Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02704 (show subtarget assignments)	1	soluble	No	lmo0007	16802055	gyrA	DNA gyrase subunit A [Listeria monocytog...	842	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	2XCO	40.4%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP00684 (show subtarget assignments)	1	cloned	No	SACOL1926	57286273	mutY	A/G-specific adenine glycosylase	345	Drug Target Function	Phase 2: March 2008	3FSP	45.8%	Staphylococcus aureus	DNA metabolism	DNA replication, recombination, and repair

IDP02606 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0006	16802054	gyrB	DNA gyrase subunit B [Listeria monocytog...	646	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	1EI1	31.4%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP00676 (show subtarget assignments)	1	expressed	No	SACOL1492	57284593	nth	endonuclease III	219	Drug Target Function	Phase 2: March 2008	1ORN	62.1%	Staphylococcus aureus	DNA metabolism	DNA replication, recombination, and repair

IDP02504 (show subtarget assignments)	1	purified	No	FTT1578c	56708604	ung	uracil-DNA glycosylase [Francisella tula...	220	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1EUG	58.6%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP02481 (show subtarget assignments)	1	cloned	No	Cj1139c	15792464		putative galactosyltransferase [Campylob...	303	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3BCV	24.1%	Campylobacter jejuni	DNA metabolism	DNA replication, recombination, and repair

IDP02479 (show subtarget assignments)	1	cloned	No	lmo1287	16803327	parC	DNA topoisomerase IV subunit A [Listeria...	819	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	2INR	41.8%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP02446 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0287	16802333		hypothetical protein lmo0287 [Listeria m...	237	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2OQR	48.1%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP05235 (show subtarget assignments)	1	cloned	No	lmo1532	16803572	ruvB	Holliday junction DNA helicase B [Lister...	335	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3PFI	55.2%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05236 (show subtarget assignments)	1	crystallized	No	lmo1533	16803573	ruvA	hypothetical protein lmo1533 [Listeria m...	201	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1IXR	34.8%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05233 (show subtarget assignments)	1	cloned	No	lmo1455	16803495	dnaG	DNA primase [Listeria monocytogenes EGD-...	626	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2AU3	21.7%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05229 (show subtarget assignments)	1	cloned	No	lmo1286	16803326	parE	DNA topoisomerase IV subunit B [Listeria...	655	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1EI1	29.8%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05220 (show subtarget assignments)	1	cloned	No	Cj1101	6968529	-	putative integral membrane protein [Camp...	670	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1PJR	36.6%	Campylobacter jejuni	DNA metabolism: DNA replication, recombination, and repair

IDP05559 (show subtarget assignments)	1	soluble	No	lmo1811	16803851	-	hypothetical protein lmo1811 [Listeria m...	697	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GM5	40.3%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05073 (show subtarget assignments)	1	expressed	No	Cj0562	6968026	dnaB	gamma-glutamyl phosphate reductase [Camp...	439	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2VYE	37.1%	Campylobacter jejuni	DNA metabolism: DNA replication, recombination, and repair

IDP05546 (show subtarget assignments)	1	cloned	No	lmo0054	16802102	dnaC	replicative DNA helicase [Listeria monoc...	450	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 5: 2010	2R6A	77.1%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05075 (show subtarget assignments)	1	cloned	No	lmo0466	16802510	-	hypothetical protein lmo0466 [Listeria m...	576	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010			Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05084 (show subtarget assignments)	1	in_crystallization_trials	No	Z4803	12518085		putative ATP-dependent DNA helicase (tog...	202	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1OYW	33.7%	Escherichia coli	DNA metabolism: DNA replication, recombination, and repair

IDP05573 (show subtarget assignments)	1	selected	No	BAS4798	49187788	-	cell surface protein, anchor [Bacillus a...	2025	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	DNA metabolism: DNA replication, recombination, and repair

IDP91277 (show subtarget assignments)	8	soluble	No	NT05BA4403	49181145		conserved hypothetical protein [Bacillus...	336	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1JQJ	17.3%	Bacillus anthracis	DNA metabolism: DNA replication, recombination, and repair

IDP91271 (show subtarget assignments)	8	expressed	No	NT05BA3690	49180451		prophage LambdaBa01, positive control fa...	167	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Bacillus anthracis	DNA metabolism: DNA replication, recombination, and repair

IDP91261 (show subtarget assignments)	8	soluble	No	NT05BA0041	49176992		DNA polymerase III, delta prime subunit ...	327	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1A5T	20.2%	Bacillus anthracis	DNA metabolism: DNA replication, recombination, and repair

IDP05336 (show subtarget assignments)	1	soluble	No	Cj0799c	6968240	ruvA	hypothetical protein Cj0794 [Campylobact...	183	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1IXR	32.5%	Campylobacter jejuni	DNA metabolism: DNA replication, recombination, and repair

IDP05323 (show subtarget assignments)	1	cloned	No	lmo1275	16803315	topA	DNA topoisomerase I [Listeria monocytoge...	692	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2GAI	38.4%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05304 (show subtarget assignments)	1	cloned	No	Z1313	12514147	helD	DNA helicase IV [Escherichia coli O157:H...	715	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2IS1	14.3%	Escherichia coli	DNA metabolism: DNA replication, recombination, and repair

IDP05766 (show subtarget assignments)	1	expressed	No	S0723	30040469		putative helicase [Shigella flexneri 2a ...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2R6A	31.7%	Shigella flexneri	DNA metabolism: DNA replication, recombination, and repair

IDP05759 (show subtarget assignments)	1	cloned	No	lmo1759	16803799	pcrA	ATP-dependent DNA helicase [Listeria mon...	733	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1PJR	65.1%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05706 (show subtarget assignments)	1	purified	No	lmo2756	16804793	topB	DNA topoisomerase III [Listeria monocyto...	717	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1D6M	28.6%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05649 (show subtarget assignments)	1	expressed	No	Cj0464	6967934	recG	zinc protease-like protein [Campylobacte...	607	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GM5	28.8%	Campylobacter jejuni	DNA metabolism: DNA replication, recombination, and repair

