Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04494 (show subtarget assignments)	1	expressed	No	VC0591	15640612	panC	pantoate--beta-alanine ligase [Vibrio ch...	293	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3Q10	57%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP05351 (show subtarget assignments)	1	soluble	No	CD1522	126699126		putative polysaccharide deacetylase [Clo...	293	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2W3Z	33%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02048 (show subtarget assignments)	1	expressed	No	STM3737	16767022		putative Zn-dependent hydrolase [Salmone...	293	Conserved; Drug target functions	Phase 3: June 2008	1JT1	30.7%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP05501 (show subtarget assignments)	1	in_crystallization_trials	No	CD0270	126697842	fliM	putative flagellar motor switch protein ...	293	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2HP7	15.7%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP00206 (show subtarget assignments)	1	soluble	No	YPO1706	16121966	-	putative heat shock protein	293	Virulence	Phase 1: October 2007	3CQB	28.7%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00469 (show subtarget assignments)	1	cloned	No	YPO0139	16120482	hslO	Hsp33-like chaperonin	293	Conserved Gene / Pathway	Phase 2: March 2008	1I7F	71%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP00183 (show subtarget assignments)	1	cloned	No	YPO0613	16120939	-	putative permease protein	293	Virulence	Phase 1: October 2007	2R6G	22.5%	Yersinia pestis

IDP90675 (show subtarget assignments)	8	cloned	No	YPO3861	16123996	rffH	glucose-1-phosphate thymidylyltransferas...	293	Predicted Essential	Community Requests	1MC3	86.7%	Yersinia pestis

IDP04222 (show subtarget assignments)	8	selected	No	CAC05827	12329096	spa33	Spa33, component of the Mxi-Spa secretio...	293	Shigella effector protein	Community Requests			Shigella flexneri

IDP01478 (show subtarget assignments)	1	purified	No	VC2772	15642765		ParB family protein	293	Conserved Gene / Pathway	Phase 2: March 2008	1VZ0	33.8%	Vibrio cholerae	Cellular processes	Cell division

IDP00742 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1276	57286013	tsf	elongation factor Ts	293	Drug Target Function	Phase 2: March 2008	3AGP	44%	Staphylococcus aureus	Protein synthesis	Translation factors

IDP91564 (show subtarget assignments)	8	in_crystallization_trials	No	BAB34271	13360307	ECs0848	hypothetical protein [Escherichia coli O...	293	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP05620 (show subtarget assignments)	1	cloned	No	CD0738	126698318		hypothetical protein CD0738 [Clostridium...	293	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP01399 (show subtarget assignments)	1	in_crystallization_trials	No	VC0771	15640790		vibriobactin-specific isochorismatase	293	Conserved Gene / Pathway	Phase 2: March 2008	2FQ1	44.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02624 (show subtarget assignments)	1	soluble	No	FTT1562	56708589	ispA	geranyltranstransferase [Francisella tul...	293	Conserved; Drug target functions	Phase 3: June 2008	2FOR	40.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP90526 (show subtarget assignments)	8	crystallized	No	YPO1106	16121406	ppnK	inorganic polyphosphate/ATP-NAD kinase [...	293	Predicted Essential	Community Requests	2AN1	83.6%	Yersinia pestis

IDP00670 (show subtarget assignments)	1	purified	No	SACOL1212	57285955	pyrB	aspartate carbamoyltransferase catalytic...	293	Drug Target Function	Phase 2: March 2008	2AT2	55.6%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04609 (show subtarget assignments)	1	soluble	No	BAS3712	49186711		ribosome-associated GTPase [Bacillus ant...	293	Proposed to be essential proteins	Phase 4: April 2009	1T9H	63.4%	Bacillus anthracis

IDP00584 (show subtarget assignments)	1	soluble	No	YPO0117	16120462	metF	5,10-methylenetetrahydrofolate reductase...	294	Virulence Associated Factor	Phase 2: March 2008	1ZP3	86.4%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01048 (show subtarget assignments)	1	in_pdb 3R3S	Yes	STM3157	16766457	yghA	oxidoreductase	294	Conserved Gene / Pathway	Phase 2: March 2008	3R3S	100%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP00989 (show subtarget assignments)	1	purified	No	STM2183	16765513	cdd	cytidine deaminase	294	Conserved Gene / Pathway	Phase 2: March 2008	1AF2	87.4%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP91172 (show subtarget assignments)	8	purified	No	PA1706	15596903	pcrV	type III secretion protein PcrV [Pseudom...	294	potential drug target / P. aeruginosa is an important clinical pathogen. PcrV is a critical component (t...	Community Requests	1R6F	35.4%	Pseudomonas aeruginosa

IDP01884 (show subtarget assignments)	1	soluble	No	Cj0042	15791441	flgD	flagellar basal body rod modification pr...	294	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP04568 (show subtarget assignments)	1	cloned	No	CPF_2087	110800786		stage III sporulation protein AA [Clostr...	294	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01481 (show subtarget assignments)	1	expressed	No	VCA0130	15600901		D-ribose transporter subunit RbsB	294	Conserved Gene / Pathway	Phase 2: March 2008	1DBP	65.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP91902 (show subtarget assignments)	8	selected	No	SpneCM_010100007650	298255460		phosphate ABC transporter, permease prot...	294	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3DHW	14.3%	Streptococcus pneumoniae

