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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 28 of 60, showing 100 records out of 5973 total, starting on record 2701
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP04482
(
show subtarget assignments
)
1
in_pdb
3P2A
Yes
YPO3270
218930295
trxC
thioredoxin 2 [Yersinia pestis CO92]
145
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3P2A
100%
Yersinia pestis
Energy metabolism
Electron transport
IDP02779
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT1405c
56708453
gloB
hydroxyacylglutathione hydrolase [Franci...
252
Conserved; Drug target functions
Phase 3: June 2008
2QED
34.1%
Francisella tularensis
Energy metabolism
Other
IDP02772
(
show subtarget assignments
)
1
purified
No
STM2649
16765969
trxC
thioredoxin 2 [Salmonella typhimurium LT...
139
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
3P2A
76.3%
Salmonella enterica
Energy metabolism
Electron transport
IDP02770
(
show subtarget assignments
)
1
cloned
No
GBAA2774
47528065
acoC
branched-chain alpha-keto acid dehydroge...
398
Essential; Drug target functions
Phase 3: June 2008
3DUF
33.2%
Bacillus anthracis
Energy metabolism
Fermentation
IDP02769
(
show subtarget assignments
)
1
cloned
No
FTT0304c
56707457
nfnB
dihydropteridine reductase [Francisella ...
217
Drug Target
Phase 3: June 2008
3HZN
45.6%
Francisella tularensis
Energy metabolism
Electron transport
IDP02760
(
show subtarget assignments
)
1
in_pdb
4EHJ
No
FTT1367c
56708420
pgk
phosphogylcerate kinase [Francisella tul...
392
Conserved; Drug target functions
Phase 3: June 2008
4EHJ
100%
Francisella tularensis
Energy metabolism
Glycolysis/gluconeogenesis
IDP02755
(
show subtarget assignments
)
1
expressed
No
FTT1365c
56708418
fbaB
fructose-1,6-bisphosphate aldolase [Fran...
354
Conserved; Drug target functions
Phase 3: June 2008
3GAK
46.6%
Francisella tularensis
Energy metabolism
Glycolysis/gluconeogenesis
IDP02745
(
show subtarget assignments
)
1
cloned
No
GBAA4384
47529679
bfmbAa
3-methyl-2-oxobutanoate dehydrogenase, a...
333
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
1UM9
41.7%
Bacillus anthracis
Energy metabolism
Amino acids and amines
IDP02744
(
show subtarget assignments
)
1
cloned
No
FTT0087
56707265
acnA
aconitate hydratase [Francisella tularen...
937
Drug Target
Phase 3: June 2008
3SN2
50.5%
Francisella tularensis
Energy metabolism
TCA cycle
IDP02743
(
show subtarget assignments
)
1
cloned
No
GBAA4383
47529678
bfmbAb
3-methyl-2-oxobutanoate dehydrogenase, b...
327
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
1UM9
52.9%
Bacillus anthracis
Energy metabolism
Amino acids and amines
IDP02734
(
show subtarget assignments
)
1
cloned
No
GBAA1779
47527069
thioredoxin family protein [Bacillus ant...
184
Drug target motif; Drug target functions
Phase 3: June 2008
1ST9
27.7%
Bacillus anthracis
Energy metabolism
Electron transport
IDP02733
(
show subtarget assignments
)
1
in_pdb
3M5P
3Q7I
3Q88
3LJK
Yes
FTT1315c
56708372
pgi
glucose-6-phosphate isomerase [Francisel...
540
Conserved; Drug target functions
Phase 3: June 2008
3LJK
99.8%
Francisella tularensis
Energy metabolism
Glycolysis/gluconeogenesis
IDP04463
(
show subtarget assignments
)
1
cloned
No
YPO1959
115347684
narR
nitrate/nitrite sensor protein [Yersinia...
593
conserved gene; putative drug target function;
Phase 4: April 2009
3EZH
8.4%
Yersinia pestis
Energy metabolism
Anaerobic
IDP02723
(
show subtarget assignments
)
1
cloned
No
FTT0039
56707219
nuoI
NADH dehydrogenase subunit I [Francisell...
