Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04196 (show subtarget assignments)	1	cloned	No	CPF_2502	110800817		putative lipoprotein [Clostridium perfri...	507	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04197 (show subtarget assignments)	1	expressed	No	CPF_2510	110799662		putative lipoprotein [Clostridium perfri...	237	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04198 (show subtarget assignments)	1	soluble	No	CPF_2555	110799167		oligopeptide/dipeptide ABC transporter, ...	580	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XOC	29.8%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP04199 (show subtarget assignments)	1	cloned	No	CPF_2557	110800712	guaA	bifunctional GMP synthase/glutamine amid...	509	conserved gene; putative drug target function;	Phase 4: April 2009	1GPM	52.3%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04200 (show subtarget assignments)	1	expressed	No	CPF_0244	110798897		putative lipoprotein [Clostridium perfri...	440	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04201 (show subtarget assignments)	1	expressed	No	CPF_0499	110800753		sensor histidine kinase [Clostridium per...	431	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP04202 (show subtarget assignments)	1	cloned	No	CPF_2277	110798838		putative stage IV sporulation protein [C...	378	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04203 (show subtarget assignments)	1	selected	No	CPF_2298	110800865	gpr	germination protease [Clostridium perfri...	325	conserved gene; putative drug target function;	Phase 4: April 2009	1C8B	42.3%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04204 (show subtarget assignments)	1	soluble	No	CPF_2382	110799414	obgE	GTPase ObgE [Clostridium perfringens ATC...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1LNZ	44.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04205 (show subtarget assignments)	1	soluble	No	CPF_2805	110801373	spoVT	stage V sprulation protein T [Clostridiu...	182	conserved gene; putative drug target function;	Phase 4: April 2009	2W1T	63.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04206 (show subtarget assignments)	1	cloned	No	CPF_2812	110799133	prsA	ribose-phosphate pyrophosphokinase [Clos...	319	conserved gene; putative drug target function;	Phase 4: April 2009	1DKR	63%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04207 (show subtarget assignments)	1	soluble	No	CPF_2836	110801144		putative lipoprotein [Clostridium perfri...	279	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04208 (show subtarget assignments)	1	purified	No	CPF_2958	110799195	purA	adenylosuccinate synthetase [Clostridium...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1IWE	47.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04209 (show subtarget assignments)	1	soluble	No	Z5142	15804250		hypothetical protein Z5142 [Escherichia ...	398	Effector protein	Phase 4: April 2009	3PCR	89.7%	Escherichia coli

IDP04210 (show subtarget assignments)	1	expressed	No	ZZZ_0017				243	Effector protein	Phase 4: April 2009	2KXC	18.5%	Escherichia coli

IDP04211 (show subtarget assignments)	1	expressed	No	STM0408_1_323	16763788	secF	preprotein translocase subunit SecF [Sal...	323	Salmonella essential protein	Phase 4: April 2009	3AQP	35.3%	Salmonella enterica

IDP04212 (show subtarget assignments)	1	cloned	No	STM0646_1_343	16764023	holA	DNA polymerase III subunit delta [Salmon...	343	Salmonella essential protein	Phase 4: April 2009	1JQJ	89.8%	Salmonella enterica

IDP04213 (show subtarget assignments)	1	cloned	No	STM1003_1_478	16764363		putative transcriptional regulator [Salm...	478	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04214 (show subtarget assignments)	1	expressed	No	STM1473_1_377	16764819	ompN	outer membrane protein N precursor [Salm...	377	Salmonella essential protein	Phase 4: April 2009	1OSM	66%	Salmonella enterica

IDP04215 (show subtarget assignments)	1	cloned	No	STM1574_1_495	16764918	smvA	methyl viologen resistance [Salmonella t...	495	Salmonella essential protein	Phase 4: April 2009	2GFP	17%	Salmonella enterica

IDP04216 (show subtarget assignments)	1	cloned	No	STM1894_1_336	16765236	ruvB	Holliday junction DNA helicase B [Salmon...	336	Salmonella essential protein	Phase 4: April 2009	1HQC	53%	Salmonella enterica

IDP04217 (show subtarget assignments)	1	cloned	No	STM2619_1_203	16765939		hypothetical protein STM2619 [Salmonella...	203	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04218 (show subtarget assignments)	1	expressed	No	STM2996_1_1123	16766298	recC	exonuclease V subunit gamma [Salmonella ...	1123	Salmonella essential protein	Phase 4: April 2009	1W36	88.4%	Salmonella enterica

IDP04219 (show subtarget assignments)	1	cloned	No	STM3148_1_392	16766448	hybB	putative hydrogenase 2 b cytochrome subu...	392	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04221 (show subtarget assignments)	1	expressed	No	STM4262_1_688	16767512		putative ABC-type bacteriocin/lantibioti...	688	Salmonella essential protein	Phase 4: April 2009	3G5U	21.5%	Salmonella enterica

