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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 3 of 60, showing 100 records out of 5973 total, starting on record 201
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP91403
(
show subtarget assignments
)
8
expressed
No
VV1_0950
27364390
integral membrane protein [Vibrio vulnif...
86
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP05395
(
show subtarget assignments
)
1
cloned
No
BA_2942
30257534
putative lipoprotein [Bacillus anthracis...
86
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP90576
(
show subtarget assignments
)
8
soluble
No
VC0679
15640698
rpsT
30S ribosomal protein S20 [Vibrio choler...
86
Predicted Essential
Community Requests
1VS5
70.9%
Vibrio cholerae
IDP01801
(
show subtarget assignments
)
1
in_pdb
3MSZ
3LGC
No
FTT0533c
56707666
grxA
glutaredoxin 1 [Francisella tularensis s...
86
Drug Target
Phase 3: June 2008
3LGC
100%
Francisella tularensis
Energy metabolism
Electron transport
IDP01227
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_4268
30258770
ptsH-1
phosphocarrier protein HPr
87
Conserved Gene / Pathway
Phase 2: March 2008
1Y4Y
72.4%
Bacillus anthracis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP04100
(
show subtarget assignments
)
1
cloned
No
YPCD1.45
16082733
yscS
needle complex export protein [Yersinia ...
88
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP04315
(
show subtarget assignments
)
1
expressed
No
YPCD1.93
5832508
YPCD1.93
putative transposase [Yersinia pestis CO...
88
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP91532
(
show subtarget assignments
)
8
selected
No
TC_0728
7190757
omcA
OmcA [Chlamydia muridarum Nigg]
88
vaccine candidate /
Vaccine formulation
Community Requests
Chlamydia muridarum
IDP91671
(
show subtarget assignments
)
8
selected
No
VK03_VACCC
0
88
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1LUZ
98.9%
Vaccinia virus
IDP04559
(
show subtarget assignments
)
8
selected
No
CAC05871
12329140
ospE1
OspE1, secreted by the Mxi-Spa secretion...
88
Shigella effector protein
Community Requests
Shigella flexneri
IDP91500
(
show subtarget assignments
)
8
cloned
No
VP1673
28898447
translocation protein in type III secret...
88
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP02126
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT1221
56708283
hypothetical protein FTT1221 [Francisell...
88
Drug Target
Phase 3: June 2008
Francisella tularensis
Cell envelopeRegulatory functions,Unknown function
Biosynthesis and degradation of murein sacculus and peptidoglycanOther,General
IDP90423
(
show subtarget assignments
)
8
cloned
No
CT_444
3328876
omcA
9kDa-Cysteine-Rich Lipoprotein [Chlamydi...
88
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00625
(
show subtarget assignments
)
1
cloned
No
SACOL2404
57285135
addiction module toxin, Txe/YoeB family ...
88
Virulence Associated Factor
Phase 2: March 2008
2A6Q
51.1%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP02660
(
show subtarget assignments
)
1
soluble
No
GBAA4615
47778313
hypothetical protein GBAA4615 [Bacillus ...
88
Conserved; Involved in sporulation;
Phase 3: June 2008
Bacillus anthracis
Hypothetical proteins
Conserved
IDP00619
(
show subtarget assignments
)
1
cloned
No
SACOL2464
57286459
addiction module toxin, Txe/YoeB family ...
88
Virulence Associated Factor
Phase 2: March 2008
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP91630
(
show subtarget assignments
)
8
cloned
No
BAB35233
13361275
ECs1810
hypothetical protein [Escherichia coli O...
88
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP90187
(
show subtarget assignments
)
8
cloned
No
AAM13490.1
20153029
CPXV043 CDS
CPXV043 protein
88
IFN resistance, K3L like
Community Requests
1LUZ
90.9%
Cowpox virus
host defense modulator
0
IDP01955
(
show subtarget assignments
)
1
cloned
No
STM1980
16765318
fliQ
flagellar biosynthesis protein FliQ [Sal...
89
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP05619
(
show subtarget assignments
)
1
cloned
No
CD0664B
126698243
hypothetical protein CD0664B [Clostridiu...
89
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP02552
(
show subtarget assignments
)
1
expressed
No
CBU_0743
29541343
ptsH
phosphocarrier protein HPr [Coxiella bur...
89
Conserved; Drug target functions
Phase 3: June 2008
3LE1
46.1%
Coxiella burnetii
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP05500
(
show subtarget assignments
)
1
cloned
No
CD0261
126697833
fliQ
flagellar export protein [Clostridium di...
89
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP04324
(
show subtarget assignments
)
1
purified
No
CPF_2814
110799621
regulatory protein SpoVG [Clostridium pe...
90
conserved gene; putative drug target function;
Phase 4: April 2009
2IA9
55.6%
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP04601
(
show subtarget assignments
)
1
in_pdb
3RHI
Yes
BAS3574
49186575
DNA-binding protein HU [Bacillus anthrac...
90
Proposed to be essential proteins
Phase 4: April 2009
3RHI
100%
Bacillus anthracis
IDP04250
(
show subtarget assignments
)
1
cloned
No
BAS2213
49185222
DNA-binding protein HU [Bacillus anthrac...
90
Proposed to be essential proteins
Phase 4: April 2009
3RHI
78.9%
Bacillus anthracis
IDP90515
(
show subtarget assignments
)
8
in_pdb
3ULW
No
Cj0884
15792215
rpsO
30S ribosomal protein S15 [Campylobacter...
90
Predicted Essential
Community Requests
3ULW
100%
Campylobacter jejuni
IDP90379
(
show subtarget assignments
)
8
cloned
No
CT_330
3328749
hypothetical protein [Chlamydia trachoma...
90
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP04021
(
show subtarget assignments
)
1
expressed
No
BAS3695
49186694
30S ribosomal protein S16 [Bacillus anth...
90
Proposed to be essential proteins
Phase 4: April 2009
1EMW
42.2%
Bacillus anthracis
IDP04101
(
show subtarget assignments
)
1
purified
No
CPF_2392
110799105
minE
cell division topological specificity fa...
90
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Cell division
IDP01052
(
show subtarget assignments
)
1
expressed
No
STM3324
16766619
ptsO
phosphohistidinoprotein-hexose phosphotr...
90
Conserved Gene / Pathway
Phase 2: March 2008
1JEM
34.4%
Salmonella enterica
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP02072
(
show subtarget assignments
)
1
soluble
No
FTT0554
56707684
hypothetical protein FTT0554 [Francisell...
90
Drug Target
Phase 3: June 2008
4ADZ
35.6%
Francisella tularensis
Energy metabolism
Electron transport
IDP02715
(
show subtarget assignments
)
1
cloned
No
STM3573
16766859
yhhL
hypothetical protein STM3573 [Salmonella...
90
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP01054
(
show subtarget assignments
)
1
purified
No
STM3363
16766658
yhcO
putative cytoplasmic protein
90
Conserved Gene / Pathway
Phase 2: March 2008
2CX6
76.7%
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP05283
(
show subtarget assignments
)
1
soluble
No
CD0229
126697800
flgM
negative regulator of flagellin synthesi...
91
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1RP3
27.5%
Clostridium difficile
Regulatory functions: DNA interactions
IDP91629
(
show subtarget assignments
)
8
expressed
No
BAB34990
13361031
ECs1567
hypothetical protein [Escherichia coli O...
91
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP04310
(
show subtarget assignments
)
1
cloned
No
BAS0231
49183264
D-alanine--D-alanine ligase, C-terminus ...
91
Proposed to be essential proteins
Phase 4: April 2009
2I80
54.9%
Bacillus anthracis
IDP04078
(
show subtarget assignments
)
1
expressed
No
YPCD1.09c
5832432
YPCD1.09c
hypothetical protein YPCD1.09c [Yersinia...
91
virulence factor; conserved gene;
Phase 4: April 2009
3KXE
29.7%
Yersinia pestis
Hypothetical proteins
Conserved
IDP91631
(
show subtarget assignments
)
8
expressed
No
BAB35244
13361286
ECs1821
hypothetical protein [Escherichia coli O...
92
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP90431
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_845
3329317
hypothetical protein [Chlamydia trachoma...
92
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01326
(
show subtarget assignments
)
1
purified
No
VCA0953
15601706
peptidyl-prolyl cis-trans isomerase C
92
Conserved Gene / Pathway
Phase 2: March 2008
1JNS
65.2%
Vibrio cholerae
Protein fate
Protein folding and stabilization
IDP01517
(
show subtarget assignments
)
1
expressed
No
VC1254
15641267
iron-sulfur cluster-binding protein, put...
92
Conserved Gene / Pathway
Phase 2: March 2008
1AWD
26.1%
Vibrio cholerae
Energy metabolism
Electron transport
IDP91059
(
show subtarget assignments
)
8
soluble
No
FTT_1472c
56708512
ppiC
peptidyl-prolyl cis-trans isomerase [Fra...
92
virulence/pathogenesis /
Gene encodes a SurA orthologue which has shown to be important for virulence in ...
Community Requests
1JNS
47.8%
Francisella tularensis
IDP04708
(
show subtarget assignments
)
1
purified
No
BAS0114
49183148
30S ribosomal protein S19 [Bacillus anth...
92
Proposed to be essential proteins
Phase 4: April 2009
1FJG
66.3%
Bacillus anthracis
IDP91357
(
show subtarget assignments
)
8
soluble
No
VV1_2850
27366131
50S ribosomal protein L25 [Vibrio vulnif...
92
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1B75
56.5%
Vibrio vulnificus
IDP91934
(
show subtarget assignments
)
8
selected
No
SpneCM_010100000482
298254075
hypothetical protein SpneCM_00482 [Strep...
92
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP01314
(
show subtarget assignments
)
1
cloned
No
VCA0594
15601353
hemolysin
93
Virulence Associated Factor
Phase 2: March 2008
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01183
(
show subtarget assignments
)
1
purified
No
BA_0266
60389755
10 kDa chaperonin (Protein Cpn10) (groES...
94
Conserved Gene / Pathway
Phase 2: March 2008
1WNR
66%
Bacillus anthracis
Protein fate
Protein folding and stabilization
IDP91508
(
show subtarget assignments
)
8
cloned
No
VP1666
28898440
hypothetical protein VP1666 [Vibrio para...
94
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1XL3
44.7%
Vibrio parahaemolyticus
IDP91312
(
show subtarget assignments
)
8
soluble
No
VP1660
28898434
putative type III secretion regulator [V...
94
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP00616
(
show subtarget assignments
)
1
cloned
No
SACOL1586
57286108
hypothetical protein SACOL1586
94
Drug Target Function
Phase 2: March 2008
Staphylococcus aureus
0
0
IDP00786
(
show subtarget assignments
)
1
soluble
No
SACOL0899
57285775
pathogenicity island protein
94
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
Cellular processes
Pathogenesis
IDP05648
(
show subtarget assignments
)
1
cloned
No
CD3492
126701116
putative septum formation protein [Clost...
94
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Cellular processes: Cell division
IDP02405
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT1803c
56708789
trpR
trp operon repressor [Francisella tulare...
95
Drug Target
Phase 3: June 2008
1CO0
30.5%
Francisella tularensis
Amino acid biosynthesisRegulatory functions
Aromatic amino acid familyDNA interactions
IDP01652
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT1695
56708704
groES
co-chaperonin GroES [Francisella tularen...
95
Conserved; Drug target functions
Phase 3: June 2008
1AON
56.8%
Francisella tularensis
Protein fate
Protein folding and stabilization
IDP90999
(
show subtarget assignments
)
8
cloned
No
y1744
22125639
hypothetical protein y1744 [Yersinia pes...
95
other biological interest /
-
Community Requests
1X7V
33.7%
Yersinia pestis
IDP90359
(
show subtarget assignments
)
8
cloned
No
CT794.1
15605528
hypothetical protein CT794.1 [Chlamydia ...
95
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91890
(
show subtarget assignments
)
8
selected
No
SpneCM_010100006068
298255158
hypothetical protein SpneCM_06068 [Strep...
95
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP02430
(
show subtarget assignments
)
1
expressed
No
FTT1151c
56708222
hypothetical protein FTT1151c [Francisel...
95
Drug Target
Phase 3: June 2008
2JR5
25.3%
Francisella tularensis
Unknown function
General
IDP01519
(
show subtarget assignments
)
1
purified
No
VC2149
15642148
hypothetical protein VC2149
95
Drug Target Function
Phase 2: March 2008
3KE2
43.2%
Vibrio cholerae
IDP00138
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_4159
30258665
conserved hypothetical protein
95
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2ODM
56.8%
Bacillus anthracis
Purines, pyrimidines, nucleosides, and nucleotides
Nucleotide and nucleoside interconversions
IDP01312
(
show subtarget assignments
)
1
crystallized
No
VCA0819
15601574
groES
co-chaperonin GroES
96
Conserved Gene / Pathway
Phase 2: March 2008
1AON
65.6%
Vibrio cholerae
Protein fate
Protein folding and stabilization
IDP90081
(
show subtarget assignments
)
8
cloned
No
ABD79034.1
89892477
M2
matrix protein 2 [Influenza A virus (A/U...
96
Influenza matrix protein 2 (M2) is a validated therapeutic target whose on-marke...
Community Requests
2L0J
42.7%
Influenza A
IDP04311
(
show subtarget assignments
)
1
purified
No
BAS4340
49187335
50S ribosomal protein L27 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1VSA
55.2%
Bacillus anthracis
IDP02694
(
show subtarget assignments
)
1
soluble
No
STM1325
16764676
ydiZ
putative cytoplasmic protein [Salmonella...
96
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP04069
(
show subtarget assignments
)
1
in_pdb
3R3T
Yes
BAS5327
49188311
30S ribosomal protein S6 [Bacillus anthr...
96
Proposed to be essential proteins
Phase 4: April 2009
3R3T
100%
Bacillus anthracis
IDP01690
(
show subtarget assignments
)
1
soluble
No
CBU_1719
29542277
groES
chaperonin, 10 kDa [Coxiella burnetii RS...
96
Conserved; Drug target functions
Phase 3: June 2008
3NX6
58.3%
Coxiella burnetii
Protein fate
Protein folding and stabilization
IDP04584
(
show subtarget assignments
)
1
purified
No
BAS0112
49183146
50S ribosomal protein L23 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1N88
43.8%
Bacillus anthracis
IDP05287
(
show subtarget assignments
)
1
cloned
No
CD0245
126697816
flgB
flagellar basal-body rod protein [Clostr...
97
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP02077
(
show subtarget assignments
)
1
soluble
No
YPO0271
16120610
putative type III secretion apparatus pr...
97
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP01024
(
show subtarget assignments
)
1
purified
No
STM1172
16764528
flgM
anti-sigma28 factor FlgM
97
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Cell envelope
Surface structures
IDP01605
(
show subtarget assignments
)
1
soluble
No
GBAA4560
47529856
hypothetical protein GBAA4560 [Bacillus ...
97
Conserved; Essential; Involved in sporulation;
Phase 3: June 2008
1RQ8
67%
Bacillus anthracis
Hypothetical proteins
Conserved
IDP02233
(
show subtarget assignments
)
1
cloned
No
lmo0056
16802104
hypothetical protein lmo0056 [Listeria m...
97
Predicted virulence-Type III; Type IV; ESAT secretion systems
Phase 3: June 2008
2VRZ
50.5%
Listeria monocytogenes
Hypothetical proteins
Conserved
IDP04060
(
show subtarget assignments
)
8
selected
No
CAC05813
12329082
mxiI
MxiI, component of the Mxi-Spa secretion...
97
Shigella effector protein
Community Requests
Shigella flexneri
IDP04026
(
show subtarget assignments
)
1
expressed
No
FTT0456c
56707598
hypothetical protein FTT_0456c [Francise...
97
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1YHD
39.2%
Francisella tularensis
IDP90407
(
show subtarget assignments
)
8
expressed
No
CT_656
3329106
hypothetical protein [Chlamydia trachoma...
97
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90356
(
show subtarget assignments
)
8
cloned
No
CT080
15604799
ltuB
late transcription unit B protein [Chlam...
97
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01827
(
show subtarget assignments
)
1
expressed
No
Cj0526c
15791887
fliE
flagellar hook-basal body protein FliE [...
98
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Cell envelope
Other
IDP04061
(
show subtarget assignments
)
1
cloned
No
YPCD1.07
5832430
YPCD1.07
hypothetical protein YPCD1.07 [Yersinia ...
98
virulence factor;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP05734
(
show subtarget assignments
)
1
cloned
No
CD1470
126699074
putative phage shock protein [Clostridiu...
99
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3GK5
33.3%
Clostridium difficile
Cellular processes: Adaptations to atypical conditions
IDP04116
(
show subtarget assignments
)
1
expressed
No
Z5122
15804232
sepZ
hypothetical protein Z5122 [Escherichia ...
99
Effector protein
Phase 4: April 2009
Escherichia coli
IDP04288
(
show subtarget assignments
)
1
expressed
No
YPCD1.08c
5832431
YPCD1.08c
hypothetical protein YPCD1.08c [Yersinia...
99
virulence factor; conserved gene;
Phase 4: April 2009
3KXE
28.3%
Yersinia pestis
IDP02105
(
show subtarget assignments
)
1
cloned
No
lmo0063
16802111
hypothetical protein lmo0063 [Listeria m...
99
Predicted virulence-Type III; Type IV; ESAT secretion systems
Phase 3: June 2008
Listeria monocytogenes
Hypothetical proteins
Conserved
IDP90093
(
show subtarget assignments
)
8
expressed
No
ZZZ_0009
99
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP01837
(
show subtarget assignments
)
1
cloned
No
YPO1244
16121530
hypothetical protein YPO1244 [Yersinia p...
99
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
Yersinia pestis
Hypothetical proteins
Conserved
IDP91998
(
show subtarget assignments
)
8
selected
No
SpneCM_010100004262
298254815
bacteriocin, lactococcin 972 family prot...
99
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP05403
(
show subtarget assignments
)
1
soluble
No
BA_4464
30258958
comGC
comG operon protein 3 [Bacillus anthraci...
99
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cellular processes: DNA transformation
IDP00531
(
show subtarget assignments
)
1
cloned
No
YPO2737
16122941
ccmD
putative heme exporter protein D
100
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cellular processes
Other
IDP01852
(
show subtarget assignments
)
1
cloned
No
GBAA5449
47530763
celA-3
PTS system, cellobiose-specific IIB comp...
100
Conserved; Essential; Drug target functions
Phase 3: June 2008
1H9C
41%
Bacillus anthracis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP01818
(
show subtarget assignments
)
1
soluble
No
GBAA5444
47530758
celA-2
PTS system, cellobiose-specific IIB comp...
100
Conserved; Essential; Drug target functions
Phase 3: June 2008
1H9C
42%
Bacillus anthracis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP05707
(
show subtarget assignments
)
1
expressed
No
lmo2762
16804799
-
hypothetical protein lmo2762 [Listeria m...
100
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1H9C
44%
Listeria monocytogenes
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
IDP90982
(
show subtarget assignments
)
8
soluble
No
y0869
22124780
cybC
cytochrome b(562) [Yersinia pestis KIM 1...
100
other biological interest /
uncharacterized periplasmic cytochrome
Community Requests
4ER9
53%
Yersinia pestis
IDP00457
(
show subtarget assignments
)
1
soluble
No
YPO0570
16120899
hypothetical protein YPO0570
101
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cell envelope
Other
IDP01306
(
show subtarget assignments
)
1
purified
No
VC1281
15641294
PTS system, cellobiose-specific IIB comp...
101
Conserved Gene / Pathway
Phase 2: March 2008
2L2Q
40.6%
Vibrio cholerae
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP05443
(
show subtarget assignments
)
1
cloned
No
lmo0463
16802507
-
hypothetical protein lmo0463 [Listeria m...
93
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
Cell envelope: Other
IDP02601
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA2462
47527752
PTS system, cellobiose-specific IIB comp...
101
Conserved; Essential; Drug target functions
Phase 3: June 2008
2L2Q
29.7%
Bacillus anthracis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP01795
(
show subtarget assignments
)
1
expressed
No
GBAA0792
47526077
celA-1
PTS system, cellobiose-specific IIB comp...
101
Conserved; Essential; Drug target functions
Phase 3: June 2008
1H9C
41.6%
Bacillus anthracis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP01715
(
show subtarget assignments
)
1
expressed
No
Cj0351
15791719
fliN
flagellar motor switch protein [Campylob...
102
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
1O6A
29.4%
Campylobacter jejuni
Cell envelope
Other
IDP04617
(
show subtarget assignments
)
1
expressed
No
BAS4342
49187337
50S ribosomal protein L21 [Bacillus anth...
102
Proposed to be essential proteins
Phase 4: April 2009
1VSA
54.9%
Bacillus anthracis
IDP05115
(
show subtarget assignments
)
1
cloned
No
CD2567
126700186
PTS system, IIB component [Clostridium d...
102
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2R48
43.1%
Clostridium difficile
Signal transduction: PTS
IDP04028
(
show subtarget assignments
)
1
purified
No
BAS0109
49183143
30S ribosomal protein S10 [Bacillus anth...
102
Proposed to be essential proteins
Phase 4: April 2009
1P6G
61.8%
Bacillus anthracis
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