162
Conserved; Drug target functions
Phase 3: June 2008
2FUG
33.3%
Francisella tularensis
Energy metabolism
Electron transport
IDP04722
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1357
115347116
ltaA
L-allo-threonine aldolase [Yersinia pest...
339
conserved gene; putative drug target function;
Phase 4: April 2009
1LW4
46.5%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP02717
(
show subtarget assignments
)
1
cloned
No
GBAA3854
47529142
chi36
extracellular exochitinase Chi36 [Bacill...
360
Drug target motif; Involved in sporulation; Drug target functions
Phase 3: June 2008
3N11
88.6%
Bacillus anthracis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP02711
(
show subtarget assignments
)
1
cloned
No
GBAA5551
47530871
atpF
F0F1 ATP synthase subunit B [Bacillus an...
168
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
Bacillus anthracis
Energy metabolism
ATP-proton motive force interconversion
IDP00346
(
show subtarget assignments
)
1
cloned
No
lmo0489
16802532
hypothetical protein lmo0489
664
Drug Target Function
Phase 2: March 2008
3K30
26.6%
Listeria monocytogenes
Energy metabolism
Electron transport
IDP04721
(
show subtarget assignments
)
1
expressed
No
YPO1289
115347051
conserved hypothetical protein [Yersinia...
380
conserved gene; putative drug target function;
Phase 4: April 2009
2Q18
16.8%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP02703
(
show subtarget assignments
)
1
crystallized
No
GBAA3432
47528718
tkt-1
transketolase [Bacillus anthracis str. '...
674
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3HYL
58.1%
Bacillus anthracis
Energy metabolism
Pentose phosphate pathway
IDP02700
(
show subtarget assignments
)
1
cloned
No
YPO3419
16123568
aceE
pyruvate dehydrogenase subunit E1 [Yersi...
887
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1L8A
89.1%
Yersinia pestis
Energy metabolism
Pyruvate dehydrogenase
IDP02696
(
show subtarget assignments
)
1
soluble
No
GBAA2773
47528064
acoL
dihydrolipoamide dehydrogenase [Bacillus...
459
Conserved; Drug target functions
Phase 3: June 2008
2QAE
40.6%
Bacillus anthracis
Energy metabolism
Fermentation
IDP02697
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA3029
47528319
succinylornithine transaminase, putative...
405
Conserved; Essential; Drug target functions
Phase 3: June 2008
2E54
37.5%
Bacillus anthracis
Energy metabolism
Amino acids and amines
IDP02692
(
show subtarget assignments
)
1
expressed
No
FTT0503c
56707642
sucD
succinyl-CoA synthetase, alpha subunit [...
290
Conserved; Drug target functions
Phase 3: June 2008
1CQI
75.5%
Francisella tularensis
Energy metabolism
TCA cycle
IDP00700
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL2656
57286560
arcB2
ornithine carbamoyltransferase
336
Drug Target Function
Phase 2: March 2008
2W37
63.3%
Staphylococcus aureus
Energy metabolism
Amino acids and amines
IDP02688
(
show subtarget assignments
)
0
work_stopped
No
YPO0921
16121226
pgk
phosphoglycerate kinase [Yersinia pestis...
387
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1ZMR
88.6%
Yersinia pestis
Energy metabolism
Glycolysis/gluconeogenesis
IDP02685
(
show subtarget assignments
)
1
cloned
No
Cj1027c
15792354
gyrA
DNA gyrase subunit A [Campylobacter jeju...
863
Predicted virulence-Resistance to antibiotics and toxic compounds
Phase 3: June 2008
2WL2
33%
Campylobacter jejuni
Energy metabolism
Electron transport
IDP01371
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC0250
15640280
iron-containing alcohol dehydrogenase fa...
374
Conserved Gene / Pathway
Phase 2: March 2008
3OWO
28.3%
Vibrio cholerae
Energy metabolism
Fermentation
IDP02673
(
show subtarget assignments
)
1
expressed
No
STM4466
16767711
carbamate kinase [Salmonella typhimurium...
310
Conserved; Drug target functions
Phase 3: June 2008
1E19
45.5%
Salmonella enterica
Energy metabolism
Amino acids and amines
IDP02668
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA1526
47526800
gpsA
NAD(P)H-dependent glycerol-3-phosphate d...
340
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
1Z82
42.9%
Bacillus anthracis
Energy metabolism
Other
IDP04464
(
show subtarget assignments
)
1
purified
No
YPO1972
218929084
hutI
imidazolonepropionase [Yersinia pestis C...
406
conserved gene; putative drug target function;
Phase 4: April 2009
2OOF
54.9%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP02664
(
show subtarget assignments
)
1
purified
No
GBAA5387
47778397
trxB
thioredoxin reductase [Bacillus anthraci...
318
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
2Q7V
47.5%
Bacillus anthracis
Energy metabolism
Electron transport
IDP04462
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1939
115347664
putative glutaminase [Yersinia pestis CO...
340
putative drug target function;
Phase 4: April 2009
1U60
38.2%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP02653
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM2840
16766146
anaerobic nitric oxide reductase flavoru...
479
Conserved; Drug target functions
Phase 3: June 2008
1YCF
33.8%
Salmonella enterica
Energy metabolism
Electron transport
IDP02648
(
show subtarget assignments
)
1
soluble
No
FTT0064
56707243
atpD
F0F1 ATP synthase subunit beta [Francise...
458
Conserved; Drug target functions
Phase 3: June 2008
3OAA
81.3%
Francisella tularensis
Energy metabolism
ATP-proton motive force interconversion
IDP02647
(
show subtarget assignments
)
1
in_crystallization_trials
No
lmo0537
16802580
allantoate amidohydrolase [Listeria mono...
423
Presence of Protease Motifs; DNA binding Motifs
Phase 3: June 2008
3N5F
38.1%
Listeria monocytogenes
Energy metabolism
Amino acids and amines
IDP02645
(
show subtarget assignments
)
1
soluble
No
STM1749
16765093
adhE
bifunctional acetaldehyde-CoA/alcohol de...
892
Conserved; Essential; Drug target functions
Phase 3: June 2008
3MY7
38.7%
Salmonella enterica
Energy metabolism
Fermentation
IDP02644
(
show subtarget assignments
)
1
purified
No
FTT0074
56707253
sdhA
succinate dehydrogenase, catalytic and N...
597
Conserved; Drug target functions
Phase 3: June 2008
1NEK
61.4%
Francisella tularensis
Energy metabolism
TCA cycle
IDP02643
(
show subtarget assignments
)
1
in_pdb
3RUY
No
GBAA1154
47526421
rocD
ornithine--oxo-acid transaminase [Bacill...
396
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3RUY
98.7%
Bacillus anthracis
Energy metabolism
Amino acids and amines
IDP02642
(
show subtarget assignments
)
1
cloned
No
GBAA5626
47778419
4-oxalocrotonate tautomerase [Bacillus a...
61
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
2OP8
78.7%
Bacillus anthracis
Energy metabolism
Other
IDP02640
(
show subtarget assignments
)
1
purified
No
GBAA0609
47525887
aspA
aspartate ammonia-lyase [Bacillus anthra...
477
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1J3U
70.6%
Bacillus anthracis
Energy metabolism
Amino acids and amines
IDP00686
(
show subtarget assignments
)
1
purified
No
SACOL2029
57284899
cscA
sucrose-6-phosphate hydrolase
494
Drug Target Function
Phase 2: March 2008
1UYP
29.8%
Staphylococcus aureus
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP04295
(
show subtarget assignments
)
1
cloned
No
FTT0031
56707211
nuoA
NADH dehydrogenase I, A subunit [Francis...
132
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3RKO
33.3%
Francisella tularensis
Energy metabolism
Electron transport
IDP02638
(
show subtarget assignments
)
1
in_pdb
3LG3
No
YPO3725
16123862
aceA
isocitrate lyase [Yersinia pestis CO92]
435
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
3LG3
100%
Yersinia pestis
Energy metabolism
TCA cycle
IDP01344
(
show subtarget assignments
)
1
crystallized
No
VCA1025
15601778
nagB
glucosamine-6-phosphate deaminase
266
Drug Target Function
Phase 2: March 2008
1CD5
79.3%
Vibrio cholerae
Energy metabolism
Sugars
IDP02618
(
show subtarget assignments
)
1
cloned
No
STM2205
16765535
fruK
1-phosphofructokinase [Salmonella typhim...
312
Conserved; Drug target functions
Phase 3: June 2008
3CQD
31.1%
Salmonella enterica
Energy metabolism
Glycolysis/gluconeogenesis
IDP02599
(
show subtarget assignments
)
1
cloned
No
Cj1138
15792463
putative galactosyltransferase [Campylob...
389
Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...
Phase 3: June 2008
3L7I
22%
Campylobacter jejuni
Energy metabolism
Sugars
IDP02596
(
show subtarget assignments
)
1
cloned
No
GBAA1269
47526536
odhB
dihydrolipoamide acetyltransferase [Baci...
418
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3DUF
38.1%
Bacillus anthracis
Energy metabolism
TCA cycle
IDP01332
(
show subtarget assignments
)
1
purified
No
VC0639
15640659
phosphoglucomutase/phosphomannomutase fa...
446
Drug Target Function
Phase 2: March 2008
3PDK
46.6%
Vibrio cholerae
Energy metabolism
Sugars
IDP02594
(
show subtarget assignments
)
1
soluble
No
STM1539
16764884
putative hydrogenase-1 small subunit [Sa...
367
Conserved; Drug target functions
Phase 3: June 2008
3RGW
66.8%
Salmonella enterica
Energy metabolism
Electron transport
IDP02592
(
show subtarget assignments
)
1
expressed
No
GBAA1308
47526573
glycolate oxidase, iron-sulfur subunit, ...
442
Conserved; Drug target functions
Phase 3: June 2008
Bacillus anthracis
Energy metabolism
Other
IDP04683
(
show subtarget assignments
)
1
expressed
No
GBAA3269
47528557
iron-sulfur cluster-binding protein [Bac...
470
virulence factor; putative drug target function;
Phase 4: April 2009
Bacillus anthracis
Energy metabolism
Electron transport
IDP01329
(
show subtarget assignments
)
1
in_pdb
3HJB
No
VC0374
15640401
pgi
glucose-6-phosphate isomerase
550
Drug Target Function
Phase 2: March 2008
3HJB
99.8%
Vibrio cholerae
Energy metabolism
Glycolysis/gluconeogenesis
IDP04685
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA3438
47528724
alcohol dehydrogenase, zinc-containing [...
335
virulence factor; putative drug target function;
Phase 4: April 2009
3GAZ
37.3%
Bacillus anthracis
Energy metabolism
Fermentation
IDP04283
(
show subtarget assignments
)
1
expressed
No
YPO1971
218929083
hutG
putative N-formylglutamate amidohydrolas...
268
conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP02577
(
show subtarget assignments
)
1
purified
No
GBAA5546
47530866
atpC
F0F1 ATP synthase subunit epsilon [Bacil...
133
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
2E5Y
69.9%
Bacillus anthracis
Energy metabolism
ATP-proton motive force interconversion
IDP02575
(
show subtarget assignments
)
1
cloned
No
GBAA5123
47778366
glgB
glycogen branching enzyme [Bacillus anth...
645
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3K1D
43.4%
Bacillus anthracis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP04681
(
show subtarget assignments
)
1
soluble
No
GBAA3131
47528422
adhB
alcohol dehydrogenase, zinc-containing [...
377
virulence factor; putative drug target function;
Phase 4: April 2009
1KOL
31.9%
Bacillus anthracis
Energy metabolism
Fermentation
IDP01319
(
show subtarget assignments
)
1
soluble
No
VC0312
15640339
fre
FMN reductase
236
Conserved Gene / Pathway
Phase 2: March 2008
1QFJ
48.3%
Vibrio cholerae
Energy metabolism
Electron transport
IDP01316
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC1616
15641624
glutaredoxin, putative
77
Conserved Gene / Pathway
Phase 2: March 2008
2KLX
32.5%
Vibrio cholerae
Energy metabolism
Electron transport
IDP02561
(
show subtarget assignments
)
1
purified
No
FTT0714c
56707833
kbl
2-amino-3-ketobutyrate coenzyme A ligase...
398
Conserved; Drug target functions
Phase 3: June 2008
1FC4
62.1%
Francisella tularensis
Energy metabolism
Amino acids and amines
IDP00328
(
show subtarget assignments
)
1
in_pdb
3UHP
3UHF
3UHO
No
Cj1652c
15792957
murI
glutamate racemase
250
Drug Target Function
Phase 2: March 2008
2JFX
53.7%
Campylobacter jejuni
Energy metabolism
Pentose phosphate pathway
IDP02553
(
show subtarget assignments
)
1
cloned
No
Cj1293
15792616
polysaccharide biosynthesis protein [Cam...
334
Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...
Phase 3: June 2008
2GN4
63.5%
Campylobacter jejuni
Energy metabolism
Glycolysis/gluconeogenesis
IDP01308
(
show subtarget assignments
)
1
expressed
No
VC1516
15641524
iron-sulfur cluster-binding protein
553
Conserved Gene / Pathway
Phase 2: March 2008
Vibrio cholerae
Energy metabolism
Electron transport
IDP02542
(
show subtarget assignments
)
1
in_pdb
3INP
No
FTT0789
56707900
rpe
D-ribulose-phosphate 3-epimerase [Franci...
222
Drug Target
Phase 3: June 2008
3INP
100%
Francisella tularensis
Energy metabolism
Pentose phosphate pathway
IDP02539
(
show subtarget assignments
)
1
cloned
No
YPO3200
16123361
malZ
maltodextrin glucosidase [Yersinia pesti...
609
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1EA9
33.5%
Yersinia pestis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP01303
(
show subtarget assignments
)
1
purified
No
VC0573
15640595
ubiquinol--cytochrome c reductase, iron-...
197
Conserved Gene / Pathway
Phase 2: March 2008
2FYN
37.6%
Vibrio cholerae
Energy metabolism
Electron transport
IDP00001
(
show subtarget assignments
)
1
cloned
No
BA_4599
30259099
aldehyde-alcohol dehydrogenase
867
Drug Target Homolog
Phase 1: October 2007
3MY7
24.5%
Bacillus anthracis
Energy metabolism
Fermentation
IDP02533
(
show subtarget assignments
)
1
expressed
No
GBAA4184
47529480
pdhA
pyruvate dehydrogenase complex E1 compon...
371
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3DUF
80.9%
Bacillus anthracis
Energy metabolism
Pyruvate dehydrogenase
IDP02526
(
show subtarget assignments
)
1
cloned
No
FTT1600c
56708620
fumA
fumerate hydratase [Francisella tularens...
504
Drug Target
Phase 3: June 2008
2ISB
13.7%
Francisella tularensis
Energy metabolism
TCA cycle
IDP02519
(
show subtarget assignments
)
1
cloned
No
GBAA1494
47526768
resA
thiol-disulfide oxidoreductase [Bacillus...
173
Conserved; Drug target functions
Phase 3: June 2008
1ST9
41.6%
Bacillus anthracis
Energy metabolism
Electron transport
IDP02515
(
show subtarget assignments
)
1
cloned
No
YPO2567
16122785
pta
phosphate acetyltransferase [Yersinia pe...
717
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...
