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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 3 of 60, showing 100 records out of 5973 total, starting on record 201
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP90425
(
show subtarget assignments
)
8
expressed
No
CT_547
3328986
hypothetical protein [Chlamydia trachoma...
318
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3QKY
11.9%
Chlamydia trachomatis
IDP04265
(
show subtarget assignments
)
1
purified
No
CPF_2105
110800754
putative cell division protein DivIVA [C...
208
conserved gene; putative drug target function;
Phase 4: April 2009
2WUJ
12%
Clostridium perfringens
Cellular processes
Cell division
IDP00997
(
show subtarget assignments
)
1
soluble
No
STM2314
16765641
putative chemotaxis signal transduction ...
333
Conserved Gene / Pathway
Phase 2: March 2008
1K68
12%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP91946
(
show subtarget assignments
)
8
selected
No
SpneCM_010100004617
298254882
integral membrane protein [Streptococcus...
317
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3KMI
12%
Streptococcus pneumoniae
IDP04182
(
show subtarget assignments
)
1
cloned
No
VCA0238
15601006
sensor histidine kinase [Vibrio cholerae...
549
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
12%
Vibrio cholerae
Regulatory functions
Other
IDP04185
(
show subtarget assignments
)
1
expressed
No
VCA0683
15601440
sensor protein UhpB [Vibrio cholerae O1 ...
527
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3GIG
12%
Vibrio cholerae
Regulatory functions
Other
IDP91715
(
show subtarget assignments
)
8
selected
No
NP_008917
52632377
MAGED1
melanoma-associated antigen D1 isoform b...
778
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3NW0
12.1%
Homo sapiens
IDP91750
(
show subtarget assignments
)
8
selected
No
SPG2_STRSG
0
593
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2KN4
12.1%
Streptococcus sp.
IDP91765
(
show subtarget assignments
)
8
purified
No
YPTB1885
51596217
ThiF family protein [Yersinia pseudotube...
577
other biological interest; innate immunity /
Yersinia pseudotuberculosis MccB-like (MccB homologs) - E.coli MccB catalyses ad...
Community Requests
3H5A
12.1%
Yersinia pseudotuberculosis
IDP90953
(
show subtarget assignments
)
8
expressed
No
VF0985
75354249
Sensory box/GGDEF family protein
827
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3HVB
12.1%
Vibrio fischeri
IDP05358
(
show subtarget assignments
)
1
cloned
No
BA_0685
30254284
conserved hypothetical protein [Bacillus...
420
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1I84
12.1%
Bacillus anthracis
Hypothetical proteins: Conserved
IDP92010
(
show subtarget assignments
)
8
selected
No
TGME49_069660
237832699
TFIIH basal transcription factor complex...
997
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2FWR
12.2%
Toxoplasma gondii
IDP91578
(
show subtarget assignments
)
8
cloned
No
BAB37984
13364036
ECs4561
translocated intimin receptor Tir [Esche...
558
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2ZQK
12.2%
Escherichia coli
IDP02155
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO0239
16120577
trkA
potassium transporter peripheral membran...
458
Conserved; CD; Drug target functions
Phase 3: June 2008
1LSS
12.2%
Yersinia pestis
Transport and binding proteins
Cations and iron carrying compounds
IDP90201
(
show subtarget assignments
)
8
cloned
No
AAM13653.1
20153192
CPXV215 CDS
CPXV215 Protein
557
kelch-like protein
Community Requests
2VPJ
12.2%
Cowpox virus
conserved hypothetical proteins
0
IDP90961
(
show subtarget assignments
)
8
purified
No
VP0117
81728759
GGDEF family protein
848
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
12.3%
Vibrio parahaemolyticus
IDP00466
(
show subtarget assignments
)
1
cloned
No
YPO1536
16121809
putative iron-siderophore transport syst...
359
Conserved Gene / Pathway
Phase 2: March 2008
3MWF
12.3%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP90003
(
show subtarget assignments
)
8
crystallized
No
FTT1103
56708183
conserved hypothetical lipoprotein
365
(Community Request)
Community Requests
3GYK
12.3%
Francisella tularensis
IDP91010
(
show subtarget assignments
)
8
cloned
No
y2245
22126131
hypothetical protein y2245 [Yersinia pes...
341
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
3ETN
12.3%
Yersinia pestis
IDP90188
(
show subtarget assignments
)
8
cloned
No
AAM13496.1
20153035
CPXV050 CDS
CPXV050 protein
480
kelch-like protein
Community Requests
3II7
12.3%
Cowpox virus
conserved hypothetical proteins
0
IDP04271
(
show subtarget assignments
)
1
expressed
No
CPF_2241
110798635
sensor histidine kinase [Clostridium per...
678
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
12.4%
Clostridium perfringens
Signal transduction
Two-component systems
IDP91983
(
show subtarget assignments
)
8
selected
No
SpneCM_010100000697
298254118
beta-galactosidase [Streptococcus pneumo...
2233
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3GM8
12.4%
Streptococcus pneumoniae
IDP01862
(
show subtarget assignments
)
1
soluble
No
GBAA5510
47530828
tagH
teichoic acids export protein ATP-bindin...
549
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1F3O
12.4%
Bacillus anthracis
Transport and binding proteins
Other
IDP91664
(
show subtarget assignments
)
8
selected
No
NP_055232
15193488
BBC3
bcl-2-binding component 3 isoform 4 [Hom...
193
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2ROC
12.4%
Homo sapiens
IDP02348
(
show subtarget assignments
)
1
soluble
No
GBAA2803
47528096
S-layer protein, putative [Bacillus anth...
461
Drug target motif; Drug target functions
Phase 3: June 2008
3PYW
12.4%
Bacillus anthracis
Cell envelope
Surface structures
IDP92011
(
show subtarget assignments
)
8
selected
No
TGME49_072210
237833115
hypothetical protein TGME49_072210 [Toxo...
364
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2IFT
12.4%
Toxoplasma gondii
IDP01805
(
show subtarget assignments
)
1
soluble
No
CBU_1084
29541658
sensory box sensor histidine kinase/resp...
683
Conserved; Drug target functions
Phase 3: June 2008
2C2A
12.4%
Coxiella burnetii
Signal transduction
Two-component systems
IDP91358
(
show subtarget assignments
)
8
soluble
No
VV1_2848
27366130
Signal transduction histidine kinase [Vi...
449
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3JZ3
12.5%
Vibrio vulnificus
IDP04720
(
show subtarget assignments
)
1
expressed
No
YPO1174
115346948
hypothetical protein [Yersinia pestis CO...
309
virulence factor; putative drug target function;
Phase 4: April 2009
3ULT
12.6%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP05452
(
show subtarget assignments
)
1
cloned
No
BAS5207
49188193
-
collagen adhesion protein, C-terminal [B...
882
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3KPT
12.6%
Bacillus anthracis
Protein fate: Degradation of proteins, peptides, and glycopeptides
IDP02244
(
show subtarget assignments
)
1
cloned
No
GBAA1818
47777969
N-acetylmuramoyl-L-alanine amidase [Baci...
459
Drug target motif; Involved in sporulation; Drug target functions
Phase 3: June 2008
3PYW
12.6%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP04121
(
show subtarget assignments
)
1
cloned
No
YPO2725
115348408
conserved hypothetical protein [Yersinia...
921
virulence factor; putative drug target function;
Phase 4: April 2009
2P5Z
12.6%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP91398
(
show subtarget assignments
)
8
soluble
No
VV1_1045
27364477
trkA
potassium transporter peripheral membran...
458
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3L4B
12.7%
Vibrio vulnificus
IDP90183
(
show subtarget assignments
)
8
cloned
No
AAM13482.1
20153021
CPXV035 CDS
CPXV035 protein
512
kelch-like protein
Community Requests
2XN4
12.7%
Cowpox virus
conserved hypothetical proteins
0
IDP04351
(
show subtarget assignments
)
1
cloned
No
CPF_1213
110799898
kdpD
sensor histidine kinase KdpD [Clostridiu...
900
conserved gene; putative drug target function;
Phase 4: April 2009
2R8R
12.7%
Clostridium perfringens
Regulatory functions
Protein interactions
IDP91932
(
show subtarget assignments
)
8
selected
No
SpneCM_010100007089
298255349
pneumococcal histidine triad protein E [...
189
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2CS7
12.7%
Streptococcus pneumoniae
IDP92078
(
show subtarget assignments
)
8
selected
No
TGME49_097840
237843813
DNA primase, large subunit, putative [To...
584
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3L9Q
12.7%
Toxoplasma gondii
IDP00664
(
show subtarget assignments
)
1
cloned
No
SACOL1028
57284400
htrA
serine protease
769
Drug Target Function
Phase 2: March 2008
2ZLE
12.7%
Staphylococcus aureus
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP91311
(
show subtarget assignments
)
8
purified
No
VP1659
28898433
hypothetical protein VP1659 [Vibrio para...
607
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1R6F
12.8%
Vibrio parahaemolyticus
IDP02008
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM3595
16766881
putative phosphatase [Salmonella typhimu...
423
Conserved; Drug target functions
Phase 3: June 2008
2A96
12.8%
Salmonella enterica
Central intermediary metabolism
Other
IDP05118
(
show subtarget assignments
)
1
cloned
No
Z5902
12519310
putative helicase [Escherichia coli O157...
704
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1PJR
12.8%
Escherichia coli
Protein synthesis: Ribosomal proteins: synthesis and modification
IDP90984
(
show subtarget assignments
)
8
cloned
No
y0931
22124839
hypothetical protein y0931 [Yersinia pes...
281
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
3SHO
12.8%
Yersinia pestis
IDP90775
(
show subtarget assignments
)
8
cloned
No
YPO0345
16120680
dipZ
thiol:disulfide interchange protein prec...
595
Predicted Essential
Community Requests
1UC7
12.8%
Yersinia pestis
IDP02246
(
show subtarget assignments
)
1
expressed
No
FTT0649c
56707771
rnfB
Iron-sulfur cluster-binding protein [Fra...
209
Drug Target
Phase 3: June 2008
1GT8
12.9%
Francisella tularensis
Energy metabolism
Electron transport
IDP04189
(
show subtarget assignments
)
1
expressed
No
CPF_0225
110799110
sensor histidine kinase [Clostridium per...
476
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
13%
Clostridium perfringens
Regulatory functions
Protein interactions
IDP90962
(
show subtarget assignments
)
8
purified
No
VC2750
81544306
GGDEF family protein
849
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
2R6O
13%
Vibrio cholerae
IDP01728
(
show subtarget assignments
)
1
expressed
No
CBU_0840
29541434
asnB-2
asparagine synthetase B, glutamine-hydro...
637
Conserved; Drug target functions
Phase 3: June 2008
1Q15
13%
Coxiella burnetii
Amino acid biosynthesis
Aspartate family
IDP90189
(
show subtarget assignments
)
8
cloned
No
AAM13616.1
20153155
CPXV175 CDS
CPXV175 protein
277
CD47-like putative membrane proteinÂ
Community Requests
2JJS
13%
Cowpox virus
host defense modulator
0
IDP90191
(
show subtarget assignments
)
8
expressed
No
AAM13632.1
20153171
CPXV193 CDS
CPXV193 protein
563
kelch-like protein
Community Requests
3II7
13%
Cowpox virus
conserved hypothetical proteins
0
IDP91682
(
show subtarget assignments
)
8
selected
No
MuHV4gp74
9629629
ORF73
nuclear antigen LANA [Murid herpesvirus ...
314
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1I3Q
13.1%
Murid herpesvirus
IDP91727
(
show subtarget assignments
)
8
selected
No
NP_619527
20336315
BCL2L11
bcl-2-like protein 11 isoform 1 [Homo sa...
198
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2NL9
13.1%
Homo sapiens
IDP01374
(
show subtarget assignments
)
1
purified
No
VC0344
15640371
N-acetylmuramoyl-L-alanine amidase
581
Conserved Gene / Pathway
Phase 2: March 2008
3NE8
13.1%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05083
(
show subtarget assignments
)
1
cloned
No
lmo2444
16804482
-
hypothetical protein lmo2444 [Listeria m...
1310
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3LPO
13.1%
Listeria monocytogenes
Central intermediary metabolism: Other
IDP04284
(
show subtarget assignments
)
1
cloned
No
YPO0808
218927988
general secretion pathway protein L [Yer...
389
putative drug target function;
Phase 4: April 2009
1W97
13.1%
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP01373
(
show subtarget assignments
)
1
soluble
No
VC0335
15640362
NlpD-related protein
382
Drug Target Function
Phase 2: March 2008
3SLU
13.1%
Vibrio cholerae
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP04542
(
show subtarget assignments
)
1
expressed
No
YPO2000
218929110
putative two-component system sensor pro...
463
putative drug target function;
Phase 4: April 2009
3JZ3
13.2%
Yersinia pestis
Regulatory functions
Other
IDP02580
(
show subtarget assignments
)
1
cloned
No
STM0452
16763833
cypD
peptidyl-prolyl cis-trans isomerase (rot...
623
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
2KGJ
13.2%
Salmonella enterica
Protein fate
Protein folding and stabilization
IDP02255
(
show subtarget assignments
)
1
cloned
No
FTT1130c
56708207
cphA
cyanophycin synthetase [Francisella tula...
940
Drug Target
Phase 3: June 2008
2WTZ
13.3%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
OtherNitrogen metabolism
IDP04433
(
show subtarget assignments
)
1
cloned
No
GBAA5276
47530584
sensor histidine kinase [Bacillus anthra...
480
putative drug target function;
Phase 4: April 2009
3A0R
13.3%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04294
(
show subtarget assignments
)
1
cloned
No
YPO3477
115349102
putative lipid carrier protein [Yersinia...
173
conserved gene; putative drug target function;
Phase 4: April 2009
1C44
13.3%
Yersinia pestis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP90325
(
show subtarget assignments
)
8
cloned
No
CT089
15604808
lcrE
low calcium response E [Chlamydia tracho...
421
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2VJ4
13.3%
Chlamydia trachomatis
IDP91472
(
show subtarget assignments
)
8
cloned
No
VPA1354
28901209
putative type III secretion system EscU ...
352
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3BZP
13.4%
Vibrio parahaemolyticus
IDP00476
(
show subtarget assignments
)
1
soluble
No
YPO0063
161486895
hypothetical protein YPO0063
456
Virulence Associated Factor
Phase 2: March 2008
1I84
13.4%
Yersinia pestis
Cell envelope
Other
IDP02708
(
show subtarget assignments
)
1
cloned
No
lmo0291
16802337
hypothetical protein lmo0291 [Listeria m...
276
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
2DKF
13.4%
Listeria monocytogenes
Cellular processes
Toxin production and resistance
IDP91897
(
show subtarget assignments
)
8
selected
No
SpneCM_010100007685
298255467
oxidoreductase, NAD-binding protein [Str...
396
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
1KRH
13.4%
Streptococcus pneumoniae
IDP90952
(
show subtarget assignments
)
8
soluble
No
UTI89_C2726
122422986
Hypothetical protein yfeA
749
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
13.4%
Escherichia coli
IDP91898
(
show subtarget assignments
)
8
selected
No
SpneCM_010100003105
298254588
amino acid ABC transporter, amino acid-b...
521
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3I6V
13.4%
Streptococcus pneumoniae
IDP02627
(
show subtarget assignments
)
1
soluble
No
Cj1729c
15793032
flgE
flagellar hook protein FlgE [Campylobact...
865
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
3A69
13.4%
Campylobacter jejuni
Cell envelope
Other
IDP04343
(
show subtarget assignments
)
1
expressed
No
YPO2916
218929972
two-component system sensor kinase [Yers...
483
putative drug target function;
Phase 4: April 2009
3A0R
13.5%
Yersinia pestis
Regulatory functions
Other
IDP91619
(
show subtarget assignments
)
8
soluble
No
BAB36095
13362140
ECs2672
hypothetical protein [Escherichia coli O...
379
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1G9U
13.5%
Escherichia coli
IDP04158
(
show subtarget assignments
)
1
expressed
No
VC1088
15641101
sensor histidine kinase [Vibrio cholerae...
534
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3D36
13.5%
Vibrio cholerae
Regulatory functions
Other
IDP00196
(
show subtarget assignments
)
1
cloned
No
YPO1051
16121351
-
putative membrane protein
451
Virulence
Phase 1: October 2007
2ZPL
13.5%
Yersinia pestis
IDP00005
(
show subtarget assignments
)
1
cloned
No
BA_0552
30254078
internalin, putative
1070
Virulence/Drug Target Homolog
Phase 1: October 2007
1M9S
13.5%
Bacillus anthracis
Cellular processes
Pathogenesis
IDP01185
(
show subtarget assignments
)
1
cloned
No
BA_0280
30253775
glycosyl transferase, group 1 family pro...
443
Drug Target Function
Phase 2: March 2008
2JJM
13.5%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP00411
(
show subtarget assignments
)
1
purified
No
YPO0161
16120504
nirB
nitrite reductase
848
Drug Target Function
Phase 2: March 2008
1D7Y
13.6%
Yersinia pestis
Energy metabolism
Electron transport
IDP02751
(
show subtarget assignments
)
1
expressed
No
FTT0634
56707759
hflC
SPFH domain-containing protein/band 7 fa...
308
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
3BK6
13.6%
Francisella tularensis
Protein fateRegulatory functions
Degradation of proteins, peptides, and glycopeptidesProtein interactions
IDP90125
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_038
68449112
kelch-like protein [Monkeypox virus]
485
similar to VACV-COP-F3L, MPXV-ZAI96-C9L
Community Requests
1ZGK
13.6%
Monkeypox virus
IDP90945
(
show subtarget assignments
)
8
purified
No
VP0092
28896866
hypothetical protein VP0092 [Vibrio para...
811
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3HVB
13.7%
Vibrio parahaemolyticus
IDP91768
(
show subtarget assignments
)
8
purified
No
b1128
90111217
ycfD
conserved protein [Escherichia coli str....
373
drug resistance; innate immunity /
E.coli YcfD (MccE-ctd homolog) - YhhY, SpeG, YcaA, YcfD show distant homology to...
Community Requests
4DIQ
13.7%
Escherichia coli
IDP91618
(
show subtarget assignments
)
8
expressed
No
BAB36097
13362142
ECs2674
hypothetical protein [Escherichia coli O...
379
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1G9U
13.7%
Escherichia coli
IDP05656
(
show subtarget assignments
)
1
cloned
No
lmo0171
16802219
-
hypothetical protein lmo0171 [Listeria m...
832
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2OMX
13.7%
Listeria monocytogenes
Cellular processes: Pathogenesis
IDP02278
(
show subtarget assignments
)
1
expressed
No
Cj0045c
15791444
putative iron-binding protein [Campyloba...
240
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
2AWC
13.7%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP04108
(
show subtarget assignments
)
1
expressed
No
YPO0507
115346316
conserved hypothetical protein [Yersinia...
782
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
2P5Z
13.7%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP02526
(
show subtarget assignments
)
1
cloned
No
FTT1600c
56708620
fumA
fumerate hydratase [Francisella tularens...
504
Drug Target
Phase 3: June 2008
2ISB
13.7%
Francisella tularensis
Energy metabolism
TCA cycle
IDP91541
(
show subtarget assignments
)
8
selected
No
TGME49_118680
237841017
3',5'--cyclic-nucleotide phosphodiestera...
812
potential drug target /
Phosphodiesterases are key regulators of cell signalling pathways and are attrac...
Community Requests
3QI3
13.8%
Toxoplasma gondii
IDP91616
(
show subtarget assignments
)
8
soluble
No
BAB36138
13362183
ECs2715
EspF-like protein [Escherichia coli O157...
337
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KXC
13.9%
Escherichia coli
IDP90215
(
show subtarget assignments
)
8
expressed
No
MYXV_gp009
9633800
m006L
m006L, m6
509
contains kelch motifs, similar to MYX-L-m006R
Community Requests
1X2J
13.9%
Myxoma virus
unknown
0
IDP01064
(
show subtarget assignments
)
1
cloned
No
STM3719
16767004
rfaB
UDP-D-galactose:(glucosyl)lipopolysaccha...
359
Essential Gene
Phase 2: March 2008
2JJM
13.9%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP02354
(
show subtarget assignments
)
1
cloned
No
Cj0887c
15792217
flaD
flagellar hook-associated protein [Campy...
750
Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066
Phase 3: June 2008
1UCU
13.9%
Campylobacter jejuni
Cell envelope
Other
IDP04515
(
show subtarget assignments
)
1
expressed
No
CPF_2673
110799735
putative sensor histidine kinase [Clostr...
583
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
13.9%
Clostridium perfringens
Regulatory functions
Protein interactions
IDP90299
(
show subtarget assignments
)
8
selected
No
TGME49_007160
211969665
Toxoplasma gondii bradyzoite SAG2 relate...
364
The Toxoplasma gondii surface is dominated by a large class of GPI-anchored prot...
Community Requests
2JKS
14%
Toxoplasma gondii
IDP02033
(
show subtarget assignments
)
1
cloned
No
Cj1135
15792460
glycosyltransferase [Campylobacter jejun...
515
Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...
Phase 3: June 2008
2Z86
14%
Campylobacter jejuni
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP90196
(
show subtarget assignments
)
8
cloned
No
AAM13643.1
20153182
CPXV204 CDS
CPXV204 protein
501
kelch-like protein
Community Requests
2VPJ
14%
Cowpox virus
conserved hypothetical proteins
0
IDP92113
(
show subtarget assignments
)
8
selected
No
TGME49_118590
237841001
mrp protein, putative [Toxoplasma gondii...
644
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3KB1
14%
Toxoplasma gondii
IDP05169
(
show subtarget assignments
)
1
soluble
No
BA_1952
30256610
NLP/P60 family protein [Bacillus anthrac...
420
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2F68
14%
Bacillus anthracis
Unknown function: General
IDP91424
(
show subtarget assignments
)
8
expressed
No
VV1_0551
27364013
GGDEF domain-containing protein [Vibrio ...
591
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3BRE
14%
Vibrio vulnificus
IDP05565
(
show subtarget assignments
)
1
cloned
No
lmo2505
16804543
spl
peptidoglycan lytic protein P45 [Listeri...
401
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2XIV
14%
Listeria monocytogenes
Viral functions: General
IDP00063
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_4952
30259447
aminoglycoside phosphotransferase family...
263
Virulence
Phase 1: October 2007
3I0O
14.1%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP02632
(
show subtarget assignments
)
1
cloned
No
lmo0582
16802625
iap
P60 extracellular protein, invasion asso...
482
Known virulence-Invasion; Possible Vaccine Candidate; Known Essential Genes; PMI...
Phase 3: June 2008
3H41
14.1%
Listeria monocytogenes
Unclassified
Role category not yet assigned
IDP04672
(
show subtarget assignments
)
1
expressed
No
GBAA1482
47526755
sensor histidine kinase [Bacillus anthra...
603
putative drug target function;
Phase 4: April 2009
3A0R
14.1%
Bacillus anthracis
Regulatory functions
Protein interactions
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