Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91984 (show subtarget assignments)	8	selected	No	SpneCM_010100008317	298255584		spfh domain/band 7 family protein [Strep...	299	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3BK6	17.1%	Streptococcus pneumoniae

IDP91935 (show subtarget assignments)	8	selected	No	SpneCM_010100001517	298254278		heat shock protein HtpX [Streptococcus p...	299	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3CQB	11.7%	Streptococcus pneumoniae

IDP04084 (show subtarget assignments)	1	cloned	No	VC2561	15642556		uroporphyrin-III C-methyltransferase [Vi...	299	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1PJQ	50.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90558 (show subtarget assignments)	8	purified	No	Cj0912c	15792241	cysM	cysteine synthase A [Campylobacter jejun...	299	Predicted Essential	Community Requests	1O58	52.5%	Campylobacter jejuni

IDP90837 (show subtarget assignments)	8	selected	No	S2226	30063491	rfbD	dTDP-4-dehydrorhamnose reductase [Shigel...	299	Predicted Essential	Community Requests	1KBZ	85.6%	Shigella flexneri

IDP00678 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1624	57286146	era	GTP-binding protein Era	299	Conserved Gene / Pathway	Phase 2: March 2008	3IEV	45.2%	Staphylococcus aureus	Cellular processes	Cell division

IDP91833 (show subtarget assignments)	8	selected	No	SSUSC84_0046	253750968		DNA-binding protein [Streptococcus suis ...	299	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus suis

IDP90136 (show subtarget assignments)	8	expressed	No	MPXV_ZAI1979_005_177	68449248		ser/thr kinase [Monkeypox virus]	299	essential for viral DNA replication, similar to VACV-COP-B1R, MPXV-ZAI96-B3R	Community Requests	2V62	40.4%	Monkeypox virus

IDP90192 (show subtarget assignments)	8	cloned	No	AAM13635.1	20153174	CPXV196 CDS	CPXV196 protein	299	serine-threonine kinase	Community Requests	2KTY	40.7%	Cowpox virus	Unknown function	0

IDP91836 (show subtarget assignments)	8	selected	No	GALLO_0038	288904261		Cro/CI family transcriptional regulator ...	299	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus gallolyticus

IDP90560 (show subtarget assignments)	8	in_crystallization_trials	No	YPO2014	16122257	ipk	4-diphosphocytidyl-2-C-methyl-D-erythrit...	299	Predicted Essential	Community Requests	1OJ4	70.9%	Yersinia pestis

IDP91187 (show subtarget assignments)	1	in_pdb 3UZR 4DCA	Yes	AF207840_1	10130002	aph(2')-Ib	aminoglycoside phosphotransferase [Enter...	299	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3HAM	100%	Enterococcus faecium

IDP90801 (show subtarget assignments)	8	soluble	No	Cj1597	15792902	hisG	ATP phosphoribosyltransferase [Campyloba...	299	Predicted Essential	Community Requests	1H3D	66.2%	Campylobacter jejuni

IDP02205 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0259	56707415	hemC	hydroxymethylbilane synthase (porphobili...	300	Conserved; Drug target functions	Phase 3: June 2008	1AH5	54.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01070 (show subtarget assignments)	1	expressed	No	STM3949	16767219	xerC	site-specific tyrosine recombinase XerC ...	300	Drug Target Function	Phase 2: March 2008	1A0P	37.3%	Salmonella enterica	Cellular processes	Cell division

IDP05681 (show subtarget assignments)	1	cloned	No	lmo1277	16803317	codV	hypothetical protein lmo1277 [Listeria m...	300	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1A0P	35%	Listeria monocytogenes	Mobile and extrachromosomal element functions: Prophage functions

IDP91601 (show subtarget assignments)	8	cloned	No	CBU_2052	29542603		hypothetical protein	300	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP05270 (show subtarget assignments)	1	soluble	No	lmo1016	16803056	gbuC	hypothetical protein lmo1016 [Listeria m...	249	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2B4L	51%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP91834 (show subtarget assignments)	8	selected	No	HMPREF9176_0709	312864359		DNA-binding helix-turn-helix protein [St...	300	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus downei

IDP91835 (show subtarget assignments)	8	selected	No	HMPREF0819_1750	320548064		DNA-binding protein [Streptococcus equin...	300	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus equinus

IDP91858 (show subtarget assignments)	8	cloned	No	NP_734518	25010123		hypothetical protein gbs0048 [Streptococ...	300	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus agalactiae

IDP90228 (show subtarget assignments)	1	in_pdb 3T5P 3S40	No	BAS4713	49187704	-	Transcription regulator [contains diacyl...	300	Transcription regulator [contains diacylglycerol kinase catalytic domain]; Predi...	January 2009	3S40	100%	Bacillus anthracis

IDP01164 (show subtarget assignments)	1	purified	No	BA_5600	30260056		ABC transporter, ATP-binding protein	300	Conserved Gene / Pathway	Phase 2: March 2008	2YYZ	31.3%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02313 (show subtarget assignments)	1	cloned	No	GBAA3973	47529263	sucD	succinyl-CoA synthetase subunit alpha [B...	300	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JKJ	62.3%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP91262 (show subtarget assignments)	8	soluble	No	NT05BA0365	49177263		conserved hypothetical protein TIGR00147...	301	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2QV7	49.5%	Bacillus anthracis	Hypothetical proteins: Conserved

IDP05217 (show subtarget assignments)	1	in_crystallization_trials	No	CD3421	126701044	hemC	porphobilinogen deaminase [Clostridium d...	301	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1PDA	37.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05258 (show subtarget assignments)	1	soluble	No	CD2761	126700377		putative N-acetylmuramoyl-L-alanine amid...	301	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1JWQ	23.9%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00015 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4048	47605856		UDP-N-acetylenolpyruvoylglucosamine redu...	301	Drug Target Homolog	Phase 1: October 2007	1HSK	39.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91198 (show subtarget assignments)	8	cloned	No	BAS5131	49188117	-	stage II sporulation protein	301	essential/virulence/pathogenesis / Essential proteins	Community Requests	3TUF	33.6%	Bacillus anthracis

IDP91793 (show subtarget assignments)	8	in_crystallization_trials	No	BAA03776	807707	mphA	macrolide 2'-phosphotransferase I [Esche...	301	other biological interest / Kinase	Community Requests	3TDV	21.3%	Escherichia coli

IDP01997 (show subtarget assignments)	1	cloned	No	STM4310	16767560		putative inner membrane protein [Salmone...	301	Conserved; Drug target functions	Phase 3: June 2008	3QQZ	29.6%	Salmonella enterica	Unknown function	General

IDP91864 (show subtarget assignments)	8	selected	No	ZP_08398653	332522401		transcriptional regulator, Cro/CI family...	301	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus porcinus

IDP91189 (show subtarget assignments)	1	in_pdb 4DE4 4DFB 4DFU	Yes	AAW59417	57918602	aph(2'')-Id	APH(2'')-Id [Enterococcus faecium]	301	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LZH	100%	Enterococcus faecium

IDP02406 (show subtarget assignments)	1	crystallized	No	GBAA2768	47528059		thioredoxin reductase, putative [Bacillu...	301	Conserved; Essential; Drug target functions	Phase 3: June 2008	3FBS	32.1%	Bacillus anthracis	Energy metabolism	Electron transport

IDP91794 (show subtarget assignments)	8	crystallized	No	BAA12910	1695688	mphB	macrolide 2'-phosphotransferase II [Esch...	302	other biological interest / Kinase	Community Requests	3TDW	18.5%	Escherichia coli

IDP00555 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3424	16123573	nadC	quinolinate phosphoribosyltransferase	302	Conserved Gene / Pathway	Phase 2: March 2008	1QAP	72.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00119 (show subtarget assignments)	1	purified	No	NT01ST0753	16763999	citE	citrate lyase beta chain	302	Essential	Phase 1: October 2007	1SGJ	32.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP91370 (show subtarget assignments)	8	expressed	No	VV1_2349	27365668		lactonizing lipase [Vibrio vulnificus CM...	302	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1EX9	55%	Vibrio vulnificus

IDP01040 (show subtarget assignments)	1	expressed	No	STM2935	16766241	cysD	sulfate adenylyltransferase subunit 2	302	Conserved Gene / Pathway	Phase 2: March 2008	1ZUN	75.2%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP02080 (show subtarget assignments)	1	in_pdb 3KZ2 3IH1	No	GBAA2350	47527645	yqiQ	carboxyvinyl-carboxyphosphonate phosphor...	302	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3IH1	100%	Bacillus anthracis	Central intermediary metabolism	Other

IDP02079 (show subtarget assignments)	1	expressed	No	Cj0173c	15791560		iron ABC transporter, ATP binding subuni...	302	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2D62	35.4%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00966 (show subtarget assignments)	1	expressed	No	STM1552	16764897		putative cytoplasmic protein	302	Essential Gene	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP04638 (show subtarget assignments)	1	expressed	No	FTT0372c	56707523	accD	Acetyl-CoA carboxylase beta subunit [Fra...	302	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	60.3%	Francisella tularensis

IDP05439 (show subtarget assignments)	1	soluble	No	lmo2499	16804537	-	hypothetical protein lmo2499 [Listeria m...	302	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4ECF	53.6%	Listeria monocytogenes	Transport and binding proteins: Anions

IDP91837 (show subtarget assignments)	8	selected	No	STRINF_00393	171778363		hypothetical protein STRINF_00393 [Strep...	302	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus infantarius

IDP01402 (show subtarget assignments)	1	cloned	No	VC0843	15640860		tagE protein	302	Drug Target Function	Phase 2: March 2008	3SLU	18.9%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP05522 (show subtarget assignments)	1	cloned	No	CD2240	126699857	nanA	N-acetylneuraminate lyase [Clostridium d...	302	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1F5Z	69.9%	Clostridium difficile	Central intermediary metabolism: Amino sugars

IDP91859 (show subtarget assignments)	8	cloned	No	SAK_0081	76788347		DNA-binding protein [Streptococcus agala...	302	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus agalactiae

IDP90719 (show subtarget assignments)	8	soluble	No	Cj0503c	15791865	hemH	ferrochelatase [Campylobacter jejuni sub...	303	Predicted Essential	Community Requests	2PO7	31%	Campylobacter jejuni

IDP00540 (show subtarget assignments)	1	purified	No	YPO2719	16122923	era	GTP-binding protein Era	303	Conserved Gene / Pathway	Phase 2: March 2008	1EGA	83.8%	Yersinia pestis	Cellular processes	Cell division

IDP91865 (show subtarget assignments)	8	selected	No	SpyM50034	139472918		DNA-binding protein [Streptococcus pyoge...	303	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus pyogenes

IDP91866 (show subtarget assignments)	8	expressed	No	SPy_0037	15674279		hypothetical protein SPy_0037 [Streptoco...	303	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus pyogenes

IDP91369 (show subtarget assignments)	8	in_pdb 4DB3	No	VV1_2570	326424042		N-acetyl-D-glucosamine kinase [Vibrio vu...	303	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	4DB3	100%	Vibrio vulnificus

IDP91866 (show subtarget assignments)	8	expressed	No	SPy_0037	15674279		hypothetical protein SPy_0037 [Streptoco...	303	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus pyogenes

IDP00445 (show subtarget assignments)	1	purified	No	YPO3843	16123978	xerC	site-specific tyrosine recombinase XerC ...	303	Conserved Gene / Pathway	Phase 2: March 2008	1A0P	35.6%	Yersinia pestis	DNA metabolism	DNA replication, recombination, and repair

IDP91860 (show subtarget assignments)	8	cloned	No	SAG0048	22536233		Cro/CI family transcriptional regulator ...	303	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus agalactiae

IDP92001 (show subtarget assignments)	8	selected	No	SpneCM_010100005688	298255086		hypothetical protein SpneCM_05688 [Strep...	303	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP91044 (show subtarget assignments)	8	in_crystallization_trials	No	EFA0002	110556113	vanY	vanY [Enterococcus faecalis]	303	drug resistance / A carboxypeptidase thought to be involved in breakdown of normal cell wall	Community Requests			Enterococcus faecalis

IDP91861 (show subtarget assignments)	8	selected	No	SDEG_0056	251781503		transcriptional regulator [Streptococcus...	303	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus dysgalactiae

IDP01392 (show subtarget assignments)	1	purified	No	VC0648	15640668		lipoprotein NlpI	303	Conserved Gene / Pathway	Phase 2: March 2008	1XNF	44.2%	Vibrio cholerae	Cell envelope	Other

IDP90986 (show subtarget assignments)	8	cloned	No	y0974	22124881	rdgC	recombination associated protein [Yersin...	303	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests	2OWL	83.2%	Yersinia pestis

IDP02481 (show subtarget assignments)	1	cloned	No	Cj1139c	15792464		putative galactosyltransferase [Campylob...	303	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3BCV	24.1%	Campylobacter jejuni	DNA metabolism	DNA replication, recombination, and repair

IDP00307 (show subtarget assignments)	1	expressed	No	CBU_0142	29653500	lpxC	UDP-3-0-acyl N-acetylglucosamine deacety...	303	Drug Target Function	Phase 2: March 2008	2VES	65.7%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91568 (show subtarget assignments)	8	in_crystallization_trials	No	BAB35237	13361279	ECs1814	hypothetical protein [Escherichia coli O...	303	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP05312 (show subtarget assignments)	1	soluble	No	CD0895	126698472		metallo-beta-lactamase superfamily expor...	304	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Unknown function: General

IDP04123 (show subtarget assignments)	1	expressed	No	YPO2768	115348451	accD	acetyl-coenzyme A carboxylase carboxyl t...	304	conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	84.5%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02056 (show subtarget assignments)	1	expressed	No	CBU_0934	29541521		ABC transporter, ATP-binding protein [Co...	304	Conserved; Drug target functions	Phase 3: June 2008	1VPL	27.6%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP91832 (show subtarget assignments)	8	cloned	No	SMU.61	24378588		putative transcriptional regulator [Stre...	304	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus mutans

IDP90704 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0269c	15791640	ilvE	branched-chain amino acid aminotransfera...	304	Predicted Essential	Community Requests	3U0G	55.6%	Campylobacter jejuni

IDP05740 (show subtarget assignments)	1	cloned	No	CD2372	126699987	nadA	quinolinate synthetase [Clostridium diff...	304	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2QS0	42.1%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP01811 (show subtarget assignments)	1	expressed	No	FTT0908	56708009	parB	chromosome partition protein B [Francise...	304	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	23.7%	Francisella tularensis	Cellular processes	Cell division

IDP01787 (show subtarget assignments)	1	crystallized	No	STM0332	16763712		putative hydrolase/acyltransferase [Salm...	304	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3QYJ	47.4%	Salmonella enterica	Cellular processes	Detoxification

IDP04049 (show subtarget assignments)	1	soluble	No	VC1132	15641145	hisG	ATP phosphoribosyltransferase [Vibrio ch...	304	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1H3D	65.8%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP02775 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4028	47529321	pyrB	aspartate carbamoyltransferase catalytic...	304	Conserved; Drug target functions	Phase 3: June 2008	3R7D	61.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP05224 (show subtarget assignments)	1	cloned	No	VC_0595	9655026		glutamyl-tRNA synthetase-related protein...	304	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NZJ	55.3%	Vibrio cholerae	Unknown function: General

IDP90647 (show subtarget assignments)	8	cloned	No	VC2685	15642680	metF	5,10-methylenetetrahydrofolate reductase...	304	Predicted Essential	Community Requests	1ZP3	75.3%	Vibrio cholerae

IDP91862 (show subtarget assignments)	8	selected	No	SZO_00390	225867654		DNA-binding protein [Streptococcus equi ...	304	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus equi

IDP91832 (show subtarget assignments)	8	cloned	No	SMU.61	24378588		putative transcriptional regulator [Stre...	304	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus mutans

IDP00673 (show subtarget assignments)	1	expressed	No	SACOL1322	57286057		hydrolase, alpha/beta hydrolase fold fam...	304	Drug Target Function	Phase 2: March 2008	3HJU	24.7%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP91348 (show subtarget assignments)	8	soluble	No	VV1_3127	27366393		response regulator [Vibrio vulnificus CM...	304	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3BRE	32.7%	Vibrio vulnificus

IDP01207 (show subtarget assignments)	1	in_pdb 3R5X 3R23	Yes	BA_2610	39930865		D-alanine--D-alanine ligase (D-alanylala...	304	Conserved Gene / Pathway	Phase 2: March 2008	3R23	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05571 (show subtarget assignments)	1	soluble	No	BA_0168	30253677		conserved hypothetical protein [Bacillus...	304	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP05464 (show subtarget assignments)	1	expressed	No	BA_1489	30255419		superoxide dismutase [Bacillus anthracis...	304	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1P7G	35.5%	Bacillus anthracis	Cellular processes: Detoxification

IDP05340 (show subtarget assignments)	1	in_pdb 3UUW	Yes	CD3450	126701073		putative oxidoreductase [Clostridium dif...	305	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	3UUW	100%	Clostridium difficile	Cellular processes: Pathogenesis

IDP91863 (show subtarget assignments)	8	selected	No	STP_0036	333904285		DNA-binding protein [Streptococcus parau...	305	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus parauberis

IDP04235 (show subtarget assignments)	1	cloned	No	CPF_0823	110800089		polysaccharide deacetylase family protei...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W3Z	32.1%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01840 (show subtarget assignments)	1	soluble	No	STM2861	16766167	sitA	putative periplasmic binding protein [Sa...	305	Conserved; Drug target functions	Phase 3: June 2008	1XVL	53.4%	Salmonella enterica	Cell envelope	Other

IDP90988 (show subtarget assignments)	8	expressed	No	y1189	22125092	gltI	glutamate and aspartate transporter subu...	305	other biological interest / -	Community Requests	2IA4	75.7%	Yersinia pestis

IDP90977 (show subtarget assignments)	8	soluble	No	y0320	22124237	oxyR	DNA-binding transcriptional regulator Ox...	305	other biological interest / important global regulator	Community Requests	1I6A	59.7%	Yersinia pestis

IDP05715 (show subtarget assignments)	1	purified	No	BA_0351	30253889		iron compound ABC transporter, iron comp...	305	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HXP	36.1%	Bacillus anthracis	Transport and binding proteins: Cations and iron carrying compounds

IDP00020 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5315	47605857		UDP-N-acetylenolpyruvoylglucosamine redu...	305	Drug Target Homolog	Phase 1: October 2007	1HSK	59.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01331 (show subtarget assignments)	1	purified	No	VC0589	15640610		ABC transporter, ATP-binding protein	305	Conserved Gene / Pathway	Phase 2: March 2008	2PCJ	28.9%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP04563 (show subtarget assignments)	1	soluble	No	CPF_1296	110798598		iron chelate ABC transporter solute-bind...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2CHU	27.9%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP90887 (show subtarget assignments)	8	cloned	No	YPO0104	16120451	menA	1,4-dihydroxy-2-naphthoate octaprenyltra...	305	Predicted Essential	Community Requests			Yersinia pestis

IDP90697 (show subtarget assignments)	8	cloned	No	Cj0098	15791486	fmt	methionyl-tRNA formyltransferase [Campyl...	305	Predicted Essential	Community Requests	3R8X	38%	Campylobacter jejuni

IDP01165 (show subtarget assignments)	1	expressed	No	BA_5650	30260099		ABC transporter, ATP-binding protein	305	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	30.8%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP91796 (show subtarget assignments)	8	in_crystallization_trials	No	AAB49832	1854639		gentamicin resistance protein [Enterococ...	306	other biological interest / Kinase	Community Requests	3TDV	100%	Enterococcus gallinarum

IDP90828 (show subtarget assignments)	8	in_pdb 3TPF	No	Cj0994c	15792321	argF	ornithine carbamoyltransferase [Campylob...	306	Predicted Essential	Community Requests	3TPF	100%	Campylobacter jejuni

IDP00575 (show subtarget assignments)	1	in_pdb 3V4Z	No	YPO0557	16120885	ddl	D-alanine--D-alanine ligase	306	Drug Target Function	Phase 2: March 2008	3V4Z	100%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02189 (show subtarget assignments)	1	cloned	No	YPO0269	16120608		type III secretion system protein [Yersi...	306	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP91984
(show subtarget assignments)

8

selected

No

SpneCM_010100008317

298255584

spfh domain/band 7 family protein [Strep...

299

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3BK6

17.1%

Streptococcus pneumoniae

IDP91935
(show subtarget assignments)

8

selected

No

SpneCM_010100001517

298254278

heat shock protein HtpX [Streptococcus p...

299

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3CQB

11.7%

Streptococcus pneumoniae

IDP04084
(show subtarget assignments)

1

cloned

No

VC2561

15642556

uroporphyrin-III C-methyltransferase [Vi...

299

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1PJQ

50.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90558
(show subtarget assignments)

8

purified

No

Cj0912c

15792241

cysM

cysteine synthase A [Campylobacter jejun...

299

Predicted Essential

Community Requests

1O58

52.5%

Campylobacter jejuni

IDP90837
(show subtarget assignments)

8

selected

No

S2226

30063491

rfbD

dTDP-4-dehydrorhamnose reductase [Shigel...

299

Predicted Essential

Community Requests

1KBZ

85.6%

Shigella flexneri

IDP00678
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1624

57286146

era

GTP-binding protein Era

299

Conserved Gene / Pathway

Phase 2: March 2008

3IEV

45.2%

Staphylococcus aureus

Cellular processes

Cell division

IDP91833
(show subtarget assignments)

8

selected

No

SSUSC84_0046

253750968

DNA-binding protein [Streptococcus suis ...

299

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus suis

IDP90136
(show subtarget assignments)

8

expressed

No

MPXV_ZAI1979_005_177

68449248

ser/thr kinase [Monkeypox virus]

299

essential for viral DNA replication, similar to VACV-COP-B1R, MPXV-ZAI96-B3R

Community Requests

2V62

40.4%

Monkeypox virus

IDP90192
(show subtarget assignments)

8

cloned

No

AAM13635.1

20153174

CPXV196 CDS

CPXV196 protein

299

serine-threonine kinase

Community Requests

2KTY

40.7%

Cowpox virus

Unknown function

0

IDP91836
(show subtarget assignments)

8

selected

No

GALLO_0038

288904261

Cro/CI family transcriptional regulator ...

299

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus gallolyticus

IDP90560
(show subtarget assignments)

8

in_crystallization_trials

No

YPO2014

16122257

ipk

4-diphosphocytidyl-2-C-methyl-D-erythrit...

299

Predicted Essential

Community Requests

1OJ4

70.9%

Yersinia pestis

IDP91187
(show subtarget assignments)

1

in_pdb
3UZR
4DCA

Yes

AF207840_1

10130002

aph(2')-Ib

aminoglycoside phosphotransferase [Enter...

299

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3HAM

100%

Enterococcus faecium

IDP90801
(show subtarget assignments)

8

soluble

No

Cj1597

15792902

hisG

ATP phosphoribosyltransferase [Campyloba...

299

Predicted Essential

Community Requests

1H3D

66.2%

Campylobacter jejuni

IDP02205
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0259

56707415

hemC

hydroxymethylbilane synthase (porphobili...

300

Conserved; Drug target functions

Phase 3: June 2008

1AH5

54.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01070
(show subtarget assignments)

1

expressed

No

STM3949

16767219

xerC

site-specific tyrosine recombinase XerC ...

300

Drug Target Function

Phase 2: March 2008

1A0P

37.3%

Salmonella enterica

Cellular processes

Cell division

IDP05681
(show subtarget assignments)

1

cloned

No

lmo1277

16803317

codV

hypothetical protein lmo1277 [Listeria m...

300

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1A0P

35%

Listeria monocytogenes

Mobile and extrachromosomal element functions: Prophage functions

IDP91601
(show subtarget assignments)

8

cloned

No

CBU_2052

29542603

hypothetical protein

300

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP05270
(show subtarget assignments)

1

soluble

No

lmo1016

16803056

gbuC

hypothetical protein lmo1016 [Listeria m...

249

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2B4L

51%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP91834
(show subtarget assignments)

8

selected

No

HMPREF9176_0709

312864359

DNA-binding helix-turn-helix protein [St...

300

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus downei

IDP91835
(show subtarget assignments)

8

selected

No

HMPREF0819_1750

320548064

DNA-binding protein [Streptococcus equin...

300

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus equinus

IDP91858
(show subtarget assignments)

8

cloned

No

NP_734518

25010123

hypothetical protein gbs0048 [Streptococ...

300

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus agalactiae

IDP90228
(show subtarget assignments)

1

in_pdb
3T5P
3S40

No

BAS4713

49187704

-

Transcription regulator [contains diacyl...

300

Transcription regulator [contains diacylglycerol kinase catalytic domain]; Predi...

January 2009

3S40

100%

Bacillus anthracis

IDP01164
(show subtarget assignments)

1

purified

No

BA_5600

30260056

ABC transporter, ATP-binding protein

300

Conserved Gene / Pathway

Phase 2: March 2008

2YYZ

31.3%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02313
(show subtarget assignments)

1

cloned

No

GBAA3973

47529263

sucD

succinyl-CoA synthetase subunit alpha [B...

300

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JKJ

62.3%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP91262
(show subtarget assignments)

8

soluble

No

NT05BA0365

49177263

conserved hypothetical protein TIGR00147...

301

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2QV7

49.5%

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05217
(show subtarget assignments)

1

in_crystallization_trials

No

CD3421

126701044

hemC

porphobilinogen deaminase [Clostridium d...

301

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1PDA

37.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05258
(show subtarget assignments)

1

soluble

No

CD2761

126700377

putative N-acetylmuramoyl-L-alanine amid...

301

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1JWQ

23.9%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00015
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4048

47605856

UDP-N-acetylenolpyruvoylglucosamine redu...

301

Drug Target Homolog

Phase 1: October 2007

1HSK

39.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91198
(show subtarget assignments)

8

cloned

No

BAS5131

49188117

-

stage II sporulation protein

301

essential/virulence/pathogenesis / Essential proteins

Community Requests

3TUF

33.6%

Bacillus anthracis

IDP91793
(show subtarget assignments)

8

in_crystallization_trials

No

BAA03776

807707

mphA

macrolide 2'-phosphotransferase I [Esche...

301

other biological interest / Kinase

Community Requests

3TDV

21.3%

Escherichia coli

IDP01997
(show subtarget assignments)

1

cloned

No

STM4310

16767560

putative inner membrane protein [Salmone...

301

Conserved; Drug target functions

Phase 3: June 2008

3QQZ

29.6%

Salmonella enterica

Unknown function

General

IDP91864
(show subtarget assignments)

8

selected

No

ZP_08398653

332522401

transcriptional regulator, Cro/CI family...

301

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus porcinus

IDP91189
(show subtarget assignments)

1

in_pdb
4DE4
4DFB
4DFU

Yes

AAW59417

57918602

aph(2'')-Id

APH(2'')-Id [Enterococcus faecium]

301

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LZH

100%

Enterococcus faecium

IDP02406
(show subtarget assignments)

1

crystallized

No

GBAA2768

47528059

thioredoxin reductase, putative [Bacillu...

301

Conserved; Essential; Drug target functions

Phase 3: June 2008

3FBS

32.1%

Bacillus anthracis

Energy metabolism

Electron transport

IDP91794
(show subtarget assignments)

8

crystallized

No

BAA12910

1695688

mphB

macrolide 2'-phosphotransferase II [Esch...

302

other biological interest / Kinase

Community Requests

3TDW

18.5%

Escherichia coli

IDP00555
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3424

16123573

nadC

quinolinate phosphoribosyltransferase

302

Conserved Gene / Pathway

Phase 2: March 2008

1QAP

72.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00119
(show subtarget assignments)

1

purified

No

NT01ST0753

16763999

citE

citrate lyase beta chain

302

Essential

Phase 1: October 2007

1SGJ

32.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP91370
(show subtarget assignments)

8

expressed

No

VV1_2349

27365668

lactonizing lipase [Vibrio vulnificus CM...

302

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1EX9

55%

Vibrio vulnificus

IDP01040
(show subtarget assignments)

1

expressed

No

STM2935

16766241

cysD

sulfate adenylyltransferase subunit 2

302

Conserved Gene / Pathway

Phase 2: March 2008

1ZUN

75.2%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP02080
(show subtarget assignments)

1

in_pdb
3KZ2
3IH1

No

GBAA2350

47527645

yqiQ

carboxyvinyl-carboxyphosphonate phosphor...

302

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3IH1

100%

Bacillus anthracis

Central intermediary metabolism

Other

IDP02079
(show subtarget assignments)

1

expressed

No

Cj0173c

15791560

iron ABC transporter, ATP binding subuni...

302

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2D62

35.4%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00966
(show subtarget assignments)

1

expressed

No

STM1552

16764897

putative cytoplasmic protein

302

Essential Gene

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP04638
(show subtarget assignments)

1

expressed

No

FTT0372c

56707523

accD

Acetyl-CoA carboxylase beta subunit [Fra...

302

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

60.3%

Francisella tularensis

IDP05439
(show subtarget assignments)

1

soluble

No

lmo2499

16804537

-

hypothetical protein lmo2499 [Listeria m...

302

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4ECF

53.6%

Listeria monocytogenes

Transport and binding proteins: Anions

IDP91837
(show subtarget assignments)

8

selected

No

STRINF_00393

171778363

hypothetical protein STRINF_00393 [Strep...

302

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus infantarius

IDP01402
(show subtarget assignments)

1

cloned

No

VC0843

15640860

tagE protein

302

Drug Target Function

Phase 2: March 2008

3SLU

18.9%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP05522
(show subtarget assignments)

1

cloned

No

CD2240

126699857

nanA

N-acetylneuraminate lyase [Clostridium d...

302

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1F5Z

69.9%

Clostridium difficile

Central intermediary metabolism: Amino sugars

IDP91859
(show subtarget assignments)

8

cloned

No

SAK_0081

76788347

DNA-binding protein [Streptococcus agala...

302

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus agalactiae

IDP90719
(show subtarget assignments)

8

soluble

No

Cj0503c

15791865

hemH

ferrochelatase [Campylobacter jejuni sub...

303

Predicted Essential

Community Requests

2PO7

31%

Campylobacter jejuni

IDP00540
(show subtarget assignments)

1

purified

No

YPO2719

16122923

era

GTP-binding protein Era

303

Conserved Gene / Pathway

Phase 2: March 2008

1EGA

83.8%

Yersinia pestis

Cellular processes

Cell division

IDP91865
(show subtarget assignments)

8

selected

No

SpyM50034

139472918

DNA-binding protein [Streptococcus pyoge...

303

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus pyogenes

IDP91866
(show subtarget assignments)

8

expressed

No

SPy_0037

15674279

hypothetical protein SPy_0037 [Streptoco...

303

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus pyogenes

IDP91369
(show subtarget assignments)

8

in_pdb
4DB3

No

VV1_2570

326424042

N-acetyl-D-glucosamine kinase [Vibrio vu...

303

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

4DB3

100%

Vibrio vulnificus

IDP91866
(show subtarget assignments)

8

expressed

No

SPy_0037

15674279

hypothetical protein SPy_0037 [Streptoco...

303

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus pyogenes

IDP00445
(show subtarget assignments)

1

purified

No

YPO3843

16123978

xerC

site-specific tyrosine recombinase XerC ...

303

Conserved Gene / Pathway

Phase 2: March 2008

1A0P

35.6%

Yersinia pestis

DNA metabolism

DNA replication, recombination, and repair

IDP91860
(show subtarget assignments)

8

cloned

No

SAG0048

22536233

Cro/CI family transcriptional regulator ...

303

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus agalactiae

IDP92001
(show subtarget assignments)

8

selected

No

SpneCM_010100005688

298255086

hypothetical protein SpneCM_05688 [Strep...

303

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP91044
(show subtarget assignments)

8

in_crystallization_trials

No

EFA0002

110556113

vanY

vanY [Enterococcus faecalis]

303

drug resistance / A carboxypeptidase thought to be involved in breakdown of normal cell wall

Community Requests

Enterococcus faecalis

IDP91861
(show subtarget assignments)

8

selected

No

SDEG_0056

251781503

transcriptional regulator [Streptococcus...

303

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus dysgalactiae

IDP01392
(show subtarget assignments)

1

purified

No

VC0648

15640668

lipoprotein NlpI

303

Conserved Gene / Pathway

Phase 2: March 2008

1XNF

44.2%

Vibrio cholerae

Cell envelope

Other

IDP90986
(show subtarget assignments)

8

cloned

No

y0974

22124881

rdgC

recombination associated protein [Yersin...

303

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

2OWL

83.2%

Yersinia pestis

IDP02481
(show subtarget assignments)

1

cloned

No

Cj1139c

15792464

putative galactosyltransferase [Campylob...

303

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3BCV

24.1%

Campylobacter jejuni

DNA metabolism

DNA replication, recombination, and repair

IDP00307
(show subtarget assignments)

1

expressed

No

CBU_0142

29653500

lpxC

UDP-3-0-acyl N-acetylglucosamine deacety...

303

Drug Target Function

Phase 2: March 2008

2VES

65.7%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91568
(show subtarget assignments)

8

in_crystallization_trials

No

BAB35237

13361279

ECs1814

hypothetical protein [Escherichia coli O...

303

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP05312
(show subtarget assignments)

1

soluble

No

CD0895

126698472

metallo-beta-lactamase superfamily expor...

304

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Unknown function: General

IDP04123
(show subtarget assignments)

1

expressed

No

YPO2768

115348451

accD

acetyl-coenzyme A carboxylase carboxyl t...

304

conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

84.5%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02056
(show subtarget assignments)

1

expressed

No

CBU_0934

29541521

ABC transporter, ATP-binding protein [Co...

304

Conserved; Drug target functions

Phase 3: June 2008

1VPL

27.6%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP91832
(show subtarget assignments)

8

cloned

No

SMU.61

24378588

putative transcriptional regulator [Stre...

304

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus mutans

IDP90704
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0269c

15791640

ilvE

branched-chain amino acid aminotransfera...

304

Predicted Essential

Community Requests

3U0G

55.6%

Campylobacter jejuni

IDP05740
(show subtarget assignments)

1

cloned

No

CD2372

126699987

nadA

quinolinate synthetase [Clostridium diff...

304

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2QS0

42.1%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP01811
(show subtarget assignments)

1

expressed

No

FTT0908

56708009

parB

chromosome partition protein B [Francise...

304

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

23.7%

Francisella tularensis

Cellular processes

Cell division

IDP01787
(show subtarget assignments)

1

crystallized

No

STM0332

16763712

putative hydrolase/acyltransferase [Salm...

304

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3QYJ

47.4%

Salmonella enterica

Cellular processes

Detoxification

IDP04049
(show subtarget assignments)

1

soluble

No

VC1132

15641145

hisG

ATP phosphoribosyltransferase [Vibrio ch...

304

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1H3D

65.8%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP02775
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4028

47529321

pyrB

aspartate carbamoyltransferase catalytic...

304

Conserved; Drug target functions

Phase 3: June 2008

3R7D

61.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP05224
(show subtarget assignments)

1

cloned

No

VC_0595

9655026

glutamyl-tRNA synthetase-related protein...

304

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NZJ

55.3%

Vibrio cholerae

Unknown function: General

IDP90647
(show subtarget assignments)

8

cloned

No

VC2685

15642680

metF

5,10-methylenetetrahydrofolate reductase...

304

Predicted Essential

Community Requests

1ZP3

75.3%

Vibrio cholerae

IDP91862
(show subtarget assignments)

8

selected

No

SZO_00390

225867654

DNA-binding protein [Streptococcus equi ...

304

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus equi

IDP91832
(show subtarget assignments)

8

cloned

No

SMU.61

24378588

putative transcriptional regulator [Stre...

304

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus mutans

IDP00673
(show subtarget assignments)

1

expressed

No

SACOL1322

57286057

hydrolase, alpha/beta hydrolase fold fam...

304

Drug Target Function

Phase 2: March 2008

3HJU

24.7%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP91348
(show subtarget assignments)

8

soluble

No

VV1_3127

27366393

response regulator [Vibrio vulnificus CM...

304

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3BRE

32.7%

Vibrio vulnificus

IDP01207
(show subtarget assignments)

1

in_pdb
3R5X
3R23

Yes

BA_2610

39930865

D-alanine--D-alanine ligase (D-alanylala...

304

Conserved Gene / Pathway

Phase 2: March 2008

3R23

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05571
(show subtarget assignments)

1

soluble

No

BA_0168

30253677

conserved hypothetical protein [Bacillus...

304

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05464
(show subtarget assignments)

1

expressed

No

BA_1489

30255419

superoxide dismutase [Bacillus anthracis...

304

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1P7G

35.5%

Bacillus anthracis

Cellular processes: Detoxification

IDP05340
(show subtarget assignments)

1

in_pdb
3UUW

Yes

CD3450

126701073

putative oxidoreductase [Clostridium dif...

305

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

3UUW

100%

Clostridium difficile

Cellular processes: Pathogenesis

IDP91863
(show subtarget assignments)

8

selected

No

STP_0036

333904285

DNA-binding protein [Streptococcus parau...

305

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus parauberis

IDP04235
(show subtarget assignments)

1

cloned

No

CPF_0823

110800089

polysaccharide deacetylase family protei...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W3Z

32.1%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01840
(show subtarget assignments)

1

soluble

No

STM2861

16766167

sitA

putative periplasmic binding protein [Sa...

305

Conserved; Drug target functions

Phase 3: June 2008

1XVL

53.4%

Salmonella enterica

Cell envelope

Other

IDP90988
(show subtarget assignments)

8

expressed

No

y1189

22125092

gltI

glutamate and aspartate transporter subu...

305

other biological interest / -

Community Requests

2IA4

75.7%

Yersinia pestis

IDP90977
(show subtarget assignments)

8

soluble

No

y0320

22124237

oxyR

DNA-binding transcriptional regulator Ox...

305

other biological interest / important global regulator

Community Requests

1I6A

59.7%

Yersinia pestis

IDP05715
(show subtarget assignments)

1

purified

No

BA_0351

30253889

iron compound ABC transporter, iron comp...

305

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HXP

36.1%

Bacillus anthracis

Transport and binding proteins: Cations and iron carrying compounds

IDP00020
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5315

47605857

UDP-N-acetylenolpyruvoylglucosamine redu...

305

Drug Target Homolog

Phase 1: October 2007

1HSK

59.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01331
(show subtarget assignments)

1

purified

No

VC0589

15640610

ABC transporter, ATP-binding protein

305

Conserved Gene / Pathway

Phase 2: March 2008

2PCJ

28.9%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP04563
(show subtarget assignments)

1

soluble

No

CPF_1296

110798598

iron chelate ABC transporter solute-bind...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2CHU

27.9%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP90887
(show subtarget assignments)

8

cloned

No

YPO0104

16120451

menA

1,4-dihydroxy-2-naphthoate octaprenyltra...

305

Predicted Essential

Community Requests

Yersinia pestis

IDP90697
(show subtarget assignments)

8

cloned

No

Cj0098

15791486

fmt

methionyl-tRNA formyltransferase [Campyl...

305

Predicted Essential

Community Requests

3R8X

38%

Campylobacter jejuni

IDP01165
(show subtarget assignments)

1

expressed

No

BA_5650

30260099

ABC transporter, ATP-binding protein

305

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

30.8%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP91796
(show subtarget assignments)

8

in_crystallization_trials

No

AAB49832

1854639

gentamicin resistance protein [Enterococ...

306

other biological interest / Kinase

Community Requests

3TDV

100%

Enterococcus gallinarum

IDP90828
(show subtarget assignments)

8

in_pdb
3TPF

No

Cj0994c

15792321

argF

ornithine carbamoyltransferase [Campylob...

306

Predicted Essential

Community Requests

3TPF

100%

Campylobacter jejuni

IDP00575
(show subtarget assignments)

1

in_pdb
3V4Z

No

YPO0557

16120885

ddl

D-alanine--D-alanine ligase

306

Drug Target Function

Phase 2: March 2008

3V4Z

100%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02189
(show subtarget assignments)

1

cloned

No

YPO0269

16120608

type III secretion system protein [Yersi...

306

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking