Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02485 (show subtarget assignments)	1	cloned	No	FTT1539c	56708571		hypothetical protein FTT1539c [Francisel...	476	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP02498 (show subtarget assignments)	1	cloned	No	FTT1556c	56708584	lepB	signal peptidase I [Francisella tularens...	287	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1B12	33.4%	Francisella tularensis	Protein fate	Protein and peptide secretion and trafficking

IDP02492 (show subtarget assignments)	1	crystallized	No	FTT1559c	56708586	proC	pyrroline-5-carboxylate reductase [Franc...	274	Conserved; Drug target functions	Phase 3: June 2008	3TRI	37.6%	Francisella tularensis	Amino acid biosynthesis	Glutamate family

IDP02624 (show subtarget assignments)	1	soluble	No	FTT1562	56708589	ispA	geranyltranstransferase [Francisella tul...	293	Conserved; Drug target functions	Phase 3: June 2008	2FOR	40.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01633 (show subtarget assignments)	1	soluble	No	FTT1569c	56708595	lpxA	UDP-N-acetylglucosamine acyltransferase ...	259	Conserved; Drug target functions	Phase 3: June 2008	1LXA	43.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01632 (show subtarget assignments)	1	cloned	No	FTT1571c	56708597	lpxD	UDP-3-O-[3-hydroxymyristoyl] glucosamine...	337	Drug Target	Phase 3: June 2008	3EH0	45.1%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02240 (show subtarget assignments)	1	cloned	No	FTT1572c	56708598	ompH	outer membrane protein OmpH [Francisella...	167	Drug Target	Phase 3: June 2008	1SG2	23.4%	Francisella tularensis	Cell envelopeMobile and extrachromosomal element functions	OtherProphage functions

IDP02504 (show subtarget assignments)	1	purified	No	FTT1578c	56708604	ung	uracil-DNA glycosylase [Francisella tula...	220	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1EUG	58.6%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP02526 (show subtarget assignments)	1	cloned	No	FTT1600c	56708620	fumA	fumerate hydratase [Francisella tularens...	504	Drug Target	Phase 3: June 2008	2ISB	13.7%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02672 (show subtarget assignments)	1	cloned	No	FTT1602	56708622		hypothetical protein FTT1602 [Francisell...	114	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelopeUnknown function	OtherGeneral

IDP01607 (show subtarget assignments)	1	cloned	No	FTT1608	56708628		ABC transporter, ATP-binding protein [Fr...	267	Conserved; Drug target functions	Phase 3: June 2008	3DHW	30%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02678 (show subtarget assignments)	1	cloned	No	FTT1653	56708665		hypothetical protein FTT1653 [Francisell...	135	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP02512 (show subtarget assignments)	1	soluble	No	FTT1663	56708674	carA	carbamoyl phosphate synthase small subun...	388	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1BXR	48.5%	Francisella tularensis	N/A	N/A

IDP01692 (show subtarget assignments)	1	cloned	No	FTT1671	56708681	ribD	riboflavin biosynthesis protein ribD [Fr...	355	Conserved; Drug target functions	Phase 3: June 2008	2B3Z	37.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02186 (show subtarget assignments)	1	soluble	No	FTT1672	56708682	ribB	riboflavin synthase subunit alpha [Franc...	201	Conserved; Drug target functions	Phase 3: June 2008	1KZL	35.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00332 (show subtarget assignments)	1	purified	No	FTT1673	56708683	ribA	riboflavin biosynthesis protein ribA/GTP...	403	Drug Target Function	Phase 2: March 2008	1G57	27%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02530 (show subtarget assignments)	1	soluble	No	FTT1674	56708684	ribH	riboflavin synthase beta subunit (6,7-di...	147	Conserved; Drug target functions	Phase 3: June 2008	1RVV	45.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01652 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1695	56708704	groES	co-chaperonin GroES [Francisella tularen...	95	Conserved; Drug target functions	Phase 3: June 2008	1AON	56.8%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP02516 (show subtarget assignments)	1	purified	No	FTT1696	56708705	groEL	chaperonin GroEL [Francisella tularensis...	544	Conserved; Drug target functions	Phase 3: June 2008	1AON	73.3%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP04656 (show subtarget assignments)	1	cloned	No	FTT1720c	56708726	purL	phosphoribosylformylglycinamidine syntha...	1290	conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04657 (show subtarget assignments)	1	expressed	No	FTT1721c	56708727	purF	amidophosphoribosyltransferase [Francise...	496	conserved gene; putative drug target function;	Phase 4: April 2009	1ECB	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01790 (show subtarget assignments)	1	purified	No	FTT1731c	56708736	obgE	GTPase ObgE [Francisella tularensis subs...	334	Drug Target	Phase 3: June 2008	1UDX	45.5%	Francisella tularensis	Unknown function	General

IDP04658 (show subtarget assignments)	1	purified	No	FTT1736c	56708739	kdpD	two component sensor protein kdpD [Franc...	893	conserved gene;	Phase 4: April 2009	2R8R	11.4%	Francisella tularensis

IDP02538 (show subtarget assignments)	1	soluble	No	FTT1746	56708744		peptidase [Francisella tularensis subsp....	307	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3RST	23.1%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04045 (show subtarget assignments)	1	soluble	No	FTT1747	56708745		outer membrane protein [Francisella tula...	191	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Francisella tularensis

IDP01739 (show subtarget assignments)	1	in_pdb 3KHY	No	FTT1753	56708751	tdcD	propionate kinase [Francisella tularensi...	384	Conserved; Drug target functions	Phase 3: June 2008	3KHY	100%	Francisella tularensis	Energy metabolism	Fermentation

IDP01848 (show subtarget assignments)	1	cloned	No	FTT1754	56708752	pta	phosphate acetyltransferase [Francisella...	698	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1TD9	19.9%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP01625 (show subtarget assignments)	1	expressed	No	FTT1761	56708756		hypothetical protein FTT1761 [Francisell...	239	Drug Target	Phase 3: June 2008			Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP01812 (show subtarget assignments)	1	cloned	No	FTT1764c	56708759		ferredoxin [Francisella tularensis subsp...	107	Conserved; Drug target functions	Phase 3: June 2008	1A6L	64.5%	Francisella tularensis	Energy metabolism	Electron transport

IDP04418 (show subtarget assignments)	1	purified	No	FTT1767c	56708762	purT	phosphoribosylglycinamide formyltransfer...	386	conserved gene; putative drug target function;	Phase 4: April 2009	1EYZ	53.4%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02556 (show subtarget assignments)	1	soluble	No	FTT1769c	56708764	clpB	ClpB protein [Francisella tularensis sub...	859	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1QVR	55.3%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01866 (show subtarget assignments)	1	crystallized	No	FTT1772c	56708766	trpA	tryptophan synthase subunit alpha [Franc...	269	Drug Target	Phase 3: June 2008	3NAV	61%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP02402 (show subtarget assignments)	1	purified	No	FTT1778c	56708771		hypothetical protein FTT1778c [Francisel...	130	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP01667 (show subtarget assignments)	1	expressed	No	FTT1782c	56708774	yjjK	putative ABC transporter ATP-binding pro...	559	Conserved; Drug target functions	Phase 3: June 2008	1YQT	27.3%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP04077 (show subtarget assignments)	1	crystallized	No	FTT1793c	56708781	pepN	aminopeptidase N [Francisella tularensis...	864	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2DQ6	48.9%	Francisella tularensis

IDP01871 (show subtarget assignments)	1	cloned	No	FTT1795c	56708783	trpC	bifunctional indole-3-glycerol phosphate...	453	Conserved; Drug target functions	Phase 3: June 2008	1PII	56.1%	Francisella tularensis	Amino acid biosynthesisFatty acid and phospholipid metabolism	Aromatic amino acid familyHistidine family,Biosynthesis

IDP01878 (show subtarget assignments)	1	cloned	No	FTT1797c	56708785	msrA2	peptide methionine sulfoxide reductase m...	229	Drug Target	Phase 3: June 2008	3PIN	28.4%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP00342 (show subtarget assignments)	1	cloned	No	FTT1802c	56708788	trpE	anthranilate synthase component I	514	Drug Target Function	Phase 2: March 2008	1I1Q	51.1%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP02405 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1803c	56708789	trpR	trp operon repressor [Francisella tulare...	95	Drug Target	Phase 3: June 2008	1CO0	30.5%	Francisella tularensis	Amino acid biosynthesisRegulatory functions	Aromatic amino acid familyDNA interactions

IDP01879 (show subtarget assignments)	1	cloned	No	FTT1804c	56708790	rng	ribonuclease G [Francisella tularensis s...	498	Conserved; Drug target functions	Phase 3: June 2008	2BX2	31.9%	Francisella tularensis	Cellular processesTranscription	Cell divisionRNA processing

IDP91836 (show subtarget assignments)	8	selected	No	GALLO_0038	288904261		Cro/CI family transcriptional regulator ...	299	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus gallolyticus

IDP91836 (show subtarget assignments)	8	selected	No	GALLO_0038	288904261		Cro/CI family transcriptional regulator ...	299	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus gallolyticus

IDP01881 (show subtarget assignments)	1	cloned	No	GBAA0009	47525265	dacA	D-alanyl-D-alanine carboxypeptidase [Bac...	435	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02296 (show subtarget assignments)	1	crystallized	No	GBAA0020	47525275		hypothetical protein GBAA0020 [Bacillus ...	109	Conserved; Involved in sporulation;	Phase 3: June 2008	1YBX	55.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01668 (show subtarget assignments)	1	soluble	No	GBAA0060	47525314		hypothetical protein GBAA0060 [Bacillus ...	160	Essential;	Phase 3: June 2008	2K4K	29.4%	Bacillus anthracis	Unknown function	General

IDP01874 (show subtarget assignments)	1	cloned	No	GBAA0062	47525316		hypothetical protein GBAA0062 [Bacillus ...	476	Conserved;	Phase 3: June 2008	3A2K	46.6%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01892 (show subtarget assignments)	1	in_pdb 3HVU 3KB8 3H83	No	GBAA0063	47525317	hpt-1	hypoxanthine-guanine phosphoribosyltrans...	180	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3H83	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP02213 (show subtarget assignments)	1	expressed	No	GBAA0068	47525322	pabB	para-aminobenzoate synthase component I ...	465	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1QDL	37.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01875 (show subtarget assignments)	1	expressed	No	GBAA0069	47525323	pabA-1	para-aminobenzoate/anthranilate synthase...	195	Conserved; Essential; Drug target functions	Phase 3: June 2008	1QDL	45.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02260 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA0072	47777774	folB	dihydroneopterin aldolase [Bacillus anth...	120	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1DHN	43.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01877 (show subtarget assignments)	1	crystallized	No	GBAA0080	47525336		negative regulator of genetic competence...	811	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PXI	80.1%	Bacillus anthracis	Cellular processes	DNA transformation

IDP02564 (show subtarget assignments)	1	purified	No	GBAA0084	47525340	ispD	2-C-methyl-D-erythritol 4-phosphate cyti...	226	Conserved; Drug target functions	Phase 3: June 2008	1W77	36.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02535 (show subtarget assignments)	1	expressed	No	GBAA0088	47525343	cysE	serine O-acetyltransferase [Bacillus ant...	221	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3GVD	36.2%	Bacillus anthracis	Amino acid biosynthesis	Serine family

IDP01876 (show subtarget assignments)	1	cloned	No	GBAA0095	47525349	secE	preprotein translocase subunit SecE [Bac...	59	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DIN	33.9%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP02148 (show subtarget assignments)	1	cloned	No	GBAA0133	47525389	infA	translation initiation factor IF-1 [Baci...	72	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AH9	72.2%	Bacillus anthracis	Protein synthesis	Translation factors

IDP01670 (show subtarget assignments)	1	cloned	No	GBAA0156	47525414		hypothetical protein GBAA0156 [Bacillus ...	496	Conserved;	Phase 3: June 2008	2KQ1	6.7%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02746 (show subtarget assignments)	0	work_stopped	No	GBAA0157	47525415	glmM	phosphoglucosamine mutase [Bacillus anth...	448	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PDK	100%	Bacillus anthracis	Cell envelope	N/A

IDP01677 (show subtarget assignments)	1	soluble	No	GBAA0159	47525416	glmS	D-fructose-6-phosphate amidotransferase ...	600	Drug target motif; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JXA	41.8%	Bacillus anthracis	Central intermediary metabolism	Amino sugars

IDP02226 (show subtarget assignments)	1	crystallized	No	GBAA0164	47525422	yqjI	6-phosphogluconate dehydrogenase [Bacill...	469	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2W8Z	72.3%	Bacillus anthracis	Energy metabolism	Pentose phosphate pathway

IDP01683 (show subtarget assignments)	1	expressed	No	GBAA0187	47525446		oligopeptide ABC transporter, ATP-bindin...	336	Conserved; Drug target functions	Phase 3: June 2008	2ONK	24.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP02367 (show subtarget assignments)	1	soluble	No	GBAA0213	47525471		1-acyl-sn-glycerol-3-phosphate acyltrans...	201	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01695 (show subtarget assignments)	1	expressed	No	GBAA0228	47525485		ABC transporter ATP-binding protein [Bac...	626	Conserved; Drug target functions	Phase 3: June 2008	1YQT	20.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02576 (show subtarget assignments)	1	purified	No	GBAA0246	47525503	murF	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	458	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2AM1	37.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02513 (show subtarget assignments)	1	soluble	No	GBAA0258	47525517		hypothetical protein GBAA0258 [Bacillus ...	157	Conserved;	Phase 3: June 2008	1FL9	30.6%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01702 (show subtarget assignments)	1	soluble	No	GBAA0261	47525520	gcP	O-sialoglycoprotein endopeptidase [Bacil...	338	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2IVN	35.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02560 (show subtarget assignments)	1	cloned	No	GBAA0268	47777798	guaA	bifunctional GMP synthase/glutamine amid...	512	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GPM	52.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04659 (show subtarget assignments)	1	soluble	No	GBAA0272	47525531		sensor histidine kinase [Bacillus anthra...	501	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04660 (show subtarget assignments)	1	expressed	No	GBAA0286	47777799		sensor histidine kinase, putative [Bacil...	314	putative drug target function;	Phase 4: April 2009	2C2A	24.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01906 (show subtarget assignments)	1	soluble	No	GBAA0294	47525557	purL	phosphoribosylformylglycinamidine syntha...	739	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3AC6	46.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02568 (show subtarget assignments)	1	cloned	No	GBAA0295	47525558	purF	amidophosphoribosyltransferase [Bacillus...	471	Drug target motif; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AO0	69.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02239 (show subtarget assignments)	1	expressed	No	GBAA0299	47525562	purD	phosphoribosylamine--glycine ligase [Bac...	423	Conserved; Drug target functions	Phase 3: June 2008	2YRW	64.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02716 (show subtarget assignments)	1	cloned	No	GBAA0325	47525592	gabT	4-aminobutyrate aminotransferase [Bacill...	454	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1SF2	45.2%	Bacillus anthracis	Central intermediary metabolism	Other

IDP01710 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA0371	47525642		glycosyl hydrolase family protein [Bacil...	554	Conserved; Drug target functions	Phase 3: June 2008	2ZE0	67%	Bacillus anthracis	Energy metabolism	Sugars

IDP01934 (show subtarget assignments)	1	soluble	No	GBAA0385	47525656		chitinase B [Bacillus anthracis str. 'Am...	674	Drug target motif; Drug target functions	Phase 3: June 2008	1ITX	37.4%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01540 (show subtarget assignments)	1	in_pdb 3EC6	No	GBAA0418	47525694		general stress protein 26 [Bacillus anth...	138	CONSERVED	Phase 3: June 2008	3EC6	100%	Bacillus anthracis

IDP02780 (show subtarget assignments)	1	soluble	No	GBAA0507	47525777		NAD-dependent epimerase/dehydratase fami...	321	Conserved; Drug target functions	Phase 3: June 2008	2B69	35.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01627 (show subtarget assignments)	1	cloned	No	GBAA0530	50196914		glutamate synthase, large subunit, putat...	1478	Conserved; Drug target functions	Phase 3: June 2008	1EA0	29.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02280 (show subtarget assignments)	1	in_pdb 3L44	Yes	GBAA0531	47525801	hemL-1	glutamate-1-semialdehyde aminotransferas...	434	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3L44	99.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02005 (show subtarget assignments)	1	cloned	No	GBAA0543	47525816		penicillin-binding domain-containing pro...	258	Drug target homolog; Involved in sporulation;	Phase 3: June 2008	2OQO	36%	Bacillus anthracis	Unknown function	General

IDP02549 (show subtarget assignments)	1	purified	No	GBAA0547	47525820		RNA methyltransferase [Bacillus anthraci...	162	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3L8U	51.2%	Bacillus anthracis	Protein synthesis	tRNA and rRNA base modification

IDP02494 (show subtarget assignments)	1	cloned	No	GBAA0550	47525823		hypothetical protein GBAA0550 [Bacillus ...	631	Drug target motif; Conserved;	Phase 3: June 2008			Bacillus anthracis	Hypothetical proteins	Conserved

IDP02298 (show subtarget assignments)	1	soluble	No	GBAA0555	47525828		collagenase,putative [Bacillus anthracis...	965	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	2Y3U	39.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04661 (show subtarget assignments)	1	expressed	No	GBAA0572	47777831		sensor histidine kinase [Bacillus anthra...	416	putative drug target function;	Phase 4: April 2009	2C2A	16.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04352 (show subtarget assignments)	1	soluble	No	GBAA0584	47525859		sensor histidine kinase [Bacillus anthra...	487	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	17%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02314 (show subtarget assignments)	1	cloned	No	GBAA0599	47525877		neutral protease [Bacillus anthracis str...	566	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1NPC	53%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02640 (show subtarget assignments)	1	purified	No	GBAA0609	47525887	aspA	aspartate ammonia-lyase [Bacillus anthra...	477	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1J3U	70.6%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02641 (show subtarget assignments)	1	purified	No	GBAA0640	47525919		amino acid ABC transporter amino acid-bi...	276	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2V25	33.3%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP04662 (show subtarget assignments)	1	cloned	No	GBAA0650	47525929		sensor histidine kinase [Bacillus anthra...	463	putative drug target function;	Phase 4: April 2009	2C2A	17.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02304 (show subtarget assignments)	1	cloned	No	GBAA0703	47525984	qoxA	quinol oxidase, subunit II [Bacillus ant...	291	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FFT	33.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02196 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA0734	47526018	thiD-1	phosphomethylpyrimidine kinase [Bacillus...	270	Conserved; Drug target functions	Phase 3: June 2008	2I5B	48.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP02499 (show subtarget assignments)	1	in_pdb 3I3O 3IJR	No	GBAA0748	47526031		short chain dehydrogenase [Bacillus anth...	288	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3I3O	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01782 (show subtarget assignments)	1	expressed	No	GBAA0752	47526035	scrK	fructokinase [Bacillus anthracis str. 'A...	313	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3EWM	33.8%	Bacillus anthracis	Energy metabolism	Sugars

IDP01795 (show subtarget assignments)	1	expressed	No	GBAA0792	47526077	celA-1	PTS system, cellobiose-specific IIB comp...	101	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41.6%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01792 (show subtarget assignments)	1	expressed	No	GBAA0866	47777865	alsS	acetolactate synthase [Bacillus anthraci...	562	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1OZF	50.7%	Bacillus anthracis	Energy metabolism	Fermentation

IDP02263 (show subtarget assignments)	1	in_pdb 3U7I	Yes	GBAA0966	47526249		hypothetical protein GBAA0966 [Bacillus ...	220	Conserved; Essential;	Phase 3: June 2008	3U7I	100%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02267 (show subtarget assignments)	1	soluble	No	GBAA0987	47526266		hypothetical protein GBAA0987 [Bacillus ...	66	Conserved;	Phase 3: June 2008			Bacillus anthracis	Hypothetical proteins	Conserved

IDP04664 (show subtarget assignments)	1	purified	No	GBAA0996	47526275		sensor histidine kinase/response regulat...	896	putative drug target function;	Phase 4: April 2009	2C2A	10.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01794 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1026	47526305	glpK	glycerol kinase [Bacillus anthracis str....	496	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3G25	75%	Bacillus anthracis	Energy metabolism	Other

IDP02451 (show subtarget assignments)	1	in_pdb 3IMI	No	GBAA1047	47526323		HIT family protein [Bacillus anthracis s...	144	Drug target motif; Involved in sporulation;	Phase 3: June 2008	3IMI	100%	Bacillus anthracis	Unknown function	General

IDP04665 (show subtarget assignments)	1	purified	No	GBAA1118	47526389		sensor histidine kinase [Bacillus anthra...	580	putative drug target function;	Phase 4: April 2009	2C2A	11.4%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02485
(show subtarget assignments)

1

cloned

No

FTT1539c

56708571

hypothetical protein FTT1539c [Francisel...

476

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP02498
(show subtarget assignments)

1

cloned

No

FTT1556c

56708584

lepB

signal peptidase I [Francisella tularens...

287

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1B12

33.4%

Francisella tularensis

Protein fate

Protein and peptide secretion and trafficking

IDP02492
(show subtarget assignments)

1

crystallized

No

FTT1559c

56708586

proC

pyrroline-5-carboxylate reductase [Franc...

274

Conserved; Drug target functions

Phase 3: June 2008

3TRI

37.6%

Francisella tularensis

Amino acid biosynthesis

Glutamate family

IDP02624
(show subtarget assignments)

1

soluble

No

FTT1562

56708589

ispA

geranyltranstransferase [Francisella tul...

293

Conserved; Drug target functions

Phase 3: June 2008

2FOR

40.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01633
(show subtarget assignments)

1

soluble

No

FTT1569c

56708595

lpxA

UDP-N-acetylglucosamine acyltransferase ...

259

Conserved; Drug target functions

Phase 3: June 2008

1LXA

43.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01632
(show subtarget assignments)

1

cloned

No

FTT1571c

56708597

lpxD

UDP-3-O-[3-hydroxymyristoyl] glucosamine...

337

Drug Target

Phase 3: June 2008

3EH0

45.1%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02240
(show subtarget assignments)

1

cloned

No

FTT1572c

56708598

ompH

outer membrane protein OmpH [Francisella...

167

Drug Target

Phase 3: June 2008

1SG2

23.4%

Francisella tularensis

Cell envelopeMobile and extrachromosomal element functions

OtherProphage functions

IDP02504
(show subtarget assignments)

1

purified

No

FTT1578c

56708604

ung

uracil-DNA glycosylase [Francisella tula...

220

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1EUG

58.6%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP02526
(show subtarget assignments)

1

cloned

No

FTT1600c

56708620

fumA

fumerate hydratase [Francisella tularens...

504

Drug Target

Phase 3: June 2008

2ISB

13.7%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02672
(show subtarget assignments)

1

cloned

No

FTT1602

56708622

hypothetical protein FTT1602 [Francisell...

114

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelopeUnknown function

OtherGeneral

IDP01607
(show subtarget assignments)

1

cloned

No

FTT1608

56708628

ABC transporter, ATP-binding protein [Fr...

267

Conserved; Drug target functions

Phase 3: June 2008

3DHW

30%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02678
(show subtarget assignments)

1

cloned

No

FTT1653

56708665

hypothetical protein FTT1653 [Francisell...

135

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP02512
(show subtarget assignments)

1

soluble

No

FTT1663

56708674

carA

carbamoyl phosphate synthase small subun...

388

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1BXR

48.5%

Francisella tularensis

N/A

IDP01692
(show subtarget assignments)

1

cloned

No

FTT1671

56708681

ribD

riboflavin biosynthesis protein ribD [Fr...

355

Conserved; Drug target functions

Phase 3: June 2008

2B3Z

37.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02186
(show subtarget assignments)

1

soluble

No

FTT1672

56708682

ribB

riboflavin synthase subunit alpha [Franc...

201

Conserved; Drug target functions

Phase 3: June 2008

1KZL

35.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00332
(show subtarget assignments)

1

purified

No

FTT1673

56708683

ribA

riboflavin biosynthesis protein ribA/GTP...

403

Drug Target Function

Phase 2: March 2008

1G57

27%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02530
(show subtarget assignments)

1

soluble

No

FTT1674

56708684

ribH

riboflavin synthase beta subunit (6,7-di...

147

Conserved; Drug target functions

Phase 3: June 2008

1RVV

45.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01652
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1695

56708704

groES

co-chaperonin GroES [Francisella tularen...

95

Conserved; Drug target functions

Phase 3: June 2008

1AON

56.8%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP02516
(show subtarget assignments)

1

purified

No

FTT1696

56708705

groEL

chaperonin GroEL [Francisella tularensis...

544

Conserved; Drug target functions

Phase 3: June 2008

1AON

73.3%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP04656
(show subtarget assignments)

1

cloned

No

FTT1720c

56708726

purL

phosphoribosylformylglycinamidine syntha...

1290

conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04657
(show subtarget assignments)

1

expressed

No

FTT1721c

56708727

purF

amidophosphoribosyltransferase [Francise...

496

conserved gene; putative drug target function;

Phase 4: April 2009

1ECB

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01790
(show subtarget assignments)

1

purified

No

FTT1731c

56708736

obgE

GTPase ObgE [Francisella tularensis subs...

334

Drug Target

Phase 3: June 2008

1UDX

45.5%

Francisella tularensis

Unknown function

General

IDP04658
(show subtarget assignments)

1

purified

No

FTT1736c

56708739

kdpD

two component sensor protein kdpD [Franc...

893

conserved gene;

Phase 4: April 2009

2R8R

11.4%

Francisella tularensis

IDP02538
(show subtarget assignments)

1

soluble

No

FTT1746

56708744

peptidase [Francisella tularensis subsp....

307

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3RST

23.1%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04045
(show subtarget assignments)

1

soluble

No

FTT1747

56708745

outer membrane protein [Francisella tula...

191

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Francisella tularensis

IDP01739
(show subtarget assignments)

1

in_pdb
3KHY

No

FTT1753

56708751

tdcD

propionate kinase [Francisella tularensi...

384

Conserved; Drug target functions

Phase 3: June 2008

3KHY

100%

Francisella tularensis

Energy metabolism

Fermentation

IDP01848
(show subtarget assignments)

1

cloned

No

FTT1754

56708752

pta

phosphate acetyltransferase [Francisella...

698

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1TD9

19.9%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP01625
(show subtarget assignments)

1

expressed

No

FTT1761

56708756

hypothetical protein FTT1761 [Francisell...

239

Drug Target

Phase 3: June 2008

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP01812
(show subtarget assignments)

1

cloned

No

FTT1764c

56708759

ferredoxin [Francisella tularensis subsp...

107

Conserved; Drug target functions

Phase 3: June 2008

1A6L

64.5%

Francisella tularensis

Energy metabolism

Electron transport

IDP04418
(show subtarget assignments)

1

purified

No

FTT1767c

56708762

purT

phosphoribosylglycinamide formyltransfer...

386

conserved gene; putative drug target function;

Phase 4: April 2009

1EYZ

53.4%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02556
(show subtarget assignments)

1

soluble

No

FTT1769c

56708764

clpB

ClpB protein [Francisella tularensis sub...

859

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1QVR

55.3%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01866
(show subtarget assignments)

1

crystallized

No

FTT1772c

56708766

trpA

tryptophan synthase subunit alpha [Franc...

269

Drug Target

Phase 3: June 2008

3NAV

61%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP02402
(show subtarget assignments)

1

purified

No

FTT1778c

56708771

hypothetical protein FTT1778c [Francisel...

130

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP01667
(show subtarget assignments)

1

expressed

No

FTT1782c

56708774

yjjK

putative ABC transporter ATP-binding pro...

559

Conserved; Drug target functions

Phase 3: June 2008

1YQT

27.3%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP04077
(show subtarget assignments)

1

crystallized

No

FTT1793c

56708781

pepN

aminopeptidase N [Francisella tularensis...

864

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2DQ6

48.9%

Francisella tularensis

IDP01871
(show subtarget assignments)

1

cloned

No

FTT1795c

56708783

trpC

bifunctional indole-3-glycerol phosphate...

453

Conserved; Drug target functions

Phase 3: June 2008

1PII

56.1%

Francisella tularensis

Amino acid biosynthesisFatty acid and phospholipid metabolism

Aromatic amino acid familyHistidine family,Biosynthesis

IDP01878
(show subtarget assignments)

1

cloned

No

FTT1797c

56708785

msrA2

peptide methionine sulfoxide reductase m...

229

Drug Target

Phase 3: June 2008

3PIN

28.4%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP00342
(show subtarget assignments)

1

cloned

No

FTT1802c

56708788

trpE

anthranilate synthase component I

514

Drug Target Function

Phase 2: March 2008

1I1Q

51.1%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP02405
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1803c

56708789

trpR

trp operon repressor [Francisella tulare...

95

Drug Target

Phase 3: June 2008

1CO0

30.5%

Francisella tularensis

Amino acid biosynthesisRegulatory functions

Aromatic amino acid familyDNA interactions

IDP01879
(show subtarget assignments)

1

cloned

No

FTT1804c

56708790

rng

ribonuclease G [Francisella tularensis s...

498

Conserved; Drug target functions

Phase 3: June 2008

2BX2

31.9%

Francisella tularensis

Cellular processesTranscription

Cell divisionRNA processing

IDP91836
(show subtarget assignments)

8

selected

No

GALLO_0038

288904261

Cro/CI family transcriptional regulator ...

299

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus gallolyticus

IDP91836
(show subtarget assignments)

8

selected

No

GALLO_0038

288904261

Cro/CI family transcriptional regulator ...

299

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus gallolyticus

IDP01881
(show subtarget assignments)

1

cloned

No

GBAA0009

47525265

dacA

D-alanyl-D-alanine carboxypeptidase [Bac...

435

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02296
(show subtarget assignments)

1

crystallized

No

GBAA0020

47525275

hypothetical protein GBAA0020 [Bacillus ...

109

Conserved; Involved in sporulation;

Phase 3: June 2008

1YBX

55.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01668
(show subtarget assignments)

1

soluble

No

GBAA0060

47525314

hypothetical protein GBAA0060 [Bacillus ...

160

Essential;

Phase 3: June 2008

2K4K

29.4%

Bacillus anthracis

Unknown function

General

IDP01874
(show subtarget assignments)

1

cloned

No

GBAA0062

47525316

hypothetical protein GBAA0062 [Bacillus ...

476

Conserved;

Phase 3: June 2008

3A2K

46.6%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01892
(show subtarget assignments)

1

in_pdb
3HVU
3KB8
3H83

No

GBAA0063

47525317

hpt-1

hypoxanthine-guanine phosphoribosyltrans...

180

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3H83

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP02213
(show subtarget assignments)

1

expressed

No

GBAA0068

47525322

pabB

para-aminobenzoate synthase component I ...

465

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1QDL

37.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01875
(show subtarget assignments)

1

expressed

No

GBAA0069

47525323

pabA-1

para-aminobenzoate/anthranilate synthase...

195

Conserved; Essential; Drug target functions

Phase 3: June 2008

1QDL

45.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02260
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA0072

47777774

folB

dihydroneopterin aldolase [Bacillus anth...

120

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1DHN

43.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01877
(show subtarget assignments)

1

crystallized

No

GBAA0080

47525336

negative regulator of genetic competence...

811

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PXI

80.1%

Bacillus anthracis

Cellular processes

DNA transformation

IDP02564
(show subtarget assignments)

1

purified

No

GBAA0084

47525340

ispD

2-C-methyl-D-erythritol 4-phosphate cyti...

226

Conserved; Drug target functions

Phase 3: June 2008

1W77

36.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02535
(show subtarget assignments)

1

expressed

No

GBAA0088

47525343

cysE

serine O-acetyltransferase [Bacillus ant...

221

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3GVD

36.2%

Bacillus anthracis

Amino acid biosynthesis

Serine family

IDP01876
(show subtarget assignments)

1

cloned

No

GBAA0095

47525349

secE

preprotein translocase subunit SecE [Bac...

59

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DIN

33.9%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP02148
(show subtarget assignments)

1

cloned

No

GBAA0133

47525389

infA

translation initiation factor IF-1 [Baci...

72

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AH9

72.2%

Bacillus anthracis

Protein synthesis

Translation factors

IDP01670
(show subtarget assignments)

1

cloned

No

GBAA0156

47525414

hypothetical protein GBAA0156 [Bacillus ...

496

Conserved;

Phase 3: June 2008

2KQ1

6.7%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02746
(show subtarget assignments)

0

work_stopped

No

GBAA0157

47525415

glmM

phosphoglucosamine mutase [Bacillus anth...

448

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PDK

100%

Bacillus anthracis

Cell envelope

N/A

IDP01677
(show subtarget assignments)

1

soluble

No

GBAA0159

47525416

glmS

D-fructose-6-phosphate amidotransferase ...

600

Drug target motif; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JXA

41.8%

Bacillus anthracis

Central intermediary metabolism

Amino sugars

IDP02226
(show subtarget assignments)

1

crystallized

No

GBAA0164

47525422

yqjI

6-phosphogluconate dehydrogenase [Bacill...

469

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2W8Z

72.3%

Bacillus anthracis

Energy metabolism

Pentose phosphate pathway

IDP01683
(show subtarget assignments)

1

expressed

No

GBAA0187

47525446

oligopeptide ABC transporter, ATP-bindin...

336

Conserved; Drug target functions

Phase 3: June 2008

2ONK

24.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP02367
(show subtarget assignments)

1

soluble

No

GBAA0213

47525471

1-acyl-sn-glycerol-3-phosphate acyltrans...

201

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01695
(show subtarget assignments)

1

expressed

No

GBAA0228

47525485

ABC transporter ATP-binding protein [Bac...

626

Conserved; Drug target functions

Phase 3: June 2008

1YQT

20.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02576
(show subtarget assignments)

1

purified

No

GBAA0246

47525503

murF

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

458

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2AM1

37.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02513
(show subtarget assignments)

1

soluble

No

GBAA0258

47525517

hypothetical protein GBAA0258 [Bacillus ...

157

Conserved;

Phase 3: June 2008

1FL9

30.6%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01702
(show subtarget assignments)

1

soluble

No

GBAA0261

47525520

gcP

O-sialoglycoprotein endopeptidase [Bacil...

338

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2IVN

35.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02560
(show subtarget assignments)

1

cloned

No

GBAA0268

47777798

guaA

bifunctional GMP synthase/glutamine amid...

512

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GPM

52.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04659
(show subtarget assignments)

1

soluble

No

GBAA0272

47525531

sensor histidine kinase [Bacillus anthra...

501

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04660
(show subtarget assignments)

1

expressed

No

GBAA0286

47777799

sensor histidine kinase, putative [Bacil...

314

putative drug target function;

Phase 4: April 2009

2C2A

24.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01906
(show subtarget assignments)

1

soluble

No

GBAA0294

47525557

purL

phosphoribosylformylglycinamidine syntha...

739

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3AC6

46.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02568
(show subtarget assignments)

1

cloned

No

GBAA0295

47525558

purF

amidophosphoribosyltransferase [Bacillus...

471

Drug target motif; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AO0

69.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02239
(show subtarget assignments)

1

expressed

No

GBAA0299

47525562

purD

phosphoribosylamine--glycine ligase [Bac...

423

Conserved; Drug target functions

Phase 3: June 2008

2YRW

64.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02716
(show subtarget assignments)

1

cloned

No

GBAA0325

47525592

gabT

4-aminobutyrate aminotransferase [Bacill...

454

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1SF2

45.2%

Bacillus anthracis

Central intermediary metabolism

Other

IDP01710
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA0371

47525642

glycosyl hydrolase family protein [Bacil...

554

Conserved; Drug target functions

Phase 3: June 2008

2ZE0

67%

Bacillus anthracis

Energy metabolism

Sugars

IDP01934
(show subtarget assignments)

1

soluble

No

GBAA0385

47525656

chitinase B [Bacillus anthracis str. 'Am...

674

Drug target motif; Drug target functions

Phase 3: June 2008

1ITX

37.4%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01540
(show subtarget assignments)

1

in_pdb
3EC6

No

GBAA0418

47525694

general stress protein 26 [Bacillus anth...

138

CONSERVED

Phase 3: June 2008

3EC6

100%

Bacillus anthracis

IDP02780
(show subtarget assignments)

1

soluble

No

GBAA0507

47525777

NAD-dependent epimerase/dehydratase fami...

321

Conserved; Drug target functions

Phase 3: June 2008

2B69

35.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01627
(show subtarget assignments)

1

cloned

No

GBAA0530

50196914

glutamate synthase, large subunit, putat...

1478

Conserved; Drug target functions

Phase 3: June 2008

1EA0

29.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02280
(show subtarget assignments)

1

in_pdb
3L44

Yes

GBAA0531

47525801

hemL-1

glutamate-1-semialdehyde aminotransferas...

434

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3L44

99.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02005
(show subtarget assignments)

1

cloned

No

GBAA0543

47525816

penicillin-binding domain-containing pro...

258

Drug target homolog; Involved in sporulation;

Phase 3: June 2008

2OQO

36%

Bacillus anthracis

Unknown function

General

IDP02549
(show subtarget assignments)

1

purified

No

GBAA0547

47525820

RNA methyltransferase [Bacillus anthraci...

162

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3L8U

51.2%

Bacillus anthracis

Protein synthesis

tRNA and rRNA base modification

IDP02494
(show subtarget assignments)

1

cloned

No

GBAA0550

47525823

hypothetical protein GBAA0550 [Bacillus ...

631

Drug target motif; Conserved;

Phase 3: June 2008

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02298
(show subtarget assignments)

1

soluble

No

GBAA0555

47525828

collagenase,putative [Bacillus anthracis...

965

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

2Y3U

39.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04661
(show subtarget assignments)

1

expressed

No

GBAA0572

47777831

sensor histidine kinase [Bacillus anthra...

416

putative drug target function;

Phase 4: April 2009

2C2A

16.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04352
(show subtarget assignments)

1

soluble

No

GBAA0584

47525859

sensor histidine kinase [Bacillus anthra...

487

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

17%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02314
(show subtarget assignments)

1

cloned

No

GBAA0599

47525877

neutral protease [Bacillus anthracis str...

566

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1NPC

53%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02640
(show subtarget assignments)

1

purified

No

GBAA0609

47525887

aspA

aspartate ammonia-lyase [Bacillus anthra...

477

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1J3U

70.6%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02641
(show subtarget assignments)

1

purified

No

GBAA0640

47525919

amino acid ABC transporter amino acid-bi...

276

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2V25

33.3%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP04662
(show subtarget assignments)

1

cloned

No

GBAA0650

47525929

sensor histidine kinase [Bacillus anthra...

463

putative drug target function;

Phase 4: April 2009

2C2A

17.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02304
(show subtarget assignments)

1

cloned

No

GBAA0703

47525984

qoxA

quinol oxidase, subunit II [Bacillus ant...

291

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FFT

33.7%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02196
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA0734

47526018

thiD-1

phosphomethylpyrimidine kinase [Bacillus...

270

Conserved; Drug target functions

Phase 3: June 2008

2I5B

48.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP02499
(show subtarget assignments)

1

in_pdb
3I3O
3IJR

No

GBAA0748

47526031

short chain dehydrogenase [Bacillus anth...

288

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3I3O

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01782
(show subtarget assignments)

1

expressed

No

GBAA0752

47526035

scrK

fructokinase [Bacillus anthracis str. 'A...

313

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3EWM

33.8%

Bacillus anthracis

Energy metabolism

Sugars

IDP01795
(show subtarget assignments)

1

expressed

No

GBAA0792

47526077

celA-1

PTS system, cellobiose-specific IIB comp...

101

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41.6%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01792
(show subtarget assignments)

1

expressed

No

GBAA0866

47777865

alsS

acetolactate synthase [Bacillus anthraci...

562

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1OZF

50.7%

Bacillus anthracis

Energy metabolism

Fermentation

IDP02263
(show subtarget assignments)

1

in_pdb
3U7I

Yes

GBAA0966

47526249

hypothetical protein GBAA0966 [Bacillus ...

220

Conserved; Essential;

Phase 3: June 2008

3U7I

100%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02267
(show subtarget assignments)

1

soluble

No

GBAA0987

47526266

hypothetical protein GBAA0987 [Bacillus ...

66

Conserved;

Phase 3: June 2008

Bacillus anthracis

Hypothetical proteins

Conserved

IDP04664
(show subtarget assignments)

1

purified

No

GBAA0996

47526275

sensor histidine kinase/response regulat...

896

putative drug target function;

Phase 4: April 2009

2C2A

10.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01794
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1026

47526305

glpK

glycerol kinase [Bacillus anthracis str....

496

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3G25

75%

Bacillus anthracis

Energy metabolism

Other

IDP02451
(show subtarget assignments)

1

in_pdb
3IMI

No

GBAA1047

47526323

HIT family protein [Bacillus anthracis s...

144

Drug target motif; Involved in sporulation;

Phase 3: June 2008

3IMI

100%

Bacillus anthracis

Unknown function

General

IDP04665
(show subtarget assignments)

1

purified

No

GBAA1118

47526389

sensor histidine kinase [Bacillus anthra...

580

putative drug target function;

Phase 4: April 2009

2C2A

11.4%

Bacillus anthracis

Regulatory functions

Protein interactions

Targets