Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01020 (show subtarget assignments)	1	expressed	No	STM2110	16765440	wcaF	putative colanic acid biosynthesis acety...	184	Essential Gene	Phase 2: March 2008	3SRT	26.1%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00538 (show subtarget assignments)	1	in_pdb 3GVD	No	YPO0070	16120421	cysE	serine acetyltransferase	273	Drug Target Function	Phase 2: March 2008	3GVD	100%	Yersinia pestis	Amino acid biosynthesis	Serine family

IDP01019 (show subtarget assignments)	0	work_stopped	No	STM0228	16763618	lpxA	UDP-N-acetylglucosamine acyltransferase ...	262	Essential Gene	Phase 2: March 2008	1LXA	93.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00539 (show subtarget assignments)	1	purified	No	YPO2751	16122955	aroC	chorismate synthase	361	Conserved Gene / Pathway	Phase 2: March 2008	1R52	45%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP01018 (show subtarget assignments)	1	expressed	No	STM2894	16766200	invC	ATP synthase SpaL	431	Conserved Gene / Pathway	Phase 2: March 2008	2OBL	38.7%	Salmonella enterica	Transport and binding proteins	Other

IDP00537 (show subtarget assignments)	1	purified	No	YPO3924	16124055	argH	argininosuccinate lyase	457	Conserved Gene / Pathway	Phase 2: March 2008	1TJ7	88.8%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP01017 (show subtarget assignments)	1	expressed	No	STM2854	16766160	hypA	hydrogenase nickel incorporation protein...	118	Conserved Gene / Pathway	Phase 2: March 2008	3A43	24.6%	Salmonella enterica	Protein fate	Protein modification and repair

IDP01016 (show subtarget assignments)	1	cloned	No	STM2792	16766103	gabT	4-aminobutyrate aminotransferase	427	Conserved Gene / Pathway	Phase 2: March 2008	1SF2	88.3%	Salmonella enterica	Central intermediary metabolism	Other

IDP01015 (show subtarget assignments)	0	work_stopped	No	STM2791	16766102	gabD	succinate-semialdehyde dehydrogenase I	482	Conserved Gene / Pathway	Phase 2: March 2008	3JZ4	90%	Salmonella enterica	Central intermediary metabolism	Other

IDP00536 (show subtarget assignments)	1	purified	No	YPO4003	16124128	dppA	periplasmic dipeptide transport protein ...	535	Virulence Associated Factor	Phase 2: March 2008	1DPP	81.5%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01014 (show subtarget assignments)	1	in_crystallization_trials	No	STM2780	16766091	pipB2	secreted effector protein	350	Virulence Associated Factor	Phase 2: March 2008	2LEZ	41.4%	Salmonella enterica	Unknown function	General

IDP01013 (show subtarget assignments)	1	purified	No	STM2670	16765985	aroF	phospho-2-dehydro-3-deoxyheptonate aldol...	356	Conserved Gene / Pathway	Phase 2: March 2008	1GG1	51.4%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP00535 (show subtarget assignments)	1	purified	No	YPO3506	16123652	dacB	D-alanyl-D-alanine carboxypeptidase/endo...	482	Drug Target Function	Phase 2: March 2008	2EX2	77.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00534 (show subtarget assignments)	1	purified	No	YPO3367	16123517	cysG	siroheme synthase	472	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	52.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01012 (show subtarget assignments)	1	purified	No	STM2578	16765898	pdxJ	pyridoxal phosphate biosynthetic protein...	243	Conserved Gene / Pathway	Phase 2: March 2008	1M5W	93.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP01011 (show subtarget assignments)	1	in_pdb 3GBX	Yes	STM2555	16765875	glyA	serine hydroxymethyltransferase	417	Conserved Gene / Pathway	Phase 2: March 2008	3GBX	100%	Salmonella enterica	Amino acid biosynthesis	Serine family

IDP01010 (show subtarget assignments)	1	purified	No	STM2539	16765859	hscA	chaperone protein HscA	616	Conserved Gene / Pathway	Phase 2: March 2008	2KHO	40.9%	Salmonella enterica	Protein fate	Protein folding and stabilization

IDP00533 (show subtarget assignments)	1	purified	No	YPO0158	16120501	cysG	siroheme synthase	470	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	70.2%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01009 (show subtarget assignments)	1	cloned	No	STM2535	16765855	sseB	enhanced serine sensitivity protein	261	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP01008 (show subtarget assignments)	1	soluble	No	STM2533	16765853	sseA	3-mercaptopyruvate sulfurtransferase	280	Conserved Gene / Pathway	Phase 2: March 2008	1URH	79.6%	Salmonella enterica	Cellular processes	Detoxification

IDP01007 (show subtarget assignments)	1	cloned	No	STM2531	16765851	pbpC	penicillin-binding protein 1C	771	Drug Target Function	Phase 2: March 2008	2OLU	21.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00532 (show subtarget assignments)	1	purified	No	YPO2390	16122613	cfa	cyclopropane fatty acyl phospholipid syn...	383	Virulence Associated Factor	Phase 2: March 2008	1TPY	25.6%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01006 (show subtarget assignments)	1	soluble	No	STM2529	16765849		putative anaerobic dimethylsulfoxide red...	209	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	31.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01005 (show subtarget assignments)	1	in_crystallization_trials	No	STM2511	16765831	guaB	inositol-5-monophosphate dehydrogenase	488	Conserved Gene / Pathway	Phase 2: March 2008	3TSB	55.9%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00530 (show subtarget assignments)	1	cloned	No	YPO2736	16122940	ccmC	putative heme exporter protein C	245	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cellular processes	Other

