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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 4 of 60, showing 100 records out of 5973 total, starting on record 301
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP02338
(
show subtarget assignments
)
1
cloned
No
GBAA1456
47526731
sensor histidine kinase [Bacillus anthra...
351
Conserved; Drug target functions
Phase 3: June 2008
3EHH
14.2%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP90967
(
show subtarget assignments
)
8
cloned
No
UTI89_C2819
122422922
Hypothetical protein yfgF
747
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3HVB
14.2%
Escherichia coli
IDP01247
(
show subtarget assignments
)
1
soluble
No
BA_3214
30257780
penicillin-binding protein, putative
691
Drug Target Function
Phase 2: March 2008
2QMI
14.2%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP91902
(
show subtarget assignments
)
8
selected
No
SpneCM_010100007650
298255460
phosphate ABC transporter, permease prot...
294
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3DHW
14.3%
Streptococcus pneumoniae
IDP04385
(
show subtarget assignments
)
1
expressed
No
YPO2689
115348373
kdpD
two-component regulatory protein sensor ...
908
conserved gene; putative drug target function;
Phase 4: April 2009
2R8R
14.3%
Yersinia pestis
Regulatory functions
Other
IDP05304
(
show subtarget assignments
)
1
cloned
No
Z1313
12514147
helD
DNA helicase IV [Escherichia coli O157:H...
715
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2IS1
14.3%
Escherichia coli
DNA metabolism: DNA replication, recombination, and repair
IDP02272
(
show subtarget assignments
)
1
cloned
No
GBAA2183
47527475
neutral metalloprotease, putative [Bacil...
503
Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...
Phase 3: June 2008
1BQB
14.3%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP02273
(
show subtarget assignments
)
1
expressed
No
GBAA3714
47528998
hypothetical protein GBAA3714 [Bacillus ...
315
Conserved; Essential;
Phase 3: June 2008
3CCF
14.3%
Bacillus anthracis
Hypothetical proteins
Domain
IDP04272
(
show subtarget assignments
)
1
expressed
No
GBAA3899
47529188
lantibiotic biosynthesis sensor histidin...
453
putative drug target function;
Phase 4: April 2009
2C2A
14.3%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP90209
(
show subtarget assignments
)
8
expressed
No
MYXV_gp144
9633776
m140R
m140R
553
kelch motif, similar to VACV-Cop:A55R
Community Requests
1U6D
14.3%
Myxoma virus
unknown, conserved protein
0
IDP91914
(
show subtarget assignments
)
8
selected
No
SpneCMD_010100003195
298229663
choline binding protein D [Streptococcus...
448
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2V04
14.3%
Streptococcus pneumoniae
IDP00775
(
show subtarget assignments
)
1
purified
No
SACOL0611
57285626
glycosyl transferase, group 1 family pro...
490
Conserved Gene / Pathway
Phase 2: March 2008
2JJM
14.3%
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP00452
(
show subtarget assignments
)
1
purified
No
YPO2245
16122473
electron transport complex protein RnfB ...
188
Conserved Gene / Pathway
Phase 2: March 2008
1GT8
14.4%
Yersinia pestis
Unknown function
General
IDP91614
(
show subtarget assignments
)
8
purified
No
BAB36909
13362957
ECs3486
hypothetical protein [Escherichia coli O...
216
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
14.4%
Escherichia coli
IDP00173
(
show subtarget assignments
)
1
cloned
No
YPO2922
16123109
-
putative membrane protein
486
Virulence
Phase 1: October 2007
3K4U
14.4%
Yersinia pestis
Unknown function
General
IDP05639
(
show subtarget assignments
)
1
soluble
No
CD2713
126700327
cell surface protein [Clostridium diffic...
653
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2V04
14.4%
Clostridium difficile
Cell envelope: Other
IDP05655
(
show subtarget assignments
)
1
soluble
No
lmo0159
16802207
-
peptidoglycan binding protein [Listeria ...
