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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 25 of 60, showing 100 records out of 5973 total, starting on record 2401
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP90366
(
show subtarget assignments
)
8
expressed
No
CT_142
3328542
hypothetical protein [Chlamydia trachoma...
285
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90197
(
show subtarget assignments
)
8
soluble
No
AAM13645.1
20153184
CPXV206 CDS
CPXV206 protein
285
serine-threonine kinase
Community Requests
2KTY
32.1%
Cowpox virus
Unknown function
0
IDP01365
(
show subtarget assignments
)
1
purified
No
VC0201
15640231
iron(III) ABC transporter, ATP-binding p...
285
Conserved Gene / Pathway
Phase 2: March 2008
1JJ7
28.1%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP04517
(
show subtarget assignments
)
1
cloned
No
CPF_2840
110799025
ksgA
dimethyladenosine transferase [Clostridi...
285
conserved gene; putative drug target function;
Phase 4: April 2009
3FUT
35.1%
Clostridium perfringens
Cellular processes
Toxin production and resistance
IDP02319
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA1169
47526434
prsA
peptidylprolyl isomerase [Bacillus anthr...
285
Drug target motif; Drug target functions
Phase 3: June 2008
3RFW
29.5%
Bacillus anthracis
Protein fate
Protein folding and stabilization
IDP04384
(
show subtarget assignments
)
1
in_pdb
3PZS
Yes
YPO2368
218929459
pdxY
pyridoxamine kinase [Yersinia pestis CO9...
286
conserved gene; putative drug target function;
Phase 4: April 2009
3PZS
100%
Yersinia pestis
Biosynthesis of cofactors, prosthetic groups, and carriers
Pyridoxine
IDP02004
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0994c
56708086
MRP like protein [Francisella tularensis...
286
Conserved; Drug target functions
Phase 3: June 2008
2PH1
35.3%
Francisella tularensis
Cellular processes
Cell division
IDP01863
(
show subtarget assignments
)
1
cloned
No
GBAA5548
47778410
atpG
F0F1 ATP synthase subunit gamma [Bacillu...
286
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
2QE7
58.7%
Bacillus anthracis
Energy metabolism
ATP-proton motive force interconversion
IDP05677
(
show subtarget assignments
)
1
in_pdb
4EAE
No
lmo1068
16803108
-
hypothetical protein lmo1068 [Listeria m...
286
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
4EAE
65.4%
Listeria monocytogenes
IDP04405
(
show subtarget assignments
)
1
cloned
No
CPF_2987
110799346
stage 0 sporulation protein J [Clostridi...
286
conserved gene; putative drug target function;
Phase 4: April 2009
1VZ0
33.6%
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP91849
(
show subtarget assignments
)
8
selected
No
STER_1358
116628108
XRE family transcriptional regulator [St...
286
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus thermophilus
IDP90300
(
show subtarget assignments
)
8
in_pdb
4EIV
3QYQ
Yes
TGME49_118750
211967477
deoxyribose-phosphate aldolase, putative...
286
The deoxyribose phosphate aldolase-like gene TgPDA is recently described to be s...
Community Requests
3QYQ
96.5%
Toxoplasma gondii
IDP01682
(
show subtarget assignments
)
1
cloned
No
GBAA5104
47530405
D-alanyl-D-alanine carboxypeptidase fami...
286
Drug target motif; Drug target functions
Phase 3: June 2008
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP91460
(
show subtarget assignments
)
8
in_crystallization_trials
No
VV1_0095
27363579
Phage-related baseplate assembly protein...
286
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP00751
(
show subtarget assignments
)
8
purified
No
SACOL2117
57286333
fbaA
fructose-bisphosphate aldolase
286
Drug Target Function
Community Requests
3Q94
75.9%
Staphylococcus aureus
Energy metabolism
Glycolysis/gluconeogenesis
IDP00728
(
show subtarget assignments
)
1
cloned
No
SACOL2210
57284991
ABC transporter, ATP-binding protein
286
Conserved Gene / Pathway
Phase 2: March 2008
3GFO
32.2%
Staphylococcus aureus
Transport and binding proteins
Unknown substrate
IDP90839
(
show subtarget assignments
)
8
purified
No
Cj0641
15792001
ATP-NAD kinase, putative [Campylobacter ...
286
Predicted Essential
Community Requests
2AN1
31.9%
Campylobacter jejuni
IDP91485
(
show subtarget assignments
)
8
cloned
No
VP1699
28898473
transcriptional regulator ExsA [Vibrio p...