IDP01004 (show subtarget assignments)	1	in_pdb 3G0S	Yes	STM2489	16765809	dapA	dihydrodipicolinate synthase	292	Conserved Gene / Pathway	Phase 2: March 2008	3G0S	100%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP01003 (show subtarget assignments)	1	cloned	No	STM2479	16765799	aegA	putative oxidoreductase Fe-S binding sub...	653	Conserved Gene / Pathway	Phase 2: March 2008	2VDC	29.2%	Salmonella enterica	Central intermediary metabolism	Other

IDP00531 (show subtarget assignments)	1	cloned	No	YPO2737	16122941	ccmD	putative heme exporter protein D	100	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cellular processes	Other

IDP01002 (show subtarget assignments)	1	in_pdb 3ERP	Yes	STM2406	16765732		putative oxidoreductase	332	Essential Gene	Phase 2: March 2008	3ERP	100%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP01001 (show subtarget assignments)	1	soluble	No	STM2405	16765731		indolepyruvate decarboxylase	550	Conserved Gene / Pathway	Phase 2: March 2008	1OVM	66.7%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP01000 (show subtarget assignments)	1	expressed	No	STM2389	16765716	fadI	3-ketoacyl-CoA thiolase	436	Conserved Gene / Pathway	Phase 2: March 2008	1ULQ	35.8%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP00999 (show subtarget assignments)	1	expressed	No	STM2388	16765715	fadJ	multifunctional fatty acid oxidation com...	715	Conserved Gene / Pathway	Phase 2: March 2008	1WDK	35.8%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP00998 (show subtarget assignments)	1	in_crystallization_trials	No	STM2369	16765696	usg	hypothetical protein STM2369	337	Conserved Gene / Pathway	Phase 2: March 2008	2QZ9	46.6%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP00997 (show subtarget assignments)	1	soluble	No	STM2314	16765641		putative chemotaxis signal transduction ...	333	Conserved Gene / Pathway	Phase 2: March 2008	1K68	12%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP00526 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1351	16121631	artI	arginine-binding periplasmic protein 1 p...	243	Conserved Gene / Pathway	Phase 2: March 2008	2Y7I	52.7%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00529 (show subtarget assignments)	1	expressed	No	YPO2734	16122938	ccmA	putative heme exporter protein A	218	Virulence Associated Factor	Phase 2: March 2008	1B0U	27.5%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00528 (show subtarget assignments)	1	expressed	No	YPO0481	16120811	carA	carbamoyl phosphate synthase small subun...	391	Drug Target Function	Phase 2: March 2008	1BXR	84.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00996 (show subtarget assignments)	1	in_crystallization_trials	No	STM2310	16765637	menF	menaquinone-specific isochorismate synth...	431	Drug Target Function	Phase 2: March 2008	2EUA	78.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP00995 (show subtarget assignments)	1	in_pdb 3H02	No	STM2307	16765634	menB	naphthoate synthase	285	Conserved Gene / Pathway	Phase 2: March 2008	3H02	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00527 (show subtarget assignments)	1	purified	No	YPO0129	16120472	bioH	putative biotin biosynthesis protein	258	Drug Target Function	Phase 2: March 2008	1M33	63.6%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00994 (show subtarget assignments)	1	in_pdb 3GC2	No	STM2306	16765633	menC	O-succinylbenzoate synthase	320	Conserved Gene / Pathway	Phase 2: March 2008	3GC2	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00525 (show subtarget assignments)	1	cloned	No	YPMT1.83	16082875	caf1A	putative F1 capsule anchoring protein	833	Virulence Associated Factor	Phase 2: March 2008	3RFZ	35.3%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00993 (show subtarget assignments)	0	work_stopped	No	STM2250	16765578	ccmE	cytochrome c-type biogenesis protein Ccm...	159	Conserved Gene / Pathway	Phase 2: March 2008	1SR3	68.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00992 (show subtarget assignments)	1	soluble	No	STM2227	16765556	yejL	putative cytoplasmic protein	75	Conserved Gene / Pathway	Phase 2: March 2008	2JRX	90.7%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00991 (show subtarget assignments)	1	in_crystallization_trials	No	STM2212	16765541	yeiR	putative cobalamin biosynthetic protein ...	328	Conserved Gene / Pathway	Phase 2: March 2008	1NIJ	18.9%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00524 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0490	16120820	apaH	diadenosine tetraphosphatase	289	Conserved Gene / Pathway	Phase 2: March 2008	2DFJ	73.7%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP00990 (show subtarget assignments)	0	work_stopped	No	STM2193	16765523	folE	GTP cyclohydrolase I	222	Conserved Gene / Pathway	Phase 2: March 2008	1FBX	95.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00989 (show subtarget assignments)	1	purified	No	STM2183	16765513	cdd	cytidine deaminase	294	Conserved Gene / Pathway	Phase 2: March 2008	1AF2	87.4%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP00522 (show subtarget assignments)	1	soluble	No	YPO3423	16123572	ampD	N-acetyl-anhydromuranmyl-L-alanine amida...	183	Conserved Gene / Pathway	Phase 2: March 2008	1J3G	62.3%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00988 (show subtarget assignments)	1	expressed	No	STM2163	16765493	yehX	putative ABC-type proline/glycine betain...	315	Conserved Gene / Pathway	Phase 2: March 2008	1V43	32.4%	Salmonella enterica	Transport and binding proteins	Other

