Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01426 (show subtarget assignments)	1	expressed	No	VC1680	15641684		peptide ABC transporter, periplasmic pep...	540	Conserved Gene / Pathway	Phase 2: March 2008	1DPP	35%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP04187 (show subtarget assignments)	1	expressed	No	VCA0723	15601479		3-hydroxy-3-methylglutaryl CoA reductase...	436	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1DQ8	35.5%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01103 (show subtarget assignments)	1	cloned	No	BA_1387	47605671		D-alanine--poly(phosphoribitol) ligase s...	79	Drug Target Function	Phase 2: March 2008	1DV5	45.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00620 (show subtarget assignments)	1	cloned	No	SACOL0937	57285812	dltC	D-alanine--poly(phosphoribitol) ligase s...	78	Conserved Gene / Pathway	Phase 2: March 2008	1DV5	41%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02623 (show subtarget assignments)	1	cloned	No	Cj1430c	15792748		putative nucleotide-sugar epimerase/dehy...	181	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1DZR	30.9%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90841 (show subtarget assignments)	8	soluble	No	S2223	30063489	rfbC	dTDP-6-deoxy-L-mannose-dehydrogenase [Sh...	181	Predicted Essential	Community Requests	1DZR	70.2%	Shigella flexneri

IDP01454 (show subtarget assignments)	1	purified	No	VC2403	161581989	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	444	Conserved Gene / Pathway	Phase 2: March 2008	1E0D	51.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00905 (show subtarget assignments)	0	work_stopped	No	STM0126	16763516	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	438	Essential Gene	Phase 2: March 2008	1E0D	92.2%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90636 (show subtarget assignments)	8	purified	No	Cj0432c	15791799	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	402	Predicted Essential	Community Requests	1E0D	27.6%	Campylobacter jejuni

IDP02376 (show subtarget assignments)	1	cloned	No	FTT0451	56707593	murD	UDP-N-acetylmuramoylalanine--D-glutamate...	416	Conserved; Drug target functions	Phase 3: June 2008	1E0D	31.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02024 (show subtarget assignments)	1	expressed	No	CBU_0131	29540751	murD	UDP-N-acetylmuramoylalanine--D-glutamate...	442	Conserved; Drug target functions	Phase 3: June 2008	1E0D	43%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90759 (show subtarget assignments)	8	expressed	No	YPO0553	16120881	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	438	Predicted Essential	Community Requests	1E0D	80.6%	Yersinia pestis

IDP00590 (show subtarget assignments)	1	cloned	No	YPO1078	16121379	mltD	predicted membrane-bound lytic murein tr...	475	Drug Target Function	Phase 2: March 2008	1E0G	7.8%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02363 (show subtarget assignments)	1	purified	No	FTT1366c	56708419	pyk	pyruvate kinase [Francisella tularensis ...	478	Conserved; Drug target functions	Phase 3: June 2008	1E0U	39.5%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP04033 (show subtarget assignments)	1	soluble	No	VC1950	15641952		biotin sulfoxide reductase [Vibrio chole...	815	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1E18	48.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02673 (show subtarget assignments)	1	expressed	No	STM4466	16767711		carbamate kinase [Salmonella typhimurium...	310	Conserved; Drug target functions	Phase 3: June 2008	1E19	45.5%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP90889 (show subtarget assignments)	8	cloned	No	VC0664	15640683	lysS	lysyl-tRNA synthetase [Vibrio cholerae O...	512	Predicted Essential	Community Requests	1E1O	58.8%	Vibrio cholerae

IDP90659 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0822	15792160	dfp	bifunctional phosphopantothenoylcysteine...	384	Predicted Essential	Community Requests	1E20	17.2%	Campylobacter jejuni

IDP92081 (show subtarget assignments)	8	selected	No	TGME49_106970	237845145		thymidylate kinase, putative [Toxoplasma...	273	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1E2D	35.2%	Toxoplasma gondii

IDP92553 (show subtarget assignments)	8	selected	No	VV1_2233	27361706	fadR	fatty acid metabolism transcriptional re...	279	potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...	Community Requests	1E2X	52%	Vibrio vulnificus

IDP02180 (show subtarget assignments)	1	cloned	No	Cj0299	15791667		putative periplasmic beta-lactamase [Cam...	257	Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...	Phase 3: June 2008	1E3U	34.6%	Campylobacter jejuni	Transport and binding proteins	Anions

IDP91787 (show subtarget assignments)	8	in_crystallization_trials	No	AAA24786	148325	vanC	D-alanine-D-alanine ligase-related prote...	343	drug resistance / D-Ala:D-Ser ligase	Community Requests	1E4E	39%	Enterococcus gallinarum

IDP91788 (show subtarget assignments)	8	in_crystallization_trials	No	ACM47287	222159814	vanD	D-Ala:D-Lac ligase VanD [Enterococcus fa...	343	drug resistance / D-Ala:D-Lac ligase	Community Requests	1E4E	67.1%	Enterococcus faecium

IDP91799 (show subtarget assignments)	8	selected	No	AAL27442	16612079	vanE	VanE [Enterococcus faecalis]	352	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1E4E	41.5%	Enterococcus faecalis

IDP91878 (show subtarget assignments)	8	selected	No	pVEF1_014	121633839	vanB	VanA protein [Enterococcus faecium]	343	drug resistance / The proteins play important roles in vancomycin resistance of Entercocci.	Community Requests	1E4E	98.8%	Enterococcus faecium

