Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02830 (show subtarget assignments)	1	soluble	No	GBAA4861	47530155	pepQ-2	proline dipeptidase [Bacillus anthracis ...	365	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	1WY2	38.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02831 (show subtarget assignments)	1	crystallized	No	GBAA4686	47529986	maf	Maf-like protein [Bacillus anthracis str...	191	Conserved; Drug target functions	Phase 3: June 2008	1EX2	53.4%	Bacillus anthracis	Cellular processes	Cell division

IDP02832 (show subtarget assignments)	1	expressed	No	FTT1518	56708554	ogt	methylated-DNA--protein-cysteine methylt...	190	Conserved; Drug target functions	Phase 3: June 2008	1SFE	28.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy	Heme, porphyrin, and cobalaminOther,tRNA and rRNA base modification

IDP02833 (show subtarget assignments)	1	cloned	No	GBAA4561	47529857	aroE	shikimate 5-dehydrogenase [Bacillus anth...	308	Conserved; Drug target functions	Phase 3: June 2008	2EGG	49.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02834 (show subtarget assignments)	1	expressed	No	GBAA4975	47530273	moaC	molybdenum cofactor biosynthesis protein...	161	Conserved; Drug target functions	Phase 3: June 2008	2EEY	69.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP02835 (show subtarget assignments)	1	expressed	No	FTT0631	56707756	hflX	protease, GTP-binding subunit [Francisel...	435	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2QTF	22.8%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02836 (show subtarget assignments)	1	crystallized	No	GBAA4423	47529716	aroQ	3-dehydroquinate dehydratase [Bacillus a...	146	Conserved; Drug target functions	Phase 3: June 2008	1GQO	57.5%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP04002 (show subtarget assignments)	8	selected	No	CAC05806	12329075	ipgA	IpgA, similarities to IpgE, putative cha...	129	Shigella effector protein	Community Requests			Shigella flexneri

IDP04003 (show subtarget assignments)	1	cloned	No	BAS0126	49183160		50S ribosomal protein L18 [Bacillus anth...	120	Proposed to be essential proteins	Phase 4: April 2009	1OVY	75.8%	Bacillus anthracis

IDP04004 (show subtarget assignments)	1	cloned	No	CPF_1305	110799423	mtnN	5'-methylthioadenosine/S-adenosylhomocys...	266	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3EEI	34.6%	Clostridium perfringens	Central intermediary metabolism	Other

IDP04005 (show subtarget assignments)	1	purified	No	BAS4355	49187350		valyl-tRNA synthetase [Bacillus anthraci...	881	Proposed to be essential proteins	Phase 4: April 2009	1GAX	42.6%	Bacillus anthracis

IDP04006 (show subtarget assignments)	1	cloned	No	CPF_1351	110800739		putative lipoprotein [Clostridium perfri...	264	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04007 (show subtarget assignments)	1	expressed	No	VC1319	15641331		sensor histidine kinase [Vibrio cholerae...	440	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Vibrio cholerae	Regulatory functions	Other

IDP04008 (show subtarget assignments)	1	cloned	No	YPO0906	218928079	gcsH	glycine cleavage system protein H [Yersi...	128	conserved gene; putative drug target function;	Phase 4: April 2009	3A7A	75%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04009 (show subtarget assignments)	1	cloned	No	VC2277	15642275		xanthine-guanine phosphoribosyltransfera...	154	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A95	68.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP04010 (show subtarget assignments)	1	cloned	No	CPF_2393	110798628	minD	septum site-determining protein MinD [Cl...	265	conserved gene; putative drug target function;	Phase 4: April 2009	3Q9L	43.4%	Clostridium perfringens	Cellular processes	Cell division

IDP04011 (show subtarget assignments)	1	cloned	No	CPF_2475	110800353		stage II sporulation protein R [Clostrid...	209	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04012 (show subtarget assignments)	1	cloned	No	CPF_2355	110800506	virJ	sensor histidine kinase [Clostridium per...	482	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	15.4%	Clostridium perfringens	Cellular processes	Pathogenesis

IDP04013 (show subtarget assignments)	1	cloned	No	STM2913_1_498	16766219		putative permease [Salmonella typhimuriu...	498	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04014 (show subtarget assignments)	1	purified	No	YPO3173	115348814	thiI	thiamine biosynthesis protein [Yersinia ...	483	conserved gene; putative drug target function;	Phase 4: April 2009	2C5S	23.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04015 (show subtarget assignments)	1	purified	No	VC0395	15640422		UTP--glucose-1-phosphate uridylyltransfe...	291	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3JUJ	58.1%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides

IDP04016 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0834	110798754	arsC	arsenate reductase ArsC [Clostridium per...	132	conserved gene; putative drug target function;	Phase 4: April 2009	2L17	40.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04017 (show subtarget assignments)	1	cloned	No	CPF_1035	110799411		putative lipoprotein [Clostridium perfri...	309	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04018 (show subtarget assignments)	1	cloned	No	CPF_1860	110799668	msrB	methionine sulfoxide reductase B [Clostr...	147	conserved gene; putative drug target function;	Phase 4: April 2009	1XM0	64.6%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04019 (show subtarget assignments)	1	cloned	No	CPF_2080	110799586	spoIIIAH	stage III sporulation protein AH [Clostr...	165	conserved gene; putative drug target function;	Phase 4: April 2009	3TUF	24.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04020 (show subtarget assignments)	1	cloned	No	CPF_2112	110800515		cell division protein FtsQ [Clostridium ...	248	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Cell division

IDP04021 (show subtarget assignments)	1	expressed	No	BAS3695	49186694		30S ribosomal protein S16 [Bacillus anth...	90	Proposed to be essential proteins	Phase 4: April 2009	1EMW	42.2%	Bacillus anthracis

IDP04022 (show subtarget assignments)	1	cloned	No	BAS0095	49183129		preprotein translocase subunit SecE [Bac...	59	Proposed to be essential proteins	Phase 4: April 2009	3DIN	33.9%	Bacillus anthracis

IDP04023 (show subtarget assignments)	1	cloned	No	YPO0511a	115346321		hypothetical protein [Yersinia pestis CO...	121	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04024 (show subtarget assignments)	1	cloned	No	BAS5319	49188303		DNA-binding response regulator YycF [Bac...	235	Proposed to be essential proteins	Phase 4: April 2009	2OQR	47.7%	Bacillus anthracis

IDP04025 (show subtarget assignments)	1	expressed	No	YPCD1.36c	16082724	yscX	hypothetical protein YPCD1.36c [Yersinia...	122	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04026 (show subtarget assignments)	1	expressed	No	FTT0456c	56707598		hypothetical protein FTT_0456c [Francise...	97	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1YHD	39.2%	Francisella tularensis

IDP04027 (show subtarget assignments)	1	cloned	No	BAS4637	49187628		leucyl-tRNA synthetase [Bacillus anthrac...	802	Proposed to be essential proteins	Phase 4: April 2009	1H3N	45.9%	Bacillus anthracis

IDP04028 (show subtarget assignments)	1	purified	No	BAS0109	49183143		30S ribosomal protein S10 [Bacillus anth...	102	Proposed to be essential proteins	Phase 4: April 2009	1P6G	61.8%	Bacillus anthracis

IDP04029 (show subtarget assignments)	1	soluble	No	YPO0500	115346309		conserved hypothetical protein [Yersinia...	186	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04030 (show subtarget assignments)	1	cloned	No	YPO2532	115348229		hypothetical protein [Yersinia pestis CO...	70	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04031 (show subtarget assignments)	1	cloned	No	CBU_A0011	29648123		hypothetical protein CBUA0011 [Coxiella ...	56	drug target;	Phase 4: April 2009			Coxiella burnetii	Hypothetical proteins	Domain

IDP04032 (show subtarget assignments)	1	cloned	No	CPF_2081	110798910		stage III sporulation protein AG [Clostr...	201	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04033 (show subtarget assignments)	1	soluble	No	VC1950	15641952		biotin sulfoxide reductase [Vibrio chole...	815	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1E18	48.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04034 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0128	49183162		50S ribosomal protein L30 [Bacillus anth...	60	Proposed to be essential proteins	Phase 4: April 2009	1VS6	53.3%	Bacillus anthracis

IDP04035 (show subtarget assignments)	1	in_pdb 3P0R	Yes	BAS5262	49188247		azoreductase [Bacillus anthracis str. St...	208	Proposed to be essential proteins	Phase 4: April 2009	3P0R	100%	Bacillus anthracis

IDP04036 (show subtarget assignments)	1	cloned	No	CPF_1970	110800938	smc	chromosome segregation protein SMC [Clos...	1185	conserved gene; putative drug target function;	Phase 4: April 2009	3AUX	8.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04037 (show subtarget assignments)	1	in_pdb 3S52	No	YPO2082	115347800		putative fumarylacetoacetate hydrolase f...	218	putative drug target function;	Phase 4: April 2009	3S52	100%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04038 (show subtarget assignments)	1	expressed	No	YPCD1.65	5832485	YPCD1.65	putative transposase [Yersinia pestis CO...	102	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04039 (show subtarget assignments)	1	cloned	No	CPF_2446	110800060	spoIIID	stage III sporulation protein D [Clostri...	83	conserved gene; putative drug target function;	Phase 4: April 2009	2L0K	60.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04040 (show subtarget assignments)	1	cloned	No	CPF_1068	110800949	cotJC	spore coat protein CotJC [Clostridium pe...	188	conserved gene; putative drug target function;	Phase 4: April 2009	1JKU	34.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04041 (show subtarget assignments)	1	cloned	No	YPCD1.16c	5832438	YPCD1.16c	hypothetical protein YPCD1.16c [Yersinia...	107	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP04042 (show subtarget assignments)	1	cloned	No	CPF_0296	110798725		putative cell division ATP-binding prote...	228	conserved gene; putative drug target function;	Phase 4: April 2009	1F3O	40.6%	Clostridium perfringens	Cellular processes	Cell division

IDP04043 (show subtarget assignments)	1	soluble	No	VCA0565	15601324		sensor histidine kinase [Vibrio cholerae...	499	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BXD	6%	Vibrio cholerae	Regulatory functions	Other

IDP04044 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1530	56708564	fadB/acbP	fusion product of 3-hydroxacyl-CoA dehyd...	898	drug target; conserved gene;	Phase 4: April 2009	3K6J	11.7%	Francisella tularensis	Fatty acid and phospholipid metabolism	Degradation

IDP04045 (show subtarget assignments)	1	soluble	No	FTT1747	56708745		outer membrane protein [Francisella tula...	191	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Francisella tularensis

IDP04046 (show subtarget assignments)	1	cloned	No	YPCD1.78c	16082765	tap	repA translation protein [Yersinia pesti...	24	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04047 (show subtarget assignments)	1	cloned	No	YPCD1.92	5832507	YPCD1.92	hypothetical protein YPCD1.92 [Yersinia ...	109	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04048 (show subtarget assignments)	1	in_crystallization_trials	No	VC1112	15641125		biotin synthase [Vibrio cholerae O1 biov...	350	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1R30	69.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04049 (show subtarget assignments)	1	soluble	No	VC1132	15641145	hisG	ATP phosphoribosyltransferase [Vibrio ch...	304	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1H3D	65.8%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP04050 (show subtarget assignments)	1	purified	No	YPO1765	218928887	hpaF	5-carboxymethyl-2-hydroxymuconate delta-...	132	conserved gene; putative drug target function;	Phase 4: April 2009	1OTG	67.4%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04051 (show subtarget assignments)	1	expressed	No	YPO0511	115346320		hypothetical protein [Yersinia pestis CO...	205	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04052 (show subtarget assignments)	1	cloned	No	CPF_0049	110799596		putative lipoprotein [Clostridium perfri...	167	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04053 (show subtarget assignments)	1	cloned	No	CPF_2307	110801393	spoIIAA	anti-sigma F factor antagonist [Clostrid...	111	conserved gene; putative drug target function;	Phase 4: April 2009	1TH8	45%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04054 (show subtarget assignments)	1	soluble	No	YPO0508	115346317		hypothetical protein [Yersinia pestis CO...	190	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Other

IDP04055 (show subtarget assignments)	1	cloned	No	STM0301_1_836	16763684	safC	putative fimbrial usher [Salmonella typh...	836	Salmonella essential protein	Phase 4: April 2009	3RFZ	37%	Salmonella enterica

IDP04057 (show subtarget assignments)	1	purified	No	BAS0125	49183159		50S ribosomal protein L6 [Bacillus anthr...	179	Proposed to be essential proteins	Phase 4: April 2009	1C04	74.9%	Bacillus anthracis

IDP04058 (show subtarget assignments)	1	soluble	No	CPF_0556	110800185		ABC transporter, solute-binding protein ...	461	drug target; putative drug target function;	Phase 4: April 2009	1EU8	18.9%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04059 (show subtarget assignments)	1	expressed	No	VC1973	9656513		naphthoate synthase [Vibrio cholerae O1 ...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3H02	80.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04060 (show subtarget assignments)	8	selected	No	CAC05813	12329082	mxiI	MxiI, component of the Mxi-Spa secretion...	97	Shigella effector protein	Community Requests			Shigella flexneri

IDP04061 (show subtarget assignments)	1	cloned	No	YPCD1.07	5832430	YPCD1.07	hypothetical protein YPCD1.07 [Yersinia ...	98	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04062 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0637	9658051		oxygen-insensitive NAD(P)H nitroreductas...	217	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HZN	59.4%	Vibrio cholerae	Central intermediary metabolism	Other

IDP04063 (show subtarget assignments)	1	cloned	No	CPF_0514	110800714		putative lipoprotein [Clostridium perfri...	176	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04064 (show subtarget assignments)	1	expressed	No	BAS0127	49183161		30S ribosomal protein S5 [Bacillus anthr...	166	Proposed to be essential proteins	Phase 4: April 2009	1PKP	75.3%	Bacillus anthracis

IDP04065 (show subtarget assignments)	1	cloned	No	CPF_2985	110800289	yyaC	putative sporulation protein YyaC [Clost...	196	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04066 (show subtarget assignments)	8	selected	No	CAC05819	12329088	mxiE	MxiE, similarities to transcriptional ac...	210	Shigella effector protein	Community Requests			Shigella flexneri

IDP04067 (show subtarget assignments)	1	purified	No	BAS4417	49187412		thioredoxin [Bacillus anthracis str. Ste...	104	Proposed to be essential proteins	Phase 4: April 2009	2GZY	75%	Bacillus anthracis

IDP04068 (show subtarget assignments)	1	expressed	No	YPCD1.94n	40548799		hypothetical protein YPCD1.94n [Yersinia...	251	virulence factor;	Phase 4: April 2009	1A5V	15.1%	Yersinia pestis

IDP04069 (show subtarget assignments)	1	in_pdb 3R3T	Yes	BAS5327	49188311		30S ribosomal protein S6 [Bacillus anthr...	96	Proposed to be essential proteins	Phase 4: April 2009	3R3T	100%	Bacillus anthracis

IDP04070 (show subtarget assignments)	1	cloned	No	FTT0073	56707252	sdhD	succinate dehydrogenase hydrophobic memb...	122	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NEK	26.2%	Francisella tularensis

IDP04071 (show subtarget assignments)	1	cloned	No	BAS0129	49183163		50S ribosomal protein L15 [Bacillus anth...	146	Proposed to be essential proteins	Phase 4: April 2009	1VSA	51.4%	Bacillus anthracis

IDP04072 (show subtarget assignments)	1	in_pdb 3OOW 3OPQ	No	FTT0896	56707997	purE	phosphoribosylaminoimidazole carboxylase...	163	conserved gene; putative drug target function;	Phase 4: April 2009	3OOW	100%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04073 (show subtarget assignments)	1	crystallized	No	YPO0502	115346311		conserved hypothetical protein [Yersinia...	172	virulence factor; conserved gene;	Phase 4: April 2009	1Y12	38.4%	Yersinia pestis	Hypothetical proteins	Conserved

IDP04074 (show subtarget assignments)	1	cloned	No	BAS4469	49187464		50S ribosomal protein L20 [Bacillus anth...	118	Proposed to be essential proteins	Phase 4: April 2009	1VS6	55.1%	Bacillus anthracis

IDP04075 (show subtarget assignments)	8	selected	No	CAC05807	12329076	icsB	IcsB, function unknown [Shigella flexner...	494	Shigella effector protein	Community Requests			Shigella flexneri

IDP04076 (show subtarget assignments)	1	expressed	No	GBAA2213	47527506		sensor histidine kinase [Bacillus anthra...	452	putative drug target function;	Phase 4: April 2009	2C2A	18.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04077 (show subtarget assignments)	1	crystallized	No	FTT1793c	56708781	pepN	aminopeptidase N [Francisella tularensis...	864	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2DQ6	48.9%	Francisella tularensis

IDP04078 (show subtarget assignments)	1	expressed	No	YPCD1.09c	5832432	YPCD1.09c	hypothetical protein YPCD1.09c [Yersinia...	91	virulence factor; conserved gene;	Phase 4: April 2009	3KXE	29.7%	Yersinia pestis	Hypothetical proteins	Conserved

IDP04079 (show subtarget assignments)	1	purified	No	BAS0100	49183134		50S ribosomal protein L7/L12 [Bacillus a...	119	Proposed to be essential proteins	Phase 4: April 2009	1DD3	63.3%	Bacillus anthracis

IDP04080 (show subtarget assignments)	1	cloned	No	BAS0123	49183157		30S ribosomal protein S14 [Bacillus anth...	61	Proposed to be essential proteins	Phase 4: April 2009	1FJG	73.8%	Bacillus anthracis

IDP04081 (show subtarget assignments)	1	purified	No	BAS0361	49183389		DNA topoisomerase III [Bacillus anthraci...	729	Proposed to be essential proteins	Phase 4: April 2009	1D6M	27.7%	Bacillus anthracis

IDP04082 (show subtarget assignments)	1	cloned	No	YPO1596	115347343	plsX	fatty acid/phospholipid synthesis protei...	344	conserved gene; putative drug target function;	Phase 4: April 2009	1U7N	34.9%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04083 (show subtarget assignments)	1	cloned	No	YPO1631	218928767	pepT	peptidase T [Yersinia pestis CO92]	411	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1FNO	76.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04084 (show subtarget assignments)	1	cloned	No	VC2561	15642556		uroporphyrin-III C-methyltransferase [Vi...	299	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1PJQ	50.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04085 (show subtarget assignments)	1	expressed	No	VC0525	15640547		2-amino-4-hydroxy-6-hydroxymethyldihydro...	195	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2BMB	30.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04086 (show subtarget assignments)	1	expressed	No	VC2256	15642254		undecaprenyl diphosphate synthase [Vibri...	256	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1JP3	54.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04087 (show subtarget assignments)	1	cloned	No	CPF_2394	110799648	minC	septum formation inhibitor [Clostridium ...	211	conserved gene; putative drug target function;	Phase 4: April 2009	1HF2	29.7%	Clostridium perfringens	Cellular processes	Cell division

IDP04088 (show subtarget assignments)	1	soluble	No	CPF_2931	110800177		putative lipoprotein [Clostridium perfri...	184	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04089 (show subtarget assignments)	1	expressed	No	STM1952_1_222	16765290	yecS	putative ABC-type amino acid transporter...	222	Salmonella essential protein	Phase 4: April 2009	2R6G	24.3%	Salmonella enterica

IDP04090 (show subtarget assignments)	1	crystallized	No	CPF_0694	110800453	aroK	shikimate kinase [Clostridium perfringen...	167	conserved gene; putative drug target function;	Phase 4: April 2009	2PT5	34.1%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP04091 (show subtarget assignments)	1	cloned	No	CPF_1278	110799680		putative lipoprotein [Clostridium perfri...	155	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04092 (show subtarget assignments)	1	cloned	No	CPF_1925	110801017	spoVS	stage V sporulation protein S [Clostridi...	86	conserved gene; putative drug target function;	Phase 4: April 2009	2EH1	57%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04093 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1907	218929023	irp5	yersiniabactin siderophore biosynthetic ...	525	drug target; virulence factor; conserved gene; putative drug target function;...	Phase 4: April 2009	1MD9	47.8%	Yersinia pestis	Cellular processes	Cell division

IDP04094 (show subtarget assignments)	1	expressed	No	YPO1966	218929080	astE	succinylglutamate desuccinylase [Yersini...	330	conserved gene; putative drug target function;	Phase 4: April 2009	1YW6	47.9%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04095 (show subtarget assignments)	1	expressed	No	YPO1987	115347708		hypothetical protein [Yersinia pestis CO...	552	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP02830
(show subtarget assignments)

1

soluble

No

GBAA4861

47530155

pepQ-2

proline dipeptidase [Bacillus anthracis ...

365

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

1WY2

38.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02831
(show subtarget assignments)

1

crystallized

No

GBAA4686

47529986

maf

Maf-like protein [Bacillus anthracis str...

191

Conserved; Drug target functions

Phase 3: June 2008

1EX2

53.4%

Bacillus anthracis

Cellular processes

Cell division

IDP02832
(show subtarget assignments)

1

expressed

No

FTT1518

56708554

ogt

methylated-DNA--protein-cysteine methylt...

190

Conserved; Drug target functions

Phase 3: June 2008

1SFE

28.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy

Heme, porphyrin, and cobalaminOther,tRNA and rRNA base modification

IDP02833
(show subtarget assignments)

1

cloned

No

GBAA4561

47529857

aroE

shikimate 5-dehydrogenase [Bacillus anth...

308

Conserved; Drug target functions

Phase 3: June 2008

2EGG

49.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02834
(show subtarget assignments)

1

expressed

No

GBAA4975

47530273

moaC

molybdenum cofactor biosynthesis protein...

161

Conserved; Drug target functions

Phase 3: June 2008

2EEY

69.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP02835
(show subtarget assignments)

1

expressed

No

FTT0631

56707756

hflX

protease, GTP-binding subunit [Francisel...

435

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2QTF

22.8%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02836
(show subtarget assignments)

1

crystallized

No

GBAA4423

47529716

aroQ

3-dehydroquinate dehydratase [Bacillus a...

146

Conserved; Drug target functions

Phase 3: June 2008

1GQO

57.5%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP04002
(show subtarget assignments)

8

selected

No

CAC05806

12329075

ipgA

IpgA, similarities to IpgE, putative cha...

129

Shigella effector protein

Community Requests

Shigella flexneri

IDP04003
(show subtarget assignments)

1

cloned

No

BAS0126

49183160

50S ribosomal protein L18 [Bacillus anth...

120

Proposed to be essential proteins

Phase 4: April 2009

1OVY

75.8%

Bacillus anthracis

IDP04004
(show subtarget assignments)

1

cloned

No

CPF_1305

110799423

mtnN

5'-methylthioadenosine/S-adenosylhomocys...

266

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3EEI

34.6%

Clostridium perfringens

Central intermediary metabolism

Other

IDP04005
(show subtarget assignments)

1

purified

No

BAS4355

49187350

valyl-tRNA synthetase [Bacillus anthraci...

881

Proposed to be essential proteins

Phase 4: April 2009

1GAX

42.6%

Bacillus anthracis

IDP04006
(show subtarget assignments)

1

cloned

No

CPF_1351

110800739

putative lipoprotein [Clostridium perfri...

264

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04007
(show subtarget assignments)

1

expressed

No

VC1319

15641331

sensor histidine kinase [Vibrio cholerae...

440

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Vibrio cholerae

Regulatory functions

Other

IDP04008
(show subtarget assignments)

1

cloned

No

YPO0906

218928079

gcsH

glycine cleavage system protein H [Yersi...

128

conserved gene; putative drug target function;

Phase 4: April 2009

3A7A

75%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04009
(show subtarget assignments)

1

cloned

No

VC2277

15642275

xanthine-guanine phosphoribosyltransfera...

154

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A95

68.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP04010
(show subtarget assignments)

1

cloned

No

CPF_2393

110798628

minD

septum site-determining protein MinD [Cl...

265

conserved gene; putative drug target function;

Phase 4: April 2009

3Q9L

43.4%

Clostridium perfringens

Cellular processes

Cell division

IDP04011
(show subtarget assignments)

1

cloned

No

CPF_2475

110800353

stage II sporulation protein R [Clostrid...

209

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04012
(show subtarget assignments)

1

cloned

No

CPF_2355

110800506

virJ

sensor histidine kinase [Clostridium per...

482

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

15.4%

Clostridium perfringens

Cellular processes

Pathogenesis

IDP04013
(show subtarget assignments)

1

cloned

No

STM2913_1_498

16766219

putative permease [Salmonella typhimuriu...

498

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04014
(show subtarget assignments)

1

purified

No

YPO3173

115348814

thiI

thiamine biosynthesis protein [Yersinia ...

483

conserved gene; putative drug target function;

Phase 4: April 2009

2C5S

23.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04015
(show subtarget assignments)

1

purified

No

VC0395

15640422

UTP--glucose-1-phosphate uridylyltransfe...

291

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3JUJ

58.1%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

IDP04016
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0834

110798754

arsC

arsenate reductase ArsC [Clostridium per...

132

conserved gene; putative drug target function;

Phase 4: April 2009

2L17

40.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04017
(show subtarget assignments)

1

cloned

No

CPF_1035

110799411

putative lipoprotein [Clostridium perfri...

309

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04018
(show subtarget assignments)

1

cloned

No

CPF_1860

110799668

msrB

methionine sulfoxide reductase B [Clostr...

147

conserved gene; putative drug target function;

Phase 4: April 2009

1XM0

64.6%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04019
(show subtarget assignments)

1

cloned

No

CPF_2080

110799586

spoIIIAH

stage III sporulation protein AH [Clostr...

165

conserved gene; putative drug target function;

Phase 4: April 2009

3TUF

24.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04020
(show subtarget assignments)

1

cloned

No

CPF_2112

110800515

cell division protein FtsQ [Clostridium ...

248

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Cell division

IDP04021
(show subtarget assignments)

1

expressed

No

BAS3695

49186694

30S ribosomal protein S16 [Bacillus anth...

90

Proposed to be essential proteins

Phase 4: April 2009

1EMW

42.2%

Bacillus anthracis

IDP04022
(show subtarget assignments)

1

cloned

No

BAS0095

49183129

preprotein translocase subunit SecE [Bac...

59

Proposed to be essential proteins

Phase 4: April 2009

3DIN

33.9%

Bacillus anthracis

IDP04023
(show subtarget assignments)

1

cloned

No

YPO0511a

115346321

hypothetical protein [Yersinia pestis CO...

121

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04024
(show subtarget assignments)

1

cloned

No

BAS5319

49188303

DNA-binding response regulator YycF [Bac...

235

Proposed to be essential proteins

Phase 4: April 2009

2OQR

47.7%

Bacillus anthracis

IDP04025
(show subtarget assignments)

1

expressed

No

YPCD1.36c

16082724

yscX

hypothetical protein YPCD1.36c [Yersinia...

122

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04026
(show subtarget assignments)

1

expressed

No

FTT0456c

56707598

hypothetical protein FTT_0456c [Francise...

97

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1YHD

39.2%

Francisella tularensis

IDP04027
(show subtarget assignments)

1

cloned

No

BAS4637

49187628

leucyl-tRNA synthetase [Bacillus anthrac...

802

Proposed to be essential proteins

Phase 4: April 2009

1H3N

45.9%

Bacillus anthracis

IDP04028
(show subtarget assignments)

1

purified

No

BAS0109

49183143

30S ribosomal protein S10 [Bacillus anth...

102

Proposed to be essential proteins

Phase 4: April 2009

1P6G

61.8%

Bacillus anthracis

IDP04029
(show subtarget assignments)

1

soluble

No

YPO0500

115346309

conserved hypothetical protein [Yersinia...

186

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04030
(show subtarget assignments)

1

cloned

No

YPO2532

115348229

hypothetical protein [Yersinia pestis CO...

70

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04031
(show subtarget assignments)

1

cloned

No

CBU_A0011

29648123

hypothetical protein CBUA0011 [Coxiella ...

56

drug target;

Phase 4: April 2009

Coxiella burnetii

Hypothetical proteins

Domain

IDP04032
(show subtarget assignments)

1

cloned

No

CPF_2081

110798910

stage III sporulation protein AG [Clostr...

201

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04033
(show subtarget assignments)

1

soluble

No

VC1950

15641952

biotin sulfoxide reductase [Vibrio chole...

815

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1E18

48.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04034
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0128

49183162

50S ribosomal protein L30 [Bacillus anth...

60

Proposed to be essential proteins

Phase 4: April 2009

1VS6

53.3%

Bacillus anthracis

IDP04035
(show subtarget assignments)

1

in_pdb
3P0R

Yes

BAS5262

49188247

azoreductase [Bacillus anthracis str. St...

208

Proposed to be essential proteins

Phase 4: April 2009

3P0R

100%

Bacillus anthracis

IDP04036
(show subtarget assignments)

1

cloned

No

CPF_1970

110800938

smc

chromosome segregation protein SMC [Clos...

1185

conserved gene; putative drug target function;

Phase 4: April 2009

3AUX

8.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04037
(show subtarget assignments)

1

in_pdb
3S52

No

YPO2082

115347800

putative fumarylacetoacetate hydrolase f...

218

putative drug target function;

Phase 4: April 2009

3S52

100%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04038
(show subtarget assignments)

1

expressed

No

YPCD1.65

5832485

YPCD1.65

putative transposase [Yersinia pestis CO...

102

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04039
(show subtarget assignments)

1

cloned

No

CPF_2446

110800060

spoIIID

stage III sporulation protein D [Clostri...

83

conserved gene; putative drug target function;

Phase 4: April 2009

2L0K

60.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04040
(show subtarget assignments)

1

cloned

No

CPF_1068

110800949

cotJC

spore coat protein CotJC [Clostridium pe...

188

conserved gene; putative drug target function;

Phase 4: April 2009

1JKU

34.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04041
(show subtarget assignments)

1

cloned

No

YPCD1.16c

5832438

YPCD1.16c

hypothetical protein YPCD1.16c [Yersinia...

107

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP04042
(show subtarget assignments)

1

cloned

No

CPF_0296

110798725

putative cell division ATP-binding prote...

228

conserved gene; putative drug target function;

Phase 4: April 2009

1F3O

40.6%

Clostridium perfringens

Cellular processes

Cell division

IDP04043
(show subtarget assignments)

1

soluble

No

VCA0565

15601324

sensor histidine kinase [Vibrio cholerae...

499

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BXD

6%

Vibrio cholerae

Regulatory functions

Other

IDP04044
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1530

56708564

fadB/acbP

fusion product of 3-hydroxacyl-CoA dehyd...

898

drug target; conserved gene;

Phase 4: April 2009

3K6J

11.7%

Francisella tularensis

Fatty acid and phospholipid metabolism

Degradation

IDP04045
(show subtarget assignments)

1

soluble

No

FTT1747

56708745

outer membrane protein [Francisella tula...

191

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Francisella tularensis

IDP04046
(show subtarget assignments)

1

cloned

No

YPCD1.78c

16082765

tap

repA translation protein [Yersinia pesti...

24

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04047
(show subtarget assignments)

1

cloned

No

YPCD1.92

5832507

YPCD1.92

hypothetical protein YPCD1.92 [Yersinia ...

109

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04048
(show subtarget assignments)

1

in_crystallization_trials

No

VC1112

15641125

biotin synthase [Vibrio cholerae O1 biov...

350

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1R30

69.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04049
(show subtarget assignments)

1

soluble

No

VC1132

15641145

hisG

ATP phosphoribosyltransferase [Vibrio ch...

304

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1H3D

65.8%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP04050
(show subtarget assignments)

1

purified

No

YPO1765

218928887

hpaF

5-carboxymethyl-2-hydroxymuconate delta-...

132

conserved gene; putative drug target function;

Phase 4: April 2009

1OTG

67.4%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04051
(show subtarget assignments)

1

expressed

No

YPO0511

115346320

hypothetical protein [Yersinia pestis CO...

205

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04052
(show subtarget assignments)

1

cloned

No

CPF_0049

110799596

putative lipoprotein [Clostridium perfri...

167

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04053
(show subtarget assignments)

1

cloned

No

CPF_2307

110801393

spoIIAA

anti-sigma F factor antagonist [Clostrid...

111

conserved gene; putative drug target function;

Phase 4: April 2009

1TH8

45%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04054
(show subtarget assignments)

1

soluble

No

YPO0508

115346317

hypothetical protein [Yersinia pestis CO...

190

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Other

IDP04055
(show subtarget assignments)

1

cloned

No

STM0301_1_836

16763684

safC

putative fimbrial usher [Salmonella typh...

836

Salmonella essential protein

Phase 4: April 2009

3RFZ

37%

Salmonella enterica

IDP04057
(show subtarget assignments)

1

purified

No

BAS0125

49183159

50S ribosomal protein L6 [Bacillus anthr...

179

Proposed to be essential proteins

Phase 4: April 2009

1C04

74.9%

Bacillus anthracis

IDP04058
(show subtarget assignments)

1

soluble

No

CPF_0556

110800185

ABC transporter, solute-binding protein ...

461

drug target; putative drug target function;

Phase 4: April 2009

1EU8

18.9%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04059
(show subtarget assignments)

1

expressed

No

VC1973

9656513

naphthoate synthase [Vibrio cholerae O1 ...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3H02

80.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04060
(show subtarget assignments)

8

selected

No

CAC05813

12329082

mxiI

MxiI, component of the Mxi-Spa secretion...

97

Shigella effector protein

Community Requests

Shigella flexneri

IDP04061
(show subtarget assignments)

1

cloned

No

YPCD1.07

5832430

YPCD1.07

hypothetical protein YPCD1.07 [Yersinia ...

98

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04062
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0637

9658051

oxygen-insensitive NAD(P)H nitroreductas...

217

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HZN

59.4%

Vibrio cholerae

Central intermediary metabolism

Other

IDP04063
(show subtarget assignments)

1

cloned

No

CPF_0514

110800714

putative lipoprotein [Clostridium perfri...

176

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04064
(show subtarget assignments)

1

expressed

No

BAS0127

49183161

30S ribosomal protein S5 [Bacillus anthr...

166

Proposed to be essential proteins

Phase 4: April 2009

1PKP

75.3%

Bacillus anthracis

IDP04065
(show subtarget assignments)

1

cloned

No

CPF_2985

110800289

yyaC

putative sporulation protein YyaC [Clost...

196

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04066
(show subtarget assignments)

8

selected

No

CAC05819

12329088

mxiE

MxiE, similarities to transcriptional ac...

210

Shigella effector protein

Community Requests

Shigella flexneri

IDP04067
(show subtarget assignments)

1

purified

No

BAS4417

49187412

thioredoxin [Bacillus anthracis str. Ste...

104

Proposed to be essential proteins

Phase 4: April 2009

2GZY

75%

Bacillus anthracis

IDP04068
(show subtarget assignments)

1

expressed

No

YPCD1.94n

40548799

hypothetical protein YPCD1.94n [Yersinia...

251

virulence factor;

Phase 4: April 2009

1A5V

15.1%

Yersinia pestis

IDP04069
(show subtarget assignments)

1

in_pdb
3R3T

Yes

BAS5327

49188311

30S ribosomal protein S6 [Bacillus anthr...

96

Proposed to be essential proteins

Phase 4: April 2009

3R3T

100%

Bacillus anthracis

IDP04070
(show subtarget assignments)

1

cloned

No

FTT0073

56707252

sdhD

succinate dehydrogenase hydrophobic memb...

122

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NEK

26.2%

Francisella tularensis

IDP04071
(show subtarget assignments)

1

cloned

No

BAS0129

49183163

50S ribosomal protein L15 [Bacillus anth...

146

Proposed to be essential proteins

Phase 4: April 2009

1VSA

51.4%

Bacillus anthracis

IDP04072
(show subtarget assignments)

1

in_pdb
3OOW
3OPQ

No

FTT0896

56707997

purE

phosphoribosylaminoimidazole carboxylase...

163

conserved gene; putative drug target function;

Phase 4: April 2009

3OOW

100%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04073
(show subtarget assignments)

1

crystallized

No

YPO0502

115346311

conserved hypothetical protein [Yersinia...

172

virulence factor; conserved gene;

Phase 4: April 2009

1Y12

38.4%

Yersinia pestis

Hypothetical proteins

Conserved

IDP04074
(show subtarget assignments)

1

cloned

No

BAS4469

49187464

50S ribosomal protein L20 [Bacillus anth...

118

Proposed to be essential proteins

Phase 4: April 2009

1VS6

55.1%

Bacillus anthracis

IDP04075
(show subtarget assignments)

8

selected

No

CAC05807

12329076

icsB

IcsB, function unknown [Shigella flexner...

494

Shigella effector protein

Community Requests

Shigella flexneri

IDP04076
(show subtarget assignments)

1

expressed

No

GBAA2213

47527506

sensor histidine kinase [Bacillus anthra...

452

putative drug target function;

Phase 4: April 2009

2C2A

18.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04077
(show subtarget assignments)

1

crystallized

No

FTT1793c

56708781

pepN

aminopeptidase N [Francisella tularensis...

864

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2DQ6

48.9%

Francisella tularensis

IDP04078
(show subtarget assignments)

1

expressed

No

YPCD1.09c

5832432

YPCD1.09c

hypothetical protein YPCD1.09c [Yersinia...

91

virulence factor; conserved gene;

Phase 4: April 2009

3KXE

29.7%

Yersinia pestis

Hypothetical proteins

Conserved

IDP04079
(show subtarget assignments)

1

purified

No

BAS0100

49183134

50S ribosomal protein L7/L12 [Bacillus a...

119

Proposed to be essential proteins

Phase 4: April 2009

1DD3

63.3%

Bacillus anthracis

IDP04080
(show subtarget assignments)

1

cloned

No

BAS0123

49183157

30S ribosomal protein S14 [Bacillus anth...

61

Proposed to be essential proteins

Phase 4: April 2009

1FJG

73.8%

Bacillus anthracis

IDP04081
(show subtarget assignments)

1

purified

No

BAS0361

49183389

DNA topoisomerase III [Bacillus anthraci...

729

Proposed to be essential proteins

Phase 4: April 2009

1D6M

27.7%

Bacillus anthracis

IDP04082
(show subtarget assignments)

1

cloned

No

YPO1596

115347343

plsX

fatty acid/phospholipid synthesis protei...

344

conserved gene; putative drug target function;

Phase 4: April 2009

1U7N

34.9%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04083
(show subtarget assignments)

1

cloned

No

YPO1631

218928767

pepT

peptidase T [Yersinia pestis CO92]

411

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1FNO

76.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04084
(show subtarget assignments)

1

cloned

No

VC2561

15642556

uroporphyrin-III C-methyltransferase [Vi...

299

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1PJQ

50.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04085
(show subtarget assignments)

1

expressed

No

VC0525

15640547

2-amino-4-hydroxy-6-hydroxymethyldihydro...

195

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2BMB

30.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04086
(show subtarget assignments)

1

expressed

No

VC2256

15642254

undecaprenyl diphosphate synthase [Vibri...

256

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1JP3

54.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04087
(show subtarget assignments)

1

cloned

No

CPF_2394

110799648

minC

septum formation inhibitor [Clostridium ...

211

conserved gene; putative drug target function;

Phase 4: April 2009

1HF2

29.7%

Clostridium perfringens

Cellular processes

Cell division

IDP04088
(show subtarget assignments)

1

soluble

No

CPF_2931

110800177

putative lipoprotein [Clostridium perfri...

184

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04089
(show subtarget assignments)

1

expressed

No

STM1952_1_222

16765290

yecS

putative ABC-type amino acid transporter...

222

Salmonella essential protein

Phase 4: April 2009

2R6G

24.3%

Salmonella enterica

IDP04090
(show subtarget assignments)

1

crystallized

No

CPF_0694

110800453

aroK

shikimate kinase [Clostridium perfringen...

167

conserved gene; putative drug target function;

Phase 4: April 2009

2PT5

34.1%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP04091
(show subtarget assignments)

1

cloned

No

CPF_1278

110799680

putative lipoprotein [Clostridium perfri...

155

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04092
(show subtarget assignments)

1

cloned

No

CPF_1925

110801017

spoVS

stage V sporulation protein S [Clostridi...

86

conserved gene; putative drug target function;

Phase 4: April 2009

2EH1

57%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04093
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1907

218929023

irp5

yersiniabactin siderophore biosynthetic ...

525

drug target; virulence factor; conserved gene; putative drug target function;...

Phase 4: April 2009

1MD9

47.8%

Yersinia pestis

Cellular processes

Cell division

IDP04094
(show subtarget assignments)

1

expressed

No

YPO1966

218929080

astE

succinylglutamate desuccinylase [Yersini...

330

conserved gene; putative drug target function;

Phase 4: April 2009

1YW6

47.9%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04095
(show subtarget assignments)

1

expressed

No

YPO1987

115347708

hypothetical protein [Yersinia pestis CO...

552

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

Targets