Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01173 (show subtarget assignments)	1	cloned	No	BA_1587	30255887		thermostable carboxypeptidase 1	505	Drug Target Function	Phase 2: March 2008	3HQ2	60.8%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01177 (show subtarget assignments)	1	cloned	No	BA_4515	30259020	sigA	RNA polymerase sigma-43 factor	373	Conserved Gene / Pathway	Phase 2: March 2008	1L9U	51.2%	Bacillus anthracis	Transcription	Transcription factors

IDP01180 (show subtarget assignments)	1	cloned	No	BA_0049	46396353		Ribose-phosphate pyrophosphokinase (RPPK...	317	Conserved Gene / Pathway	Phase 2: March 2008	1DKR	85.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01185 (show subtarget assignments)	1	cloned	No	BA_0280	30253775		glycosyl transferase, group 1 family pro...	443	Drug Target Function	Phase 2: March 2008	2JJM	13.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01190 (show subtarget assignments)	1	cloned	No	BA_0872	30254622		N-acetylmuramoyl-L-alanine amidase, fami...	348	Drug Target Function	Phase 2: March 2008	3HMB	25.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01200 (show subtarget assignments)	1	cloned	No	BA_1707	30255995		transglycosylase, SLT family	261	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01224 (show subtarget assignments)	1	cloned	No	BA_4054	30258561		sporulation specific penicillin-binding ...	638	Drug Target Function	Phase 2: March 2008	1PYY	26.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01239 (show subtarget assignments)	1	cloned	No	BA_5670	30260118		glycosyl transferase, group 1 family pro...	366	Drug Target Function	Phase 2: March 2008	2JJM	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01240 (show subtarget assignments)	1	cloned	No	BA_1069	30254800	pbpF	penicillin-binding protein 1	705	Drug Target Function	Phase 2: March 2008	2OLU	27.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01243 (show subtarget assignments)	1	cloned	No	BA_2345	30256982		penicillin-binding protein 1A	820	Drug Target Function	Phase 2: March 2008	2OLU	29.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01244 (show subtarget assignments)	1	cloned	No	BA_2504	30257132		penicillin-binding protein	588	Drug Target Function	Phase 2: March 2008	1MWR	23.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01245 (show subtarget assignments)	1	cloned	No	BA_2637	30257254		penicillin-binding protein	708	Drug Target Function	Phase 2: March 2008	2WAD	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01246 (show subtarget assignments)	1	cloned	No	BA_2648	30257265		penicillin-binding protein	712	Drug Target Function	Phase 2: March 2008	1QME	29.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01249 (show subtarget assignments)	1	cloned	No	BA_4055	30258562		penicillin-binding protein	716	Drug Target Function	Phase 2: March 2008	1QME	30.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01250 (show subtarget assignments)	1	cloned	No	BA_4497	30259003		penicillin-binding protein	706	Drug Target Function	Phase 2: March 2008	2WAF	33%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01251 (show subtarget assignments)	1	cloned	No	BA_4606	30259106		penicillin-binding protein	584	Drug Target Function	Phase 2: March 2008	3OC2	25.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01252 (show subtarget assignments)	1	cloned	No	BA_5623	30260075		penicillin-binding protein	683	Drug Target Function	Phase 2: March 2008	3UDF	28.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01253 (show subtarget assignments)	1	cloned	No	BA_2575	30257197		penicillin-binding protein, putative	481	Drug Target Function	Phase 2: March 2008	2QMI	20%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01314 (show subtarget assignments)	1	cloned	No	VCA0594	15601353		hemolysin	93	Virulence Associated Factor	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01315 (show subtarget assignments)	1	cloned	No	VC0942	15640958		hypothetical protein VC0942	117	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Other

IDP01323 (show subtarget assignments)	1	cloned	No	VC2633	15642628		fimbrial assembly protein PilN, putative...	196	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Surface structures

IDP01324 (show subtarget assignments)	1	cloned	No	VCA0910	15601664		tonB1 protein	249	Conserved Gene / Pathway	Phase 2: March 2008	2GRX	27.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01343 (show subtarget assignments)	1	cloned	No	VC2649	15642644	cysE	serine acetyltransferase	273	Drug Target Function	Phase 2: March 2008	1T3D	72.2%	Vibrio cholerae	Amino acid biosynthesis	Serine family

IDP01346 (show subtarget assignments)	1	cloned	No	VC1621	15641628		agglutination protein	445	Conserved Gene / Pathway	Phase 2: March 2008	2VDD	24.9%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01351 (show subtarget assignments)	1	cloned	No	VCA0387	15601150		toxin resistance protein	169	Conserved Gene / Pathway	Phase 2: March 2008	1YVO	31.4%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP01354 (show subtarget assignments)	1	cloned	No	VC0003	15640035	trmE	tRNA modification GTPase TrmE	464	Conserved Gene / Pathway	Phase 2: March 2008	3GEH	37.9%	Vibrio cholerae	Cellular processes	Detoxification