IDP02261 (show subtarget assignments)	1	expressed	No	GBAA2516	47527804	fba-1	fructose-bisphosphate aldolase [Bacillus...	281	Essential; Drug target functions	Phase 3: June 2008	1RV8	41.2%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02251 (show subtarget assignments)	1	cloned	No	YPO1201	16121494		putative amino acid decarboxylase [Yersi...	768	Involved in virulence; Drug target functions	Phase 3: June 2008	2VYC	51.6%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02246 (show subtarget assignments)	1	expressed	No	FTT0649c	56707771	rnfB	Iron-sulfur cluster-binding protein [Fra...	209	Drug Target	Phase 3: June 2008	1GT8	12.9%	Francisella tularensis	Energy metabolism	Electron transport

IDP02229 (show subtarget assignments)	1	cloned	No	YPO1302	16121584	psaF	hypothetical protein YPO1302 [Yersinia p...	162	Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Energy metabolism	Photosynthesis

IDP02226 (show subtarget assignments)	1	crystallized	No	GBAA0164	47525422	yqjI	6-phosphogluconate dehydrogenase [Bacill...	469	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2W8Z	72.3%	Bacillus anthracis	Energy metabolism	Pentose phosphate pathway

IDP02224 (show subtarget assignments)	1	cloned	No	YPO0616	16120942		putative glycosyl hydrolase [Yersinia pe...	727	Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...	Phase 3: June 2008	2X40	26.5%	Yersinia pestis	Energy metabolism	Sugars

IDP02220 (show subtarget assignments)	1	cloned	No	YPO2221	16122450	acnA	aconitate hydratase [Yersinia pestis CO9...	890	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3SN2	52.2%	Yersinia pestis	Energy metabolism	TCA cycle

IDP02210 (show subtarget assignments)	1	cloned	No	FTT0980	56708072		hypothetical protein FTT0980 [Francisell...	413	Conserved; Drug target functions	Phase 3: June 2008	1FC4	26.4%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP02194 (show subtarget assignments)	1	expressed	No	FTT0075	56707254	sdhB	succinate dehydrogenase iron-sulfur subu...	233	Conserved; Drug target functions	Phase 3: June 2008	1NEK	66.7%	Francisella tularensis	Energy metabolism	TCA cycle

IDP01082 (show subtarget assignments)	1	expressed	No	STM4279	16767529	nrfC	putative formate-dependent nitrite reduc...	223	Essential Gene	Phase 2: March 2008	2VPW	35.9%	Salmonella enterica	Energy metabolism	Electron transport

IDP02192 (show subtarget assignments)	1	soluble	No	YPO0348	16120683	aspA	aspartate ammonia-lyase [Yersinia pestis...	478	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1JSW	89.3%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP00569 (show subtarget assignments)	1	purified	No	YPO4016	16124139	hutH	histidine ammonia-lyase	510	Drug Target Function	Phase 2: March 2008	1GK2	77.5%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02190 (show subtarget assignments)	1	expressed	No	YPO0360	16120695	frdA	fumarate reductase flavoprotein subunit ...	607	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1KF6	85.2%	Yersinia pestis	Energy metabolism	Anaerobic

IDP02187 (show subtarget assignments)	1	purified	No	FTT0504c	56707643	sucC	succinyl-CoA synthetase subunit beta [Fr...	387	Conserved; Drug target functions	Phase 3: June 2008	1CQI	62.8%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02185 (show subtarget assignments)	1	selected	No	FTT0408	56707557	gcvH	glycine cleavage system H protein [Franc...	127	Drug Target	Phase 3: June 2008	3A7A	59.8%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP02182 (show subtarget assignments)	1	cloned	No	FTT0065	56707244	atpC	F0F1 ATP synthase subunit epsilon [Franc...	145	Conserved; Drug target functions	Phase 3: June 2008	2QE7	33.1%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP00567 (show subtarget assignments)	0	work_stopped	No	YPO1113	16121413	kgd	alpha-ketoglutarate decarboxylase	935	Virulence Associated Factor	Phase 2: March 2008	2JGD	87.8%	Yersinia pestis	Energy metabolism	TCA cycle

IDP02178 (show subtarget assignments)	1	soluble	No	FTT0032	56707212	nuoB	NADH dehydrogenase subunit B [Francisell...	158	Drug Target	Phase 3: June 2008	2FUG	53.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP02177 (show subtarget assignments)	1	soluble	No	FTT0063	56707242	atpG	F0F1 ATP synthase subunit gamma [Francis...	298	Conserved; Drug target functions	Phase 3: June 2008	3OAA	49.7%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP01073 (show subtarget assignments)	1	purified	No	STM4044	16767310		putative alcohol dehydrogenase	382	Conserved Gene / Pathway	Phase 2: March 2008	1RRM	42.6%	Salmonella enterica	Energy metabolism	Fermentation

IDP04722 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1357	115347116	ltaA	L-allo-threonine aldolase [Yersinia pest...	339	conserved gene; putative drug target function;	Phase 4: April 2009	1LW4	46.5%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02172 (show subtarget assignments)	1	cloned	No	YPO0893	16121198	fldB	flavodoxin FldB [Yersinia pestis CO92]	172	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1FLV	46.5%	Yersinia pestis	Energy metabolism	Electron transport

IDP02169 (show subtarget assignments)	1	soluble	No	FTT0306	56707459	fumC	fumarate hydratase [Francisella tularens...	463	Conserved; Drug target functions	Phase 3: June 2008	3E04	55.3%	Francisella tularensis	Energy metabolism	TCA cycle

IDP04721 (show subtarget assignments)	1	expressed	No	YPO1289	115347051		conserved hypothetical protein [Yersinia...	380	conserved gene; putative drug target function;	Phase 4: April 2009	2Q18	16.8%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP00562 (show subtarget assignments)	1	purified	No	YPO2908	16123099	hmp	nitric oxide dioxygenase	396	Virulence Associated Factor	Phase 2: March 2008	1GVH	63.1%	Yersinia pestis	Energy metabolism	Electron transport

IDP02152 (show subtarget assignments)	1	soluble	No	FTT0955c	56708049	gor	glutathione reductase [Francisella tular...	453	Conserved; Drug target functions	Phase 3: June 2008	1GER	49.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP02145 (show subtarget assignments)	1	cloned	No	YPO1301	16121583	psaE	putative regulatory protein [Yersinia pe...	214	Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Energy metabolism	Photosynthesis

IDP00556 (show subtarget assignments)	1	cloned	No	YPO2686	16122891	pgm	phosphoglucomutase	547	Drug Target Function	Phase 2: March 2008	2FUV	82.4%	Yersinia pestis	Energy metabolism	Sugars

IDP00553 (show subtarget assignments)	1	expressed	No	YPO3939	16124067	glgA	glycogen synthase	476	Drug Target Function	Phase 2: March 2008	2QZS	71.4%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02125 (show subtarget assignments)	1	cloned	No	STM4453	16767699	treC	trehalose-6-phosphate hydrolase [Salmone...	550	Conserved; Drug target functions	Phase 3: June 2008	1UOK	44.7%	Salmonella enterica	Energy metabolism	Other

IDP02119 (show subtarget assignments)	1	in_pdb 3KWM	No	FTT1208	56708271	rpiA	ribose-5-phosphate isomerase A [Francise...	224	Conserved; Drug target functions	Phase 3: June 2008	3KWM	100%	Francisella tularensis	Energy metabolism	Pentose phosphate pathway

IDP02118 (show subtarget assignments)	1	cloned	No	STM4388	16767634	sgaE	L-ribulose-5-phosphate 4-epimerase [Salm...	228	Conserved; Drug target functions	Phase 3: June 2008	1JDI	60%	Salmonella enterica	Energy metabolism	Sugars

IDP00119 (show subtarget assignments)	1	purified	No	NT01ST0753	16763999	citE	citrate lyase beta chain	302	Essential	Phase 1: October 2007	1SGJ	32.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP01042 (show subtarget assignments)	1	in_crystallization_trials	No	STM2973	16766278	fucO	L-1,2-propanediol oxidoreductase	382	Conserved Gene / Pathway	Phase 2: March 2008	1RRM	91.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP02111 (show subtarget assignments)	1	in_crystallization_trials	No	STM3694	16766979	lldD	L-lactate dehydrogenase [Salmonella typh...	396	Conserved; Drug target functions	Phase 3: June 2008	1AL7	32.6%	Salmonella enterica	Energy metabolism	Aerobic

IDP02108 (show subtarget assignments)	1	in_crystallization_trials	No	STM3680	16766965	aldB	aldehyde dehydrogenase B [Salmonella typ...	512	Conserved; Drug target functions	Phase 3: June 2008	1NZW	40.6%	Salmonella enterica	Energy metabolism	Other

IDP01041 (show subtarget assignments)	1	purified	No	STM2971	16766276	sdaB	L-serine dehydratase/L-threonine deamina...	455	Conserved Gene / Pathway	Phase 2: March 2008	2IQQ	16%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP00546 (show subtarget assignments)	1	expressed	No	YPO0359	16120694	frdB	fumarate reductase iron-sulfur subunit	244	Virulence Associated Factor	Phase 2: March 2008	1KF6	84.8%	Yersinia pestis	Energy metabolism	Anaerobic

IDP02096 (show subtarget assignments)	1	cloned	No	YPO0178	16120519	prk	phosphoribulokinase 1 [Yersinia pestis C...	289	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1A7J	49.5%	Yersinia pestis	Energy metabolism	Photosynthesis

IDP02095 (show subtarget assignments)	1	in_pdb 3TNO 3TK7 3TE9 3TKF 3UPB 4E0C 3IGX	No	FTT1093c	56708176	talA	transaldolase B [Francisella tularensis ...	321	Conserved; Drug target functions	Phase 3: June 2008	3IGX	100%	Francisella tularensis	Energy metabolism	Pentose phosphate pathway

IDP02094 (show subtarget assignments)	1	cloned	No	STM3598	16766884		putative L-asparaginase [Salmonella typh...	347	Conserved; Drug target functions	Phase 3: June 2008	1ZCF	68.9%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP02091 (show subtarget assignments)	1	expressed	No	STM3515	16766803	malT	transcriptional regulator MalT [Salmonel...	901	Conserved; Drug target functions	Phase 3: June 2008	1HZ4	36.6%	Salmonella enterica	Energy metabolism	Other

IDP00543 (show subtarget assignments)	1	purified	No	YPO4057	16124173	fdoH	formate dehydrogenase-O, iron-sulfur sub...	323	Conserved Gene / Pathway	Phase 2: March 2008	1KQF	70.9%	Yersinia pestis	Energy metabolism	Anaerobic

IDP02084 (show subtarget assignments)	1	in_crystallization_trials	No	Cj0639c	15791999	adk	adenylate kinase [Campylobacter jejuni s...	192	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1P4S	34.9%	Campylobacter jejuni	Energy metabolism	Electron transport

IDP02082 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0080	56707259	tpiA	triosephosphate isomerase [Francisella t...	253	Conserved; Drug target functions	Phase 3: June 2008	1TMH	42.7%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00734 (show subtarget assignments)	1	purified	No	SACOL0841	57284303	pgm	phosphoglyceromutase	505	Drug Target Function	Phase 2: March 2008	1EJJ	62%	Staphylococcus aureus	Energy metabolism	Glycolysis/gluconeogenesis

IDP02074 (show subtarget assignments)	1	cloned	No	STM3149	16766449	hybA	hydrogenase 2 protein HybA [Salmonella t...	328	Conserved; Drug target functions	Phase 3: June 2008	1KQF	29.3%	Salmonella enterica	Energy metabolism	Anaerobic

IDP02072 (show subtarget assignments)	1	soluble	No	FTT0554	56707684		hypothetical protein FTT0554 [Francisell...	90	Drug Target	Phase 3: June 2008	4ADZ	35.6%	Francisella tularensis	Energy metabolism	Electron transport

IDP02065 (show subtarget assignments)	1	in_pdb 3IAC	No	STM3137	16766437		glucuronate isomerase [Salmonella typhim...	470	Conserved; Drug target functions	Phase 3: June 2008	3IAC	100%	Salmonella enterica	Energy metabolism	Sugars

IDP02041 (show subtarget assignments)	1	in_crystallization_trials	No	STM3051	16766352	bglA	6-phospho-beta-glucosidase A [Salmonella...	477	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	2XHY	95.4%	Salmonella enterica	Energy metabolism	Other

IDP01006 (show subtarget assignments)	1	soluble	No	STM2529	16765849		putative anaerobic dimethylsulfoxide red...	209	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	31.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP02038 (show subtarget assignments)	1	in_crystallization_trials	No	lmo2475	16804513		hypothetical protein lmo2475 [Listeria m...	576	Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...	Phase 3: June 2008	2Z0F	29.3%	Listeria monocytogenes	Energy metabolism	Sugars

IDP02023 (show subtarget assignments)	1	soluble	No	STM3661	16766946	xylA	xylose isomerase [Salmonella typhimurium...	440	Conserved; Drug target functions	Phase 3: June 2008	1A0D	51.6%	Salmonella enterica	Energy metabolism	Sugars

IDP02018 (show subtarget assignments)	1	expressed	No	STM2530	16765850		putative anaerobic dimethylsulfoxide red...	801	Conserved; Drug target functions	Phase 3: June 2008	1DMR	30.1%	Salmonella enterica	Energy metabolism	Anaerobic

IDP02014 (show subtarget assignments)	1	soluble	No	STM2341	16765668		putative transketolase [Salmonella typhi...	276	Conserved; Drug target functions	Phase 3: June 2008	2E6K	33%	Salmonella enterica	Energy metabolism	Pentose phosphate pathway

IDP02011 (show subtarget assignments)	1	cloned	No	STM2340	16765667		putative transketolase [Salmonella typhi...	317	Conserved; Drug target functions	Phase 3: June 2008	3MOS	32.1%	Salmonella enterica	Energy metabolism	Pentose phosphate pathway

IDP02007 (show subtarget assignments)	1	in_crystallization_trials	No	STM2330	16765657	lrhA	NADH dehydrogenase transcriptional repre...	312	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3ONM	38.8%	Salmonella enterica	Energy metabolism	Aerobic

IDP02006 (show subtarget assignments)	1	expressed	No	STM2285	16765612	glpB	anaerobic glycerol-3-phosphate dehydroge...	419	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Energy metabolism	Anaerobic

IDP02003 (show subtarget assignments)	1	cloned	No	YPO0190	16120529		glutathione-regulated potassium-efflux s...	183	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	3EYW	38.3%	Yersinia pestis	Energy metabolism	Electron transport

IDP02000 (show subtarget assignments)	1	cloned	No	YPO0008	16120361	rbsK	ribokinase [Yersinia pestis CO92]	308	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1GQT	70.5%	Yersinia pestis	Energy metabolism	Pentose phosphate pathway

IDP00983 (show subtarget assignments)	1	cloned	No	STM2064	16765394	phsB	thiosulfate reductase electron transport...	192	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	37%	Salmonella enterica	Energy metabolism	Electron transport

IDP01996 (show subtarget assignments)	1	in_crystallization_trials	No	STM3136	16766436		putative D-mannonate oxidoreductase [Sal...	490	Conserved; Drug target functions	Phase 3: June 2008	1LJ8	40.6%	Salmonella enterica	Energy metabolism	Other

IDP01992 (show subtarget assignments)	1	expressed	No	STM3822	16767107	torA	trimethylamine N-oxide reductase subunit...	850	Conserved; Drug target functions	Phase 3: June 2008	1TMO	50.5%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01989 (show subtarget assignments)	1	purified	No	STM2646	16765966	yfiD	autonomous glycyl radical cofactor GrcA ...	127	Conserved; Drug target functions	Phase 3: June 2008	1CM5	38.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP00981 (show subtarget assignments)	1	in_crystallization_trials	No	STM2052	16765382	pduQ	propanol dehydrogenase	370	Conserved Gene / Pathway	Phase 2: March 2008	3OWO	35.3%	Salmonella enterica	Energy metabolism	Fermentation

IDP01987 (show subtarget assignments)	1	soluble	No	YPO0155	16120498	rpe	ribulose-phosphate 3-epimerase [Yersinia...	225	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3INP	63.1%	Yersinia pestis	Energy metabolism	Pentose phosphate pathway

IDP01986 (show subtarget assignments)	1	soluble	No	YPO0138	16120481	pckA	phosphoenolpyruvate carboxykinase [Yersi...	539	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1AQ2	87.2%	Yersinia pestis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01980 (show subtarget assignments)	0	work_stopped	No	STM3054	16766355	gcvH	glycine cleavage system protein H [Salmo...	129	Conserved; Drug target functions	Phase 3: June 2008	3A8I	98.5%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP01979 (show subtarget assignments)	1	purified	No	STM3458	16766747	yheR	glutathione-regulated potassium-efflux s...	183	Conserved; Drug target functions	Phase 3: June 2008	3EYW	37.2%	Salmonella enterica	Energy metabolism	Electron transport

IDP01976 (show subtarget assignments)	1	in_pdb 3K96	Yes	CBU_1518	29542077	gpsA	glycerol-3-phosphate dehydrogenase (NAD+...	332	Conserved; Drug target functions	Phase 3: June 2008	3K96	100%	Coxiella burnetii	Energy metabolism	Other

IDP00110 (show subtarget assignments)	1	purified	No	NT01SF4145	30043548	glgC	glucose-1-phosphate adenylyltransferase ...	431	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3BRK	55.2%	Shigella flexneri	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02704
(show subtarget assignments)

1

soluble

No

lmo0007

16802055

gyrA

DNA gyrase subunit A [Listeria monocytog...

842

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

2XCO

40.4%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP00684
(show subtarget assignments)

1

cloned

No

SACOL1926

57286273

mutY

A/G-specific adenine glycosylase

345

Drug Target Function

Phase 2: March 2008

3FSP

45.8%

Staphylococcus aureus

DNA metabolism

DNA replication, recombination, and repair

IDP02606
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0006

16802054

gyrB

DNA gyrase subunit B [Listeria monocytog...

646

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

1EI1

31.4%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP00676
(show subtarget assignments)

1

expressed

No

SACOL1492

57284593

nth

endonuclease III

219

Drug Target Function

Phase 2: March 2008

1ORN

62.1%

Staphylococcus aureus

DNA metabolism

DNA replication, recombination, and repair

IDP02504
(show subtarget assignments)

1

purified

No

FTT1578c

56708604

ung

uracil-DNA glycosylase [Francisella tula...

220

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1EUG

58.6%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP02481
(show subtarget assignments)

1

cloned

No

Cj1139c

15792464

putative galactosyltransferase [Campylob...

303

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3BCV

24.1%

Campylobacter jejuni

DNA metabolism

DNA replication, recombination, and repair

IDP02479
(show subtarget assignments)

1

cloned

No

lmo1287

16803327

parC

DNA topoisomerase IV subunit A [Listeria...

819

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

2INR

41.8%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP02446
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0287

16802333

hypothetical protein lmo0287 [Listeria m...

237

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2OQR

48.1%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP05235
(show subtarget assignments)

1

cloned

No

lmo1532

16803572

ruvB

Holliday junction DNA helicase B [Lister...

335

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3PFI

55.2%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05236
(show subtarget assignments)

1

crystallized

No

lmo1533

16803573

ruvA

hypothetical protein lmo1533 [Listeria m...

201

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1IXR

34.8%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05233
(show subtarget assignments)

1

cloned

No

lmo1455

16803495

dnaG

DNA primase [Listeria monocytogenes EGD-...

626

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2AU3

21.7%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05229
(show subtarget assignments)

1

cloned

No

lmo1286

16803326

parE

DNA topoisomerase IV subunit B [Listeria...

655

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1EI1

29.8%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05220
(show subtarget assignments)

1

cloned

No

Cj1101

6968529

-

putative integral membrane protein [Camp...

670

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1PJR

36.6%

Campylobacter jejuni

DNA metabolism: DNA replication, recombination, and repair

IDP05559
(show subtarget assignments)

1

soluble

No

lmo1811

16803851

-

hypothetical protein lmo1811 [Listeria m...

697

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GM5

40.3%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05073
(show subtarget assignments)

1

expressed

No

Cj0562

6968026

dnaB

gamma-glutamyl phosphate reductase [Camp...

439

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2VYE

37.1%

Campylobacter jejuni

DNA metabolism: DNA replication, recombination, and repair

IDP05546
(show subtarget assignments)

1

cloned

No

lmo0054

16802102

dnaC

replicative DNA helicase [Listeria monoc...

450

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 5: 2010

2R6A

77.1%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05075
(show subtarget assignments)

1

cloned

No

lmo0466

16802510

-

hypothetical protein lmo0466 [Listeria m...

576

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05084
(show subtarget assignments)

1

in_crystallization_trials

No

Z4803

12518085

putative ATP-dependent DNA helicase (tog...

202

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1OYW

33.7%

Escherichia coli

DNA metabolism: DNA replication, recombination, and repair

IDP05573
(show subtarget assignments)

1

selected

No

BAS4798

49187788

-

cell surface protein, anchor [Bacillus a...

2025

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

DNA metabolism: DNA replication, recombination, and repair

IDP91277
(show subtarget assignments)

8

soluble

No

NT05BA4403

49181145

conserved hypothetical protein [Bacillus...

336

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1JQJ

17.3%

Bacillus anthracis

DNA metabolism: DNA replication, recombination, and repair

IDP91271
(show subtarget assignments)

8

expressed

No

NT05BA3690

49180451

prophage LambdaBa01, positive control fa...

167

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Bacillus anthracis

DNA metabolism: DNA replication, recombination, and repair

IDP91261
(show subtarget assignments)

8

soluble

No

NT05BA0041

49176992

DNA polymerase III, delta prime subunit ...

327

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1A5T

20.2%

Bacillus anthracis

DNA metabolism: DNA replication, recombination, and repair

IDP05336
(show subtarget assignments)

1

soluble

No

Cj0799c

6968240

ruvA

hypothetical protein Cj0794 [Campylobact...

183

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1IXR

32.5%

Campylobacter jejuni

DNA metabolism: DNA replication, recombination, and repair

IDP05323
(show subtarget assignments)

1

cloned

No

lmo1275

16803315

topA

DNA topoisomerase I [Listeria monocytoge...

692

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2GAI

38.4%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05304
(show subtarget assignments)

1

cloned

No

Z1313

12514147

helD

DNA helicase IV [Escherichia coli O157:H...

715

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2IS1

14.3%

Escherichia coli

DNA metabolism: DNA replication, recombination, and repair

IDP05766
(show subtarget assignments)

1

expressed

No

S0723

30040469

putative helicase [Shigella flexneri 2a ...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2R6A

31.7%

Shigella flexneri

DNA metabolism: DNA replication, recombination, and repair

IDP05759
(show subtarget assignments)

1

cloned

No

lmo1759

16803799

pcrA

ATP-dependent DNA helicase [Listeria mon...

733

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1PJR

65.1%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05706
(show subtarget assignments)

1

purified

No

lmo2756

16804793

topB

DNA topoisomerase III [Listeria monocyto...

717

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1D6M

28.6%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05649
(show subtarget assignments)

1

expressed

No

Cj0464

6967934

recG

zinc protease-like protein [Campylobacte...

607

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GM5

28.8%

Campylobacter jejuni

DNA metabolism: DNA replication, recombination, and repair

IDP02261
(show subtarget assignments)

1

expressed

No

GBAA2516

47527804

fba-1

fructose-bisphosphate aldolase [Bacillus...

281

Essential; Drug target functions

Phase 3: June 2008

1RV8

41.2%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02251
(show subtarget assignments)

1

cloned

No

YPO1201

16121494

putative amino acid decarboxylase [Yersi...

768

Involved in virulence; Drug target functions

Phase 3: June 2008

2VYC

51.6%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02246
(show subtarget assignments)

1

expressed

No

FTT0649c

56707771

rnfB

Iron-sulfur cluster-binding protein [Fra...

209

Drug Target

Phase 3: June 2008

1GT8

12.9%

Francisella tularensis

Energy metabolism

Electron transport

IDP02229
(show subtarget assignments)

1

cloned

No

YPO1302

16121584

psaF

hypothetical protein YPO1302 [Yersinia p...

162

Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Energy metabolism

Photosynthesis

IDP02226
(show subtarget assignments)

1

crystallized

No

GBAA0164

47525422

yqjI

6-phosphogluconate dehydrogenase [Bacill...

469

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2W8Z

72.3%

Bacillus anthracis

Energy metabolism

Pentose phosphate pathway

IDP02224
(show subtarget assignments)

1

cloned

No

YPO0616

16120942

putative glycosyl hydrolase [Yersinia pe...

727

Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...

Phase 3: June 2008

2X40

26.5%

Yersinia pestis

Energy metabolism

Sugars

IDP02220
(show subtarget assignments)

1

cloned

No

YPO2221

16122450

acnA

aconitate hydratase [Yersinia pestis CO9...

890

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3SN2

52.2%

Yersinia pestis

Energy metabolism

TCA cycle

IDP02210
(show subtarget assignments)

1

cloned

No

FTT0980

56708072

hypothetical protein FTT0980 [Francisell...

413

Conserved; Drug target functions

Phase 3: June 2008

1FC4

26.4%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP02194
(show subtarget assignments)

1

expressed

No

FTT0075

56707254

sdhB

succinate dehydrogenase iron-sulfur subu...

233

Conserved; Drug target functions

Phase 3: June 2008

1NEK

66.7%

Francisella tularensis

Energy metabolism

TCA cycle

IDP01082
(show subtarget assignments)

1

expressed

No

STM4279

16767529

nrfC

putative formate-dependent nitrite reduc...

223

Essential Gene

Phase 2: March 2008

2VPW

35.9%

Salmonella enterica

Energy metabolism

Electron transport

IDP02192
(show subtarget assignments)

1

soluble

No

YPO0348

16120683

aspA

aspartate ammonia-lyase [Yersinia pestis...

478

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1JSW

89.3%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP00569
(show subtarget assignments)

1

purified

No

YPO4016

16124139

hutH

histidine ammonia-lyase

510

Drug Target Function

Phase 2: March 2008

1GK2

77.5%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02190
(show subtarget assignments)

1

expressed

No

YPO0360

16120695

frdA

fumarate reductase flavoprotein subunit ...

607

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1KF6

85.2%

Yersinia pestis

Energy metabolism

Anaerobic

IDP02187
(show subtarget assignments)

1

purified

No

FTT0504c

56707643

sucC

succinyl-CoA synthetase subunit beta [Fr...

387

Conserved; Drug target functions

Phase 3: June 2008

1CQI

62.8%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02185
(show subtarget assignments)

1

selected

No

FTT0408

56707557

gcvH

glycine cleavage system H protein [Franc...

127

Drug Target

Phase 3: June 2008

3A7A

59.8%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP02182
(show subtarget assignments)

1

cloned

No

FTT0065

56707244

atpC

F0F1 ATP synthase subunit epsilon [Franc...

145

Conserved; Drug target functions

Phase 3: June 2008

2QE7

33.1%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP00567
(show subtarget assignments)

0

work_stopped

No

YPO1113

16121413

kgd

alpha-ketoglutarate decarboxylase

935

Virulence Associated Factor

Phase 2: March 2008

2JGD

87.8%

Yersinia pestis

Energy metabolism

TCA cycle

IDP02178
(show subtarget assignments)

1

soluble

No

FTT0032

56707212

nuoB

NADH dehydrogenase subunit B [Francisell...

158

Drug Target

Phase 3: June 2008

2FUG

53.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP02177
(show subtarget assignments)

1

soluble

No

FTT0063

56707242

atpG

F0F1 ATP synthase subunit gamma [Francis...

298

Conserved; Drug target functions

Phase 3: June 2008

3OAA

49.7%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP01073
(show subtarget assignments)

1

purified

No

STM4044

16767310

putative alcohol dehydrogenase

382

Conserved Gene / Pathway

Phase 2: March 2008

1RRM

42.6%

Salmonella enterica

Energy metabolism

Fermentation

IDP04722
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1357

115347116

ltaA

L-allo-threonine aldolase [Yersinia pest...

339

conserved gene; putative drug target function;

Phase 4: April 2009

1LW4

46.5%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02172
(show subtarget assignments)

1

cloned

No

YPO0893

16121198

fldB

flavodoxin FldB [Yersinia pestis CO92]

172

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1FLV

46.5%

Yersinia pestis

Energy metabolism

Electron transport

IDP02169
(show subtarget assignments)

1

soluble

No

FTT0306

56707459

fumC

fumarate hydratase [Francisella tularens...

463

Conserved; Drug target functions

Phase 3: June 2008

3E04

55.3%

Francisella tularensis

Energy metabolism

TCA cycle

IDP04721
(show subtarget assignments)

1

expressed

No

YPO1289

115347051

conserved hypothetical protein [Yersinia...

380

conserved gene; putative drug target function;

Phase 4: April 2009

2Q18

16.8%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP00562
(show subtarget assignments)

1

purified

No

YPO2908

16123099

hmp

nitric oxide dioxygenase

396

Virulence Associated Factor

Phase 2: March 2008

1GVH

63.1%

Yersinia pestis

Energy metabolism

Electron transport

IDP02152
(show subtarget assignments)

1

soluble

No

FTT0955c

56708049

gor

glutathione reductase [Francisella tular...

453

Conserved; Drug target functions

Phase 3: June 2008

1GER

49.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP02145
(show subtarget assignments)

1

cloned

No

YPO1301

16121583

psaE

putative regulatory protein [Yersinia pe...

214

Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Energy metabolism

Photosynthesis

IDP00556
(show subtarget assignments)

1

cloned

No

YPO2686

16122891

pgm

phosphoglucomutase

547

Drug Target Function

Phase 2: March 2008

2FUV

82.4%

Yersinia pestis

Energy metabolism

Sugars

IDP00553
(show subtarget assignments)

1

expressed

No

YPO3939

16124067

glgA

glycogen synthase

476

Drug Target Function

Phase 2: March 2008

2QZS

71.4%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02125
(show subtarget assignments)

1

cloned

No

STM4453

16767699

treC

trehalose-6-phosphate hydrolase [Salmone...

550

Conserved; Drug target functions

Phase 3: June 2008

1UOK

44.7%

Salmonella enterica

Energy metabolism

Other

IDP02119
(show subtarget assignments)

1

in_pdb
3KWM

No

FTT1208

56708271

rpiA

ribose-5-phosphate isomerase A [Francise...

224

Conserved; Drug target functions

Phase 3: June 2008

3KWM

100%

Francisella tularensis

Energy metabolism

Pentose phosphate pathway

IDP02118
(show subtarget assignments)

1

cloned

No

STM4388

16767634

sgaE

L-ribulose-5-phosphate 4-epimerase [Salm...

228

Conserved; Drug target functions

Phase 3: June 2008

1JDI

60%

Salmonella enterica

Energy metabolism

Sugars

IDP00119
(show subtarget assignments)

1

purified

No

NT01ST0753

16763999

citE

citrate lyase beta chain

302

Essential

Phase 1: October 2007

1SGJ

32.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP01042
(show subtarget assignments)

1

in_crystallization_trials

No

STM2973

16766278

fucO

L-1,2-propanediol oxidoreductase

382

Conserved Gene / Pathway

Phase 2: March 2008

1RRM

91.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP02111
(show subtarget assignments)

1

in_crystallization_trials

No

STM3694

16766979

lldD

L-lactate dehydrogenase [Salmonella typh...

396

Conserved; Drug target functions

Phase 3: June 2008

1AL7

32.6%

Salmonella enterica

Energy metabolism

Aerobic

IDP02108
(show subtarget assignments)

1

in_crystallization_trials

No

STM3680

16766965

aldB

aldehyde dehydrogenase B [Salmonella typ...

512

Conserved; Drug target functions

Phase 3: June 2008

1NZW

40.6%

Salmonella enterica

Energy metabolism

Other

IDP01041
(show subtarget assignments)

1

purified

No

STM2971

16766276

sdaB

L-serine dehydratase/L-threonine deamina...

455

Conserved Gene / Pathway

Phase 2: March 2008

2IQQ

16%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP00546
(show subtarget assignments)

1

expressed

No

YPO0359

16120694

frdB

fumarate reductase iron-sulfur subunit

244

Virulence Associated Factor

Phase 2: March 2008

1KF6

84.8%

Yersinia pestis

Energy metabolism

Anaerobic

IDP02096
(show subtarget assignments)

1

cloned

No

YPO0178

16120519

prk

phosphoribulokinase 1 [Yersinia pestis C...

289

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1A7J

49.5%

Yersinia pestis

Energy metabolism

Photosynthesis

IDP02095
(show subtarget assignments)

1

in_pdb
3TNO
3TK7
3TE9
3TKF
3UPB
4E0C
3IGX

No

FTT1093c

56708176

talA

transaldolase B [Francisella tularensis ...

321

Conserved; Drug target functions

Phase 3: June 2008

3IGX

100%

Francisella tularensis

Energy metabolism

Pentose phosphate pathway

IDP02094
(show subtarget assignments)

1

cloned

No

STM3598

16766884

putative L-asparaginase [Salmonella typh...

347

Conserved; Drug target functions

Phase 3: June 2008

1ZCF

68.9%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP02091
(show subtarget assignments)

1

expressed

No

STM3515

16766803

malT

transcriptional regulator MalT [Salmonel...

901

Conserved; Drug target functions

Phase 3: June 2008

1HZ4

36.6%

Salmonella enterica

Energy metabolism

Other

IDP00543
(show subtarget assignments)

1

purified

No

YPO4057

16124173

fdoH

formate dehydrogenase-O, iron-sulfur sub...

323

Conserved Gene / Pathway

Phase 2: March 2008

1KQF

70.9%

Yersinia pestis

Energy metabolism

Anaerobic

IDP02084
(show subtarget assignments)

1

in_crystallization_trials

No

Cj0639c

15791999

adk

adenylate kinase [Campylobacter jejuni s...

192

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1P4S

34.9%

Campylobacter jejuni

Energy metabolism

Electron transport

IDP02082
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0080

56707259

tpiA

triosephosphate isomerase [Francisella t...

253

Conserved; Drug target functions

Phase 3: June 2008

1TMH

42.7%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00734
(show subtarget assignments)

1

purified

No

SACOL0841

57284303

pgm

phosphoglyceromutase

505

Drug Target Function

Phase 2: March 2008

1EJJ

62%

Staphylococcus aureus

Energy metabolism

Glycolysis/gluconeogenesis

IDP02074
(show subtarget assignments)

1

cloned

No

STM3149

16766449

hybA

hydrogenase 2 protein HybA [Salmonella t...

328

Conserved; Drug target functions

Phase 3: June 2008

1KQF

29.3%

Salmonella enterica

Energy metabolism

Anaerobic

IDP02072
(show subtarget assignments)

1

soluble

No

FTT0554

56707684

hypothetical protein FTT0554 [Francisell...

90

Drug Target

Phase 3: June 2008

4ADZ

35.6%

Francisella tularensis

Energy metabolism

Electron transport

IDP02065
(show subtarget assignments)

1

in_pdb
3IAC

No

STM3137

16766437

glucuronate isomerase [Salmonella typhim...

470

Conserved; Drug target functions

Phase 3: June 2008

3IAC

100%

Salmonella enterica

Energy metabolism

Sugars

IDP02041
(show subtarget assignments)

1

in_crystallization_trials

No

STM3051

16766352

bglA

6-phospho-beta-glucosidase A [Salmonella...

477

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

2XHY

95.4%

Salmonella enterica

Energy metabolism

Other

IDP01006
(show subtarget assignments)

1

soluble

No

STM2529

16765849

putative anaerobic dimethylsulfoxide red...

209

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

31.6%

Salmonella enterica

Energy metabolism

Anaerobic

IDP02038
(show subtarget assignments)

1

in_crystallization_trials

No

lmo2475

16804513

hypothetical protein lmo2475 [Listeria m...

576

Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...

Phase 3: June 2008

2Z0F

29.3%

Listeria monocytogenes

Energy metabolism

Sugars

IDP02023
(show subtarget assignments)

1

soluble

No

STM3661

16766946

xylA

xylose isomerase [Salmonella typhimurium...

440

Conserved; Drug target functions

Phase 3: June 2008

1A0D

51.6%

Salmonella enterica

Energy metabolism

Sugars

IDP02018
(show subtarget assignments)

1

expressed

No

STM2530

16765850

putative anaerobic dimethylsulfoxide red...

801

Conserved; Drug target functions

Phase 3: June 2008

1DMR

30.1%

Salmonella enterica

Energy metabolism

Anaerobic

IDP02014
(show subtarget assignments)

1

soluble

No

STM2341

16765668

putative transketolase [Salmonella typhi...

276

Conserved; Drug target functions

Phase 3: June 2008

2E6K

33%

Salmonella enterica

Energy metabolism

Pentose phosphate pathway

IDP02011
(show subtarget assignments)

1

cloned

No

STM2340

16765667

putative transketolase [Salmonella typhi...

317

Conserved; Drug target functions

Phase 3: June 2008

3MOS

32.1%

Salmonella enterica

Energy metabolism

Pentose phosphate pathway

IDP02007
(show subtarget assignments)

1

in_crystallization_trials

No

STM2330

16765657

lrhA

NADH dehydrogenase transcriptional repre...

312

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3ONM

38.8%

Salmonella enterica

Energy metabolism

Aerobic

IDP02006
(show subtarget assignments)

1

expressed

No

STM2285

16765612

glpB

anaerobic glycerol-3-phosphate dehydroge...

419

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Energy metabolism

Anaerobic

IDP02003
(show subtarget assignments)

1

cloned

No

YPO0190

16120529

glutathione-regulated potassium-efflux s...

183

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

3EYW

38.3%

Yersinia pestis

Energy metabolism

Electron transport

IDP02000
(show subtarget assignments)

1

cloned

No

YPO0008

16120361

rbsK

ribokinase [Yersinia pestis CO92]

308

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1GQT

70.5%

Yersinia pestis

Energy metabolism

Pentose phosphate pathway

IDP00983
(show subtarget assignments)

1

cloned

No

STM2064

16765394

phsB

thiosulfate reductase electron transport...

192

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

37%

Salmonella enterica

Energy metabolism

Electron transport

IDP01996
(show subtarget assignments)

1

in_crystallization_trials

No

STM3136

16766436

putative D-mannonate oxidoreductase [Sal...

490

Conserved; Drug target functions

Phase 3: June 2008

1LJ8

40.6%

Salmonella enterica

Energy metabolism

Other

IDP01992
(show subtarget assignments)

1

expressed

No

STM3822

16767107

torA

trimethylamine N-oxide reductase subunit...

850

Conserved; Drug target functions

Phase 3: June 2008

1TMO

50.5%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01989
(show subtarget assignments)

1

purified

No

STM2646

16765966

yfiD

autonomous glycyl radical cofactor GrcA ...

127

Conserved; Drug target functions

Phase 3: June 2008

1CM5

38.6%

Salmonella enterica

Energy metabolism

Anaerobic

IDP00981
(show subtarget assignments)

1

in_crystallization_trials

No

STM2052

16765382

pduQ

propanol dehydrogenase

370

Conserved Gene / Pathway

Phase 2: March 2008

3OWO

35.3%

Salmonella enterica

Energy metabolism

Fermentation

IDP01987
(show subtarget assignments)

1

soluble

No

YPO0155

16120498

rpe

ribulose-phosphate 3-epimerase [Yersinia...

225

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3INP

63.1%

Yersinia pestis

Energy metabolism

Pentose phosphate pathway

IDP01986
(show subtarget assignments)

1

soluble

No

YPO0138

16120481

pckA

phosphoenolpyruvate carboxykinase [Yersi...

539

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1AQ2

87.2%

Yersinia pestis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01980
(show subtarget assignments)

0

work_stopped

No

STM3054

16766355

gcvH

glycine cleavage system protein H [Salmo...

129

Conserved; Drug target functions

Phase 3: June 2008

3A8I

98.5%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP01979
(show subtarget assignments)

1

purified

No

STM3458

16766747

yheR

glutathione-regulated potassium-efflux s...

183

Conserved; Drug target functions

Phase 3: June 2008

3EYW

37.2%

Salmonella enterica

Energy metabolism

Electron transport

IDP01976
(show subtarget assignments)

1

in_pdb
3K96

Yes

CBU_1518

29542077

gpsA

glycerol-3-phosphate dehydrogenase (NAD+...

332

Conserved; Drug target functions

Phase 3: June 2008

3K96

100%

Coxiella burnetii

Energy metabolism

Other

IDP00110
(show subtarget assignments)

1

purified

No

NT01SF4145

30043548

glgC

glucose-1-phosphate adenylyltransferase ...

431

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3BRK

55.2%

Shigella flexneri

Energy metabolism

Biosynthesis and degradation of polysaccharides

Targets