Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01850 (show subtarget assignments)	1	cloned	No	FTT0916c	56708017	ribF	riboflavin biosynthesis protein RibF [Fr...	306	Drug Target	Phase 3: June 2008	1MRZ	30.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP92006 (show subtarget assignments)	8	selected	No	FTN_0818	118497410		lipase/esterase [Francisella novicida U1...	306	virulence/pathogenesis / We have shown that this protein is involved in Francisella virulence in vivo and...	Community Requests	3AIK	33.3%	Francisella novicida

IDP92007 (show subtarget assignments)	8	selected	No	FTT_0941c	56708038		unnamed protein product [Francisella tul...	306	virulence/pathogenesis / We have shown that this protein is involved in Francisella virulence in vivo and...	Community Requests	3AIK	33%	Francisella tularensis

IDP90738 (show subtarget assignments)	8	soluble	No	Cj0116	15791504	fabD	malonyl CoA-acyl carrier protein transac...	306	Predicted Essential	Community Requests	2H1Y	49.3%	Campylobacter jejuni

IDP91586 (show subtarget assignments)	8	expressed	No	CBU_1107	29541681		hypothetical protein	306	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91796 (show subtarget assignments)	8	in_crystallization_trials	No	AAB49832	1854639		gentamicin resistance protein [Enterococ...	306	other biological interest / Kinase	Community Requests	3TDV	100%	Enterococcus gallinarum

IDP90828 (show subtarget assignments)	8	in_pdb 3TPF	No	Cj0994c	15792321	argF	ornithine carbamoyltransferase [Campylob...	306	Predicted Essential	Community Requests	3TPF	100%	Campylobacter jejuni

IDP04508 (show subtarget assignments)	1	cloned	No	CPF_0372	110799482		polysaccharide deacetylase family protei...	306	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NY1	17.6%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP05227 (show subtarget assignments)	1	soluble	No	lmo0541	16802584	-	hypothetical protein lmo0541 [Listeria m...	306	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3EIW	28.1%	Listeria monocytogenes	Transport and binding proteins: Cations and iron carrying compounds

IDP00126 (show subtarget assignments)	1	soluble	No	NT01ST1449	16764525	mviM	putative virulence protein	307	Virulence	Phase 1: October 2007	1TLT	81.4%	Salmonella enterica	Cellular processes	Pathogenesis

IDP02257 (show subtarget assignments)	1	expressed	No	CBU_2074	29542624	hemC	porphobilinogen deaminase [Coxiella burn...	307	Conserved; Drug target functions	Phase 3: June 2008	1AH5	46.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04416 (show subtarget assignments)	1	in_crystallization_trials	No	BAS4049	49187047		ribonuclease Z [Bacillus anthracis str. ...	307	Proposed to be essential proteins	Phase 4: April 2009	1Y44	61.2%	Bacillus anthracis

IDP91798 (show subtarget assignments)	8	purified	No	AAX82592	62422020	aph(6)-Ia	aminoglycoside-6-phosphotransferase Ia [...	307	other biological interest / Kinase	Community Requests			Streptomyces griseus

IDP00723 (show subtarget assignments)	1	cloned	No	SACOL1668	57284681		peptidase, U32 family	307	Drug Target Function	Phase 2: March 2008			Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90701 (show subtarget assignments)	8	soluble	No	Cj0545	15791906	hemC	porphobilinogen deaminase [Campylobacter...	307	Predicted Essential	Community Requests	1AH5	47.9%	Campylobacter jejuni

IDP02538 (show subtarget assignments)	1	soluble	No	FTT1746	56708744		peptidase [Francisella tularensis subsp....	307	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3RST	23.1%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00658 (show subtarget assignments)	0	work_stopped	No	SACOL0801	57285762	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	307	Drug Target Function	Phase 2: March 2008	1HSK	99.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02514 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0116	29540736	mraW	S-adenosyl-methyltransferase MraW [Coxie...	307	Conserved; Drug target functions	Phase 3: June 2008	1WG8	46.9%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP02497 (show subtarget assignments)	1	cloned	No	FTT1287	56708346	cbs	cystathionine beta-synthase (cystein syn...	307	Conserved; Drug target functions	Phase 3: June 2008	4AEC	33.2%	Francisella tularensis	Amino acid biosynthesis	Serine family

IDP01160 (show subtarget assignments)	1	expressed	No	BA_4774	30259261		bacitracin ABC transporter, ATP-binding ...	307	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	25.7%	Bacillus anthracis	Transport and binding proteins	Other

IDP02300 (show subtarget assignments)	1	soluble	No	GBAA1860	47527151		alpha/beta fold family hydrolase [Bacill...	307	Drug target motif; Involved in sporulation;	Phase 3: June 2008	3HJU	26.7%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01135 (show subtarget assignments)	1	expressed	No	BA_3911	30258425		renal dipeptidase family protein	307	Drug Target Function	Phase 2: March 2008	3LU2	45.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02227 (show subtarget assignments)	1	cloned	No	FTT1063	56708148	hemF	coproporphyrinogen III oxidase [Francise...	308	Drug Target	Phase 3: June 2008	1VJU	51.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP91938 (show subtarget assignments)	8	selected	No	SpneCM_010100009513	298255813		cell division ABC transporter, permease ...	308	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP02000 (show subtarget assignments)	1	cloned	No	YPO0008	16120361	rbsK	ribokinase [Yersinia pestis CO92]	308	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1GQT	70.5%	Yersinia pestis	Energy metabolism	Pentose phosphate pathway