793
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3KPT
14.4%
Listeria monocytogenes
Cell envelope: Other
IDP04387
(
show subtarget assignments
)
1
expressed
No
YPO3606
218930616
putative Rhs accessory genetic element [...
800
virulence factor; putative drug target function;
Phase 4: April 2009
2P5Z
14.4%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP90184
(
show subtarget assignments
)
8
expressed
No
AAM13486.1
20153025
CPXV039 CDS
CPXV039 protein
473
ankyrin repeat protein
Community Requests
1N11
14.4%
Cowpox virus
conserved hypothetical proteins
0
IDP00002
(
show subtarget assignments
)
1
expressed
No
GBAA_pXO1_0079
47566400
-
surface layer protein, (pxo1-54)
404
Drug Target Homolog
Phase 1: October 2007
3PYW
14.4%
Bacillus anthracis
IDP04164
(
show subtarget assignments
)
1
cloned
No
VC1445
15641456
sensor histidine kinase/response regulat...
572
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
14.5%
Vibrio cholerae
Regulatory functions
Other
IDP05549
(
show subtarget assignments
)
1
soluble
No
lmo0549
16802592
-
hypothetical protein lmo0549 [Listeria m...
673
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1M9S
14.6%
Listeria monocytogenes
Transport and binding proteins: Amino acids, peptides and amines
IDP02583
(
show subtarget assignments
)
1
soluble
No
GBAA5249
47530554
3-hydroxyacyl-CoA dehydrogenase/enoyl-Co...
793
Conserved; Drug target functions
Phase 3: June 2008
1WDK
14.6%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Degradation
IDP91740
(
show subtarget assignments
)
8
selected
No
Q6V4L1_STRPY
0
398
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2XNX
14.6%
Streptococcus pyogenes
IDP01859
(
show subtarget assignments
)
1
cloned
No
lmo2558
16804596
ami
autolysin, amidase [Listeria monocytogen...
917
Known virulence-adherence; Possible Vaccine Candidate; PMID:11251838
Phase 3: June 2008
1M9S
14.7%
Listeria monocytogenes
Transport and binding proteins
Unknown substrate
IDP04710
(
show subtarget assignments
)
1
selected
No
YPO0510
115346319
hypothetical protein [Yersinia pestis CO...
367
virulence factor; conserved gene;
Phase 4: April 2009
2XT2
14.7%
Yersinia pestis
Unknown function
General
IDP04277
(
show subtarget assignments
)
1
cloned
No
BAS3960
49186958
PTS system, glucose-specific IIABC compo...
687
Proposed to be essential proteins
Phase 4: April 2009
1AX3
14.7%
Bacillus anthracis
IDP91711
(
show subtarget assignments
)
8
selected
No
NP_006550
5730027
KHDRBS1
KH domain-containing, RNA-binding, signa...
443
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2BL5
14.7%
Homo sapiens
IDP02491
(
show subtarget assignments
)
1
cloned
No
YPO1811
16122063
short chain dehydrogenase [Yersinia pest...
688
Conserved; CD; Drug target functions
Phase 3: June 2008
3U0B
14.8%
Yersinia pestis
Central intermediary metabolism
Other
IDP04358
(
show subtarget assignments
)
1
cloned
No
YPO0895
115346679
creC
putative histidine kinase sensor [Yersin...
472
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
14.8%
Yersinia pestis
Regulatory functions
Other
IDP90401
(
show subtarget assignments
)
8
cloned
No
CT_579
3329021
hypothetical protein [Chlamydia trachoma...
439
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3V47
14.8%
Chlamydia trachomatis
IDP04341
(
show subtarget assignments
)
1
expressed
No
CBU_0634
215919011
putative aerobic respiration control sen...
630
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
14.8%
Coxiella burnetii
Regulatory functions
Protein interactions
IDP91726
(
show subtarget assignments
)
8
selected
No
NP_116784
14670388
BAD
bcl2 antagonist of cell death [Homo sapi...
168
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2BZW
14.9%
Homo sapiens
IDP90207
(
show subtarget assignments
)
8
soluble
No
MYXV_gp152
9633784
m149R
m149R
490
ankyrin motif, similar to VACV-Cop:B4R
Community Requests
1N11
14.9%
Myxoma virus
host range factor
0
IDP91405
(
show subtarget assignments
)
8
in_crystallization_trials
No
VV1_0801
27364250
dehydrogenase [Vibrio vulnificus CMCP6]
313
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3GDO
15%
Vibrio vulnificus
IDP00225
(
show subtarget assignments
)
1
cloned
No
YPO3069
16123246
-
putative exported protein
486
Virulence
Phase 1: October 2007
3C37
15%
Yersinia pestis
Purines, pyrimidines, nucleosides, and nucleotides
2'-Deoxyribonucleotide metabolism
IDP90377
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_274
3328687
hypothetical protein [Chlamydia trachoma...
139
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3KD7
15.1%
Chlamydia trachomatis
IDP04068
(
show subtarget assignments
)
1
expressed
No
YPCD1.94n
40548799
hypothetical protein YPCD1.94n [Yersinia...
251
virulence factor;
Phase 4: April 2009
1A5V
15.1%
Yersinia pestis
IDP91056
(
show subtarget assignments
)
8
expressed
No
AAA42941
323448
viral polyprotein [Dengue virus 2]
3391
potential drug target /
A structure of the co-complex between Dengue 2 strain 16681 full length NS3 and ...
Community Requests
2J7U
15.1%
Dengue virus
IDP01807
(
show subtarget assignments
)
1
cloned
No
FTT0873c
56707977
radA
DNA repair protein RadA [Francisella tul...
456
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
3K1J
15.1%
Francisella tularensis
DNA metabolism
DNA replication, recombination, and repair
IDP05178
(
show subtarget assignments
)
1
expressed
No
BA_3332
30257877
putative S-layer protein [Bacillus anthr...
338
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3PYW
15.1%
Bacillus anthracis
Cell envelope: Surface structures
IDP91738
(
show subtarget assignments
)
8
selected
No
Q5YB85_STRSG
0
598
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1I84
15.1%
Streptococcus sp.
IDP00255
(
show subtarget assignments
)
1
selected
No
NP_041725:276-677
9627243
CFA
Cell fusing agent virus Envelope protein...
402
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
3C5X
15.2%
Cell fusing
IDP04007
(
show subtarget assignments
)
1
expressed
No
VC1319
15641331
sensor histidine kinase [Vibrio cholerae...
440
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
15.2%
Vibrio cholerae
Regulatory functions
Other
IDP04667
(
show subtarget assignments
)
1
cloned
No
GBAA1313
47526578
sensor histidine kinase [Bacillus anthra...
466
putative drug target function;
Phase 4: April 2009
2C2A
15.2%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04415
(
show subtarget assignments
)
8
selected
No
CAC05837
12329106
icsA (virG)
IcsA (VirG), outermembrane protein expos...
1102
Shigella effector protein
Community Requests
3ML3
15.2%
Shigella flexneri
IDP04192
(
show subtarget assignments
)
1
cloned
No
CPF_0671
110799768
phosphoribosylformylglycinamidine syntha...
1266
conserved gene; putative drug target function;
Phase 4: April 2009
3AC6
15.2%
Clostridium perfringens
Purines, pyrimidines, nucleosides, and nucleotides
Purine ribonucleotide biosynthesis
IDP04659
(
show subtarget assignments
)
1
soluble
No
GBAA0272
47525531
sensor histidine kinase [Bacillus anthra...
501
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
15.2%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04428
(
show subtarget assignments
)
1
soluble
No
GBAA4832
47530128
phoR
sensory box histidine kinase PhoR [Bacil...
587
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
15.2%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP05719
(
show subtarget assignments
)
1
soluble
No
BA_1903
30256563
peptidase, M23/M37 family [Bacillus anth...
564
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3SLU
15.2%
Bacillus anthracis
Protein fate: Degradation of proteins, peptides, and glycopeptides
IDP00222
(
show subtarget assignments
)
1
cloned
No
YPO3049
16123226
-
putative binding protein-dependent trans...
589
Virulence
Phase 1: October 2007
3DKN
15.3%
Yersinia pestis
IDP92020
(
show subtarget assignments
)
8
selected
No
TGME49_120640
237841247
cyclophilin, putative [Toxoplasma gondii...
764
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2A2N
15.3%
Toxoplasma gondii
IDP00473
(
show subtarget assignments
)
1
cloned
No
YPO0107
16120454
ftsN
cell division protein FtsN
281
Conserved Gene / Pathway
Phase 2: March 2008
1UTA
15.3%
Yersinia pestis
Cellular processes
Cell division
IDP04240
(
show subtarget assignments
)
1
cloned
No
CPF_1077
110800997
extracellular solute-binding protein [Cl...
477
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2W7Y
15.3%
Clostridium perfringens
Transport and binding proteins
Unknown substrate
IDP02216
(
show subtarget assignments
)
1
cloned
No
GBAA1449
47526724
M23/37 family peptidase [Bacillus anthra...
417
Drug target motif; Conserved; Involved in sporulation; Vaccine Target; Drug targ...
Phase 3: June 2008
2HSI
15.3%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP05059
(
show subtarget assignments
)
1
soluble
No
CD0690
126698269
putative nucleotide phosphodiesterase [C...
655
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3GVE
15.3%
Clostridium difficile
Unknown function: Enzymes of unknown specificity
IDP91337
(
show subtarget assignments
)
8
cloned
No
VV2_0138
27366594
EAL domain-containing protein [Vibrio vu...
588
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2R6O
15.3%
Vibrio vulnificus
IDP04694
(
show subtarget assignments
)
1
soluble
No
GBAA5714
47531051
yycG
sensory box histidine kinase YycG [Bacil...
613
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
15.3%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP01416
(
show subtarget assignments
)
1
soluble
No
VC1410
15641421
multidrug resistance protein VceA
406
Conserved Gene / Pathway
Phase 2: March 2008
4DK1
15.3%
Vibrio cholerae
Transport and binding proteins
Other
IDP04012
(
show subtarget assignments
)
1
cloned
No
CPF_2355
110800506
virJ
sensor histidine kinase [Clostridium per...
482
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
15.4%
Clostridium perfringens
Cellular processes
Pathogenesis
IDP04132
(
show subtarget assignments
)
1
cloned
No
YPO2997
218930046
putative two-component system sensor kin...
449
putative drug target function;
Phase 4: April 2009
3JZ3
15.4%
Yersinia pestis
Regulatory functions
Other
IDP04440
(
show subtarget assignments
)
1
cloned
No
YPO0266
115346083
secretion system apparatus protein [Yers...
682
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
2X49
15.4%
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP91665
(
show subtarget assignments
)
8
selected
No
NP_620278
20357588
TAF1
transcription initiation factor TFIID su...
1872
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3AAD
15.4%
Homo sapiens
IDP90964
(
show subtarget assignments
)
8
purified
No
VC0072
81545617
Sensory box/GGDEF family protein
768
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
15.4%
Vibrio cholerae
IDP01658
(
show subtarget assignments
)
1
in_crystallization_trials
No
Cj0059c
15791451
fliY
flagellar motor switch protein FliY [Cam...
280
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
1O6A
15.4%
Campylobacter jejuni
Cell envelope
Other
IDP02150
(
show subtarget assignments
)
1
cloned
No
lmo1104
16803144
hypothetical protein lmo1104 [Listeria m...
336
Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...
Phase 3: June 2008
2EVR
15.5%
Listeria monocytogenes
Unclassified
Role category not yet assigned
IDP01973
(
show subtarget assignments
)
1
expressed
No
Cj1440c
15792758
putative sugar transferase [Campylobacte...
407
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
2Z86
15.5%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP05496
(
show subtarget assignments
)
1
soluble
No
BA_4047
30258554
cell division protein FtsQ [Bacillus ant...
265
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1YR1
15.5%
Bacillus anthracis
Cellular processes: Cell division
IDP01736
(
show subtarget assignments
)
1
expressed
No
GBAA5503
47530821
sensor histidine kinase [Bacillus anthra...
476
Conserved; Drug target functions
Phase 3: June 2008
2C2A
15.5%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP90963
(
show subtarget assignments
)
8
cloned
No
VP2446
81727013
C-di-GMP phosphodiesterase A-related pro...
679
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
15.5%
Vibrio parahaemolyticus
IDP90951
(
show subtarget assignments
)
8
purified
No
VC0653
81545356
C-di-GMP phosphodiesterase A-related pro...
684
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
15.5%
Vibrio cholerae
IDP00585
(
show subtarget assignments
)
1
expressed
No
YPO0116
16120461
metL
bifunctional aspartate kinase II/homoser...
811
Virulence Associated Factor
Phase 2: March 2008
1EBF
15.5%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP91638
(
show subtarget assignments
)
8
expressed
No
NP_216897
15609518
polyketide synthetase MBTD (polyketide s...
1004
virulence/pathogenesis /
All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...
Community Requests
2HG4
15.5%
Mycobacterium tuberculosis
IDP04420
(
show subtarget assignments
)
1
cloned
No
GBAA3308
47528594
sdhB-1
l-serine dehydratase, iron-sulfur-depend...
232
virulence factor; putative drug target function;
Phase 4: April 2009
2IQQ
15.5%
Bacillus anthracis
Energy metabolism
Amino acids and amines
IDP04669
(
show subtarget assignments
)
1
expressed
No
GBAA1351
47526623
sensor histidine kinase KinD [Bacillus a...
498
putative drug target function;
Phase 4: April 2009
3D36
15.5%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP91443
(
show subtarget assignments
)
8
cloned
No
VV1_0417
27363885
putative chitinase [Vibrio vulnificus CM...
563
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3CQL
15.5%
Vibrio vulnificus
IDP01642
(
show subtarget assignments
)
1
cloned
No
Cj1150c
15792474
waaE
D,D-heptose 1-phosphate adenosyltransfer...
461
Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...
Phase 3: June 2008
2AWD
15.6%
Campylobacter jejuni
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP90091
(
show subtarget assignments
)
8
expressed
No
ZZZ_0007
660
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
2P5Z
15.6%
Escherichia coli
IDP05044
(
show subtarget assignments
)
1
expressed
No
BA_3338
30257881
putative S-layer protein [Bacillus anthr...
360
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3PYW
15.6%
Bacillus anthracis
Cell envelope: Surface structures
IDP04449
(
show subtarget assignments
)
1
cloned
No
YPO0816
218927995
general secretion pathway protein D [Yer...
640
putative drug target function;
Phase 4: April 2009
3EZJ
15.6%
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP90348
(
show subtarget assignments
)
8
expressed
No
CT166
15604885
hypothetical protein CT166 [Chlamydia tr...
639
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3SRZ
15.6%
Chlamydia trachomatis
IDP01829
(
show subtarget assignments
)
1
cloned
No
lmo0051
16802099
hypothetical protein lmo0051 [Listeria m...
242
Known virulence-Regulation; PMID:17675424
Phase 3: June 2008
3BS1
15.7%
Listeria monocytogenes
Regulatory functions
Other
IDP05501
(
show subtarget assignments
)
1
in_crystallization_trials
No
CD0270
126697842
fliM
putative flagellar motor switch protein ...
293
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2HP7
15.7%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP02374
(
show subtarget assignments
)
1
purified
No
GBAA3116
47528407
ppsA
phosphoenolpyruvate synthase [Bacillus a...
868
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
2OLS
15.7%
Bacillus anthracis
Energy metabolism
Glycolysis/gluconeogenesis
IDP05368
(
show subtarget assignments
)
1
soluble
No
BA_3737
30258256
N-acetylmuramoyl-L-alanine amidase, fami...
575
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3HMB
15.7%
Bacillus anthracis
Cell envelope: Surface structures
IDP05420
(
show subtarget assignments
)
1
soluble
No
lmo0066
16802114
-
hypothetical protein lmo0066 [Listeria m...
604
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1QS1
15.7%
Listeria monocytogenes
Hypothetical proteins: Conserved
IDP90175
(
show subtarget assignments
)
8
expressed
No
AAM13468.1
20153007
VGF
CPXV021 protein or CPXV VGF protein
139
similar to viral growth factor C11R vaccinia virus
Community Requests
1K36
15.8%
Cowpox virus
host range protein
0
IDP91731
(
show subtarget assignments
)
8
selected
No
NP_958854
41393583
EGFL7
epidermal growth factor-like protein 7 [...
273
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2W86
15.8%
Homo sapiens
IDP00205
(
show subtarget assignments
)
1
cloned
No
YPO1705
16121965
-
tail-specific protease precursor
690
Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...
Phase 1: October 2007
1FC6
15.8%
Yersinia pestis
IDP01023
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1051
16764411
sseI
secreted effector protein [Phage Gifsy-2...
322
Virulence Associated Factor
Phase 2: March 2008
3CXB
15.8%
Salmonella enterica
Unknown function
General
IDP04399
(
show subtarget assignments
)
1
cloned
No
YPO3613
218930623
putative Rhs accessory genetic element [...
732
virulence factor; putative drug target function;
Phase 4: April 2009
2P5Z
15.8%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP05506
(
show subtarget assignments
)
1
soluble
No
CD1232
126698828
putative lipoprotein [Clostridium diffic...
273
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1NA0
15.8%
Clostridium difficile
Unknown function: General
IDP90966
(
show subtarget assignments
)
8
purified
No
UTI89_C3683
122422243
Hypothetical protein yhdA
646
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3HVB
15.8%
Escherichia coli
IDP90001
(
show subtarget assignments
)
8
cloned
No
FTT0094c
56603762
qseC
sensor histidine kinase
475
Drug Target (Community Request)
Community Requests
3A0R
15.8%
Francisella tularensis
IDP04505
(
show subtarget assignments
)
1
soluble
No
VCA0531
15601291
sensor histidine kinase [Vibrio cholerae...
497
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
15.9%
Vibrio cholerae
Regulatory functions
Other
IDP91939
(
show subtarget assignments
)
8
selected
No
SpneCM_010100003755
298254716
cation diffusion facilitator transporter...
296
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2QFI
15.9%
Streptococcus pneumoniae
IDP90956
(
show subtarget assignments
)
8
cloned
No
UTI89_C1558
122423881
Hypothetical protein yciR
661
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3HVB
15.9%
Escherichia coli
IDP04673
(
show subtarget assignments
)
1
purified
No
GBAA1498
47777938
resE
sensor histidine kinase ResE [Bacillus a...
591
putative drug target function;
Phase 4: April 2009
3A0R
15.9%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP02517
(
show subtarget assignments
)
1
purified
No
GBAA2315
47527614
S-layer protein, putative [Bacillus anth...
383
Drug target motif; Drug target functions
Phase 3: June 2008
3PYW
15.9%
Bacillus anthracis
Cell envelope
Surface structures
IDP00030
(
show subtarget assignments
)
1
purified
No
BA_0926
30254669
tellurium resistance protein, putative
401
Virulence
Phase 1: October 2007
2KXT
16%
Bacillus anthracis
Cellular processes
Toxin production and resistance
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