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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 3 of 60, showing 100 records out of 5973 total, starting on record 201
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP91235
(
show subtarget assignments
)
8
soluble
No
NT04EC1225
26107466
3-oxoacyl-[acyl-carrier protein] reducta...
243
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
4DML
44.4%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP05774
(
show subtarget assignments
)
1
in_pdb
3OSU
No
SAV1231
15924221
fabG
3-oxoacyl-(acyl-carrier protein) reducta...
246
potential drug target /
Potential drug target
Phase 5: 2010
3OSU
100%
Staphylococcus aureus
IDP91221
(
show subtarget assignments
)
8
soluble
No
SAV1231
15924221
fabG
3-oxoacyl-(acyl-carrier protein) reducta...
246
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3OSU
100%
Staphylococcus aureus
IDP91302
(
show subtarget assignments
)
8
soluble
No
STM2378
16765705
fabB
3-oxoacyl-(acyl carrier protein) synthas...
404
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1FJ4
96.8%
Salmonella enterica
IDP91296
(
show subtarget assignments
)
8
cloned
No
STM1193
16764548
fabH
3-oxoacyl-(acyl carrier protein) synthas...
317
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1HN9
94.6%
Salmonella enterica
IDP01493
(
show subtarget assignments
)
1
diffraction
No
VCA0751
161582040
3-oxoacyl-(acyl carrier protein) synthas...
362
Drug Target Function
Phase 2: March 2008
2EBD
40.9%
Vibrio cholerae
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01192
(
show subtarget assignments
)
1
purified
No
BA_1184
34098435
3-oxoacyl-[acyl-carrier-protein] synthas...
310
Drug Target Function
Phase 2: March 2008
1ZOW
61%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01201
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_1826
34098434
3-oxoacyl-[acyl-carrier-protein] synthas...
327
Drug Target Function
Phase 2: March 2008
1UB7
40.7%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00577
(
show subtarget assignments
)
1
in_pdb
3OYT
Yes
YPO2757
16122961
fabB
3-oxoacyl-(acyl carrier protein) synthas...
407
Virulence Associated Factor
Phase 2: March 2008
3OYT
100%
Yersinia pestis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP91229
(
show subtarget assignments
)
8
soluble
No
NT04EC2950
26109117
fabB
3-oxoacyl-[acyl-carrier-protein] synthas...
363
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1DD8
100%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP00409
(
show subtarget assignments
)
1
purified
No
YPO1601
16121869
fabF
3-oxoacyl-(acyl carrier protein) synthas...
413
Conserved Gene / Pathway
Phase 2: March 2008
1B3N
89.1%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP01439
(
show subtarget assignments
)
1
crystallized
No
VC2019
15642021
3-oxoacyl-(acyl carrier protein) synthas...
414
Drug Target Function
Phase 2: March 2008
1B3N
74.9%
Vibrio cholerae
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01193
(
show subtarget assignments
)
1
purified
No
BA_1185
30254899
fabF
3-oxoacyl-(acyl-carrier-protein) synthas...
412
Drug Target Function
Phase 2: March 2008
3O04
67.7%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00312
(
show subtarget assignments
)
1
expressed
No
CBU_0497
29653839
fabF
3-oxoacyl-acyl carrier protein synthase ...
414
Drug Target Function
Phase 2: March 2008
1B3N
60.1%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP90856
(
show subtarget assignments
)
8
crystallized
No
Cj0442
15791809
fabF
3-oxoacyl-(acyl carrier protein) synthas...
404
Predicted Essential
Community Requests
1J3N
52.7%
Campylobacter jejuni
IDP00353
(
show subtarget assignments
)
1
in_crystallization_trials
No
lmo2202
16804241
3-oxoacyl-(acyl carrier protein) synthas...
312
Drug Target Function
Phase 2: March 2008
1ZOW
58.1%
Listeria monocytogenes
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00541
(
show subtarget assignments
)
1
purified
No
YPO1597
16121865
fabH
3-oxoacyl-(acyl carrier protein) synthas...
316
Conserved Gene / Pathway
Phase 2: March 2008
1HN9
81.1%
Yersinia pestis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01441
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC2023
15642025
3-oxoacyl-(acyl carrier protein) synthas...
316
Drug Target Function
Phase 2: March 2008
1EBL
72.6%
Vibrio cholerae
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00310
(
show subtarget assignments
)
1
expressed
No
CBU_0493
29653835
fabH
3-oxoacyl-(acyl-carrier-protein) synthas...
319
Drug Target Function
Phase 2: March 2008
1HN9
54.4%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP91237
(
show subtarget assignments
)
8
cloned
No
NT04EC1409
26107632
fabH
3-oxoacyl-[acyl-carrier-protein] synthas...
317
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1HN9
100%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP01213
(
show subtarget assignments
)
1
expressed
No
BA_3251
30257808
3-oxoacyl-(acyl-carrier-protein) synthas...
329
Drug Target Function
Phase 2: March 2008
2EBD
34.7%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00304
(
show subtarget assignments
)
1
in_crystallization_trials
No
CBU_0038
29653401
3-oxoacyl-(acyl-carrier-protein) synthas...
327
Drug Target Function
Phase 2: March 2008
1UB7
29.6%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP91291
(
show subtarget assignments
)
8
expressed
No
SPA1658
56413821
fabH
3-oxoacyl-(acyl carrier protein) synthas...
317
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1HN9
94.6%
Salmonella enterica
IDP91287
(
show subtarget assignments
)
8
soluble
No
SPA0486
56412725
fabB
3-oxoacyl-(acyl carrier protein) synthas...
404
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1FJ4
96.8%
Salmonella enterica
IDP91255
(
show subtarget assignments
)
8
soluble
No
NT02SA0971
14246752
fabH
3-oxoacyl-#acyl-carrier protein synthase...
313
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1ZOW
100%
Staphylococcus aureus
Fatty acid and phospholipid metabolism: Biosynthesis
IDP91256
(
show subtarget assignments
)
8
cloned
No
NT02SA0972
14246753
3-oxoacyl synthase [Staphylococcus aureu...
414
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2GQD
99.8%
Staphylococcus aureus
Energy metabolism: ATP-proton motive force interconversion
IDP90165
(
show subtarget assignments
)
8
purified
No
CD1834
123174271
3-phosphoshikimate 1-carboxyvinyltransfe...
437
Potential drug target. Shikimate pathway enzyme
Community Requests
3NVS
32.5%
Clostridium difficile
IDP00946
(
show subtarget assignments
)
1
expressed
No
STM0978
16764338
aroA
3-phosphoshikimate 1-carboxyvinyltransfe...
427
Conserved Gene / Pathway
Phase 2: March 2008
1G6S
89.5%
Salmonella enterica
Amino acid biosynthesis
Aromatic amino acid family
IDP00012
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_2953
61211623
3-phosphoshikimate 1-carboxyvinyltransfe...
429
Drug Target Homolog
Phase 1: October 2007
3RMT
66.2%
Bacillus anthracis
Amino acid biosynthesis
Aromatic amino acid family
IDP91208
(
show subtarget assignments
)
8
purified
No
BT_2186
29347596
3-phosphoshikimate 1-carboxyvinyltransfe...
410
potential drug target /
Shikimate pathway enzyme
Community Requests
1EPS
36.2%
Bacteroides thetaiotaomicron
IDP91212
(
show subtarget assignments
)
8
cloned
No
BLIJ_1793
189439586
aroA
3-phosphoshikimate 1-carboxyvinyltransfe...
445
potential drug target /
Shikimate pathway enzyme
Community Requests
2BJB
44.9%
Bifidobacterium longum
IDP01842
(
show subtarget assignments
)
1
in_pdb
3SLH
4EGR
3ROI
Yes
CBU_0526
29541129
aroA
3-phosphoshikimate 1-carboxyvinyltransfe...
438
Conserved; Drug target functions
Phase 3: June 2008
3ROI
100%
Coxiella burnetii
Amino acid biosynthesis
Aromatic amino acid family
IDP90626
(
show subtarget assignments
)
8
in_pdb
3TI2
3NVS
No
VC1732
15641736
3-phosphoshikimate 1-carboxyvinyltransfe...
426
Predicted Essential
Community Requests
3NVS
100%
Vibrio cholerae
IDP90726
(
show subtarget assignments
)
8
purified
No
YPO1390
16121670
aroA
3-phosphoshikimate 1-carboxyvinyltransfe...
428
Predicted Essential
Community Requests
1G6S
80.1%
Yersinia pestis
IDP92090
(
show subtarget assignments
)
8
selected
No
TGME49_121570
237844801
(3R)-hydroxymyristoyl ACP dehydrase, put...
231
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1Z6B
35.9%
Toxoplasma gondii
IDP04453
(
show subtarget assignments
)
1
cloned
No
YPO1055
115346834
fabZ
(3R)-hydroxymyristoyl-(acyl carrier prot...
181
conserved gene; putative drug target function;
Phase 4: April 2009
1U1Z
44.2%
Yersinia pestis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP90338
(
show subtarget assignments
)
8
cloned
No
CT087
15604806
malQ
4-alpha-glucanotransferase [Chlamydia tr...
527
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2X1I
25.2%
Chlamydia trachomatis
IDP02073
(
show subtarget assignments
)
1
expressed
No
CBU_0418
29541027
4-amino-4-deoxychorismate lyase, putativ...
281
Conserved; Drug target functions
Phase 3: June 2008
3LUL
28.1%
Coxiella burnetii
Biosynthesis of cofactors, prosthetic groups, and carriers
Folic acid
IDP90908
(
show subtarget assignments
)
8
crystallized
No
STM1198
16764553
pabC
4-amino-4-deoxychorismate lyase [Salmone...
269
Predicted Essential
Community Requests
1ET0
69.9%
Salmonella enterica
IDP90852
(
show subtarget assignments
)
8
expressed
No
VC2018
15642020
4-amino-4-deoxychorismate lyase [Vibrio ...
277
Predicted Essential
Community Requests
1ET0
34.3%
Vibrio cholerae
IDP90912
(
show subtarget assignments
)
8
purified
No
YPO1603
16121871
4-amino-4-deoxychorismate lyase [Yersini...
268
Predicted Essential
Community Requests
1ET0
56%
Yersinia pestis
IDP01016
(
show subtarget assignments
)
1
cloned
No
STM2792
16766103
gabT
4-aminobutyrate aminotransferase
427
Conserved Gene / Pathway
Phase 2: March 2008
1SF2
88.3%
Salmonella enterica
Central intermediary metabolism
Other
IDP02716
(
show subtarget assignments
)
1
cloned
No
GBAA0325
47525592
gabT
4-aminobutyrate aminotransferase [Bacill...
454
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
1SF2
45.2%
Bacillus anthracis
Central intermediary metabolism
Other
IDP90649
(
show subtarget assignments
)
8
cloned
No
Cj1104
15792429
4-diphosphocytidyl-2-C-methyl-D-erythrit...
255
Predicted Essential
Community Requests
2V2Q
29%
Campylobacter jejuni
IDP90942
(
show subtarget assignments
)
8
expressed
No
A55_2372
124113375
ispE
4-diphosphocytidyl-2C-methyl-D-erythrito...
194
We have identified the methylerythritol phosphate (MEP) pathway enzymes, novel d...
Community Requests
1OJ4
59.8%
Vibrio cholerae
IDP90543
(
show subtarget assignments
)
8
cloned
No
VC2182
15642181
ipk
4-diphosphocytidyl-2-C-methyl-D-erythrit...
295
Predicted Essential
Community Requests
1OJ4
58%
Vibrio cholerae
IDP90560
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO2014
16122257
ipk
4-diphosphocytidyl-2-C-methyl-D-erythrit...
299
Predicted Essential
Community Requests
1OJ4
70.9%
Yersinia pestis
IDP04483
(
show subtarget assignments
)
1
expressed
No
YPO3361
115348990
b2747
4-diphosphocytidyl-2C-methyl-D-erythrito...
241
conserved gene; putative drug target function;
Phase 4: April 2009
1VGT
63.5%
Yersinia pestis
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP90760
(
show subtarget assignments
)
8
expressed
No
Cj0686
15792035
ispG
4-hydroxy-3-methylbut-2-en-1-yl diphosph...
357
Predicted Essential
Community Requests
3NOY
47.1%
Campylobacter jejuni
IDP90683
(
show subtarget assignments
)
8
purified
No
YPO2879
16123071
ispG
4-hydroxy-3-methylbut-2-en-1-yl diphosph...
375
Predicted Essential
Community Requests
3NOY
43.5%
Yersinia pestis
IDP00062
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_4511
50400989
4-hydroxy-3-methylbut-2-enyl diphosphate...
316
Virulence
Phase 1: October 2007
3F7T
35.4%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP90896
(
show subtarget assignments
)
8
cloned
No
YPO0477
16120807
ispH
4-hydroxy-3-methylbut-2-enyl diphosphate...
317
Predicted Essential
Community Requests
3F7T
82.7%
Yersinia pestis
IDP90904
(
show subtarget assignments
)
8
cloned
No
YPO0311
16120649
ubiA
4-hydroxybenzoate octaprenyltransferase ...
288
Predicted Essential
Community Requests
Yersinia pestis
IDP02463
(
show subtarget assignments
)
1
expressed
No
YPO1769
16122023
hpaB
4-hydroxyphenylacetate 3-monooxygenase [...
520
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
2YYG
28.1%
Yersinia pestis
Fatty acid and phospholipid metabolism
Degradation
IDP00949
(
show subtarget assignments
)
1
purified
No
STM1102
16764460
hpaE
4-hydroxyphenylacetate catabolism
488
Conserved Gene / Pathway
Phase 2: March 2008
2D4E
47.7%
Salmonella enterica
Central intermediary metabolism
Other
IDP90645
(
show subtarget assignments
)
8
in_pdb
3TSN
No
Cj1239
15792563
pdxA
4-hydroxythreonine-4-phosphate dehydroge...
364
Predicted Essential
Community Requests
3TSN
100%
Campylobacter jejuni
IDP90915
(
show subtarget assignments
)
8
in_pdb
3LXY
Yes
YPO0493
16120823
pdxA
4-hydroxythreonine-4-phosphate dehydroge...
331
Predicted Essential
Community Requests
3LXY
100%
Yersinia pestis
IDP04323
(
show subtarget assignments
)
1
in_pdb
3OT1
No
VC2308
15642306
4-methyl-5(B-hydroxyethyl)-thiazole mono...
205
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3OT1
100%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Thiamine
IDP02642
(
show subtarget assignments
)
1
cloned
No
GBAA5626
47778419
4-oxalocrotonate tautomerase [Bacillus a...
61
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
2OP8
78.7%
Bacillus anthracis
Energy metabolism
Other
IDP01461
(
show subtarget assignments
)
1
in_pdb
3H88
No
VC2457
15642453
acpS
4'-phosphopantetheinyl transferase
126
Drug Target Function
Phase 2: March 2008
3H88
100%
Vibrio cholerae
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00407
(
show subtarget assignments
)
1
purified
No
YPO2929
16123116
acpS
4'-phosphopantetheinyl transferase
126
Virulence Associated Factor
Phase 2: March 2008
3H88
53.2%
Yersinia pestis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP91377
(
show subtarget assignments
)
8
cloned
No
VV1_1569
27364938
acpS
4'-phosphopantetheinyl transferase [Vibr...
126
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3OTA
73%
Vibrio vulnificus
IDP02424
(
show subtarget assignments
)
1
cloned
No
FTT1147c
56708218
dfp
4'-phosphopantothenoylcysteine decarboxy...
391
Conserved; Drug target functions
Phase 3: June 2008
1U7U
19.4%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Pantothenate and coenzyme A
IDP04592
(
show subtarget assignments
)
1
expressed
No
BAS0143
49183177
50S ribosomal protein L13 [Bacillus anth...
145
Proposed to be essential proteins
Phase 4: April 2009
1P85
56.6%
Bacillus anthracis
IDP04107
(
show subtarget assignments
)
1
purified
No
BAS0120
49183154
50S ribosomal protein L14 [Bacillus anth...
122
Proposed to be essential proteins
Phase 4: April 2009
1C04
86.9%
Bacillus anthracis
IDP04071
(
show subtarget assignments
)
1
cloned
No
BAS0129
49183163
50S ribosomal protein L15 [Bacillus anth...
146
Proposed to be essential proteins
Phase 4: April 2009
1VSA
51.4%
Bacillus anthracis
IDP04586
(
show subtarget assignments
)
1
cloned
No
BAS0117
49183151
50S ribosomal protein L16 [Bacillus anth...
144
Proposed to be essential proteins
Phase 4: April 2009
1VSA
60.4%
Bacillus anthracis
IDP04591
(
show subtarget assignments
)
1
cloned
No
BAS0138
49183172
50S ribosomal protein L17 [Bacillus anth...
120
Proposed to be essential proteins
Phase 4: April 2009
1NKW
50.8%
Bacillus anthracis
IDP04003
(
show subtarget assignments
)
1
cloned
No
BAS0126
49183160
50S ribosomal protein L18 [Bacillus anth...
120
Proposed to be essential proteins
Phase 4: April 2009
1OVY
75.8%
Bacillus anthracis
IDP04570
(
show subtarget assignments
)
1
soluble
No
FTT0153
56707323
rplS
50S ribosomal protein L19 [Francisella t...
115
drug target; conserved gene;
Phase 4: April 2009
1VS6
58.3%
Francisella tularensis
Protein synthesis
Ribosomal proteins: synthesis and modification
IDP04579
(
show subtarget assignments
)
1
cloned
No
BAS0098
49183132
50S ribosomal protein L1 [Bacillus anthr...
230
Proposed to be essential proteins
Phase 4: April 2009
3QOY
56.3%
Bacillus anthracis
IDP04074
(
show subtarget assignments
)
1
cloned
No
BAS4469
49187464
50S ribosomal protein L20 [Bacillus anth...
118
Proposed to be essential proteins
Phase 4: April 2009
1VS6
55.1%
Bacillus anthracis
IDP04617
(
show subtarget assignments
)
1
expressed
No
BAS4342
49187337
50S ribosomal protein L21 [Bacillus anth...
102
Proposed to be essential proteins
Phase 4: April 2009
1VSA
54.9%
Bacillus anthracis
IDP91418
(
show subtarget assignments
)
8
expressed
No
VV1_0671
27364128
rplU
50S ribosomal protein L21 [Vibrio vulnif...
103
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1VS6
78.6%
Vibrio vulnificus
IDP04339
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0115
49183149
50S ribosomal protein L22 [Bacillus anth...
113
Proposed to be essential proteins
Phase 4: April 2009
1BXE
59.3%
Bacillus anthracis
IDP04584
(
show subtarget assignments
)
1
purified
No
BAS0112
49183146
50S ribosomal protein L23 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1N88
43.8%
Bacillus anthracis
IDP91357
(
show subtarget assignments
)
8
soluble
No
VV1_2850
27366131
50S ribosomal protein L25 [Vibrio vulnif...
92
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1B75
56.5%
Vibrio vulnificus
IDP04311
(
show subtarget assignments
)
1
purified
No
BAS4340
49187335
50S ribosomal protein L27 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1VSA
55.2%
Bacillus anthracis
IDP04587
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0118
49183152
50S ribosomal protein L29 [Bacillus anth...
66
Proposed to be essential proteins
Phase 4: April 2009
1R73
45.5%
Bacillus anthracis
IDP04707
(
show subtarget assignments
)
1
cloned
No
BAS0113
49183147
50S ribosomal protein L2 [Bacillus anthr...
276
Proposed to be essential proteins
Phase 4: April 2009
1VSA
65%
Bacillus anthracis
IDP04034
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0128
49183162
50S ribosomal protein L30 [Bacillus anth...
60
Proposed to be essential proteins
Phase 4: April 2009
1VS6
53.3%
Bacillus anthracis
IDP04732
(
show subtarget assignments
)
1
cloned
No
BAS5341
49188325
50S ribosomal protein L34 [Bacillus anth...
44
Proposed to be essential proteins
Phase 4: April 2009
1NKW
65.9%
Bacillus anthracis
IDP04135
(
show subtarget assignments
)
1
cloned
No
BAS4470
49187465
50S ribosomal protein L35 [Bacillus anth...
66
Proposed to be essential proteins
Phase 4: April 2009
1VS6
48.5%
Bacillus anthracis
IDP04137
(
show subtarget assignments
)
1
soluble
No
BAS0134
49183168
50S ribosomal protein L36 [Bacillus anth...
37
Proposed to be essential proteins
Phase 4: April 2009
1DFE
81.1%
Bacillus anthracis
IDP04582
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0110
49183144
50S ribosomal protein L3 [Bacillus anthr...
210
Proposed to be essential proteins
Phase 4: April 2009
1NKW
53.3%
Bacillus anthracis
IDP04583
(
show subtarget assignments
)
1
cloned
No
BAS0111
49183145
50S ribosomal protein L4 [Bacillus anthr...
207
Proposed to be essential proteins
Phase 4: April 2009
1DMG
47.1%
Bacillus anthracis
IDP04340
(
show subtarget assignments
)
1
cloned
No
BAS0122
49183156
50S ribosomal protein L5 [Bacillus anthr...
179
Proposed to be essential proteins
Phase 4: April 2009
1IQ4
85.5%
Bacillus anthracis
IDP04057
(
show subtarget assignments
)
1
purified
No
BAS0125
49183159
50S ribosomal protein L6 [Bacillus anthr...
179
Proposed to be essential proteins
Phase 4: April 2009
1C04
74.9%
Bacillus anthracis
IDP05764
(
show subtarget assignments
)
1
in_crystallization_trials
No
lmo2617
16804655
rplF
50S ribosomal protein L6 [Listeria monoc...
178
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1C04
73%
Listeria monocytogenes
Protein synthesis: Ribosomal proteins: synthesis and modification
IDP04079
(
show subtarget assignments
)
1
purified
No
BAS0100
49183134
50S ribosomal protein L7/L12 [Bacillus a...
119
Proposed to be essential proteins
Phase 4: April 2009
1DD3
63.3%
Bacillus anthracis
IDP04628
(
show subtarget assignments
)
1
soluble
No
BAS5322
49188306
50S ribosomal protein L9 [Bacillus anthr...
148
Proposed to be essential proteins
Phase 4: April 2009
1DIV
75%
Bacillus anthracis
IDP90569
(
show subtarget assignments
)
8
soluble
No
VC0369
15640396
rplI
50S ribosomal protein L9 [Vibrio cholera...
149
Predicted Essential
Community Requests
1P85
76.5%
Vibrio cholerae
IDP00584
(
show subtarget assignments
)
1
soluble
No
YPO0117
16120462
metF
5,10-methylenetetrahydrofolate reductase...
294
Virulence Associated Factor
Phase 2: March 2008
1ZP3
86.4%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP90670
(
show subtarget assignments
)
8
soluble
No
Cj1202
15792526
metF
5,10-methylenetetrahydrofolate reductase...
282
Predicted Essential
Community Requests
1V93
34%
Campylobacter jejuni
IDP90647
(
show subtarget assignments
)
8
cloned
No
VC2685
15642680
metF
5,10-methylenetetrahydrofolate reductase...
304
Predicted Essential
Community Requests
1ZP3
75.3%
Vibrio cholerae
IDP04050
(
show subtarget assignments
)
1
purified
No
YPO1765
218928887
hpaF
5-carboxymethyl-2-hydroxymuconate delta-...
132
conserved gene; putative drug target function;
Phase 4: April 2009
1OTG
67.4%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP02345
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT1220
56708282
5-formyltetrahydroformate cycloligase fa...
182
Drug Target
Phase 3: June 2008
2JCB
28.6%
Francisella tularensis
Unclassified
Role category not yet assigned
IDP02487
(
show subtarget assignments
)
1
cloned
No
GBAA4218
47529511
metE
5-methyltetrahydropteroyltriglutamate--h...
762
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
2NQ5
51.3%
Bacillus anthracis
Amino acid biosynthesis
Aspartate family
IDP02212
(
show subtarget assignments
)
1
cloned
No
CBU_2048
29542599
metE
5-methyltetrahydropteroyltriglutamate--h...
775
Conserved; Drug target functions
Phase 3: June 2008
1U1H
48.5%
Coxiella burnetii
Amino acid biosynthesis
Aspartate family
IDP04136
(
show subtarget assignments
)
1
diffraction
No
GBAA4258
47529551
5-methylthio-3-oxo-1-penten-1,2-diol dio...
170
putative drug target function;
Phase 4: April 2009
1ZRR
31.8%
Bacillus anthracis
Amino acid biosynthesis
Aspartate family
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