Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01140 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4546	33301122		Germination protease precursor (Spore pr...	368	Drug Target Function	Phase 2: March 2008	1C8B	70.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90627 (show subtarget assignments)	8	selected	No	VC1239	15641252	cobU	adenosylcobinamide kinase/adenosylcobina...	179	Predicted Essential	Community Requests	1C9K	41.3%	Vibrio cholerae

IDP01102 (show subtarget assignments)	1	soluble	No	BA_5424	49040749		Cold shock-like protein cspC	65	Essential Gene	Phase 2: March 2008	1C9O	74.2%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP01344 (show subtarget assignments)	1	crystallized	No	VCA1025	15601778	nagB	glucosamine-6-phosphate deaminase	266	Drug Target Function	Phase 2: March 2008	1CD5	79.3%	Vibrio cholerae	Energy metabolism	Sugars

IDP04113 (show subtarget assignments)	1	selected	No	YPO2627	115348319	glmD	putative glucosamine-6-phosphate isomera...	266	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CD5	85.7%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP02331 (show subtarget assignments)	1	selected	No	GBAA2661	47527952	adP-1	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	30.7%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02566 (show subtarget assignments)	1	purified	No	GBAA3033	50196939	adP-2	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	31.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01967 (show subtarget assignments)	1	soluble	No	STM1789	16765130		hydrogenase 1 maturation protease [Salmo...	198	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1CFZ	30.8%	Salmonella enterica	Energy metabolism	Aerobic

IDP01909 (show subtarget assignments)	1	soluble	No	STM1536	16764881		putative hydrogenase maturation protease...	202	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1CFZ	30.7%	Salmonella enterica	Energy metabolism	Aerobic

IDP90502 (show subtarget assignments)	8	purified	No	Q9KPA4	22653875		RecName: Full=L-aspartate oxidase; Short...	535	Predicted Essential	Community Requests	1CHU	75.3%	Vibrio cholerae

IDP02607 (show subtarget assignments)	1	expressed	No	CBU_0101	29540723	nadB	L-aspartate oxidase [Coxiella burnetii R...	536	Conserved; Drug target functions	Phase 3: June 2008	1CHU	52.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP90902 (show subtarget assignments)	8	in_crystallization_trials	No	STM2641	16765961	nadB	L-aspartate oxidase [Salmonella typhimur...	540	Predicted Essential	Community Requests	1CHU	89.6%	Salmonella enterica

IDP05741 (show subtarget assignments)	1	purified	No	CD2371	126699986	nadB	L-aspartate oxidase [Clostridium diffici...	433	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1CHU	37%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP02753 (show subtarget assignments)	1	expressed	No	GBAA4662	47529960	nadB	L-aspartate oxidase [Bacillus anthracis ...	509	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1CHU	37.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP02462 (show subtarget assignments)	1	expressed	No	FTT1467c	56708507	nadB	L-aspartate oxidase [Francisella tularen...	495	Conserved; Drug target functions	Phase 3: June 2008	1CHU	38.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP90914 (show subtarget assignments)	8	purified	No	YPO2710	16122914	nadB	L-aspartate oxidase [Yersinia pestis CO9...	545	Predicted Essential	Community Requests	1CHU	82%	Yersinia pestis

IDP92057 (show subtarget assignments)	8	selected	No	TGME49_061030	237831917		mitochondrial NADPH:adrenodoxin oxidored...	656	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1CJC	25%	Toxoplasma gondii

IDP04640 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0559c	56707689	cmk	cytidylate kinase [Francisella tularensi...	221	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CKE	47.1%	Francisella tularensis

IDP90888 (show subtarget assignments)	8	in_crystallization_trials	No	Q9KQT2	22001682		RecName: Full=Cytidylate kinase; Short=C...	225	Predicted Essential	Community Requests	1CKE	70.2%	Vibrio cholerae

IDP02383 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0489c	56707631	trxB	thioredoxin reductase [Francisella tular...	316	Drug Target	Phase 3: June 2008	1CL0	66.8%	Francisella tularensis	Energy metabolism	Electron transport

IDP90913 (show subtarget assignments)	8	soluble	No	VC1182	15641195		thioredoxin reductase [Vibrio cholerae O...	318	Predicted Essential	Community Requests	1CL0	81.4%	Vibrio cholerae

IDP02353 (show subtarget assignments)	1	soluble	No	YPO1374	16121654	trxB	thioredoxin reductase [Yersinia pestis C...	320	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1CL0	85%	Yersinia pestis	Energy metabolism	Electron transport

IDP02250 (show subtarget assignments)	1	soluble	No	YPO0278	16120617	metC	cystathionine beta-lyase [Yersinia pesti...	393	Involved in virulence; Drug target functions	Phase 3: June 2008	1CL2	42.2%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP04124 (show subtarget assignments)	1	crystallized	No	YPO2828	218929893	purI	phosphoribosylaminoimidazole synthetase ...	347	conserved gene; putative drug target function;	Phase 4: April 2009	1CLI	81.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01989 (show subtarget assignments)	1	purified	No	STM2646	16765966	yfiD	autonomous glycyl radical cofactor GrcA ...	127	Conserved; Drug target functions	Phase 3: June 2008	1CM5	38.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP90991 (show subtarget assignments)	8	cloned	No	y1282	22125182		formate acetyltransferase [Yersinia pest...	150	other biological interest / stress-response protein replacind PflA in PflA/PflB complex	Community Requests	1CM5	40%	Yersinia pestis

IDP04444 (show subtarget assignments)	1	soluble	No	YPO0532	115346340	leuB	3-isopropylmalate dehydrogenase [Yersini...	365	conserved gene; putative drug target function;	Phase 4: April 2009	1CM7	85.5%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP02136 (show subtarget assignments)	1	purified	No	YPO0114	16120460	metJ	transcriptional repressor protein MetJ [...	105	Involved in virulence; Drug target functions	Phase 3: June 2008	1CMA	88.6%	Yersinia pestis	Regulatory functions	DNA interactions

IDP91431 (show subtarget assignments)	8	cloned	No	VV1_0489	27363953		Trp operon repressor [Vibrio vulnificus ...	102	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1CO0	46.1%	Vibrio vulnificus

IDP02405 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1803c	56708789	trpR	trp operon repressor [Francisella tulare...	95	Drug Target	Phase 3: June 2008	1CO0	30.5%	Francisella tularensis	Amino acid biosynthesisRegulatory functions	Aromatic amino acid familyDNA interactions

IDP90612 (show subtarget assignments)	8	soluble	No	NMPDR 243277.1.peg.3916				281	Predicted Essential	Community Requests	1COZ	17.1%	Vibrio cholerae

IDP90676 (show subtarget assignments)	8	expressed	No	Cj0533	15791894	sucC	succinyl-CoA synthase, beta subunit [Cam...	387	Predicted Essential	Community Requests	1CQI	45.5%	Campylobacter jejuni

IDP02187 (show subtarget assignments)	1	purified	No	FTT0504c	56707643	sucC	succinyl-CoA synthetase subunit beta [Fr...	387	Conserved; Drug target functions	Phase 3: June 2008	1CQI	62.8%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02490 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3974	47529264	sucC	succinyl-CoA synthetase subunit beta [Ba...	386	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1CQI	54.7%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP02692 (show subtarget assignments)	1	expressed	No	FTT0503c	56707642	sucD	succinyl-CoA synthetase, alpha subunit [...	290	Conserved; Drug target functions	Phase 3: June 2008	1CQI	75.5%	Francisella tularensis	Energy metabolism	TCA cycle

IDP00644 (show subtarget assignments)	1	expressed	No	SACOL0220	57286684		flavohemoprotein, putative	381	Conserved Gene / Pathway	Phase 2: March 2008	1CQX	36.9%	Staphylococcus aureus	Unknown function	General

IDP90910 (show subtarget assignments)	8	soluble	No	VC2390	15642387		carbamoyl phosphate synthase small subun...	379	Predicted Essential	Community Requests	1CS0	82.3%	Vibrio cholerae

IDP00610 (show subtarget assignments)	1	cloned	No	SACOL1437	57286088		cold shock protein, CSD family	66	Conserved Gene / Pathway	Phase 2: March 2008	1CSP	75.8%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP01111 (show subtarget assignments)	1	cloned	No	BA_1135	49035527		Major cold shock protein cspA	67	Conserved Gene / Pathway	Phase 2: March 2008	1CSP	73.1%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP02245 (show subtarget assignments)	1	cloned	No	GBAA1751	47527043	asnO-2	asparagine synthetase, glutamine-hydroly...	607	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1CT9	25.9%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP01984 (show subtarget assignments)	1	expressed	No	CBU_0831	29541425	asnB-1	asparagine synthetase B, glutamine-hydro...	632	Conserved; Drug target functions	Phase 3: June 2008	1CT9	18.8%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP04501 (show subtarget assignments)	1	cloned	No	VC0991	9655452		asparagine synthetase B, glutamine-hydro...	554	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CT9	75.3%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP90796 (show subtarget assignments)	8	purified	No	YPO2218	16122447	topA	DNA topoisomerase I [Yersinia pestis CO9...	871	Predicted Essential	Community Requests	1CY0	57.4%	Yersinia pestis

IDP90524 (show subtarget assignments)	8	purified	No	VC1730	15641734		DNA topoisomerase I [Vibrio cholerae O1 ...	876	Predicted Essential	Community Requests	1CY0	48.3%	Vibrio cholerae

IDP05361 (show subtarget assignments)	1	cloned	No	BA_1162	30254880		alpha-amylase family protein [Bacillus a...	433	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1CYG	26.7%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP90297 (show subtarget assignments)	8	purified	No	TGME49_065450	211966338		hexokinase [Toxoplasma gondii ME49]	468	Hexokinase (TgHK) is one of 5 major glycolytic enzymes characterized in Toxoplas...	Community Requests	1CZA	34.7%	Toxoplasma gondii

IDP04411 (show subtarget assignments)	1	soluble	No	YPO3589	218930599	pyrI	aspartate carbamoyltransferase regulator...	154	conserved gene; putative drug target function;	Phase 4: April 2009	1D09	77.3%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04175 (show subtarget assignments)	1	purified	No	VC2511	9657094		aspartate carbamoyltransferase, regulato...	155	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1D09	63.2%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP05747 (show subtarget assignments)	1	cloned	No	CD3439	126701062	cobT	nicotinate-nucleotide--dimethylbenzimida...	348	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1D0S	43.4%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05754 (show subtarget assignments)	1	cloned	No	lmo0627	16802669	-	pepdidoglycan bound protein [Listeria mo...	1582	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1D2P	8.4%	Listeria monocytogenes	Energy metabolism: Electron transport

IDP05425 (show subtarget assignments)	1	soluble	No	lmo0355	16802400	-	fumarate reductase flavoprotein subunit ...	506	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1D4C	40.9%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP91747 (show subtarget assignments)	8	selected	No	Q8WLQ7_HUMAN	0			79	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1D5M	94.9%	Homo sapiens

IDP05706 (show subtarget assignments)	1	purified	No	lmo2756	16804793	topB	DNA topoisomerase III [Listeria monocyto...	717	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1D6M	28.6%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP04081 (show subtarget assignments)	1	purified	No	BAS0361	49183389		DNA topoisomerase III [Bacillus anthraci...	729	Proposed to be essential proteins	Phase 4: April 2009	1D6M	27.7%	Bacillus anthracis

IDP00411 (show subtarget assignments)	1	purified	No	YPO0161	16120504	nirB	nitrite reductase	848	Drug Target Function	Phase 2: March 2008	1D7Y	13.6%	Yersinia pestis	Energy metabolism	Electron transport

IDP02681 (show subtarget assignments)	1	soluble	No	STM3682	16766967	selB	selenocysteinyl-tRNA-specific translatio...	616	Conserved; Drug target functions	Phase 3: June 2008	1D8T	19%	Salmonella enterica	Protein synthesis	Translation factors

IDP01035 (show subtarget assignments)	0	work_stopped	No	STM4146	16767400	tuf	elongation factor Tu	394	Conserved Gene / Pathway	Phase 2: March 2008	1D8T	99.5%	Salmonella enterica	Protein synthesis	Translation factors

IDP01057 (show subtarget assignments)	0	work_stopped	No	STM3445	16766734	tuf	elongation factor Tu	394	Conserved Gene / Pathway	Phase 2: March 2008	1D8T	99.5%	Salmonella enterica	Protein synthesis	Translation factors

IDP92058 (show subtarget assignments)	8	selected	No	ACN59873	224590780	prex	plastid replication-repair enzyme [Toxop...	2579	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1D8Y	7.2%	Toxoplasma gondii

IDP91781 (show subtarget assignments)	8	purified	No	AAV80411	56155277	tetO	TetO [Enterococcus faecalis]	639	drug resistance / Tetracycline resistance	Community Requests	1DAR	27.9%	Enterococcus faecalis

IDP91780 (show subtarget assignments)	8	cloned	No	CAA27977	48190		unnamed protein product [Enterococcus fa...	639	drug resistance / Tetracycline resistance	Community Requests	1DAR	28.4%	Enterococcus faecalis

IDP91789 (show subtarget assignments)	8	purified	No	TETS_LISMO	6094462		RecName: Full=Tetracycline resistance pr...	641	drug resistance / Tetracycline resistance	Community Requests	1DAR	27.6%	Listeria monocytogenes

IDP01481 (show subtarget assignments)	1	expressed	No	VCA0130	15600901		D-ribose transporter subunit RbsB	294	Conserved Gene / Pathway	Phase 2: March 2008	1DBP	65.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04421 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4022	47529315	pyrF	orotidine 5'-phosphate decarboxylase [Ba...	238	putative drug target function;	Phase 4: April 2009	1DBT	61.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04079 (show subtarget assignments)	1	purified	No	BAS0100	49183134		50S ribosomal protein L7/L12 [Bacillus a...	119	Proposed to be essential proteins	Phase 4: April 2009	1DD3	63.3%	Bacillus anthracis

IDP92008 (show subtarget assignments)	8	selected	No	ACU65240	256260269		mutant IMP-1 metallo-beta-lactamase [syn...	246	drug resistance / 256260269: We have characterized this metallo-beta-lactamase variant biochemical...	Community Requests	1DD6	92.3%	synthetic construct

IDP92009 (show subtarget assignments)	8	selected	No	ACU65237	256260263		mutant IMP-6 metallo-beta-lactamase [syn...	246	drug resistance / 256260263: We have biochemically characterized this metallo-beta-lactamase varia...	Community Requests	1DD6	91.9%	synthetic construct

IDP91229 (show subtarget assignments)	8	soluble	No	NT04EC2950	26109117	fabB	3-oxoacyl-[acyl-carrier-protein] synthas...	363	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1DD8	100%	Escherichia coli	Fatty acid and phospholipid metabolism: Biosynthesis

IDP90940 (show subtarget assignments)	8	cloned	No	NMPDR 243277.1.peg.3912				278	Predicted Essential	Community Requests	1DD8	61.9%	Vibrio cholerae

IDP90554 (show subtarget assignments)	8	selected	No	NMPDR 243277.1.peg.3911				163	Predicted Essential	Community Requests	1DD8	81%	Vibrio cholerae

IDP90503 (show subtarget assignments)	8	purified	No	NP_230169	15642769		DNA primase [Vibrio cholerae O1 biovar e...	587	Predicted Essential	Community Requests	1DD9	30.8%	Vibrio cholerae

IDP90594 (show subtarget assignments)	8	in_crystallization_trials	No	YPO0644	16120969	dnaG	DNA primase [Yersinia pestis CO92]	582	Predicted Essential	Community Requests	1DD9	45.7%	Yersinia pestis

IDP90681 (show subtarget assignments)	8	purified	No	STM3210	16766510	dnaG	DNA primase [Salmonella typhimurium LT2]...	581	Predicted Essential	Community Requests	1DD9	46.1%	Salmonella enterica

IDP02581 (show subtarget assignments)	1	purified	No	YPO3372	16123521	cysJ	sulfite reductase subunit alpha [Yersini...	606	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1DDG	47.9%	Yersinia pestis	Central intermediary metabolism	Sulfur metabolism

IDP04137 (show subtarget assignments)	1	soluble	No	BAS0134	49183168		50S ribosomal protein L36 [Bacillus anth...	37	Proposed to be essential proteins	Phase 4: April 2009	1DFE	81.1%	Bacillus anthracis

IDP92552 (show subtarget assignments)	8	selected	No	NP_071445	11545912	NOD2	nucleotide-binding oligomerization domai...	1040	innate immunity / JUSTIFICATION:NOD2 is a cytoplasmic protein containing 1040 residus and three fu...	Community Requests	1DFJ	9%	Homo sapiens

IDP01846 (show subtarget assignments)	1	soluble	No	CBU_1419	29541979		serine hydroxymethyltransferase [Coxiell...	419	Conserved; Drug target functions	Phase 3: June 2008	1DFO	68.5%	Coxiella burnetii	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02260 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA0072	47777774	folB	dihydroneopterin aldolase [Bacillus anth...	120	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1DHN	43.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04628 (show subtarget assignments)	1	soluble	No	BAS5322	49188306		50S ribosomal protein L9 [Bacillus anthr...	148	Proposed to be essential proteins	Phase 4: April 2009	1DIV	75%	Bacillus anthracis

IDP01672 (show subtarget assignments)	1	soluble	No	GBAA5133	47530438		hypothetical protein GBAA5133 [Bacillus ...	396	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1DJU	48.2%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01403 (show subtarget assignments)	1	in_crystallization_trials	No	VC0854	15640870		heat shock protein GrpE	200	Conserved Gene / Pathway	Phase 2: March 2008	1DKG	39.5%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP00491 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1107	16121407		heat shock protein GrpE	192	Conserved Gene / Pathway	Phase 2: March 2008	1DKG	59.4%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP02284 (show subtarget assignments)	1	soluble	No	CBU_1293	29541861	grpE	heat shock protein GrpE [Coxiella burnet...	204	Conserved; Drug target functions	Phase 3: June 2008	1DKG	35.3%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP01229 (show subtarget assignments)	1	soluble	No	BA_4540	52782922		Protein grpE (HSP-70 cofactor)	188	Conserved Gene / Pathway	Phase 2: March 2008	1DKG	34.9%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP02360 (show subtarget assignments)	1	soluble	No	FTT1270c	56708330	grpE	heat shock protein GrpE [Francisella tul...	195	Conserved; Drug target functions	Phase 3: June 2008	1DKG	36.9%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP04206 (show subtarget assignments)	1	cloned	No	CPF_2812	110799133	prsA	ribose-phosphate pyrophosphokinase [Clos...	319	conserved gene; putative drug target function;	Phase 4: April 2009	1DKR	63%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01180 (show subtarget assignments)	1	cloned	No	BA_0049	46396353		Ribose-phosphate pyrophosphokinase (RPPK...	317	Conserved Gene / Pathway	Phase 2: March 2008	1DKR	85.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90509 (show subtarget assignments)	8	purified	No	Cj0347	15791715	trpF	N-(5'phosphoribosyl)anthranilate isomera...	199	Predicted Essential	Community Requests	1DL3	31.4%	Campylobacter jejuni

IDP91404 (show subtarget assignments)	8	soluble	No	VV1_0879	27364327		ribosome-associated heat shock protein i...	128	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1DM9	64.8%	Vibrio vulnificus

IDP01031 (show subtarget assignments)	0	work_stopped	No	STM3497	16766785	yrfH	ribosome-associated heat shock protein H...	133	Conserved Gene / Pathway	Phase 2: March 2008	1DM9	95.5%	Salmonella enterica	Protein synthesis	Other

IDP04583 (show subtarget assignments)	1	cloned	No	BAS0111	49183145		50S ribosomal protein L4 [Bacillus anthr...	207	Proposed to be essential proteins	Phase 4: April 2009	1DMG	47.1%	Bacillus anthracis

IDP02018 (show subtarget assignments)	1	expressed	No	STM2530	16765850		putative anaerobic dimethylsulfoxide red...	801	Conserved; Drug target functions	Phase 3: June 2008	1DMR	30.1%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01896 (show subtarget assignments)	1	soluble	No	STM0611	16763988		putative oxidoreductase protein [Salmone...	759	Conserved; Drug target functions	Phase 3: June 2008	1DMR	29.2%	Salmonella enterica	Energy metabolism	ATP-proton motive force interconversion

IDP01620 (show subtarget assignments)	1	cloned	No	FTT0687c	56707807	hslU	ATP-dependent protease ATP-binding subun...	455	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1DO0	64.6%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01995 (show subtarget assignments)	1	soluble	No	CBU_2012	29542567	hslU	heat shock protein HslVU, ATPase subunit...	447	Conserved; Drug target functions	Phase 3: June 2008	1DO0	67.3%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP91957 (show subtarget assignments)	8	selected	No	SpneCM_010100004917	298254940		oligopeptide-binding protein AliB [Strep...	653	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1DPE	22.2%	Streptococcus pneumoniae

IDP01363 (show subtarget assignments)	1	soluble	No	VC0171	15640201		peptide ABC transporter, periplasmic pep...	542	Conserved Gene / Pathway	Phase 2: March 2008	1DPE	27.1%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01961 (show subtarget assignments)	1	soluble	No	STM1692	16765035	sapA	peptide transport protein [Salmonella ty...	549	Conserved; Drug target functions	Phase 3: June 2008	1DPP	34.1%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00428 (show subtarget assignments)	1	expressed	No	YPO2355	16122579	sapA	peptide transport periplasmic protein pr...	548	Conserved Gene / Pathway	Phase 2: March 2008	1DPP	36.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00536 (show subtarget assignments)	1	purified	No	YPO4003	16124128	dppA	periplasmic dipeptide transport protein ...	535	Virulence Associated Factor	Phase 2: March 2008	1DPP	81.5%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01140
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4546

33301122

Germination protease precursor (Spore pr...

368

Drug Target Function

Phase 2: March 2008

1C8B

70.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90627
(show subtarget assignments)

8

selected

No

VC1239

15641252

cobU

adenosylcobinamide kinase/adenosylcobina...

179

Predicted Essential

Community Requests

1C9K

41.3%

Vibrio cholerae

IDP01102
(show subtarget assignments)

1

soluble

No

BA_5424

49040749

Cold shock-like protein cspC

65

Essential Gene

Phase 2: March 2008

1C9O

74.2%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP01344
(show subtarget assignments)

1

crystallized

No

VCA1025

15601778

nagB

glucosamine-6-phosphate deaminase

266

Drug Target Function

Phase 2: March 2008

1CD5

79.3%

Vibrio cholerae

Energy metabolism

Sugars

IDP04113
(show subtarget assignments)

1

selected

No

YPO2627

115348319

glmD

putative glucosamine-6-phosphate isomera...

266

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CD5

85.7%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP02331
(show subtarget assignments)

1

selected

No

GBAA2661

47527952

adP-1

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

30.7%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02566
(show subtarget assignments)

1

purified

No

GBAA3033

50196939

adP-2

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

31.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01967
(show subtarget assignments)

1

soluble

No

STM1789

16765130

hydrogenase 1 maturation protease [Salmo...

198

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1CFZ

30.8%

Salmonella enterica

Energy metabolism

Aerobic

IDP01909
(show subtarget assignments)

1

soluble

No

STM1536

16764881

putative hydrogenase maturation protease...

202

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1CFZ

30.7%

Salmonella enterica

Energy metabolism

Aerobic

IDP90502
(show subtarget assignments)

8

purified

No

Q9KPA4

22653875

RecName: Full=L-aspartate oxidase; Short...

535

Predicted Essential

Community Requests

1CHU

75.3%

Vibrio cholerae

IDP02607
(show subtarget assignments)

1

expressed

No

CBU_0101

29540723

nadB

L-aspartate oxidase [Coxiella burnetii R...

536

Conserved; Drug target functions

Phase 3: June 2008

1CHU

52.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP90902
(show subtarget assignments)

8

in_crystallization_trials

No

STM2641

16765961

nadB

L-aspartate oxidase [Salmonella typhimur...

540

Predicted Essential

Community Requests

1CHU

89.6%

Salmonella enterica

IDP05741
(show subtarget assignments)

1

purified

No

CD2371

126699986

nadB

L-aspartate oxidase [Clostridium diffici...

433

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1CHU

37%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP02753
(show subtarget assignments)

1

expressed

No

GBAA4662

47529960

nadB

L-aspartate oxidase [Bacillus anthracis ...

509

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1CHU

37.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP02462
(show subtarget assignments)

1

expressed

No

FTT1467c

56708507

nadB

L-aspartate oxidase [Francisella tularen...

495

Conserved; Drug target functions

Phase 3: June 2008

1CHU

38.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP90914
(show subtarget assignments)

8

purified

No

YPO2710

16122914

nadB

L-aspartate oxidase [Yersinia pestis CO9...

545

Predicted Essential

Community Requests

1CHU

82%

Yersinia pestis

IDP92057
(show subtarget assignments)

8

selected

No

TGME49_061030

237831917

mitochondrial NADPH:adrenodoxin oxidored...

656

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1CJC

25%

Toxoplasma gondii

IDP04640
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0559c

56707689

cmk

cytidylate kinase [Francisella tularensi...

221

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CKE

47.1%

Francisella tularensis

IDP90888
(show subtarget assignments)

8

in_crystallization_trials

No

Q9KQT2

22001682

RecName: Full=Cytidylate kinase; Short=C...

225

Predicted Essential

Community Requests

1CKE

70.2%

Vibrio cholerae

IDP02383
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0489c

56707631

trxB

thioredoxin reductase [Francisella tular...

316

Drug Target

Phase 3: June 2008

1CL0

66.8%

Francisella tularensis

Energy metabolism

Electron transport

IDP90913
(show subtarget assignments)

8

soluble

No

VC1182

15641195

thioredoxin reductase [Vibrio cholerae O...

318

Predicted Essential

Community Requests

1CL0

81.4%

Vibrio cholerae

IDP02353
(show subtarget assignments)

1

soluble

No

YPO1374

16121654

trxB

thioredoxin reductase [Yersinia pestis C...

320

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1CL0

85%

Yersinia pestis

Energy metabolism

Electron transport

IDP02250
(show subtarget assignments)

1

soluble

No

YPO0278

16120617

metC

cystathionine beta-lyase [Yersinia pesti...

393

Involved in virulence; Drug target functions

Phase 3: June 2008

1CL2

42.2%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP04124
(show subtarget assignments)

1

crystallized

No

YPO2828

218929893

purI

phosphoribosylaminoimidazole synthetase ...

347

conserved gene; putative drug target function;

Phase 4: April 2009

1CLI

81.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01989
(show subtarget assignments)

1

purified

No

STM2646

16765966

yfiD

autonomous glycyl radical cofactor GrcA ...

127

Conserved; Drug target functions

Phase 3: June 2008

1CM5

38.6%

Salmonella enterica

Energy metabolism

Anaerobic

IDP90991
(show subtarget assignments)

8

cloned

No

y1282

22125182

formate acetyltransferase [Yersinia pest...

150

other biological interest / stress-response protein replacind PflA in PflA/PflB complex

Community Requests

1CM5

40%

Yersinia pestis

IDP04444
(show subtarget assignments)

1

soluble

No

YPO0532

115346340

leuB

3-isopropylmalate dehydrogenase [Yersini...

365

conserved gene; putative drug target function;

Phase 4: April 2009

1CM7

85.5%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP02136
(show subtarget assignments)

1

purified

No

YPO0114

16120460

metJ

transcriptional repressor protein MetJ [...

105

Involved in virulence; Drug target functions

Phase 3: June 2008

1CMA

88.6%

Yersinia pestis

Regulatory functions

DNA interactions

IDP91431
(show subtarget assignments)

8

cloned

No

VV1_0489

27363953

Trp operon repressor [Vibrio vulnificus ...

102

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1CO0

46.1%

Vibrio vulnificus

IDP02405
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1803c

56708789

trpR

trp operon repressor [Francisella tulare...

95

Drug Target

Phase 3: June 2008

1CO0

30.5%

Francisella tularensis

Amino acid biosynthesisRegulatory functions

Aromatic amino acid familyDNA interactions

IDP90612
(show subtarget assignments)

8

soluble

No

NMPDR 243277.1.peg.3916

281

Predicted Essential

Community Requests

1COZ

17.1%

Vibrio cholerae

IDP90676
(show subtarget assignments)

8

expressed

No

Cj0533

15791894

sucC

succinyl-CoA synthase, beta subunit [Cam...

387

Predicted Essential

Community Requests

1CQI

45.5%

Campylobacter jejuni

IDP02187
(show subtarget assignments)

1

purified

No

FTT0504c

56707643

sucC

succinyl-CoA synthetase subunit beta [Fr...

387

Conserved; Drug target functions

Phase 3: June 2008

1CQI

62.8%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02490
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3974

47529264

sucC

succinyl-CoA synthetase subunit beta [Ba...

386

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1CQI

54.7%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP02692
(show subtarget assignments)

1

expressed

No

FTT0503c

56707642

sucD

succinyl-CoA synthetase, alpha subunit [...

290

Conserved; Drug target functions

Phase 3: June 2008

1CQI

75.5%

Francisella tularensis

Energy metabolism

TCA cycle

IDP00644
(show subtarget assignments)

1

expressed

No

SACOL0220

57286684

flavohemoprotein, putative

381

Conserved Gene / Pathway

Phase 2: March 2008

1CQX

36.9%

Staphylococcus aureus

Unknown function

General

IDP90910
(show subtarget assignments)

8

soluble

No

VC2390

15642387

carbamoyl phosphate synthase small subun...

379

Predicted Essential

Community Requests

1CS0

82.3%

Vibrio cholerae

IDP00610
(show subtarget assignments)

1

cloned

No

SACOL1437

57286088

cold shock protein, CSD family

66

Conserved Gene / Pathway

Phase 2: March 2008

1CSP

75.8%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP01111
(show subtarget assignments)

1

cloned

No

BA_1135

49035527

Major cold shock protein cspA

67

Conserved Gene / Pathway

Phase 2: March 2008

1CSP

73.1%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP02245
(show subtarget assignments)

1

cloned

No

GBAA1751

47527043

asnO-2

asparagine synthetase, glutamine-hydroly...

607

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1CT9

25.9%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP01984
(show subtarget assignments)

1

expressed

No

CBU_0831

29541425

asnB-1

asparagine synthetase B, glutamine-hydro...

632

Conserved; Drug target functions

Phase 3: June 2008

1CT9

18.8%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP04501
(show subtarget assignments)

1

cloned

No

VC0991

9655452

asparagine synthetase B, glutamine-hydro...

554

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CT9

75.3%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP90796
(show subtarget assignments)

8

purified

No

YPO2218

16122447

topA

DNA topoisomerase I [Yersinia pestis CO9...

871

Predicted Essential

Community Requests

1CY0

57.4%

Yersinia pestis

IDP90524
(show subtarget assignments)

8

purified

No

VC1730

15641734

DNA topoisomerase I [Vibrio cholerae O1 ...

876

Predicted Essential

Community Requests

1CY0

48.3%

Vibrio cholerae

IDP05361
(show subtarget assignments)

1

cloned

No

BA_1162

30254880

alpha-amylase family protein [Bacillus a...

433

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1CYG

26.7%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP90297
(show subtarget assignments)

8

purified

No

TGME49_065450

211966338

hexokinase [Toxoplasma gondii ME49]

468

Hexokinase (TgHK) is one of 5 major glycolytic enzymes characterized in Toxoplas...

Community Requests

1CZA

34.7%

Toxoplasma gondii

IDP04411
(show subtarget assignments)

1

soluble

No

YPO3589

218930599

pyrI

aspartate carbamoyltransferase regulator...

154

conserved gene; putative drug target function;

Phase 4: April 2009

1D09

77.3%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04175
(show subtarget assignments)

1

purified

No

VC2511

9657094

aspartate carbamoyltransferase, regulato...

155

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1D09

63.2%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP05747
(show subtarget assignments)

1

cloned

No

CD3439

126701062

cobT

nicotinate-nucleotide--dimethylbenzimida...

348

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1D0S

43.4%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05754
(show subtarget assignments)

1

cloned

No

lmo0627

16802669

-

pepdidoglycan bound protein [Listeria mo...

1582

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1D2P

8.4%

Listeria monocytogenes

Energy metabolism: Electron transport

IDP05425
(show subtarget assignments)

1

soluble

No

lmo0355

16802400

-

fumarate reductase flavoprotein subunit ...

506

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1D4C

40.9%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP91747
(show subtarget assignments)

8

selected

No

Q8WLQ7_HUMAN

0

79

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1D5M

94.9%

Homo sapiens

IDP05706
(show subtarget assignments)

1

purified

No

lmo2756

16804793

topB

DNA topoisomerase III [Listeria monocyto...

717

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1D6M

28.6%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP04081
(show subtarget assignments)

1

purified

No

BAS0361

49183389

DNA topoisomerase III [Bacillus anthraci...

729

Proposed to be essential proteins

Phase 4: April 2009

1D6M

27.7%

Bacillus anthracis

IDP00411
(show subtarget assignments)

1

purified

No

YPO0161

16120504

nirB

nitrite reductase

848

Drug Target Function

Phase 2: March 2008

1D7Y

13.6%

Yersinia pestis

Energy metabolism

Electron transport

IDP02681
(show subtarget assignments)

1

soluble

No

STM3682

16766967

selB

selenocysteinyl-tRNA-specific translatio...

616

Conserved; Drug target functions

Phase 3: June 2008

1D8T

19%

Salmonella enterica

Protein synthesis

Translation factors

IDP01035
(show subtarget assignments)

0

work_stopped

No

STM4146

16767400

tuf

elongation factor Tu

394

Conserved Gene / Pathway

Phase 2: March 2008

1D8T

99.5%

Salmonella enterica

Protein synthesis

Translation factors

IDP01057
(show subtarget assignments)

0

work_stopped

No

STM3445

16766734

tuf

elongation factor Tu

394

Conserved Gene / Pathway

Phase 2: March 2008

1D8T

99.5%

Salmonella enterica

Protein synthesis

Translation factors

IDP92058
(show subtarget assignments)

8

selected

No

ACN59873

224590780

prex

plastid replication-repair enzyme [Toxop...

2579

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1D8Y

7.2%

Toxoplasma gondii

IDP91781
(show subtarget assignments)

8

purified

No

AAV80411

56155277

tetO

TetO [Enterococcus faecalis]

639

drug resistance / Tetracycline resistance

Community Requests

1DAR

27.9%

Enterococcus faecalis

IDP91780
(show subtarget assignments)

8

cloned

No

CAA27977

48190

unnamed protein product [Enterococcus fa...

639

drug resistance / Tetracycline resistance

Community Requests

1DAR

28.4%

Enterococcus faecalis

IDP91789
(show subtarget assignments)

8

purified

No

TETS_LISMO

6094462

RecName: Full=Tetracycline resistance pr...

641

drug resistance / Tetracycline resistance

Community Requests

1DAR

27.6%

Listeria monocytogenes

IDP01481
(show subtarget assignments)

1

expressed

No

VCA0130

15600901

D-ribose transporter subunit RbsB

294

Conserved Gene / Pathway

Phase 2: March 2008

1DBP

65.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04421
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4022

47529315

pyrF

orotidine 5'-phosphate decarboxylase [Ba...

238

putative drug target function;

Phase 4: April 2009

1DBT

61.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04079
(show subtarget assignments)

1

purified

No

BAS0100

49183134

50S ribosomal protein L7/L12 [Bacillus a...

119

Proposed to be essential proteins

Phase 4: April 2009

1DD3

63.3%

Bacillus anthracis

IDP92008
(show subtarget assignments)

8

selected

No

ACU65240

256260269

mutant IMP-1 metallo-beta-lactamase [syn...

246

drug resistance / 256260269: We have characterized this metallo-beta-lactamase variant biochemical...

Community Requests

1DD6

92.3%

synthetic construct

IDP92009
(show subtarget assignments)

8

selected

No

ACU65237

256260263

mutant IMP-6 metallo-beta-lactamase [syn...

246

drug resistance / 256260263: We have biochemically characterized this metallo-beta-lactamase varia...

Community Requests

1DD6

91.9%

synthetic construct

IDP91229
(show subtarget assignments)

8

soluble

No

NT04EC2950

26109117

fabB

3-oxoacyl-[acyl-carrier-protein] synthas...

363

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1DD8

100%

Escherichia coli

Fatty acid and phospholipid metabolism: Biosynthesis

IDP90940
(show subtarget assignments)

8

cloned

No

NMPDR 243277.1.peg.3912

278

Predicted Essential

Community Requests

1DD8

61.9%

Vibrio cholerae

IDP90554
(show subtarget assignments)

8

selected

No

NMPDR 243277.1.peg.3911

163

Predicted Essential

Community Requests

1DD8

81%

Vibrio cholerae

IDP90503
(show subtarget assignments)

8

purified

No

NP_230169

15642769

DNA primase [Vibrio cholerae O1 biovar e...

587

Predicted Essential

Community Requests

1DD9

30.8%

Vibrio cholerae

IDP90594
(show subtarget assignments)

8

in_crystallization_trials

No

YPO0644

16120969

dnaG

DNA primase [Yersinia pestis CO92]

582

Predicted Essential

Community Requests

1DD9

45.7%

Yersinia pestis

IDP90681
(show subtarget assignments)

8

purified

No

STM3210

16766510

dnaG

DNA primase [Salmonella typhimurium LT2]...

581

Predicted Essential

Community Requests

1DD9

46.1%

Salmonella enterica

IDP02581
(show subtarget assignments)

1

purified

No

YPO3372

16123521

cysJ

sulfite reductase subunit alpha [Yersini...

606

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1DDG

47.9%

Yersinia pestis

Central intermediary metabolism

Sulfur metabolism

IDP04137
(show subtarget assignments)

1

soluble

No

BAS0134

49183168

50S ribosomal protein L36 [Bacillus anth...

37

Proposed to be essential proteins

Phase 4: April 2009

1DFE

81.1%

Bacillus anthracis

IDP92552
(show subtarget assignments)

8

selected

No

NP_071445

11545912

NOD2

nucleotide-binding oligomerization domai...

1040

innate immunity / JUSTIFICATION:NOD2 is a cytoplasmic protein containing 1040 residus and three fu...

Community Requests

1DFJ

9%

Homo sapiens

IDP01846
(show subtarget assignments)

1

soluble

No

CBU_1419

29541979

serine hydroxymethyltransferase [Coxiell...

419

Conserved; Drug target functions

Phase 3: June 2008

1DFO

68.5%

Coxiella burnetii

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02260
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA0072

47777774

folB

dihydroneopterin aldolase [Bacillus anth...

120

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1DHN

43.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04628
(show subtarget assignments)

1

soluble

No

BAS5322

49188306

50S ribosomal protein L9 [Bacillus anthr...

148

Proposed to be essential proteins

Phase 4: April 2009

1DIV

75%

Bacillus anthracis

IDP01672
(show subtarget assignments)

1

soluble

No

GBAA5133

47530438

hypothetical protein GBAA5133 [Bacillus ...

396

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1DJU

48.2%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01403
(show subtarget assignments)

1

in_crystallization_trials

No

VC0854

15640870

heat shock protein GrpE

200

Conserved Gene / Pathway

Phase 2: March 2008

1DKG

39.5%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP00491
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1107

16121407

heat shock protein GrpE

192

Conserved Gene / Pathway

Phase 2: March 2008

1DKG

59.4%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP02284
(show subtarget assignments)

1

soluble

No

CBU_1293

29541861

grpE

heat shock protein GrpE [Coxiella burnet...

204

Conserved; Drug target functions

Phase 3: June 2008

1DKG

35.3%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP01229
(show subtarget assignments)

1

soluble

No

BA_4540

52782922

Protein grpE (HSP-70 cofactor)

188

Conserved Gene / Pathway

Phase 2: March 2008

1DKG

34.9%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP02360
(show subtarget assignments)

1

soluble

No

FTT1270c

56708330

grpE

heat shock protein GrpE [Francisella tul...

195

Conserved; Drug target functions

Phase 3: June 2008

1DKG

36.9%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP04206
(show subtarget assignments)

1

cloned

No

CPF_2812

110799133

prsA

ribose-phosphate pyrophosphokinase [Clos...

319

conserved gene; putative drug target function;

Phase 4: April 2009

1DKR

63%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01180
(show subtarget assignments)

1

cloned

No

BA_0049

46396353

Ribose-phosphate pyrophosphokinase (RPPK...

317

Conserved Gene / Pathway

Phase 2: March 2008

1DKR

85.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90509
(show subtarget assignments)

8

purified

No

Cj0347

15791715

trpF

N-(5'phosphoribosyl)anthranilate isomera...

199

Predicted Essential

Community Requests

1DL3

31.4%

Campylobacter jejuni

IDP91404
(show subtarget assignments)

8

soluble

No

VV1_0879

27364327

ribosome-associated heat shock protein i...

128

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1DM9

64.8%

Vibrio vulnificus

IDP01031
(show subtarget assignments)

0

work_stopped

No

STM3497

16766785

yrfH

ribosome-associated heat shock protein H...

133

Conserved Gene / Pathway

Phase 2: March 2008

1DM9

95.5%

Salmonella enterica

Protein synthesis

Other

IDP04583
(show subtarget assignments)

1

cloned

No

BAS0111

49183145

50S ribosomal protein L4 [Bacillus anthr...

207

Proposed to be essential proteins

Phase 4: April 2009

1DMG

47.1%

Bacillus anthracis

IDP02018
(show subtarget assignments)

1

expressed

No

STM2530

16765850

putative anaerobic dimethylsulfoxide red...

801

Conserved; Drug target functions

Phase 3: June 2008

1DMR

30.1%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01896
(show subtarget assignments)

1

soluble

No

STM0611

16763988

putative oxidoreductase protein [Salmone...

759

Conserved; Drug target functions

Phase 3: June 2008

1DMR

29.2%

Salmonella enterica

Energy metabolism

ATP-proton motive force interconversion

IDP01620
(show subtarget assignments)

1

cloned

No

FTT0687c

56707807

hslU

ATP-dependent protease ATP-binding subun...

455

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1DO0

64.6%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01995
(show subtarget assignments)

1

soluble

No

CBU_2012

29542567

hslU

heat shock protein HslVU, ATPase subunit...

447

Conserved; Drug target functions

Phase 3: June 2008

1DO0

67.3%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP91957
(show subtarget assignments)

8

selected

No

SpneCM_010100004917

298254940

oligopeptide-binding protein AliB [Strep...

653

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1DPE

22.2%

Streptococcus pneumoniae

IDP01363
(show subtarget assignments)

1

soluble

No

VC0171

15640201

peptide ABC transporter, periplasmic pep...

542

Conserved Gene / Pathway

Phase 2: March 2008

1DPE

27.1%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01961
(show subtarget assignments)

1

soluble

No

STM1692

16765035

sapA

peptide transport protein [Salmonella ty...

549

Conserved; Drug target functions

Phase 3: June 2008

1DPP

34.1%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00428
(show subtarget assignments)

1

expressed

No

YPO2355

16122579

sapA

peptide transport periplasmic protein pr...

548

Conserved Gene / Pathway

Phase 2: March 2008

1DPP

36.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00536
(show subtarget assignments)

1

purified

No

YPO4003

16124128

dppA

periplasmic dipeptide transport protein ...

535

Virulence Associated Factor

Phase 2: March 2008

1DPP

81.5%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines