Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01647 (show subtarget assignments)	1	expressed	No	CBU_0795	29541389	folE	GTP cyclohydrolase I [Coxiella burnetii ...	184	Conserved; Drug target functions	Phase 3: June 2008	1WM9	56%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00804 (show subtarget assignments)	1	expressed	No	SACOL1787	57286221		bifunctional 3-deoxy-7-phosphoheptulonat...	363	Drug Target Function	Phase 2: March 2008	3NVT	66.9%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP90284 (show subtarget assignments)	8	expressed	No	TGME49_070250	211963365		dense granule protein 1 / major antigenp...	190	GRA1 is secreted from dense granule as one of the few soluble proteins that can ...	Community Requests			Toxoplasma gondii

IDP04051 (show subtarget assignments)	1	expressed	No	YPO0511	115346320		hypothetical protein [Yersinia pestis CO...	205	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP05348 (show subtarget assignments)	1	expressed	No	CD2408	126700023		putative multidrug efflux pump, outer me...	439	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP00799 (show subtarget assignments)	1	expressed	No	SACOL1403	57284557	trpE	anthranilate synthase component I	468	Drug Target Function	Phase 2: March 2008	1QDL	33.3%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP00797 (show subtarget assignments)	1	expressed	No	SACOL1250	57285989		chromosome segregation SMC protein, puta...	1188	Conserved Gene / Pathway	Phase 2: March 2008	1W1W	7.5%	Staphylococcus aureus	Cellular processes	Cell division

IDP02673 (show subtarget assignments)	1	expressed	No	STM4466	16767711		carbamate kinase [Salmonella typhimurium...	310	Conserved; Drug target functions	Phase 3: June 2008	1E19	45.5%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP90294 (show subtarget assignments)	8	expressed	No	TGME49_113230	211962198		eukaryotic translation initiation factor...	347	Under stress conditions, the initiation factor 2a (TgIF2a) is phosphorylated to ...	Community Requests	1Q8K	40.3%	Toxoplasma gondii

IDP90312 (show subtarget assignments)	8	expressed	No	CT_712	3329168		hypothetical protein [Chlamydia trachoma...	390	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90330 (show subtarget assignments)	8	expressed	No	CT_602	3329047		hypothetical protein [Chlamydia trachoma...	130	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP00087 (show subtarget assignments)	1	expressed	No	NTL01ST2379	16420989	STM2449	putative acetyltransferase	178	Virulence	Phase 1: October 2007	2PDO	75.3%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00428 (show subtarget assignments)	1	expressed	No	YPO2355	16122579	sapA	peptide transport periplasmic protein pr...	548	Conserved Gene / Pathway	Phase 2: March 2008	1DPP	36.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01625 (show subtarget assignments)	1	expressed	No	FTT1761	56708756		hypothetical protein FTT1761 [Francisell...	239	Drug Target	Phase 3: June 2008			Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP00790 (show subtarget assignments)	1	expressed	No	SACOL1103	57285889	pdhB	pyruvate dehydrogenase complex E1 compon...	325	Drug Target Function	Phase 2: March 2008	3DUF	75.7%	Staphylococcus aureus	Energy metabolism	Pyruvate dehydrogenase

IDP01624 (show subtarget assignments)	1	expressed	No	CBU_1879	29542436		polypeptide deformylase, putative [Coxie...	209	Conserved; Drug target functions	Phase 3: June 2008	1LM6	29.2%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP01619 (show subtarget assignments)	1	expressed	No	CBU_1871	29542425	pabA	para-aminobenzoate synthase glutamine am...	201	Conserved; Drug target functions	Phase 3: June 2008	1QDL	44.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP90223 (show subtarget assignments)	1	expressed	No	SA1226	15926974	Asd	Aspartate semialdehyde dehydrogenase Asd...	329	This enzyme participates in glycine, serine and threonine metabolism and lysine ...	January 2009	2YV3	43.4%	Staphylococcus aureus

IDP04566 (show subtarget assignments)	1	expressed	No	CPF_1876	110800623		putative lipoprotein [Clostridium perfri...	221	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP90242 (show subtarget assignments)	8	expressed	No	SA1814	15927582		succinyl-diaminopimelate desuccinylase [...	407	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3TX8	25.5%	Staphylococcus aureus

IDP90244 (show subtarget assignments)	8	expressed	No	YPO3053	218930098	dapE	succinyl-diaminopimelate desuccinylase [...	375	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3IC1	63.2%	Yersinia pestis

IDP05288 (show subtarget assignments)	1	expressed	No	CD0252	126697823	fliJ	flagellar protein [Clostridium difficile...	148	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP90250 (show subtarget assignments)	8	expressed	No	Z5515	15804553	argE	acetylornithine deacetylase [Escherichia...	383	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3IC1	26.9%	Escherichia coli

IDP00781 (show subtarget assignments)	1	expressed	No	SACOL0845	57284307	est	carboxylesterase	246	Conserved Gene / Pathway	Phase 2: March 2008	1R1D	57.7%	Staphylococcus aureus	Cellular processes	Detoxification

