41.1%

Francisella tularensis

Amino acid biosynthesisCentral intermediary metabolism

Aspartate familyOther

IDP02317
(show subtarget assignments)

1

cloned

No

FTT0256c

56707412

lipopolysaccharide protein [Francisella ...

322

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02311
(show subtarget assignments)

1

in_pdb
3MJD

Yes

FTT0437c

56707581

pyrE

orotate phosphoribosyltransferase [Franc...

208

Drug Target

Phase 3: June 2008

3MJD

100%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02308
(show subtarget assignments)

1

expressed

No

FTT1400c

56708448

hypothetical protein FTT1400c [Francisel...

128

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02302
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0203c

56707367

purH

bifunctional phosphoribosylaminoimidazol...

515

Drug Target

Phase 3: June 2008

3ZZM

47.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02301
(show subtarget assignments)

1

cloned

No

FTT1249

56708311

cell entry (mce) related family protein ...

241

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02299
(show subtarget assignments)

1

cloned

No

FTT0034

56707214

nuoD

NADH dehydrogenase subunit D [Francisell...

417

Drug Target

Phase 3: June 2008

2FUG

42.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP02295
(show subtarget assignments)

1

cloned

No

FTT1212c

56708274

gloA

lactoylglutathione lyase [Francisella tu...

127

Drug Target

Phase 3: June 2008

1F9Z

56.7%

Francisella tularensis

Energy metabolism

Other

IDP02294
(show subtarget assignments)

1

cloned

No

FTT0483c

56707625

hypothetical protein FTT0483c [Francisel...

295

Drug Target

Phase 3: June 2008

2YKR

39.7%

Francisella tularensis

Unknown function

General

IDP02288
(show subtarget assignments)

1

cloned

No

FTT0932

56708030

ROK family protein [Francisella tularens...

283

Drug Target

Phase 3: June 2008

2YHY

29.2%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02287
(show subtarget assignments)

1

purified

No

FTT1161

56708232

adk

adenylate kinase [Francisella tularensis...

218

Drug Target

Phase 3: June 2008

1AKE

56.4%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP02285
(show subtarget assignments)

1

soluble

No

FTT0132

56707303

glpA

anaerobic glycerol-3-phosphate dehydroge...

510

Drug Target

Phase 3: June 2008

3DA1

33.1%

Francisella tularensis

Energy metabolism

Other

IDP02282
(show subtarget assignments)

1

cloned

No

FTT0491c

56707633

gph

phosphoglycolate phosphatase [Francisell...

224

Drug Target

Phase 3: June 2008

2HSZ

32.6%

Francisella tularensis

Energy metabolism

Sugars

IDP02279
(show subtarget assignments)

1

crystallized

No

FTT1164c

56708234

era

GTP-binding protein Era [Francisella tul...

297

Drug Target

Phase 3: June 2008

1EGA

48.5%

Francisella tularensis

Cellular processesRegulatory functions

Cell divisionRNA interactions

IDP90001
(show subtarget assignments)

8

cloned

No

FTT0094c

56603762

qseC

sensor histidine kinase

475

Drug Target (Community Request)

Community Requests

3A0R

15.8%

Francisella tularensis

IDP04570
(show subtarget assignments)

1

soluble

No

FTT0153

56707323

rplS

50S ribosomal protein L19 [Francisella t...

115

drug target; conserved gene;

Phase 4: April 2009

1VS6

58.3%

Francisella tularensis

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP04629
(show subtarget assignments)

1

soluble

No

CBU_0151

29653509

queF

7-cyano-7-deazaguanine reductase [Coxiel...

278

drug target; conserved gene;

Phase 4: April 2009

3BP1

51.4%

Coxiella burnetii

Hypothetical proteins

Conserved

IDP04044
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1530

56708564

fadB/acbP

fusion product of 3-hydroxacyl-CoA dehyd...

898

drug target; conserved gene;

Phase 4: April 2009

3K6J

11.7%

Francisella tularensis

Fatty acid and phospholipid metabolism

Degradation

IDP04655
(show subtarget assignments)

1

soluble

No

FTT1531

56708565

fadA

acetyl-CoA acetyltransferase [Francisell...

395

drug target; conserved gene;

Phase 4: April 2009

1ULQ

45.7%

Francisella tularensis

Fatty acid and phospholipid metabolism

Other

IDP04114
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1611

115347358

conserved hypothetical protein [Yersinia...

117

drug target; conserved gene;

Phase 4: April 2009

3N1S

84.6%

Yersinia pestis

Unknown function

General

IDP04636
(show subtarget assignments)

1

soluble

No

FTT0238

56707395

aroE1

shikimate 5-dehydrogenase [Francisella t...

257

drug target; conserved gene;

Phase 4: April 2009

3O8Q

36.8%

Francisella tularensis

IDP04650
(show subtarget assignments)

1

expressed

No

FTT1302

56708360

hypothetical protein FTT_1302 [Francisel...

276

drug target; conserved gene;

Phase 4: April 2009

3GBP

88.3%

Francisella tularensis

IDP04651
(show subtarget assignments)

1

cloned

No

FTT1417

56708464

carbon-nitrogen hydrolase [Francisella t...

261

drug target; conserved gene;

Phase 4: April 2009

2E11

34.3%

Francisella tularensis

IDP04648
(show subtarget assignments)

1

selected

No

FTT1245

56708307

rluD

ribosomal large subunit pseudouridine sy...

332

drug target; conserved gene;

Phase 4: April 2009

1V9F

43.1%

Francisella tularensis

Protein synthesis

tRNA and rRNA base modification

IDP04086
(show subtarget assignments)

1

expressed

No

VC2256

15642254

undecaprenyl diphosphate synthase [Vibri...

256

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1JP3

54.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04491
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3765

218930769

pepQ

proline dipeptidase [Yersinia pestis CO9...

443

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RVA

54.8%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04152
(show subtarget assignments)

1

cloned

No

YPO3919

218930919

HlyD family secretion protein [Yersinia ...

442

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04168
(show subtarget assignments)

1

purified

No

VC2142

15642141

flagellin [Vibrio cholerae O1 biovar elt...

376

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3K8V

37.5%

Vibrio cholerae

Cellular processes

Chemotaxis and motility

IDP04364
(show subtarget assignments)

1

crystallized

No

VC0767

15640786

inositol-5-monophosphate dehydrogenase [...

489

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3TSB

56.6%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04377
(show subtarget assignments)

1

soluble

No

CPF_2652

110798678

putative maltose/maltodextrin ABC transp...

408

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1URG

38.7%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04410
(show subtarget assignments)

1

cloned

No

VC1047

9655512

fatty oxidation complex, alpha subunit [...

724

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1WDK

36.4%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Degradation

IDP04009
(show subtarget assignments)

1

cloned

No

VC2277

15642275

xanthine-guanine phosphoribosyltransfera...

154

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A95

68.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP04234
(show subtarget assignments)

1

cloned

No

CPF_0807

110799166

iron compound ABC transporter, iron comp...

314

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HXP

29.3%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04242
(show subtarget assignments)

1

cloned

No

CPF_1113

110798641

sugar ABC transporter, sugar-binding pro...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3QUF

22.9%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04513
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_2363

110799064

putative thiamin biosynthesis lipoprotei...

343

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1VRM

29.2%

Clostridium perfringens

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP04169
(show subtarget assignments)

1

in_crystallization_trials

No

VC2180

15642179

hemA

glutamyl-tRNA reductase [Vibrio cholerae...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GPJ

35.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04718
(show subtarget assignments)

1

cloned

No

YPO0838

218928014

putative acetylglucosamine-6-phosphate d...

388

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2VHL

36.1%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP04378
(show subtarget assignments)

1

cloned

No

CPF_2335

110799804

extracellular solute-binding protein [Cl...

482

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04155
(show subtarget assignments)

1

cloned

No

VC0547

9654975

aspartokinase, alpha and beta subunits [...

395

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3L76

39.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP04196
(show subtarget assignments)

1

cloned

No

CPF_2502

110800817

putative lipoprotein [Clostridium perfri...

507

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04408
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_1426

110798602

iron(III) ABC transporter, iron(III)-bin...

332

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3GFV

24.1%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04198
(show subtarget assignments)

1

soluble

No

CPF_2555

110799167

oligopeptide/dipeptide ABC transporter, ...

580

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XOC

29.8%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP04062
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0637

9658051

oxygen-insensitive NAD(P)H nitroreductas...

217

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HZN

59.4%

Vibrio cholerae

Central intermediary metabolism

Other

IDP04059
(show subtarget assignments)

1

expressed

No

VC1973

9656513

naphthoate synthase [Vibrio cholerae O1 ...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3H02

80.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04007
(show subtarget assignments)

1

expressed

No

VC1319

15641331

sensor histidine kinase [Vibrio cholerae...

440

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Vibrio cholerae

Regulatory functions

Other

IDP04329
(show subtarget assignments)

1

expressed

No

CPF_1466

110801108

putative lipoprotein [Clostridium perfri...

483

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04640
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0559c

56707689

cmk

cytidylate kinase [Francisella tularensi...

221

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CKE

47.1%

Francisella tularensis

IDP04153
(show subtarget assignments)

1

cloned

No

YPO3975

218930970

opdA

oligopeptidase A [Yersinia pestis CO92]

680

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1S4B

30.7%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04015
(show subtarget assignments)

1

purified

No

VC0395

15640422

UTP--glucose-1-phosphate uridylyltransfe...

291

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3JUJ

58.1%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

IDP04085
(show subtarget assignments)

1

expressed

No

VC0525

15640547

2-amino-4-hydroxy-6-hydroxymethyldihydro...

195

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2BMB

30.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04170
(show subtarget assignments)

1

cloned

No

VC2183

15642182

ribose-phosphate pyrophosphokinase [Vibr...

314

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3DAH

63.7%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04482
(show subtarget assignments)

1

in_pdb
3P2A

Yes

YPO3270

218930295

trxC

thioredoxin 2 [Yersinia pestis CO92]

145

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3P2A

100%

Yersinia pestis

Energy metabolism

Electron transport

IDP04158
(show subtarget assignments)

1

expressed

No

VC1088

15641101

sensor histidine kinase [Vibrio cholerae...

534

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3D36

13.5%

Vibrio cholerae

Regulatory functions

Other

IDP04641
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0693c

56707813

mutM

formamidopyrimidine-DNA glycosylase [Fra...

274

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1K82

43.1%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP04406
(show subtarget assignments)

1

in_crystallization_trials

No

VC1053

15641066

adenine phosphoribosyltransferase [Vibri...

181

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2DY0

73.5%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP04004
(show subtarget assignments)

1

cloned

No

CPF_1305

110799423

mtnN

5'-methylthioadenosine/S-adenosylhomocys...

266

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3EEI

34.6%

Clostridium perfringens

Central intermediary metabolism

Other

IDP04566
(show subtarget assignments)

1

expressed

No

CPF_1876

110800623

putative lipoprotein [Clostridium perfri...

221

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04134
(show subtarget assignments)

1

expressed

No

FTT0666c

56707787

methylpurine-DNA glycosylase family prot...

193

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BNK

39.7%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP04167
(show subtarget assignments)

1

cloned

No

VC1977

9656518

aspartate aminotransferase, putative [Vi...

404

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XI9

40.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP04341
(show subtarget assignments)

1

expressed

No

CBU_0634

215919011

putative aerobic respiration control sen...

630

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

14.8%

Coxiella burnetii

Regulatory functions

Protein interactions

IDP04173
(show subtarget assignments)

1

expressed

No

VC2490

15642486

2-isopropylmalate synthase [Vibrio chole...

516

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RMJ

39%

Vibrio cholerae

Amino acid biosynthesis

Pyruvate family

IDP04091
(show subtarget assignments)

1

cloned

No

CPF_1278

110799680

putative lipoprotein [Clostridium perfri...

155

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04321
(show subtarget assignments)

1

cloned

No

VC0756

15640775

ndk

nucleoside diphosphate kinase [Vibrio ch...

142

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2HUR

64.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP04649
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1283

56708343

trmE

tRNA modification GTPase TrmE [Francisel...

450

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XZP

36.1%

Francisella tularensis

Protein synthesis

tRNA and rRNA base modification

IDP04565
(show subtarget assignments)

1

cloned

No

CPF_1805

110798813

putative lipoprotein [Clostridium perfri...

281

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04567
(show subtarget assignments)

1

cloned

No

CPF_2099

110800052

putative lipoprotein [Clostridium perfri...

343

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04632
(show subtarget assignments)

1

cloned

No

CBU_2005

29655288

rstB

signal transduction histidine kinase-lik...

425

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.2%

Coxiella burnetii

Regulatory functions

Protein interactions

IDP04639
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0556c

56707686

oxyR

oxidative stress transcriptional regulat...

289

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2H98

26.2%

Francisella tularensis

Regulatory functions

DNA interactions

IDP04045
(show subtarget assignments)

1

soluble

No

FTT1747

56708745

outer membrane protein [Francisella tula...

191

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Francisella tularensis

IDP04048
(show subtarget assignments)

1

in_crystallization_trials

No

VC1112

15641125

biotin synthase [Vibrio cholerae O1 biov...

350

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1R30

69.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04642
(show subtarget assignments)

1

expressed

No

FTT0716

56707835

upp

uracil phosphoribosyltransferase [Franci...

214

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2EHJ

69.2%

Francisella tularensis

IDP04188
(show subtarget assignments)

1

expressed

No

VCA0939

15601692

sensory box/GGDEF family protein [Vibrio...

321

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3BRE

20.6%

Vibrio cholerae

Regulatory functions

Other

IDP04563
(show subtarget assignments)

1

soluble

No

CPF_1296

110798598

iron chelate ABC transporter solute-bind...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2CHU

27.9%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04161
(show subtarget assignments)

1

cloned

No

VC1172

9655648

anthranilate phosphoribosyltransferase [...

353

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KGZ

59.5%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP04043
(show subtarget assignments)

1

soluble

No

VCA0565

15601324

sensor histidine kinase [Vibrio cholerae...

499

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BXD

6%

Vibrio cholerae

Regulatory functions

Other

IDP04165
(show subtarget assignments)

1

expressed

No

VC1521

15641529

sensor histidine kinase [Vibrio cholerae...

677

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

11.7%

Vibrio cholerae

Regulatory functions

Other

IDP04049
(show subtarget assignments)

1

soluble

No

VC1132

15641145

hisG

ATP phosphoribosyltransferase [Vibrio ch...

304

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1H3D

65.8%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP04295
(show subtarget assignments)

1

cloned

No

FTT0031

56707211

nuoA

NADH dehydrogenase I, A subunit [Francis...

132

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RKO

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP04548
(show subtarget assignments)

1

cloned

No

CPF_2413

110801184

ABC transporter, substrate-binding prote...

298

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2O1E

36.4%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

Targets