IDP91196 (show subtarget assignments)	8	soluble	No	BAS4097	49187095	-	Stage III sporulation protein AA	308	essential/virulence/pathogenesis / Essential proteins	Community Requests			Bacillus anthracis

IDP05685 (show subtarget assignments)	1	soluble	No	lmo1426	16803466	opuCC	hypothetical protein lmo1426 [Listeria m...	308	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PPN	57.1%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP00796 (show subtarget assignments)	0	work_stopped	No	SACOL1244	57285984	fabD	malonyl CoA-acyl carrier protein transac...	308	Drug Target Function	Phase 2: March 2008	3IM9	98.7%	Staphylococcus aureus	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01609 (show subtarget assignments)	1	crystallized	No	FTT1512c	56708550	dnaJ1	heat shock protein, hsp40 [Francisella t...	308	Conserved; Drug target functions	Phase 3: June 2008	3LZ8	34.2%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP00769 (show subtarget assignments)	0	work_stopped	No	SACOL0472	57285499		superantigen-like protein	308	Virulence Associated Factor	Phase 2: March 2008	3URY	60.7%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00746 (show subtarget assignments)	1	purified	No	SACOL1717	57284728	hemC	porphobilinogen deaminase	308	Drug Target Function	Phase 2: March 2008	1PDA	45.1%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02833 (show subtarget assignments)	1	cloned	No	GBAA4561	47529857	aroE	shikimate 5-dehydrogenase [Bacillus anth...	308	Conserved; Drug target functions	Phase 3: June 2008	2EGG	49.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP05406 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0669	30254269	rbsB	ribose ABC transporter, ribose-binding p...	308	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IOY	51.9%	Bacillus anthracis	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP02751 (show subtarget assignments)	1	expressed	No	FTT0634	56707759	hflC	SPFH domain-containing protein/band 7 fa...	308	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3BK6	13.6%	Francisella tularensis	Protein fateRegulatory functions	Degradation of proteins, peptides, and glycopeptidesProtein interactions

IDP02710 (show subtarget assignments)	1	in_pdb 3LU2	No	lmo2462	16804500		hypothetical protein lmo2462 [Listeria m...	308	Presence of Protease Motifs; DNA binding Motifs	Phase 3: June 2008	3LU2	100%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02598 (show subtarget assignments)	1	cloned	No	Cj1429c	15792747		hypothetical protein Cj1429c [Campylobac...	308	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04436 (show subtarget assignments)	1	expressed	No	YPCD1.97c	5832512	YPCD1.97c	putative transposase [Yersinia pestis CO...	308	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP01126 (show subtarget assignments)	1	cloned	No	BA_5392	47115756		HPr kinase/phosphorylase (HPrK/P) (HPr(S...	309	Conserved Gene / Pathway	Phase 2: March 2008	1KO7	59.2%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00559 (show subtarget assignments)	1	purified	No	YPO3032	16123209	hemF	coproporphyrinogen III oxidase	309	Conserved Gene / Pathway	Phase 2: March 2008	3E8J	59.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90501 (show subtarget assignments)	8	purified	No	Q9KP66	22257009		RecName: Full=Aspartate carbamoyltransfe...	309	Predicted Essential	Community Requests	2BE7	77.7%	Vibrio cholerae

IDP92029 (show subtarget assignments)	8	selected	No	TGME49_018920	237842737		proteasome subunit beta type 5, putative...	309	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3NZJ	42.7%	Toxoplasma gondii

IDP00108 (show subtarget assignments)	1	purified	No	NT01SF4751	30043076	fdhE	FdhE protein	309	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FIY	39.5%	Shigella flexneri	Central intermediary metabolism	Other

IDP00956 (show subtarget assignments)	1	in_pdb 3H0P	No	STM1194	16764549	fabD	acyl carrier protein S-malonyltransferas...	309	potential drug target / Essential Gene	Phase 2: March 2008	3H0P	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00025 (show subtarget assignments)	1	purified	No	BA_0285	30253779		bacitracin ABC transporter, ATP-binding ...	309	Virulence	Phase 1: October 2007	1OXS	30.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP05696 (show subtarget assignments)	1	expressed	No	lmo2170	16804209	-	hypothetical protein lmo2170 [Listeria m...	309	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3BO9	48.9%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP01720 (show subtarget assignments)	1	cloned	No	Cj1128c	15792453	wlaD	general glycosylation pathway protein [C...	309	Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...	Phase 3: June 2008	3BCV	16.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01663 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4696	47529995	hemC	porphobilinogen deaminase [Bacillus anth...	309	Conserved; Drug target functions	Phase 3: June 2008	1AH5	46.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP91827 (show subtarget assignments)	8	soluble	No	b1723	1788017	pfkB	6-phosphofructokinase II [Escherichia co...	309	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	3CQD	100%	Escherichia coli