286
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3MKL
10.8%
Vibrio parahaemolyticus
IDP02528
(
show subtarget assignments
)
1
soluble
No
GBAA4405
47529699
folD
methylenetetrahydrofolate dehydrogenase/...
286
Essential; Drug target functions
Phase 3: June 2008
3P2O
51%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers
Folic acid
IDP91857
(
show subtarget assignments
)
8
selected
No
SPP_0211
225855925
MutR [Streptococcus pneumoniae P1031]
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus pneumoniae
IDP91856
(
show subtarget assignments
)
8
selected
No
SPH_0253
169834104
MutR [Streptococcus pneumoniae Hungary19...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus pneumoniae
IDP91843
(
show subtarget assignments
)
8
selected
No
Sez_0050
195977202
positive transcriptional regulator, MutR...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus equi
IDP91854
(
show subtarget assignments
)
8
expressed
No
SP_0141
15900079
transcriptional regulator [Streptococcus...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus pneumoniae
IDP91264
(
show subtarget assignments
)
8
cloned
No
NT05BA1100
49177922
protein export protein prsA [Bacillus an...
287
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3RFW
28.6%
Bacillus anthracis
Fatty acid and phospholipid metabolism: Degradation
IDP90793
(
show subtarget assignments
)
8
in_pdb
3UFG
3RF1
3RGL
Yes
Cj0704
15792053
glyQ
glycyl-tRNA synthetase subunit alpha [Ca...
287
Predicted Essential
Community Requests
3RF1
100%
Campylobacter jejuni
IDP91853
(
show subtarget assignments
)
8
selected
No
SZO_17730
225869330
transcriptional regulator [Streptococcus...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus equi
IDP01750
(
show subtarget assignments
)
1
in_pdb
3RJ4
3UXJ
3RZQ
3RZP
3S19
3UXV
3RJB
No
VC_0902
9655358
Vibrio cholerae O1 biovar eltor str. N16...
287
DRUG TARGET HOMOLOG
Phase 3: June 2008
3BP1
100%
Vibrio cholerae
N/A
N/A
IDP01685
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0757
56707872
galU
UTP--glucose-1-phosphate uridylyltransfe...
287
Conserved; Drug target functions
Phase 3: June 2008
2E3D
47.8%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP91848
(
show subtarget assignments
)
8
selected
No
STER_1530
116628259
XRE family transcriptional regulator [St...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus thermophilus
IDP01434
(
show subtarget assignments
)
1
purified
No
VC1944
15641946
PvcB protein
287
Conserved Gene / Pathway
Phase 2: March 2008
3EAT
46%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP04133
(
show subtarget assignments
)
1
cloned
No
CPF_1195
110798868
hpkA
sensor histidine kinase [Clostridium per...
287
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
25.8%
Clostridium perfringens
Regulatory functions
Other
IDP92087
(
show subtarget assignments
)
8
selected
No
TGME49_116330
237831005
iron-containing superoxide dismutase [To...
287
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2AWP
41.1%
Toxoplasma gondii
IDP92052
(
show subtarget assignments
)
8
selected
No
TGME49_053800
237840277
ribosomal protein L15, putative [Toxopla...
287
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
Toxoplasma gondii
IDP02545
(
show subtarget assignments
)
1
in_pdb
3P09
No
FTT0611c
56707736
beta-lactamase [Francisella tularensis s...
287
Drug Target
Phase 3: June 2008
3P09
100%
Francisella tularensis
Cellular processes
Toxin production and resistance
IDP05252
(
show subtarget assignments
)
1
soluble
No
lmo2854
16804891
-
hypothetical protein lmo2854 [Listeria m...
267
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
Cell envelope: Other
IDP02498
(
show subtarget assignments
)
1
cloned
No
FTT1556c
56708584
lepB
signal peptidase I [Francisella tularens...
287
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
1B12
33.4%
Francisella tularensis
Protein fate
Protein and peptide secretion and trafficking
IDP91842
(
show subtarget assignments
)
8
cloned
No
SPG_1268
194397142
positive transcriptional regulator MutRf...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus pneumoniae
IDP91846
(
show subtarget assignments
)
8
selected
No
SSU1789
253754475
DNA-binding protein [Streptococcus suis ...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus suis
IDP00597
(
show subtarget assignments
)
1
purified
No
YPO3909
16124041
murI
glutamate racemase
287
Conserved Gene / Pathway
Phase 2: March 2008
2JFN
71.4%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP04538
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05770
12329039
ospB
OspB, protein secreted by the Mxi-Spa se...
288
Shigella effector protein
Community Requests
Shigella flexneri
IDP91839
(
show subtarget assignments
)
8
selected
No
Spy49_0415
209558971
mutR
positive transcriptional regulator [Stre...
288
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus pyogenes
IDP91166
(
show subtarget assignments
)
8
in_pdb
3T4E
No
STM1359
16764710
aroE
shikimate 5-dehydrogenase
288
potential drug target /
Shikimate pathway enzyme
Community Requests
3T4E
100%
Salmonella enterica
IDP00224
(
show subtarget assignments
)
1
cloned
No
YPO3058
16123235
-
putative membrane protein
288
Virulence
Phase 1: October 2007
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP90904
(
show subtarget assignments
)
8
cloned
No
YPO0311
16120649
ubiA
4-hydroxybenzoate octaprenyltransferase ...
288
Predicted Essential
Community Requests
Yersinia pestis
IDP01890
(
show subtarget assignments
)
1
cloned
No
Cj0063c
15791455
ATPase, ParA family [Campylobacter jejun...
288
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
1HYQ
25.7%
Campylobacter jejuni
Cell envelope
Other
IDP05684
(
show subtarget assignments
)
1
in_pdb
3TNG
3U9E
3UF6
No
lmo1369
16803409
-
hypothetical protein lmo1369 [Listeria m...
288
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3TNG
100%
Listeria monocytogenes
Unclassified: Role category not yet assigned
IDP00447
(
show subtarget assignments
)
1
cloned
No
YPCD1.71c
16082759
yopJ
targeted effector protein
288
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cellular processes
Cell division
IDP00828
(
show subtarget assignments
)
1
expressed
No
SACOL2508
57285193
galU
UTP-glucose-1-phosphate uridylyltransfer...
288
Conserved Gene / Pathway
Phase 2: March 2008
2UX8
51.9%
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP01628
(
show subtarget assignments
)
1
cloned
No
CBU_1909
29542466
rpoH
RNA polymerase sigma-32 factor [Coxiella...
288
Conserved; Drug target functions
Phase 3: June 2008
3IYD
26.4%
Coxiella burnetii
Protein synthesis
Translation factors
IDP02612
(
show subtarget assignments
)
0
work_stopped
No
GBAA5170
50196964
dapF
diaminopimelate epimerase [Bacillus anth...
288
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
2OTN
100%
Bacillus anthracis
Amino acid biosynthesis
Aspartate family
IDP02499
(
show subtarget assignments
)
1
in_pdb
3I3O
3IJR
No
GBAA0748
47526031
short chain dehydrogenase [Bacillus anth...
288
Conserved; Essential; Involved in sporulation;
Phase 3: June 2008
3I3O
100%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP90417
(
show subtarget assignments
)
8
cloned
No
CT_504
3328941
hypothetical protein [Chlamydia trachoma...
288
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00128
(
show subtarget assignments
)
1
soluble
No
NT01ST3027
16765755
pdxK
mp65f07.r1 Soares_thymus_2NbMT Mus muscu...
288
Essential
Phase 1: October 2007
2DDM
65.6%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Pyridoxine
IDP04528
(
show subtarget assignments
)
1
expressed
No
STM2257_1_289
16765585
napH
quinol dehydrogenase membrane component ...
289
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05449
(
show subtarget assignments
)
1
cloned
No
lmo2595
16804633
-
hypothetical protein lmo2595 [Listeria m...
289
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP02096
(
show subtarget assignments
)
1
cloned
No
YPO0178
16120519
prk
phosphoribulokinase 1 [Yersinia pestis C...
289
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1A7J
49.5%
Yersinia pestis
Energy metabolism
Photosynthesis
IDP91852
(
show subtarget assignments
)
8
selected
No
SZO_12400
225868818
DNA-binding protein [Streptococcus equi ...
289
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus equi
IDP00524
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO0490
16120820
apaH
diadenosine tetraphosphatase
289
Conserved Gene / Pathway
Phase 2: March 2008
2DFJ
73.7%
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP01891
(
show subtarget assignments
)
1
purified
No
STM3464
16766752
prkB
putative phosphoribulokinase [Salmonella...
289
Conserved; Drug target functions
Phase 3: June 2008
1A7J
50.5%
Salmonella enterica
Energy metabolism
Sugars
IDP01731
(
show subtarget assignments
)
1
expressed
No
CBU_1222
29541792
dapA
dihydrodipicolinate synthase [Coxiella b...
289
Conserved; Drug target functions
Phase 3: June 2008
3QZE
55.2%
Coxiella burnetii
Amino acid biosynthesis
Aspartate family
IDP90715
(
show subtarget assignments
)
8
expressed
No
Cj0534
15791895
sucD
succinyl-CoA synthase, alpha subunit [Ca...
289
Predicted Essential
Community Requests
1JKJ
58.1%
Campylobacter jejuni
IDP91474
(
show subtarget assignments
)
8
expressed
No
VPA1346
28901201
putative targeted effector protein YopP ...
289
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP04639
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0556c
56707686
oxyR
oxidative stress transcriptional regulat...
289
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2H98
26.2%
Francisella tularensis
Regulatory functions
DNA interactions
IDP00784
(
show subtarget assignments
)
1
purified
No
SACOL0896
57284355
pathogenicity island protein
289
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
Cellular processes
Pathogenesis
IDP01471
(
show subtarget assignments
)
1
purified
No
VC2613
15642608
phosphoribulokinase
289
Conserved Gene / Pathway
Phase 2: March 2008
1A7J
51.6%
Vibrio cholerae
Energy metabolism
Sugars
IDP91170
(
show subtarget assignments
)
8
cloned
No
lmo2236
16804275
-
similar to oxidoreductase
289
potential drug target /
Shikimate pathway enzyme
Community Requests
3TNL
52.6%
Listeria monocytogenes
IDP90424
(
show subtarget assignments
)
8
cloned
No
CT_546
3328985
predicted OMP [Chlamydia trachomatis D/U...
289
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP02620
(
show subtarget assignments
)
1
cloned
No
lmo0205
16802251
plcB
phospholipase C [Listeria monocytogenes ...
289
Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; PMID:1143281...
Phase 3: June 2008
1AH7
32.5%
Listeria monocytogenes
Cellular processes
Toxin production and resistance
IDP04611
(
show subtarget assignments
)
1
cloned
No
BAS3754
49186753
sporulation sigma factor SigG [Bacillus ...
289
Proposed to be essential proteins
Phase 4: April 2009
1L0O
37%
Bacillus anthracis
IDP05048
(
show subtarget assignments
)
1
cloned
No
BA_4771
30259258
conserved hypothetical protein [Bacillus...
289
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP02797
(
show subtarget assignments
)
1
cloned
No
lmo2184
16804223
hypothetical protein lmo2184 [Listeria m...
290
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
2Q8P
47.2%
Listeria monocytogenes
Transport and binding proteins
Unknown substrate
IDP90742
(
show subtarget assignments
)
8
crystallized
No
Cj0947c
15792276
hydrolase, carbon-nitrogen family [Campy...
290
Predicted Essential
Community Requests
3IVZ
34.1%
Campylobacter jejuni
IDP05052
(
show subtarget assignments
)
1
expressed
No
CD0239
126697810
fliC
flagellin subunit [Clostridium difficile...
290
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3K8W
34.8%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP00813
(
show subtarget assignments
)
1
expressed
No
SACOL2004
57284879
leukocidin subunit precursor, putative
290
Conserved Gene / Pathway
Phase 2: March 2008
1LKF
41.2%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP05095
(
show subtarget assignments
)
1
soluble
No
BA_5481
30259944
conserved domain protein [Bacillus anthr...
290
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Domain
IDP00039
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_1960
30256617
aminoglycoside 6-adenylyltransferase, pu...
290
Virulence
Phase 1: October 2007
2PBE
37.9%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP02692
(
show subtarget assignments
)
1
expressed
No
FTT0503c
56707642
sucD
succinyl-CoA synthetase, alpha subunit [...
290
Conserved; Drug target functions
Phase 3: June 2008
1CQI
75.5%
Francisella tularensis
Energy metabolism
TCA cycle
IDP04015
(
show subtarget assignments
)
1
purified
No
VC0395
15640422
UTP--glucose-1-phosphate uridylyltransfe...
291
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3JUJ
58.1%
Vibrio cholerae
Purines, pyrimidines, nucleosides, and nucleotides
IDP91179
(
show subtarget assignments
)
8
expressed
No
y2283
22126168
hypothetical protein y2283 [Yersinia pes...
291
other biological interest /
Other biological interest
Community Requests
2PZ0
24.7%
Yersinia pestis
IDP91855
(
show subtarget assignments
)
8
selected
No
STER_1299
116628056
XRE family transcriptional regulator [St...
291
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus thermophilus
IDP05703
(
show subtarget assignments
)
1
cloned
No
lmo2578
16804616
-
hypothetical protein lmo2578 [Listeria m...
283
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3DS8
67.1%
Listeria monocytogenes
Hypothetical proteins: Conserved
IDP00137
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC_0959
9655418
VC0959
Vibrio cholerae O1 biovar eltor str. N16...
291
Virulence
Phase 1: October 2007
3NQR
29.6%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP91169
(
show subtarget assignments
)
8
in_pdb
3TNL
3TOZ
No
lmo0490
16802533
-
similar to shikimate 5-dehydrogenase
291
potential drug target /
Shikimate pathway enzyme
Community Requests
3TNL
100%
Listeria monocytogenes
IDP00301
(
show subtarget assignments
)
1
expressed
No
CBU_0983
291
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 2: March 2008
3NVT
10.7%
Coxiella burnetii
IDP02304
(
show subtarget assignments
)
1
cloned
No
GBAA0703
47525984
qoxA
quinol oxidase, subunit II [Bacillus ant...
291
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1FFT
33.7%
Bacillus anthracis
Energy metabolism
Electron transport
IDP00232
(
show subtarget assignments
)
1
cloned
No
YPO3480
16123626
-
conserved hypothetical protein
292
Virulence
Phase 1: October 2007
Yersinia pestis
Transport and binding proteins
Cations and iron carrying compounds
IDP01004
(
show subtarget assignments
)
1
in_pdb
3G0S
Yes
STM2489
16765809
dapA
dihydrodipicolinate synthase
292
Conserved Gene / Pathway
Phase 2: March 2008
3G0S
100%
Salmonella enterica
Amino acid biosynthesis
Aspartate family
IDP90721
(
show subtarget assignments
)
8
crystallized
No
YPO1610
16121878
aroE
shikimate 5-dehydrogenase [Yersinia pest...
292
Predicted Essential
Community Requests
1NPY
52.4%
Yersinia pestis
IDP04492
(
show subtarget assignments
)
1
cloned
No
YPO3834
218930837
pldA
phospholipase A [Yersinia pestis CO92]
292
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
1FW2
69.2%
Yersinia pestis
Fatty acid and phospholipid metabolism
Degradation
IDP00024
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_0039
33516921
Dimethyladenosine transferase (S-adenosy...
292
Virulence
Phase 1: October 2007
3GRR
37.7%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00045
(
show subtarget assignments
)
1
purified
No
BA_3111
30257692
aminoglycoside phosphotransferase family...
292
Virulence
Phase 1: October 2007
3LZH
17.8%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00774
(
show subtarget assignments
)
1
cloned
No
SACOL0597
57285613
chaperone protein HchA
292
Drug Target Function
Phase 2: March 2008
1IZY
54.1%
Staphylococcus aureus
Hypothetical proteins
Conserved
IDP90702
(
show subtarget assignments
)
8
expressed
No
Cj0134
15791522
thrB
homoserine kinase [Campylobacter jejuni ...
292
Predicted Essential
Community Requests
3HUL
30.2%
Campylobacter jejuni
IDP90663
(
show subtarget assignments
)
8
soluble
No
VC2157
15642156
dapA
dihydrodipicolinate synthase [Vibrio cho...
292
Predicted Essential
Community Requests
3G0S
59.6%
Vibrio cholerae
IDP91988
(
show subtarget assignments
)
8
in_pdb
4EXL
No
SpneCM_010100007640
298255458
phosphate-binding protein PstS 1 (PBP 1)...
292
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
4ECF
47.3%
Streptococcus pneumoniae
IDP91965
(
show subtarget assignments
)
8
cloned
No
SpneCM_010100004182
298254799
pneumococcal surface protein, putative [...
292
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2WW5
27.4%
Streptococcus pneumoniae
IDP04653
(
show subtarget assignments
)
1
expressed
No
FTT1503
56708541
xerC
integrase/recombinase XerC [Francisella ...
292
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1A0P
34.6%
Francisella tularensis
DNA metabolism
DNA replication, recombination, and repair
IDP05191
(
show subtarget assignments
)
1
purified
No
CD0265
126697837
fleN
flagellar number regulator [Clostridium ...
292
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1HYQ
27.4%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP02351
(
show subtarget assignments
)
1
cloned
No
FTT1112c
56708190
rpoH
RNA polymerase factor sigma-32 [Francise...
292
Drug Target
Phase 3: June 2008
1IW7
25%
Francisella tularensis
Cellular processesTranscription
Adaptations to atypical conditionsTranscription factors
IDP04536
(
show subtarget assignments
)
8
selected
No
CAC05826
12329095
spa32
Spa32, secreted by and component of the ...
292
Shigella effector protein
Community Requests
Shigella flexneri
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