IDP91050 (show subtarget assignments)	8	in_crystallization_trials	No	EFE0001	1209531	vanB	D-Ala:D-Lac ligase [Enterococcus faecali...	342	drug resistance / D-lactate D-ala ligase; generates vancomycin resistant cell wall	Community Requests	1E4E	75.1%	Enterococcus faecalis

IDP02098 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0187	56707352	ftsA	cell division protein FtsA [Francisella ...	420	Conserved; Drug target functions	Phase 3: June 2008	1E4F	24%	Francisella tularensis	Cellular processes	Cell division

IDP00714 (show subtarget assignments)	1	cloned	No	SACOL1198	57285941	ftsA	cell division protein FtsA	470	Drug Target Function	Phase 2: March 2008	1E4F	18.3%	Staphylococcus aureus	Cellular processes	Cell division

IDP02788 (show subtarget assignments)	1	expressed	No	CBU_0140	29540760	ftsA	cell division protein FtsA [Coxiella bur...	410	Conserved; Drug target functions	Phase 3: June 2008	1E4F	22.9%	Coxiella burnetii	Cellular processes	Cell division

IDP91822 (show subtarget assignments)	8	soluble	No	b0755	1786970	gpmA	phosphoglyceromutase 1 [Escherichia coli...	250	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1E59	99.6%	Escherichia coli

IDP02032 (show subtarget assignments)	1	expressed	No	YPO0013	16120366	mobA	molybdopterin-guanine dinucleotide biosy...	213	Involved in virulence; Drug target functions	Phase 3: June 2008	1E5K	39.9%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP02559 (show subtarget assignments)	1	cloned	No	YPO3325	16123478	dmsA	anaerobic dimethyl sulfoxide reductase c...	816	Conserved; CD; Drug target functions	Phase 3: June 2008	1E60	28.7%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00615 (show subtarget assignments)	1	expressed	No	SACOL1160	57284445	sdhB	succinate dehydrogenase iron-sulfur subu...	271	Conserved Gene / Pathway	Phase 2: March 2008	1E7P	25.1%	Staphylococcus aureus	Energy metabolism	TCA cycle

IDP02026 (show subtarget assignments)	1	crystallized	No	CBU_0123	29540743	murE	UDP-N-acetylmuramoylalanyl-D-glutamate-2...	489	Conserved; Drug target functions	Phase 3: June 2008	1E8C	41.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00903 (show subtarget assignments)	0	work_stopped	No	STM0123	16763513	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	495	Essential Gene	Phase 2: March 2008	1E8C	91.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02223 (show subtarget assignments)	1	expressed	No	YPO0550	16120878	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	490	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1E8C	76.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01456 (show subtarget assignments)	1	purified	No	VC2406	15642403	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	512	Conserved Gene / Pathway	Phase 2: March 2008	1E8C	50.6%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01475 (show subtarget assignments)	1	in_crystallization_trials	No	VC2675	15642670		ATP-dependent protease peptidase subunit...	185	Conserved Gene / Pathway	Phase 2: March 2008	1E94	78.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00568 (show subtarget assignments)	0	work_stopped	No	YPO0106	16120453	hslV	ATP-dependent protease peptidase subunit...	174	Conserved Gene / Pathway	Phase 2: March 2008	1E94	90.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02473 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3967	47529257	hslU	ATP-dependent protease ATP-binding subun...	463	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1E94	50.8%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01053 (show subtarget assignments)	1	cloned	No	STM3330	16766625	gltB	glutamate synthase subunit alpha	1486	Conserved Gene / Pathway	Phase 2: March 2008	1EA0	45.2%	Salmonella enterica	Central intermediary metabolism	Other

IDP02086 (show subtarget assignments)	1	cloned	No	YPO3557	161486860	gltB	glutamate synthase subunit alpha [Yersin...	1538	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1EA0	45%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP01627 (show subtarget assignments)	1	cloned	No	GBAA0530	50196914		glutamate synthase, large subunit, putat...	1478	Conserved; Drug target functions	Phase 3: June 2008	1EA0	29.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP91677 (show subtarget assignments)	8	selected	No	FLUAVs7gp1	8486123	M1	matrix protein 1 [Influenza A virus (A/P...	252	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1EA3	65.1%	Influenza A

IDP02539 (show subtarget assignments)	1	cloned	No	YPO3200	16123361	malZ	maltodextrin glucosidase [Yersinia pesti...	609	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1EA9	33.5%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00740 (show subtarget assignments)	1	cloned	No	SACOL1105	57285891	pdhD	dihydrolipoamide dehydrogenase	468	Drug Target Function	Phase 2: March 2008	1EBD	70.9%	Staphylococcus aureus	Energy metabolism	Pyruvate dehydrogenase

IDP00585 (show subtarget assignments)	1	expressed	No	YPO0116	16120461	metL	bifunctional aspartate kinase II/homoser...	811	Virulence Associated Factor	Phase 2: March 2008	1EBF	15.5%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01441 (show subtarget assignments)	1	in_crystallization_trials	No	VC2023	15642025		3-oxoacyl-(acyl carrier protein) synthas...	316	Drug Target Function	Phase 2: March 2008	1EBL	72.6%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04657 (show subtarget assignments)	1	expressed	No	FTT1721c	56708727	purF	amidophosphoribosyltransferase [Francise...	496	conserved gene; putative drug target function;	Phase 4: April 2009	1ECB	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04475 (show subtarget assignments)	1	cloned	No	YPO2772	115348455	purF	amidophosphoribosyltransferase [Yersinia...	505	drug target; virulence factor; conserved gene; putative drug target function;...	Phase 4: April 2009	1ECB	86.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04344 (show subtarget assignments)	1	in_crystallization_trials	No	VC1004	15641019		amidophosphoribosyltransferase [Vibrio c...	504	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1ECB	76.1%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP91292 (show subtarget assignments)	8	soluble	No	SPA2526	56414632	pheA	bifunctional chorismate mutase/prephenat...	386	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ECM	24.9%	Salmonella enterica