IDP04222 (show subtarget assignments)	8	selected	No	CAC05827	12329096	spa33	Spa33, component of the Mxi-Spa secretio...	293	Shigella effector protein	Community Requests			Shigella flexneri

IDP04223 (show subtarget assignments)	8	selected	No	CAC05808	12329077	ipgD	IpgD, secreted by the Mxi-Spa machinery,...	538	Shigella effector protein	Community Requests			Shigella flexneri

IDP04224 (show subtarget assignments)	8	selected	No	CAC05802	12329071	ipaC	IpaC, secreted by the Mxi-Spa secretion ...	363	Shigella effector protein	Community Requests			Shigella flexneri

IDP04225 (show subtarget assignments)	8	cloned	No	CAC05803	12329072	ipaB	IpaB, secreted by the Mxi-Spa secretion ...	580	Shigella effector protein	Community Requests	3U0C	34.3%	Shigella flexneri

IDP04226 (show subtarget assignments)	1	cloned	No	CPF_0171	110799571	luxS	S-ribosylhomocysteinase [Clostridium per...	151	conserved gene; putative drug target function;	Phase 4: April 2009	1J6W	51%	Clostridium perfringens	Cellular processes	Other

IDP04227 (show subtarget assignments)	1	expressed	No	CPF_0198	110799765		sensory box histidine kinase [Clostridiu...	791	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.6%	Clostridium perfringens	Regulatory functions

IDP04228 (show subtarget assignments)	1	cloned	No	CPF_0675	110800755	purM	phosphoribosylaminoimidazole synthetase ...	333	conserved gene; putative drug target function;	Phase 4: April 2009	2BTU	54.9%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04229 (show subtarget assignments)	1	purified	No	CPF_0676	110798651	purN	phosphoribosylglycinamide formyltransfer...	204	conserved gene; putative drug target function;	Phase 4: April 2009	2YWR	42.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04230 (show subtarget assignments)	1	purified	No	CPF_0678	110801134	purD	phosphoribosylamine--glycine ligase [Clo...	416	conserved gene; putative drug target function;	Phase 4: April 2009	2YW2	51.1%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04231 (show subtarget assignments)	1	purified	No	CPF_0690	110800421	aroC	chorismate synthase [Clostridium perfrin...	357	conserved gene; putative drug target function;	Phase 4: April 2009	1UM0	39.8%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP04232 (show subtarget assignments)	1	cloned	No	CPF_0693	110799915	aroE	shikimate 5-dehydrogenase [Clostridium p...	271	conserved gene; putative drug target function;	Phase 4: April 2009	3FBT	46.9%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP04233 (show subtarget assignments)	1	cloned	No	CPF_0722	110798767		putative lipoprotein [Clostridium perfri...	384	drug target; putative drug target function;	Phase 4: April 2009	2UVK	16.1%	Clostridium perfringens	Cell envelope	Other

IDP04234 (show subtarget assignments)	1	cloned	No	CPF_0807	110799166		iron compound ABC transporter, iron comp...	314	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HXP	29.3%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04235 (show subtarget assignments)	1	cloned	No	CPF_0823	110800089		polysaccharide deacetylase family protei...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W3Z	32.1%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04236 (show subtarget assignments)	1	expressed	No	CPF_0837	110799475		sensor histidine kinase [Clostridium per...	336	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.9%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04237 (show subtarget assignments)	1	purified	No	CPF_0863	110800564		putative sensor histidine kinase [Clostr...	420	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.7%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04238 (show subtarget assignments)	1	cloned	No	CPF_0889	110799788		sensor histidine kinase [Clostridium per...	475	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP04239 (show subtarget assignments)	1	cloned	No	CPF_1057	110799811		sensor histidine kinase [Clostridium per...	418	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.4%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04240 (show subtarget assignments)	1	cloned	No	CPF_1077	110800997		extracellular solute-binding protein [Cl...	477	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W7Y	15.3%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04241 (show subtarget assignments)	1	soluble	No	CPF_1112	110801022		sensor histidine kinase [Clostridium per...	574	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Regulatory functions	Protein interactions

IDP04242 (show subtarget assignments)	1	cloned	No	CPF_1113	110798641		sugar ABC transporter, sugar-binding pro...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3QUF	22.9%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04243 (show subtarget assignments)	1	soluble	No	CPF_1140	110799522		sensor histidine kinase [Clostridium per...	418	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.7%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04244 (show subtarget assignments)	1	soluble	No	CPF_1171	110801284		sensor histidine kinase [Clostridium per...	410	conserved gene; putative drug target function;	Phase 4: April 2009	1B3Q	9.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04245 (show subtarget assignments)	1	cloned	No	CPF_1193	110801261		bacitracin ABC transporter, ATP-binding ...	306	conserved gene; putative drug target function;	Phase 4: April 2009	1VPL	27.5%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04246 (show subtarget assignments)	1	cloned	No	CPF_1362	110799745		aluminum resistance protein [Clostridium...	426	conserved gene; putative drug target function;	Phase 4: April 2009	3GWP	71.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04247 (show subtarget assignments)	1	expressed	No	CPF_1402	110798994		sensor histidine kinase [Clostridium per...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.3%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04248 (show subtarget assignments)	1	in_pdb 4EDP	No	CPF_1477	110800354		ABC transporter, substrate-binding prote...	348	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EDP	100%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04249 (show subtarget assignments)	1	expressed	No	CPF_1548	110800969		putative galactoside ABC transporter, ga...	354	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GLG	50.6%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04250 (show subtarget assignments)	1	cloned	No	BAS2213	49185222		DNA-binding protein HU [Bacillus anthrac...	90	Proposed to be essential proteins	Phase 4: April 2009	3RHI	78.9%	Bacillus anthracis

IDP04251 (show subtarget assignments)	1	cloned	No	CPF_1751	110801372	virS	sensor histidine kinase VirS [Clostridiu...	440	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04252 (show subtarget assignments)	1	cloned	No	CPF_1780	110799805		putative lipoprotein [Clostridium perfri...	445	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04253 (show subtarget assignments)	1	purified	No	CPF_1800	110800480	prs	phosphoribosylpyrophosphate synthetase [...	364	conserved gene; putative drug target function;	Phase 4: April 2009	2C4K	25.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04254 (show subtarget assignments)	1	cloned	No	CPF_1823	110798846		putative lipoprotein [Clostridium perfri...	233	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04255 (show subtarget assignments)	1	cloned	No	CPF_1922	110799469	purB	adenylosuccinate lyase [Clostridium perf...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2J91	56.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04256 (show subtarget assignments)	1	purified	No	CPF_2006	110801043	spoIVA	stage IV sporulation protein A [Clostrid...	491	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04257 (show subtarget assignments)	1	cloned	No	CPF_2008	110798819	engA	GTP-binding protein EngA [Clostridium pe...	438	conserved gene; putative drug target function;	Phase 4: April 2009	2HJG	54.3%	Clostridium perfringens	Cellular processes	Cell division

IDP04258 (show subtarget assignments)	1	soluble	No	CPF_2010	110801347		sensory box histidine kinase [Clostridiu...	571	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	17.3%	Clostridium perfringens	Regulatory functions

IDP04259 (show subtarget assignments)	1	cloned	No	CPF_2018	110799691	ftsZ	cell division protein FtsZ [Clostridium ...	381	conserved gene; putative drug target function;	Phase 4: April 2009	2VAM	58%	Clostridium perfringens	Cellular processes	Cell division

IDP04260 (show subtarget assignments)	1	cloned	No	CPF_2020	110798885	pilT	twitching motility protein PilT [Clostri...	350	conserved gene; putative drug target function;	Phase 4: April 2009	2EWV	49.1%	Clostridium perfringens	Cellular processes	Chemotaxis and motility

IDP04261 (show subtarget assignments)	1	cloned	No	CPF_2059	110798854	scpB	segregation and condensation protein B [...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1T6S	28.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04262 (show subtarget assignments)	1	cloned	No	CPF_2067	110799430	spo0A	Spo0A protein [Clostridium perfringens A...	276	conserved gene; putative drug target function;	Phase 4: April 2009	1LQ1	31.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04263 (show subtarget assignments)	1	cloned	No	CPF_2068	110800995		stage IV sporulation protein B [Clostrid...	386	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04264 (show subtarget assignments)	1	cloned	No	CPF_2101	110800507		fibronectin-binding protein [Clostridium...	575	conserved gene; putative drug target function;	Phase 4: April 2009	3DOA	17.7%	Clostridium perfringens	Cellular processes

IDP04265 (show subtarget assignments)	1	purified	No	CPF_2105	110800754		putative cell division protein DivIVA [C...	208	conserved gene; putative drug target function;	Phase 4: April 2009	2WUJ	12%	Clostridium perfringens	Cellular processes	Cell division

IDP04266 (show subtarget assignments)	1	cloned	No	CPF_2122	110798774	pdaA	delta-lactam-biosynthetic de-N-acetylase...	265	conserved gene; putative drug target function;	Phase 4: April 2009	2J13	41.5%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04267 (show subtarget assignments)	1	cloned	No	CPF_2134	110799922	spoVD	stage V sporulation protein D [Clostridi...	727	conserved gene; putative drug target function;	Phase 4: April 2009	1RP5	26.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04268 (show subtarget assignments)	1	soluble	No	CPF_2184	110799943	glyA	serine hydroxymethyltransferase [Clostri...	410	conserved gene; putative drug target function;	Phase 4: April 2009	3PGY	68.3%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04269 (show subtarget assignments)	1	cloned	No	CPF_2193	110798612	relA	GTP pyrophosphokinase [Clostridium perfr...	726	conserved gene; putative drug target function;	Phase 4: April 2009	1VJ7	28.1%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04270 (show subtarget assignments)	1	cloned	No	CPF_2226	110799081	potD	spermidine/putrescine ABC transporter, s...	360	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EQB	40.3%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP04271 (show subtarget assignments)	1	expressed	No	CPF_2241	110798635		sensor histidine kinase [Clostridium per...	678	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	12.4%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04272 (show subtarget assignments)	1	expressed	No	GBAA3899	47529188		lantibiotic biosynthesis sensor histidin...	453	putative drug target function;	Phase 4: April 2009	2C2A	14.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04273 (show subtarget assignments)	1	cloned	No	YPCD1.23	5832444	YPCD1.23	hypothetical protein YPCD1.23 [Yersinia ...	139	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04274 (show subtarget assignments)	1	cloned	No	YPCD1.49	16082737	virF	transcriptional regulator [Yersinia pest...	271	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	3OIO	11.8%	Yersinia pestis	Regulatory functions	Other

