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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 3 of 60, showing 100 records out of 5973 total, starting on record 201
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP04350
(
show subtarget assignments
)
1
cloned
No
STM1338_1_795
16764689
pheT
phenylalanyl-tRNA synthetase subunit bet...
795
Salmonella essential protein
Phase 4: April 2009
3PCO
92.6%
Salmonella enterica
IDP04349
(
show subtarget assignments
)
1
expressed
No
STM0557_1_550
16763935
putative inner membrane protein [Salmone...
550
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04357
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0894
56707995
purCD
fusion protein PurC/PurD [Francisella tu...
770
conserved gene; putative drug target function;
Phase 4: April 2009
2YRW
20.3%
Francisella tularensis
IDP04013
(
show subtarget assignments
)
1
cloned
No
STM2913_1_498
16766219
putative permease [Salmonella typhimuriu...
498
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04367
(
show subtarget assignments
)
1
cloned
No
BAS3563
49186564
PTS system, fructose-specific IIABC comp...
622
Proposed to be essential proteins
Phase 4: April 2009
2R4Q
11.4%
Bacillus anthracis
IDP04614
(
show subtarget assignments
)
1
purified
No
BAS4131
49187128
glycine cleavage system aminomethyltrans...
366
Proposed to be essential proteins
Phase 4: April 2009
1YX2
66.1%
Bacillus anthracis
IDP04067
(
show subtarget assignments
)
1
purified
No
BAS4417
49187412
thioredoxin [Bacillus anthracis str. Ste...
104
Proposed to be essential proteins
Phase 4: April 2009
2GZY
75%
Bacillus anthracis
IDP04383
(
show subtarget assignments
)
1
purified
No
BAS4455
49187450
phenylalanyl-tRNA synthetase subunit bet...
806
Proposed to be essential proteins
Phase 4: April 2009
2RHS
49.8%
Bacillus anthracis
IDP04381
(
show subtarget assignments
)
8
selected
No
CAC05791
12329060
unnamed protein product [Shigella flexne...
296
Shigella effector protein
Community Requests
3MKL
8.4%
Shigella flexneri
IDP04380
(
show subtarget assignments
)
1
cloned
No
STM3713_1_404
16766998
rfaL
O-antigen ligase [Salmonella typhimurium...
404
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04396
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS4797
49187787
pyridine nucleotide-disulphide oxidoredu...
331
Proposed to be essential proteins
Phase 4: April 2009
3LZW
76.7%
Bacillus anthracis
IDP04395
(
show subtarget assignments
)
1
cloned
No
FTT0076
56707255
sucA
2-oxoglutarate dehydrogenase E1 componen...
941
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2JGD
47.8%
Francisella tularensis
IDP04414
(
show subtarget assignments
)
8
selected
No
CAC05786
12329055
sepA
SepA, extracellular serine protease of t...
1364
Shigella effector protein
Community Requests
1WXR
34.9%
Shigella flexneri
IDP04415
(
show subtarget assignments
)
8
selected
No
CAC05837
12329106
icsA (virG)
IcsA (VirG), outermembrane protein expos...
1102
Shigella effector protein
Community Requests
3ML3
15.2%
Shigella flexneri
IDP04523
(
show subtarget assignments
)
1
cloned
No
STM0884_1_447
16764245
ulaA
ascorbate-specific PTS system enzyme IIC...
447
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04608
(
show subtarget assignments
)
1
soluble
No
BAS3704
49186703
putative glycerol-3-phosphate acyltransf...
330
Proposed to be essential proteins
Phase 4: April 2009
1VI1
66.4%
Bacillus anthracis
IDP04066
(
show subtarget assignments
)
8
selected
No
CAC05819
12329088
mxiE
MxiE, similarities to transcriptional ac...
210
Shigella effector protein
Community Requests
Shigella flexneri
IDP04417
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0033
56707213
nuoC
NADH dehydrogenase I [Francisella tulare...
216
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2FUG
21.8%
Francisella tularensis
IDP04436
(
show subtarget assignments
)
1
expressed
No
YPCD1.97c
5832512
YPCD1.97c
putative transposase [Yersinia pestis CO...
308
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04613
(
show subtarget assignments
)
1
cloned
No
BAS3890
49186888
M20/M25/M40 family peptidase [Bacillus a...
376
Proposed to be essential proteins
Phase 4: April 2009
1YSJ
35.6%
Bacillus anthracis
IDP04435
(
show subtarget assignments
)
1
expressed
No
YPCD1.91n
40548798
hypothetical protein YPCD1.91n [Yersinia...