IDP00780 (show subtarget assignments)	1	expressed	No	SACOL0694	57285664		tagH protein, teichoic acid ABC transpor...	264	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	23.9%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01602 (show subtarget assignments)	1	expressed	No	YPO2288	16122512	amn	AMP nucleosidase [Yersinia pestis CO92]	546	CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...	Phase 3: June 2008	1T8R	63.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP01601 (show subtarget assignments)	1	expressed	No	CBU_0746	29541346		ABC transporter, ATP-binding protein [Co...	249	Conserved; Drug target functions	Phase 3: June 2008	3FVQ	34.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP90251 (show subtarget assignments)	8	expressed	No	SF4034	56480493	argE	acetylornithine deacetylase [Shigella fl...	383	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2F7V	25.1%	Shigella flexneri

IDP05218 (show subtarget assignments)	1	expressed	No	CD3433	126701056	cbiB	cobalamin biosynthesis protein [Clostrid...	323	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP01520 (show subtarget assignments)	1	expressed	No	VCA0782	15601537		ABC transporter, ATP-binding protein	225	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	46.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP05284 (show subtarget assignments)	1	expressed	No	CD0369	126697939		hypothetical protein CD0369 [Clostridium...	74	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP90214 (show subtarget assignments)	8	expressed	No	MYXV_gp017	9633649	m013L	m013L, M013L	126	interferon inducible protein	Community Requests			Myxoma virus	unknown	0

IDP01517 (show subtarget assignments)	1	expressed	No	VC1254	15641267		iron-sulfur cluster-binding protein, put...	92	Conserved Gene / Pathway	Phase 2: March 2008	1AWD	26.1%	Vibrio cholerae	Energy metabolism	Electron transport

IDP90215 (show subtarget assignments)	8	expressed	No	MYXV_gp009	9633800	m006L	m006L, m6	509	contains kelch motifs, similar to MYX-L-m006R	Community Requests	1X2J	13.9%	Myxoma virus	unknown	0

IDP90209 (show subtarget assignments)	8	expressed	No	MYXV_gp144	9633776	m140R	m140R	553	kelch motif, similar to VACV-Cop:A55R	Community Requests	1U6D	14.3%	Myxoma virus	unknown, conserved protein	0

IDP90210 (show subtarget assignments)	8	expressed	No	MYXV_gp140	9633772	m136R	m136R	179	unknown, similar to VACV-Cop:A52R	Community Requests	2VVW	20.1%	Myxoma virus	unknown, conserved protein	0

IDP01511 (show subtarget assignments)	1	expressed	No	VC0794	15640812		hypothetical protein VC0794	139	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP05277 (show subtarget assignments)	1	expressed	No	YPO2630	16122843	glnS	glutaminyl-tRNA synthetase [Yersinia pes...	598	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1O0B	80.3%	Yersinia pestis	Protein synthesis: tRNA aminoacylation

IDP01509 (show subtarget assignments)	1	expressed	No	VC0549	15640571		oxaloacetate decarboxylase subunit gamma...	117	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01508 (show subtarget assignments)	1	expressed	No	VCA0127	15600898		ribose ABC transporter protein	156	Conserved Gene / Pathway	Phase 2: March 2008	3DSA	48.1%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP90216 (show subtarget assignments)	8	expressed	No	MYXV_gp008	9633799	m005L	m005L, m5, M-T5	483	ankyrin motif, similar to VACV-Cop:B4R. Possible apoptosis regulator.	Community Requests	1N0R	8.5%	Myxoma virus	host range factor, host defense modulator	0

IDP00763 (show subtarget assignments)	1	expressed	No	SACOL0262	57286722		Ccholoylglycine hydrolase family protein...	330	Conserved Gene / Pathway	Phase 2: March 2008	2OQC	32.4%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00764 (show subtarget assignments)	1	expressed	No	SACOL0447	57286820		phosphoglycerate mutase family protein	193	Drug Target Function	Phase 2: March 2008	1C7Z	31.1%	Staphylococcus aureus	Unknown function	General

IDP01505 (show subtarget assignments)	1	expressed	No	VCA1037	15601788		amino acid ABC transporter, ATP-binding ...	239	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	52.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01504 (show subtarget assignments)	1	expressed	No	VCA1028	15601781	lamB	maltoporin	416	Conserved Gene / Pathway	Phase 2: March 2008	1AF6	32.7%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00416 (show subtarget assignments)	1	expressed	No	YPO1212	16121503		2Fe-2S ferredoxin YfaE	85	Conserved Gene / Pathway	Phase 2: March 2008	3AV8	33.3%	Yersinia pestis	Energy metabolism	Electron transport

IDP01502 (show subtarget assignments)	1	expressed	No	VCA0977	15601730		ABC transporter, ATP-binding protein	539	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	23.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01501 (show subtarget assignments)	1	expressed	No	VCA0946	15601699		maltose/maltodextrin transporter ATP-bin...	373	Conserved Gene / Pathway	Phase 2: March 2008	1Q12	67.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP90205 (show subtarget assignments)	8	expressed	No	AAM13465.1	20153004	CPXV018 CDS	CPXV018 protein, VO18	171	similar to MPV-Z-N3R	Community Requests			Cowpox virus	host defense modulator	0