IDP00426 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1598	16121866	fabD	acyl carrier protein S-malonyltransferas...	309	Conserved Gene / Pathway	Phase 2: March 2008	3H0P	79.3%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01614 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2581	16122794		putative sugar-binding periplasmic prote...	309	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2IOY	29.5%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04720 (show subtarget assignments)	1	expressed	No	YPO1174	115346948		hypothetical protein [Yersinia pestis CO...	309	virulence factor; putative drug target function;	Phase 4: April 2009	3ULT	12.6%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP00042 (show subtarget assignments)	1	soluble	No	BA_2507	30257134	bla1	beta-lactamase	309	Virulence	Phase 1: October 2007	3QHY	87.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP05756 (show subtarget assignments)	1	cloned	No	lmo0814	16802856	-	hypothetical protein lmo0814 [Listeria m...	309	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3BO9	50.2%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP04017 (show subtarget assignments)	1	cloned	No	CPF_1035	110799411		putative lipoprotein [Clostridium perfri...	309	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP00733 (show subtarget assignments)	1	selected	No	SACOL2419	57285149	hlgA	gamma-hemolysin, component A	309	Conserved Gene / Pathway	Phase 2: March 2008	2QK7	90.9%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP91385 (show subtarget assignments)	8	soluble	No	VV1_1465	27364849	pyrB	aspartate carbamoyltransferase catalytic...	309	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2BE7	76.4%	Vibrio vulnificus

IDP91248 (show subtarget assignments)	8	soluble	No	HP0090	2313169		malonyl coenzyme A-acyl carrier protein ...	309	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2H1Y	98.1%	Helicobacter pylori	Fatty acid and phospholipid metabolism: Biosynthesis

IDP90686 (show subtarget assignments)	8	crystallized	No	Cj0918c	15792247	prsA	ribose-phosphate pyrophosphokinase [Camp...	309	Predicted Essential	Community Requests	3DAH	57.1%	Campylobacter jejuni

IDP05514 (show subtarget assignments)	1	purified	No	CD1315	126698913	ribC	riboflavin biosynthesis protein [Clostri...	309	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1MRZ	32.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP04422 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4023	47529316	pyrD	dihydroorotate dehydrogenase 1B [Bacillu...	309	putative drug target function;	Phase 4: April 2009	1EP1	68%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04304 (show subtarget assignments)	1	cloned	No	CPF_2640	110798722		sensor histidine kinase [Clostridium per...	310	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	23.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP90552 (show subtarget assignments)	8	soluble	No	YPO0058	16120411	rfaD	ADP-L-glycero-D-mannoheptose-6-epimerase...	310	Predicted Essential	Community Requests	1EQ2	82.3%	Yersinia pestis

IDP91419 (show subtarget assignments)	8	in_pdb 4E0B	No	VV1_0673	27364130		malate dehydrogenase [Vibrio vulnificus ...	310	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	4E0B	100%	Vibrio vulnificus

IDP05286 (show subtarget assignments)	1	cloned	No	CD0232	126697803	flgL	flagellar hook-associated protein [Clost...	310	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3PWX	17.1%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP92089 (show subtarget assignments)	8	selected	No	TGME49_118320	237840947		ATP-dependent Clp protease proteolytic s...	310	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3QWD	21.9%	Toxoplasma gondii

IDP92000 (show subtarget assignments)	8	selected	No	SpneCM_010100010043	298255919		membrane protein [Streptococcus pneumoni...	310	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3UB1	17.7%	Streptococcus pneumoniae

IDP05123 (show subtarget assignments)	1	soluble	No	BA_3845	30258363		conserved domain protein [Bacillus anthr...	310	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Domain

IDP04296 (show subtarget assignments)	1	selected	No	YPO2556	218929642	hexA	LysR-family transcriptional regulatory p...	310	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3ONM	70.6%	Yersinia pestis	Regulatory functions	Other

IDP91249 (show subtarget assignments)	8	soluble	No	NT01LM0800	16410126	lmo0737	lmo0737 [Listeria monocytogenes]	310	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Listeria monocytogenes	Hypothetical proteins: Conserved

IDP02673 (show subtarget assignments)	1	expressed	No	STM4466	16767711		carbamate kinase [Salmonella typhimurium...	310	Conserved; Drug target functions	Phase 3: June 2008	1E19	45.5%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP91739 (show subtarget assignments)	8	selected	No	Q6V4K9_STRPY	0			310	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2XNX	17.1%	Streptococcus pyogenes

IDP02508 (show subtarget assignments)	1	cloned	No	lmo1847	16803887		hypothetical protein lmo1847 [Listeria m...	310	Known virulence-Invasion; PMID:12496198	Phase 3: June 2008	1PSZ	52.3%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP01219 (show subtarget assignments)	1	purified	No	BA_3767	30258283		prophage LambdaBa01, N-acetylmuramoyl-L-...	310	Drug Target Function	Phase 2: March 2008	2L47	40.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90090 (show subtarget assignments)	8	expressed	No	ZZZ_0006				310	This protein is a component of a type VI secretion system of enteroaggregative E...	Community Requests			Escherichia coli

IDP01192 (show subtarget assignments)	1	purified	No	BA_1184	34098435		3-oxoacyl-[acyl-carrier-protein] synthas...	310	Drug Target Function	Phase 2: March 2008	1ZOW	61%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04488 (show subtarget assignments)	1	expressed	No	YPO3685	115349305	yhcQ	putative HlyD family secretion protein [...	311	conserved gene; putative drug target function;	Phase 4: April 2009	2F1M	17%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP05585 (show subtarget assignments)	1	soluble	No	Z0801	12513558	ybeK	putative tRNA synthetase [Escherichia co...	311	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1YOE	99.4%	Escherichia coli	Protein synthesis: tRNA aminoacylation

IDP90587 (show subtarget assignments)	8	in_pdb 3LXM	Yes	YPO3588	16123730	pyrB	aspartate carbamoyltransferase catalytic...	311	Predicted Essential	Community Requests	3LXM	100%	Yersinia pestis

IDP91867 (show subtarget assignments)	8	selected	No	SUB0057	222152254		DNA-binding protein [Streptococcus uberi...	311	Proteins of the ComR family of Rgg regulators are important for horiz...	Community Requests			Streptococcus uberis

IDP04682 (show subtarget assignments)	1	cloned	No	GBAA3189	47528481		adhesion lipoprotein [Bacillus anthracis...	311	virulence factor; putative drug target function;	Phase 4: April 2009	3HH8	49.8%	Bacillus anthracis	Cell envelope	Other

IDP01382 (show subtarget assignments)	1	cloned	No	VC0533	15640555		lipoprotein NlpD	311	Drug Target Function	Phase 2: March 2008	1QWY	24.1%	Vibrio cholerae	Cell envelope	Other

IDP91091 (show subtarget assignments)	8	cloned	No	APL_0387	126096663	kpsF	arabinose-5-phosphate isomerase [Actinob...	311	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	27%	Actinobacillus pleuropneumoniae

IDP04371 (show subtarget assignments)	1	expressed	No	GBAA4776	47778322		sensor histidine kinase [Bacillus anthra...	311	putative drug target function;	Phase 4: April 2009	2C2A	19.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01149 (show subtarget assignments)	1	purified	No	BA_1195	30254908		oligopeptide ABC transporter, ATP-bindin...	311	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	30.2%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP90832 (show subtarget assignments)	8	in_pdb 3R9U	Yes	Cj0146c	15791534	trxB	thioredoxin-disulfide reductase [Campylo...	312	Predicted Essential	Community Requests	3R9U	100%	Campylobacter jejuni

IDP02039 (show subtarget assignments)	1	expressed	No	YPO1198	16121491		putative ABC transport ATP-binding subun...	312	Conserved; CD; Drug target functions	Phase 3: June 2008	1V43	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02013 (show subtarget assignments)	1	cloned	No	STM2395	16765721	pgtE	outer membrane protease [Salmonella typh...	312	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	2X55	69.9%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP02007 (show subtarget assignments)	1	in_crystallization_trials	No	STM2330	16765657	lrhA	NADH dehydrogenase transcriptional repre...	312	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3ONM	38.8%	Salmonella enterica	Energy metabolism	Aerobic

IDP00951 (show subtarget assignments)	1	in_pdb 3PP8 3KBO	No	STM1135	16764491	ycdW	putative oxidoreductase	312	Conserved Gene / Pathway	Phase 2: March 2008	3KBO	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP05606 (show subtarget assignments)	1	crystal_structure	No	BA_4837	30259338	mdh	malate dehydrogenase [Bacillus anthracis...	312	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TL2	100%	Bacillus anthracis	Energy metabolism: TCA cycle

IDP00902 (show subtarget assignments)	1	expressed	No	STM0045	16763435	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Conserved Gene / Pathway	Phase 2: March 2008	1MRZ	33%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP05398 (show subtarget assignments)	1	soluble	No	BA_3750	30258269		putative phosphonate ABC transporter, ph...	312	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3N5L	21.8%	Bacillus anthracis	Transport and binding proteins: Other

IDP90654 (show subtarget assignments)	8	expressed	No	YPO0474	16120803	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Predicted Essential	Community Requests	1MRZ	32.1%	Yersinia pestis

IDP01440 (show subtarget assignments)	1	in_pdb 3HJV	No	VC2022	15642024		acyl carrier protein S-malonyltransferas...	312	Drug Target Function	Phase 2: March 2008	3HJV	100%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP91276 (show subtarget assignments)	8	soluble	No	NT05BA4392	49181134		ribosomal protein L11 methyltransferase ...	312	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3GRZ	26.9%	Bacillus anthracis	Protein synthesis: Ribosomal proteins: synthesis and modification

IDP01415 (show subtarget assignments)	1	in_crystallization_trials	No	VC1363	15641375		siroheme synthase component enzyme	312	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	29.6%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00353 (show subtarget assignments)	1	in_crystallization_trials	No	lmo2202	16804241		3-oxoacyl-(acyl carrier protein) synthas...	312	Drug Target Function	Phase 2: March 2008	1ZOW	58.1%	Listeria monocytogenes	Fatty acid and phospholipid metabolism	Biosynthesis

IDP91610 (show subtarget assignments)	8	in_crystallization_trials	No	BAB37977	13364029	ECs4554	EspB protein [Escherichia coli O157:H7 s...	312	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP91814 (show subtarget assignments)	8	soluble	No	b3236	1789632	mdh	malate dehydrogenase, NAD(P)-binding [Es...	312	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	2PWZ	100%	Escherichia coli

IDP05721 (show subtarget assignments)	1	expressed	No	BA_2686	30257298		hypothetical protein BA_2686 [Bacillus a...	312	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP01850
(show subtarget assignments)

1

cloned

No

FTT0916c

56708017

ribF

riboflavin biosynthesis protein RibF [Fr...

306

Drug Target

Phase 3: June 2008

1MRZ

30.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP92006
(show subtarget assignments)

8

selected

No

FTN_0818

118497410

lipase/esterase [Francisella novicida U1...

306

virulence/pathogenesis / We have shown that this protein is involved in Francisella virulence in vivo and...

Community Requests

3AIK

33.3%

Francisella novicida

IDP92007
(show subtarget assignments)

8

selected

No

FTT_0941c

56708038

unnamed protein product [Francisella tul...

306

virulence/pathogenesis / We have shown that this protein is involved in Francisella virulence in vivo and...

Community Requests

3AIK

33%

Francisella tularensis

IDP90738
(show subtarget assignments)

8

soluble

No

Cj0116

15791504

fabD

malonyl CoA-acyl carrier protein transac...

306

Predicted Essential

Community Requests

2H1Y

49.3%

Campylobacter jejuni

IDP91586
(show subtarget assignments)

8

expressed

No

CBU_1107

29541681

hypothetical protein

306

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91796
(show subtarget assignments)

8

in_crystallization_trials

No

AAB49832

1854639

gentamicin resistance protein [Enterococ...

306

other biological interest / Kinase

Community Requests

3TDV

100%

Enterococcus gallinarum

IDP90828
(show subtarget assignments)

8

in_pdb
3TPF

No

Cj0994c

15792321

argF

ornithine carbamoyltransferase [Campylob...

306

Predicted Essential

Community Requests

3TPF

100%

Campylobacter jejuni

IDP04508
(show subtarget assignments)

1

cloned

No

CPF_0372

110799482

polysaccharide deacetylase family protei...

306

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NY1

17.6%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP05227
(show subtarget assignments)

1

soluble

No

lmo0541

16802584

-

hypothetical protein lmo0541 [Listeria m...

306

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3EIW

28.1%

Listeria monocytogenes

Transport and binding proteins: Cations and iron carrying compounds

IDP00126
(show subtarget assignments)

1

soluble

No

NT01ST1449

16764525

mviM

putative virulence protein

307

Virulence

Phase 1: October 2007

1TLT

81.4%

Salmonella enterica

Cellular processes

Pathogenesis

IDP02257
(show subtarget assignments)

1

expressed

No

CBU_2074

29542624

hemC

porphobilinogen deaminase [Coxiella burn...

307

Conserved; Drug target functions

Phase 3: June 2008

1AH5

46.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04416
(show subtarget assignments)

1

in_crystallization_trials

No

BAS4049

49187047

ribonuclease Z [Bacillus anthracis str. ...

307

Proposed to be essential proteins

Phase 4: April 2009

1Y44

61.2%

Bacillus anthracis

IDP91798
(show subtarget assignments)

8

purified

No

AAX82592

62422020

aph(6)-Ia

aminoglycoside-6-phosphotransferase Ia [...

307

other biological interest / Kinase

Community Requests

Streptomyces griseus

IDP00723
(show subtarget assignments)

1

cloned

No

SACOL1668

57284681

peptidase, U32 family

307

Drug Target Function

Phase 2: March 2008

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90701
(show subtarget assignments)

8

soluble

No

Cj0545

15791906

hemC

porphobilinogen deaminase [Campylobacter...

307

Predicted Essential

Community Requests

1AH5

47.9%

Campylobacter jejuni

IDP02538
(show subtarget assignments)

1

soluble

No

FTT1746

56708744

peptidase [Francisella tularensis subsp....

307

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3RST

23.1%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00658
(show subtarget assignments)

0

work_stopped

No

SACOL0801

57285762

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

307

Drug Target Function

Phase 2: March 2008

1HSK

99.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02514
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0116

29540736

mraW

S-adenosyl-methyltransferase MraW [Coxie...

307

Conserved; Drug target functions

Phase 3: June 2008

1WG8

46.9%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP02497
(show subtarget assignments)

1

cloned

No

FTT1287

56708346

cbs

cystathionine beta-synthase (cystein syn...

307

Conserved; Drug target functions

Phase 3: June 2008

4AEC

33.2%

Francisella tularensis

Amino acid biosynthesis

Serine family

IDP01160
(show subtarget assignments)

1

expressed

No

BA_4774

30259261

bacitracin ABC transporter, ATP-binding ...

307

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

25.7%

Bacillus anthracis

Transport and binding proteins

Other

IDP02300
(show subtarget assignments)

1

soluble

No

GBAA1860

47527151

alpha/beta fold family hydrolase [Bacill...

307

Drug target motif; Involved in sporulation;

Phase 3: June 2008

3HJU

26.7%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01135
(show subtarget assignments)

1

expressed

No

BA_3911

30258425

renal dipeptidase family protein

307

Drug Target Function

Phase 2: March 2008

3LU2

45.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02227
(show subtarget assignments)

1

cloned

No

FTT1063

56708148

hemF

coproporphyrinogen III oxidase [Francise...

308

Drug Target

Phase 3: June 2008

1VJU

51.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP91938
(show subtarget assignments)

8

selected

No

SpneCM_010100009513

298255813

cell division ABC transporter, permease ...

308

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP02000
(show subtarget assignments)

1

cloned

No

YPO0008

16120361

rbsK

ribokinase [Yersinia pestis CO92]

308

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1GQT

70.5%

Yersinia pestis

Energy metabolism

Pentose phosphate pathway

IDP91196
(show subtarget assignments)

8

soluble

No

BAS4097

49187095

-

Stage III sporulation protein AA

308

essential/virulence/pathogenesis / Essential proteins

Community Requests

Bacillus anthracis

IDP05685
(show subtarget assignments)

1

soluble

No

lmo1426

16803466

opuCC

hypothetical protein lmo1426 [Listeria m...

308

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PPN

57.1%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP00796
(show subtarget assignments)

0

work_stopped

No

SACOL1244

57285984

fabD

malonyl CoA-acyl carrier protein transac...

308

Drug Target Function

Phase 2: March 2008

3IM9

98.7%

Staphylococcus aureus

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01609
(show subtarget assignments)

1

crystallized

No

FTT1512c

56708550

dnaJ1

heat shock protein, hsp40 [Francisella t...

308

Conserved; Drug target functions

Phase 3: June 2008

3LZ8

34.2%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP00769
(show subtarget assignments)

0

work_stopped

No

SACOL0472

57285499

superantigen-like protein

308

Virulence Associated Factor

Phase 2: March 2008

3URY

60.7%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00746
(show subtarget assignments)

1

purified

No

SACOL1717

57284728

hemC

porphobilinogen deaminase

308

Drug Target Function

Phase 2: March 2008

1PDA

45.1%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02833
(show subtarget assignments)

1

cloned

No

GBAA4561

47529857

aroE

shikimate 5-dehydrogenase [Bacillus anth...

308

Conserved; Drug target functions

Phase 3: June 2008

2EGG

49.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP05406
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0669

30254269

rbsB

ribose ABC transporter, ribose-binding p...

308

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IOY

51.9%

Bacillus anthracis

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP02751
(show subtarget assignments)

1

expressed

No

FTT0634

56707759

hflC

SPFH domain-containing protein/band 7 fa...

308

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3BK6

13.6%

Francisella tularensis

Protein fateRegulatory functions

Degradation of proteins, peptides, and glycopeptidesProtein interactions

IDP02710
(show subtarget assignments)

1

in_pdb
3LU2

No

lmo2462

16804500

hypothetical protein lmo2462 [Listeria m...

308

Presence of Protease Motifs; DNA binding Motifs

Phase 3: June 2008

3LU2

100%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02598
(show subtarget assignments)

1

cloned

No

Cj1429c

15792747

hypothetical protein Cj1429c [Campylobac...

308

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04436
(show subtarget assignments)

1

expressed

No

YPCD1.97c

5832512

YPCD1.97c

putative transposase [Yersinia pestis CO...

308

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP01126
(show subtarget assignments)

1

cloned

No

BA_5392

47115756

HPr kinase/phosphorylase (HPrK/P) (HPr(S...

309

Conserved Gene / Pathway

Phase 2: March 2008

1KO7

59.2%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00559
(show subtarget assignments)

1

purified

No

YPO3032

16123209

hemF

coproporphyrinogen III oxidase

309

Conserved Gene / Pathway

Phase 2: March 2008

3E8J

59.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90501
(show subtarget assignments)

8

purified

No

Q9KP66

22257009

RecName: Full=Aspartate carbamoyltransfe...

309

Predicted Essential

Community Requests

2BE7

77.7%

Vibrio cholerae

IDP92029
(show subtarget assignments)

8

selected

No

TGME49_018920

237842737

proteasome subunit beta type 5, putative...

309

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3NZJ

42.7%

Toxoplasma gondii

IDP00108
(show subtarget assignments)

1

purified

No

NT01SF4751

30043076

fdhE

FdhE protein

309

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FIY

39.5%

Shigella flexneri

Central intermediary metabolism

Other

IDP00956
(show subtarget assignments)

1

in_pdb
3H0P

No

STM1194

16764549

fabD

acyl carrier protein S-malonyltransferas...

309

potential drug target / Essential Gene

Phase 2: March 2008

3H0P

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00025
(show subtarget assignments)

1

purified

No

BA_0285

30253779

bacitracin ABC transporter, ATP-binding ...

309

Virulence

Phase 1: October 2007

1OXS

30.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP05696
(show subtarget assignments)

1

expressed

No

lmo2170

16804209

-

hypothetical protein lmo2170 [Listeria m...

309

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3BO9

48.9%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP01720
(show subtarget assignments)

1

cloned

No

Cj1128c

15792453

wlaD

general glycosylation pathway protein [C...

309

Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...

Phase 3: June 2008

3BCV

16.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01663
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4696

47529995

hemC

porphobilinogen deaminase [Bacillus anth...

309

Conserved; Drug target functions

Phase 3: June 2008

1AH5

46.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP91827
(show subtarget assignments)

8

soluble

No

b1723

1788017

pfkB

6-phosphofructokinase II [Escherichia co...

309

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

3CQD

100%

Escherichia coli

IDP00426
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1598

16121866

fabD

acyl carrier protein S-malonyltransferas...

309

Conserved Gene / Pathway

Phase 2: March 2008

3H0P

79.3%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01614
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2581

16122794

putative sugar-binding periplasmic prote...

309

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2IOY

29.5%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04720
(show subtarget assignments)

1

expressed

No

YPO1174

115346948

hypothetical protein [Yersinia pestis CO...

309

virulence factor; putative drug target function;

Phase 4: April 2009

3ULT

12.6%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00042
(show subtarget assignments)

1

soluble

No

BA_2507

30257134

bla1

beta-lactamase

309

Virulence

Phase 1: October 2007

3QHY

87.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP05756
(show subtarget assignments)

1

cloned

No

lmo0814

16802856

-

hypothetical protein lmo0814 [Listeria m...

309

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3BO9

50.2%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP04017
(show subtarget assignments)

1

cloned

No

CPF_1035

110799411

putative lipoprotein [Clostridium perfri...

309

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP00733
(show subtarget assignments)

1

selected

No

SACOL2419

57285149

hlgA

gamma-hemolysin, component A

309

Conserved Gene / Pathway

Phase 2: March 2008

2QK7

90.9%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP91385
(show subtarget assignments)

8

soluble

No

VV1_1465

27364849

pyrB

aspartate carbamoyltransferase catalytic...

309

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2BE7

76.4%

Vibrio vulnificus

IDP91248
(show subtarget assignments)

8

soluble

No

HP0090

2313169

malonyl coenzyme A-acyl carrier protein ...

309

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2H1Y

98.1%

Helicobacter pylori

Fatty acid and phospholipid metabolism: Biosynthesis

IDP90686
(show subtarget assignments)

8

crystallized

No

Cj0918c

15792247

prsA

ribose-phosphate pyrophosphokinase [Camp...

309

Predicted Essential

Community Requests

3DAH

57.1%

Campylobacter jejuni

IDP05514
(show subtarget assignments)

1

purified

No

CD1315

126698913

ribC

riboflavin biosynthesis protein [Clostri...

309

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1MRZ

32.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP04422
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4023

47529316

pyrD

dihydroorotate dehydrogenase 1B [Bacillu...

309

putative drug target function;

Phase 4: April 2009

1EP1

68%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04304
(show subtarget assignments)

1

cloned

No

CPF_2640

110798722

sensor histidine kinase [Clostridium per...

310

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

23.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP90552
(show subtarget assignments)

8

soluble

No

YPO0058

16120411

rfaD

ADP-L-glycero-D-mannoheptose-6-epimerase...

310

Predicted Essential

Community Requests

1EQ2

82.3%

Yersinia pestis

IDP91419
(show subtarget assignments)

8

in_pdb
4E0B

No

VV1_0673

27364130

malate dehydrogenase [Vibrio vulnificus ...

310

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

4E0B

100%

Vibrio vulnificus

IDP05286
(show subtarget assignments)

1

cloned

No

CD0232

126697803

flgL

flagellar hook-associated protein [Clost...

310

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3PWX

17.1%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP92089
(show subtarget assignments)

8

selected

No

TGME49_118320

237840947

ATP-dependent Clp protease proteolytic s...

310

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3QWD

21.9%

Toxoplasma gondii

IDP92000
(show subtarget assignments)

8

selected

No

SpneCM_010100010043

298255919

membrane protein [Streptococcus pneumoni...

310

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3UB1

17.7%

Streptococcus pneumoniae

IDP05123
(show subtarget assignments)

1

soluble

No

BA_3845

30258363

conserved domain protein [Bacillus anthr...

310

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Domain

IDP04296
(show subtarget assignments)

1

selected

No

YPO2556

218929642

hexA

LysR-family transcriptional regulatory p...

310

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3ONM

70.6%

Yersinia pestis

Regulatory functions

Other

IDP91249
(show subtarget assignments)

8

soluble

No

NT01LM0800

16410126

lmo0737

lmo0737 [Listeria monocytogenes]

310

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP02673
(show subtarget assignments)

1

expressed

No

STM4466

16767711

carbamate kinase [Salmonella typhimurium...

310

Conserved; Drug target functions

Phase 3: June 2008

1E19

45.5%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP91739
(show subtarget assignments)

8

selected

No

Q6V4K9_STRPY

0

310

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2XNX

17.1%

Streptococcus pyogenes

IDP02508
(show subtarget assignments)

1

cloned

No

lmo1847

16803887

hypothetical protein lmo1847 [Listeria m...

310

Known virulence-Invasion; PMID:12496198

Phase 3: June 2008

1PSZ

52.3%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP01219
(show subtarget assignments)

1

purified

No

BA_3767

30258283

prophage LambdaBa01, N-acetylmuramoyl-L-...

310

Drug Target Function

Phase 2: March 2008

2L47

40.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90090
(show subtarget assignments)

8

expressed

No

ZZZ_0006

310

This protein is a component of a type VI secretion system of enteroaggregative E...

Community Requests

Escherichia coli

IDP01192
(show subtarget assignments)

1

purified

No

BA_1184

34098435

3-oxoacyl-[acyl-carrier-protein] synthas...

310

Drug Target Function

Phase 2: March 2008

1ZOW

61%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04488
(show subtarget assignments)

1

expressed

No

YPO3685

115349305

yhcQ

putative HlyD family secretion protein [...

311

conserved gene; putative drug target function;

Phase 4: April 2009

2F1M

17%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP05585
(show subtarget assignments)

1

soluble

No

Z0801

12513558

ybeK

putative tRNA synthetase [Escherichia co...

311

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1YOE

99.4%

Escherichia coli

Protein synthesis: tRNA aminoacylation

IDP90587
(show subtarget assignments)

8

in_pdb
3LXM

Yes

YPO3588

16123730

pyrB

aspartate carbamoyltransferase catalytic...

311

Predicted Essential

Community Requests

3LXM

100%

Yersinia pestis

IDP91867
(show subtarget assignments)

8

selected

No

SUB0057

222152254

DNA-binding protein [Streptococcus uberi...

311

Proteins of the ComR family of Rgg regulators are important for horiz...

Community Requests

Streptococcus uberis

IDP04682
(show subtarget assignments)

1

cloned

No

GBAA3189

47528481

adhesion lipoprotein [Bacillus anthracis...

311

virulence factor; putative drug target function;

Phase 4: April 2009

3HH8

49.8%

Bacillus anthracis

Cell envelope

Other

IDP01382
(show subtarget assignments)

1

cloned

No

VC0533

15640555

lipoprotein NlpD

311

Drug Target Function

Phase 2: March 2008

1QWY

24.1%

Vibrio cholerae

Cell envelope

Other

IDP91091
(show subtarget assignments)

8

cloned

No

APL_0387

126096663

kpsF

arabinose-5-phosphate isomerase [Actinob...

311

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

27%

Actinobacillus pleuropneumoniae

IDP04371
(show subtarget assignments)

1

expressed

No

GBAA4776

47778322

sensor histidine kinase [Bacillus anthra...

311

putative drug target function;

Phase 4: April 2009

2C2A

19.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01149
(show subtarget assignments)

1

purified

No

BA_1195

30254908

oligopeptide ABC transporter, ATP-bindin...

311

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

30.2%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP90832
(show subtarget assignments)

8

in_pdb
3R9U

Yes

Cj0146c

15791534

trxB

thioredoxin-disulfide reductase [Campylo...

312

Predicted Essential

Community Requests

3R9U

100%

Campylobacter jejuni

IDP02039
(show subtarget assignments)

1

expressed

No

YPO1198

16121491

putative ABC transport ATP-binding subun...

312

Conserved; CD; Drug target functions

Phase 3: June 2008

1V43

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02013
(show subtarget assignments)

1

cloned

No

STM2395

16765721

pgtE

outer membrane protease [Salmonella typh...

312

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

2X55

69.9%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02007
(show subtarget assignments)

1

in_crystallization_trials

No

STM2330

16765657

lrhA

NADH dehydrogenase transcriptional repre...

312

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3ONM

38.8%

Salmonella enterica

Energy metabolism

Aerobic

IDP00951
(show subtarget assignments)

1

in_pdb
3PP8
3KBO

No

STM1135

16764491

ycdW

putative oxidoreductase

312

Conserved Gene / Pathway

Phase 2: March 2008

3KBO

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP05606
(show subtarget assignments)

1

crystal_structure

No

BA_4837

30259338

mdh

malate dehydrogenase [Bacillus anthracis...

312

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TL2

100%

Bacillus anthracis

Energy metabolism: TCA cycle

IDP00902
(show subtarget assignments)

1

expressed

No

STM0045

16763435

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Conserved Gene / Pathway

Phase 2: March 2008

1MRZ

33%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP05398
(show subtarget assignments)

1

soluble

No

BA_3750

30258269

putative phosphonate ABC transporter, ph...

312

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3N5L

21.8%

Bacillus anthracis

Transport and binding proteins: Other

IDP90654
(show subtarget assignments)

8

expressed

No

YPO0474

16120803

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Predicted Essential

Community Requests

1MRZ

32.1%

Yersinia pestis

IDP01440
(show subtarget assignments)

1

in_pdb
3HJV

No

VC2022

15642024

acyl carrier protein S-malonyltransferas...

312

Drug Target Function

Phase 2: March 2008

3HJV

100%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP91276
(show subtarget assignments)

8

soluble

No

NT05BA4392

49181134

ribosomal protein L11 methyltransferase ...

312

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3GRZ

26.9%

Bacillus anthracis

Protein synthesis: Ribosomal proteins: synthesis and modification

IDP01415
(show subtarget assignments)

1

in_crystallization_trials

No

VC1363

15641375

siroheme synthase component enzyme

312

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

29.6%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00353
(show subtarget assignments)

1

in_crystallization_trials

No

lmo2202

16804241

3-oxoacyl-(acyl carrier protein) synthas...

312

Drug Target Function

Phase 2: March 2008

1ZOW

58.1%

Listeria monocytogenes

Fatty acid and phospholipid metabolism

Biosynthesis

IDP91610
(show subtarget assignments)

8

in_crystallization_trials

No

BAB37977

13364029

ECs4554

EspB protein [Escherichia coli O157:H7 s...

312

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP91814
(show subtarget assignments)

8

soluble

No

b3236

1789632

mdh

malate dehydrogenase, NAD(P)-binding [Es...

312

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

2PWZ

100%

Escherichia coli

IDP05721
(show subtarget assignments)

1

expressed

No

BA_2686

30257298

hypothetical protein BA_2686 [Bacillus a...

312

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis