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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 27 of 60, showing 100 records out of 5973 total, starting on record 2601
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP01965
(
show subtarget assignments
)
1
cloned
No
STM1786
16765127
hydrogenase-1 small subunit [Salmonella ...
372
Conserved; Drug target functions
Phase 3: June 2008
3UQY
80.9%
Salmonella enterica
Energy metabolism
Electron transport
IDP01963
(
show subtarget assignments
)
1
purified
No
STM1712
16765056
acnA
aconitate hydratase [Salmonella typhimur...
891
Conserved; Drug target functions
Phase 3: June 2008
3SN2
52.3%
Salmonella enterica
Energy metabolism
TCA cycle
IDP00961
(
show subtarget assignments
)
1
expressed
No
STM1385
16764735
ttrB
tetrathionate reductase complex subunit ...
250
Conserved Gene / Pathway
Phase 2: March 2008
2VPW
34.4%
Salmonella enterica
Energy metabolism
Electron transport
IDP01950
(
show subtarget assignments
)
1
expressed
No
STM1939
16765280
putative glucose-6-phosphate dehydrogena...
108
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Energy metabolism
Glycolysis/gluconeogenesis
IDP01939
(
show subtarget assignments
)
1
purified
No
STM4126
16767390
udhA
soluble pyridine nucleotide transhydroge...
466
Conserved; Drug target functions
Phase 3: June 2008
3URH
33%
Salmonella enterica
Energy metabolism
Pyruvate dehydrogenase
IDP01934
(
show subtarget assignments
)
1
soluble
No
GBAA0385
47525656
chitinase B [Bacillus anthracis str. 'Am...
674
Drug target motif; Drug target functions
Phase 3: June 2008
1ITX
37.4%
Bacillus anthracis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP01933
(
show subtarget assignments
)
1
soluble
No
FTT0061
56707240
atpH
F0F1 ATP synthase subunit delta [Francis...
174
Conserved; Drug target functions
Phase 3: June 2008
2WSS
28.2%
Francisella tularensis
Energy metabolism
ATP-proton motive force interconversion
IDP01930
(
show subtarget assignments
)
1
expressed
No
STM1578
16764922
narY
nitrate reductase 2 beta subunit [Salmon...
514
Conserved; Essential; Drug target functions
Phase 3: June 2008
1Q16
79%
Salmonella enterica
Energy metabolism
Anaerobic
IDP00948
(
show subtarget assignments
)
1
expressed
No
STM1060
16764419
putative iron-sulfur protein
369
Conserved Gene / Pathway
Phase 2: March 2008
1ROE
8.4%
Salmonella enterica
Energy metabolism
Electron transport
IDP01908
(
show subtarget assignments
)
1
cloned
No
STM1392
16764742
ssrA
sensor kinase [Salmonella typhimurium LT...
920
Conserved; Drug target functions
Phase 3: June 2008
2C2A
7.1%
Salmonella enterica
Energy metabolism
Anaerobic
IDP01909
(
show subtarget assignments
)
1
soluble
No
STM1536
16764881
putative hydrogenase maturation protease...
202
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
1CFZ
30.7%
Salmonella enterica
Energy metabolism
Aerobic
IDP04283
(
show subtarget assignments
)
1
expressed
No
YPO1971
218929083
hutG
putative N-formylglutamate amidohydrolas...
268
conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP01899
(
show subtarget assignments
)
1
expressed
No
STM2836
16766142
gutM
DNA-binding transcriptional activator Gu...
119
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Energy metabolism
Other
IDP01896
(
show subtarget assignments
)
1
soluble
No
STM0611
16763988
putative oxidoreductase protein [Salmone...
759
Conserved; Drug target functions
Phase 3: June 2008
1DMR
29.2%
Salmonella enterica
Energy metabolism
ATP-proton motive force interconversion
IDP01895
(
show subtarget assignments
)
1
soluble
No
STM1681
16765024
ycjG
putative chloromuconate cycloisomerase [...
321
Conserved; Drug target functions
Phase 3: June 2008
1JPD
85.4%
Salmonella enterica
Energy metabolism
Other
IDP00498
(
show subtarget assignments
)
1
cloned
No
YPO0166
16120509
putative glycosyl hydrolase
437
Drug Target Function
Phase 2: March 2008
1S6Y
52.6%
Yersinia pestis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP01891
(
show subtarget assignments
)
1
purified
No
STM3464
16766752
prkB
putative phosphoribulokinase [Salmonella...
289
Conserved; Drug target functions
Phase 3: June 2008
1A7J
50.5%
Salmonella enterica
Energy metabolism
Sugars
IDP01886
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM0085
16763475
yabF
glutathione-regulated potassium-efflux s...
176
Conserved; Drug target functions
Phase 3: June 2008
3EYW
87.5%
Salmonella enterica
Energy metabolism
Electron transport
IDP00930
(
show subtarget assignments
)
1
expressed
No
STM0612
16763989
putative hydrogenase protein
185
Conserved Gene / Pathway
Phase 2: March 2008
2VPW
30.3%
Salmonella enterica
Energy metabolism
Anaerobic
IDP01869
(
show subtarget assignments
)
1
purified
No
STM1467
16764813
manA
mannose-6-phosphate isomerase [Salmonell...
391
Conserved; Drug target functions
Phase 3: June 2008
2WFP
100%
Salmonella enterica
Energy metabolism
Sugars
IDP01867
(
show subtarget assignments
)
1
cloned
No
YPO0160
16120503
nirD
nitrite reductase small subunit [Yersini...
108
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
2JZA
71.3%
Yersinia pestis
Energy metabolism
Anaerobic
IDP01865
(
show subtarget assignments
)
1
in_pdb
3Q94
No
GBAA5580
47530901
fba-2
fructose-bisphosphate aldolase [Bacillus...
285
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3Q94
100%
Bacillus anthracis
Energy metabolism
Glycolysis/gluconeogenesis
IDP01863
(
show subtarget assignments
)
1
cloned
No
GBAA5548
47778410
atpG
F0F1 ATP synthase subunit gamma [Bacillu...
286
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
2QE7
58.7%
Bacillus anthracis
Energy metabolism
ATP-proton motive force interconversion
IDP01861
(
show subtarget assignments
)
1
in_pdb
3IGS
No
STM3337
16766632
nanE
N-acetylmannosamine-6-phosphate 2-epimer...
229
Conserved; Drug target functions
Phase 3: June 2008
3IGS
99.6%
Salmonella enterica
Energy metabolism
Sugars
IDP04373
(
show subtarget assignments
)
1
cloned
No
YPO3097
218930139
manB
phosphomannomutase [Yersinia pestis CO92...
457
drug target; virulence factor; putative drug target function;
Phase 4: April 2009
3UW2
37.8%
Yersinia pestis
Energy metabolism
Sugars
IDP01857
(
show subtarget assignments
)
1
soluble
No
FTT1034c
56708121
ndh
NADH dehydrogenase [Francisella tularens...
420
Drug Target
Phase 3: June 2008
1XHC
21%
Francisella tularensis
Energy metabolism
Electron transport
IDP00484
(
show subtarget assignments
)
1
cloned
No
YPO1417
16121697
putative iron-sulfur binding protein
370
Conserved Gene / Pathway
Phase 2: March 2008
2PIA
7%
Yersinia pestis
Energy metabolism
Electron transport
IDP01841
(
show subtarget assignments
)
1
purified
No
STM2549
16765869
asrB
anaerobic sulfite reductase subunit B [S...
272
Conserved; Drug target functions
Phase 3: June 2008
1KRH
18.8%
Salmonella enterica
Energy metabolism
Anaerobic
IDP01834
(
show subtarget assignments
)
1
soluble
No
STM2345
16765672
putative transcriptional regulator [Salm...
339
Conserved; Drug target functions
Phase 3: June 2008
3H5O
33.9%
Salmonella enterica
Energy metabolism
Entner-Doudoroff
IDP01832
(
show subtarget assignments
)
1
expressed
No
GBAA5547
47530867
atpD
F0F1 ATP synthase subunit beta [Bacillus...
469
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1SKY
86.4%
Bacillus anthracis
Energy metabolism
ATP-proton motive force interconversion
IDP01830
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0407
56707556
gcvT
glycine cleavage system aminomethyltrans...
358
Drug Target
Phase 3: June 2008
1VLO
47.9%
Francisella tularensis
Energy metabolism
Amino acids and amines
IDP01824
(
show subtarget assignments
)
1
cloned
No
STM3197
16766497
glgS
glycogen synthesis protein GlgS [Salmone...
69
Conserved; Drug target functions
Phase 3: June 2008
1RRZ
73.9%
Salmonella enterica
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP00201
(
show subtarget assignments
)
1
expressed
No
YPO1476
16121751
-
hypothetical protein
727
Virulence
Phase 1: October 2007
Yersinia pestis
Energy metabolism
Photosynthesis
IDP01821
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA5549
47530869
atpA
F0F1 ATP synthase subunit alpha [Bacillu...
502
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1SKY
84.5%
Bacillus anthracis
Energy metabolism
ATP-proton motive force interconversion
IDP00200
(
show subtarget assignments
)
1
expressed
No
YPO1473
16121748
-
hypothetical protein
766
Virulence
Phase 1: October 2007
Yersinia pestis
Energy metabolism
Glycolysis/gluconeogenesis
IDP00891
(
show subtarget assignments
)
0
work_stopped
No
STM3816
16767101
ccmD
heme exporter protein C
70
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Energy metabolism
Electron transport
IDP01812
(
show subtarget assignments
)
1
cloned
No
FTT1764c
56708759
ferredoxin [Francisella tularensis subsp...
107
Conserved; Drug target functions
Phase 3: June 2008
1A6L
64.5%
Francisella tularensis
Energy metabolism
Electron transport
IDP01806
(
show subtarget assignments
)
1
soluble
No
lmo1883
16803922
hypothetical protein lmo1883 [Listeria m...
352
Presence of Protease Motifs; Predicted involvement in glycosyl group metabolism
Phase 3: June 2008
3IAN
53.1%
Listeria monocytogenes
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP01802
(
show subtarget assignments
)
1
crystallized
No
FTT0062
56707241
atpA
F0F1 ATP synthase subunit alpha [Francis...
513
Conserved; Drug target functions
Phase 3: June 2008
3OAA
71%
Francisella tularensis
Energy metabolism
ATP-proton motive force interconversion
IDP01801
(
show subtarget assignments
)
1
in_pdb
3MSZ
3LGC
No
FTT0533c
56707666
grxA
glutaredoxin 1 [Francisella tularensis s...
86
Drug Target
Phase 3: June 2008
3LGC
100%
Francisella tularensis
Energy metabolism
Electron transport
IDP00470
(
show subtarget assignments
)
1
expressed
No
YPO0367
16120702
putative iron-sulfur cluster-binding pro...
411
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Energy metabolism
Electron transport
IDP01794
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA1026
47526305
glpK
glycerol kinase [Bacillus anthracis str....
496
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3G25
75%
Bacillus anthracis
Energy metabolism
Other
IDP01793
(
show subtarget assignments
)
1
in_pdb
3QDN
No
STM0504
16763884
ybbN
putative thioredoxin protein [Salmonella...
284
Conserved; Drug target functions
Phase 3: June 2008
3QDN
100%
Salmonella enterica
Energy metabolism
Electron transport
IDP01792
(
show subtarget assignments
)
1
expressed
No
GBAA0866
47777865
alsS
acetolactate synthase [Bacillus anthraci...
562
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1OZF
50.7%
Bacillus anthracis
Energy metabolism
Fermentation
IDP00096
(
show subtarget assignments
)
1
in_crystallization_trials
No
NTL02SF1070
30040886
ycfO
hypothetical protein S1191
341
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
1TR9
55.7%
Shigella flexneri
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP01784
(
show subtarget assignments
)
1
expressed
No
STM1383
16764733
ttrA
tetrathionate reductase complex subunit ...
1020
Conserved; Drug target functions
Phase 3: June 2008
2IVF
18.1%
Salmonella enterica
Energy metabolism
Electron transport
IDP01782
(
show subtarget assignments
)
1
expressed
No
GBAA0752
47526035
scrK
fructokinase [Bacillus anthracis str. 'A...
313
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3EWM
33.8%
Bacillus anthracis
Energy metabolism
Sugars
IDP00878
(
show subtarget assignments
)
1
expressed
No
STM4306
16767556
putative anaerobic dimethylsulfoxide red...
208
Conserved Gene / Pathway
Phase 2: March 2008
2VPW
29.3%
Salmonella enterica
Energy metabolism
Anaerobic
IDP00463
(
show subtarget assignments
)
1
purified
No
YPO1615
16121883
beta-hexosaminidase
343
Drug Target Function
Phase 2: March 2008
2OXN
55.1%
Yersinia pestis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP00862
(
show subtarget assignments
)
1
cloned
No
STM2251
16765579
ccmD
heme exporter protein C
70
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Energy metabolism
Electron transport
IDP01739
(
show subtarget assignments
)
1
in_pdb
3KHY
No
FTT1753
56708751
tdcD
propionate kinase [Francisella tularensi...
384
Conserved; Drug target functions
Phase 3: June 2008
3KHY
100%
Francisella tularensis
Energy metabolism
Fermentation
IDP00453
(
show subtarget assignments
)
1
purified
No
YPO2969
16123150
putative iron-sulphur protein
189
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Energy metabolism
Electron transport
IDP00450
(
show subtarget assignments
)
1
cloned
No
YPCD1.40
16082728
yscN
type III secretion system ATPase
439
Virulence Associated Factor
Phase 2: March 2008
2DPY
42.8%
Yersinia pestis
Energy metabolism
ATP-proton motive force interconversion
IDP04361
(
show subtarget assignments
)
1
soluble
No
YPO2803
218929869
bglB
putative beta-glucosidase [Yersinia pest...
793
drug target; putative drug target function;
Phase 4: April 2009
2X40
37.3%
Yersinia pestis
Energy metabolism
Sugars
IDP01719
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA5560
47530880
ribose-5-phosphate isomerase B [Bacillus...
147
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3HE8
55.1%
Bacillus anthracis
Energy metabolism
Sugars
IDP01710
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA0371
47525642
glycosyl hydrolase family protein [Bacil...
554
Conserved; Drug target functions
Phase 3: June 2008
2ZE0
67%
Bacillus anthracis
Energy metabolism
Sugars
IDP04235
(
show subtarget assignments
)
1
cloned
No
CPF_0823
110800089
polysaccharide deacetylase family protei...
305
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2W3Z
32.1%
Clostridium perfringens
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP01694
(
show subtarget assignments
)
1
purified
No
YPO3335
16123488
fumA
fumarate hydratase, class I [Yersinia pe...
547
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
2ISB
10.1%
Yersinia pestis
Energy metabolism
TCA cycle
IDP00831
(
show subtarget assignments
)
0
work_stopped
No
SACOL2545
57285227
sdaAB
L-serine dehydratase, iron-sulfur-depend...
226
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
Energy metabolism
Amino acids and amines
IDP00830
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL2544
57285226
sdaAA
L-serine dehydratase, iron-sulfur-depend...
299
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
Energy metabolism
Amino acids and amines
IDP00829
(
show subtarget assignments
)
1
purified
No
SACOL2515
57285199
gntK
gluconokinase
517
Drug Target Function
Phase 2: March 2008
3GBT
39.3%
Staphylococcus aureus
Energy metabolism
Sugars
IDP01679
(
show subtarget assignments
)
1
cloned
No
FTT0738
56707853
yjeF
carbohydrate kinase family protein (YjeF...
514
Conserved; Drug target functions
Phase 3: June 2008
2AX3
28%
Francisella tularensis
Energy metabolism
Sugars
IDP00817
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL2098
57286314
atpH
ATP synthase F1, delta subunit
179
Drug Target Function
Phase 2: March 2008
2WSS
21.2%
Staphylococcus aureus
Energy metabolism
ATP-proton motive force interconversion
IDP01650
(
show subtarget assignments
)
1
in_pdb
3IFS
No
GBAA5130
47530435
pgi
glucose-6-phosphate isomerase [Bacillus ...
450
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3IFS
100%
Bacillus anthracis
Energy metabolism
Glycolysis/gluconeogenesis
IDP01646
(
show subtarget assignments
)
1
soluble
No
GBAA5119
47530423
glgP
glycogen phosphorylase [Bacillus anthrac...
802
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1AXR
46.5%
Bacillus anthracis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP01635
(
show subtarget assignments
)
1
soluble
No
GBAA4844
47530139
pfkA
6-phosphofructokinase [Bacillus anthraci...
319
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3U39
86.5%
Bacillus anthracis
Energy metabolism
Glycolysis/gluconeogenesis
IDP04721
(
show subtarget assignments
)
1
expressed
No
YPO1289
115347051
conserved hypothetical protein [Yersinia...
380
conserved gene; putative drug target function;
Phase 4: April 2009
2Q18
16.8%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP01623
(
show subtarget assignments
)
1
cloned
No
GBAA5019
47530321
pckA
phosphoenolpyruvate carboxykinase [Bacil...
528
Conserved; Essential; Drug target functions
Phase 3: June 2008
1J3B
52.8%
Bacillus anthracis
Energy metabolism
Glycolysis/gluconeogenesis
IDP00790
(
show subtarget assignments
)
1
expressed
No
SACOL1103
57285889
pdhB
pyruvate dehydrogenase complex E1 compon...
325
Drug Target Function
Phase 2: March 2008
3DUF
75.7%
Staphylococcus aureus
Energy metabolism
Pyruvate dehydrogenase
IDP01606
(
show subtarget assignments
)
1
cloned
No
GBAA4968
47530266
gdH
glucose-1-dehydrogenase [Bacillus anthra...
261
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
1GEE
87.7%
Bacillus anthracis
Energy metabolism
Other
IDP04722
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1357
115347116
ltaA
L-allo-threonine aldolase [Yersinia pest...
339
conserved gene; putative drug target function;
Phase 4: April 2009
1LW4
46.5%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP01518
(
show subtarget assignments
)
1
purified
No
VC1512
15641521
formate dehydrogenase, iron-sulfur subun...
202
Conserved Gene / Pathway
Phase 2: March 2008
1KQF
29%
Vibrio cholerae
Energy metabolism
Anaerobic
IDP01517
(
show subtarget assignments
)
1
expressed
No
VC1254
15641267
iron-sulfur cluster-binding protein, put...
92
Conserved Gene / Pathway
Phase 2: March 2008
1AWD
26.1%
Vibrio cholerae
Energy metabolism
Electron transport
IDP00416
(
show subtarget assignments
)
1
expressed
No
YPO1212
16121503
2Fe-2S ferredoxin YfaE
85
Conserved Gene / Pathway
Phase 2: March 2008
3AV8
33.3%
Yersinia pestis
Energy metabolism
Electron transport
IDP00757
(
show subtarget assignments
)
1
soluble
No
SACOL0135
57285338
alcohol dehydrogenase, iron-containing
869
Conserved Gene / Pathway
Phase 2: March 2008
3MY7
25.3%
Staphylococcus aureus
Energy metabolism
Fermentation
IDP01492
(
show subtarget assignments
)
1
purified
No
VCA0702
15601458
iron-containing alcohol dehydrogenase
382
Conserved Gene / Pathway
Phase 2: March 2008
1OJ7
50.8%
Vibrio cholerae
Energy metabolism
Fermentation
IDP04685
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA3438
47528724
alcohol dehydrogenase, zinc-containing [...
335
virulence factor; putative drug target function;
Phase 4: April 2009
3GAZ
37.3%
Bacillus anthracis
Energy metabolism
Fermentation
IDP04683
(
show subtarget assignments
)
1
expressed
No
GBAA3269
47528557
iron-sulfur cluster-binding protein [Bac...
470
virulence factor; putative drug target function;
Phase 4: April 2009
Bacillus anthracis
Energy metabolism
Electron transport
IDP01486
(
show subtarget assignments
)
1
in_pdb
3IEB
3JR2
No
VCA0242
15601010
ulaD
3-keto-L-gulonate-6-phosphate decarboxyl...
215
Conserved Gene / Pathway
Phase 2: March 2008
3IEB
100%
Vibrio cholerae
Energy metabolism
Sugars
IDP00751
(
show subtarget assignments
)
8
purified
No
SACOL2117
57286333
fbaA
fructose-bisphosphate aldolase
286
Drug Target Function
Community Requests
3Q94
75.9%
Staphylococcus aureus
Energy metabolism
Glycolysis/gluconeogenesis
IDP04681
(
show subtarget assignments
)
1
soluble
No
GBAA3131
47528422
adhB
alcohol dehydrogenase, zinc-containing [...
377
virulence factor; putative drug target function;
Phase 4: April 2009
1KOL
31.9%
Bacillus anthracis
Energy metabolism
Fermentation
IDP00411
(
show subtarget assignments
)
1
purified
No
YPO0161
16120504
nirB
nitrite reductase
848
Drug Target Function
Phase 2: March 2008
1D7Y
13.6%
Yersinia pestis
Energy metabolism
Electron transport
IDP04050
(
show subtarget assignments
)
1
purified
No
YPO1765
218928887
hpaF
5-carboxymethyl-2-hydroxymuconate delta-...
132
conserved gene; putative drug target function;
Phase 4: April 2009
1OTG
67.4%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP01474
(
show subtarget assignments
)
1
expressed
No
VC2657
15642652
fumarate reductase iron-sulfur subunit
252
Conserved Gene / Pathway
Phase 2: March 2008
1KF6
69%
Vibrio cholerae
Energy metabolism
Anaerobic
IDP01471
(
show subtarget assignments
)
1
purified
No
VC2613
15642608
phosphoribulokinase
289
Conserved Gene / Pathway
Phase 2: March 2008
1A7J
51.6%
Vibrio cholerae
Energy metabolism
Sugars
IDP04037
(
show subtarget assignments
)
1
in_pdb
3S52
No
YPO2082
115347800
putative fumarylacetoacetate hydrolase f...
218
putative drug target function;
Phase 4: April 2009
3S52
100%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP00744
(
show subtarget assignments
)
1
soluble
No
SACOL1563
57284661
lpdA
2-oxoisovalerate dehydrogenase, E3 compo...
473
Drug Target Function
Phase 2: March 2008
3URH
37%
Staphylococcus aureus
Energy metabolism
Amino acids and amines
IDP00743
(
show subtarget assignments
)
1
in_pdb
3G25
3GE1
Yes
SACOL1320
57286055
glpK
glycerol kinase
498
Drug Target Function
Phase 2: March 2008
3G25
100%
Staphylococcus aureus
Energy metabolism
Other
IDP00740
(
show subtarget assignments
)
1
cloned
No
SACOL1105
57285891
pdhD
dihydrolipoamide dehydrogenase
468
Drug Target Function
Phase 2: March 2008
1EBD
70.9%
Staphylococcus aureus
Energy metabolism
Pyruvate dehydrogenase
IDP01459
(
show subtarget assignments
)
1
soluble
No
VC2420
161581987
flavodoxin
172
Conserved Gene / Pathway
Phase 2: March 2008
1AG9
45.3%
Vibrio cholerae
Energy metabolism
Electron transport
IDP04008
(
show subtarget assignments
)
1
cloned
No
YPO0906
218928079
gcsH
glycine cleavage system protein H [Yersi...
128
conserved gene; putative drug target function;
Phase 4: April 2009
3A7A
75%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP00736
(
show subtarget assignments
)
1
in_pdb
3FF1
No
SACOL0966
57285840
pgi
glucose-6-phosphate isomerase
443
Drug Target Function
Phase 2: March 2008
3FF1
100%
Staphylococcus aureus
Energy metabolism
Glycolysis/gluconeogenesis
IDP00734
(
show subtarget assignments
)
1
purified
No
SACOL0841
57284303
pgm
phosphoglyceromutase
505
Drug Target Function
Phase 2: March 2008
1EJJ
62%
Staphylococcus aureus
Energy metabolism
Glycolysis/gluconeogenesis
IDP02829
(
show subtarget assignments
)
1
cloned
No
GBAA4382
47529677
bfmbB
branched-chain alpha-keto acid dehydroge...
439
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3DUF
38.4%
Bacillus anthracis
Energy metabolism
Amino acids and amines
IDP01446
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC2099
15642099
flavodoxin FldA
175
Conserved Gene / Pathway
Phase 2: March 2008
1AG9
75.4%
Vibrio cholerae
Energy metabolism
Electron transport
IDP01445
(
show subtarget assignments
)
1
soluble
No
VC2088
15642088
sdhB
succinate dehydrogenase iron-sulfur subu...
236
Conserved Gene / Pathway
Phase 2: March 2008
1NEK
77.2%
Vibrio cholerae
Energy metabolism
TCA cycle
IDP02814
(
show subtarget assignments
)
1
cloned
No
FTT0709
56707828
eno
enolase (2-phosphoglycerate dehydratase)...
456
Conserved; Drug target functions
Phase 3: June 2008
1IYX
60.5%
Francisella tularensis
Energy metabolism
Glycolysis/gluconeogenesis
IDP02812
(
show subtarget assignments
)
1
cloned
No
FTT1484c
56708523
aceF
dihydrolipoamide acetyltransferase [Fran...
631
Conserved; Drug target functions
Phase 3: June 2008
3DUF
26%
Francisella tularensis
Energy metabolism
Pyruvate dehydrogenase
IDP04363
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO3500
115349125
mrsA
probable phosphoglucomutase/phosphomanno...
446
drug target; putative drug target function;
Phase 4: April 2009
3PDK
46.4%
Yersinia pestis
Energy metabolism
Sugars
IDP02779
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT1405c
56708453
gloB
hydroxyacylglutathione hydrolase [Franci...
252
Conserved; Drug target functions
Phase 3: June 2008
2QED
34.1%
Francisella tularensis
Energy metabolism
Other
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