IDP91698 (show subtarget assignments)	8	selected	No	NP_002511	10835063	NPM1	nucleophosmin isoform 1 [Homo sapiens]	294	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2P1B	39.1%	Homo sapiens

IDP91346 (show subtarget assignments)	8	soluble	No	VV1_3141	27366406		hypothetical protein VV1_3141 [Vibrio vu...	294	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2HTA	35.7%	Vibrio vulnificus

IDP01159 (show subtarget assignments)	1	soluble	No	BA_4745	30259235		ABC transporter, ATP-binding protein	294	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	24.8%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP90530 (show subtarget assignments)	8	cloned	No	YPO3168	16123330	cyoE	protoheme IX farnesyltransferase	295	Predicted Essential	Community Requests			Yersinia pestis

IDP91465 (show subtarget assignments)	8	expressed	No	VPA1380	28901235		putative OspB protein [Vibrio parahaemol...	295	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio parahaemolyticus

IDP04677 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2371	47527666	dhbB	isochorismatase [Bacillus anthracis str....	295	putative drug target function;	Phase 4: April 2009	2FQ1	45.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP05732 (show subtarget assignments)	1	cloned	No	CD1205	126698801	ispA	geranyltranstransferase [Clostridium dif...	295	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2J1P	45.8%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone

IDP01740 (show subtarget assignments)	1	cloned	No	Cj1140	6968568	htrB	putative lipid A biosynthesis lauroyl ac...	295	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00777 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0665	57284261		iron compound ABC transporter, iron comp...	295	Conserved Gene / Pathway	Phase 2: March 2008	3EIW	27.5%	Staphylococcus aureus	Cell envelope	Other

IDP02824 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5152	47530456	gtaB	UTP-glucose-1-phosphate uridylyltransfer...	295	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2UX8	51.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05324 (show subtarget assignments)	1	cloned	No	CD3431	126701054		putative cobalamin biosynthesis kinase [...	295	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VIS	24.7%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02790 (show subtarget assignments)	1	cloned	No	FTT1525c	56708559		hypothetical protein FTT1525c [Francisel...	295	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02709 (show subtarget assignments)	1	purified	No	GBAA3964	47529254	tsf	elongation factor Ts [Bacillus anthracis...	295	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1EFU	47.1%	Bacillus anthracis	Protein synthesis	Translation factors

IDP00701 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0149	57285352	cap5N	capsular polysaccharide biosynthesis pro...	295	Conserved Gene / Pathway	Phase 2: March 2008	1Z45	22.4%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02682 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1502	29542061	era	GTP-binding protein Era [Coxiella burnet...	295	Conserved; Drug target functions	Phase 3: June 2008	1EGA	51.2%	Coxiella burnetii	Regulatory functions	RNA interactions

IDP90752 (show subtarget assignments)	8	soluble	No	Cj1098	15792423	pyrB	aspartate carbamoyltransferase catalytic...	295	Predicted Essential	Community Requests	2AT2	38.5%	Campylobacter jejuni

IDP04297 (show subtarget assignments)	1	in_pdb 4EG2	No	VC1231	15641244		cytidine deaminase [Vibrio cholerae O1 b...	295	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EG2	100%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP04546 (show subtarget assignments)	1	cloned	No	CPF_0213	110799242		putative iron chelate uptake ABC transpo...	295	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2Q8P	31.2%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP90543 (show subtarget assignments)	8	cloned	No	VC2182	15642181	ipk	4-diphosphocytidyl-2-C-methyl-D-erythrit...	295	Predicted Essential	Community Requests	1OJ4	58%	Vibrio cholerae

IDP91851 (show subtarget assignments)	8	selected	No	SDEG_1013	251782424		XRE family transcriptional regulator [St...	295	virulence/pathogenesis / Rgg proteins are peptide-ligand-responsive transcription factors that control vi...	Community Requests			Streptococcus dysgalactiae

IDP02294 (show subtarget assignments)	1	cloned	No	FTT0483c	56707625		hypothetical protein FTT0483c [Francisel...	295	Drug Target	Phase 3: June 2008	2YKR	39.7%	Francisella tularensis	Unknown function	General

IDP90669 (show subtarget assignments)	8	in_pdb 3PAJ	Yes	VC2422	15642419		quinolinate phosphoribosyltransferase [V...	296	Predicted Essential	Community Requests	3PAJ	100%	Vibrio cholerae

IDP04652 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1432c	56708477	ppnK	inorganic phosphate/ATP-NAD kinase [Fran...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2AN1	41.6%	Francisella tularensis

IDP04504 (show subtarget assignments)	1	cloned	No	VC2307	15642305		2-dehydropantoate 2-reductase [Vibrio ch...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KS9	43.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP91386 (show subtarget assignments)	8	cloned	No	VV1_1450	27364835		cell shape-determining protein [Vibrio v...	296	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2J5U	19.3%	Vibrio vulnificus

IDP04059 (show subtarget assignments)	1	expressed	No	VC1973	9656513		naphthoate synthase [Vibrio cholerae O1 ...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3H02	80.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00912 (show subtarget assignments)	1	soluble	No	STM0193	16763583	fhuD	iron-hydroxamate transporter substrate-b...	296	Conserved Gene / Pathway	Phase 2: March 2008	1ESZ	75%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP04510 (show subtarget assignments)	1	cloned	No	CPF_2272	110798867	era	GTP-binding protein Era [Clostridium per...	296	conserved gene; putative drug target function;	Phase 4: April 2009	3IEV	41.9%	Clostridium perfringens	Cellular processes	Cell division

IDP05557 (show subtarget assignments)	1	expressed	No	lmo1459	16803499	glyQ	glycyl-tRNA synthetase subunit alpha [Li...	263	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1J5W	54.4%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP04605 (show subtarget assignments)	1	in_crystallization_trials	No	BAS3689	49186688		ribosomal biogenesis GTPase [Bacillus an...	296	Proposed to be essential proteins	Phase 4: April 2009	1PUJ	67.2%	Bacillus anthracis

IDP92556 (show subtarget assignments)	8	selected	No	VV1_1076	27360618		HTH-type transcriptional regulator ilvY ...	296	potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...	Community Requests	2H99	21.6%	Vibrio vulnificus

IDP91939 (show subtarget assignments)	8	selected	No	SpneCM_010100003755	298254716		cation diffusion facilitator transporter...	296	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2QFI	15.9%	Streptococcus pneumoniae

IDP91515 (show subtarget assignments)	8	cloned	No	VV2_1587	27367932	malG	maltose transporter permease [Vibrio vul...	296	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2R6G	82.4%	Vibrio vulnificus

IDP02742 (show subtarget assignments)	1	expressed	No	GBAA2122	47527416		hypothetical protein GBAA2122 [Bacillus ...	296	Conserved; Involved in sporulation;	Phase 3: June 2008	2R44	42.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02693 (show subtarget assignments)	1	crystallized	No	FTT0185	56707350	ddlB	D-alanine--D-alanine ligase B [Francisel...	296	Conserved; Drug target functions	Phase 3: June 2008	3V4Z	43.9%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91526 (show subtarget assignments)	8	in_crystallization_trials	No	lpg1815	52842042	oxyR	hydrogen peroxide-inducible genes activa...	296	other biological interest / The Legionella pneumophila OxyR is a member of the LysR family that is no longer...	Community Requests	1I6A	28.4%	Legionella pneumophila

IDP04110 (show subtarget assignments)	1	expressed	No	YPO2440	218929529	yfeB	ATP-binding transport protein [Yersinia ...	296	virulence factor; conserved gene;	Phase 4: April 2009	3GFO	26.4%	Yersinia pestis	Unknown function	General

IDP04381 (show subtarget assignments)	8	selected	No	CAC05791	12329060		unnamed protein product [Shigella flexne...	296	Shigella effector protein	Community Requests	3MKL	8.4%	Shigella flexneri

IDP02445 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3411	16123560	speE	spermidine synthase [Yersinia pestis CO9...	296	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3ADN	78%	Yersinia pestis	Central intermediary metabolism	Polyamine biosynthesis

IDP01451 (show subtarget assignments)	1	purified	No	VC2305	15642303		outer membrane protein OmpK	296	Conserved Gene / Pathway	Phase 2: March 2008	1TLW	26%	Vibrio cholerae	Transport and binding proteins	Nucleosides, purines and pyrimidines

IDP90987 (show subtarget assignments)	8	crystallized	No	y1125	22125029		hypothetical protein y1125 [Yersinia pes...	297	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests	1VP5	57.2%	Yersinia pestis

IDP02093 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1970	47527265	thrB	homoserine kinase [Bacillus anthracis st...	297	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HUL	46.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP05241 (show subtarget assignments)	1	cloned	No	lmo1955	16803994	-	hypothetical protein lmo1955 [Listeria m...	297	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1A0P	43.8%	Listeria monocytogenes	Mobile and extrachromosomal element functions: Prophage functions

IDP90842 (show subtarget assignments)	8	selected	No	S0108	30061675	nadC	quinolinate phosphoribosyltransferase [S...	297	Predicted Essential	Community Requests	1QAP	85.9%	Shigella flexneri

IDP02022 (show subtarget assignments)	1	expressed	No	CBU_1351	29541916	folP	dihydropteroate synthase [Coxiella burne...	297	Conserved; Drug target functions	Phase 3: June 2008	3TR9	100%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01444 (show subtarget assignments)	1	soluble	No	VC2081	15642081		zinc ABC transporter, periplasmic zinc-b...	297	Conserved Gene / Pathway	Phase 2: March 2008	2OGW	44.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP91507 (show subtarget assignments)	8	expressed	No	VP1667	28898441		putative outer membrane protein PopN [Vi...	297	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1XKP	29.3%	Vibrio parahaemolyticus

IDP02587 (show subtarget assignments)	1	cloned	No	STM2571	16765891	murQ	N-acetylmuramic acid-6-phosphate etheras...	297	Conserved; Drug target functions	Phase 3: June 2008	1NRI	51.9%	Salmonella enterica	Unknown function	General

IDP05111 (show subtarget assignments)	1	cloned	No	CD2187	126699803		putative phage-related cell wall hydrola...	297	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3FI7	21.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00655 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0536	57285561	ksgA	dimethyladenosine transferase	297	Conserved Gene / Pathway	Phase 2: March 2008	3GRR	33.7%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP05624 (show subtarget assignments)	1	expressed	No	CD1146	126698741	mreC	putative rod shape-determining protein [...	297	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2J5U	25.3%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02279 (show subtarget assignments)	1	crystallized	No	FTT1164c	56708234	era	GTP-binding protein Era [Francisella tul...	297	Drug Target	Phase 3: June 2008	1EGA	48.5%	Francisella tularensis	Cellular processesRegulatory functions	Cell divisionRNA interactions

IDP02177 (show subtarget assignments)	1	soluble	No	FTT0063	56707242	atpG	F0F1 ATP synthase subunit gamma [Francis...	298	Conserved; Drug target functions	Phase 3: June 2008	3OAA	49.7%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP04548 (show subtarget assignments)	1	cloned	No	CPF_2413	110801184		ABC transporter, substrate-binding prote...	298	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2O1E	36.4%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP00964 (show subtarget assignments)	0	work_stopped	No	STM1439	16764787	ydhF	putative aldo/keto reductase	298	Conserved Gene / Pathway	Phase 2: March 2008	1OG6	88.9%	Salmonella enterica	Unknown function	General

IDP05691 (show subtarget assignments)	1	cloned	No	lmo1800	16803840	-	hypothetical protein lmo1800 [Listeria m...	298	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1YWF	25.8%	Listeria monocytogenes	Energy metabolism: Sugars

IDP05232 (show subtarget assignments)	1	in_pdb 3TX1	No	lmo1420	16803460	-	hypothetical protein lmo1420 [Listeria m...	298	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3TX1	100%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90711 (show subtarget assignments)	8	in_pdb 3M5V 3LER	No	Cj0806	15792144	dapA	dihydrodipicolinate synthase [Campylobac...	298	Predicted Essential	Community Requests	3M5V	100%	Campylobacter jejuni

IDP01462 (show subtarget assignments)	1	soluble	No	VC2462	15642458		signal peptidase I	298	Drug Target Function	Phase 2: March 2008	1B12	46.6%	Vibrio cholerae	Protein fate	Protein and peptide secretion and trafficking

IDP01379 (show subtarget assignments)	1	purified	No	VC0474	15640501		iron-regulated virulence regulatory prot...	298	Conserved Gene / Pathway	Phase 2: March 2008	3SZP	27.2%	Vibrio cholerae	Regulatory functions	Other

IDP90690 (show subtarget assignments)	8	purified	No	Cj1196c	15792520	gpsA	NAD(P)H-dependent glycerol-3-phosphate d...	298	Predicted Essential	Community Requests	1Z82	35.8%	Campylobacter jejuni

IDP04671 (show subtarget assignments)	1	soluble	No	GBAA1416	47526688	ilvE-1	branched-chain amino acid aminotransfera...	298	conserved gene; putative drug target function;	Phase 4: April 2009	1WRV	40.3%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP00035 (show subtarget assignments)	1	soluble	No	BA_1589	30255889		macrolide 2-phosphotransferase, putative...	298	Virulence	Phase 1: October 2007	3LZH	17.8%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02346 (show subtarget assignments)	1	cloned	No	GBAA2832	47528125	dapA-1	dihydrodipicolinate synthase [Bacillus a...	298	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3NA8	34.2%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP90801 (show subtarget assignments)	8	soluble	No	Cj1597	15792902	hisG	ATP phosphoribosyltransferase [Campyloba...	299	Predicted Essential	Community Requests	1H3D	66.2%	Campylobacter jejuni

IDP00554 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1549	16121822	hisG	ATP phosphoribosyltransferase	299	Virulence Associated Factor	Phase 2: March 2008	1H3D	88%	Yersinia pestis	Amino acid biosynthesis	Histidine family

IDP90192 (show subtarget assignments)	8	cloned	No	AAM13635.1	20153174	CPXV196 CDS	CPXV196 protein	299	serine-threonine kinase	Community Requests	2KTY	40.7%	Cowpox virus	Unknown function	0

IDP00051 (show subtarget assignments)	1	in_pdb 3EDN	Yes	BA_3469	30258008		phenazine biosynthesis protein, PhzF fam...	299	Virulence	Phase 1: October 2007	3EDN	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP90560 (show subtarget assignments)	8	in_crystallization_trials	No	YPO2014	16122257	ipk	4-diphosphocytidyl-2-C-methyl-D-erythrit...	299	Predicted Essential	Community Requests	1OJ4	70.9%	Yersinia pestis

IDP04084 (show subtarget assignments)	1	cloned	No	VC2561	15642556		uroporphyrin-III C-methyltransferase [Vi...	299	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1PJQ	50.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00446 (show subtarget assignments)	1	purified	No	YPO0892	16121197	xerD	site-specific tyrosine recombinase XerD ...	299	Conserved Gene / Pathway	Phase 2: March 2008	1A0P	80.9%	Yersinia pestis	DNA metabolism	DNA replication, recombination, and repair

IDP91786 (show subtarget assignments)	8	selected	No	AAA98349	153077	vgh	vgh [Staphylococcus aureus]	299	drug resistance / Hydrolase inactivating the B components of virginiamycin-like antibiotics	Community Requests	2Z2N	99.3%	Staphylococcus aureus

IDP00830 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2544	57285226	sdaAA	L-serine dehydratase, iron-sulfur-depend...	299	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Energy metabolism	Amino acids and amines

IDP00442 (show subtarget assignments)	1	soluble	No	YPO2211	16122439	trpH	hypothetical protein YPO2211	299	Conserved Gene / Pathway	Phase 2: March 2008	2YB1	38.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04494
(show subtarget assignments)

1

expressed

No

VC0591

15640612

panC

pantoate--beta-alanine ligase [Vibrio ch...

293

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3Q10

57%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP05351
(show subtarget assignments)

1

soluble

No

CD1522

126699126

putative polysaccharide deacetylase [Clo...

293

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2W3Z

33%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02048
(show subtarget assignments)

1

expressed

No

STM3737

16767022

putative Zn-dependent hydrolase [Salmone...

293

Conserved; Drug target functions

Phase 3: June 2008

1JT1

30.7%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP05501
(show subtarget assignments)

1

in_crystallization_trials

No

CD0270

126697842

fliM

putative flagellar motor switch protein ...

293

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2HP7

15.7%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP00206
(show subtarget assignments)

1

soluble

No

YPO1706

16121966

-

putative heat shock protein

293

Virulence

Phase 1: October 2007

3CQB

28.7%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00469
(show subtarget assignments)

1

cloned

No

YPO0139

16120482

hslO

Hsp33-like chaperonin

293

Conserved Gene / Pathway

Phase 2: March 2008

1I7F

71%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP00183
(show subtarget assignments)

1

cloned

No

YPO0613

16120939

-

putative permease protein

293

Virulence

Phase 1: October 2007

2R6G

22.5%

Yersinia pestis

IDP90675
(show subtarget assignments)

8

cloned

No

YPO3861

16123996

rffH

glucose-1-phosphate thymidylyltransferas...

293

Predicted Essential

Community Requests

1MC3

86.7%

Yersinia pestis

IDP04222
(show subtarget assignments)

8

selected

No

CAC05827

12329096

spa33

Spa33, component of the Mxi-Spa secretio...

293

Shigella effector protein

Community Requests

Shigella flexneri

IDP01478
(show subtarget assignments)

1

purified

No

VC2772

15642765

ParB family protein

293

Conserved Gene / Pathway

Phase 2: March 2008

1VZ0

33.8%

Vibrio cholerae

Cellular processes

Cell division

IDP00742
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1276

57286013

tsf

elongation factor Ts

293

Drug Target Function

Phase 2: March 2008

3AGP

44%

Staphylococcus aureus

Protein synthesis

Translation factors

IDP91564
(show subtarget assignments)

8

in_crystallization_trials

No

BAB34271

13360307

ECs0848

hypothetical protein [Escherichia coli O...

293

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP05620
(show subtarget assignments)

1

cloned

No

CD0738

126698318

hypothetical protein CD0738 [Clostridium...

293

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP01399
(show subtarget assignments)

1

in_crystallization_trials

No

VC0771

15640790

vibriobactin-specific isochorismatase

293

Conserved Gene / Pathway

Phase 2: March 2008

2FQ1

44.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02624
(show subtarget assignments)

1

soluble

No

FTT1562

56708589

ispA

geranyltranstransferase [Francisella tul...

293

Conserved; Drug target functions

Phase 3: June 2008

2FOR

40.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP90526
(show subtarget assignments)

8

crystallized

No

YPO1106

16121406

ppnK

inorganic polyphosphate/ATP-NAD kinase [...

293

Predicted Essential

Community Requests

2AN1

83.6%

Yersinia pestis

IDP00670
(show subtarget assignments)

1

purified

No

SACOL1212

57285955

pyrB

aspartate carbamoyltransferase catalytic...

293

Drug Target Function

Phase 2: March 2008

2AT2

55.6%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04609
(show subtarget assignments)

1

soluble

No

BAS3712

49186711

ribosome-associated GTPase [Bacillus ant...

293

Proposed to be essential proteins

Phase 4: April 2009

1T9H

63.4%

Bacillus anthracis

IDP00584
(show subtarget assignments)

1

soluble

No

YPO0117

16120462

metF

5,10-methylenetetrahydrofolate reductase...

294

Virulence Associated Factor

Phase 2: March 2008

1ZP3

86.4%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01048
(show subtarget assignments)

1

in_pdb
3R3S

Yes

STM3157

16766457

yghA

oxidoreductase

294

Conserved Gene / Pathway

Phase 2: March 2008

3R3S

100%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP00989
(show subtarget assignments)

1

purified

No

STM2183

16765513

cdd

cytidine deaminase

294

Conserved Gene / Pathway

Phase 2: March 2008

1AF2

87.4%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP91172
(show subtarget assignments)

8

purified

No

PA1706

15596903

pcrV

type III secretion protein PcrV [Pseudom...

294

potential drug target / P. aeruginosa is an important clinical pathogen. PcrV is a critical component (t...

Community Requests

1R6F

35.4%

Pseudomonas aeruginosa

IDP01884
(show subtarget assignments)

1

soluble

No

Cj0042

15791441

flgD

flagellar basal body rod modification pr...

294

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP04568
(show subtarget assignments)

1

cloned

No

CPF_2087

110800786

stage III sporulation protein AA [Clostr...

294

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01481
(show subtarget assignments)

1

expressed

No

VCA0130

15600901

D-ribose transporter subunit RbsB

294

Conserved Gene / Pathway

Phase 2: March 2008

1DBP

65.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP91902
(show subtarget assignments)

8

selected

No

SpneCM_010100007650

298255460

phosphate ABC transporter, permease prot...

294

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3DHW

14.3%

Streptococcus pneumoniae

IDP91698
(show subtarget assignments)

8

selected

No

NP_002511

10835063

NPM1

nucleophosmin isoform 1 [Homo sapiens]

294

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2P1B

39.1%

Homo sapiens

IDP91346
(show subtarget assignments)

8

soluble

No

VV1_3141

27366406

hypothetical protein VV1_3141 [Vibrio vu...

294

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2HTA

35.7%

Vibrio vulnificus

IDP01159
(show subtarget assignments)

1

soluble

No

BA_4745

30259235

ABC transporter, ATP-binding protein

294

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

24.8%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP90530
(show subtarget assignments)

8

cloned

No

YPO3168

16123330

cyoE

protoheme IX farnesyltransferase

295

Predicted Essential

Community Requests

Yersinia pestis

IDP91465
(show subtarget assignments)

8

expressed

No

VPA1380

28901235

putative OspB protein [Vibrio parahaemol...

295

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio parahaemolyticus

IDP04677
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2371

47527666

dhbB

isochorismatase [Bacillus anthracis str....

295

putative drug target function;

Phase 4: April 2009

2FQ1

45.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP05732
(show subtarget assignments)

1

cloned

No

CD1205

126698801

ispA

geranyltranstransferase [Clostridium dif...

295

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2J1P

45.8%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone

IDP01740
(show subtarget assignments)

1

cloned

No

Cj1140

6968568

htrB

putative lipid A biosynthesis lauroyl ac...

295

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00777
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0665

57284261

iron compound ABC transporter, iron comp...

295

Conserved Gene / Pathway

Phase 2: March 2008

3EIW

27.5%

Staphylococcus aureus

Cell envelope

Other

IDP02824
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5152

47530456

gtaB

UTP-glucose-1-phosphate uridylyltransfer...

295

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2UX8

51.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05324
(show subtarget assignments)

1

cloned

No

CD3431

126701054

putative cobalamin biosynthesis kinase [...

295

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VIS

24.7%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02790
(show subtarget assignments)

1

cloned

No

FTT1525c

56708559

hypothetical protein FTT1525c [Francisel...

295

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02709
(show subtarget assignments)

1

purified

No

GBAA3964

47529254

tsf

elongation factor Ts [Bacillus anthracis...

295

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1EFU

47.1%

Bacillus anthracis

Protein synthesis

Translation factors

IDP00701
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0149

57285352

cap5N

capsular polysaccharide biosynthesis pro...

295

Conserved Gene / Pathway

Phase 2: March 2008

1Z45

22.4%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02682
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1502

29542061

era

GTP-binding protein Era [Coxiella burnet...

295

Conserved; Drug target functions

Phase 3: June 2008

1EGA

51.2%

Coxiella burnetii

Regulatory functions

RNA interactions

IDP90752
(show subtarget assignments)

8

soluble

No

Cj1098

15792423

pyrB

aspartate carbamoyltransferase catalytic...

295

Predicted Essential

Community Requests

2AT2

38.5%

Campylobacter jejuni

IDP04297
(show subtarget assignments)

1

in_pdb
4EG2

No

VC1231

15641244

cytidine deaminase [Vibrio cholerae O1 b...

295

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EG2

100%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP04546
(show subtarget assignments)

1

cloned

No

CPF_0213

110799242

putative iron chelate uptake ABC transpo...

295

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2Q8P

31.2%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP90543
(show subtarget assignments)

8

cloned

No

VC2182

15642181

ipk

4-diphosphocytidyl-2-C-methyl-D-erythrit...

295

Predicted Essential

Community Requests

1OJ4

58%

Vibrio cholerae

IDP91851
(show subtarget assignments)

8

selected

No

SDEG_1013

251782424

XRE family transcriptional regulator [St...

295

virulence/pathogenesis / Rgg proteins are peptide-ligand-responsive transcription factors that control vi...

Community Requests

Streptococcus dysgalactiae

IDP02294
(show subtarget assignments)

1

cloned

No

FTT0483c

56707625

hypothetical protein FTT0483c [Francisel...

295

Drug Target

Phase 3: June 2008

2YKR

39.7%

Francisella tularensis

Unknown function

General

IDP90669
(show subtarget assignments)

8

in_pdb
3PAJ

Yes

VC2422

15642419

quinolinate phosphoribosyltransferase [V...

296

Predicted Essential

Community Requests

3PAJ

100%

Vibrio cholerae

IDP04652
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1432c

56708477

ppnK

inorganic phosphate/ATP-NAD kinase [Fran...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2AN1

41.6%

Francisella tularensis

IDP04504
(show subtarget assignments)

1

cloned

No

VC2307

15642305

2-dehydropantoate 2-reductase [Vibrio ch...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KS9

43.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP91386
(show subtarget assignments)

8

cloned

No

VV1_1450

27364835

cell shape-determining protein [Vibrio v...

296

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2J5U

19.3%

Vibrio vulnificus

IDP04059
(show subtarget assignments)

1

expressed

No

VC1973

9656513

naphthoate synthase [Vibrio cholerae O1 ...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3H02

80.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00912
(show subtarget assignments)

1

soluble

No

STM0193

16763583

fhuD

iron-hydroxamate transporter substrate-b...

296

Conserved Gene / Pathway

Phase 2: March 2008

1ESZ

75%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP04510
(show subtarget assignments)

1

cloned

No

CPF_2272

110798867

era

GTP-binding protein Era [Clostridium per...

296

conserved gene; putative drug target function;

Phase 4: April 2009

3IEV

41.9%

Clostridium perfringens

Cellular processes

Cell division

IDP05557
(show subtarget assignments)

1

expressed

No

lmo1459

16803499

glyQ

glycyl-tRNA synthetase subunit alpha [Li...

263

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1J5W

54.4%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP04605
(show subtarget assignments)

1

in_crystallization_trials

No

BAS3689

49186688

ribosomal biogenesis GTPase [Bacillus an...

296

Proposed to be essential proteins

Phase 4: April 2009

1PUJ

67.2%

Bacillus anthracis

IDP92556
(show subtarget assignments)

8

selected

No

VV1_1076

27360618

HTH-type transcriptional regulator ilvY ...

296

potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...

Community Requests

2H99

21.6%

Vibrio vulnificus

IDP91939
(show subtarget assignments)

8

selected

No

SpneCM_010100003755

298254716

cation diffusion facilitator transporter...

296

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2QFI

15.9%

Streptococcus pneumoniae

IDP91515
(show subtarget assignments)

8

cloned

No

VV2_1587

27367932

malG

maltose transporter permease [Vibrio vul...

296

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2R6G

82.4%

Vibrio vulnificus

IDP02742
(show subtarget assignments)

1

expressed

No

GBAA2122

47527416

hypothetical protein GBAA2122 [Bacillus ...

296

Conserved; Involved in sporulation;

Phase 3: June 2008

2R44

42.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02693
(show subtarget assignments)

1

crystallized

No

FTT0185

56707350

ddlB

D-alanine--D-alanine ligase B [Francisel...

296

Conserved; Drug target functions

Phase 3: June 2008

3V4Z

43.9%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91526
(show subtarget assignments)

8

in_crystallization_trials

No

lpg1815

52842042

oxyR

hydrogen peroxide-inducible genes activa...

296

other biological interest / The Legionella pneumophila OxyR is a member of the LysR family that is no longer...

Community Requests

1I6A

28.4%

Legionella pneumophila

IDP04110
(show subtarget assignments)

1

expressed

No

YPO2440

218929529

yfeB

ATP-binding transport protein [Yersinia ...

296

virulence factor; conserved gene;

Phase 4: April 2009

3GFO

26.4%

Yersinia pestis

Unknown function

General

IDP04381
(show subtarget assignments)

8

selected

No

CAC05791

12329060

unnamed protein product [Shigella flexne...

296

Shigella effector protein

Community Requests

3MKL

8.4%

Shigella flexneri

IDP02445
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3411

16123560

speE

spermidine synthase [Yersinia pestis CO9...

296

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3ADN

78%

Yersinia pestis

Central intermediary metabolism

Polyamine biosynthesis

IDP01451
(show subtarget assignments)

1

purified

No

VC2305

15642303

outer membrane protein OmpK

296

Conserved Gene / Pathway

Phase 2: March 2008

1TLW

26%

Vibrio cholerae

Transport and binding proteins

Nucleosides, purines and pyrimidines

IDP90987
(show subtarget assignments)

8

crystallized

No

y1125

22125029

hypothetical protein y1125 [Yersinia pes...

297

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

1VP5

57.2%

Yersinia pestis

IDP02093
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1970

47527265

thrB

homoserine kinase [Bacillus anthracis st...

297

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HUL

46.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP05241
(show subtarget assignments)

1

cloned

No

lmo1955

16803994

-

hypothetical protein lmo1955 [Listeria m...

297

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1A0P

43.8%

Listeria monocytogenes

Mobile and extrachromosomal element functions: Prophage functions

IDP90842
(show subtarget assignments)

8

selected

No

S0108

30061675

nadC

quinolinate phosphoribosyltransferase [S...

297

Predicted Essential

Community Requests

1QAP

85.9%

Shigella flexneri

IDP02022
(show subtarget assignments)

1

expressed

No

CBU_1351

29541916

folP

dihydropteroate synthase [Coxiella burne...

297

Conserved; Drug target functions

Phase 3: June 2008

3TR9

100%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01444
(show subtarget assignments)

1

soluble

No

VC2081

15642081

zinc ABC transporter, periplasmic zinc-b...

297

Conserved Gene / Pathway

Phase 2: March 2008

2OGW

44.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP91507
(show subtarget assignments)

8

expressed

No

VP1667

28898441

putative outer membrane protein PopN [Vi...

297

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1XKP

29.3%

Vibrio parahaemolyticus

IDP02587
(show subtarget assignments)

1

cloned

No

STM2571

16765891

murQ

N-acetylmuramic acid-6-phosphate etheras...

297

Conserved; Drug target functions

Phase 3: June 2008

1NRI

51.9%

Salmonella enterica

Unknown function

General

IDP05111
(show subtarget assignments)

1

cloned

No

CD2187

126699803

putative phage-related cell wall hydrola...

297

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3FI7

21.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00655
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0536

57285561

ksgA

dimethyladenosine transferase

297

Conserved Gene / Pathway

Phase 2: March 2008

3GRR

33.7%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP05624
(show subtarget assignments)

1

expressed

No

CD1146

126698741

mreC

putative rod shape-determining protein [...

297

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2J5U

25.3%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02279
(show subtarget assignments)

1

crystallized

No

FTT1164c

56708234

era

GTP-binding protein Era [Francisella tul...

297

Drug Target

Phase 3: June 2008

1EGA

48.5%

Francisella tularensis

Cellular processesRegulatory functions

Cell divisionRNA interactions

IDP02177
(show subtarget assignments)

1

soluble

No

FTT0063

56707242

atpG

F0F1 ATP synthase subunit gamma [Francis...

298

Conserved; Drug target functions

Phase 3: June 2008

3OAA

49.7%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP04548
(show subtarget assignments)

1

cloned

No

CPF_2413

110801184

ABC transporter, substrate-binding prote...

298

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2O1E

36.4%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP00964
(show subtarget assignments)

0

work_stopped

No

STM1439

16764787

ydhF

putative aldo/keto reductase

298

Conserved Gene / Pathway

Phase 2: March 2008

1OG6

88.9%

Salmonella enterica

Unknown function

General

IDP05691
(show subtarget assignments)

1

cloned

No

lmo1800

16803840

-

hypothetical protein lmo1800 [Listeria m...

298

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1YWF

25.8%

Listeria monocytogenes

Energy metabolism: Sugars

IDP05232
(show subtarget assignments)

1

in_pdb
3TX1

No

lmo1420

16803460

-

hypothetical protein lmo1420 [Listeria m...

298

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3TX1

100%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90711
(show subtarget assignments)

8

in_pdb
3M5V
3LER

No

Cj0806

15792144

dapA

dihydrodipicolinate synthase [Campylobac...

298

Predicted Essential

Community Requests

3M5V

100%

Campylobacter jejuni

IDP01462
(show subtarget assignments)

1

soluble

No

VC2462

15642458

signal peptidase I

298

Drug Target Function

Phase 2: March 2008

1B12

46.6%

Vibrio cholerae

Protein fate

Protein and peptide secretion and trafficking

IDP01379
(show subtarget assignments)

1

purified

No

VC0474

15640501

iron-regulated virulence regulatory prot...

298

Conserved Gene / Pathway

Phase 2: March 2008

3SZP

27.2%

Vibrio cholerae

Regulatory functions

Other

IDP90690
(show subtarget assignments)

8

purified

No

Cj1196c

15792520

gpsA

NAD(P)H-dependent glycerol-3-phosphate d...

298

Predicted Essential

Community Requests

1Z82

35.8%

Campylobacter jejuni

IDP04671
(show subtarget assignments)

1

soluble

No

GBAA1416

47526688

ilvE-1

branched-chain amino acid aminotransfera...

298

conserved gene; putative drug target function;

Phase 4: April 2009

1WRV

40.3%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP00035
(show subtarget assignments)

1

soluble

No

BA_1589

30255889

macrolide 2-phosphotransferase, putative...

298

Virulence

Phase 1: October 2007

3LZH

17.8%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02346
(show subtarget assignments)

1

cloned

No

GBAA2832

47528125

dapA-1

dihydrodipicolinate synthase [Bacillus a...

298

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3NA8

34.2%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP90801
(show subtarget assignments)

8

soluble

No

Cj1597

15792902

hisG

ATP phosphoribosyltransferase [Campyloba...

299

Predicted Essential

Community Requests

1H3D

66.2%

Campylobacter jejuni

IDP00554
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1549

16121822

hisG

ATP phosphoribosyltransferase

299

Virulence Associated Factor

Phase 2: March 2008

1H3D

88%

Yersinia pestis

Amino acid biosynthesis

Histidine family

IDP90192
(show subtarget assignments)

8

cloned

No

AAM13635.1

20153174

CPXV196 CDS

CPXV196 protein

299

serine-threonine kinase

Community Requests

2KTY

40.7%

Cowpox virus

Unknown function

0

IDP00051
(show subtarget assignments)

1

in_pdb
3EDN

Yes

BA_3469

30258008

phenazine biosynthesis protein, PhzF fam...

299

Virulence

Phase 1: October 2007

3EDN

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP90560
(show subtarget assignments)

8

in_crystallization_trials

No

YPO2014

16122257

ipk

4-diphosphocytidyl-2-C-methyl-D-erythrit...

299

Predicted Essential

Community Requests

1OJ4

70.9%

Yersinia pestis

IDP04084
(show subtarget assignments)

1

cloned

No

VC2561

15642556

uroporphyrin-III C-methyltransferase [Vi...

299

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1PJQ

50.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00446
(show subtarget assignments)

1

purified

No

YPO0892

16121197

xerD

site-specific tyrosine recombinase XerD ...

299

Conserved Gene / Pathway

Phase 2: March 2008

1A0P

80.9%

Yersinia pestis

DNA metabolism

DNA replication, recombination, and repair

IDP91786
(show subtarget assignments)

8

selected

No

AAA98349

153077

vgh

vgh [Staphylococcus aureus]

299

drug resistance / Hydrolase inactivating the B components of virginiamycin-like antibiotics

Community Requests

2Z2N

99.3%

Staphylococcus aureus

IDP00830
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2544

57285226

sdaAA

L-serine dehydratase, iron-sulfur-depend...

299

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Energy metabolism

Amino acids and amines

IDP00442
(show subtarget assignments)

1

soluble

No

YPO2211

16122439

trpH

hypothetical protein YPO2211

299

Conserved Gene / Pathway

Phase 2: March 2008

2YB1

38.5%

Yersinia pestis

Unclassified

Role category not yet assigned