IDP04275 (show subtarget assignments)	1	cloned	No	BAS3684	49186683		DNA topoisomerase I [Bacillus anthracis ...	692	Proposed to be essential proteins	Phase 4: April 2009	2GAI	38.2%	Bacillus anthracis

IDP04276 (show subtarget assignments)	1	soluble	No	FTT0312c	56707465	folA	dihydrofolate reductase type I [Francise...	166	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3JW3	41.6%	Francisella tularensis

IDP04277 (show subtarget assignments)	1	cloned	No	BAS3960	49186958		PTS system, glucose-specific IIABC compo...	687	Proposed to be essential proteins	Phase 4: April 2009	1AX3	14.7%	Bacillus anthracis

IDP04278 (show subtarget assignments)	1	soluble	No	YPO0504	115346313		conserved hypothetical protein [Yersinia...	614	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04279 (show subtarget assignments)	1	expressed	No	YPO0260	218927465		putative AraC-family regulatory protein ...	206	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	3OIO	16.5%	Yersinia pestis	Regulatory functions	Other

IDP04280 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1108	115346887	gltA	citrate synthase GltA [Yersinia pestis C...	426	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1K3P	86.6%	Yersinia pestis	Energy metabolism	TCA cycle

IDP04281 (show subtarget assignments)	1	cloned	No	YPO1150	115346925	bioA	adenosylmethionine-8-amino-7-oxononanoat...	422	conserved gene; putative drug target function;	Phase 4: April 2009	1MLY	73.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04282 (show subtarget assignments)	1	selected	No	YPO1465	115347219		conserved hypothetical protein [Yersinia...	166	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04283 (show subtarget assignments)	1	expressed	No	YPO1971	218929083	hutG	putative N-formylglutamate amidohydrolas...	268	conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04284 (show subtarget assignments)	1	cloned	No	YPO0808	218927988		general secretion pathway protein L [Yer...	389	putative drug target function;	Phase 4: April 2009	1W97	13.1%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04285 (show subtarget assignments)	1	expressed	No	YPO0809	218927989		general secretion pathway protein K [Yer...	318	putative drug target function;	Phase 4: April 2009	3CI0	18.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04287 (show subtarget assignments)	1	cloned	No	YPO2703	115348386	pcp	putative pyrrolidone-carboxylate peptida...	215	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3LAC	54%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04288 (show subtarget assignments)	1	expressed	No	YPCD1.08c	5832431	YPCD1.08c	hypothetical protein YPCD1.08c [Yersinia...	99	virulence factor; conserved gene;	Phase 4: April 2009	3KXE	28.3%	Yersinia pestis

IDP04289 (show subtarget assignments)	1	expressed	No	YPCD1.35c	16082723	yscY	hypothetical protein YPCD1.35c [Yersinia...	114	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04290 (show subtarget assignments)	1	cloned	No	YPO3099	218930141	manC	mannose-1-phosphate guanylyltransferase ...	470	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2CU2	28.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides

IDP04291 (show subtarget assignments)	1	expressed	No	YPO3603	115349224		putative exported protein [Yersinia pest...	1177	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Unclassified	Role category not yet assigned

IDP04292 (show subtarget assignments)	1	cloned	No	YPO0812	218927992		general secretion pathway protein H [Yer...	180	conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04293 (show subtarget assignments)	1	in_pdb 3OXP	Yes	YPO2569	218929655		phosphotransferase enzyme II, A componen...	147	conserved gene; putative drug target function;	Phase 4: April 2009	3OXP	100%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP04294 (show subtarget assignments)	1	cloned	No	YPO3477	115349102		putative lipid carrier protein [Yersinia...	173	conserved gene; putative drug target function;	Phase 4: April 2009	1C44	13.3%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04295 (show subtarget assignments)	1	cloned	No	FTT0031	56707211	nuoA	NADH dehydrogenase I, A subunit [Francis...	132	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RKO	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP04296 (show subtarget assignments)	1	selected	No	YPO2556	218929642	hexA	LysR-family transcriptional regulatory p...	310	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3ONM	70.6%	Yersinia pestis	Regulatory functions	Other

IDP04297 (show subtarget assignments)	1	in_pdb 4EG2	No	VC1231	15641244		cytidine deaminase [Vibrio cholerae O1 b...	295	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EG2	100%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP04196
(show subtarget assignments)

1

cloned

No

CPF_2502

110800817

putative lipoprotein [Clostridium perfri...

507

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04197
(show subtarget assignments)

1

expressed

No

CPF_2510

110799662

putative lipoprotein [Clostridium perfri...

237

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04198
(show subtarget assignments)

1

soluble

No

CPF_2555

110799167

oligopeptide/dipeptide ABC transporter, ...

580

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XOC

29.8%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP04199
(show subtarget assignments)

1

cloned

No

CPF_2557

110800712

guaA

bifunctional GMP synthase/glutamine amid...

509

conserved gene; putative drug target function;

Phase 4: April 2009

1GPM

52.3%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04200
(show subtarget assignments)

1

expressed

No

CPF_0244

110798897

putative lipoprotein [Clostridium perfri...

440

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04201
(show subtarget assignments)

1

expressed

No

CPF_0499

110800753

sensor histidine kinase [Clostridium per...

431

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP04202
(show subtarget assignments)

1

cloned

No

CPF_2277

110798838

putative stage IV sporulation protein [C...

378

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04203
(show subtarget assignments)

1

selected

No

CPF_2298

110800865

gpr

germination protease [Clostridium perfri...

325

conserved gene; putative drug target function;

Phase 4: April 2009

1C8B

42.3%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04204
(show subtarget assignments)

1

soluble

No

CPF_2382

110799414

obgE

GTPase ObgE [Clostridium perfringens ATC...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1LNZ

44.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04205
(show subtarget assignments)

1

soluble

No

CPF_2805

110801373

spoVT

stage V sprulation protein T [Clostridiu...

182

conserved gene; putative drug target function;

Phase 4: April 2009

2W1T

63.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04206
(show subtarget assignments)

1

cloned

No

CPF_2812

110799133

prsA

ribose-phosphate pyrophosphokinase [Clos...

319

conserved gene; putative drug target function;

Phase 4: April 2009

1DKR

63%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04207
(show subtarget assignments)

1

soluble

No

CPF_2836

110801144

putative lipoprotein [Clostridium perfri...

279

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04208
(show subtarget assignments)

1

purified

No

CPF_2958

110799195

purA

adenylosuccinate synthetase [Clostridium...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1IWE

47.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04209
(show subtarget assignments)

1

soluble

No

Z5142

15804250

hypothetical protein Z5142 [Escherichia ...

398

Effector protein

Phase 4: April 2009

3PCR

89.7%

Escherichia coli

IDP04210
(show subtarget assignments)

1

expressed

No

ZZZ_0017

243

Effector protein

Phase 4: April 2009

2KXC

18.5%

Escherichia coli

IDP04211
(show subtarget assignments)

1

expressed

No

STM0408_1_323

16763788

secF

preprotein translocase subunit SecF [Sal...

323

Salmonella essential protein

Phase 4: April 2009

3AQP

35.3%

Salmonella enterica

IDP04212
(show subtarget assignments)

1

cloned

No

STM0646_1_343

16764023

holA

DNA polymerase III subunit delta [Salmon...

343

Salmonella essential protein

Phase 4: April 2009

1JQJ

89.8%

Salmonella enterica

IDP04213
(show subtarget assignments)

1

cloned

No

STM1003_1_478

16764363

putative transcriptional regulator [Salm...

478

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04214
(show subtarget assignments)

1

expressed

No

STM1473_1_377

16764819

ompN

outer membrane protein N precursor [Salm...

377

Salmonella essential protein

Phase 4: April 2009

1OSM

66%

Salmonella enterica

IDP04215
(show subtarget assignments)

1

cloned

No

STM1574_1_495

16764918

smvA

methyl viologen resistance [Salmonella t...

495

Salmonella essential protein

Phase 4: April 2009

2GFP

17%

Salmonella enterica

IDP04216
(show subtarget assignments)

1

cloned

No

STM1894_1_336

16765236

ruvB

Holliday junction DNA helicase B [Salmon...

336

Salmonella essential protein

Phase 4: April 2009

1HQC

53%

Salmonella enterica

IDP04217
(show subtarget assignments)

1

cloned

No

STM2619_1_203

16765939

hypothetical protein STM2619 [Salmonella...

203

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04218
(show subtarget assignments)

1

expressed

No

STM2996_1_1123

16766298

recC

exonuclease V subunit gamma [Salmonella ...

1123

Salmonella essential protein

Phase 4: April 2009

1W36

88.4%

Salmonella enterica

IDP04219
(show subtarget assignments)

1

cloned

No

STM3148_1_392

16766448

hybB

putative hydrogenase 2 b cytochrome subu...

392

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04221
(show subtarget assignments)

1

expressed

No

STM4262_1_688

16767512

putative ABC-type bacteriocin/lantibioti...

688

Salmonella essential protein

Phase 4: April 2009

3G5U

21.5%

Salmonella enterica

IDP04222
(show subtarget assignments)

8

selected

No

CAC05827

12329096

spa33

Spa33, component of the Mxi-Spa secretio...

293

Shigella effector protein

Community Requests

Shigella flexneri

IDP04223
(show subtarget assignments)

8

selected

No

CAC05808

12329077

ipgD

IpgD, secreted by the Mxi-Spa machinery,...

538

Shigella effector protein

Community Requests

Shigella flexneri

IDP04224
(show subtarget assignments)

8

selected

No

CAC05802

12329071

ipaC

IpaC, secreted by the Mxi-Spa secretion ...

363

Shigella effector protein

Community Requests

Shigella flexneri

IDP04225
(show subtarget assignments)

8

cloned

No

CAC05803

12329072

ipaB

IpaB, secreted by the Mxi-Spa secretion ...

580

Shigella effector protein

Community Requests

3U0C

34.3%

Shigella flexneri

IDP04226
(show subtarget assignments)

1

cloned

No

CPF_0171

110799571

luxS

S-ribosylhomocysteinase [Clostridium per...

151

conserved gene; putative drug target function;

Phase 4: April 2009

1J6W

51%

Clostridium perfringens

Cellular processes

Other

IDP04227
(show subtarget assignments)

1

expressed

No

CPF_0198

110799765

sensory box histidine kinase [Clostridiu...

791

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.6%

Clostridium perfringens

Regulatory functions

IDP04228
(show subtarget assignments)

1

cloned

No

CPF_0675

110800755

purM

phosphoribosylaminoimidazole synthetase ...

333

conserved gene; putative drug target function;

Phase 4: April 2009

2BTU

54.9%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04229
(show subtarget assignments)

1

purified

No

CPF_0676

110798651

purN

phosphoribosylglycinamide formyltransfer...

204

conserved gene; putative drug target function;

Phase 4: April 2009

2YWR

42.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04230
(show subtarget assignments)

1

purified

No

CPF_0678

110801134

purD

phosphoribosylamine--glycine ligase [Clo...

416

conserved gene; putative drug target function;

Phase 4: April 2009

2YW2

51.1%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04231
(show subtarget assignments)

1

purified

No

CPF_0690

110800421

aroC

chorismate synthase [Clostridium perfrin...

357

conserved gene; putative drug target function;

Phase 4: April 2009

1UM0

39.8%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP04232
(show subtarget assignments)

1

cloned

No

CPF_0693

110799915

aroE

shikimate 5-dehydrogenase [Clostridium p...

271

conserved gene; putative drug target function;

Phase 4: April 2009

3FBT

46.9%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP04233
(show subtarget assignments)

1

cloned

No

CPF_0722

110798767

putative lipoprotein [Clostridium perfri...

384

drug target; putative drug target function;

Phase 4: April 2009

2UVK

16.1%

Clostridium perfringens

Cell envelope

Other

IDP04234
(show subtarget assignments)

1

cloned

No

CPF_0807

110799166

iron compound ABC transporter, iron comp...

314

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HXP

29.3%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04235
(show subtarget assignments)

1

cloned

No

CPF_0823

110800089

polysaccharide deacetylase family protei...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W3Z

32.1%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04236
(show subtarget assignments)

1

expressed

No

CPF_0837

110799475

sensor histidine kinase [Clostridium per...

336

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.9%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04237
(show subtarget assignments)

1

purified

No

CPF_0863

110800564

putative sensor histidine kinase [Clostr...

420

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.7%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04238
(show subtarget assignments)

1

cloned

No

CPF_0889

110799788

sensor histidine kinase [Clostridium per...

475

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP04239
(show subtarget assignments)

1

cloned

No

CPF_1057

110799811

sensor histidine kinase [Clostridium per...

418

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.4%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04240
(show subtarget assignments)

1

cloned

No

CPF_1077

110800997

extracellular solute-binding protein [Cl...

477

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W7Y

15.3%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04241
(show subtarget assignments)

1

soluble

No

CPF_1112

110801022

sensor histidine kinase [Clostridium per...

574

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04242
(show subtarget assignments)

1

cloned

No

CPF_1113

110798641

sugar ABC transporter, sugar-binding pro...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3QUF

22.9%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04243
(show subtarget assignments)

1

soluble

No

CPF_1140

110799522

sensor histidine kinase [Clostridium per...

418

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.7%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04244
(show subtarget assignments)

1

soluble

No

CPF_1171

110801284

sensor histidine kinase [Clostridium per...

410

conserved gene; putative drug target function;

Phase 4: April 2009

1B3Q

9.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04245
(show subtarget assignments)

1

cloned

No

CPF_1193

110801261

bacitracin ABC transporter, ATP-binding ...

306

conserved gene; putative drug target function;

Phase 4: April 2009

1VPL

27.5%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04246
(show subtarget assignments)

1

cloned

No

CPF_1362

110799745

aluminum resistance protein [Clostridium...

426

conserved gene; putative drug target function;

Phase 4: April 2009

3GWP

71.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04247
(show subtarget assignments)

1

expressed

No

CPF_1402

110798994

sensor histidine kinase [Clostridium per...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.3%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04248
(show subtarget assignments)

1

in_pdb
4EDP

No

CPF_1477

110800354

ABC transporter, substrate-binding prote...

348

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EDP

100%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04249
(show subtarget assignments)

1

expressed

No

CPF_1548

110800969

putative galactoside ABC transporter, ga...

354

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GLG

50.6%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04250
(show subtarget assignments)

1

cloned

No

BAS2213

49185222

DNA-binding protein HU [Bacillus anthrac...

90

Proposed to be essential proteins

Phase 4: April 2009

3RHI

78.9%

Bacillus anthracis

IDP04251
(show subtarget assignments)

1

cloned

No

CPF_1751

110801372

virS

sensor histidine kinase VirS [Clostridiu...

440

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04252
(show subtarget assignments)

1

cloned

No

CPF_1780

110799805

putative lipoprotein [Clostridium perfri...

445

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04253
(show subtarget assignments)

1

purified

No

CPF_1800

110800480

prs

phosphoribosylpyrophosphate synthetase [...

364

conserved gene; putative drug target function;

Phase 4: April 2009

2C4K

25.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04254
(show subtarget assignments)

1

cloned

No

CPF_1823

110798846

putative lipoprotein [Clostridium perfri...

233

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04255
(show subtarget assignments)

1

cloned

No

CPF_1922

110799469

purB

adenylosuccinate lyase [Clostridium perf...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2J91

56.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04256
(show subtarget assignments)

1

purified

No

CPF_2006

110801043

spoIVA

stage IV sporulation protein A [Clostrid...

491

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04257
(show subtarget assignments)

1

cloned

No

CPF_2008

110798819

engA

GTP-binding protein EngA [Clostridium pe...

438

conserved gene; putative drug target function;

Phase 4: April 2009

2HJG

54.3%

Clostridium perfringens

Cellular processes

Cell division

IDP04258
(show subtarget assignments)

1

soluble

No

CPF_2010

110801347

sensory box histidine kinase [Clostridiu...

571

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

17.3%

Clostridium perfringens

Regulatory functions

IDP04259
(show subtarget assignments)

1

cloned

No

CPF_2018

110799691

ftsZ

cell division protein FtsZ [Clostridium ...

381

conserved gene; putative drug target function;

Phase 4: April 2009

2VAM

58%

Clostridium perfringens

Cellular processes

Cell division

IDP04260
(show subtarget assignments)

1

cloned

No

CPF_2020

110798885

pilT

twitching motility protein PilT [Clostri...

350

conserved gene; putative drug target function;

Phase 4: April 2009

2EWV

49.1%

Clostridium perfringens

Cellular processes

Chemotaxis and motility

IDP04261
(show subtarget assignments)

1

cloned

No

CPF_2059

110798854

scpB

segregation and condensation protein B [...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1T6S

28.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04262
(show subtarget assignments)

1

cloned

No

CPF_2067

110799430

spo0A

Spo0A protein [Clostridium perfringens A...

276

conserved gene; putative drug target function;

Phase 4: April 2009

1LQ1

31.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04263
(show subtarget assignments)

1

cloned

No

CPF_2068

110800995

stage IV sporulation protein B [Clostrid...

386

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04264
(show subtarget assignments)

1

cloned

No

CPF_2101

110800507

fibronectin-binding protein [Clostridium...

575

conserved gene; putative drug target function;

Phase 4: April 2009

3DOA

17.7%

Clostridium perfringens

Cellular processes

IDP04265
(show subtarget assignments)

1

purified

No

CPF_2105

110800754

putative cell division protein DivIVA [C...

208

conserved gene; putative drug target function;

Phase 4: April 2009

2WUJ

12%

Clostridium perfringens

Cellular processes

Cell division

IDP04266
(show subtarget assignments)

1

cloned

No

CPF_2122

110798774

pdaA

delta-lactam-biosynthetic de-N-acetylase...

265

conserved gene; putative drug target function;

Phase 4: April 2009

2J13

41.5%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04267
(show subtarget assignments)

1

cloned

No

CPF_2134

110799922

spoVD

stage V sporulation protein D [Clostridi...

727

conserved gene; putative drug target function;

Phase 4: April 2009

1RP5

26.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04268
(show subtarget assignments)

1

soluble

No

CPF_2184

110799943

glyA

serine hydroxymethyltransferase [Clostri...

410

conserved gene; putative drug target function;

Phase 4: April 2009

3PGY

68.3%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04269
(show subtarget assignments)

1

cloned

No

CPF_2193

110798612

relA

GTP pyrophosphokinase [Clostridium perfr...

726

conserved gene; putative drug target function;

Phase 4: April 2009

1VJ7

28.1%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04270
(show subtarget assignments)

1

cloned

No

CPF_2226

110799081

potD

spermidine/putrescine ABC transporter, s...

360

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EQB

40.3%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP04271
(show subtarget assignments)

1

expressed

No

CPF_2241

110798635

sensor histidine kinase [Clostridium per...

678

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

12.4%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04272
(show subtarget assignments)

1

expressed

No

GBAA3899

47529188

lantibiotic biosynthesis sensor histidin...

453

putative drug target function;

Phase 4: April 2009

2C2A

14.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04273
(show subtarget assignments)

1

cloned

No

YPCD1.23

5832444

YPCD1.23

hypothetical protein YPCD1.23 [Yersinia ...

139

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04274
(show subtarget assignments)

1

cloned

No

YPCD1.49

16082737

virF

transcriptional regulator [Yersinia pest...

271

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

3OIO

11.8%

Yersinia pestis

Regulatory functions

Other

IDP04275
(show subtarget assignments)

1

cloned

No

BAS3684

49186683

DNA topoisomerase I [Bacillus anthracis ...

692

Proposed to be essential proteins

Phase 4: April 2009

2GAI

38.2%

Bacillus anthracis

IDP04276
(show subtarget assignments)

1

soluble

No

FTT0312c

56707465

folA

dihydrofolate reductase type I [Francise...

166

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3JW3

41.6%

Francisella tularensis

IDP04277
(show subtarget assignments)

1

cloned

No

BAS3960

49186958

PTS system, glucose-specific IIABC compo...

687

Proposed to be essential proteins

Phase 4: April 2009

1AX3

14.7%

Bacillus anthracis

IDP04278
(show subtarget assignments)

1

soluble

No

YPO0504

115346313

conserved hypothetical protein [Yersinia...

614

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04279
(show subtarget assignments)

1

expressed

No

YPO0260

218927465

putative AraC-family regulatory protein ...

206

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

3OIO

16.5%

Yersinia pestis

Regulatory functions

Other

IDP04280
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1108

115346887

gltA

citrate synthase GltA [Yersinia pestis C...

426

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1K3P

86.6%

Yersinia pestis

Energy metabolism

TCA cycle

IDP04281
(show subtarget assignments)

1

cloned

No

YPO1150

115346925

bioA

adenosylmethionine-8-amino-7-oxononanoat...

422

conserved gene; putative drug target function;

Phase 4: April 2009

1MLY

73.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04282
(show subtarget assignments)

1

selected

No

YPO1465

115347219

conserved hypothetical protein [Yersinia...

166

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04283
(show subtarget assignments)

1

expressed

No

YPO1971

218929083

hutG

putative N-formylglutamate amidohydrolas...

268

conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04284
(show subtarget assignments)

1

cloned

No

YPO0808

218927988

general secretion pathway protein L [Yer...

389

putative drug target function;

Phase 4: April 2009

1W97

13.1%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04285
(show subtarget assignments)

1

expressed

No

YPO0809

218927989

general secretion pathway protein K [Yer...

318

putative drug target function;

Phase 4: April 2009

3CI0

18.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04287
(show subtarget assignments)

1

cloned

No

YPO2703

115348386

pcp

putative pyrrolidone-carboxylate peptida...

215

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3LAC

54%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04288
(show subtarget assignments)

1

expressed

No

YPCD1.08c

5832431

YPCD1.08c

hypothetical protein YPCD1.08c [Yersinia...

99

virulence factor; conserved gene;

Phase 4: April 2009

3KXE

28.3%

Yersinia pestis

IDP04289
(show subtarget assignments)

1

expressed

No

YPCD1.35c

16082723

yscY

hypothetical protein YPCD1.35c [Yersinia...

114

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04290
(show subtarget assignments)

1

cloned

No

YPO3099

218930141

manC

mannose-1-phosphate guanylyltransferase ...

470

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2CU2

28.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

IDP04291
(show subtarget assignments)

1

expressed

No

YPO3603

115349224

putative exported protein [Yersinia pest...

1177

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04292
(show subtarget assignments)

1

cloned

No

YPO0812

218927992

general secretion pathway protein H [Yer...

180

conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04293
(show subtarget assignments)

1

in_pdb
3OXP

Yes

YPO2569

218929655

phosphotransferase enzyme II, A componen...

147

conserved gene; putative drug target function;

Phase 4: April 2009

3OXP

100%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP04294
(show subtarget assignments)

1

cloned

No

YPO3477

115349102

putative lipid carrier protein [Yersinia...

173

conserved gene; putative drug target function;

Phase 4: April 2009

1C44

13.3%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04295
(show subtarget assignments)

1

cloned

No

FTT0031

56707211

nuoA

NADH dehydrogenase I, A subunit [Francis...

132

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RKO

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP04296
(show subtarget assignments)

1

selected

No

YPO2556

218929642

hexA

LysR-family transcriptional regulatory p...

310

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3ONM

70.6%

Yersinia pestis

Regulatory functions

Other

IDP04297
(show subtarget assignments)

1

in_pdb
4EG2

No

VC1231

15641244

cytidine deaminase [Vibrio cholerae O1 b...

295

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EG2

100%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

Targets