IDP00987 (show subtarget assignments)	1	soluble	No	STM2147	16765476	thiM	hydroxyethylthiazole kinase	265	Conserved Gene / Pathway	Phase 2: March 2008	1C3Q	36.6%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP00523 (show subtarget assignments)	1	in_pdb 3OZH 3RJU	Yes	YPO1224	16121513	ampH	beta-lactamase/D-alanine carboxypeptidas...	388	Conserved Gene / Pathway	Phase 2: March 2008	3OZH	89.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00986 (show subtarget assignments)	1	cloned	No	STM2106	16765436	wcaI	predicted glycosyl transferase	407	Drug Target Function	Phase 2: March 2008			Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00521 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3180	16123342	thiL	thiamine monophosphate kinase	329	Conserved Gene / Pathway	Phase 2: March 2008	3MCQ	41.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP00985 (show subtarget assignments)	1	soluble	No	STM2076	16765406	hisA	1-(5-phosphoribosyl)-5-[(5-phosphoribosy...	245	Conserved Gene / Pathway	Phase 2: March 2008	2Y85	35.1%	Salmonella enterica	Amino acid biosynthesis	Histidine family

IDP00984 (show subtarget assignments)	1	in_crystallization_trials	No	STM2073	16765403	hisC	histidinol-phosphate aminotransferase	359	Conserved Gene / Pathway	Phase 2: March 2008	1FG3	88%	Salmonella enterica	Amino acid biosynthesis	Histidine family

IDP00983 (show subtarget assignments)	1	cloned	No	STM2064	16765394	phsB	thiosulfate reductase electron transport...	192	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	37%	Salmonella enterica	Energy metabolism	Electron transport

IDP00520 (show subtarget assignments)	1	in_pdb 3F6M 3FPI	No	YPO3360	16123510	ispF	2-C-methyl-D-erythritol 2,4-cyclodiphosp...	162	Conserved Gene / Pathway	Phase 2: March 2008	3F6M	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00982 (show subtarget assignments)	1	soluble	No	STM2062	16765392	dacD	D-alanyl-D-alanine carboxypeptidase	390	Drug Target Function	Phase 2: March 2008	1NZO	45.1%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00981 (show subtarget assignments)	1	in_crystallization_trials	No	STM2052	16765382	pduQ	propanol dehydrogenase	370	Conserved Gene / Pathway	Phase 2: March 2008	3OWO	35.3%	Salmonella enterica	Energy metabolism	Fermentation

IDP00519 (show subtarget assignments)	1	cloned	No	YPO3446	16123594	argI	ornithine carbamoyltransferase subunit I...	335	Conserved Gene / Pathway	Phase 2: March 2008	1AKM	79.1%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP00518 (show subtarget assignments)	1	cloned	No	YPO1566	16121836		putative hydrolase	280	Virulence Associated Factor	Phase 2: March 2008	3QDF	31.8%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00980 (show subtarget assignments)	1	in_crystallization_trials	No	STM1970	16765308	fliG	flagellar motor switch protein G	331	Conserved Gene / Pathway	Phase 2: March 2008	3HJL	28.7%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP00979 (show subtarget assignments)	1	purified	No	STM1953	16765291	yedO	D-cysteine desulfhydrase	328	Conserved Gene / Pathway	Phase 2: March 2008	1J0A	38.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP00978 (show subtarget assignments)	1	purified	No	STM1951	16765289	yecC	putative amino-acid ABC transporter ATP-...	250	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	54.8%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00517 (show subtarget assignments)	1	soluble	No	YPMT1.71	16082863		hypothetical protein YPMT1.71	328	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Cellular processes	Cell division

IDP00977 (show subtarget assignments)	1	expressed	No	STM1932	16765273	ftnB	ferritin-like protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1EUM	33.5%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00976 (show subtarget assignments)	1	in_crystallization_trials	No	STM1879	16765221	ptrB	protease 2	683	Drug Target Function	Phase 2: March 2008	2XE4	37.6%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00975 (show subtarget assignments)	1	cloned	No	STM1815	16765156	minD	cell division inhibitor MinD	270	Conserved Gene / Pathway	Phase 2: March 2008	3Q9L	93.3%	Salmonella enterica	Cellular processes	Cell division

IDP00516 (show subtarget assignments)	1	purified	No	YPO4022	16124145		putative iron transport protein	317	Conserved Gene / Pathway	Phase 2: March 2008	3GFV	34.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00974 (show subtarget assignments)	1	in_crystallization_trials	No	STM1775	16765116	hemK	N5-glutamine S-adenosyl-L-methionine-dep...	277	Essential Gene	Phase 2: March 2008	1T43	76.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00973 (show subtarget assignments)	1	purified	No	STM1756	16765100	purU	formyltetrahydrofolate deformylase	280	Conserved Gene / Pathway	Phase 2: March 2008	3O1L	42.7%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00514 (show subtarget assignments)	1	selected	No	YPO3721	16123859		hemolysin	1635	Conserved Gene / Pathway	Phase 2: March 2008	3FY3	9%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00972 (show subtarget assignments)	1	expressed	No	STM1743	16765087	oppD	oligopeptide transporter ATP-binding com...	335	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	25.7%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00971 (show subtarget assignments)	1	in_pdb 3IAH	Yes	STM1717	16765061	yciK	short chain dehydrogenase	253	Conserved Gene / Pathway	Phase 2: March 2008	3IAH	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP00515 (show subtarget assignments)	1	cloned	No	YPO3922	16124053		hemophore HasA	205	Virulence Associated Factor	Phase 2: March 2008	1B2V	29.8%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP00970 (show subtarget assignments)	1	soluble	No	STM1682	16765025	tpx	thiol peroxidase	168	Conserved Gene / Pathway	Phase 2: March 2008	1QXH	87.5%	Salmonella enterica	Cellular processes	Detoxification

IDP00969 (show subtarget assignments)	1	purified	No	STM1597	161353598	ydcW	putative aldehyde dehydrogenase	474	Conserved Gene / Pathway	Phase 2: March 2008	1WNB	83.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00968 (show subtarget assignments)	1	in_pdb 3M07	No	STM1560	16764904		putative alpha amylase	594	Essential Gene	Phase 2: March 2008	3M07	100%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00967 (show subtarget assignments)	1	in_crystallization_trials	No	STM1559	16764903		putative glycosyl hydrolase	842	Essential Gene	Phase 2: March 2008	3HJE	31.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00513 (show subtarget assignments)	1	cloned	No	YPO3674	16123817		putative insecticidal toxin	1011	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00966 (show subtarget assignments)	1	expressed	No	STM1552	16764897		putative cytoplasmic protein	302	Essential Gene	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00965 (show subtarget assignments)	1	purified	No	STM1463	16764811	add	adenosine deaminase	333	Conserved Gene / Pathway	Phase 2: March 2008	1NDV	33.8%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP00512 (show subtarget assignments)	1	cloned	No	YPO2244	16122472		electron transport complex protein RnfC ...	620	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Unclassified	Role category not yet assigned

IDP00511 (show subtarget assignments)	1	in_pdb 3RPE	No	YPO0670	16120995	mdaB	putative modulator of drug activity	194	Conserved Gene / Pathway	Phase 2: March 2008	3RPE	100%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00964 (show subtarget assignments)	0	work_stopped	No	STM1439	16764787	ydhF	putative aldo/keto reductase	298	Conserved Gene / Pathway	Phase 2: March 2008	1OG6	88.9%	Salmonella enterica	Unknown function	General

IDP00963 (show subtarget assignments)	1	in_crystallization_trials	No	STM1436	16764784	nemA	N-ethylmaleimide reductase, FMN-linked	365	Conserved Gene / Pathway	Phase 2: March 2008	3P62	87.4%	Salmonella enterica	Central intermediary metabolism	Other

IDP00510 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3572	16123716		hypothetical protein YPO3572	207	Virulence Associated Factor	Phase 2: March 2008	2QGU	30%	Yersinia pestis	Cell envelope	Other

IDP00962 (show subtarget assignments)	1	cloned	No	STM1427	16764775	cfa	cyclopropane fatty acyl phospholipid syn...	382	Drug Target Function	Phase 2: March 2008	1KP9	26.7%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00509 (show subtarget assignments)	1	in_pdb 3RY3	No	YPO2660	16122866		putative solute-binding protein	525	Conserved Gene / Pathway	Phase 2: March 2008	3RY3	100%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00961 (show subtarget assignments)	1	expressed	No	STM1385	16764735	ttrB	tetrathionate reductase complex subunit ...	250	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	34.4%	Salmonella enterica	Energy metabolism	Electron transport

IDP00960 (show subtarget assignments)	1	in_pdb 3HMQ	No	STM1310	16764661	nadE	NAD synthetase	275	Drug Target Function	Phase 2: March 2008	3HMQ	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00959 (show subtarget assignments)	1	soluble	No	STM1303	16764654	argD	bifunctional succinylornithine transamin...	408	Conserved Gene / Pathway	Phase 2: March 2008	2PB0	60.8%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP00508 (show subtarget assignments)	1	expressed	No	YPO1315	16121597		putative hydrolase	216	Conserved Gene / Pathway	Phase 2: March 2008	3FVV	35.2%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00958 (show subtarget assignments)	1	soluble	No	STM1218	16764573	lolD	lipoprotein transporter ATP-binding subu...	233	Conserved Gene / Pathway	Phase 2: March 2008	2PCJ	43.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00957 (show subtarget assignments)	0	work_stopped	No	STM1202	16764557	ycfH	predicted metallodependent hydrolase	265	Conserved Gene / Pathway	Phase 2: March 2008	1YIX	92.8%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP00506 (show subtarget assignments)	1	expressed	No	YPO2491	16122712		putative hemolysin activator protein	562	Conserved Gene / Pathway	Phase 2: March 2008	2QDZ	21.9%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00956 (show subtarget assignments)	1	in_pdb 3H0P	No	STM1194	16764549	fabD	acyl carrier protein S-malonyltransferas...	309	potential drug target / Essential Gene	Phase 2: March 2008	3H0P	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00955 (show subtarget assignments)	1	cloned	No	STM1192	16764547	plsX	fatty acid/phospholipid synthesis protei...	359	Conserved Gene / Pathway	Phase 2: March 2008	1U7N	36.5%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00507 (show subtarget assignments)	1	purified	No	YPO2511	16122732		hypothetical protein YPO2511	375	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cell envelope	Other

IDP01020
(show subtarget assignments)

1

expressed

No

STM2110

16765440

wcaF

putative colanic acid biosynthesis acety...

184

Essential Gene

Phase 2: March 2008

3SRT

26.1%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00538
(show subtarget assignments)

1

in_pdb
3GVD

No

YPO0070

16120421

cysE

serine acetyltransferase

273

Drug Target Function

Phase 2: March 2008

3GVD

100%

Yersinia pestis

Amino acid biosynthesis

Serine family

IDP01019
(show subtarget assignments)

0

work_stopped

No

STM0228

16763618

lpxA

UDP-N-acetylglucosamine acyltransferase ...

262

Essential Gene

Phase 2: March 2008

1LXA

93.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00539
(show subtarget assignments)

1

purified

No

YPO2751

16122955

aroC

chorismate synthase

361

Conserved Gene / Pathway

Phase 2: March 2008

1R52

45%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP01018
(show subtarget assignments)

1

expressed

No

STM2894

16766200

invC

ATP synthase SpaL

431

Conserved Gene / Pathway

Phase 2: March 2008

2OBL

38.7%

Salmonella enterica

Transport and binding proteins

Other

IDP00537
(show subtarget assignments)

1

purified

No

YPO3924

16124055

argH

argininosuccinate lyase

457

Conserved Gene / Pathway

Phase 2: March 2008

1TJ7

88.8%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP01017
(show subtarget assignments)

1

expressed

No

STM2854

16766160

hypA

hydrogenase nickel incorporation protein...

118

Conserved Gene / Pathway

Phase 2: March 2008

3A43

24.6%

Salmonella enterica

Protein fate

Protein modification and repair

IDP01016
(show subtarget assignments)

1

cloned

No

STM2792

16766103

gabT

4-aminobutyrate aminotransferase

427

Conserved Gene / Pathway

Phase 2: March 2008

1SF2

88.3%

Salmonella enterica

Central intermediary metabolism

Other

IDP01015
(show subtarget assignments)

0

work_stopped

No

STM2791

16766102

gabD

succinate-semialdehyde dehydrogenase I

482

Conserved Gene / Pathway

Phase 2: March 2008

3JZ4

90%

Salmonella enterica

Central intermediary metabolism

Other

IDP00536
(show subtarget assignments)

1

purified

No

YPO4003

16124128

dppA

periplasmic dipeptide transport protein ...

535

Virulence Associated Factor

Phase 2: March 2008

1DPP

81.5%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01014
(show subtarget assignments)

1

in_crystallization_trials

No

STM2780

16766091

pipB2

secreted effector protein

350

Virulence Associated Factor

Phase 2: March 2008

2LEZ

41.4%

Salmonella enterica

Unknown function

General

IDP01013
(show subtarget assignments)

1

purified

No

STM2670

16765985

aroF

phospho-2-dehydro-3-deoxyheptonate aldol...

356

Conserved Gene / Pathway

Phase 2: March 2008

1GG1

51.4%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP00535
(show subtarget assignments)

1

purified

No

YPO3506

16123652

dacB

D-alanyl-D-alanine carboxypeptidase/endo...

482

Drug Target Function

Phase 2: March 2008

2EX2

77.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00534
(show subtarget assignments)

1

purified

No

YPO3367

16123517

cysG

siroheme synthase

472

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

52.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01012
(show subtarget assignments)

1

purified

No

STM2578

16765898

pdxJ

pyridoxal phosphate biosynthetic protein...

243

Conserved Gene / Pathway

Phase 2: March 2008

1M5W

93.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP01011
(show subtarget assignments)

1

in_pdb
3GBX

Yes

STM2555

16765875

glyA

serine hydroxymethyltransferase

417

Conserved Gene / Pathway

Phase 2: March 2008

3GBX

100%

Salmonella enterica

Amino acid biosynthesis

Serine family

IDP01010
(show subtarget assignments)

1

purified

No

STM2539

16765859

hscA

chaperone protein HscA

616

Conserved Gene / Pathway

Phase 2: March 2008

2KHO

40.9%

Salmonella enterica

Protein fate

Protein folding and stabilization

IDP00533
(show subtarget assignments)

1

purified

No

YPO0158

16120501

cysG

siroheme synthase

470

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

70.2%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01009
(show subtarget assignments)

1

cloned

No

STM2535

16765855

sseB

enhanced serine sensitivity protein

261

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP01008
(show subtarget assignments)

1

soluble

No

STM2533

16765853

sseA

3-mercaptopyruvate sulfurtransferase

280

Conserved Gene / Pathway

Phase 2: March 2008

1URH

79.6%

Salmonella enterica

Cellular processes

Detoxification

IDP01007
(show subtarget assignments)

1

cloned

No

STM2531

16765851

pbpC

penicillin-binding protein 1C

771

Drug Target Function

Phase 2: March 2008

2OLU

21.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00532
(show subtarget assignments)

1

purified

No

YPO2390

16122613

cfa

cyclopropane fatty acyl phospholipid syn...

383

Virulence Associated Factor

Phase 2: March 2008

1TPY

25.6%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01006
(show subtarget assignments)

1

soluble

No

STM2529

16765849

putative anaerobic dimethylsulfoxide red...

209

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

31.6%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01005
(show subtarget assignments)

1

in_crystallization_trials

No

STM2511

16765831

guaB

inositol-5-monophosphate dehydrogenase

488

Conserved Gene / Pathway

Phase 2: March 2008

3TSB

55.9%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00530
(show subtarget assignments)

1

cloned

No

YPO2736

16122940

ccmC

putative heme exporter protein C

245

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cellular processes

Other

IDP01004
(show subtarget assignments)

1

in_pdb
3G0S

Yes

STM2489

16765809

dapA

dihydrodipicolinate synthase

292

Conserved Gene / Pathway

Phase 2: March 2008

3G0S

100%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP01003
(show subtarget assignments)

1

cloned

No

STM2479

16765799

aegA

putative oxidoreductase Fe-S binding sub...

653

Conserved Gene / Pathway

Phase 2: March 2008

2VDC

29.2%

Salmonella enterica

Central intermediary metabolism

Other

IDP00531
(show subtarget assignments)

1

cloned

No

YPO2737

16122941

ccmD

putative heme exporter protein D

100

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cellular processes

Other

IDP01002
(show subtarget assignments)

1

in_pdb
3ERP

Yes

STM2406

16765732

putative oxidoreductase

332

Essential Gene

Phase 2: March 2008

3ERP

100%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP01001
(show subtarget assignments)

1

soluble

No

STM2405

16765731

indolepyruvate decarboxylase

550

Conserved Gene / Pathway

Phase 2: March 2008

1OVM

66.7%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP01000
(show subtarget assignments)

1

expressed

No

STM2389

16765716

fadI

3-ketoacyl-CoA thiolase

436

Conserved Gene / Pathway

Phase 2: March 2008

1ULQ

35.8%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP00999
(show subtarget assignments)

1

expressed

No

STM2388

16765715

fadJ

multifunctional fatty acid oxidation com...

715

Conserved Gene / Pathway

Phase 2: March 2008

1WDK

35.8%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP00998
(show subtarget assignments)

1

in_crystallization_trials

No

STM2369

16765696

usg

hypothetical protein STM2369

337

Conserved Gene / Pathway

Phase 2: March 2008

2QZ9

46.6%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP00997
(show subtarget assignments)

1

soluble

No

STM2314

16765641

putative chemotaxis signal transduction ...

333

Conserved Gene / Pathway

Phase 2: March 2008

1K68

12%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP00526
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1351

16121631

artI

arginine-binding periplasmic protein 1 p...

243

Conserved Gene / Pathway

Phase 2: March 2008

2Y7I

52.7%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00529
(show subtarget assignments)

1

expressed

No

YPO2734

16122938

ccmA

putative heme exporter protein A

218

Virulence Associated Factor

Phase 2: March 2008

1B0U

27.5%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00528
(show subtarget assignments)

1

expressed

No

YPO0481

16120811

carA

carbamoyl phosphate synthase small subun...

391

Drug Target Function

Phase 2: March 2008

1BXR

84.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00996
(show subtarget assignments)

1

in_crystallization_trials

No

STM2310

16765637

menF

menaquinone-specific isochorismate synth...

431

Drug Target Function

Phase 2: March 2008

2EUA

78.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00995
(show subtarget assignments)

1

in_pdb
3H02

No

STM2307

16765634

menB

naphthoate synthase

285

Conserved Gene / Pathway

Phase 2: March 2008

3H02

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00527
(show subtarget assignments)

1

purified

No

YPO0129

16120472

bioH

putative biotin biosynthesis protein

258

Drug Target Function

Phase 2: March 2008

1M33

63.6%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00994
(show subtarget assignments)

1

in_pdb
3GC2

No

STM2306

16765633

menC

O-succinylbenzoate synthase

320

Conserved Gene / Pathway

Phase 2: March 2008

3GC2

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00525
(show subtarget assignments)

1

cloned

No

YPMT1.83

16082875

caf1A

putative F1 capsule anchoring protein

833

Virulence Associated Factor

Phase 2: March 2008

3RFZ

35.3%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00993
(show subtarget assignments)

0

work_stopped

No

STM2250

16765578

ccmE

cytochrome c-type biogenesis protein Ccm...

159

Conserved Gene / Pathway

Phase 2: March 2008

1SR3

68.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00992
(show subtarget assignments)

1

soluble

No

STM2227

16765556

yejL

putative cytoplasmic protein

75

Conserved Gene / Pathway

Phase 2: March 2008

2JRX

90.7%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00991
(show subtarget assignments)

1

in_crystallization_trials

No

STM2212

16765541

yeiR

putative cobalamin biosynthetic protein ...

328

Conserved Gene / Pathway

Phase 2: March 2008

1NIJ

18.9%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00524
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0490

16120820

apaH

diadenosine tetraphosphatase

289

Conserved Gene / Pathway

Phase 2: March 2008

2DFJ

73.7%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP00990
(show subtarget assignments)

0

work_stopped

No

STM2193

16765523

folE

GTP cyclohydrolase I

222

Conserved Gene / Pathway

Phase 2: March 2008

1FBX

95.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00989
(show subtarget assignments)

1

purified

No

STM2183

16765513

cdd

cytidine deaminase

294

Conserved Gene / Pathway

Phase 2: March 2008

1AF2

87.4%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP00522
(show subtarget assignments)

1

soluble

No

YPO3423

16123572

ampD

N-acetyl-anhydromuranmyl-L-alanine amida...

183

Conserved Gene / Pathway

Phase 2: March 2008

1J3G

62.3%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00988
(show subtarget assignments)

1

expressed

No

STM2163

16765493

yehX

putative ABC-type proline/glycine betain...

315

Conserved Gene / Pathway

Phase 2: March 2008

1V43

32.4%

Salmonella enterica

Transport and binding proteins

Other

IDP00987
(show subtarget assignments)

1

soluble

No

STM2147

16765476

thiM

hydroxyethylthiazole kinase

265

Conserved Gene / Pathway

Phase 2: March 2008

1C3Q

36.6%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP00523
(show subtarget assignments)

1

in_pdb
3OZH
3RJU

Yes

YPO1224

16121513

ampH

beta-lactamase/D-alanine carboxypeptidas...

388

Conserved Gene / Pathway

Phase 2: March 2008

3OZH

89.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00986
(show subtarget assignments)

1

cloned

No

STM2106

16765436

wcaI

predicted glycosyl transferase

407

Drug Target Function

Phase 2: March 2008

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00521
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3180

16123342

thiL

thiamine monophosphate kinase

329

Conserved Gene / Pathway

Phase 2: March 2008

3MCQ

41.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP00985
(show subtarget assignments)

1

soluble

No

STM2076

16765406

hisA

1-(5-phosphoribosyl)-5-[(5-phosphoribosy...

245

Conserved Gene / Pathway

Phase 2: March 2008

2Y85

35.1%

Salmonella enterica

Amino acid biosynthesis

Histidine family

IDP00984
(show subtarget assignments)

1

in_crystallization_trials

No

STM2073

16765403

hisC

histidinol-phosphate aminotransferase

359

Conserved Gene / Pathway

Phase 2: March 2008

1FG3

88%

Salmonella enterica

Amino acid biosynthesis

Histidine family

IDP00983
(show subtarget assignments)

1

cloned

No

STM2064

16765394

phsB

thiosulfate reductase electron transport...

192

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

37%

Salmonella enterica

Energy metabolism

Electron transport

IDP00520
(show subtarget assignments)

1

in_pdb
3F6M
3FPI

No

YPO3360

16123510

ispF

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

162

Conserved Gene / Pathway

Phase 2: March 2008

3F6M

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00982
(show subtarget assignments)

1

soluble

No

STM2062

16765392

dacD

D-alanyl-D-alanine carboxypeptidase

390

Drug Target Function

Phase 2: March 2008

1NZO

45.1%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00981
(show subtarget assignments)

1

in_crystallization_trials

No

STM2052

16765382

pduQ

propanol dehydrogenase

370

Conserved Gene / Pathway

Phase 2: March 2008

3OWO

35.3%

Salmonella enterica

Energy metabolism

Fermentation

IDP00519
(show subtarget assignments)

1

cloned

No

YPO3446

16123594

argI

ornithine carbamoyltransferase subunit I...

335

Conserved Gene / Pathway

Phase 2: March 2008

1AKM

79.1%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP00518
(show subtarget assignments)

1

cloned

No

YPO1566

16121836

putative hydrolase

280

Virulence Associated Factor

Phase 2: March 2008

3QDF

31.8%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00980
(show subtarget assignments)

1

in_crystallization_trials

No

STM1970

16765308

fliG

flagellar motor switch protein G

331

Conserved Gene / Pathway

Phase 2: March 2008

3HJL

28.7%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP00979
(show subtarget assignments)

1

purified

No

STM1953

16765291

yedO

D-cysteine desulfhydrase

328

Conserved Gene / Pathway

Phase 2: March 2008

1J0A

38.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP00978
(show subtarget assignments)

1

purified

No

STM1951

16765289

yecC

putative amino-acid ABC transporter ATP-...

250

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

54.8%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00517
(show subtarget assignments)

1

soluble

No

YPMT1.71

16082863

hypothetical protein YPMT1.71

328

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Cellular processes

Cell division

IDP00977
(show subtarget assignments)

1

expressed

No

STM1932

16765273

ftnB

ferritin-like protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1EUM

33.5%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00976
(show subtarget assignments)

1

in_crystallization_trials

No

STM1879

16765221

ptrB

protease 2

683

Drug Target Function

Phase 2: March 2008

2XE4

37.6%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00975
(show subtarget assignments)

1

cloned

No

STM1815

16765156

minD

cell division inhibitor MinD

270

Conserved Gene / Pathway

Phase 2: March 2008

3Q9L

93.3%

Salmonella enterica

Cellular processes

Cell division

IDP00516
(show subtarget assignments)

1

purified

No

YPO4022

16124145

putative iron transport protein

317

Conserved Gene / Pathway

Phase 2: March 2008

3GFV

34.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00974
(show subtarget assignments)

1

in_crystallization_trials

No

STM1775

16765116

hemK

N5-glutamine S-adenosyl-L-methionine-dep...

277

Essential Gene

Phase 2: March 2008

1T43

76.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00973
(show subtarget assignments)

1

purified

No

STM1756

16765100

purU

formyltetrahydrofolate deformylase

280

Conserved Gene / Pathway

Phase 2: March 2008

3O1L

42.7%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00514
(show subtarget assignments)

1

selected

No

YPO3721

16123859

hemolysin

1635

Conserved Gene / Pathway

Phase 2: March 2008

3FY3

9%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00972
(show subtarget assignments)

1

expressed

No

STM1743

16765087

oppD

oligopeptide transporter ATP-binding com...

335

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

25.7%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00971
(show subtarget assignments)

1

in_pdb
3IAH

Yes

STM1717

16765061

yciK

short chain dehydrogenase

253

Conserved Gene / Pathway

Phase 2: March 2008

3IAH

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP00515
(show subtarget assignments)

1

cloned

No

YPO3922

16124053

hemophore HasA

205

Virulence Associated Factor

Phase 2: March 2008

1B2V

29.8%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00970
(show subtarget assignments)

1

soluble

No

STM1682

16765025

tpx

thiol peroxidase

168

Conserved Gene / Pathway

Phase 2: March 2008

1QXH

87.5%

Salmonella enterica

Cellular processes

Detoxification

IDP00969
(show subtarget assignments)

1

purified

No

STM1597

161353598

ydcW

putative aldehyde dehydrogenase

474

Conserved Gene / Pathway

Phase 2: March 2008

1WNB

83.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00968
(show subtarget assignments)

1

in_pdb
3M07

No

STM1560

16764904

putative alpha amylase

594

Essential Gene

Phase 2: March 2008

3M07

100%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00967
(show subtarget assignments)

1

in_crystallization_trials

No

STM1559

16764903

putative glycosyl hydrolase

842

Essential Gene

Phase 2: March 2008

3HJE

31.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00513
(show subtarget assignments)

1

cloned

No

YPO3674

16123817

putative insecticidal toxin

1011

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00966
(show subtarget assignments)

1

expressed

No

STM1552

16764897

putative cytoplasmic protein

302

Essential Gene

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00965
(show subtarget assignments)

1

purified

No

STM1463

16764811

add

adenosine deaminase

333

Conserved Gene / Pathway

Phase 2: March 2008

1NDV

33.8%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP00512
(show subtarget assignments)

1

cloned

No

YPO2244

16122472

electron transport complex protein RnfC ...

620

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00511
(show subtarget assignments)

1

in_pdb
3RPE

No

YPO0670

16120995

mdaB

putative modulator of drug activity

194

Conserved Gene / Pathway

Phase 2: March 2008

3RPE

100%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00964
(show subtarget assignments)

0

work_stopped

No

STM1439

16764787

ydhF

putative aldo/keto reductase

298

Conserved Gene / Pathway

Phase 2: March 2008

1OG6

88.9%

Salmonella enterica

Unknown function

General

IDP00963
(show subtarget assignments)

1

in_crystallization_trials

No

STM1436

16764784

nemA

N-ethylmaleimide reductase, FMN-linked

365

Conserved Gene / Pathway

Phase 2: March 2008

3P62

87.4%

Salmonella enterica

Central intermediary metabolism

Other

IDP00510
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3572

16123716

hypothetical protein YPO3572

207

Virulence Associated Factor

Phase 2: March 2008

2QGU

30%

Yersinia pestis

Cell envelope

Other

IDP00962
(show subtarget assignments)

1

cloned

No

STM1427

16764775

cfa

cyclopropane fatty acyl phospholipid syn...

382

Drug Target Function

Phase 2: March 2008

1KP9

26.7%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00509
(show subtarget assignments)

1

in_pdb
3RY3

No

YPO2660

16122866

putative solute-binding protein

525

Conserved Gene / Pathway

Phase 2: March 2008

3RY3

100%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00961
(show subtarget assignments)

1

expressed

No

STM1385

16764735

ttrB

tetrathionate reductase complex subunit ...

250

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

34.4%

Salmonella enterica

Energy metabolism

Electron transport

IDP00960
(show subtarget assignments)

1

in_pdb
3HMQ

No

STM1310

16764661

nadE

NAD synthetase

275

Drug Target Function

Phase 2: March 2008

3HMQ

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00959
(show subtarget assignments)

1

soluble

No

STM1303

16764654

argD

bifunctional succinylornithine transamin...

408

Conserved Gene / Pathway

Phase 2: March 2008

2PB0

60.8%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP00508
(show subtarget assignments)

1

expressed

No

YPO1315

16121597

putative hydrolase

216

Conserved Gene / Pathway

Phase 2: March 2008

3FVV

35.2%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00958
(show subtarget assignments)

1

soluble

No

STM1218

16764573

lolD

lipoprotein transporter ATP-binding subu...

233

Conserved Gene / Pathway

Phase 2: March 2008

2PCJ

43.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00957
(show subtarget assignments)

0

work_stopped

No

STM1202

16764557

ycfH

predicted metallodependent hydrolase

265

Conserved Gene / Pathway

Phase 2: March 2008

1YIX

92.8%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP00506
(show subtarget assignments)

1

expressed

No

YPO2491

16122712

putative hemolysin activator protein

562

Conserved Gene / Pathway

Phase 2: March 2008

2QDZ

21.9%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00956
(show subtarget assignments)

1

in_pdb
3H0P

No

STM1194

16764549

fabD

acyl carrier protein S-malonyltransferas...

309

potential drug target / Essential Gene

Phase 2: March 2008

3H0P

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00955
(show subtarget assignments)

1

cloned

No

STM1192

16764547

plsX

fatty acid/phospholipid synthesis protei...

359

Conserved Gene / Pathway

Phase 2: March 2008

1U7N

36.5%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00507
(show subtarget assignments)

1

purified

No

YPO2511

16122732

hypothetical protein YPO2511

375

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cell envelope

Other

Targets