IDP91304 (show subtarget assignments)	8	soluble	No	STM2667	16765982	pheA	chorismate mutase P/prephenate dehydrata...	386	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ECM	25.1%	Salmonella enterica

IDP91228 (show subtarget assignments)	8	soluble	No	NT04EC3200	26109368	pheA	P-protein [Escherichia coli CFT073]	386	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ECM	28.2%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP00142 (show subtarget assignments)	1	cloned	No	VC1456	15641467	ctxB	cholera enterotoxin, B subunit	124	Virulence	Phase 1: October 2007	1EEI	81.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01366 (show subtarget assignments)	1	soluble	No	VC0202	15640232		iron(III) ABC transporter, periplasmic i...	319	Conserved Gene / Pathway	Phase 2: March 2008	1EFD	25.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02412 (show subtarget assignments)	1	soluble	No	GBAA4760	47530059	etfB	electron transfer flavoprotein, beta sub...	257	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1EFP	38.2%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02709 (show subtarget assignments)	1	purified	No	GBAA3964	47529254	tsf	elongation factor Ts [Bacillus anthracis...	295	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1EFU	47.1%	Bacillus anthracis	Protein synthesis	Translation factors

IDP02682 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1502	29542061	era	GTP-binding protein Era [Coxiella burnet...	295	Conserved; Drug target functions	Phase 3: June 2008	1EGA	51.2%	Coxiella burnetii	Regulatory functions	RNA interactions

IDP00540 (show subtarget assignments)	1	purified	No	YPO2719	16122923	era	GTP-binding protein Era	303	Conserved Gene / Pathway	Phase 2: March 2008	1EGA	83.8%	Yersinia pestis	Cellular processes	Cell division

IDP02279 (show subtarget assignments)	1	crystallized	No	FTT1164c	56708234	era	GTP-binding protein Era [Francisella tul...	297	Drug Target	Phase 3: June 2008	1EGA	48.5%	Francisella tularensis	Cellular processesRegulatory functions	Cell divisionRNA interactions

IDP02529 (show subtarget assignments)	1	cloned	No	Cj0003	15791402	gyrB	DNA gyrase subunit B [Campylobacter jeju...	769	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	1EI1	27.2%	Campylobacter jejuni	Cell envelope	Other

IDP04572 (show subtarget assignments)	1	soluble	No	BAS0005	49183044		DNA gyrase subunit B [Bacillus anthracis...	640	Proposed to be essential proteins	Phase 4: April 2009	1EI1	34.4%	Bacillus anthracis

IDP02606 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0006	16802054	gyrB	DNA gyrase subunit B [Listeria monocytog...	646	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	1EI1	31.4%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP05229 (show subtarget assignments)	1	cloned	No	lmo1286	16803326	parE	DNA topoisomerase IV subunit B [Listeria...	655	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1EI1	29.8%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP90819 (show subtarget assignments)	8	purified	No	YPO4094	16124203	gyrB	DNA gyrase subunit B [Yersinia pestis CO...	804	Predicted Essential	Community Requests	1EI1	43.7%	Yersinia pestis

IDP90603 (show subtarget assignments)	8	selected	No	VC0015	15640047	gyrB	DNA gyrase subunit B [Vibrio cholerae O1...	805	Predicted Essential	Community Requests	1EI1	39.6%	Vibrio cholerae

IDP01028 (show subtarget assignments)	1	in_crystallization_trials	No	STM1707	16765051	pyrF	orotidine 5'-phosphate decarboxylase	245	Essential Gene	Phase 2: March 2008	1EIX	88.2%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04102 (show subtarget assignments)	1	cloned	No	YPO2227	218929324	pyrF	orotidine 5'-phosphate decarboxylase [Ye...	245	conserved gene; putative drug target function;	Phase 4: April 2009	1EIX	72.2%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP92129 (show subtarget assignments)	8	selected	No	TGME49_007990	237840609		ftsJ-like methyltransferase domain-conta...	981	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1EIZ	6.9%	Toxoplasma gondii

IDP00314 (show subtarget assignments)	1	expressed	No	CBU_0751	29654085	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	434	Drug Target Function	Phase 2: March 2008	1EJC	57.1%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00734 (show subtarget assignments)	1	purified	No	SACOL0841	57284303	pgm	phosphoglyceromutase	505	Drug Target Function	Phase 2: March 2008	1EJJ	62%	Staphylococcus aureus	Energy metabolism	Glycolysis/gluconeogenesis

IDP90562 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0434	15791801	pgm	phosphoglyceromutase [Campylobacter jeju...	492	Predicted Essential	Community Requests	1EJJ	44%	Campylobacter jejuni

IDP00913 (show subtarget assignments)	0	work_stopped	No	STM0219	16763609	frr	ribosome recycling factor	185	Conserved Gene / Pathway	Phase 2: March 2008	1EK8	94.1%	Salmonella enterica	Protein synthesis	Translation factors

IDP91364 (show subtarget assignments)	8	expressed	No	VV1_2716	27366006		Outer membrane protein [Vibrio vulnificu...	421	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1EK9	23.8%	Vibrio vulnificus