Phase 3: June 2008
1TD9
20.6%
Yersinia pestis
Energy metabolism
Fermentation
IDP04454
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1254
218928409
bglA
6-phospho-beta-glucosidase [Yersinia pes...
478
drug target; putative drug target function;
Phase 4: April 2009
2XHY
77.8%
Yersinia pestis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP02496
(
show subtarget assignments
)
1
expressed
No
GBAA4183
47529479
pdhB
pyruvate dehydrogenase complex E1 compon...
325
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3DUF
85.8%
Bacillus anthracis
Energy metabolism
Pyruvate dehydrogenase
IDP02490
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA3974
47529264
sucC
succinyl-CoA synthetase subunit beta [Ba...
386
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1CQI
54.7%
Bacillus anthracis
Energy metabolism
TCA cycle
IDP04280
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1108
115346887
gltA
citrate synthase GltA [Yersinia pestis C...
426
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
1K3P
86.6%
Yersinia pestis
Energy metabolism
TCA cycle
IDP02480
(
show subtarget assignments
)
1
cloned
No
GBAA5700
47531036
galE-2
UDP-glucose 4-epimerase [Bacillus anthra...
338
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3ENK
58.6%
Bacillus anthracis
Energy metabolism
Sugars
IDP02478
(
show subtarget assignments
)
1
cloned
No
GBAA4182
47529478
pdhC
branched-chain alpha-keto acid dehydroge...
419
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3DUF
74.7%
Bacillus anthracis
Energy metabolism
Pyruvate dehydrogenase
IDP02472
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO3785
16123919
hypothetical protein YPO3785 [Yersinia p...
276
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
1YWF
26.2%
Yersinia pestis
Energy metabolism
Sugars
IDP02470
(
show subtarget assignments
)
1
purified
No
lmo0865
16802906
hypothetical protein lmo0865 [Listeria m...
557
Predicted involvement in glycosyl group metabolism; DNA binding Motifs
Phase 3: June 2008
1TUO
26.2%
Listeria monocytogenes
Energy metabolism
Sugars
IDP02466
(
show subtarget assignments
)
1
crystallized
No
YPO1771
16122025
L-serine dehydratase [Yersinia pestis CO...
454
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...
Phase 3: June 2008
2IQQ
17%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP04450
(
show subtarget assignments
)
1
cloned
No
YPO0905
218928078
gcvP
glycine dehydrogenase [Yersinia pestis C...
959
conserved gene; putative drug target function;
Phase 4: April 2009
1WYT
19.1%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP02454
(
show subtarget assignments
)
1
in_pdb
3HYL
3M49
No
GBAA3744
47529034
tkt-2
transketolase [Bacillus anthracis str. '...
666
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3HYL
100%
Bacillus anthracis
Energy metabolism
Pentose phosphate pathway
IDP01218
(
show subtarget assignments
)
1
expressed
No
BA_3712
73919984
Histidine ammonia-lyase (Histidase)
505
Drug Target Function
Phase 2: March 2008
1GK2
42%
Bacillus anthracis
Energy metabolism
Amino acids and amines
IDP02450
(
show subtarget assignments
)
1
expressed
No
FTT1475
56708515
galT
galactose-1-phosphate uridylyltransferas...
341
Drug Target
Phase 3: June 2008
1HXQ
51.6%
Francisella tularensis
Energy metabolism
Sugars
IDP02436
(
show subtarget assignments
)
1
cloned
No
Cj1418c
15792736
hypothetical protein Cj1418c [Campylobac...
779
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
Campylobacter jejuni
Energy metabolism
Electron transport
IDP02429
(
show subtarget assignments
)
1
expressed
No
FTT0723c
56707841
Short-chain dehydrogenase/reductase fami...
262
Conserved; Drug target functions
Phase 3: June 2008
4E3Z
35.9%
Francisella tularensis
Energy metabolism
Other
IDP02425
(
show subtarget assignments
)
1
soluble
No
GBAA2775
47528067
acoB
TPP-dependent acetoin dehydrogenase E1 b...
344
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
1W85
43.9%
Bacillus anthracis
Energy metabolism
Fermentation
IDP00019
(
show subtarget assignments
)
1
cloned
No
BA_4843
30259344
pykA-2
pyruvate kinase
585
Drug Target Homolog
Phase 1: October 2007
2E28
69.6%
Bacillus anthracis
Energy metabolism
Glycolysis/gluconeogenesis
IDP02417
(
show subtarget assignments
)
1
cloned
No
FTT0812
56707923
gcvH1
glycine cleavage system protein H [Franc...
126
Conserved; Drug target functions
Phase 3: June 2008
1ZKO
40.5%
Francisella tularensis
Energy metabolism
Amino acids and amines
IDP02412
(
show subtarget assignments
)
1
soluble
No
GBAA4760
47530059
etfB
electron transfer flavoprotein, beta sub...
257
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1EFP
38.2%
Bacillus anthracis
Energy metabolism
Electron transport
IDP02409
(
show subtarget assignments
)
1
in_crystallization_trials
No
Cj0883c
15792214
hypothetical protein Cj0883c [Campylobac...
136
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
2Y75
28.7%
Campylobacter jejuni
Energy metabolism
Electron transport
IDP02406
(
show subtarget assignments
)
1
crystallized
No
GBAA2768
47528059
thioredoxin reductase, putative [Bacillu...
301
Conserved; Essential; Drug target functions
Phase 3: June 2008
3FBS
32.1%
Bacillus anthracis
Energy metabolism
Electron transport
IDP02389
(
show subtarget assignments
)
1
cloned
No
lmo0232
16802278
clpC
endopeptidase Clp ATP-binding chain C [L...
820
Known virulence-Invasion; PMID:11083831; Presence of Protease Motifs
Phase 3: June 2008
3PXI
72.8%
Listeria monocytogenes
Energy metabolism
ATP-proton motive force interconversion
IDP02383
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0489c
56707631
trxB
thioredoxin reductase [Francisella tular...
316
Drug Target
Phase 3: June 2008
1CL0
66.8%
Francisella tularensis
Energy metabolism
Electron transport
IDP02374
(
show subtarget assignments
)
1
purified
No
GBAA3116
47528407
ppsA
phosphoenolpyruvate synthase [Bacillus a...
868
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
2OLS
15.7%
Bacillus anthracis
Energy metabolism
Glycolysis/gluconeogenesis
IDP02372
(
show subtarget assignments
)
1
in_pdb
3P7M
No
FTT0535c
56707668
mdh
lactate dehydrogenase [Francisella tular...
319
Conserved; Drug target functions
Phase 3: June 2008
3P7M
100%
Francisella tularensis
Energy metabolism
TCA cycle
IDP00615
(
show subtarget assignments
)
1
expressed
No
SACOL1160
57284445
sdhB
succinate dehydrogenase iron-sulfur subu...
271
Conserved Gene / Pathway
Phase 2: March 2008
1E7P
25.1%
Staphylococcus aureus
Energy metabolism
TCA cycle
IDP02363
(
show subtarget assignments
)
1
purified
No
FTT1366c
56708419
pyk
pyruvate kinase [Francisella tularensis ...
478
Conserved; Drug target functions
Phase 3: June 2008
1E0U
39.5%
Francisella tularensis
Energy metabolism
Glycolysis/gluconeogenesis
IDP02362
(
show subtarget assignments
)
1
cloned
No
GBAA1923
47777980
ldh
L-lactate dehydrogenase [Bacillus anthra...
314
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3PQD
64.6%
Bacillus anthracis
Energy metabolism
Anaerobic
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Filter Columns
Filter Columns:
Target Id
Locus Tag
Priority
Stage
Has Screening
Ncbi Gi
Gene Name
Common Name
Length
Justification
Project
Homolog Pdb Id
Homolog Sequence Identity
Organism
Tigr Main Role
Tigr Sub Role