154
virulence factor;
Phase 4: April 2009
Yersinia pestis
IDP04520
(
show subtarget assignments
)
1
purified
No
Z0985
15800520
hypothetical protein Z0985 [Escherichia ...
326
Effector protein
Phase 4: April 2009
Escherichia coli
IDP04533
(
show subtarget assignments
)
1
cloned
No
STM4154_1_1407
16767408
rpoC
DNA-directed RNA polymerase subunit beta...
1407
Salmonella essential protein
Phase 4: April 2009
3IYD
98.6%
Salmonella enterica
IDP04069
(
show subtarget assignments
)
1
in_pdb
3R3T
Yes
BAS5327
49188311
30S ribosomal protein S6 [Bacillus anthr...
96
Proposed to be essential proteins
Phase 4: April 2009
3R3T
100%
Bacillus anthracis
IDP04079
(
show subtarget assignments
)
1
purified
No
BAS0100
49183134
50S ribosomal protein L7/L12 [Bacillus a...
119
Proposed to be essential proteins
Phase 4: April 2009
1DD3
63.3%
Bacillus anthracis
IDP04525
(
show subtarget assignments
)
1
cloned
No
STM1556_1_483
16764900
putative Na+/H+ antiporter [Salmonella t...
483
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04527
(
show subtarget assignments
)
1
cloned
No
STM1824_1_454
16765165
pabB
para-aminobenzoate synthase component I ...
454
Salmonella essential protein
Phase 4: April 2009
1K0E
76.2%
Salmonella enterica
IDP04526
(
show subtarget assignments
)
1
expressed
No
STM1637_1_516
16764981
putative inner membrane protein [Salmone...
516
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04528
(
show subtarget assignments
)
1
expressed
No
STM2257_1_289
16765585
napH
quinol dehydrogenase membrane component ...
289
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04529
(
show subtarget assignments
)
1
crystallized
No
STM2481_1_1037
16765801
acrD
aminoglycoside/multidrug efflux system [...
1037
Salmonella essential protein
Phase 4: April 2009
1IWG
66.2%
Salmonella enterica
IDP04535
(
show subtarget assignments
)
8
selected
No
CAC05816
12329085
mxiN
MxiN, putative component of the Mxi-Spa ...
231
Shigella effector protein
Community Requests
Shigella flexneri
IDP04005
(
show subtarget assignments
)
1
purified
No
BAS4355
49187350
valyl-tRNA synthetase [Bacillus anthraci...
881
Proposed to be essential proteins
Phase 4: April 2009
1GAX
42.6%
Bacillus anthracis
IDP04534
(
show subtarget assignments
)
8
selected
No
CAC05815
12329084
mxiK
MxiK, putative component of the Mxi-Spa ...
175
Shigella effector protein
Community Requests
Shigella flexneri
IDP04585
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0116
49183150
30S ribosomal protein S3 [Bacillus anthr...
219
Proposed to be essential proteins
Phase 4: April 2009
1VS5
54.3%
Bacillus anthracis
IDP04536
(
show subtarget assignments
)
8
selected
No
CAC05826
12329095
spa32
Spa32, secreted by and component of the ...
292
Shigella effector protein
Community Requests
Shigella flexneri
IDP04002
(
show subtarget assignments
)
8
selected
No
CAC05806
12329075
ipgA
IpgA, similarities to IpgE, putative cha...
129
Shigella effector protein
Community Requests
Shigella flexneri
IDP05079
(
show subtarget assignments
)
1
cloned
No
lmo1438
16803478
-
hypothetical protein lmo1438 [Listeria m...
721
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2WAE
32.6%
Listeria monocytogenes
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05080
(
show subtarget assignments
)
1
cloned
No
lmo1559
16803599
thrS
threonyl-tRNA synthetase [Listeria monoc...
640
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1NYQ
72%
Listeria monocytogenes
Protein synthesis: tRNA aminoacylation
IDP04070
(
show subtarget assignments
)
1
cloned
No
FTT0073
56707252
sdhD
succinate dehydrogenase hydrophobic memb...
122
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1NEK
26.2%
Francisella tularensis
IDP04555
(
show subtarget assignments
)
1
cloned
No
STM2272_1_878
16765599
gyrA
DNA gyrase subunit A [Salmonella typhimu...
878
Salmonella essential protein
Phase 4: April 2009
3NUH
57.7%
Salmonella enterica
IDP04577
(
show subtarget assignments
)
1
cloned
No
BAS0087
49183121
glutamyl-tRNA synthetase [Bacillus anthr...
485
Proposed to be essential proteins
Phase 4: April 2009
2O5R
44.4%
Bacillus anthracis
IDP04650
(
show subtarget assignments
)
1
expressed
No
FTT1302
56708360
hypothetical protein FTT_1302 [Francisel...
276
drug target; conserved gene;
Phase 4: April 2009
3GBP
88.3%
Francisella tularensis
IDP04539
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05775
12329044
ospD1
OspD1, secreted by the Mxi-Spa secretion...
225
Shigella effector protein
Community Requests
Shigella flexneri
IDP05086
(
show subtarget assignments
)
1
soluble
No
BA_0014
30253529
deoxynucleoside kinase family protein [B...
222
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2A2Z
29.8%
Bacillus anthracis
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
IDP04587
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0118
49183152
50S ribosomal protein L29 [Bacillus anth...
66
Proposed to be essential proteins
Phase 4: April 2009
1R73
45.5%
Bacillus anthracis
IDP04554
(
show subtarget assignments
)
1
cloned
No
STM0791_1_506
16764154
hutH
histidine ammonia-lyase [Salmonella typh...
506
Salmonella essential protein
Phase 4: April 2009
1GK2
76.5%
Salmonella enterica
IDP04558
(
show subtarget assignments
)
8
selected
No
CAC05811
12329080
mxiG
MxiG, component of the Mxi-Spa secretion...
371
Shigella effector protein
Community Requests
4A4Y
34%
Shigella flexneri
IDP04003
(
show subtarget assignments
)
1
cloned
No
BAS0126
49183160
50S ribosomal protein L18 [Bacillus anth...
120
Proposed to be essential proteins
Phase 4: April 2009
1OVY
75.8%
Bacillus anthracis
IDP04559
(
show subtarget assignments
)
8
selected
No
CAC05871
12329140
ospE1
OspE1, secreted by the Mxi-Spa secretion...
88
Shigella effector protein
Community Requests
Shigella flexneri
IDP04571
(
show subtarget assignments
)
1
cloned
No
BAS0002
49183041
DNA polymerase III subunit beta [Bacillu...
379
Proposed to be essential proteins
Phase 4: April 2009
2AWA
42%
Bacillus anthracis
IDP04575
(
show subtarget assignments
)
1
cloned
No
BAS0037
49183072
methionyl-tRNA synthetase [Bacillus anth...
660
Proposed to be essential proteins
Phase 4: April 2009
4DLP
36.2%
Bacillus anthracis
IDP04573
(
show subtarget assignments
)
1
crystallized
No
BAS0006
49183045
DNA gyrase subunit A [Bacillus anthracis...
823
Proposed to be essential proteins
Phase 4: April 2009
2XCO
42.9%
Bacillus anthracis
IDP04574
(
show subtarget assignments
)
1
soluble
No
BAS0015
49183051
seryl-tRNA synthetase [Bacillus anthraci...
424
Proposed to be essential proteins
Phase 4: April 2009
2DQ3
57.8%
Bacillus anthracis
IDP05091
(
show subtarget assignments
)
1
cloned
No
CD0256
126697828
motA
chemotaxis protein [Clostridium difficil...
272
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP04077
(
show subtarget assignments
)
1
crystallized
No
FTT1793c
56708781
pepN
aminopeptidase N [Francisella tularensis...
864
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2DQ6
48.9%
Francisella tularensis
IDP04024
(
show subtarget assignments
)
1
cloned
No
BAS5319
49188303
DNA-binding response regulator YycF [Bac...
235
Proposed to be essential proteins
Phase 4: April 2009
2OQR
47.7%
Bacillus anthracis
IDP04071
(
show subtarget assignments
)
1
cloned
No
BAS0129
49183163
50S ribosomal protein L15 [Bacillus anth...
146
Proposed to be essential proteins
Phase 4: April 2009
1VSA
51.4%
Bacillus anthracis
IDP04075
(
show subtarget assignments
)
8
selected
No
CAC05807
12329076
icsB
IcsB, function unknown [Shigella flexner...
494
Shigella effector protein
Community Requests
Shigella flexneri
IDP04089
(
show subtarget assignments
)
1
expressed
No
STM1952_1_222
16765290
yecS
putative ABC-type amino acid transporter...
222
Salmonella essential protein
Phase 4: April 2009
2R6G
24.3%
Salmonella enterica
IDP04081
(
show subtarget assignments
)
1
purified
No
BAS0361
49183389
DNA topoisomerase III [Bacillus anthraci...
729
Proposed to be essential proteins
Phase 4: April 2009
1D6M
27.7%
Bacillus anthracis
IDP04098
(
show subtarget assignments
)
1
cloned
No
YPCD1.50
5832470
YPCD1.50
hypothetical protein YPCD1.50 [Yersinia ...
32
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04106
(
show subtarget assignments
)
1
cloned
No
BAS0124
49183158
30S ribosomal protein S8 [Bacillus anthr...
132
Proposed to be essential proteins
Phase 4: April 2009
1SEI
85.6%
Bacillus anthracis
IDP04015
(
show subtarget assignments
)
1
purified
No
VC0395
15640422
UTP--glucose-1-phosphate uridylyltransfe...
291
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3JUJ
58.1%
Vibrio cholerae
Purines, pyrimidines, nucleosides, and nucleotides
IDP04119
(
show subtarget assignments
)
1
crystallized
No
BAS0131
49183165
adenylate kinase [Bacillus anthracis str...
216
Proposed to be essential proteins
Phase 4: April 2009
1ZIN
74.1%
Bacillus anthracis
IDP04117
(
show subtarget assignments
)
8
selected
No
CAC05825
12329094
spa13
spa13, component of the Mxi-Spa secretio...
112
Shigella effector protein
Community Requests
Shigella flexneri
IDP04625
(
show subtarget assignments
)
1
cloned
No
BAS5050
49188036
glycosyl transferase, group 4 family pro...
357
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP04135
(
show subtarget assignments
)
1
cloned
No
BAS4470
49187465
50S ribosomal protein L35 [Bacillus anth...
66
Proposed to be essential proteins
Phase 4: April 2009
1VS6
48.5%
Bacillus anthracis
IDP04120
(
show subtarget assignments
)
1
soluble
No
BAS1475
49184492
xanthine phosphoribosyltransferase [Baci...
197
Proposed to be essential proteins
Phase 4: April 2009
1Y0B
65%
Bacillus anthracis
IDP04137
(
show subtarget assignments
)
1
soluble
No
BAS0134
49183168
50S ribosomal protein L36 [Bacillus anth...
37
Proposed to be essential proteins
Phase 4: April 2009
1DFE
81.1%
Bacillus anthracis
IDP04584
(
show subtarget assignments
)
1
purified
No
BAS0112
49183146
50S ribosomal protein L23 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1N88
43.8%
Bacillus anthracis
IDP04030
(
show subtarget assignments
)
1
cloned
No
YPO2532
115348229
hypothetical protein [Yersinia pestis CO...
70
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04026
(
show subtarget assignments
)
1
expressed
No
FTT0456c
56707598
hypothetical protein FTT_0456c [Francise...
97
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1YHD
39.2%
Francisella tularensis
IDP04064
(
show subtarget assignments
)
1
expressed
No
BAS0127
49183161
30S ribosomal protein S5 [Bacillus anthr...
166
Proposed to be essential proteins
Phase 4: April 2009
1PKP
75.3%
Bacillus anthracis
IDP04215
(
show subtarget assignments
)
1
cloned
No
STM1574_1_495
16764918
smvA
methyl viologen resistance [Salmonella t...
495
Salmonella essential protein
Phase 4: April 2009
2GFP
17%
Salmonella enterica
IDP04211
(
show subtarget assignments
)
1
expressed
No
STM0408_1_323
16763788
secF
preprotein translocase subunit SecF [Sal...
323
Salmonella essential protein
Phase 4: April 2009
3AQP
35.3%
Salmonella enterica
IDP04028
(
show subtarget assignments
)
1
purified
No
BAS0109
49183143
30S ribosomal protein S10 [Bacillus anth...
102
Proposed to be essential proteins
Phase 4: April 2009
1P6G
61.8%
Bacillus anthracis
IDP04213
(
show subtarget assignments
)
1
cloned
No
STM1003_1_478
16764363
putative transcriptional regulator [Salm...
478
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04212
(
show subtarget assignments
)
1
cloned
No
STM0646_1_343
16764023
holA
DNA polymerase III subunit delta [Salmon...
343
Salmonella essential protein
Phase 4: April 2009
1JQJ
89.8%
Salmonella enterica
IDP04216
(
show subtarget assignments
)
1
cloned
No
STM1894_1_336
16765236
ruvB
Holliday junction DNA helicase B [Salmon...
336
Salmonella essential protein
Phase 4: April 2009
1HQC
53%
Salmonella enterica
IDP04046
(
show subtarget assignments
)
1
cloned
No
YPCD1.78c
16082765
tap
repA translation protein [Yersinia pesti...
24
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04217
(
show subtarget assignments
)
1
cloned
No
STM2619_1_203
16765939
hypothetical protein STM2619 [Salmonella...
203
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04222
(
show subtarget assignments
)
8
selected
No
CAC05827
12329096
spa33
Spa33, component of the Mxi-Spa secretio...
293
Shigella effector protein
Community Requests
Shigella flexneri
IDP04218
(
show subtarget assignments
)
1
expressed
No
STM2996_1_1123
16766298
recC
exonuclease V subunit gamma [Salmonella ...
1123
Salmonella essential protein
Phase 4: April 2009
1W36
88.4%
Salmonella enterica
IDP04027
(
show subtarget assignments
)
1
cloned
No
BAS4637
49187628
leucyl-tRNA synthetase [Bacillus anthrac...
802
Proposed to be essential proteins
Phase 4: April 2009
1H3N
45.9%
Bacillus anthracis
IDP04612
(
show subtarget assignments
)
1
cloned
No
BAS3764
49186763
phospho-N-acetylmuramoyl-pentapeptide-tr...
324
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP04581
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0108
49183142
elongation factor Tu [Bacillus anthracis...
395
Proposed to be essential proteins
Phase 4: April 2009
3U2Q
75.4%
Bacillus anthracis
IDP04074
(
show subtarget assignments
)
1
cloned
No
BAS4469
49187464
50S ribosomal protein L20 [Bacillus anth...
118
Proposed to be essential proteins
Phase 4: April 2009
1VS6
55.1%
Bacillus anthracis
IDP04602
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS3667
49186666
transcription elongation factor NusA [Ba...
368
Proposed to be essential proteins
Phase 4: April 2009
1HH2
44%
Bacillus anthracis
IDP04045
(
show subtarget assignments
)
1
soluble
No
FTT1747
56708745
outer membrane protein [Francisella tula...
191
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Francisella tularensis
IDP04277
(
show subtarget assignments
)
1
cloned
No
BAS3960
49186958
PTS system, glucose-specific IIABC compo...
687
Proposed to be essential proteins
Phase 4: April 2009
1AX3
14.7%
Bacillus anthracis
IDP04227
(
show subtarget assignments
)
1
expressed
No
CPF_0198
110799765
sensory box histidine kinase [Clostridiu...
791
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
11.6%
Clostridium perfringens
Regulatory functions
IDP04224
(
show subtarget assignments
)
8
selected
No
CAC05802
12329071
ipaC
IpaC, secreted by the Mxi-Spa secretion ...
363
Shigella effector protein
Community Requests
Shigella flexneri
IDP04732
(
show subtarget assignments
)
1
cloned
No
BAS5341
49188325
50S ribosomal protein L34 [Bacillus anth...
44
Proposed to be essential proteins
Phase 4: April 2009
1NKW
65.9%
Bacillus anthracis
IDP04225
(
show subtarget assignments
)
8
cloned
No
CAC05803
12329072
ipaB
IpaB, secreted by the Mxi-Spa secretion ...
580
Shigella effector protein
Community Requests
3U0C
34.3%
Shigella flexneri
IDP04618
(
show subtarget assignments
)
1
cloned
No
BAS4456
49187451
phenylalanyl-tRNA synthetase subunit alp...
344
Proposed to be essential proteins
Phase 4: April 2009
2RHQ
57.6%
Bacillus anthracis
IDP04624
(
show subtarget assignments
)
1
in_pdb
3B2B
3UWD
No
BAS4988
49187974
phosphoglycerate kinase [Bacillus anthra...
394
Proposed to be essential proteins
Phase 4: April 2009
3B2B
99.7%
Bacillus anthracis
IDP04591
(
show subtarget assignments
)
1
cloned
No
BAS0138
49183172
50S ribosomal protein L17 [Bacillus anth...
120
Proposed to be essential proteins
Phase 4: April 2009
1NKW
50.8%
Bacillus anthracis
IDP04035
(
show subtarget assignments
)
1
in_pdb
3P0R
Yes
BAS5262
49188247
azoreductase [Bacillus anthracis str. St...
208
Proposed to be essential proteins
Phase 4: April 2009
3P0R
100%
Bacillus anthracis
IDP05099
(
show subtarget assignments
)
1
cloned
No
CD0754
126698334
thiI
thiamine biosynthesis protein ThiI [Clos...
391
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2C5S
42.2%
Clostridium difficile
Protein synthesis: tRNA and rRNA base modification
IDP05098
(
show subtarget assignments
)
1
purified
No
CD0569
126698147
putative outer membrane lipoprotein [Clo...
334
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2FQW
21.3%
Clostridium difficile
Cell envelope: Other
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