IDP00226 (show subtarget assignments)	1	soluble	No	YPO3938	16124066	glgP	glycogen phosphorylase	815	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 1: October 2007	1EM6	49.9%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04021 (show subtarget assignments)	1	expressed	No	BAS3695	49186694		30S ribosomal protein S16 [Bacillus anth...	90	Proposed to be essential proteins	Phase 4: April 2009	1EMW	42.2%	Bacillus anthracis

IDP04422 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4023	47529316	pyrD	dihydroorotate dehydrogenase 1B [Bacillu...	309	putative drug target function;	Phase 4: April 2009	1EP1	68%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04424 (show subtarget assignments)	1	purified	No	GBAA4024	47529317	pyrK	dihydroorotate dehydrogenase electron tr...	259	putative drug target function;	Phase 4: April 2009	1EP3	48.6%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP91208 (show subtarget assignments)	8	purified	No	BT_2186	29347596		3-phosphoshikimate 1-carboxyvinyltransfe...	410	potential drug target / Shikimate pathway enzyme	Community Requests	1EPS	36.2%	Bacteroides thetaiotaomicron

IDP90559 (show subtarget assignments)	8	cloned	No	VC0240	15640270	rfaD	ADP-L-glycero-D-mannoheptose-6-epimerase...	314	Predicted Essential	Community Requests	1EQ2	73.9%	Vibrio cholerae

IDP90552 (show subtarget assignments)	8	soluble	No	YPO0058	16120411	rfaD	ADP-L-glycero-D-mannoheptose-6-epimerase...	310	Predicted Essential	Community Requests	1EQ2	82.3%	Yersinia pestis

IDP90804 (show subtarget assignments)	8	soluble	No	VC0397	15640424		single-strand DNA-binding protein [Vibri...	177	Predicted Essential	Community Requests	1EQQ	75.1%	Vibrio cholerae

IDP90838 (show subtarget assignments)	8	cloned	No	YPO2053	16122292	aspS	aspartyl-tRNA synthetase [Yersinia pesti...	598	Predicted Essential	Community Requests	1EQR	80.8%	Yersinia pestis

IDP04615 (show subtarget assignments)	1	cloned	No	BAS4297	49187293		aspartyl-tRNA synthetase [Bacillus anthr...	591	Proposed to be essential proteins	Phase 4: April 2009	1EQR	52.7%	Bacillus anthracis

IDP05234 (show subtarget assignments)	1	cloned	No	lmo1519	16803559	aspS	aspartyl-tRNA synthetase [Listeria monoc...	591	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1EQR	52.2%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP02677 (show subtarget assignments)	1	cloned	No	FTT0879	56707983	sodC	superoxide dismuate (Cu-Zn) precusor [Fr...	185	Drug Target	Phase 3: June 2008	1EQW	50.3%	Francisella tularensis	Cellular processes	Detoxification

IDP91872 (show subtarget assignments)	8	selected	No	ACM47285	222159812	vanYD	D,D-carboxypeptidase VanYD [Enterococcus...	363	drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...	Community Requests	1ES4	24%	Enterococcus faecium

IDP00647 (show subtarget assignments)	1	selected	No	SACOL1657	57286179		enterotoxin type A, putative	234	Virulence Associated Factor	Phase 2: March 2008	1ESF	40.2%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP90625 (show subtarget assignments)	8	soluble	No	YPO3758	16123895	coaA	pantothenate kinase [Yersinia pestis CO9...	316	Predicted Essential	Community Requests	1ESM	85.8%	Yersinia pestis

IDP90876 (show subtarget assignments)	8	selected	No	VC0320	15640347		pantothenate kinase [Vibrio cholerae O1 ...	375	Predicted Essential	Community Requests	1ESM	53.3%	Vibrio cholerae

IDP00912 (show subtarget assignments)	1	soluble	No	STM0193	16763583	fhuD	iron-hydroxamate transporter substrate-b...	296	Conserved Gene / Pathway	Phase 2: March 2008	1ESZ	75%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP90852 (show subtarget assignments)	8	expressed	No	VC2018	15642020		4-amino-4-deoxychorismate lyase [Vibrio ...	277	Predicted Essential	Community Requests	1ET0	34.3%	Vibrio cholerae

IDP90908 (show subtarget assignments)	8	crystallized	No	STM1198	16764553	pabC	4-amino-4-deoxychorismate lyase [Salmone...	269	Predicted Essential	Community Requests	1ET0	69.9%	Salmonella enterica

IDP90912 (show subtarget assignments)	8	purified	No	YPO1603	16121871		4-amino-4-deoxychorismate lyase [Yersini...	268	Predicted Essential	Community Requests	1ET0	56%	Yersinia pestis

IDP04058 (show subtarget assignments)	1	soluble	No	CPF_0556	110800185		ABC transporter, solute-binding protein ...	461	drug target; putative drug target function;	Phase 4: April 2009	1EU8	18.9%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP05525 (show subtarget assignments)	1	soluble	No	CD2550	126700167		putative sugar transporter, substrate-bi...	430	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1EU8	25.8%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP02597 (show subtarget assignments)	1	expressed	No	YPO3472	16123618		putative sugar binding protein [Yersinia...	437	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1EU8	26.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05444 (show subtarget assignments)	1	soluble	No	lmo0768	16802810	-	hypothetical protein lmo0768 [Listeria m...	417	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1EU8	26.4%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP02504 (show subtarget assignments)	1	purified	No	FTT1578c	56708604	ung	uracil-DNA glycosylase [Francisella tula...	220	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1EUG	58.6%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP01426
(show subtarget assignments)

1

expressed

No

VC1680

15641684

peptide ABC transporter, periplasmic pep...

540

Conserved Gene / Pathway

Phase 2: March 2008

1DPP

35%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP04187
(show subtarget assignments)

1

expressed

No

VCA0723

15601479

3-hydroxy-3-methylglutaryl CoA reductase...

436

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1DQ8

35.5%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01103
(show subtarget assignments)

1

cloned

No

BA_1387

47605671

D-alanine--poly(phosphoribitol) ligase s...

79

Drug Target Function

Phase 2: March 2008

1DV5

45.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00620
(show subtarget assignments)

1

cloned

No

SACOL0937

57285812

dltC

D-alanine--poly(phosphoribitol) ligase s...

78

Conserved Gene / Pathway

Phase 2: March 2008

1DV5

41%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02623
(show subtarget assignments)

1

cloned

No

Cj1430c

15792748

putative nucleotide-sugar epimerase/dehy...

181

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1DZR

30.9%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90841
(show subtarget assignments)

8

soluble

No

S2223

30063489

rfbC

dTDP-6-deoxy-L-mannose-dehydrogenase [Sh...

181

Predicted Essential

Community Requests

1DZR

70.2%

Shigella flexneri

IDP01454
(show subtarget assignments)

1

purified

No

VC2403

161581989

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

444

Conserved Gene / Pathway

Phase 2: March 2008

1E0D

51.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00905
(show subtarget assignments)

0

work_stopped

No

STM0126

16763516

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

438

Essential Gene

Phase 2: March 2008

1E0D

92.2%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90636
(show subtarget assignments)

8

purified

No

Cj0432c

15791799

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

402

Predicted Essential

Community Requests

1E0D

27.6%

Campylobacter jejuni

IDP02376
(show subtarget assignments)

1

cloned

No

FTT0451

56707593

murD

UDP-N-acetylmuramoylalanine--D-glutamate...

416

Conserved; Drug target functions

Phase 3: June 2008

1E0D

31.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02024
(show subtarget assignments)

1

expressed

No

CBU_0131

29540751

murD

UDP-N-acetylmuramoylalanine--D-glutamate...

442

Conserved; Drug target functions

Phase 3: June 2008

1E0D

43%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90759
(show subtarget assignments)

8

expressed

No

YPO0553

16120881

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

438

Predicted Essential

Community Requests

1E0D

80.6%

Yersinia pestis

IDP00590
(show subtarget assignments)

1

cloned

No

YPO1078

16121379

mltD

predicted membrane-bound lytic murein tr...

475

Drug Target Function

Phase 2: March 2008

1E0G

7.8%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02363
(show subtarget assignments)

1

purified

No

FTT1366c

56708419

pyk

pyruvate kinase [Francisella tularensis ...

478

Conserved; Drug target functions

Phase 3: June 2008

1E0U

39.5%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP04033
(show subtarget assignments)

1

soluble

No

VC1950

15641952

biotin sulfoxide reductase [Vibrio chole...

815

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1E18

48.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02673
(show subtarget assignments)

1

expressed

No

STM4466

16767711

carbamate kinase [Salmonella typhimurium...

310

Conserved; Drug target functions

Phase 3: June 2008

1E19

45.5%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP90889
(show subtarget assignments)

8

cloned

No

VC0664

15640683

lysS

lysyl-tRNA synthetase [Vibrio cholerae O...

512

Predicted Essential

Community Requests

1E1O

58.8%

Vibrio cholerae

IDP90659
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0822

15792160

dfp

bifunctional phosphopantothenoylcysteine...

384

Predicted Essential

Community Requests

1E20

17.2%

Campylobacter jejuni

IDP92081
(show subtarget assignments)

8

selected

No

TGME49_106970

237845145

thymidylate kinase, putative [Toxoplasma...

273

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1E2D

35.2%

Toxoplasma gondii

IDP92553
(show subtarget assignments)

8

selected

No

VV1_2233

27361706

fadR

fatty acid metabolism transcriptional re...

279

potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...

Community Requests

1E2X

52%

Vibrio vulnificus

IDP02180
(show subtarget assignments)

1

cloned

No

Cj0299

15791667

putative periplasmic beta-lactamase [Cam...

257

Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...

Phase 3: June 2008

1E3U

34.6%

Campylobacter jejuni

Transport and binding proteins

Anions

IDP91787
(show subtarget assignments)

8

in_crystallization_trials

No

AAA24786

148325

vanC

D-alanine-D-alanine ligase-related prote...

343

drug resistance / D-Ala:D-Ser ligase

Community Requests

1E4E

39%

Enterococcus gallinarum

IDP91788
(show subtarget assignments)

8

in_crystallization_trials

No

ACM47287

222159814

vanD

D-Ala:D-Lac ligase VanD [Enterococcus fa...

343

drug resistance / D-Ala:D-Lac ligase

Community Requests

1E4E

67.1%

Enterococcus faecium

IDP91799
(show subtarget assignments)

8

selected

No

AAL27442

16612079

vanE

VanE [Enterococcus faecalis]

352

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1E4E

41.5%

Enterococcus faecalis

IDP91878
(show subtarget assignments)

8

selected

No

pVEF1_014

121633839

vanB

VanA protein [Enterococcus faecium]

343

drug resistance / The proteins play important roles in vancomycin resistance of Entercocci.

Community Requests

1E4E

98.8%

Enterococcus faecium

IDP91050
(show subtarget assignments)

8

in_crystallization_trials

No

EFE0001

1209531

vanB

D-Ala:D-Lac ligase [Enterococcus faecali...

342

drug resistance / D-lactate D-ala ligase; generates vancomycin resistant cell wall

Community Requests

1E4E

75.1%

Enterococcus faecalis

IDP02098
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0187

56707352

ftsA

cell division protein FtsA [Francisella ...

420

Conserved; Drug target functions

Phase 3: June 2008

1E4F

24%

Francisella tularensis

Cellular processes

Cell division

IDP00714
(show subtarget assignments)

1

cloned

No

SACOL1198

57285941

ftsA

cell division protein FtsA

470

Drug Target Function

Phase 2: March 2008

1E4F

18.3%

Staphylococcus aureus

Cellular processes

Cell division

IDP02788
(show subtarget assignments)

1

expressed

No

CBU_0140

29540760

ftsA

cell division protein FtsA [Coxiella bur...

410

Conserved; Drug target functions

Phase 3: June 2008

1E4F

22.9%

Coxiella burnetii

Cellular processes

Cell division

IDP91822
(show subtarget assignments)

8

soluble

No

b0755

1786970

gpmA

phosphoglyceromutase 1 [Escherichia coli...

250

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1E59

99.6%

Escherichia coli

IDP02032
(show subtarget assignments)

1

expressed

No

YPO0013

16120366

mobA

molybdopterin-guanine dinucleotide biosy...

213

Involved in virulence; Drug target functions

Phase 3: June 2008

1E5K

39.9%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP02559
(show subtarget assignments)

1

cloned

No

YPO3325

16123478

dmsA

anaerobic dimethyl sulfoxide reductase c...

816

Conserved; CD; Drug target functions

Phase 3: June 2008

1E60

28.7%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00615
(show subtarget assignments)

1

expressed

No

SACOL1160

57284445

sdhB

succinate dehydrogenase iron-sulfur subu...

271

Conserved Gene / Pathway

Phase 2: March 2008

1E7P

25.1%

Staphylococcus aureus

Energy metabolism

TCA cycle

IDP02026
(show subtarget assignments)

1

crystallized

No

CBU_0123

29540743

murE

UDP-N-acetylmuramoylalanyl-D-glutamate-2...

489

Conserved; Drug target functions

Phase 3: June 2008

1E8C

41.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00903
(show subtarget assignments)

0

work_stopped

No

STM0123

16763513

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

495

Essential Gene

Phase 2: March 2008

1E8C

91.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02223
(show subtarget assignments)

1

expressed

No

YPO0550

16120878

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

490

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1E8C

76.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01456
(show subtarget assignments)

1

purified

No

VC2406

15642403

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

512

Conserved Gene / Pathway

Phase 2: March 2008

1E8C

50.6%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01475
(show subtarget assignments)

1

in_crystallization_trials

No

VC2675

15642670

ATP-dependent protease peptidase subunit...

185

Conserved Gene / Pathway

Phase 2: March 2008

1E94

78.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00568
(show subtarget assignments)

0

work_stopped

No

YPO0106

16120453

hslV

ATP-dependent protease peptidase subunit...

174

Conserved Gene / Pathway

Phase 2: March 2008

1E94

90.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02473
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3967

47529257

hslU

ATP-dependent protease ATP-binding subun...

463

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1E94

50.8%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01053
(show subtarget assignments)

1

cloned

No

STM3330

16766625

gltB

glutamate synthase subunit alpha

1486

Conserved Gene / Pathway

Phase 2: March 2008

1EA0

45.2%

Salmonella enterica

Central intermediary metabolism

Other

IDP02086
(show subtarget assignments)

1

cloned

No

YPO3557

161486860

gltB

glutamate synthase subunit alpha [Yersin...

1538

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1EA0

45%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP01627
(show subtarget assignments)

1

cloned

No

GBAA0530

50196914

glutamate synthase, large subunit, putat...

1478

Conserved; Drug target functions

Phase 3: June 2008

1EA0

29.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP91677
(show subtarget assignments)

8

selected

No

FLUAVs7gp1

8486123

M1

matrix protein 1 [Influenza A virus (A/P...

252

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1EA3

65.1%

Influenza A

IDP02539
(show subtarget assignments)

1

cloned

No

YPO3200

16123361

malZ

maltodextrin glucosidase [Yersinia pesti...

609

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1EA9

33.5%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00740
(show subtarget assignments)

1

cloned

No

SACOL1105

57285891

pdhD

dihydrolipoamide dehydrogenase

468

Drug Target Function

Phase 2: March 2008

1EBD

70.9%

Staphylococcus aureus

Energy metabolism

Pyruvate dehydrogenase

IDP00585
(show subtarget assignments)

1

expressed

No

YPO0116

16120461

metL

bifunctional aspartate kinase II/homoser...

811

Virulence Associated Factor

Phase 2: March 2008

1EBF

15.5%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01441
(show subtarget assignments)

1

in_crystallization_trials

No

VC2023

15642025

3-oxoacyl-(acyl carrier protein) synthas...

316

Drug Target Function

Phase 2: March 2008

1EBL

72.6%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04657
(show subtarget assignments)

1

expressed

No

FTT1721c

56708727

purF

amidophosphoribosyltransferase [Francise...

496

conserved gene; putative drug target function;

Phase 4: April 2009

1ECB

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04475
(show subtarget assignments)

1

cloned

No

YPO2772

115348455

purF

amidophosphoribosyltransferase [Yersinia...

505

drug target; virulence factor; conserved gene; putative drug target function;...