IDP01377 (show subtarget assignments)	1	cloned	No	VC0409	15640436		MSHA pilin protein MshA	178	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01378 (show subtarget assignments)	1	cloned	No	VC0410	15640437		MSHA pilin protein MshC	162	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01382 (show subtarget assignments)	1	cloned	No	VC0533	15640555		lipoprotein NlpD	311	Drug Target Function	Phase 2: March 2008	1QWY	24.1%	Vibrio cholerae	Cell envelope	Other

IDP01385 (show subtarget assignments)	1	cloned	No	VC0560	15640582		signal recognition particle protein	461	Drug Target Function	Phase 2: March 2008	2XXA	73.1%	Vibrio cholerae	Protein fate	Protein and peptide secretion and trafficking

IDP01387 (show subtarget assignments)	1	cloned	No	VC0566	15640588		protease DO	456	Drug Target Function	Phase 2: March 2008	2ZLE	57.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01391 (show subtarget assignments)	1	cloned	No	VC0633	15640653		outer membrane protein OmpU	350	Conserved Gene / Pathway	Phase 2: March 2008	3HW9	27.3%	Vibrio cholerae	Cell envelope	Other

IDP01398 (show subtarget assignments)	1	cloned	No	VC0762	15640781		outer membrane protein assembly complex ...	386	Conserved Gene / Pathway	Phase 2: March 2008	3P1L	43.3%	Vibrio cholerae	Cell envelope	Other

IDP01402 (show subtarget assignments)	1	cloned	No	VC0843	15640860		tagE protein	302	Drug Target Function	Phase 2: March 2008	3SLU	18.9%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01407 (show subtarget assignments)	1	cloned	No	VC0947	15640963		D-alanyl-D-alanine carboxypeptidase	391	Drug Target Function	Phase 2: March 2008	1NZO	52.2%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01420 (show subtarget assignments)	1	cloned	No	VC1496	15641505		carboxy-terminal protease	665	Drug Target Function	Phase 2: March 2008	1FC6	16.1%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01432 (show subtarget assignments)	1	cloned	No	VC1918	15641920		peptidyl-prolyl cis-trans isomerse D	619	Drug Target Function	Phase 2: March 2008	1M5Y	16%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01448 (show subtarget assignments)	1	cloned	No	VC2213	15642211		outer membrane protein OmpA	321	Conserved Gene / Pathway	Phase 2: March 2008	3NB3	34.7%	Vibrio cholerae	Cell envelope	Other

IDP01453 (show subtarget assignments)	1	cloned	No	VC2401	15642398	murG	N-acetylglucosaminyl transferase	354	Conserved Gene / Pathway	Phase 2: March 2008	1F0K	63.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01457 (show subtarget assignments)	1	cloned	No	VC2407	15642404		penicillin-binding protein 3	580	Drug Target Function	Phase 2: March 2008	3OC2	41.6%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01460 (show subtarget assignments)	1	cloned	No	VC2423	15642420		fimbrial protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1OQW	37.1%	Vibrio cholerae	Cell envelope	Surface structures

IDP01472 (show subtarget assignments)	1	cloned	No	VC2631	15642626		fimbrial assembly protein PilP, putative...	172	Conserved Gene / Pathway	Phase 2: March 2008	2LC4	16.3%	Vibrio cholerae	Cell envelope	Surface structures

IDP01480 (show subtarget assignments)	1	cloned	No	VCA0116	15600887		clpB protein	869	Drug Target Function	Phase 2: March 2008	1QVR	36.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01489 (show subtarget assignments)	1	cloned	No	VCA0591	15601350		peptide ABC transporter, periplasmic pep...	611	Conserved Gene / Pathway	Phase 2: March 2008	1ZTY	21.8%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01495 (show subtarget assignments)	1	cloned	No	VCA0803	15601558		serine protease, putative	330	Drug Target Function	Phase 2: March 2008	1BRU	24.2%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01499 (show subtarget assignments)	1	cloned	No	VCA0870	15601625	pbpG	D-alanyl-D-alanine endopeptidase	316	Drug Target Function	Phase 2: March 2008	3IT9	27.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01603 (show subtarget assignments)	1	cloned	No	STM1971	16765309	fliH	flagellar assembly protein H [Salmonella...	235	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP01606 (show subtarget assignments)	1	cloned	No	GBAA4968	47530266	gdH	glucose-1-dehydrogenase [Bacillus anthra...	261	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GEE	87.7%	Bacillus anthracis	Energy metabolism	Other

IDP01607 (show subtarget assignments)	1	cloned	No	FTT1608	56708628		ABC transporter, ATP-binding protein [Fr...	267	Conserved; Drug target functions	Phase 3: June 2008	3DHW	30%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01608 (show subtarget assignments)	1	cloned	No	CBU_1504	29542063	lepB-2	signal peptidase I [Coxiella burnetii RS...	256	Conserved; Drug target functions	Phase 3: June 2008	1B12	36.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP01612 (show subtarget assignments)	1	cloned	No	FTT1538c	56708570		hypothetical protein FTT1538c [Francisel...	327	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP01620 (show subtarget assignments)	1	cloned	No	FTT0687c	56707807	hslU	ATP-dependent protease ATP-binding subun...	455	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1DO0	64.6%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01621 (show subtarget assignments)	1	cloned	No	STM1984	16765321	yodD	putative cytoplasmic protein [Salmonella...	75	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01622 (show subtarget assignments)	1	cloned	No	STM4396	16767642	ytfB	putative cell envelope opacity-associate...	211	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01623 (show subtarget assignments)	1	cloned	No	GBAA5019	47530321	pckA	phosphoenolpyruvate carboxykinase [Bacil...	528	Conserved; Essential; Drug target functions	Phase 3: June 2008	1J3B	52.8%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01626 (show subtarget assignments)	1	cloned	No	GBAA5017	47530320	metK	S-adenosylmethionine synthetase [Bacillu...	399	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FUG	62.4%	Bacillus anthracis	Central intermediary metabolism	Other

IDP01627 (show subtarget assignments)	1	cloned	No	GBAA0530	50196914		glutamate synthase, large subunit, putat...	1478	Conserved; Drug target functions	Phase 3: June 2008	1EA0	29.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP01628 (show subtarget assignments)	1	cloned	No	CBU_1909	29542466	rpoH	RNA polymerase sigma-32 factor [Coxiella...	288	Conserved; Drug target functions	Phase 3: June 2008	3IYD	26.4%	Coxiella burnetii	Protein synthesis	Translation factors

IDP01629 (show subtarget assignments)	1	cloned	No	CBU_1903	29542460	ftsY	signal recognition particle-docking prot...	324	Conserved; Drug target functions	Phase 3: June 2008	2YHS	58%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP01632 (show subtarget assignments)	1	cloned	No	FTT1571c	56708597	lpxD	UDP-3-O-[3-hydroxymyristoyl] glucosamine...	337	Drug Target	Phase 3: June 2008	3EH0	45.1%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01636 (show subtarget assignments)	1	cloned	No	Cj1144c	15792469		hypothetical protein Cj1144c [Campylobac...	197	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01639 (show subtarget assignments)	1	cloned	No	GBAA4225	47529518		aminotransferase A [Bacillus anthracis s...	387	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1GD9	39.5%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01641 (show subtarget assignments)	1	cloned	No	CBU_0481	29541087	artP	amino acid ABC transporter, ATP-binding ...	250	Conserved; Drug target functions	Phase 3: June 2008	2OLJ	48%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01642 (show subtarget assignments)	1	cloned	No	Cj1150c	15792474	waaE	D,D-heptose 1-phosphate adenosyltransfer...	461	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	2AWD	15.6%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01644 (show subtarget assignments)	1	cloned	No	FTT0626	56707751	lon	DNA-binding, ATP-dependent protease La [...	774	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3M6A	37.7%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01648 (show subtarget assignments)	1	cloned	No	YPO2944	16123127		putative pili chaperone protein [Yersini...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	32.8%	Yersinia pestis	Cell envelope	Surface structures

IDP01651 (show subtarget assignments)	1	cloned	No	YPO2946	16123129	clpB5	Clp ATPase [Yersinia pestis CO92]	891	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	1QVR	35.5%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01653 (show subtarget assignments)	1	cloned	No	GBAA4538	47529835	dnaJ	chaperone protein dnaJ [Bacillus anthrac...	371	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3LZ8	34%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01657 (show subtarget assignments)	1	cloned	No	YPO3061	16123238	dapX	lipoprotein [Yersinia pestis CO92]	352	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3TGO	56.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP01669 (show subtarget assignments)	1	cloned	No	YPO3048	16123225		ABC transporter ATP-binding protein [Yer...	356	CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1Z47	36.8%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01670 (show subtarget assignments)	1	cloned	No	GBAA0156	47525414		hypothetical protein GBAA0156 [Bacillus ...	496	Conserved;	Phase 3: June 2008	2KQ1	6.7%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01671 (show subtarget assignments)	1	cloned	No	YPO3012	16123191	cysA	sulfate/thiosulfate transporter subunit ...	363	Conserved; CD; Drug target functions	Phase 3: June 2008	1Z47	39.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP01674 (show subtarget assignments)	1	cloned	No	lmo2543	16804581	prfA	peptide chain release factor 1 [Listeria...	358	Predicted virulence-Regulation	Phase 3: June 2008	1ZBT	63.7%	Listeria monocytogenes	Protein synthesis	Translation factors

IDP01676 (show subtarget assignments)	1	cloned	No	CBU_0869	29541462	alr	alanine racemase [Coxiella burnetii RSA ...	364	Conserved; Drug target functions	Phase 3: June 2008	2RJG	42.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01678 (show subtarget assignments)	1	cloned	No	GBAA5591	47530913		cardiolipin synthetase domain-containing...	397	Drug target motif; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01679 (show subtarget assignments)	1	cloned	No	FTT0738	56707853	yjeF	carbohydrate kinase family protein (YjeF...	514	Conserved; Drug target functions	Phase 3: June 2008	2AX3	28%	Francisella tularensis	Energy metabolism	Sugars

IDP01681 (show subtarget assignments)	1	cloned	No	GBAA4795	47530092		hypothetical protein GBAA4795 [Bacillus ...	572	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3AU2	37.1%	Bacillus anthracis	Unknown function	General

IDP01682 (show subtarget assignments)	1	cloned	No	GBAA5104	47530405		D-alanyl-D-alanine carboxypeptidase fami...	286	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01686 (show subtarget assignments)	1	cloned	No	Cj0804	15792142	pyrD	dihydroorotate dehydrogenase 2 [Campylob...	352	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1UUM	40.3%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01687 (show subtarget assignments)	1	cloned	No	Cj0740	15792089		hypothetical protein Cj0740 [Campylobact...	54	Predicted virulence-Adhesion of Campylobacter	Phase 3: June 2008			Campylobacter jejuni	Transport and binding proteins	Amino acids, peptides and amines

IDP01691 (show subtarget assignments)	1	cloned	No	CBU_1575	29542135	tolR	tolR protein [Coxiella burnetii RSA 493]...	147	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Transport and binding proteins	Other

IDP01692 (show subtarget assignments)	1	cloned	No	FTT1671	56708681	ribD	riboflavin biosynthesis protein ribD [Fr...	355	Conserved; Drug target functions	Phase 3: June 2008	2B3Z	37.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01696 (show subtarget assignments)	1	cloned	No	CBU_1767	29542324	feoA	ferrous iron transport protein A [Coxiel...	78	Conserved; Drug target functions	Phase 3: June 2008	2GCX	38.5%	Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP01697 (show subtarget assignments)	6	cloned	No	AAC68008	3328839	lpxB	Lipid A Disaccharide Synthase [Chlamydia...	607	LpxB is responsible for the formation of genus-specific lipolpolysaccharide epit...	Phase 3: June 2008			Chlamydia trachomatis	N/A	N/A

IDP01706 (show subtarget assignments)	1	cloned	No	STM1438	16764786	ydhL	putative oxidoreductase [Salmonella typh...	79	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01714 (show subtarget assignments)	1	cloned	No	Cj0528c	15791889	flgB	flagellar basal body rod protein FlgB [C...	143	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP01716 (show subtarget assignments)	1	cloned	No	Cj0687c	15792036	flgH	flagellar basal body L-ring protein [Cam...	232	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01717 (show subtarget assignments)	1	cloned	No	Cj0968	15792296		putative periplasmic protein [Campylobac...	80	Predicted virulence-Adhesion of Campylobacter; Possible Vaccine Candidate	Phase 3: June 2008			Campylobacter jejuni	Cellular processes	Other

IDP01718 (show subtarget assignments)	1	cloned	No	YPO3473	16123619		hypothetical protein YPO3473 [Yersinia p...	408	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3NFV	30.9%	Yersinia pestis	Cell envelope	Other

IDP01720 (show subtarget assignments)	1	cloned	No	Cj1128c	15792453	wlaD	general glycosylation pathway protein [C...	309	Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...	Phase 3: June 2008	3BCV	16.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00001 (show subtarget assignments)	1	cloned	No	BA_4599	30259099		aldehyde-alcohol dehydrogenase	867	Drug Target Homolog	Phase 1: October 2007	3MY7	24.5%	Bacillus anthracis	Energy metabolism	Fermentation

IDP01726 (show subtarget assignments)	1	cloned	No	GBAA5252	47530558		D-alanyl-D-alanine carboxypeptidase fami...	279	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	29.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01727 (show subtarget assignments)	1	cloned	No	FTT0769	56707883	secA	preprotein translocase subunit SecA [Fra...	906	Drug Target	Phase 3: June 2008	2FSF	53.4%	Francisella tularensis	Protein fate	Protein and peptide secretion and trafficking

IDP01729 (show subtarget assignments)	1	cloned	No	FTT0808	56707919	spoT	guanosine-3',5'-bis(diphosphate) 3'-pyro...	707	Conserved; Drug target functions	Phase 3: June 2008	1VJ7	23.6%	Francisella tularensis	Regulatory functionsAmino acid biosynthesis	OtherHistidine family

IDP01732 (show subtarget assignments)	1	cloned	No	STM1243	16764598		cold shock-like protein [Salmonella typh...	70	Conserved; Drug target functions	Phase 3: June 2008	2L15	48.6%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01733 (show subtarget assignments)	1	cloned	No	FTT0811c	56707922	murG	UDP-N-acetylglucosamine--N-acetylmuramyl...	371	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1F0K	39.4%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01734 (show subtarget assignments)	1	cloned	No	CBU_1094	29541668		efflux transporter, RND family, MFP subu...	380	Conserved; Drug target functions	Phase 3: June 2008	3FPP	23.9%	Coxiella burnetii	Transport and binding proteins	Other

IDP01738 (show subtarget assignments)	1	cloned	No	STM1484	16764829		putative protease [Salmonella typhimuriu...	273	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01740 (show subtarget assignments)	1	cloned	No	Cj1140	6968568	htrB	putative lipid A biosynthesis lauroyl ac...	295	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01741 (show subtarget assignments)	1	cloned	No	Cj1332	15792655	ptmA	flagellin modification protein A [Campyl...	256	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008	3QIV	30.2%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01173
(show subtarget assignments)

1

cloned

No

BA_1587

30255887

thermostable carboxypeptidase 1

505

Drug Target Function

Phase 2: March 2008

3HQ2

60.8%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01177
(show subtarget assignments)

1

cloned

No

BA_4515

30259020

sigA

RNA polymerase sigma-43 factor

373

Conserved Gene / Pathway

Phase 2: March 2008

1L9U

51.2%

Bacillus anthracis

Transcription

Transcription factors

IDP01180
(show subtarget assignments)

1

cloned

No

BA_0049

46396353

Ribose-phosphate pyrophosphokinase (RPPK...

317

Conserved Gene / Pathway

Phase 2: March 2008

1DKR

85.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01185
(show subtarget assignments)

1

cloned

No

BA_0280

30253775

glycosyl transferase, group 1 family pro...

443

Drug Target Function

Phase 2: March 2008

2JJM

13.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01190
(show subtarget assignments)

1

cloned

No

BA_0872

30254622

N-acetylmuramoyl-L-alanine amidase, fami...

348

Drug Target Function

Phase 2: March 2008

3HMB

25.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01200
(show subtarget assignments)

1

cloned

No

BA_1707

30255995

transglycosylase, SLT family

261

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01224
(show subtarget assignments)

1

cloned

No

BA_4054

30258561

sporulation specific penicillin-binding ...

638

Drug Target Function

Phase 2: March 2008

1PYY

26.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01239
(show subtarget assignments)

1

cloned

No

BA_5670

30260118

glycosyl transferase, group 1 family pro...

366

Drug Target Function

Phase 2: March 2008

2JJM

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01240
(show subtarget assignments)

1

cloned

No

BA_1069

30254800

pbpF

penicillin-binding protein 1

705

Drug Target Function

Phase 2: March 2008

2OLU

27.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01243
(show subtarget assignments)

1

cloned

No

BA_2345

30256982

penicillin-binding protein 1A

820

Drug Target Function

Phase 2: March 2008

2OLU

29.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01244
(show subtarget assignments)

1

cloned

No

BA_2504

30257132

penicillin-binding protein

588

Drug Target Function

Phase 2: March 2008

1MWR

23.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01245
(show subtarget assignments)

1

cloned

No

BA_2637

30257254

penicillin-binding protein

708

Drug Target Function

Phase 2: March 2008

2WAD

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01246
(show subtarget assignments)

1

cloned

No

BA_2648

30257265

penicillin-binding protein

712

Drug Target Function

Phase 2: March 2008

1QME

29.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01249
(show subtarget assignments)

1

cloned

No

BA_4055

30258562

penicillin-binding protein

716

Drug Target Function

Phase 2: March 2008

1QME

30.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01250
(show subtarget assignments)

1

cloned

No

BA_4497

30259003

penicillin-binding protein

706

Drug Target Function

Phase 2: March 2008

2WAF

33%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01251
(show subtarget assignments)

1

cloned

No

BA_4606

30259106

penicillin-binding protein

584

Drug Target Function

Phase 2: March 2008

3OC2

25.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01252
(show subtarget assignments)

1

cloned

No

BA_5623

30260075

penicillin-binding protein

683

Drug Target Function

Phase 2: March 2008

3UDF

28.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01253
(show subtarget assignments)

1

cloned

No

BA_2575

30257197

penicillin-binding protein, putative

481

Drug Target Function

Phase 2: March 2008

2QMI

20%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01314
(show subtarget assignments)

1

cloned

No

VCA0594

15601353

hemolysin

93

Virulence Associated Factor

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01315
(show subtarget assignments)

1

cloned

No

VC0942

15640958

hypothetical protein VC0942

117

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Other

IDP01323
(show subtarget assignments)

1

cloned

No

VC2633

15642628

fimbrial assembly protein PilN, putative...

196

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Surface structures

IDP01324
(show subtarget assignments)

1

cloned

No

VCA0910

15601664

tonB1 protein

249

Conserved Gene / Pathway

Phase 2: March 2008

2GRX

27.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01343
(show subtarget assignments)

1

cloned

No

VC2649

15642644

cysE

serine acetyltransferase

273

Drug Target Function

Phase 2: March 2008

1T3D

72.2%

Vibrio cholerae

Amino acid biosynthesis

Serine family

IDP01346
(show subtarget assignments)

1

cloned

No

VC1621

15641628

agglutination protein

445

Conserved Gene / Pathway

Phase 2: March 2008

2VDD

24.9%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01351
(show subtarget assignments)

1

cloned

No

VCA0387

15601150

toxin resistance protein

169

Conserved Gene / Pathway

Phase 2: March 2008

1YVO

31.4%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP01354
(show subtarget assignments)

1

cloned

No

VC0003

15640035

trmE

tRNA modification GTPase TrmE

464

Conserved Gene / Pathway

Phase 2: March 2008

3GEH

37.9%

Vibrio cholerae

Cellular processes

Detoxification

IDP01377
(show subtarget assignments)

1

cloned

No

VC0409

15640436

MSHA pilin protein MshA

178

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01378
(show subtarget assignments)

1

cloned

No

VC0410

15640437

MSHA pilin protein MshC

162

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01382
(show subtarget assignments)

1

cloned

No

VC0533

15640555

lipoprotein NlpD

311

Drug Target Function

Phase 2: March 2008

1QWY

24.1%

Vibrio cholerae

Cell envelope

Other

IDP01385
(show subtarget assignments)

1

cloned

No

VC0560

15640582

signal recognition particle protein

461

Drug Target Function

Phase 2: March 2008

2XXA

73.1%

Vibrio cholerae

Protein fate

Protein and peptide secretion and trafficking

IDP01387
(show subtarget assignments)

1

cloned

No

VC0566

15640588

protease DO

456

Drug Target Function

Phase 2: March 2008

2ZLE

57.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01391
(show subtarget assignments)

1

cloned

No

VC0633

15640653

outer membrane protein OmpU

350

Conserved Gene / Pathway

Phase 2: March 2008

3HW9

27.3%

Vibrio cholerae

Cell envelope

Other

IDP01398
(show subtarget assignments)

1

cloned

No

VC0762

15640781

outer membrane protein assembly complex ...

386

Conserved Gene / Pathway

Phase 2: March 2008

3P1L

43.3%

Vibrio cholerae

Cell envelope

Other

IDP01402
(show subtarget assignments)

1

cloned

No

VC0843

15640860

tagE protein

302

Drug Target Function

Phase 2: March 2008

3SLU

18.9%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01407
(show subtarget assignments)

1

cloned

No

VC0947

15640963

D-alanyl-D-alanine carboxypeptidase

391

Drug Target Function

Phase 2: March 2008

1NZO

52.2%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01420
(show subtarget assignments)

1

cloned

No

VC1496

15641505

carboxy-terminal protease

665

Drug Target Function

Phase 2: March 2008

1FC6

16.1%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01432
(show subtarget assignments)

1

cloned

No

VC1918

15641920

peptidyl-prolyl cis-trans isomerse D

619

Drug Target Function

Phase 2: March 2008

1M5Y

16%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01448
(show subtarget assignments)

1

cloned

No

VC2213

15642211

outer membrane protein OmpA

321

Conserved Gene / Pathway

Phase 2: March 2008

3NB3

34.7%

Vibrio cholerae

Cell envelope

Other

IDP01453
(show subtarget assignments)

1

cloned

No

VC2401

15642398

murG

N-acetylglucosaminyl transferase

354

Conserved Gene / Pathway

Phase 2: March 2008

1F0K

63.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01457
(show subtarget assignments)

1

cloned

No

VC2407

15642404

penicillin-binding protein 3

580

Drug Target Function

Phase 2: March 2008

3OC2

41.6%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01460
(show subtarget assignments)

1

cloned

No

VC2423

15642420

fimbrial protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1OQW

37.1%

Vibrio cholerae

Cell envelope

Surface structures

IDP01472
(show subtarget assignments)

1

cloned

No

VC2631

15642626

fimbrial assembly protein PilP, putative...

172

Conserved Gene / Pathway

Phase 2: March 2008

2LC4

16.3%

Vibrio cholerae

Cell envelope

Surface structures

IDP01480
(show subtarget assignments)

1

cloned

No

VCA0116

15600887

clpB protein

869

Drug Target Function

Phase 2: March 2008

1QVR

36.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01489
(show subtarget assignments)

1

cloned

No

VCA0591

15601350

peptide ABC transporter, periplasmic pep...

611

Conserved Gene / Pathway

Phase 2: March 2008

1ZTY

21.8%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01495
(show subtarget assignments)

1

cloned

No

VCA0803

15601558

serine protease, putative

330

Drug Target Function

Phase 2: March 2008

1BRU

24.2%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01499
(show subtarget assignments)

1

cloned

No

VCA0870

15601625

pbpG

D-alanyl-D-alanine endopeptidase

316

Drug Target Function

Phase 2: March 2008

3IT9

27.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01603
(show subtarget assignments)

1

cloned

No

STM1971

16765309

fliH

flagellar assembly protein H [Salmonella...

235

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP01606
(show subtarget assignments)

1

cloned

No

GBAA4968

47530266

gdH

glucose-1-dehydrogenase [Bacillus anthra...

261

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GEE

87.7%

Bacillus anthracis

Energy metabolism

Other

IDP01607
(show subtarget assignments)

1

cloned

No

FTT1608

56708628

ABC transporter, ATP-binding protein [Fr...

267

Conserved; Drug target functions

Phase 3: June 2008

3DHW

30%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01608
(show subtarget assignments)

1

cloned

No

CBU_1504

29542063

lepB-2

signal peptidase I [Coxiella burnetii RS...

256

Conserved; Drug target functions

Phase 3: June 2008

1B12

36.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP01612
(show subtarget assignments)

1

cloned

No

FTT1538c

56708570

hypothetical protein FTT1538c [Francisel...

327

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP01620
(show subtarget assignments)

1

cloned

No

FTT0687c

56707807

hslU

ATP-dependent protease ATP-binding subun...

455

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1DO0

64.6%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01621
(show subtarget assignments)

1

cloned

No

STM1984

16765321

yodD

putative cytoplasmic protein [Salmonella...

75

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01622
(show subtarget assignments)

1

cloned

No

STM4396

16767642

ytfB

putative cell envelope opacity-associate...

211

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01623
(show subtarget assignments)

1

cloned

No

GBAA5019

47530321

pckA

phosphoenolpyruvate carboxykinase [Bacil...

528

Conserved; Essential; Drug target functions

Phase 3: June 2008

1J3B

52.8%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01626
(show subtarget assignments)

1

cloned

No

GBAA5017

47530320

metK

S-adenosylmethionine synthetase [Bacillu...

399

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FUG

62.4%

Bacillus anthracis

Central intermediary metabolism

Other

IDP01627
(show subtarget assignments)

1

cloned

No

GBAA0530

50196914

glutamate synthase, large subunit, putat...

1478

Conserved; Drug target functions

Phase 3: June 2008

1EA0

29.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP01628
(show subtarget assignments)

1

cloned

No

CBU_1909

29542466

rpoH

RNA polymerase sigma-32 factor [Coxiella...

288

Conserved; Drug target functions

Phase 3: June 2008

3IYD

26.4%

Coxiella burnetii

Protein synthesis

Translation factors

IDP01629
(show subtarget assignments)

1

cloned

No

CBU_1903

29542460

ftsY

signal recognition particle-docking prot...

324

Conserved; Drug target functions

Phase 3: June 2008

2YHS

58%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP01632
(show subtarget assignments)

1

cloned

No

FTT1571c

56708597

lpxD

UDP-3-O-[3-hydroxymyristoyl] glucosamine...

337

Drug Target

Phase 3: June 2008

3EH0

45.1%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01636
(show subtarget assignments)

1

cloned

No

Cj1144c

15792469

hypothetical protein Cj1144c [Campylobac...

197

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01639
(show subtarget assignments)

1

cloned

No

GBAA4225

47529518

aminotransferase A [Bacillus anthracis s...

387

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1GD9

39.5%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01641
(show subtarget assignments)

1

cloned

No

CBU_0481

29541087

artP

amino acid ABC transporter, ATP-binding ...

250

Conserved; Drug target functions

Phase 3: June 2008

2OLJ

48%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01642
(show subtarget assignments)

1

cloned

No

Cj1150c

15792474

waaE

D,D-heptose 1-phosphate adenosyltransfer...

461

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

2AWD

15.6%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01644
(show subtarget assignments)

1

cloned

No

FTT0626

56707751

lon

DNA-binding, ATP-dependent protease La [...

774

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3M6A

37.7%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01648
(show subtarget assignments)

1

cloned

No

YPO2944

16123127

putative pili chaperone protein [Yersini...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

32.8%

Yersinia pestis

Cell envelope

Surface structures

IDP01651
(show subtarget assignments)

1

cloned

No

YPO2946

16123129

clpB5

Clp ATPase [Yersinia pestis CO92]

891

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

1QVR

35.5%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01653
(show subtarget assignments)

1

cloned

No

GBAA4538

47529835

dnaJ

chaperone protein dnaJ [Bacillus anthrac...

371

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3LZ8

34%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01657
(show subtarget assignments)

1

cloned

No

YPO3061

16123238

dapX

lipoprotein [Yersinia pestis CO92]

352

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3TGO

56.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP01669
(show subtarget assignments)

1

cloned

No

YPO3048

16123225

ABC transporter ATP-binding protein [Yer...

356

CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1Z47

36.8%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01670
(show subtarget assignments)

1

cloned

No

GBAA0156

47525414

hypothetical protein GBAA0156 [Bacillus ...

496

Conserved;

Phase 3: June 2008

2KQ1

6.7%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01671
(show subtarget assignments)

1

cloned

No

YPO3012

16123191

cysA

sulfate/thiosulfate transporter subunit ...

363

Conserved; CD; Drug target functions

Phase 3: June 2008

1Z47

39.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP01674
(show subtarget assignments)

1

cloned

No

lmo2543

16804581

prfA

peptide chain release factor 1 [Listeria...

358

Predicted virulence-Regulation

Phase 3: June 2008

1ZBT

63.7%

Listeria monocytogenes

Protein synthesis

Translation factors

IDP01676
(show subtarget assignments)

1

cloned

No

CBU_0869

29541462

alr

alanine racemase [Coxiella burnetii RSA ...

364

Conserved; Drug target functions

Phase 3: June 2008

2RJG

42.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01678
(show subtarget assignments)

1

cloned

No

GBAA5591

47530913

cardiolipin synthetase domain-containing...

397

Drug target motif; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01679
(show subtarget assignments)

1

cloned

No

FTT0738

56707853

yjeF

carbohydrate kinase family protein (YjeF...

514

Conserved; Drug target functions

Phase 3: June 2008

2AX3

28%

Francisella tularensis

Energy metabolism

Sugars

IDP01681
(show subtarget assignments)

1

cloned

No

GBAA4795

47530092

hypothetical protein GBAA4795 [Bacillus ...

572

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3AU2

37.1%

Bacillus anthracis

Unknown function

General

IDP01682
(show subtarget assignments)

1

cloned

No

GBAA5104

47530405

D-alanyl-D-alanine carboxypeptidase fami...

286

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01686
(show subtarget assignments)

1

cloned

No

Cj0804

15792142

pyrD

dihydroorotate dehydrogenase 2 [Campylob...

352

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1UUM

40.3%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01687
(show subtarget assignments)

1

cloned

No

Cj0740

15792089

hypothetical protein Cj0740 [Campylobact...

54

Predicted virulence-Adhesion of Campylobacter

Phase 3: June 2008

Campylobacter jejuni

Transport and binding proteins

Amino acids, peptides and amines

IDP01691
(show subtarget assignments)

1

cloned

No

CBU_1575

29542135

tolR

tolR protein [Coxiella burnetii RSA 493]...

147

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Transport and binding proteins

Other

IDP01692
(show subtarget assignments)

1

cloned

No

FTT1671

56708681

ribD

riboflavin biosynthesis protein ribD [Fr...

355

Conserved; Drug target functions

Phase 3: June 2008

2B3Z

37.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01696
(show subtarget assignments)

1

cloned

No

CBU_1767

29542324

feoA

ferrous iron transport protein A [Coxiel...

78

Conserved; Drug target functions

Phase 3: June 2008

2GCX

38.5%

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP01697
(show subtarget assignments)

6

cloned

No

AAC68008

3328839

lpxB

Lipid A Disaccharide Synthase [Chlamydia...

607

LpxB is responsible for the formation of genus-specific lipolpolysaccharide epit...

Phase 3: June 2008

Chlamydia trachomatis

N/A

IDP01706
(show subtarget assignments)

1

cloned

No

STM1438

16764786

ydhL

putative oxidoreductase [Salmonella typh...

79

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01714
(show subtarget assignments)

1

cloned

No

Cj0528c

15791889

flgB

flagellar basal body rod protein FlgB [C...

143

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP01716
(show subtarget assignments)

1

cloned

No

Cj0687c

15792036

flgH

flagellar basal body L-ring protein [Cam...

232

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01717
(show subtarget assignments)

1

cloned

No

Cj0968

15792296

putative periplasmic protein [Campylobac...

80

Predicted virulence-Adhesion of Campylobacter; Possible Vaccine Candidate

Phase 3: June 2008

Campylobacter jejuni

Cellular processes

Other

IDP01718
(show subtarget assignments)

1

cloned

No

YPO3473

16123619

hypothetical protein YPO3473 [Yersinia p...

408

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3NFV

30.9%

Yersinia pestis

Cell envelope

Other

IDP01720
(show subtarget assignments)

1

cloned

No

Cj1128c

15792453

wlaD

general glycosylation pathway protein [C...

309

Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...

Phase 3: June 2008

3BCV

16.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00001
(show subtarget assignments)

1

cloned

No

BA_4599

30259099

aldehyde-alcohol dehydrogenase

867

Drug Target Homolog

Phase 1: October 2007

3MY7

24.5%

Bacillus anthracis

Energy metabolism

Fermentation

IDP01726
(show subtarget assignments)

1

cloned

No

GBAA5252

47530558

D-alanyl-D-alanine carboxypeptidase fami...

279

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

29.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01727
(show subtarget assignments)

1

cloned

No

FTT0769

56707883

secA

preprotein translocase subunit SecA [Fra...

906

Drug Target

Phase 3: June 2008

2FSF

53.4%

Francisella tularensis

Protein fate

Protein and peptide secretion and trafficking

IDP01729
(show subtarget assignments)

1

cloned

No

FTT0808

56707919

spoT

guanosine-3',5'-bis(diphosphate) 3'-pyro...

707

Conserved; Drug target functions

Phase 3: June 2008

1VJ7

23.6%

Francisella tularensis

Regulatory functionsAmino acid biosynthesis

OtherHistidine family

IDP01732
(show subtarget assignments)

1

cloned

No

STM1243

16764598

cold shock-like protein [Salmonella typh...

70

Conserved; Drug target functions

Phase 3: June 2008

2L15

48.6%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01733
(show subtarget assignments)

1

cloned

No

FTT0811c

56707922

murG

UDP-N-acetylglucosamine--N-acetylmuramyl...

371

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1F0K

39.4%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01734
(show subtarget assignments)

1

cloned

No

CBU_1094

29541668

efflux transporter, RND family, MFP subu...

380

Conserved; Drug target functions

Phase 3: June 2008

3FPP

23.9%

Coxiella burnetii

Transport and binding proteins

Other

IDP01738
(show subtarget assignments)

1

cloned

No

STM1484

16764829

putative protease [Salmonella typhimuriu...

273

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01740
(show subtarget assignments)

1

cloned

No

Cj1140

6968568

htrB

putative lipid A biosynthesis lauroyl ac...

295

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01741
(show subtarget assignments)

1

cloned

No

Cj1332

15792655

ptmA

flagellin modification protein A [Campyl...

256

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

3QIV

30.2%

Campylobacter jejuni

Hypothetical proteins

Conserved

Targets