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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
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IDP#
NCBI GI
LOCUS TAG
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Page 3 of 60, showing 100 records out of 5973 total, starting on record 201
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP00203
(
show subtarget assignments
)
1
in_pdb
3T7B
No
YPO3925
16124056
argB
acetylglutamate kinase
257
Virulence
Phase 1: October 2007
3T7B
100%
Yersinia pestis
Transport and binding proteins
Amino acids, peptides and amines
IDP00204
(
show subtarget assignments
)
1
expressed
No
YPO1702
16121962
-
putative membrane protein
450
Virulence
Phase 1: October 2007
Yersinia pestis
Hypothetical proteins
Conserved
IDP00205
(
show subtarget assignments
)
1
cloned
No
YPO1705
16121965
-
tail-specific protease precursor
690
Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...
Phase 1: October 2007
1FC6
15.8%
Yersinia pestis
IDP00206
(
show subtarget assignments
)
1
soluble
No
YPO1706
16121966
-
putative heat shock protein
293
Virulence
Phase 1: October 2007
3CQB
28.7%
Yersinia pestis
Transport and binding proteins
Unknown substrate
IDP00207
(
show subtarget assignments
)
1
soluble
No
YPO1950
16122196
-
putative peptidase
405
Virulence
Phase 1: October 2007
1WN1
23.7%
Yersinia pestis
Hypothetical proteins
Conserved
IDP00208
(
show subtarget assignments
)
1
expressed
No
YPO1979
16122221
-
putative dehydrogenase
338
Virulence
Phase 1: October 2007
2PK3
21.3%
Yersinia pestis
Transport and binding proteins
Amino acids, peptides and amines
IDP00209
(
show subtarget assignments
)
1
soluble
No
YPO2062
16122301
-
putative M23/M37 peptidase-family protei...
417
Virulence
Phase 1: October 2007
2GU1
32.4%
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP00210
(
show subtarget assignments
)
1
crystallized
No
YPO0314
16120652
lexA
LexA repressor
202
Virulence
Phase 1: October 2007
1JHF
91.1%
Yersinia pestis
Transport and binding proteins
Amino acids, peptides and amines
IDP00211
(
show subtarget assignments
)
1
purified
No
YPO2101
16122340
-
hypothetical phage protein
211
Virulence
Phase 1: October 2007
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP00212
(
show subtarget assignments
)
1
expressed
No
YPO2123
16122358
-
putative phage minor tail protein
236
Virulence
Phase 1: October 2007
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP00213
(
show subtarget assignments
)
1
soluble
No
YPO0628
16120954
-
putative translational inhibitor protein...
134
Virulence
Phase 1: October 2007
3I7T
35.1%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00214
(
show subtarget assignments
)
1
expressed
No
YPO2252
16122476
-
putative toxin transport protein
712
Virulence
Phase 1: October 2007
2YL4
26.1%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00215
(
show subtarget assignments
)
1
cloned
No
YPO2295
16122519
-
haloacid dehalogenase-like hydrolase fam...
224
Virulence
Phase 1: October 2007
3ED5
31.6%
Yersinia pestis
Hypothetical proteins
Conserved
IDP00216
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO2310
16122534
-
putative carboxypeptidase
499
Virulence
Phase 1: October 2007
3DWC
48.1%
Yersinia pestis
Regulatory functions
Other
IDP00217
(
show subtarget assignments
)
1
cloned
No
YPO2319
16122543
-
putative pepetidase
278
Virulence
Phase 1: October 2007
1AGJ
24.1%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP00218
(
show subtarget assignments
)
1
expressed
No
YPO2340
16122564
-
conserved hypothetical protein
256
Virulence
Phase 1: October 2007
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP00219
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1938
16122184
-
probable deoR-family transcriptional reg...
256
Virulence
Phase 1: October 2007
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00220
(
show subtarget assignments
)
1
purified
No
YPO2855
16123048
-
putative protease
464
Virulence
Phase 1: October 2007
Yersinia pestis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP00221
(
show subtarget assignments
)
1
soluble
No
YPO0164
16120507
-
putative membrane receptor protein
686
Virulence
Phase 1: October 2007
2HDF
20.1%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00222
(
show subtarget assignments
)
1
cloned
No
YPO3049
16123226
-
putative binding protein-dependent trans...
589
Virulence
Phase 1: October 2007
3DKN
15.3%
Yersinia pestis
IDP00223
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO3054
16123231
-
putative carboxypeptidase
225
Virulence
Phase 1: October 2007
Yersinia pestis
IDP00224
(
show subtarget assignments
)
1
cloned
No
YPO3058
16123235
-
putative membrane protein
288
Virulence
Phase 1: October 2007
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP00225
(
show subtarget assignments
)
1
cloned
No
YPO3069
16123246
-
putative exported protein
486
Virulence
Phase 1: October 2007
3C37
15%
Yersinia pestis
Purines, pyrimidines, nucleosides, and nucleotides
2'-Deoxyribonucleotide metabolism
IDP00226
(
show subtarget assignments
)
1
soluble
No
YPO3938
16124066
glgP
glycogen phosphorylase
815
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 1: October 2007
1EM6
49.9%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00227
(
show subtarget assignments
)
1
expressed
No
YPO3249
16123408
-
putative amino acid hydrolase
430
Virulence
Phase 1: October 2007
3N5F
36%
Yersinia pestis
Hypothetical proteins
Conserved
IDP00228
(
show subtarget assignments
)
1
cloned
No
YPO3388
16123537
-
putative chloride channel protein
441
Virulence
Phase 1: October 2007
1KPL
76.6%
Yersinia pestis
Transcription
Transcription factors
IDP00229
(
show subtarget assignments
)
1
soluble
No
YPO0417
16120750
-
putative O-antigen biosynthesis protein
410
Virulence
Phase 1: October 2007
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00230
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO3444
16123592
-
putative acetyltransferase
167
Virulence
Phase 1: October 2007
2GE3
18%
Yersinia pestis
Biosynthesis of cofactors, prosthetic groups, and carriers
Biotin
IDP00231
(
show subtarget assignments
)
1
soluble
No
YPO3479
16123625
-
putative protease
331
Virulence
Phase 1: October 2007
Yersinia pestis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP00232
(
show subtarget assignments
)
1
cloned
No
YPO3480
16123626
-
conserved hypothetical protein
292
Virulence
Phase 1: October 2007
Yersinia pestis
Transport and binding proteins
Cations and iron carrying compounds
IDP00233
(
show subtarget assignments
)
1
cloned
No
YPO3676
16123819
-
putative phage-related protein
133
Virulence
Phase 1: October 2007
2VO9
25.6%
Yersinia pestis
Hypothetical proteins
Conserved
IDP00251
(
show subtarget assignments
)
1
cloned
No
MVEVgp1
9633623
Murray Valley encephalitis Envelope prot...
407
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
3P54
78.1%
Murray Valley
IDP00252
(
show subtarget assignments
)
1
in_crystallization_trials
No
130516
St. Louis encephalitis virus Envelope pr...
407
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
2I69
70.5%
St. Louis
IDP00253
(
show subtarget assignments
)
1
in_crystallization_trials
No
YFVgp1
9627245
Yellow fever virus Envelope protein
399
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
1P58
43.8%
Yellow fever
IDP00254
(
show subtarget assignments
)
1
in_pdb
3P54
Yes
13272205
Japanese encephalitis virus Envelope pro...
406
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
3P54
98.3%
Japanese encephalitis
IDP00255
(
show subtarget assignments
)
1
selected
No
NP_041725:276-677
9627243
CFA
Cell fusing agent virus Envelope protein...
402
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
3C5X
15.2%
Cell fusing
IDP00256
(
show subtarget assignments
)
1
expressed
No
RBVgp1
21397175
Rio Bravo bat virus Envelope protein
395
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
1URZ
43.2%
Rio Bravo
IDP00257
(
show subtarget assignments
)
1
in_crystallization_trials
No
MODVgp1
20177456
Modoc virus Envelope protein
393
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
1SVB
41%
Modoc virus
IDP00258
(
show subtarget assignments
)
1
in_crystallization_trials
No
MMLVgp1
22550316
Montana myotis leukoencephalitis Envelop...
395
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
1URZ
43.6%
Montana myotis
IDP00259
(
show subtarget assignments
)
1
crystallized
No
CPXV018
30844336
CPXV229 CDS
OMCP protein Cowpox virus
171
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
Cowpox virus
IDP00260
(
show subtarget assignments
)
1
purified
No
AF380138
17529967
N3R
N3R [Monkeypox virus]
176
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
Monkeypox virus
IDP00263
(
show subtarget assignments
)
1
cloned
No
AF180817_1-114
7329982
N/A
Capsid protein (C)
114
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
60.5%
Dengue virus
Unclassified
N/A
IDP00264
(
show subtarget assignments
)
1
expressed
No
NP_056776_2244-2491
159024209
N/A
NS4B
248
possibly RNA replication
Phase 3: June 2008
Dengue virus
Transcription
N/A
IDP00265
(
show subtarget assignments
)
1
selected
No
AAA99437_775-1129
323469
N/A
NS1
355
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP00266
(
show subtarget assignments
)
1
cloned
No
AAX48017_114-279
61652905
N/A
Premembrane/Membrane protein (prM)
166
Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds
Phase 3: June 2008
3C5X
57.2%
Dengue virus
N/A
IDP00267
(
show subtarget assignments
)
1
cloned
No
AAX48017_4-113
61652905
N/A
Capsid protein (C)
111
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
60.4%
Dengue virus
Unclassified
N/A
IDP00268
(
show subtarget assignments
)
1
cloned
No
AAX48017_2488-3387
61652905
N/A
NS5 methyl transferase and RNA polymeras...
900
RNA-dependent RNA polymerase
Phase 3: June 2008
2J7U
54.7%
Dengue virus
Transcription
N/A
IDP00269
(
show subtarget assignments
)
1
cloned
No
AF180817_776-1127
7329982
N/A
NS1
352
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP00270
(
show subtarget assignments
)
1
cloned
No
AF180817_2245-2493
7329982
N/A
NS4B
249
possibly RNA replication
Phase 3: June 2008
Dengue virus
Transcription
N/A
IDP00271
(
show subtarget assignments
)
1
expressed
No
AF180817_115-280
7329982
N/A
Premembrane/Membrane protein (prM)
166
Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds
Phase 3: June 2008
3C5X
59.6%
Dengue virus
N/A
IDP00272
(
show subtarget assignments
)
1
in_pdb
3EGP
3IRC
No
AF180817_281-775
7329982
N/A
Envelope (E)
495
Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...
Phase 1: October 2007
3G7T
78.8%
Dengue virus
N/A
IDP00273
(
show subtarget assignments
)
1
selected
No
AF180817_1476-2094
7329982
N/A
NS3 RNA Helicase
619
Polyprotein processing, RNA replication
Phase 3: June 2008
2WZQ
76.4%
Dengue virus
Transcription
N/A
IDP00274
(
show subtarget assignments
)
1
selected
No
AF180817_2494-3392
7329982
N/A
NS5 methyl transferase and RNA polymeras...
830
RNA-dependent RNA polymerase
Phase 3: June 2008
2J7U
55.5%
Dengue virus
Transcription
N/A
IDP00275
(
show subtarget assignments
)
1
cloned
No
NP_056776_776-1127
159024209
N/A
NS1
352
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP00276
(
show subtarget assignments
)
1
soluble
No
AAA99437_115-280
323469
N/A
Premembrane/Membrane protein (prM)
166
Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds
Phase 3: June 2008
3C5X
56%
Dengue virus
N/A
IDP00277
(
show subtarget assignments
)
1
cloned
No
AAA99437_5-114
323469
N/A
Capsid protein (C)
110
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
57.3%
Dengue virus
Unclassified
N/A
IDP00278
(
show subtarget assignments
)
1
selected
No
AAA99437_1474-2092
323469
N/A
NS3 RNA Helicase
619
Polyprotein processing, RNA replication
Phase 3: June 2008
2VBC
78.9%
Dengue virus
Transcription
N/A
IDP00279
(
show subtarget assignments
)
1
selected
No
AAA99437_2243-2483
323469
N/A
NS4B
241
possibly RNA replication
Phase 3: June 2008
Dengue virus
Transcription
N/A
IDP00280
(
show subtarget assignments
)
1
purified
No
AAX48017_51-545
604449
N/A
Envelope (E)
495
Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...
Phase 3: June 2008
3UAJ
79.2%
Dengue virus
N/A
IDP00281
(
show subtarget assignments
)
1
cloned
No
AAX48017_776-1130
61652905
N/A
NS1
355
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP00282
(
show subtarget assignments
)
1
cloned
No
AAX48017_2243-2483
61652905
N/A
NS4B
241
possibly RNA replication
Phase 3: June 2008
Dengue virus
Transcription
N/A
IDP00300
(
show subtarget assignments
)
1
cloned
No
CBU_1153
548
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 2: March 2008
1GXB
10.4%
Coxiella burnetii
IDP00301
(
show subtarget assignments
)
1
expressed
No
CBU_0983
291
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 2: March 2008
3NVT
10.7%
Coxiella burnetii
IDP00302
(
show subtarget assignments
)
1
expressed
No
CBU_1155
29654460
trpBF
N-(5'phosphoribosyl)anthranilate isomera...
600
Drug Target Function
Phase 2: March 2008
1V8Z
38%
Coxiella burnetii
Amino acid biosynthesis
Aromatic amino acid family
IDP00303
(
show subtarget assignments
)
1
in_crystallization_trials
No
CBU_0035
29653398
beta-ketoacyl synthase
424
Drug Target Function
Phase 2: March 2008
3E60
36.8%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00304
(
show subtarget assignments
)
1
in_crystallization_trials
No
CBU_0038
29653401
3-oxoacyl-(acyl-carrier-protein) synthas...
327
Drug Target Function
Phase 2: March 2008
1UB7
29.6%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00305
(
show subtarget assignments
)
1
cloned
No
CBU_0118
29653476
pbpB
penicillin-binding protein 3
548
Drug Target Function
Phase 2: March 2008
3OC2
45.3%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00306
(
show subtarget assignments
)
1
expressed
No
CBU_0137
29653495
murB
UDP-N-acetylenolpyruvoylglucosamine redu...
316
Drug Target Function
Phase 2: March 2008
3TX1
34.8%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00307
(
show subtarget assignments
)
1
expressed
No
CBU_0142
29653500
lpxC
UDP-3-0-acyl N-acetylglucosamine deacety...
303
Drug Target Function
Phase 2: March 2008
2VES
65.7%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP00308
(
show subtarget assignments
)
1
soluble
No
CBU_0288
29653640
coaD
phosphopantetheine adenylyltransferase
159
Drug Target Function
Phase 2: March 2008
3IKZ
47.8%
Coxiella burnetii
Biosynthesis of cofactors, prosthetic groups, and carriers
Pantothenate and coenzyme A
IDP00309
(
show subtarget assignments
)
1
expressed
No
CBU_0298
29653649
murI
glutamate racemase
280
Drug Target Function
Phase 2: March 2008
2GZM
38.2%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00310
(
show subtarget assignments
)
1
expressed
No
CBU_0493
29653835
fabH
3-oxoacyl-(acyl-carrier-protein) synthas...
319
Drug Target Function
Phase 2: March 2008
1HN9
54.4%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00311
(
show subtarget assignments
)
1
soluble
No
CBU_0494
29653836
fabD
malonyl CoA-acyl carrier protein transac...
313
Drug Target Function
Phase 2: March 2008
3TQE
100%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00312
(
show subtarget assignments
)
1
expressed
No
CBU_0497
29653839
fabF
3-oxoacyl-acyl carrier protein synthase ...
414
Drug Target Function
Phase 2: March 2008
1B3N
60.1%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00313
(
show subtarget assignments
)
1
expressed
No
CBU_0647
29653985
ribA
riboflavin biosynthesis protein RibA
406
Drug Target Function
Phase 2: March 2008
2BZ0
27.1%
Coxiella burnetii
Biosynthesis of cofactors, prosthetic groups, and carriers
Riboflavin, FMN, and FAD
IDP00314
(
show subtarget assignments
)
1
expressed
No
CBU_0751
29654085
murA
UDP-N-acetylglucosamine 1-carboxyvinyltr...
434
Drug Target Function
Phase 2: March 2008
1EJC
57.1%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00315
(
show subtarget assignments
)
1
in_crystallization_trials
No
CBU_0874
29654200
aroC
chorismate synthase
352
Drug Target Function
Phase 2: March 2008
1R52
44.7%
Coxiella burnetii
Amino acid biosynthesis
Aromatic amino acid family
IDP00316
(
show subtarget assignments
)
1
in_crystallization_trials
No
CBU_1152
29654458
trpE
anthranilate synthase component I
463
Drug Target Function
Phase 2: March 2008
1QDL
34.3%
Coxiella burnetii
Amino acid biosynthesis
Aromatic amino acid family
IDP00317
(
show subtarget assignments
)
1
cloned
No
CBU_1887
29655172
ponA
penicillin-binding protein 1A
793
Drug Target Function
Phase 2: March 2008
3UDF
40.4%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00318
(
show subtarget assignments
)
1
cloned
No
CBU_1947
29655231
glmU
UDP-N-acetylglucosamine pyrophosphorylas...
455
Drug Target Function
Phase 2: March 2008
1HV9
51.4%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP00319
(
show subtarget assignments
)
1
expressed
No
CBU_2070
29655348
chorismate mutase, putative
136
Drug Target Function
Phase 2: March 2008
Coxiella burnetii
Amino acid biosynthesis
Aromatic amino acid family
IDP00320
(
show subtarget assignments
)
1
expressed
No
CBU_0550
29653890
pbpA
penicillin-binding protein 2
612
Drug Target Function
Phase 2: March 2008
1MWR
25.3%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00321
(
show subtarget assignments
)
1
in_crystallization_trials
No
Cj1105
15792430
smpB
SsrA-binding protein
150
Drug Target Function
Phase 2: March 2008
1P6V
47.3%
Campylobacter jejuni
Purines, pyrimidines, nucleosides, and nucleotides
Pyrimidine ribonucleotide biosynthesis
IDP00322
(
show subtarget assignments
)
1
expressed
No
Cj0346
15791714
trpD
anthranilate synthase component II
533
Drug Target Function
Phase 2: March 2008
1VQU
20.6%
Campylobacter jejuni
Amino acid biosynthesis
Aromatic amino acid family
IDP00323
(
show subtarget assignments
)
1
crystallized
No
Cj0858c
15792196
murA
UDP-N-acetylglucosamine 1-carboxyvinyltr...
418
Drug Target Function
Phase 2: March 2008
1NAW
49%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP00324
(
show subtarget assignments
)
1
cloned
No
Cj1366c
15792689
glmS
D-fructose-6-phosphate amidotransferase ...
598
Drug Target Function
Phase 2: March 2008
1JXA
41.3%
Campylobacter jejuni
Unclassified
Unclassified
IDP00325
(
show subtarget assignments
)
1
crystallized
No
Cj1530
15792838
coaE
dephospho-CoA kinase
201
Drug Target Function
Phase 2: March 2008
2IF2
32.8%
Campylobacter jejuni
Unclassified
Unclassified
IDP00326
(
show subtarget assignments
)
0
work_stopped
No
Cj1607
15792912
ispDF
bifunctional 2-C-methyl-D-erythritol 4-p...
371
Drug Target Function
Phase 2: March 2008
1W55
100%
Campylobacter jejuni
Amino acid biosynthesis
Histidine family
IDP00327
(
show subtarget assignments
)
0
work_stopped
No
Cj1634c
15792939
aroC
chorismate synthase
362
Drug Target Function
Phase 2: March 2008
1SQ1
100%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP00328
(
show subtarget assignments
)
1
in_pdb
3UHP
3UHF
3UHO
No
Cj1652c
15792957
murI
glutamate racemase
250
Drug Target Function
Phase 2: March 2008
2JFX
53.7%
Campylobacter jejuni
Energy metabolism
Pentose phosphate pathway
IDP00329
(
show subtarget assignments
)
1
cloned
No
Cj1724c
15793027
7-cyano-7-deazaguanine reductase
127
Drug Target Function
Phase 2: March 2008
Campylobacter jejuni
Amino acid biosynthesis
Pyruvate family
IDP00330
(
show subtarget assignments
)
1
purified
No
Cj0345
15791713
trpE
putative anthranilate synthase component...
416
Drug Target Function
Phase 2: March 2008
1QDL
32%
Campylobacter jejuni
Amino acid biosynthesis
Aromatic amino acid family
IDP00331
(
show subtarget assignments
)
1
in_pdb
3RE3
Yes
FTT1128
56708205
ispF
2C-methyl-D-erythritol 2,4-cyclodiphosph...
159
Drug Target Function
Phase 2: March 2008
3RE3
100%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP00332
(
show subtarget assignments
)
1
purified
No
FTT1673
56708683
ribA
riboflavin biosynthesis protein ribA/GTP...
403
Drug Target Function
Phase 2: March 2008
1G57
27%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Riboflavin, FMN, and FAD
IDP00333
(
show subtarget assignments
)
1
crystallized
No
FTT1487
56708526
coaE
Dephospho-CoA kinase
204
Drug Target Function
Phase 2: March 2008
1JJV
31.4%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Pantothenate and coenzyme A
IDP00334
(
show subtarget assignments
)
1
in_pdb
3LYL
No
FTT1375
56708428
fabG
3-oxoacyl-(acyl-carrier-protein) reducta...
247
Drug Target Function
Phase 2: March 2008
3LYL
100%
Francisella tularensis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00335
(
show subtarget assignments
)
1
in_pdb
3OUT
No
FTT1197c
56708260
murI
glutamate racemase
265
Drug Target Function
Phase 2: March 2008
3OUT
100%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00336
(
show subtarget assignments
)
1
cloned
No
FTT1186
56708252
smpB
SsrA-binding protein
157
Drug Target Function
Phase 2: March 2008
1P6V
48.4%
Francisella tularensis
Protein synthesis
Other
IDP00337
(
show subtarget assignments
)
1
expressed
No
FTT0946
56708043
trpG
anthranilate synthase component II
184
Drug Target Function
Phase 2: March 2008
1QDL
40.7%
Francisella tularensis
Amino acid biosynthesis
Aromatic amino acid family
IDP00338
(
show subtarget assignments
)
1
cloned
No
FTT0876c
56707980
aroC
chorismate synthase
352
Drug Target Function
Phase 2: March 2008
1UM0
47.4%
Francisella tularensis
Amino acid biosynthesis
Aromatic amino acid family
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