IDP01498 (show subtarget assignments)	1	expressed	No	VCA0862	15601617		long-chain fatty acid transport protein ...	412	Conserved Gene / Pathway	Phase 2: March 2008	1T16	39.2%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00415 (show subtarget assignments)	1	expressed	No	YPO3767	16123903	fadA	3-ketoacyl-CoA thiolase	387	Virulence Associated Factor	Phase 2: March 2008	3GOA	79.8%	Yersinia pestis	Cellular processes	Detoxification

IDP04038 (show subtarget assignments)	1	expressed	No	YPCD1.65	5832485	YPCD1.65	putative transposase [Yersinia pestis CO...	102	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP00414 (show subtarget assignments)	1	expressed	No	YPO1322	16121604	deoR	DNA-binding transcriptional repressor	254	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Cellular processes	Toxin production and resistance

IDP04089 (show subtarget assignments)	1	expressed	No	STM1952_1_222	16765290	yecS	putative ABC-type amino acid transporter...	222	Salmonella essential protein	Phase 4: April 2009	2R6G	24.3%	Salmonella enterica

IDP00084 (show subtarget assignments)	1	expressed	No	NT01ST1435	16419673	yceI	putative secreted protein	191	Essential	Phase 1: October 2007	1Y0G	91.1%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90208 (show subtarget assignments)	8	expressed	No	MYXV_gp143	9633775	m139R	m139R	188	Intracellular TLR and IL-1 signaling inhibitor, similar to VACV-Cop:A52R	Community Requests	2VVW	32.4%	Myxoma virus	host defense modulator	0

IDP90219 (show subtarget assignments)	8	expressed	No	MYXV_gp011	9633802	m008L	m008L, m8	515	contains kelch motifs, similar to MYX-L-m006R	Community Requests	2XN4	11.5%	Myxoma virus	unknown	0

IDP00169 (show subtarget assignments)	1	expressed	No	VCA0218	15600987	No Data	thermolabile hemolysin	418	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01490 (show subtarget assignments)	1	expressed	No	VCA0602	15601360		ABC transporter, ATP-binding protein	403	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	34%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP04025 (show subtarget assignments)	1	expressed	No	YPCD1.36c	16082724	yscX	hypothetical protein YPCD1.36c [Yersinia...	122	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04026 (show subtarget assignments)	1	expressed	No	FTT0456c	56707598		hypothetical protein FTT_0456c [Francise...	97	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1YHD	39.2%	Francisella tularensis

IDP00412 (show subtarget assignments)	1	expressed	No	YPO0169	16120512	pabA	para-aminobenzoate synthase component II...	191	Drug Target Function	Phase 2: March 2008	1QDL	46.2%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04543 (show subtarget assignments)	1	expressed	No	VC2453	9657030		sensor histidine kinase/response regulat...	927	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	8.1%	Vibrio cholerae	Regulatory functions	Other

IDP90194 (show subtarget assignments)	8	expressed	No	AAM13639.1	20153178	CPXV200 CDS	CPXV200 protein	179	ankyrin-like protein	Community Requests			Cowpox virus	conserved hypothetical proteins	0

IDP04542 (show subtarget assignments)	1	expressed	No	YPO2000	218929110		putative two-component system sensor pro...	463	putative drug target function;	Phase 4: April 2009	3JZ3	13.2%	Yersinia pestis	Regulatory functions	Other

IDP90191 (show subtarget assignments)	8	expressed	No	AAM13632.1	20153171	CPXV193 CDS	CPXV193 protein	563	kelch-like protein	Community Requests	3II7	13%	Cowpox virus	conserved hypothetical proteins	0

IDP01481 (show subtarget assignments)	1	expressed	No	VCA0130	15600901		D-ribose transporter subunit RbsB	294	Conserved Gene / Pathway	Phase 2: March 2008	1DBP	65.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01479 (show subtarget assignments)	1	expressed	No	VCA0064	15600835		TonB system receptor, putative	713	Conserved Gene / Pathway	Phase 2: March 2008	1NQF	22.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP05264 (show subtarget assignments)	1	expressed	No	CD3257	126700876		putative polysaccharide deacetylase [Clo...	275	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1W17	25.5%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01474 (show subtarget assignments)	1	expressed	No	VC2657	15642652		fumarate reductase iron-sulfur subunit	252	Conserved Gene / Pathway	Phase 2: March 2008	1KF6	69%	Vibrio cholerae	Energy metabolism	Anaerobic

IDP04528 (show subtarget assignments)	1	expressed	No	STM2257_1_289	16765585	napH	quinol dehydrogenase membrane component ...	289	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04021 (show subtarget assignments)	1	expressed	No	BAS3695	49186694		30S ribosomal protein S16 [Bacillus anth...	90	Proposed to be essential proteins	Phase 4: April 2009	1EMW	42.2%	Bacillus anthracis

IDP02656 (show subtarget assignments)	1	expressed	No	FTT0558	56707688		short chain dehydrogenase [Francisella t...	203	Drug Target	Phase 3: June 2008	3D7L	41.9%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP00166 (show subtarget assignments)	1	expressed	No	VC1450	15641461	rtxC	RTX toxin activating protein	153	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP04526 (show subtarget assignments)	1	expressed	No	STM1637_1_516	16764981		putative inner membrane protein [Salmone...	516	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP90184 (show subtarget assignments)	8	expressed	No	AAM13486.1	20153025	CPXV039 CDS	CPXV039 protein	473	ankyrin repeat protein	Community Requests	1N11	14.4%	Cowpox virus	conserved hypothetical proteins	0

IDP90198 (show subtarget assignments)	8	expressed	No	AAM13648.1	20153187	CPXV209	CPXV209 protein	326	soluble secreted IL-1 binding protein	Community Requests	3O4O	28.5%	Cowpox virus	host defense modulator	0

IDP00737 (show subtarget assignments)	1	expressed	No	SACOL0993	57284367	oppD	oligopeptide ABC transporter, ATP-bindin...	360	Drug Target Function	Phase 2: March 2008	1B0U	25%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP04515 (show subtarget assignments)	1	expressed	No	CPF_2673	110799735		putative sensor histidine kinase [Clostr...	583	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	13.9%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP90175 (show subtarget assignments)	8	expressed	No	AAM13468.1	20153007	VGF	CPXV021 protein or CPXV VGF protein	139	similar to viral growth factor C11R vaccinia virus	Community Requests	1K36	15.8%	Cowpox virus	host range protein	0

IDP90176 (show subtarget assignments)	8	expressed	No	AAM13470.1	20153009	CPXV023 CDS	CPXV023 protein	242	zinc-finger-like protein	Community Requests	2ECW	8.3%	Cowpox virus	host defense modulator	0

IDP00080 (show subtarget assignments)	1	expressed	No	NT01ST5073	16422645	yneC	putative inner membrane protein	109	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3QMQ	70.6%	Salmonella enterica	Cell envelope	Other

IDP90177 (show subtarget assignments)	8	expressed	No	AAM13471.1	20153010	CPXV024 CDS	CPXV024 protein	126	Orthopoxvirus interleukin 18 binding protein; plays a key role in the activation...	Community Requests	3F62	80.2%	Cowpox virus	host defense modulator	0

IDP01442 (show subtarget assignments)	1	expressed	No	VC2048	15642050		vacJ lipoprotein	254	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Other

IDP01438 (show subtarget assignments)	1	expressed	No	VC1993	15641995		2,4-dienoyl-CoA reductase	666	Drug Target Function	Phase 2: March 2008	1PS9	56.6%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Degradation

IDP90169 (show subtarget assignments)	8	expressed	No	AAM13454.1	20152993	CPXV008 CDS	CPXV008 protein	672	Potential drug target. Shikimate pathway enzyme	Community Requests			Cowpox virus	conserved hypothetical proteins	0

IDP04289 (show subtarget assignments)	1	expressed	No	YPCD1.35c	16082723	yscY	hypothetical protein YPCD1.35c [Yersinia...	114	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04279 (show subtarget assignments)	1	expressed	No	YPO0260	218927465		putative AraC-family regulatory protein ...	206	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	3OIO	16.5%	Yersinia pestis	Regulatory functions	Other

IDP05221 (show subtarget assignments)	1	expressed	No	BA_4349	30258849		hypothetical protein BA_4349 [Bacillus a...	62	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05240 (show subtarget assignments)	1	expressed	No	CD0233	126697804		hypothetical protein CD0233 [Clostridium...	130	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2AJ7	33.1%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP90358 (show subtarget assignments)	8	expressed	No	CT273	15604994		hypothetical protein CT273 [Chlamydia tr...	188	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP00357 (show subtarget assignments)	1	expressed	No	lmo0885	16802926	acpS	hypothetical protein lmo0885	118	Drug Target Function	Phase 2: March 2008	1F7L	50%	Listeria monocytogenes	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01426 (show subtarget assignments)	1	expressed	No	VC1680	15641684		peptide ABC transporter, periplasmic pep...	540	Conserved Gene / Pathway	Phase 2: March 2008	1DPP	35%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP90136 (show subtarget assignments)	8	expressed	No	MPXV_ZAI1979_005_177	68449248		ser/thr kinase [Monkeypox virus]	299	essential for viral DNA replication, similar to VACV-COP-B1R, MPXV-ZAI96-B3R	Community Requests	2V62	40.4%	Monkeypox virus

IDP01425 (show subtarget assignments)	1	expressed	No	VC1630	15641635		ABC transporter, ATP-binding protein	227	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	37%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP00721 (show subtarget assignments)	1	expressed	No	SACOL1613	57286135		ABC transporter, ATP-binding protein	261	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	31.8%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01422 (show subtarget assignments)	1	expressed	No	VC1549	15641557		glycerol-3-phosphate ABC transporter, pe...	434	Conserved Gene / Pathway	Phase 2: March 2008	2HEU	20%	Vibrio cholerae	Transport and binding proteins	Other

IDP04488 (show subtarget assignments)	1	expressed	No	YPO3685	115349305	yhcQ	putative HlyD family secretion protein [...	311	conserved gene; putative drug target function;	Phase 4: April 2009	2F1M	17%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04494 (show subtarget assignments)	1	expressed	No	VC0591	15640612	panC	pantoate--beta-alanine ligase [Vibrio ch...	293	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3Q10	57%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02835 (show subtarget assignments)	1	expressed	No	FTT0631	56707756	hflX	protease, GTP-binding subunit [Francisel...	435	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2QTF	22.8%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01647
(show subtarget assignments)

1

expressed

No

CBU_0795

29541389

folE

GTP cyclohydrolase I [Coxiella burnetii ...

184

Conserved; Drug target functions

Phase 3: June 2008

1WM9

56%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00804
(show subtarget assignments)

1

expressed

No

SACOL1787

57286221

bifunctional 3-deoxy-7-phosphoheptulonat...

363

Drug Target Function

Phase 2: March 2008

3NVT

66.9%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family

IDP90284
(show subtarget assignments)

8

expressed

No

TGME49_070250

211963365

dense granule protein 1 / major antigenp...

190

GRA1 is secreted from dense granule as one of the few soluble proteins that can ...

Community Requests

Toxoplasma gondii

IDP04051
(show subtarget assignments)

1

expressed

No

YPO0511

115346320

hypothetical protein [Yersinia pestis CO...

205

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP05348
(show subtarget assignments)

1

expressed

No

CD2408

126700023

putative multidrug efflux pump, outer me...

439

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP00799
(show subtarget assignments)

1

expressed

No

SACOL1403

57284557

trpE

anthranilate synthase component I

468

Drug Target Function

Phase 2: March 2008

1QDL

33.3%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family

IDP00797
(show subtarget assignments)

1

expressed

No

SACOL1250

57285989

chromosome segregation SMC protein, puta...

1188

Conserved Gene / Pathway

Phase 2: March 2008

1W1W

7.5%

Staphylococcus aureus

Cellular processes

Cell division

IDP02673
(show subtarget assignments)

1

expressed

No

STM4466

16767711

carbamate kinase [Salmonella typhimurium...

310

Conserved; Drug target functions

Phase 3: June 2008

1E19

45.5%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP90294
(show subtarget assignments)

8

expressed

No

TGME49_113230

211962198

eukaryotic translation initiation factor...

347

Under stress conditions, the initiation factor 2a (TgIF2a) is phosphorylated to ...

Community Requests

1Q8K

40.3%

Toxoplasma gondii

IDP90312
(show subtarget assignments)

8

expressed

No

CT_712

3329168

hypothetical protein [Chlamydia trachoma...

390

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90330
(show subtarget assignments)

8

expressed

No

CT_602

3329047

hypothetical protein [Chlamydia trachoma...

130

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP00087
(show subtarget assignments)

1

expressed

No

NTL01ST2379

16420989

STM2449

putative acetyltransferase

178

Virulence

Phase 1: October 2007

2PDO

75.3%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00428
(show subtarget assignments)

1

expressed

No

YPO2355

16122579

sapA

peptide transport periplasmic protein pr...

548

Conserved Gene / Pathway

Phase 2: March 2008

1DPP

36.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01625
(show subtarget assignments)

1

expressed

No

FTT1761

56708756

hypothetical protein FTT1761 [Francisell...

239

Drug Target

Phase 3: June 2008

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP00790
(show subtarget assignments)

1

expressed

No

SACOL1103

57285889

pdhB

pyruvate dehydrogenase complex E1 compon...

325

Drug Target Function

Phase 2: March 2008

3DUF

75.7%

Staphylococcus aureus

Energy metabolism

Pyruvate dehydrogenase

IDP01624
(show subtarget assignments)

1

expressed

No

CBU_1879

29542436

polypeptide deformylase, putative [Coxie...

209

Conserved; Drug target functions

Phase 3: June 2008

1LM6

29.2%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP01619
(show subtarget assignments)

1

expressed

No

CBU_1871

29542425

pabA

para-aminobenzoate synthase glutamine am...

201

Conserved; Drug target functions

Phase 3: June 2008

1QDL

44.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP90223
(show subtarget assignments)

1

expressed

No

SA1226

15926974

Asd

Aspartate semialdehyde dehydrogenase Asd...

329

This enzyme participates in glycine, serine and threonine metabolism and lysine ...

January 2009

2YV3

43.4%

Staphylococcus aureus

IDP04566
(show subtarget assignments)

1

expressed

No

CPF_1876

110800623

putative lipoprotein [Clostridium perfri...

221

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP90242
(show subtarget assignments)

8

expressed

No

SA1814

15927582

succinyl-diaminopimelate desuccinylase [...

407

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3TX8

25.5%

Staphylococcus aureus

IDP90244
(show subtarget assignments)

8

expressed

No

YPO3053

218930098

dapE

succinyl-diaminopimelate desuccinylase [...

375

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3IC1

63.2%

Yersinia pestis

IDP05288
(show subtarget assignments)

1

expressed

No

CD0252

126697823

fliJ

flagellar protein [Clostridium difficile...

148

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP90250
(show subtarget assignments)

8

expressed

No

Z5515

15804553

argE

acetylornithine deacetylase [Escherichia...

383

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3IC1

26.9%

Escherichia coli

IDP00781
(show subtarget assignments)

1

expressed

No

SACOL0845

57284307

est

carboxylesterase

246

Conserved Gene / Pathway

Phase 2: March 2008

1R1D

57.7%

Staphylococcus aureus

Cellular processes

Detoxification

IDP00780
(show subtarget assignments)

1

expressed

No

SACOL0694

57285664

tagH protein, teichoic acid ABC transpor...

264

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

23.9%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01602
(show subtarget assignments)

1

expressed

No

YPO2288

16122512

amn

AMP nucleosidase [Yersinia pestis CO92]

546

CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...

Phase 3: June 2008

1T8R

63.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP01601
(show subtarget assignments)

1

expressed

No

CBU_0746

29541346

ABC transporter, ATP-binding protein [Co...

249

Conserved; Drug target functions

Phase 3: June 2008

3FVQ

34.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP90251
(show subtarget assignments)

8

expressed

No

SF4034

56480493

argE

acetylornithine deacetylase [Shigella fl...

383

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2F7V

25.1%

Shigella flexneri

IDP05218
(show subtarget assignments)

1

expressed

No

CD3433

126701056

cbiB

cobalamin biosynthesis protein [Clostrid...

323

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP01520
(show subtarget assignments)

1

expressed

No

VCA0782

15601537

ABC transporter, ATP-binding protein

225

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

46.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP05284
(show subtarget assignments)

1

expressed

No

CD0369

126697939

hypothetical protein CD0369 [Clostridium...

74

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP90214
(show subtarget assignments)

8

expressed

No

MYXV_gp017

9633649

m013L

m013L, M013L

126

interferon inducible protein

Community Requests

Myxoma virus

unknown

0

IDP01517
(show subtarget assignments)

1

expressed

No

VC1254

15641267

iron-sulfur cluster-binding protein, put...

92

Conserved Gene / Pathway

Phase 2: March 2008

1AWD

26.1%

Vibrio cholerae

Energy metabolism

Electron transport

IDP90215
(show subtarget assignments)

8

expressed

No

MYXV_gp009

9633800

m006L

m006L, m6

509

contains kelch motifs, similar to MYX-L-m006R

Community Requests

1X2J

13.9%

Myxoma virus

unknown

0

IDP90209
(show subtarget assignments)

8

expressed

No

MYXV_gp144

9633776

m140R

553

kelch motif, similar to VACV-Cop:A55R

Community Requests

1U6D

14.3%

Myxoma virus

unknown, conserved protein

0

IDP90210
(show subtarget assignments)

8

expressed

No

MYXV_gp140

9633772

m136R

179

unknown, similar to VACV-Cop:A52R

Community Requests

2VVW

20.1%

Myxoma virus

unknown, conserved protein

0

IDP01511
(show subtarget assignments)

1

expressed

No

VC0794

15640812

hypothetical protein VC0794

139

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP05277
(show subtarget assignments)

1

expressed

No

YPO2630

16122843

glnS

glutaminyl-tRNA synthetase [Yersinia pes...

598

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1O0B

80.3%

Yersinia pestis

Protein synthesis: tRNA aminoacylation

IDP01509
(show subtarget assignments)

1

expressed

No

VC0549

15640571

oxaloacetate decarboxylase subunit gamma...

117

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01508
(show subtarget assignments)

1

expressed

No

VCA0127

15600898

ribose ABC transporter protein

156

Conserved Gene / Pathway

Phase 2: March 2008

3DSA

48.1%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP90216
(show subtarget assignments)

8

expressed

No

MYXV_gp008

9633799

m005L

m005L, m5, M-T5

483

ankyrin motif, similar to VACV-Cop:B4R. Possible apoptosis regulator.

Community Requests

1N0R

8.5%

Myxoma virus

host range factor, host defense modulator

0

IDP00763
(show subtarget assignments)

1

expressed

No

SACOL0262

57286722

Ccholoylglycine hydrolase family protein...

330

Conserved Gene / Pathway

Phase 2: March 2008

2OQC

32.4%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00764
(show subtarget assignments)

1

expressed

No

SACOL0447

57286820

phosphoglycerate mutase family protein

193

Drug Target Function

Phase 2: March 2008

1C7Z

31.1%

Staphylococcus aureus

Unknown function

General

IDP01505
(show subtarget assignments)

1

expressed

No

VCA1037

15601788

amino acid ABC transporter, ATP-binding ...

239

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

52.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01504
(show subtarget assignments)

1

expressed

No

VCA1028

15601781

lamB

maltoporin

416

Conserved Gene / Pathway

Phase 2: March 2008

1AF6

32.7%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00416
(show subtarget assignments)

1

expressed

No

YPO1212

16121503

2Fe-2S ferredoxin YfaE

85

Conserved Gene / Pathway

Phase 2: March 2008

3AV8

33.3%

Yersinia pestis

Energy metabolism

Electron transport

IDP01502
(show subtarget assignments)

1

expressed

No

VCA0977

15601730

ABC transporter, ATP-binding protein

539

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

23.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01501
(show subtarget assignments)

1

expressed

No

VCA0946

15601699

maltose/maltodextrin transporter ATP-bin...

373

Conserved Gene / Pathway

Phase 2: March 2008

1Q12

67.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP90205
(show subtarget assignments)

8

expressed

No

AAM13465.1

20153004

CPXV018 CDS

CPXV018 protein, VO18

171

similar to MPV-Z-N3R

Community Requests

Cowpox virus

host defense modulator

0

IDP01498
(show subtarget assignments)

1

expressed

No

VCA0862

15601617

long-chain fatty acid transport protein ...

412

Conserved Gene / Pathway

Phase 2: March 2008

1T16

39.2%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00415
(show subtarget assignments)

1

expressed

No

YPO3767

16123903

fadA

3-ketoacyl-CoA thiolase

387

Virulence Associated Factor

Phase 2: March 2008

3GOA

79.8%

Yersinia pestis

Cellular processes

Detoxification

IDP04038
(show subtarget assignments)

1

expressed

No

YPCD1.65

5832485

YPCD1.65

putative transposase [Yersinia pestis CO...

102

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP00414
(show subtarget assignments)

1

expressed

No

YPO1322

16121604

deoR

DNA-binding transcriptional repressor

254

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP04089
(show subtarget assignments)

1

expressed

No

STM1952_1_222

16765290

yecS

putative ABC-type amino acid transporter...

222

Salmonella essential protein

Phase 4: April 2009

2R6G

24.3%

Salmonella enterica

IDP00084
(show subtarget assignments)

1

expressed

No

NT01ST1435

16419673

yceI

putative secreted protein

191

Essential

Phase 1: October 2007

1Y0G

91.1%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90208
(show subtarget assignments)

8

expressed

No

MYXV_gp143

9633775

m139R

188

Intracellular TLR and IL-1 signaling inhibitor, similar to VACV-Cop:A52R

Community Requests

2VVW

32.4%

Myxoma virus

host defense modulator

0

IDP90219
(show subtarget assignments)

8

expressed

No

MYXV_gp011

9633802

m008L

m008L, m8

515

contains kelch motifs, similar to MYX-L-m006R

Community Requests

2XN4

11.5%

Myxoma virus

unknown

0

IDP00169
(show subtarget assignments)

1

expressed

No

VCA0218

15600987

No Data

thermolabile hemolysin

418

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01490
(show subtarget assignments)

1

expressed

No

VCA0602

15601360

ABC transporter, ATP-binding protein

403

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

34%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP04025
(show subtarget assignments)

1

expressed

No

YPCD1.36c

16082724

yscX

hypothetical protein YPCD1.36c [Yersinia...

122

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04026
(show subtarget assignments)

1

expressed

No

FTT0456c

56707598

hypothetical protein FTT_0456c [Francise...

97

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1YHD

39.2%

Francisella tularensis

IDP00412
(show subtarget assignments)

1

expressed

No

YPO0169

16120512

pabA

para-aminobenzoate synthase component II...

191

Drug Target Function

Phase 2: March 2008

1QDL

46.2%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04543
(show subtarget assignments)

1

expressed

No

VC2453

9657030

sensor histidine kinase/response regulat...

927

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

8.1%

Vibrio cholerae

Regulatory functions

Other

IDP90194
(show subtarget assignments)

8

expressed

No

AAM13639.1

20153178

CPXV200 CDS

CPXV200 protein

179

ankyrin-like protein

Community Requests

Cowpox virus

conserved hypothetical proteins

0

IDP04542
(show subtarget assignments)

1

expressed

No

YPO2000

218929110

putative two-component system sensor pro...

463

putative drug target function;

Phase 4: April 2009

3JZ3

13.2%

Yersinia pestis

Regulatory functions

Other

IDP90191
(show subtarget assignments)

8

expressed

No

AAM13632.1

20153171

CPXV193 CDS

CPXV193 protein

563

kelch-like protein

Community Requests

3II7

13%

Cowpox virus

conserved hypothetical proteins

0

IDP01481
(show subtarget assignments)

1

expressed

No

VCA0130

15600901

D-ribose transporter subunit RbsB

294

Conserved Gene / Pathway

Phase 2: March 2008

1DBP

65.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01479
(show subtarget assignments)

1

expressed

No

VCA0064

15600835

TonB system receptor, putative

713

Conserved Gene / Pathway

Phase 2: March 2008

1NQF

22.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP05264
(show subtarget assignments)

1

expressed

No

CD3257

126700876

putative polysaccharide deacetylase [Clo...

275

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1W17

25.5%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01474
(show subtarget assignments)

1

expressed

No

VC2657

15642652

fumarate reductase iron-sulfur subunit

252

Conserved Gene / Pathway

Phase 2: March 2008

1KF6

69%

Vibrio cholerae

Energy metabolism

Anaerobic

IDP04528
(show subtarget assignments)

1

expressed

No

STM2257_1_289

16765585

napH

quinol dehydrogenase membrane component ...

289

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04021
(show subtarget assignments)

1

expressed

No

BAS3695

49186694

30S ribosomal protein S16 [Bacillus anth...

90

Proposed to be essential proteins

Phase 4: April 2009

1EMW

42.2%

Bacillus anthracis

IDP02656
(show subtarget assignments)

1

expressed

No

FTT0558

56707688

short chain dehydrogenase [Francisella t...

203

Drug Target

Phase 3: June 2008

3D7L

41.9%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP00166
(show subtarget assignments)

1

expressed

No

VC1450

15641461

rtxC

RTX toxin activating protein

153

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP04526
(show subtarget assignments)

1

expressed

No

STM1637_1_516

16764981

putative inner membrane protein [Salmone...

516

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP90184
(show subtarget assignments)

8

expressed

No

AAM13486.1

20153025

CPXV039 CDS

CPXV039 protein

473

ankyrin repeat protein

Community Requests

1N11

14.4%

Cowpox virus

conserved hypothetical proteins

0

IDP90198
(show subtarget assignments)

8

expressed

No

AAM13648.1

20153187

CPXV209

CPXV209 protein

326

soluble secreted IL-1 binding protein

Community Requests

3O4O

28.5%

Cowpox virus

host defense modulator

0

IDP00737
(show subtarget assignments)

1

expressed

No

SACOL0993

57284367

oppD

oligopeptide ABC transporter, ATP-bindin...

360

Drug Target Function

Phase 2: March 2008

1B0U

25%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP04515
(show subtarget assignments)

1

expressed

No

CPF_2673

110799735

putative sensor histidine kinase [Clostr...

583

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

13.9%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP90175
(show subtarget assignments)

8

expressed

No

AAM13468.1

20153007

VGF

CPXV021 protein or CPXV VGF protein

139

Community Requests

1K36

15.8%

Cowpox virus

host range protein

0

IDP90176
(show subtarget assignments)

8

expressed

No

AAM13470.1

20153009

CPXV023 CDS

CPXV023 protein

242

zinc-finger-like protein

Community Requests

2ECW

8.3%

Cowpox virus

host defense modulator

0

IDP00080
(show subtarget assignments)

1

expressed

No

NT01ST5073

16422645

yneC

putative inner membrane protein

109

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3QMQ

70.6%

Salmonella enterica

Cell envelope

Other

IDP90177
(show subtarget assignments)

8

expressed

No

AAM13471.1

20153010

CPXV024 CDS

CPXV024 protein

126

Orthopoxvirus interleukin 18 binding protein; plays a key role in the activation...

Community Requests

3F62

80.2%

Cowpox virus

host defense modulator

0

IDP01442
(show subtarget assignments)

1

expressed

No

VC2048

15642050

vacJ lipoprotein

254

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Other

IDP01438
(show subtarget assignments)

1

expressed

No

VC1993

15641995

2,4-dienoyl-CoA reductase

666

Drug Target Function

Phase 2: March 2008

1PS9

56.6%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Degradation

IDP90169
(show subtarget assignments)

8

expressed

No

AAM13454.1

20152993

CPXV008 CDS

CPXV008 protein

672

Potential drug target. Shikimate pathway enzyme

Community Requests

Cowpox virus

conserved hypothetical proteins

0

IDP04289
(show subtarget assignments)

1

expressed

No

YPCD1.35c

16082723

yscY

hypothetical protein YPCD1.35c [Yersinia...

114

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04279
(show subtarget assignments)

1

expressed

No

YPO0260

218927465

putative AraC-family regulatory protein ...

206

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

3OIO

16.5%

Yersinia pestis

Regulatory functions

Other

IDP05221
(show subtarget assignments)

1

expressed

No

BA_4349

30258849

hypothetical protein BA_4349 [Bacillus a...

62

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05240
(show subtarget assignments)

1

expressed

No

CD0233

126697804

hypothetical protein CD0233 [Clostridium...

130

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2AJ7

33.1%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP90358
(show subtarget assignments)

8

expressed

No

CT273

15604994

hypothetical protein CT273 [Chlamydia tr...

188

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP00357
(show subtarget assignments)

1

expressed

No

lmo0885

16802926

acpS

hypothetical protein lmo0885

118

Drug Target Function

Phase 2: March 2008

1F7L

50%

Listeria monocytogenes

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01426
(show subtarget assignments)

1

expressed

No

VC1680

15641684

peptide ABC transporter, periplasmic pep...

540

Conserved Gene / Pathway

Phase 2: March 2008

1DPP

35%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP90136
(show subtarget assignments)

8

expressed

No

MPXV_ZAI1979_005_177

68449248

ser/thr kinase [Monkeypox virus]

299

essential for viral DNA replication, similar to VACV-COP-B1R, MPXV-ZAI96-B3R

Community Requests

2V62

40.4%

Monkeypox virus

IDP01425
(show subtarget assignments)

1

expressed

No

VC1630

15641635

ABC transporter, ATP-binding protein

227

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

37%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP00721
(show subtarget assignments)

1

expressed

No

SACOL1613

57286135

ABC transporter, ATP-binding protein

261

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

31.8%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01422
(show subtarget assignments)

1

expressed

No

VC1549

15641557

glycerol-3-phosphate ABC transporter, pe...

434

Conserved Gene / Pathway

Phase 2: March 2008

2HEU

20%

Vibrio cholerae

Transport and binding proteins

Other

IDP04488
(show subtarget assignments)

1

expressed

No

YPO3685

115349305

yhcQ

putative HlyD family secretion protein [...

311

conserved gene; putative drug target function;

Phase 4: April 2009

2F1M

17%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04494
(show subtarget assignments)

1

expressed

No

VC0591

15640612

panC

pantoate--beta-alanine ligase [Vibrio ch...

293

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3Q10

57%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02835
(show subtarget assignments)

1

expressed

No

FTT0631

56707756

hflX

protease, GTP-binding subunit [Francisel...

435

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2QTF

22.8%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides