Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04096 (show subtarget assignments)	1	purified	No	YPO2010	115347732	ychF	conserved hypothetical protein [Yersinia...	363	drug target; virulence factor; conserved gene;	Phase 4: April 2009	1JAL	79.6%	Yersinia pestis	Unknown function	General

IDP04097 (show subtarget assignments)	1	cloned	No	CPF_2217	110801384	yunB	sporulation protein YunB [Clostridium pe...	229	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04098 (show subtarget assignments)	1	cloned	No	YPCD1.50	5832470	YPCD1.50	hypothetical protein YPCD1.50 [Yersinia ...	32	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04099 (show subtarget assignments)	1	expressed	No	VC1027	9655490		molybdenum cofactor biosynthesis protein...	81	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1FM0	70.4%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP04100 (show subtarget assignments)	1	cloned	No	YPCD1.45	16082733	yscS	needle complex export protein [Yersinia ...	88	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04101 (show subtarget assignments)	1	purified	No	CPF_2392	110799105	minE	cell division topological specificity fa...	90	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Cell division

IDP04102 (show subtarget assignments)	1	cloned	No	YPO2227	218929324	pyrF	orotidine 5'-phosphate decarboxylase [Ye...	245	conserved gene; putative drug target function;	Phase 4: April 2009	1EIX	72.2%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04103 (show subtarget assignments)	1	cloned	No	YPO2280	218929372		putative phage-related secreted protein ...	414	putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04104 (show subtarget assignments)	1	expressed	No	YPO2309	115348012	rstB	two-component regulatory system, sensor ...	425	putative drug target function;	Phase 4: April 2009	2C2A	16.7%	Yersinia pestis	Regulatory functions	Other

IDP04105 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2391	115348093	ribC	riboflavin synthase alpha chain [Yersini...	218	conserved gene; putative drug target function;	Phase 4: April 2009	1I8D	74.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP04106 (show subtarget assignments)	1	cloned	No	BAS0124	49183158		30S ribosomal protein S8 [Bacillus anthr...	132	Proposed to be essential proteins	Phase 4: April 2009	1SEI	85.6%	Bacillus anthracis

IDP04107 (show subtarget assignments)	1	purified	No	BAS0120	49183154		50S ribosomal protein L14 [Bacillus anth...	122	Proposed to be essential proteins	Phase 4: April 2009	1C04	86.9%	Bacillus anthracis

IDP04108 (show subtarget assignments)	1	expressed	No	YPO0507	115346316		conserved hypothetical protein [Yersinia...	782	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2P5Z	13.7%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04109 (show subtarget assignments)	1	crystallized	No	GBAA3100	47528393		copper homeostasis protein CutC, putativ...	225	virulence factor; putative drug target function;	Phase 4: April 2009	2BDQ	30.7%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP04110 (show subtarget assignments)	1	expressed	No	YPO2440	218929529	yfeB	ATP-binding transport protein [Yersinia ...	296	virulence factor; conserved gene;	Phase 4: April 2009	3GFO	26.4%	Yersinia pestis	Unknown function	General

IDP04111 (show subtarget assignments)	1	cloned	No	YPO2524	115348222	menC	putative O-succinylbenzoate-CoA synthase...	323	conserved gene; putative drug target function;	Phase 4: April 2009	3GC2	66.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04112 (show subtarget assignments)	1	cloned	No	YPO2626	115348318	nagA	putative N-acetylglucosamine-6-phosphate...	381	drug target; putative drug target function;	Phase 4: April 2009	1YMY	75.1%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP04113 (show subtarget assignments)	1	selected	No	YPO2627	115348319	glmD	putative glucosamine-6-phosphate isomera...	266	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CD5	85.7%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP04114 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1611	115347358		conserved hypothetical protein [Yersinia...	117	drug target; conserved gene;	Phase 4: April 2009	3N1S	84.6%	Yersinia pestis	Unknown function	General

IDP04115 (show subtarget assignments)	1	expressed	No	STM2352_1_235	16765679	hisM	histidine/lysine/arginine/ornithine tran...	235	Salmonella essential protein	Phase 4: April 2009	3DHW	23.8%	Salmonella enterica

IDP04116 (show subtarget assignments)	1	expressed	No	Z5122	15804232	sepZ	hypothetical protein Z5122 [Escherichia ...	99	Effector protein	Phase 4: April 2009			Escherichia coli

IDP04117 (show subtarget assignments)	8	selected	No	CAC05825	12329094	spa13	spa13, component of the Mxi-Spa secretio...	112	Shigella effector protein	Community Requests			Shigella flexneri

IDP04118 (show subtarget assignments)	1	cloned	No	YPCD1.22c	5832443	YPCD1.22c	hypothetical protein YPCD1.22c [Yersinia...	129	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04119 (show subtarget assignments)	1	crystallized	No	BAS0131	49183165		adenylate kinase [Bacillus anthracis str...	216	Proposed to be essential proteins	Phase 4: April 2009	1ZIN	74.1%	Bacillus anthracis

IDP04120 (show subtarget assignments)	1	soluble	No	BAS1475	49184492		xanthine phosphoribosyltransferase [Baci...	197	Proposed to be essential proteins	Phase 4: April 2009	1Y0B	65%	Bacillus anthracis

IDP04121 (show subtarget assignments)	1	cloned	No	YPO2725	115348408		conserved hypothetical protein [Yersinia...	921	virulence factor; putative drug target function;	Phase 4: April 2009	2P5Z	12.6%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04122 (show subtarget assignments)	1	in_pdb 3OJC	Yes	YPO2758	115348441		putative aspartate/glutamate racemase [Y...	231	conserved gene; putative drug target function;	Phase 4: April 2009	3OJC	100%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP04123 (show subtarget assignments)	1	expressed	No	YPO2768	115348451	accD	acetyl-coenzyme A carboxylase carboxyl t...	304	conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	84.5%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04124 (show subtarget assignments)	1	crystallized	No	YPO2828	218929893	purI	phosphoribosylaminoimidazole synthetase ...	347	conserved gene; putative drug target function;	Phase 4: April 2009	1CLI	81.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04125 (show subtarget assignments)	1	cloned	No	YPO2847	115348521	yegM	putitive HlyD family secretion protein [...	444	conserved gene; putative drug target function;	Phase 4: April 2009	3FPP	21.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04126 (show subtarget assignments)	1	cloned	No	YPO2871	115348542	guaB	inosine-5'-monophosphate dehydrogenase [...	487	conserved gene; putative drug target function;	Phase 4: April 2009	1ZFJ	56.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04127 (show subtarget assignments)	1	crystallized	No	YPO2889	115348559	pepB	peptidase B [Yersinia pestis CO92]	432	drug target; putative drug target function;	Phase 4: April 2009	1BLL	32.9%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04128 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2899	115348569	suhB	putative inositol monophosphatase family...	267	putative drug target function;	Phase 4: April 2009	2QFL	83.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04129 (show subtarget assignments)	1	expressed	No	YPO0764	115346558		conserved hypothetical protein [Yersinia...	741	virulence factor; putative drug target function;	Phase 4: April 2009	2P5Z	16.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04130 (show subtarget assignments)	1	cloned	No	YPO2938	115348602		conserved hypothetical protein [Yersinia...	500	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04131 (show subtarget assignments)	1	cloned	No	YPO2947	115348609		conserved hypothetical protein [Yersinia...	626	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04132 (show subtarget assignments)	1	cloned	No	YPO2997	218930046		putative two-component system sensor kin...	449	putative drug target function;	Phase 4: April 2009	3JZ3	15.4%	Yersinia pestis	Regulatory functions	Other

IDP04133 (show subtarget assignments)	1	cloned	No	CPF_1195	110798868	hpkA	sensor histidine kinase [Clostridium per...	287	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	25.8%	Clostridium perfringens	Regulatory functions	Other

IDP04134 (show subtarget assignments)	1	expressed	No	FTT0666c	56707787		methylpurine-DNA glycosylase family prot...	193	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BNK	39.7%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP04135 (show subtarget assignments)	1	cloned	No	BAS4470	49187465		50S ribosomal protein L35 [Bacillus anth...	66	Proposed to be essential proteins	Phase 4: April 2009	1VS6	48.5%	Bacillus anthracis

IDP04136 (show subtarget assignments)	1	diffraction	No	GBAA4258	47529551		5-methylthio-3-oxo-1-penten-1,2-diol dio...	170	putative drug target function;	Phase 4: April 2009	1ZRR	31.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP04137 (show subtarget assignments)	1	soluble	No	BAS0134	49183168		50S ribosomal protein L36 [Bacillus anth...	37	Proposed to be essential proteins	Phase 4: April 2009	1DFE	81.1%	Bacillus anthracis

IDP04138 (show subtarget assignments)	1	expressed	No	YPO0811	218927991		general secretion pathway protein I [Yer...	114	putative drug target function;	Phase 4: April 2009	3CI0	19.3%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04139 (show subtarget assignments)	1	soluble	No	YPO2999	218930048		putative HlyD family secretion protein [...	401	putative drug target function;	Phase 4: April 2009	4DK0	35.9%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04140 (show subtarget assignments)	1	cloned	No	YPO3116	115348760	ascD	cdp-6-deoxy-delta-3,4-glucoseen reductas...	329	virulence factor; putative drug target function;	Phase 4: April 2009	1KRH	26.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04141 (show subtarget assignments)	1	in_pdb 3V4H	Yes	YPO2937	115348601		conserved hypothetical protein [Yersinia...	161	virulence factor; conserved gene;	Phase 4: April 2009	3V4H	100%	Yersinia pestis	Hypothetical proteins	Conserved

IDP04142 (show subtarget assignments)	1	purified	No	YPO3191	218930221	tgt	queuine tRNA-ribosyltransferase [Yersini...	374	drug target; putative drug target function;	Phase 4: April 2009	1OZM	55.1%	Yersinia pestis	Protein synthesis	tRNA and rRNA base modification

IDP04143 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3275	115348911	clpB	Clp ATPase [Yersinia pestis CO92]	857	drug target; putative drug target function;	Phase 4: April 2009	1QVR	57.1%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04144 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3337	218930358	map	methionine aminopeptidase [Yersinia pest...	261	drug target; virulence factor; putative drug target function;	Community Interest	1C21	55.2%	Yersinia pestis	Protein fate	Protein modification and repair

IDP04145 (show subtarget assignments)	1	expressed	No	YPO3422	115349050	ampE	putative membrane-bound sensory transduc...	284	conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cellular processes	Toxin production and resistance

IDP04146 (show subtarget assignments)	1	expressed	No	YPO2147	218929248	dadA	D-amino acid dehydrogenase small subunit...	434	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1PJ5	19.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04147 (show subtarget assignments)	1	expressed	No	YPO3427	115349055	hofC	putative type II secretion system protei...	399	conserved gene; putative drug target function;	Phase 4: April 2009	2VMA	9.8%	Yersinia pestis	Energy metabolism	Electron transport

IDP04148 (show subtarget assignments)	1	expressed	No	YPO3508	115349133	basS	two-component system sensor protein [Yer...	355	conserved gene; putative drug target function;	Phase 4: April 2009	3JZ3	23.1%	Yersinia pestis	Regulatory functions	Other

IDP04149 (show subtarget assignments)	1	expressed	No	YPO3706	115349323		conserved hypothetical protein [Yersinia...	493	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04150 (show subtarget assignments)	1	purified	No	YPO3707	115349324		conserved hypothetical protein [Yersinia...	165	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04151 (show subtarget assignments)	1	cloned	No	YPO3864	218930867	nfrC	UDP-N-acetylglucosamine 2-epimerase [Yer...	376	drug target; putative drug target function;	Phase 4: April 2009	1F6D	78.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04152 (show subtarget assignments)	1	cloned	No	YPO3919	218930919		HlyD family secretion protein [Yersinia ...	442	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04153 (show subtarget assignments)	1	cloned	No	YPO3975	218930970	opdA	oligopeptidase A [Yersinia pestis CO92]	680	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1S4B	30.7%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04154 (show subtarget assignments)	1	cloned	No	YPO4017	218931008	hutU	urocanate hydratase [Yersinia pestis CO9...	563	conserved gene; putative drug target function;	Phase 4: April 2009	1UWL	86.3%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04155 (show subtarget assignments)	1	cloned	No	VC0547	9654975		aspartokinase, alpha and beta subunits [...	395	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3L76	39.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP04156 (show subtarget assignments)	1	expressed	No	VC0681	9655120		riboflavin kinase/FMN adenylyltransferas...	322	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1MRZ	32.3%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP04157 (show subtarget assignments)	1	soluble	No	VC1085	15641098		sensor histidine kinase [Vibrio cholerae...	434	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.1%	Vibrio cholerae	Regulatory functions	Other

IDP04158 (show subtarget assignments)	1	expressed	No	VC1088	15641101		sensor histidine kinase [Vibrio cholerae...	534	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3D36	13.5%	Vibrio cholerae	Regulatory functions	Other

IDP04159 (show subtarget assignments)	1	cloned	No	VC1134	15641147		histidinol-phosphate aminotransferase [V...	346	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1FG3	59.8%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP04160 (show subtarget assignments)	1	in_pdb 3NAV	No	VC1169	9655645		tryptophan synthase, alpha subunit [Vibr...	268	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3NAV	100%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP04161 (show subtarget assignments)	1	cloned	No	VC1172	9655648		anthranilate phosphoribosyltransferase [...	353	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KGZ	59.5%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP04162 (show subtarget assignments)	1	expressed	No	VC1190	15641203	hemH	phosphoribosylaminoimidazole-succinocarb...	405	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3R9R	25.4%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04163 (show subtarget assignments)	1	expressed	No	VC1349	15641361		sensory box sensor histidine kinase/resp...	1331	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	6.5%	Vibrio cholerae	Regulatory functions	Other

IDP04164 (show subtarget assignments)	1	cloned	No	VC1445	15641456		sensor histidine kinase/response regulat...	572	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	14.5%	Vibrio cholerae	Regulatory functions	Other

IDP04165 (show subtarget assignments)	1	expressed	No	VC1521	15641529		sensor histidine kinase [Vibrio cholerae...	677	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	11.7%	Vibrio cholerae	Regulatory functions	Other

IDP04166 (show subtarget assignments)	1	cloned	No	VC1653	15641658		sensory box sensor histidine kinase/resp...	1146	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	6.6%	Vibrio cholerae	Regulatory functions	Other

IDP04167 (show subtarget assignments)	1	cloned	No	VC1977	9656518		aspartate aminotransferase, putative [Vi...	404	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XI9	40.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP04168 (show subtarget assignments)	1	purified	No	VC2142	15642141		flagellin [Vibrio cholerae O1 biovar elt...	376	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3K8V	37.5%	Vibrio cholerae	Cellular processes	Chemotaxis and motility

IDP04169 (show subtarget assignments)	1	in_crystallization_trials	No	VC2180	15642179	hemA	glutamyl-tRNA reductase [Vibrio cholerae...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GPJ	35.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04170 (show subtarget assignments)	1	cloned	No	VC2183	15642182		ribose-phosphate pyrophosphokinase [Vibr...	314	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3DAH	63.7%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04171 (show subtarget assignments)	1	cloned	No	VC2244	15642242		acetyl-CoA carboxylase carboxyltransfera...	319	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	74.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04172 (show subtarget assignments)	1	purified	No	VC2268	9656830		riboflavin synthase, beta subunit [Vibri...	173	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3MK3	56.6%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP04173 (show subtarget assignments)	1	expressed	No	VC2490	15642486		2-isopropylmalate synthase [Vibrio chole...	516	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RMJ	39%	Vibrio cholerae	Amino acid biosynthesis	Pyruvate family

IDP04174 (show subtarget assignments)	1	diffraction	No	VC2508	15642504		ornithine carbamoyltransferase [Vibrio c...	334	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3UPD	82.6%	Vibrio cholerae	Amino acid biosynthesis	Glutamate family

IDP04175 (show subtarget assignments)	1	purified	No	VC2511	9657094		aspartate carbamoyltransferase, regulato...	155	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1D09	63.2%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04176 (show subtarget assignments)	1	in_pdb 3OKF	No	VC2628	15642623	aroB	3-dehydroquinate synthase [Vibrio choler...	366	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3OKF	100%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP04177 (show subtarget assignments)	1	crystallized	No	VC2629	9657219		shikimate kinase [Vibrio cholerae O1 bio...	174	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KAG	81%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP04178 (show subtarget assignments)	1	expressed	No	VC2718	15642712		bioH protein [Vibrio cholerae O1 biovar ...	268	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1M33	49.3%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04179 (show subtarget assignments)	1	cloned	No	VCA0068	15600839		methyl-accepting chemotaxis protein [Vib...	547	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3ZX6	18.3%	Vibrio cholerae	Cellular processes	Chemotaxis and motility

IDP04180 (show subtarget assignments)	1	expressed	No	VCA0141	15600911		C4-dicarboxylate transport sensor protei...	684	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3JZ3	9.9%	Vibrio cholerae	Regulatory functions	Other

IDP04181 (show subtarget assignments)	1	crystallized	No	VCA0197	9657589		GMP reductase [Vibrio cholerae O1 biovar...	347	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2A7R	63.4%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP04182 (show subtarget assignments)	1	cloned	No	VCA0238	15601006		sensor histidine kinase [Vibrio cholerae...	549	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	12%	Vibrio cholerae	Regulatory functions	Other

IDP04183 (show subtarget assignments)	1	expressed	No	VCA0257	15601025		sensor histidine kinase [Vibrio cholerae...	484	drug target; putative drug target function;	Phase 4: April 2009			Vibrio cholerae	Regulatory functions	Other

IDP04184 (show subtarget assignments)	1	expressed	No	VCA0522	15601282		sensor histidine kinase/response regulat...	686	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10.9%	Vibrio cholerae	Regulatory functions	Other

IDP04185 (show subtarget assignments)	1	expressed	No	VCA0683	15601440		sensor protein UhpB [Vibrio cholerae O1 ...	527	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3GIG	12%	Vibrio cholerae	Regulatory functions	Other

IDP04186 (show subtarget assignments)	1	cloned	No	VCA0709	9658128		sensor protein TorS [Vibrio cholerae O1 ...	1020	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3I9Y	17.1%	Vibrio cholerae	Regulatory functions	Other

IDP04187 (show subtarget assignments)	1	expressed	No	VCA0723	15601479		3-hydroxy-3-methylglutaryl CoA reductase...	436	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1DQ8	35.5%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04188 (show subtarget assignments)	1	expressed	No	VCA0939	15601692		sensory box/GGDEF family protein [Vibrio...	321	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3BRE	20.6%	Vibrio cholerae	Regulatory functions	Other

IDP04189 (show subtarget assignments)	1	expressed	No	CPF_0225	110799110		sensor histidine kinase [Clostridium per...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	13%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04190 (show subtarget assignments)	1	cloned	No	CPF_0544	110800679	spoVD	stage V sporulation protein D [Clostridi...	721	conserved gene; putative drug target function;	Phase 4: April 2009	1PYY	27.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04191 (show subtarget assignments)	1	expressed	No	CPF_0554	110800843		sensor histidine kinase [Clostridium per...	583	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP04192 (show subtarget assignments)	1	cloned	No	CPF_0671	110799768		phosphoribosylformylglycinamidine syntha...	1266	conserved gene; putative drug target function;	Phase 4: April 2009	3AC6	15.2%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04193 (show subtarget assignments)	1	cloned	No	CPF_2398	110799387	mreB	rod shape-determining protein MreB [Clos...	342	conserved gene; putative drug target function;	Phase 4: April 2009	1JCE	53.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04194 (show subtarget assignments)	1	cloned	No	CPF_2444	110799147	yyaC	putative sporulation protein YyaC [Clost...	176	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04195 (show subtarget assignments)	1	cloned	No	CPF_2448	110798809	spoIID	stage II sporulation protein D [Clostrid...	340	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04096
(show subtarget assignments)

1

purified

No

YPO2010

115347732

ychF

conserved hypothetical protein [Yersinia...

363

drug target; virulence factor; conserved gene;

Phase 4: April 2009

1JAL

79.6%

Yersinia pestis

Unknown function

General

IDP04097
(show subtarget assignments)

1

cloned

No

CPF_2217

110801384

yunB

sporulation protein YunB [Clostridium pe...

229

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04098
(show subtarget assignments)

1

cloned

No

YPCD1.50

5832470

YPCD1.50

hypothetical protein YPCD1.50 [Yersinia ...

32

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04099
(show subtarget assignments)

1

expressed

No

VC1027

9655490

molybdenum cofactor biosynthesis protein...

81

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1FM0

70.4%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP04100
(show subtarget assignments)

1

cloned

No

YPCD1.45

16082733

yscS

needle complex export protein [Yersinia ...

88

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04101
(show subtarget assignments)

1

purified

No

CPF_2392

110799105

minE

cell division topological specificity fa...

90

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Cell division

IDP04102
(show subtarget assignments)

1

cloned

No

YPO2227

218929324

pyrF

orotidine 5'-phosphate decarboxylase [Ye...

245

conserved gene; putative drug target function;

Phase 4: April 2009

1EIX

72.2%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04103
(show subtarget assignments)

1

cloned

No

YPO2280

218929372

putative phage-related secreted protein ...

414

putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04104
(show subtarget assignments)

1

expressed

No

YPO2309

115348012

rstB

two-component regulatory system, sensor ...

425

putative drug target function;

Phase 4: April 2009

2C2A

16.7%

Yersinia pestis

Regulatory functions

Other

IDP04105
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2391

115348093

ribC

riboflavin synthase alpha chain [Yersini...

218

conserved gene; putative drug target function;

Phase 4: April 2009

1I8D

74.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP04106
(show subtarget assignments)

1

cloned

No

BAS0124

49183158

30S ribosomal protein S8 [Bacillus anthr...

132

Proposed to be essential proteins

Phase 4: April 2009

1SEI

85.6%

Bacillus anthracis

IDP04107
(show subtarget assignments)

1

purified

No

BAS0120

49183154

50S ribosomal protein L14 [Bacillus anth...

122

Proposed to be essential proteins

Phase 4: April 2009

1C04

86.9%

Bacillus anthracis

IDP04108
(show subtarget assignments)

1

expressed

No

YPO0507

115346316

conserved hypothetical protein [Yersinia...

782

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2P5Z

13.7%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04109
(show subtarget assignments)

1

crystallized

No

GBAA3100

47528393

copper homeostasis protein CutC, putativ...

225

virulence factor; putative drug target function;

Phase 4: April 2009

2BDQ

30.7%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP04110
(show subtarget assignments)

1

expressed

No

YPO2440

218929529

yfeB

ATP-binding transport protein [Yersinia ...

296

virulence factor; conserved gene;

Phase 4: April 2009

3GFO

26.4%

Yersinia pestis

Unknown function

General

IDP04111
(show subtarget assignments)

1

cloned

No

YPO2524

115348222

menC

putative O-succinylbenzoate-CoA synthase...

323

conserved gene; putative drug target function;

Phase 4: April 2009

3GC2

66.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04112
(show subtarget assignments)

1

cloned

No

YPO2626

115348318

nagA

putative N-acetylglucosamine-6-phosphate...

381

drug target; putative drug target function;

Phase 4: April 2009

1YMY

75.1%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP04113
(show subtarget assignments)

1

selected

No

YPO2627

115348319

glmD

putative glucosamine-6-phosphate isomera...

266

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CD5

85.7%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP04114
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1611

115347358

conserved hypothetical protein [Yersinia...

117

drug target; conserved gene;

Phase 4: April 2009

3N1S

84.6%

Yersinia pestis

Unknown function

General

IDP04115
(show subtarget assignments)

1

expressed

No

STM2352_1_235

16765679

hisM

histidine/lysine/arginine/ornithine tran...

235

Salmonella essential protein

Phase 4: April 2009

3DHW

23.8%

Salmonella enterica

IDP04116
(show subtarget assignments)

1

expressed

No

Z5122

15804232

sepZ

hypothetical protein Z5122 [Escherichia ...

99

Effector protein

Phase 4: April 2009

Escherichia coli

IDP04117
(show subtarget assignments)

8

selected

No

CAC05825

12329094

spa13

spa13, component of the Mxi-Spa secretio...

112

Shigella effector protein

Community Requests

Shigella flexneri

IDP04118
(show subtarget assignments)

1

cloned

No

YPCD1.22c

5832443

YPCD1.22c

hypothetical protein YPCD1.22c [Yersinia...

129

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04119
(show subtarget assignments)

1

crystallized

No

BAS0131

49183165

adenylate kinase [Bacillus anthracis str...

216

Proposed to be essential proteins

Phase 4: April 2009

1ZIN

74.1%

Bacillus anthracis

IDP04120
(show subtarget assignments)

1

soluble

No

BAS1475

49184492

xanthine phosphoribosyltransferase [Baci...

197

Proposed to be essential proteins

Phase 4: April 2009

1Y0B

65%

Bacillus anthracis

IDP04121
(show subtarget assignments)

1

cloned

No

YPO2725

115348408

conserved hypothetical protein [Yersinia...

921

virulence factor; putative drug target function;

Phase 4: April 2009

2P5Z

12.6%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04122
(show subtarget assignments)

1

in_pdb
3OJC

Yes

YPO2758

115348441

putative aspartate/glutamate racemase [Y...

231

conserved gene; putative drug target function;

Phase 4: April 2009

3OJC

100%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP04123
(show subtarget assignments)

1

expressed

No

YPO2768

115348451

accD

acetyl-coenzyme A carboxylase carboxyl t...

304

conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

84.5%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04124
(show subtarget assignments)

1

crystallized

No

YPO2828

218929893

purI

phosphoribosylaminoimidazole synthetase ...

347

conserved gene; putative drug target function;

Phase 4: April 2009

1CLI

81.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04125
(show subtarget assignments)

1

cloned

No

YPO2847

115348521

yegM

putitive HlyD family secretion protein [...

444

conserved gene; putative drug target function;

Phase 4: April 2009

3FPP

21.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04126
(show subtarget assignments)

1

cloned

No

YPO2871

115348542

guaB

inosine-5'-monophosphate dehydrogenase [...

487

conserved gene; putative drug target function;

Phase 4: April 2009

1ZFJ

56.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04127
(show subtarget assignments)

1

crystallized

No

YPO2889

115348559

pepB

peptidase B [Yersinia pestis CO92]

432

drug target; putative drug target function;

Phase 4: April 2009

1BLL

32.9%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04128
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2899

115348569

suhB

putative inositol monophosphatase family...

267

putative drug target function;

Phase 4: April 2009

2QFL

83.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04129
(show subtarget assignments)

1

expressed

No

YPO0764

115346558

conserved hypothetical protein [Yersinia...

741

virulence factor; putative drug target function;

Phase 4: April 2009

2P5Z

16.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04130
(show subtarget assignments)

1

cloned

No

YPO2938

115348602

conserved hypothetical protein [Yersinia...

500

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04131
(show subtarget assignments)

1

cloned

No

YPO2947

115348609

conserved hypothetical protein [Yersinia...

626

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04132
(show subtarget assignments)

1

cloned

No

YPO2997

218930046

putative two-component system sensor kin...

449

putative drug target function;

Phase 4: April 2009

3JZ3

15.4%

Yersinia pestis

Regulatory functions

Other

IDP04133
(show subtarget assignments)

1

cloned

No

CPF_1195

110798868

hpkA

sensor histidine kinase [Clostridium per...

287

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

25.8%

Clostridium perfringens

Regulatory functions

Other

IDP04134
(show subtarget assignments)

1

expressed

No

FTT0666c

56707787

methylpurine-DNA glycosylase family prot...

193

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BNK

39.7%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP04135
(show subtarget assignments)

1

cloned

No

BAS4470

49187465

50S ribosomal protein L35 [Bacillus anth...

66

Proposed to be essential proteins

Phase 4: April 2009

1VS6

48.5%

Bacillus anthracis

IDP04136
(show subtarget assignments)

1

diffraction

No

GBAA4258

47529551

5-methylthio-3-oxo-1-penten-1,2-diol dio...

170

putative drug target function;

Phase 4: April 2009

1ZRR

31.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP04137
(show subtarget assignments)

1

soluble

No

BAS0134

49183168

50S ribosomal protein L36 [Bacillus anth...

37

Proposed to be essential proteins

Phase 4: April 2009

1DFE

81.1%

Bacillus anthracis

IDP04138
(show subtarget assignments)

1

expressed

No

YPO0811

218927991

general secretion pathway protein I [Yer...

114

putative drug target function;

Phase 4: April 2009

3CI0

19.3%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04139
(show subtarget assignments)

1

soluble

No

YPO2999

218930048

putative HlyD family secretion protein [...

401

putative drug target function;

Phase 4: April 2009

4DK0

35.9%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04140
(show subtarget assignments)

1

cloned

No

YPO3116

115348760

ascD

cdp-6-deoxy-delta-3,4-glucoseen reductas...

329

virulence factor; putative drug target function;

Phase 4: April 2009

1KRH

26.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04141
(show subtarget assignments)

1

in_pdb
3V4H

Yes

YPO2937

115348601

conserved hypothetical protein [Yersinia...

161

virulence factor; conserved gene;

Phase 4: April 2009

3V4H

100%

Yersinia pestis

Hypothetical proteins

Conserved

IDP04142
(show subtarget assignments)

1

purified

No

YPO3191

218930221

tgt

queuine tRNA-ribosyltransferase [Yersini...

374

drug target; putative drug target function;

Phase 4: April 2009

1OZM

55.1%

Yersinia pestis

Protein synthesis

tRNA and rRNA base modification

IDP04143
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3275

115348911

clpB

Clp ATPase [Yersinia pestis CO92]

857

drug target; putative drug target function;

Phase 4: April 2009

1QVR

57.1%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04144
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3337

218930358

map

methionine aminopeptidase [Yersinia pest...

261

drug target; virulence factor; putative drug target function;

Community Interest

1C21

55.2%

Yersinia pestis

Protein fate

Protein modification and repair

IDP04145
(show subtarget assignments)

1

expressed

No

YPO3422

115349050

ampE

putative membrane-bound sensory transduc...

284

conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP04146
(show subtarget assignments)

1

expressed

No

YPO2147

218929248

dadA

D-amino acid dehydrogenase small subunit...

434

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1PJ5

19.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04147
(show subtarget assignments)

1

expressed

No

YPO3427

115349055

hofC

putative type II secretion system protei...

399

conserved gene; putative drug target function;

Phase 4: April 2009

2VMA

9.8%

Yersinia pestis

Energy metabolism

Electron transport

IDP04148
(show subtarget assignments)

1

expressed

No

YPO3508

115349133

basS

two-component system sensor protein [Yer...

355

conserved gene; putative drug target function;

Phase 4: April 2009

3JZ3

23.1%

Yersinia pestis

Regulatory functions

Other

IDP04149
(show subtarget assignments)

1

expressed

No

YPO3706

115349323

conserved hypothetical protein [Yersinia...

493

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04150
(show subtarget assignments)

1

purified

No

YPO3707

115349324

conserved hypothetical protein [Yersinia...

165

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04151
(show subtarget assignments)

1

cloned

No

YPO3864

218930867

nfrC

UDP-N-acetylglucosamine 2-epimerase [Yer...

376

drug target; putative drug target function;

Phase 4: April 2009

1F6D

78.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04152
(show subtarget assignments)

1

cloned

No

YPO3919

218930919

HlyD family secretion protein [Yersinia ...

442

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04153
(show subtarget assignments)

1

cloned

No

YPO3975

218930970

opdA

oligopeptidase A [Yersinia pestis CO92]

680

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1S4B

30.7%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04154
(show subtarget assignments)

1

cloned

No

YPO4017

218931008

hutU

urocanate hydratase [Yersinia pestis CO9...

563

conserved gene; putative drug target function;

Phase 4: April 2009

1UWL

86.3%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04155
(show subtarget assignments)

1

cloned

No

VC0547

9654975

aspartokinase, alpha and beta subunits [...

395

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3L76

39.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP04156
(show subtarget assignments)

1

expressed

No

VC0681

9655120

riboflavin kinase/FMN adenylyltransferas...

322

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1MRZ

32.3%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP04157
(show subtarget assignments)

1

soluble

No

VC1085

15641098

sensor histidine kinase [Vibrio cholerae...

434

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.1%

Vibrio cholerae

Regulatory functions

Other

IDP04158
(show subtarget assignments)

1

expressed

No

VC1088

15641101

sensor histidine kinase [Vibrio cholerae...

534

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3D36

13.5%

Vibrio cholerae

Regulatory functions

Other

IDP04159
(show subtarget assignments)

1

cloned

No

VC1134

15641147

histidinol-phosphate aminotransferase [V...

346

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1FG3

59.8%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP04160
(show subtarget assignments)

1

in_pdb
3NAV

No

VC1169

9655645

tryptophan synthase, alpha subunit [Vibr...

268

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3NAV

100%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP04161
(show subtarget assignments)

1

cloned

No

VC1172

9655648

anthranilate phosphoribosyltransferase [...

353

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KGZ

59.5%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP04162
(show subtarget assignments)

1

expressed

No

VC1190

15641203

hemH

phosphoribosylaminoimidazole-succinocarb...

405

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3R9R

25.4%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04163
(show subtarget assignments)

1

expressed

No

VC1349

15641361

sensory box sensor histidine kinase/resp...

1331

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

6.5%

Vibrio cholerae

Regulatory functions

Other

IDP04164
(show subtarget assignments)

1

cloned

No

VC1445

15641456

sensor histidine kinase/response regulat...

572

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

14.5%

Vibrio cholerae

Regulatory functions

Other

IDP04165
(show subtarget assignments)

1

expressed

No

VC1521

15641529

sensor histidine kinase [Vibrio cholerae...

677

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

11.7%

Vibrio cholerae

Regulatory functions

Other

IDP04166
(show subtarget assignments)

1

cloned

No

VC1653

15641658

sensory box sensor histidine kinase/resp...

1146

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

6.6%

Vibrio cholerae

Regulatory functions

Other

IDP04167
(show subtarget assignments)

1

cloned

No

VC1977

9656518

aspartate aminotransferase, putative [Vi...

404

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XI9

40.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP04168
(show subtarget assignments)

1

purified

No

VC2142

15642141

flagellin [Vibrio cholerae O1 biovar elt...

376

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3K8V

37.5%

Vibrio cholerae

Cellular processes

Chemotaxis and motility

IDP04169
(show subtarget assignments)

1

in_crystallization_trials

No

VC2180

15642179

hemA

glutamyl-tRNA reductase [Vibrio cholerae...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GPJ

35.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04170
(show subtarget assignments)

1

cloned

No

VC2183

15642182

ribose-phosphate pyrophosphokinase [Vibr...

314

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3DAH

63.7%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04171
(show subtarget assignments)

1

cloned

No

VC2244

15642242

acetyl-CoA carboxylase carboxyltransfera...

319

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

74.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04172
(show subtarget assignments)

1

purified

No

VC2268

9656830

riboflavin synthase, beta subunit [Vibri...

173

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3MK3

56.6%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP04173
(show subtarget assignments)

1

expressed

No

VC2490

15642486

2-isopropylmalate synthase [Vibrio chole...

516

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RMJ

39%

Vibrio cholerae

Amino acid biosynthesis

Pyruvate family

IDP04174
(show subtarget assignments)

1

diffraction

No

VC2508

15642504

ornithine carbamoyltransferase [Vibrio c...

334

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3UPD

82.6%

Vibrio cholerae

Amino acid biosynthesis

Glutamate family

IDP04175
(show subtarget assignments)

1

purified

No

VC2511

9657094

aspartate carbamoyltransferase, regulato...

155

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1D09

63.2%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04176
(show subtarget assignments)

1

in_pdb
3OKF

No

VC2628

15642623

aroB

3-dehydroquinate synthase [Vibrio choler...

366

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3OKF

100%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP04177
(show subtarget assignments)

1

crystallized

No

VC2629

9657219

shikimate kinase [Vibrio cholerae O1 bio...

174

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KAG

81%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP04178
(show subtarget assignments)

1

expressed

No

VC2718

15642712

bioH protein [Vibrio cholerae O1 biovar ...

268

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1M33

49.3%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04179
(show subtarget assignments)

1

cloned

No

VCA0068

15600839

methyl-accepting chemotaxis protein [Vib...

547

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3ZX6

18.3%

Vibrio cholerae

Cellular processes

Chemotaxis and motility

IDP04180
(show subtarget assignments)

1

expressed

No

VCA0141

15600911

C4-dicarboxylate transport sensor protei...

684

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3JZ3

9.9%

Vibrio cholerae

Regulatory functions

Other

IDP04181
(show subtarget assignments)

1

crystallized

No

VCA0197

9657589

GMP reductase [Vibrio cholerae O1 biovar...

347

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2A7R

63.4%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP04182
(show subtarget assignments)

1

cloned

No

VCA0238

15601006

sensor histidine kinase [Vibrio cholerae...

549

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

12%

Vibrio cholerae

Regulatory functions

Other

IDP04183
(show subtarget assignments)

1

expressed

No

VCA0257

15601025

sensor histidine kinase [Vibrio cholerae...

484

drug target; putative drug target function;

Phase 4: April 2009

Vibrio cholerae

Regulatory functions

Other

IDP04184
(show subtarget assignments)

1

expressed

No

VCA0522

15601282

sensor histidine kinase/response regulat...

686

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10.9%

Vibrio cholerae

Regulatory functions

Other

IDP04185
(show subtarget assignments)

1

expressed

No

VCA0683

15601440

sensor protein UhpB [Vibrio cholerae O1 ...

527

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3GIG

12%

Vibrio cholerae

Regulatory functions

Other

IDP04186
(show subtarget assignments)

1

cloned

No

VCA0709

9658128

sensor protein TorS [Vibrio cholerae O1 ...

1020

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3I9Y

17.1%

Vibrio cholerae

Regulatory functions

Other

IDP04187
(show subtarget assignments)

1

expressed

No

VCA0723

15601479

3-hydroxy-3-methylglutaryl CoA reductase...

436

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1DQ8

35.5%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04188
(show subtarget assignments)

1

expressed

No

VCA0939

15601692

sensory box/GGDEF family protein [Vibrio...

321

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3BRE

20.6%

Vibrio cholerae

Regulatory functions

Other

IDP04189
(show subtarget assignments)

1

expressed

No

CPF_0225

110799110

sensor histidine kinase [Clostridium per...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

13%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04190
(show subtarget assignments)

1

cloned

No

CPF_0544

110800679

spoVD

stage V sporulation protein D [Clostridi...

721

conserved gene; putative drug target function;

Phase 4: April 2009

1PYY

27.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04191
(show subtarget assignments)

1

expressed

No

CPF_0554

110800843

sensor histidine kinase [Clostridium per...

583

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP04192
(show subtarget assignments)

1

cloned

No

CPF_0671

110799768

phosphoribosylformylglycinamidine syntha...

1266

conserved gene; putative drug target function;

Phase 4: April 2009

3AC6

15.2%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04193
(show subtarget assignments)

1

cloned

No

CPF_2398

110799387

mreB

rod shape-determining protein MreB [Clos...

342

conserved gene; putative drug target function;

Phase 4: April 2009

1JCE

53.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04194
(show subtarget assignments)

1

cloned

No

CPF_2444

110799147

yyaC

putative sporulation protein YyaC [Clost...

176

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04195
(show subtarget assignments)

1

cloned

No

CPF_2448

110798809

spoIID

stage II sporulation protein D [Clostrid...

340

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

Targets