Phase 4: April 2009

1ECB

86.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04344
(show subtarget assignments)

1

in_crystallization_trials

No

VC1004

15641019

amidophosphoribosyltransferase [Vibrio c...

504

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1ECB

76.1%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP91292
(show subtarget assignments)

8

soluble

No

SPA2526

56414632

pheA

bifunctional chorismate mutase/prephenat...

386

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ECM

24.9%

Salmonella enterica

IDP91304
(show subtarget assignments)

8

soluble

No

STM2667

16765982

pheA

chorismate mutase P/prephenate dehydrata...

386

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ECM

25.1%

Salmonella enterica

IDP91228
(show subtarget assignments)

8

soluble

No

NT04EC3200

26109368

pheA

P-protein [Escherichia coli CFT073]

386

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ECM

28.2%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP00142
(show subtarget assignments)

1

cloned

No

VC1456

15641467

ctxB

cholera enterotoxin, B subunit

124

Virulence

Phase 1: October 2007

1EEI

81.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01366
(show subtarget assignments)

1

soluble

No

VC0202

15640232

iron(III) ABC transporter, periplasmic i...

319

Conserved Gene / Pathway

Phase 2: March 2008

1EFD

25.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02412
(show subtarget assignments)

1

soluble

No

GBAA4760

47530059

etfB

electron transfer flavoprotein, beta sub...

257

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1EFP

38.2%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02709
(show subtarget assignments)

1

purified

No

GBAA3964

47529254

tsf

elongation factor Ts [Bacillus anthracis...

295

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1EFU

47.1%

Bacillus anthracis

Protein synthesis

Translation factors

IDP02682
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1502

29542061

era

GTP-binding protein Era [Coxiella burnet...

295

Conserved; Drug target functions

Phase 3: June 2008

1EGA

51.2%

Coxiella burnetii

Regulatory functions

RNA interactions

IDP00540
(show subtarget assignments)

1

purified

No

YPO2719

16122923

era

GTP-binding protein Era

303

Conserved Gene / Pathway

Phase 2: March 2008

1EGA

83.8%

Yersinia pestis

Cellular processes

Cell division

IDP02279
(show subtarget assignments)

1

crystallized

No

FTT1164c

56708234

era

GTP-binding protein Era [Francisella tul...

297

Drug Target

Phase 3: June 2008

1EGA

48.5%

Francisella tularensis

Cellular processesRegulatory functions

Cell divisionRNA interactions

IDP02529
(show subtarget assignments)

1

cloned

No

Cj0003

15791402

gyrB

DNA gyrase subunit B [Campylobacter jeju...

769

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

1EI1

27.2%

Campylobacter jejuni

Cell envelope

Other

IDP04572
(show subtarget assignments)

1

soluble

No

BAS0005

49183044

DNA gyrase subunit B [Bacillus anthracis...

640

Proposed to be essential proteins

Phase 4: April 2009

1EI1

34.4%

Bacillus anthracis

IDP02606
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0006

16802054

gyrB

DNA gyrase subunit B [Listeria monocytog...

646

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

1EI1

31.4%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP05229
(show subtarget assignments)

1

cloned

No

lmo1286

16803326

parE

DNA topoisomerase IV subunit B [Listeria...

655

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1EI1

29.8%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP90819
(show subtarget assignments)

8

purified

No

YPO4094

16124203

gyrB

DNA gyrase subunit B [Yersinia pestis CO...

804

Predicted Essential

Community Requests

1EI1

43.7%

Yersinia pestis

IDP90603
(show subtarget assignments)

8

selected

No

VC0015

15640047

gyrB

DNA gyrase subunit B [Vibrio cholerae O1...

805

Predicted Essential

Community Requests

1EI1

39.6%

Vibrio cholerae

IDP01028
(show subtarget assignments)

1

in_crystallization_trials

No

STM1707

16765051

pyrF

orotidine 5'-phosphate decarboxylase

245

Essential Gene

Phase 2: March 2008

1EIX

88.2%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04102
(show subtarget assignments)

1

cloned

No

YPO2227

218929324

pyrF

orotidine 5'-phosphate decarboxylase [Ye...

245

conserved gene; putative drug target function;

Phase 4: April 2009

1EIX

72.2%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP92129
(show subtarget assignments)

8

selected

No

TGME49_007990

237840609

ftsJ-like methyltransferase domain-conta...

981

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1EIZ

6.9%

Toxoplasma gondii

IDP00314
(show subtarget assignments)

1

expressed

No

CBU_0751

29654085

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

434

Drug Target Function

Phase 2: March 2008

1EJC

57.1%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00734
(show subtarget assignments)

1

purified

No

SACOL0841

57284303

pgm

phosphoglyceromutase

505

Drug Target Function

Phase 2: March 2008

1EJJ

62%

Staphylococcus aureus

Energy metabolism

Glycolysis/gluconeogenesis

IDP90562
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0434

15791801

pgm

phosphoglyceromutase [Campylobacter jeju...

492

Predicted Essential

Community Requests

1EJJ

44%

Campylobacter jejuni

IDP00913
(show subtarget assignments)

0

work_stopped

No

STM0219

16763609

frr

ribosome recycling factor

185

Conserved Gene / Pathway

Phase 2: March 2008

1EK8

94.1%

Salmonella enterica

Protein synthesis

Translation factors

IDP91364
(show subtarget assignments)

8

expressed

No

VV1_2716

27366006

Outer membrane protein [Vibrio vulnificu...

421

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1EK9

23.8%

Vibrio vulnificus

IDP00226
(show subtarget assignments)

1

soluble

No

YPO3938

16124066

glgP

glycogen phosphorylase

815

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 1: October 2007

1EM6

49.9%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04021
(show subtarget assignments)

1

expressed

No

BAS3695

49186694

30S ribosomal protein S16 [Bacillus anth...

90

Proposed to be essential proteins

Phase 4: April 2009

1EMW

42.2%

Bacillus anthracis

IDP04422
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4023

47529316

pyrD

dihydroorotate dehydrogenase 1B [Bacillu...

309

putative drug target function;

Phase 4: April 2009

1EP1

68%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04424
(show subtarget assignments)

1

purified

No

GBAA4024

47529317

pyrK

dihydroorotate dehydrogenase electron tr...

259

putative drug target function;

Phase 4: April 2009

1EP3

48.6%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP91208
(show subtarget assignments)

8

purified

No

BT_2186

29347596

3-phosphoshikimate 1-carboxyvinyltransfe...

410

potential drug target / Shikimate pathway enzyme

Community Requests

1EPS

36.2%

Bacteroides thetaiotaomicron

IDP90559
(show subtarget assignments)

8

cloned

No

VC0240

15640270

rfaD

ADP-L-glycero-D-mannoheptose-6-epimerase...

314

Predicted Essential

Community Requests

1EQ2

73.9%

Vibrio cholerae

IDP90552
(show subtarget assignments)

8

soluble

No

YPO0058

16120411

rfaD

ADP-L-glycero-D-mannoheptose-6-epimerase...

310

Predicted Essential

Community Requests

1EQ2

82.3%

Yersinia pestis

IDP90804
(show subtarget assignments)

8

soluble

No

VC0397

15640424

single-strand DNA-binding protein [Vibri...

177

Predicted Essential

Community Requests

1EQQ

75.1%

Vibrio cholerae

IDP90838
(show subtarget assignments)

8

cloned

No

YPO2053

16122292

aspS

aspartyl-tRNA synthetase [Yersinia pesti...

598

Predicted Essential

Community Requests

1EQR

80.8%

Yersinia pestis

IDP04615
(show subtarget assignments)

1

cloned

No

BAS4297

49187293

aspartyl-tRNA synthetase [Bacillus anthr...

591

Proposed to be essential proteins

Phase 4: April 2009

1EQR

52.7%

Bacillus anthracis

IDP05234
(show subtarget assignments)

1

cloned

No

lmo1519

16803559

aspS

aspartyl-tRNA synthetase [Listeria monoc...

591

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1EQR

52.2%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP02677
(show subtarget assignments)

1

cloned

No

FTT0879

56707983

sodC

superoxide dismuate (Cu-Zn) precusor [Fr...

185

Drug Target

Phase 3: June 2008

1EQW

50.3%

Francisella tularensis

Cellular processes

Detoxification

IDP91872
(show subtarget assignments)

8

selected

No

ACM47285

222159812

vanYD

D,D-carboxypeptidase VanYD [Enterococcus...

363

drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...

Community Requests

1ES4

24%

Enterococcus faecium

IDP00647
(show subtarget assignments)

1

selected

No

SACOL1657

57286179

enterotoxin type A, putative

234

Virulence Associated Factor

Phase 2: March 2008

1ESF

40.2%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP90625
(show subtarget assignments)

8

soluble

No

YPO3758

16123895

coaA

pantothenate kinase [Yersinia pestis CO9...

316

Predicted Essential

Community Requests

1ESM

85.8%

Yersinia pestis

IDP90876
(show subtarget assignments)

8

selected

No

VC0320

15640347

pantothenate kinase [Vibrio cholerae O1 ...

375

Predicted Essential

Community Requests

1ESM

53.3%

Vibrio cholerae

IDP00912
(show subtarget assignments)

1

soluble

No

STM0193

16763583

fhuD

iron-hydroxamate transporter substrate-b...

296

Conserved Gene / Pathway

Phase 2: March 2008

1ESZ

75%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP90852
(show subtarget assignments)

8

expressed

No

VC2018

15642020

4-amino-4-deoxychorismate lyase [Vibrio ...

277

Predicted Essential

Community Requests

1ET0

34.3%

Vibrio cholerae

IDP90908
(show subtarget assignments)

8

crystallized

No

STM1198

16764553

pabC

4-amino-4-deoxychorismate lyase [Salmone...

269

Predicted Essential

Community Requests

1ET0

69.9%

Salmonella enterica

IDP90912
(show subtarget assignments)

8

purified

No

YPO1603

16121871

4-amino-4-deoxychorismate lyase [Yersini...

268

Predicted Essential

Community Requests

1ET0

56%

Yersinia pestis

IDP04058
(show subtarget assignments)

1

soluble

No

CPF_0556

110800185

ABC transporter, solute-binding protein ...

461

drug target; putative drug target function;

Phase 4: April 2009

1EU8

18.9%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP05525
(show subtarget assignments)

1

soluble

No

CD2550

126700167

putative sugar transporter, substrate-bi...

430

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1EU8

25.8%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP02597
(show subtarget assignments)

1

expressed

No

YPO3472

16123618

putative sugar binding protein [Yersinia...

437

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1EU8

26.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05444
(show subtarget assignments)

1

soluble

No

lmo0768

16802810

-

hypothetical protein lmo0768 [Listeria m...

417

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1EU8

26.4%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP02504
(show subtarget assignments)

1

purified

No

FTT1578c

56708604

ung

uracil-DNA glycosylase [Francisella tula...

220

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1EUG

58.6%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair