Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00204 (show subtarget assignments)	1	expressed	No	YPO1702	16121962	-	putative membrane protein	450	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP00205 (show subtarget assignments)	1	cloned	No	YPO1705	16121965	-	tail-specific protease precursor	690	Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...	Phase 1: October 2007	1FC6	15.8%	Yersinia pestis

IDP00206 (show subtarget assignments)	1	soluble	No	YPO1706	16121966	-	putative heat shock protein	293	Virulence	Phase 1: October 2007	3CQB	28.7%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00207 (show subtarget assignments)	1	soluble	No	YPO1950	16122196	-	putative peptidase	405	Virulence	Phase 1: October 2007	1WN1	23.7%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00208 (show subtarget assignments)	1	expressed	No	YPO1979	16122221	-	putative dehydrogenase	338	Virulence	Phase 1: October 2007	2PK3	21.3%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00209 (show subtarget assignments)	1	soluble	No	YPO2062	16122301	-	putative M23/M37 peptidase-family protei...	417	Virulence	Phase 1: October 2007	2GU1	32.4%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP00210 (show subtarget assignments)	1	crystallized	No	YPO0314	16120652	lexA	LexA repressor	202	Virulence	Phase 1: October 2007	1JHF	91.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00211 (show subtarget assignments)	1	purified	No	YPO2101	16122340	-	hypothetical phage protein	211	Virulence	Phase 1: October 2007			Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP00212 (show subtarget assignments)	1	expressed	No	YPO2123	16122358	-	putative phage minor tail protein	236	Virulence	Phase 1: October 2007			Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP00213 (show subtarget assignments)	1	soluble	No	YPO0628	16120954	-	putative translational inhibitor protein...	134	Virulence	Phase 1: October 2007	3I7T	35.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00045 (show subtarget assignments)	1	purified	No	BA_3111	30257692		aminoglycoside phosphotransferase family...	292	Virulence	Phase 1: October 2007	3LZH	17.8%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00215 (show subtarget assignments)	1	cloned	No	YPO2295	16122519	-	haloacid dehalogenase-like hydrolase fam...	224	Virulence	Phase 1: October 2007	3ED5	31.6%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00216 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2310	16122534	-	putative carboxypeptidase	499	Virulence	Phase 1: October 2007	3DWC	48.1%	Yersinia pestis	Regulatory functions	Other

IDP00217 (show subtarget assignments)	1	cloned	No	YPO2319	16122543	-	putative pepetidase	278	Virulence	Phase 1: October 2007	1AGJ	24.1%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP00218 (show subtarget assignments)	1	expressed	No	YPO2340	16122564	-	conserved hypothetical protein	256	Virulence	Phase 1: October 2007			Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP00219 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1938	16122184	-	probable deoR-family transcriptional reg...	256	Virulence	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00220 (show subtarget assignments)	1	purified	No	YPO2855	16123048	-	putative protease	464	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00221 (show subtarget assignments)	1	soluble	No	YPO0164	16120507	-	putative membrane receptor protein	686	Virulence	Phase 1: October 2007	2HDF	20.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00181 (show subtarget assignments)	1	soluble	No	YPO0363	16120698	-	putative membrane transport protein	1119	Similar to Essential SALTY	Phase 1: October 2007	2OAU	5%	Yersinia pestis	DNA metabolism	DNA replication, recombination, and repair

IDP00223 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3054	16123231	-	putative carboxypeptidase	225	Virulence	Phase 1: October 2007			Yersinia pestis

IDP00224 (show subtarget assignments)	1	cloned	No	YPO3058	16123235	-	putative membrane protein	288	Virulence	Phase 1: October 2007			Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP00225 (show subtarget assignments)	1	cloned	No	YPO3069	16123246	-	putative exported protein	486	Virulence	Phase 1: October 2007	3C37	15%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP00180 (show subtarget assignments)	1	expressed	No	YPO0339	16120675	-	enhancing factor (viral)	856	Virulence	Phase 1: October 2007			Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP00227 (show subtarget assignments)	1	expressed	No	YPO3249	16123408	-	putative amino acid hydrolase	430	Virulence	Phase 1: October 2007	3N5F	36%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00179 (show subtarget assignments)	1	cloned	No	YPO0277	16120616	-	putative transmembrane transport protein...	428	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Unknown function	General

IDP00229 (show subtarget assignments)	1	soluble	No	YPO0417	16120750	-	putative O-antigen biosynthesis protein	410	Virulence	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00230 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3444	16123592	-	putative acetyltransferase	167	Virulence	Phase 1: October 2007	2GE3	18%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00231 (show subtarget assignments)	1	soluble	No	YPO3479	16123625	-	putative protease	331	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00232 (show subtarget assignments)	1	cloned	No	YPO3480	16123626	-	conserved hypothetical protein	292	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00233 (show subtarget assignments)	1	cloned	No	YPO3676	16123819	-	putative phage-related protein	133	Virulence	Phase 1: October 2007	2VO9	25.6%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00178 (show subtarget assignments)	1	soluble	No	YPO3405	16123554	-	putative ABC transporter, integral membr...	256	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00252 (show subtarget assignments)	1	in_crystallization_trials	No		130516		St. Louis encephalitis virus Envelope pr...	407	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	2I69	70.5%	St. Louis

IDP00253 (show subtarget assignments)	1	in_crystallization_trials	No	YFVgp1	9627245		Yellow fever virus Envelope protein	399	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1P58	43.8%	Yellow fever

IDP00254 (show subtarget assignments)	1	in_pdb 3P54	Yes		13272205		Japanese encephalitis virus Envelope pro...	406	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	3P54	98.3%	Japanese encephalitis

IDP00255 (show subtarget assignments)	1	selected	No	NP_041725:276-677	9627243	CFA	Cell fusing agent virus Envelope protein...	402	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	3C5X	15.2%	Cell fusing

IDP00256 (show subtarget assignments)	1	expressed	No	RBVgp1	21397175		Rio Bravo bat virus Envelope protein	395	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1URZ	43.2%	Rio Bravo

IDP00257 (show subtarget assignments)	1	in_crystallization_trials	No	MODVgp1	20177456		Modoc virus Envelope protein	393	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1SVB	41%	Modoc virus

IDP00258 (show subtarget assignments)	1	in_crystallization_trials	No	MMLVgp1	22550316		Montana myotis leukoencephalitis Envelop...	395	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1URZ	43.6%	Montana myotis

IDP00259 (show subtarget assignments)	1	crystallized	No	CPXV018	30844336	CPXV229 CDS	OMCP protein Cowpox virus	171	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007			Cowpox virus

IDP00260 (show subtarget assignments)	1	purified	No	AF380138	17529967	N3R	N3R [Monkeypox virus]	176	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007			Monkeypox virus

IDP00263 (show subtarget assignments)	1	cloned	No	AF180817_1-114	7329982	N/A	Capsid protein (C)	114	Encapsidation of genomic RNA	Phase 3: June 2008	1R6R	60.5%	Dengue virus	Unclassified	N/A

IDP00264 (show subtarget assignments)	1	expressed	No	NP_056776_2244-2491	159024209	N/A	NS4B	248	possibly RNA replication	Phase 3: June 2008			Dengue virus	Transcription	N/A

IDP00265 (show subtarget assignments)	1	selected	No	AAA99437_775-1129	323469	N/A	NS1	355	Secreted from infected cells; stimulates protective immune responses (reason for...	Phase 3: June 2008			Dengue virus	host defense modulator	N/A

IDP00266 (show subtarget assignments)	1	cloned	No	AAX48017_114-279	61652905	N/A	Premembrane/Membrane protein (prM)	166	Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds	Phase 3: June 2008	3C5X	57.2%	Dengue virus		N/A

IDP00267 (show subtarget assignments)	1	cloned	No	AAX48017_4-113	61652905	N/A	Capsid protein (C)	111	Encapsidation of genomic RNA	Phase 3: June 2008	1R6R	60.4%	Dengue virus	Unclassified	N/A

IDP00268 (show subtarget assignments)	1	cloned	No	AAX48017_2488-3387	61652905	N/A	NS5 methyl transferase and RNA polymeras...	900	RNA-dependent RNA polymerase	Phase 3: June 2008	2J7U	54.7%	Dengue virus	Transcription	N/A

IDP00044 (show subtarget assignments)	1	in_pdb 3SLB 3SLF 3E4F 3IJW 3N0S 3KZL 3N0M	Yes	BA_2930	30257522	aacC7	aminoglycoside N3-acetyltransferase	265	Virulence	Phase 1: October 2007	3E4F	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00270 (show subtarget assignments)	1	cloned	No	AF180817_2245-2493	7329982	N/A	NS4B	249	possibly RNA replication	Phase 3: June 2008			Dengue virus	Transcription	N/A

IDP00022 (show subtarget assignments)	1	cloned	No	BA_5578	81714842		UDP-N-acetylglucosamine 1-carboxyvinyltr...	429	Drug Target Homolog	Phase 1: October 2007	3SG1	49.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00272 (show subtarget assignments)	1	in_pdb 3EGP 3IRC	No	AF180817_281-775	7329982	N/A	Envelope (E)	495	Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...	Phase 1: October 2007	3G7T	78.8%	Dengue virus		N/A

IDP00273 (show subtarget assignments)	1	selected	No	AF180817_1476-2094	7329982	N/A	NS3 RNA Helicase	619	Polyprotein processing, RNA replication	Phase 3: June 2008	2WZQ	76.4%	Dengue virus	Transcription	N/A

IDP00274 (show subtarget assignments)	1	selected	No	AF180817_2494-3392	7329982	N/A	NS5 methyl transferase and RNA polymeras...	830	RNA-dependent RNA polymerase	Phase 3: June 2008	2J7U	55.5%	Dengue virus	Transcription	N/A

IDP00275 (show subtarget assignments)	1	cloned	No	NP_056776_776-1127	159024209	N/A	NS1	352	Secreted from infected cells; stimulates protective immune responses (reason for...	Phase 3: June 2008			Dengue virus	host defense modulator	N/A

IDP00276 (show subtarget assignments)	1	soluble	No	AAA99437_115-280	323469	N/A	Premembrane/Membrane protein (prM)	166	Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds	Phase 3: June 2008	3C5X	56%	Dengue virus		N/A

IDP00011 (show subtarget assignments)	1	soluble	No	BA_2222	30256868		alcohol dehydrogenase, iron-containing	392	Drug Target Homolog	Phase 1: October 2007	3OWO	37.8%	Bacillus anthracis	Energy metabolism	Fermentation

IDP00005 (show subtarget assignments)	1	cloned	No	BA_0552	30254078		internalin, putative	1070	Virulence/Drug Target Homolog	Phase 1: October 2007	1M9S	13.5%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP00177 (show subtarget assignments)	1	purified	No	YPO3007	16123186	-	putative membrane protein	509	Virulence	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00176 (show subtarget assignments)	1	cloned	No	YPO4024	16124147	-	putative iron transport permease	335	Virulence	Phase 1: October 2007	2QI9	23.9%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00087 (show subtarget assignments)	1	expressed	No	NTL01ST2379	16420989	STM2449	putative acetyltransferase	178	Virulence	Phase 1: October 2007	2PDO	75.3%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00175 (show subtarget assignments)	1	soluble	No	YPO1471	16121746	-	putative ATPase subunit of ATP-dependent...	880	Virulence	Phase 1: October 2007	1QVR	36.9%	Yersinia pestis

IDP00174 (show subtarget assignments)	1	cloned	No	YPO1140	16121437	-	putative membrane protein	272	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Unknown function	General

IDP00086 (show subtarget assignments)	1	in_pdb 3DR6 3DR8	No	NT01ST1973	16420114	yncA	putative acyltransferase	171	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DR6	100%	Salmonella enterica	Transport and binding proteins	Other

IDP00043 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2629	30257246		acetyltransferase, CYSE/LACA/LPXA/NODL f...	210	Virulence	Phase 1: October 2007	4E8L	63.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00173 (show subtarget assignments)	1	cloned	No	YPO2922	16123109	-	putative membrane protein	486	Virulence	Phase 1: October 2007	3K4U	14.4%	Yersinia pestis	Unknown function	General

IDP00172 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2438	16122659	-	putative membrane-bound lytic murein tra...	220	Virulence	Phase 1: October 2007	2Y8P	42.7%	Yersinia pestis	Mobile and extrachromosomal element functions	Prophage functions

IDP00085 (show subtarget assignments)	1	in_crystallization_trials	No	NTL01ST1174	16419726	nagZ	putative glycosyl hydrolase	341	Virulence	Phase 1: October 2007	1TR9	55.4%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00171 (show subtarget assignments)	1	cloned	No	YPO0452	16120781	-	putative soluble lytic murein transglyco...	639	Similar to Essential SALTY	Phase 1: October 2007	1QSA	61.8%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00170 (show subtarget assignments)	1	soluble	No	VCA0865	15601620	hap	hemagglutinin/protease	609	Virulence	Phase 1: October 2007	1EZM	31.4%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00084 (show subtarget assignments)	1	expressed	No	NT01ST1435	16419673	yceI	putative secreted protein	191	Essential	Phase 1: October 2007	1Y0G	91.1%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00042 (show subtarget assignments)	1	soluble	No	BA_2507	30257134	bla1	beta-lactamase	309	Virulence	Phase 1: October 2007	3QHY	87.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00021 (show subtarget assignments)	1	in_pdb 3SG1	No	BA_5529	81714862		UDP-N-acetylglucosamine 1-carboxyvinyltr...	434	Drug Target Homolog	Phase 1: October 2007	3SG1	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00169 (show subtarget assignments)	1	expressed	No	VCA0218	15600987	No Data	thermolabile hemolysin	418	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00168 (show subtarget assignments)	1	cloned	No	VC2209	15642774	vibF	nonribosomal peptide synthetase VibF, au...	2413	Virulence	Phase 1: October 2007	2VSQ	10.2%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP00083 (show subtarget assignments)	1	in_crystallization_trials	No	NTL01ST0073	16418570	caiA	putative acyl-CoA dehydrogenase, carniti...	380	Essential	Phase 1: October 2007	2DVL	32.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP00166 (show subtarget assignments)	1	expressed	No	VC1450	15641461	rtxC	RTX toxin activating protein	153	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00041 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2409	30257040		chloramphenicol acetyltransferase	216	Virulence	Phase 1: October 2007	1QCA	41.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00020 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5315	47605857		UDP-N-acetylenolpyruvoylglucosamine redu...	305	Drug Target Homolog	Phase 1: October 2007	1HSK	59.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00165 (show subtarget assignments)	1	cloned	No	VC0844	15640861	acfA	accessory colonization factor AcfA	215	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00164 (show subtarget assignments)	1	soluble	No	VC0841	15640858	acfC	accessory colonization factor AcfC	256	Virulence	Phase 1: October 2007	3FIR	50%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00081 (show subtarget assignments)	1	in_crystallization_trials	No	NT01ST5473	16422973	ytfP	putative cytoplasmic protein	114	Essential	Phase 1: October 2007	1XHS	92.1%	Salmonella enterica	Unknown function	General

IDP00162 (show subtarget assignments)	1	soluble	No	VC0837	15640854	tcpF	toxin co-regulated pilus biosynthesis pr...	338	Virulence	Phase 1: October 2007	3OC5	93.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00080 (show subtarget assignments)	1	expressed	No	NT01ST5073	16422645	yneC	putative inner membrane protein	109	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3QMQ	70.6%	Salmonella enterica	Cell envelope	Other

IDP00040 (show subtarget assignments)	1	purified	No	BA_2042	46395770		Metallothiol transferase fosB 1 (Fosfomy...	138	Virulence	Phase 1: October 2007	3UH9	67.4%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00010 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2144	30256791		uroporphyrin-III C-methyltransferase, pu...	474	Drug Target Homolog	Phase 1: October 2007	1PJQ	24.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00002 (show subtarget assignments)	1	expressed	No	GBAA_pXO1_0079	47566400	-	surface layer protein, (pxo1-54)	404	Drug Target Homolog	Phase 1: October 2007	3PYW	14.4%	Bacillus anthracis

IDP00001 (show subtarget assignments)	1	cloned	No	BA_4599	30259099		aldehyde-alcohol dehydrogenase	867	Drug Target Homolog	Phase 1: October 2007	3MY7	24.5%	Bacillus anthracis	Energy metabolism	Fermentation

IDP00161 (show subtarget assignments)	1	soluble	No	VC0835	15640852	tcpT	toxin co-regulated pilus biosynthesis pr...	503	Virulence	Phase 1: October 2007	1P9R	23.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00160 (show subtarget assignments)	1	soluble	No	VC0834	15640851	tcpS	toxin co-regulated pilus biosynthesis pr...	152	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00079 (show subtarget assignments)	1	in_pdb 3DSA 3E7N	No	NT01ST4845	16422456	rbsD	D-ribose high-affinity transport system ...	139	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DSA	100%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00159 (show subtarget assignments)	1	purified	No	VC0831	15640848	tcpC	toxin co-regulated pilus biosynthesis ou...	489	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00158 (show subtarget assignments)	1	soluble	No	VC0830	15640847	tcpQ	toxin co-regulated pilus biosynthesis pr...	150	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00039 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1960	30256617		aminoglycoside 6-adenylyltransferase, pu...	290	Virulence	Phase 1: October 2007	2PBE	37.9%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00157 (show subtarget assignments)	1	soluble	No	VC0829	15640846	tcpB	toxin co-regulated pilus biosynthesis pr...	430	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00156 (show subtarget assignments)	1	purified	No	VC0407	15640434	mshF	MSHA biogenesis protein MshF	150	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00155 (show subtarget assignments)	1	in_crystallization_trials	No	VC0405	15640432	mshE	MSHA biogenesis protein MshE	575	Virulence	Phase 1: October 2007	1P9R	31.7%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00154 (show subtarget assignments)	1	crystallized	No	VC2448	15642444	pyrG	CTP synthase	545	Essential	Phase 1: October 2007	1S1M	79.5%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00076 (show subtarget assignments)	1	in_pdb 3NX4	No	NT01ST4228	16421936	yhdH	putative oxidoreductase	324	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3NX4	100%	Salmonella enterica	Cellular processes	Cell division

IDP00038 (show subtarget assignments)	1	in_pdb 3SR3 3GJZ 3T5M 3TYX 3U1B	No	BA_1949	30256607		microcin immunity protein MccF	333	Virulence	Phase 1: October 2007	3GJZ	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00019 (show subtarget assignments)	1	cloned	No	BA_4843	30259344	pykA-2	pyruvate kinase	585	Drug Target Homolog	Phase 1: October 2007	2E28	69.6%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00153 (show subtarget assignments)	1	expressed	No	VC0475	15640502	irgA	enterobactin receptor	652	Virulence	Phase 1: October 2007	2HDF	37.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00204
(show subtarget assignments)

1

expressed

No

YPO1702

16121962

-

putative membrane protein

450

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP00205
(show subtarget assignments)

1

cloned

No

YPO1705

16121965

-

tail-specific protease precursor

690

Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...

Phase 1: October 2007

1FC6

15.8%

Yersinia pestis

IDP00206
(show subtarget assignments)

1

soluble

No

YPO1706

16121966

-

putative heat shock protein

293

Virulence

Phase 1: October 2007

3CQB

28.7%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00207
(show subtarget assignments)

1

soluble

No

YPO1950

16122196

-

putative peptidase

405

Virulence

Phase 1: October 2007

1WN1

23.7%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00208
(show subtarget assignments)

1

expressed

No

YPO1979

16122221

-

putative dehydrogenase

338

Virulence

Phase 1: October 2007

2PK3

21.3%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00209
(show subtarget assignments)

1

soluble

No

YPO2062

16122301

-

putative M23/M37 peptidase-family protei...

417

Virulence

Phase 1: October 2007

2GU1

32.4%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP00210
(show subtarget assignments)

1

crystallized

No

YPO0314

16120652

lexA

LexA repressor

202

Virulence

Phase 1: October 2007

1JHF

91.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00211
(show subtarget assignments)

1

purified

No

YPO2101

16122340

-

hypothetical phage protein

211

Virulence

Phase 1: October 2007

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP00212
(show subtarget assignments)

1

expressed

No

YPO2123

16122358

-

putative phage minor tail protein

236

Virulence

Phase 1: October 2007

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP00213
(show subtarget assignments)

1

soluble

No

YPO0628

16120954

-

putative translational inhibitor protein...

134

Virulence

Phase 1: October 2007

3I7T

35.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00045
(show subtarget assignments)

1

purified

No

BA_3111

30257692

aminoglycoside phosphotransferase family...

292

Virulence

Phase 1: October 2007

3LZH

17.8%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00215
(show subtarget assignments)

1

cloned

No

YPO2295

16122519

-

haloacid dehalogenase-like hydrolase fam...

224

Virulence

Phase 1: October 2007

3ED5

31.6%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00216
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2310

16122534

-

putative carboxypeptidase

499

Virulence

Phase 1: October 2007

3DWC

48.1%

Yersinia pestis

Regulatory functions

Other

IDP00217
(show subtarget assignments)

1

cloned

No

YPO2319

16122543

-

putative pepetidase

278

Virulence

Phase 1: October 2007

1AGJ

24.1%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00218
(show subtarget assignments)

1

expressed

No

YPO2340

16122564

-

conserved hypothetical protein

256

Virulence

Phase 1: October 2007

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP00219
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1938

16122184

-

probable deoR-family transcriptional reg...

256

Virulence

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00220
(show subtarget assignments)

1

purified

No

YPO2855

16123048

-

putative protease

464

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00221
(show subtarget assignments)

1

soluble

No

YPO0164

16120507

-

putative membrane receptor protein

686

Virulence

Phase 1: October 2007

2HDF

20.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00181
(show subtarget assignments)

1

soluble

No

YPO0363

16120698

-

putative membrane transport protein

1119

Similar to Essential SALTY

Phase 1: October 2007

2OAU

5%

Yersinia pestis

DNA metabolism

DNA replication, recombination, and repair

IDP00223
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3054

16123231

-

putative carboxypeptidase

225

Virulence

Phase 1: October 2007

Yersinia pestis

IDP00224
(show subtarget assignments)

1

cloned

No

YPO3058

16123235

-

putative membrane protein

288

Virulence

Phase 1: October 2007

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP00225
(show subtarget assignments)

1

cloned

No

YPO3069

16123246

-

putative exported protein

486

Virulence

Phase 1: October 2007

3C37

15%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP00180
(show subtarget assignments)

1

expressed

No

YPO0339

16120675

-

enhancing factor (viral)

856

Virulence

Phase 1: October 2007

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP00227
(show subtarget assignments)

1

expressed

No

YPO3249

16123408

-

putative amino acid hydrolase

430

Virulence

Phase 1: October 2007

3N5F

36%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00179
(show subtarget assignments)

1

cloned

No

YPO0277

16120616

-

putative transmembrane transport protein...

428

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Unknown function

General

IDP00229
(show subtarget assignments)

1

soluble

No

YPO0417

16120750

-

putative O-antigen biosynthesis protein

410

Virulence

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00230
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3444

16123592

-

putative acetyltransferase

167

Virulence

Phase 1: October 2007

2GE3

18%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00231
(show subtarget assignments)

1

soluble

No

YPO3479

16123625

-

putative protease

331

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00232
(show subtarget assignments)

1

cloned

No

YPO3480

16123626

-

conserved hypothetical protein

292

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00233
(show subtarget assignments)

1

cloned

No

YPO3676

16123819

-

putative phage-related protein

133

Virulence

Phase 1: October 2007

2VO9

25.6%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00178
(show subtarget assignments)

1

soluble

No

YPO3405

16123554

-

putative ABC transporter, integral membr...

256

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00252
(show subtarget assignments)

1

in_crystallization_trials

No

130516

St. Louis encephalitis virus Envelope pr...

407

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

2I69

70.5%

St. Louis

IDP00253
(show subtarget assignments)

1

in_crystallization_trials

No

YFVgp1

9627245

Yellow fever virus Envelope protein

399

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1P58

43.8%

Yellow fever

IDP00254
(show subtarget assignments)

1

in_pdb
3P54

Yes

13272205

Japanese encephalitis virus Envelope pro...

406

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

3P54

98.3%

Japanese encephalitis

IDP00255
(show subtarget assignments)

1

selected

No

NP_041725:276-677

9627243

CFA

Cell fusing agent virus Envelope protein...

402

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

3C5X

15.2%

Cell fusing

IDP00256
(show subtarget assignments)

1

expressed

No

RBVgp1

21397175

Rio Bravo bat virus Envelope protein

395

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1URZ

43.2%

Rio Bravo

IDP00257
(show subtarget assignments)

1

in_crystallization_trials

No

MODVgp1

20177456

Modoc virus Envelope protein

393

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1SVB

41%

Modoc virus

IDP00258
(show subtarget assignments)

1

in_crystallization_trials

No

MMLVgp1

22550316

Montana myotis leukoencephalitis Envelop...

395

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1URZ

43.6%

Montana myotis

IDP00259
(show subtarget assignments)

1

crystallized

No

CPXV018

30844336

CPXV229 CDS

OMCP protein Cowpox virus

171

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

Cowpox virus

IDP00260
(show subtarget assignments)

1

purified

No

AF380138

17529967

N3R

N3R [Monkeypox virus]

176

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

Monkeypox virus

IDP00263
(show subtarget assignments)

1

cloned

No

AF180817_1-114

7329982

N/A

Capsid protein (C)

114

Encapsidation of genomic RNA

Phase 3: June 2008

1R6R

60.5%

Dengue virus

Unclassified

N/A

IDP00264
(show subtarget assignments)

1

expressed

No

NP_056776_2244-2491

159024209

N/A

NS4B

248

possibly RNA replication

Phase 3: June 2008

Dengue virus

Transcription

N/A

IDP00265
(show subtarget assignments)

1

selected

No

AAA99437_775-1129

323469

N/A

NS1

355

Secreted from infected cells; stimulates protective immune responses (reason for...

Phase 3: June 2008

Dengue virus

host defense modulator

N/A

IDP00266
(show subtarget assignments)

1

cloned

No

AAX48017_114-279

61652905

N/A

Premembrane/Membrane protein (prM)

166

Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds

Phase 3: June 2008

3C5X

57.2%

Dengue virus

N/A

IDP00267
(show subtarget assignments)

1

cloned

No

AAX48017_4-113

61652905

N/A

Capsid protein (C)

111

Encapsidation of genomic RNA

Phase 3: June 2008

1R6R

60.4%

Dengue virus

Unclassified

N/A

IDP00268
(show subtarget assignments)

1

cloned

No

AAX48017_2488-3387

61652905

N/A

NS5 methyl transferase and RNA polymeras...

900

RNA-dependent RNA polymerase

Phase 3: June 2008

2J7U

54.7%

Dengue virus

Transcription

N/A

IDP00044
(show subtarget assignments)

1

in_pdb
3SLB
3SLF
3E4F
3IJW
3N0S
3KZL
3N0M

Yes

BA_2930

30257522

aacC7

aminoglycoside N3-acetyltransferase

265

Virulence

Phase 1: October 2007

3E4F

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00270
(show subtarget assignments)

1

cloned

No

AF180817_2245-2493

7329982

N/A

NS4B

249

possibly RNA replication

Phase 3: June 2008

Dengue virus

Transcription

N/A

IDP00022
(show subtarget assignments)

1

cloned

No

BA_5578

81714842

UDP-N-acetylglucosamine 1-carboxyvinyltr...

429

Drug Target Homolog

Phase 1: October 2007

3SG1

49.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00272
(show subtarget assignments)

1

in_pdb
3EGP
3IRC

No

AF180817_281-775

7329982

N/A

Envelope (E)

495

Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...

Phase 1: October 2007

3G7T

78.8%

Dengue virus

N/A

IDP00273
(show subtarget assignments)

1

selected

No

AF180817_1476-2094

7329982

N/A

NS3 RNA Helicase

619

Polyprotein processing, RNA replication

Phase 3: June 2008

2WZQ

76.4%

Dengue virus

Transcription

N/A

IDP00274
(show subtarget assignments)

1

selected

No

AF180817_2494-3392

7329982

N/A

NS5 methyl transferase and RNA polymeras...

830

RNA-dependent RNA polymerase

Phase 3: June 2008

2J7U

55.5%

Dengue virus

Transcription

N/A

IDP00275
(show subtarget assignments)

1

cloned

No

NP_056776_776-1127

159024209

N/A

NS1

352

Secreted from infected cells; stimulates protective immune responses (reason for...

Phase 3: June 2008

Dengue virus

host defense modulator

N/A

IDP00276
(show subtarget assignments)

1

soluble

No

AAA99437_115-280

323469

N/A

Premembrane/Membrane protein (prM)

166

Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds

Phase 3: June 2008

3C5X

56%

Dengue virus

N/A

IDP00011
(show subtarget assignments)

1

soluble

No

BA_2222

30256868

alcohol dehydrogenase, iron-containing

392

Drug Target Homolog

Phase 1: October 2007

3OWO

37.8%

Bacillus anthracis

Energy metabolism

Fermentation

IDP00005
(show subtarget assignments)

1

cloned

No

BA_0552

30254078

internalin, putative

1070

Virulence/Drug Target Homolog

Phase 1: October 2007

1M9S

13.5%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP00177
(show subtarget assignments)

1

purified

No

YPO3007

16123186

-

putative membrane protein

509

Virulence

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00176
(show subtarget assignments)

1

cloned

No

YPO4024

16124147

-

putative iron transport permease

335

Virulence

Phase 1: October 2007

2QI9

23.9%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00087
(show subtarget assignments)

1

expressed

No

NTL01ST2379

16420989

STM2449

putative acetyltransferase

178

Virulence

Phase 1: October 2007

2PDO

75.3%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00175
(show subtarget assignments)

1

soluble

No

YPO1471

16121746

-

putative ATPase subunit of ATP-dependent...

880

Virulence

Phase 1: October 2007

1QVR

36.9%

Yersinia pestis

IDP00174
(show subtarget assignments)

1

cloned

No

YPO1140

16121437

-

putative membrane protein

272

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Unknown function

General

IDP00086
(show subtarget assignments)

1

in_pdb
3DR6
3DR8

No

NT01ST1973

16420114

yncA

putative acyltransferase

171

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DR6

100%

Salmonella enterica

Transport and binding proteins

Other

IDP00043
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2629

30257246

acetyltransferase, CYSE/LACA/LPXA/NODL f...

210

Virulence

Phase 1: October 2007

4E8L

63.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00173
(show subtarget assignments)

1

cloned

No

YPO2922

16123109

-

putative membrane protein

486

Virulence

Phase 1: October 2007

3K4U

14.4%

Yersinia pestis

Unknown function

General

IDP00172
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2438

16122659

-

putative membrane-bound lytic murein tra...

220

Virulence

Phase 1: October 2007

2Y8P

42.7%

Yersinia pestis

Mobile and extrachromosomal element functions

Prophage functions

IDP00085
(show subtarget assignments)

1

in_crystallization_trials

No

NTL01ST1174

16419726

nagZ

putative glycosyl hydrolase

341

Virulence

Phase 1: October 2007

1TR9

55.4%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00171
(show subtarget assignments)

1

cloned

No

YPO0452

16120781

-

putative soluble lytic murein transglyco...

639

Similar to Essential SALTY

Phase 1: October 2007

1QSA

61.8%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00170
(show subtarget assignments)

1

soluble

No

VCA0865

15601620

hap

hemagglutinin/protease

609

Virulence

Phase 1: October 2007

1EZM

31.4%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00084
(show subtarget assignments)

1

expressed

No

NT01ST1435

16419673

yceI

putative secreted protein

191

Essential

Phase 1: October 2007

1Y0G

91.1%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00042
(show subtarget assignments)

1

soluble

No

BA_2507

30257134

bla1

beta-lactamase

309

Virulence

Phase 1: October 2007

3QHY

87.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00021
(show subtarget assignments)

1

in_pdb
3SG1

No

BA_5529

81714862

UDP-N-acetylglucosamine 1-carboxyvinyltr...

434

Drug Target Homolog

Phase 1: October 2007

3SG1

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00169
(show subtarget assignments)

1

expressed

No

VCA0218

15600987

No Data

thermolabile hemolysin

418

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00168
(show subtarget assignments)

1

cloned

No

VC2209

15642774

vibF

nonribosomal peptide synthetase VibF, au...

2413

Virulence

Phase 1: October 2007

2VSQ

10.2%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP00083
(show subtarget assignments)

1

in_crystallization_trials

No

NTL01ST0073

16418570

caiA

putative acyl-CoA dehydrogenase, carniti...

380

Essential

Phase 1: October 2007

2DVL

32.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP00166
(show subtarget assignments)

1

expressed

No

VC1450

15641461

rtxC

RTX toxin activating protein

153

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00041
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2409

30257040

chloramphenicol acetyltransferase

216

Virulence

Phase 1: October 2007

1QCA

41.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00020
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5315

47605857

UDP-N-acetylenolpyruvoylglucosamine redu...

305

Drug Target Homolog

Phase 1: October 2007

1HSK

59.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00165
(show subtarget assignments)

1

cloned

No

VC0844

15640861

acfA

accessory colonization factor AcfA

215

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00164
(show subtarget assignments)

1

soluble

No

VC0841

15640858

acfC

accessory colonization factor AcfC

256

Virulence

Phase 1: October 2007

3FIR

50%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00081
(show subtarget assignments)

1

in_crystallization_trials

No

NT01ST5473

16422973

ytfP

putative cytoplasmic protein

114

Essential

Phase 1: October 2007

1XHS

92.1%

Salmonella enterica

Unknown function

General

IDP00162
(show subtarget assignments)

1

soluble

No

VC0837

15640854

tcpF

toxin co-regulated pilus biosynthesis pr...

338

Virulence

Phase 1: October 2007

3OC5

93.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00080
(show subtarget assignments)

1

expressed

No

NT01ST5073

16422645

yneC

putative inner membrane protein

109

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3QMQ

70.6%

Salmonella enterica

Cell envelope

Other

IDP00040
(show subtarget assignments)

1

purified

No

BA_2042

46395770

Metallothiol transferase fosB 1 (Fosfomy...

138

Virulence

Phase 1: October 2007

3UH9

67.4%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00010
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2144

30256791

uroporphyrin-III C-methyltransferase, pu...

474

Drug Target Homolog

Phase 1: October 2007

1PJQ

24.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00002
(show subtarget assignments)

1

expressed

No

GBAA_pXO1_0079

47566400

-

surface layer protein, (pxo1-54)

404

Drug Target Homolog

Phase 1: October 2007

3PYW

14.4%

Bacillus anthracis

IDP00001
(show subtarget assignments)

1

cloned

No

BA_4599

30259099

aldehyde-alcohol dehydrogenase

867

Drug Target Homolog

Phase 1: October 2007

3MY7

24.5%

Bacillus anthracis

Energy metabolism

Fermentation

IDP00161
(show subtarget assignments)

1

soluble

No

VC0835

15640852

tcpT

toxin co-regulated pilus biosynthesis pr...

503

Virulence

Phase 1: October 2007

1P9R

23.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00160
(show subtarget assignments)

1

soluble

No

VC0834

15640851

tcpS

toxin co-regulated pilus biosynthesis pr...

152

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00079
(show subtarget assignments)

1

in_pdb
3DSA
3E7N

No

NT01ST4845

16422456

rbsD

D-ribose high-affinity transport system ...

139

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DSA

100%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00159
(show subtarget assignments)

1

purified

No

VC0831

15640848

tcpC

toxin co-regulated pilus biosynthesis ou...

489

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00158
(show subtarget assignments)

1

soluble

No

VC0830

15640847

tcpQ

toxin co-regulated pilus biosynthesis pr...

150

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00039
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1960

30256617

aminoglycoside 6-adenylyltransferase, pu...

290

Virulence

Phase 1: October 2007

2PBE

37.9%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00157
(show subtarget assignments)

1

soluble

No

VC0829

15640846

tcpB

toxin co-regulated pilus biosynthesis pr...

430

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00156
(show subtarget assignments)

1

purified

No

VC0407

15640434

mshF

MSHA biogenesis protein MshF

150

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00155
(show subtarget assignments)

1

in_crystallization_trials

No

VC0405

15640432

mshE

MSHA biogenesis protein MshE

575

Virulence

Phase 1: October 2007

1P9R

31.7%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00154
(show subtarget assignments)

1

crystallized

No

VC2448

15642444

pyrG

CTP synthase

545

Essential

Phase 1: October 2007

1S1M

79.5%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00076
(show subtarget assignments)

1

in_pdb
3NX4

No

NT01ST4228

16421936

yhdH

putative oxidoreductase

324

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3NX4

100%

Salmonella enterica

Cellular processes

Cell division

IDP00038
(show subtarget assignments)

1

in_pdb
3SR3
3GJZ
3T5M
3TYX
3U1B

No

BA_1949

30256607

microcin immunity protein MccF

333

Virulence

Phase 1: October 2007

3GJZ

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00019
(show subtarget assignments)

1

cloned

No

BA_4843

30259344

pykA-2

pyruvate kinase

585

Drug Target Homolog

Phase 1: October 2007

2E28

69.6%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00153
(show subtarget assignments)

1

expressed

No

VC0475

15640502

irgA

enterobactin receptor

652

Virulence

Phase 1: October 2007

2HDF

37.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

Targets