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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 4 of 60, showing 100 records out of 5973 total, starting on record 301
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP91015
(
show subtarget assignments
)
8
selected
No
y2404
22126288
psn
pesticin/yersiniabactin outer membrane r...
673
TonB-dependent outer membrane receptor (yersiniabactin-binding)
Community Requests
1NQF
23.8%
Yersinia pestis
IDP91016
(
show subtarget assignments
)
8
selected
No
y2451
22126334
hypothetical protein y2451 [Yersinia pes...
384
other biological interest /
putative iron transport protein
Community Requests
3AT7
40.9%
Yersinia pestis
IDP00733
(
show subtarget assignments
)
1
selected
No
SACOL2419
57285149
hlgA
gamma-hemolysin, component A
309
Conserved Gene / Pathway
Phase 2: March 2008
2QK7
90.9%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP91036
(
show subtarget assignments
)
8
selected
No
SDY_P151
82524557
ospC3
OspC3 [Shigella dysenteriae Sd197]
484
virulence/pathogenesis /
A cell surface protein of S. dysenteriae and putative virulence factor secreted ...
Community Requests
Shigella dysenteriae
IDP91521
(
show subtarget assignments
)
8
selected
No
TGME49_040910
237834825
C2 domain-containing protein [Toxoplasma...
1990
potential drug target; virulence/pathogenesis /
DOC2.1 was identified in a temperature sensitive host cell invasion/egress mutan...
Community Requests
Toxoplasma gondii
IDP91522
(
show subtarget assignments
)
8
selected
No
TGGT1_033230
221484314
conserved hypothetical protein [Toxoplas...
610
potential drug target /
Identified in yeast two-hybrid screen with MORN1 as bait and named MIP1 for MORN...
Community Requests
Toxoplasma gondii
IDP91532
(
show subtarget assignments
)
8
selected
No
TC_0728
7190757
omcA
OmcA [Chlamydia muridarum Nigg]
88
vaccine candidate /
Vaccine formulation
Community Requests
Chlamydia muridarum
IDP00514
(
show subtarget assignments
)
1
selected
No
YPO3721
16123859
hemolysin
1635
Conserved Gene / Pathway
Phase 2: March 2008
3FY3
9%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP91534
(
show subtarget assignments
)
8
selected
No
CAA36299
40706
major outer membrane protein precursor [...
395
vaccine candidate /
Vaccine formulation
Community Requests
Chlamydia trachomatis
IDP91535
(
show subtarget assignments
)
8
selected
No
TC_0052
7190091
ompA
major outer membrane protein, porin [Chl...
387
vaccine candidate /
Vaccine formulation
Community Requests
Chlamydia muridarum
IDP91542
(
show subtarget assignments
)
8
selected
No
TGME49_080410
237844275
3',5'-cyclic phosphodiesterase, putative...
1085
potential drug target /
Phosphodiesterases are key regulators of cell signalling pathways and are attrac...
Community Requests
1SO2
11.2%
Toxoplasma gondii
IDP91543
(
show subtarget assignments
)
8
selected
No
TGME49_057080
237831315
cAMP-specific 3',5'-cyclic phosphodieste...
1691
potential drug target /
Phosphodiesterases are key regulators of cell signalling pathways and are attrac...
Community Requests
3ECM
6.6%
Toxoplasma gondii
IDP91548
(
show subtarget assignments
)
8
selected
No
EfaeDRAFT_1579
69245409
Protein of unknown function DUF472 [Ente...
857
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Enterococcus faecium
IDP91591
(
show subtarget assignments
)
8
selected
No
Atu2521
15889786
lpiA
protein regulated by acid pH [Agrobacter...
866
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Agrobacterium tumefaciens
IDP91634
(
show subtarget assignments
)
8
selected
No
AAC16023
2429143
exoU
ExoU [Pseudomonas aeruginosa]
687
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
4AKX
95.8%
Pseudomonas aeruginosa
IDP91660
(
show subtarget assignments
)
8
selected
No
LAMA5_HUMAN
0
3695
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2Y38
9.6%
Homo sapiens
IDP91662
(
show subtarget assignments
)
8
selected
No
NP_004351
4757960
CDH1
cadherin-1 preproprotein [Homo sapiens]
882
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1Q55
57.5%
Homo sapiens
IDP91663
(
show subtarget assignments
)
8
selected
No
NP_005550
38788416
LAMA1
laminin subunit alpha-1 precursor [Homo ...
3075
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2JD4
9.4%
Homo sapiens
IDP91670
(
show subtarget assignments
)
8
selected
No
ANTR2_HUMAN
0
489
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1SHU
37%
Homo sapiens
IDP91671
(
show subtarget assignments
)
8
selected
No
VK03_VACCC
0
88
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1LUZ
98.9%
Vaccinia virus
IDP91673
(
show subtarget assignments
)
8
selected
No
CD44_HUMAN
0
742
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1POZ
21.4%
Homo sapiens
IDP91674
(
show subtarget assignments
)
8
selected
No
CGA1_HELPY
0
1147
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3IEC
6.9%
Helicobacter pylori
IDP91677
(
show subtarget assignments
)
8
selected
No
FLUAVs7gp1
8486123
M1
matrix protein 1 [Influenza A virus (A/P...
252
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1EA3
65.1%
Influenza A
IDP91678
(
show subtarget assignments
)
8
selected
No
H5_VACCW
0
203
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
Vaccinia virus
IDP91681
(
show subtarget assignments
)
8
selected
No
LAMC3_HUMAN
0
1587
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2Y38
8.9%
Homo sapiens
IDP91682
(
show subtarget assignments
)
8
selected
No
MuHV4gp74
9629629
ORF73
nuclear antigen LANA [Murid herpesvirus ...
314
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1I3Q
13.1%
Murid herpesvirus
IDP91686
(
show subtarget assignments
)
8
selected
No
NP_000236
42741655
MET
hepatocyte growth factor receptor isofor...
1390
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2UZX
51.4%
Homo sapiens
IDP00492
(
show subtarget assignments
)
1
selected
No
YPO1559
16121830
hypothetical protein YPO1559
379
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP91688
(
show subtarget assignments
)
8
selected
No
NP_000565
10835143
CD55
complement decay-accelerating factor iso...
381
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3IYP
99.7%
Homo sapiens
IDP91689
(
show subtarget assignments
)
8
selected
No
NP_000706
4502503
C4BPA
C4b-binding protein alpha chain precurso...
597
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2GSX
28.8%
Homo sapiens
IDP91692
(
show subtarget assignments
)
8
selected
No
NP_001093
4501891
ACTN1
alpha-actinin-1 isoform b [Homo sapiens]...
892
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1SJJ
93.3%
Homo sapiens
IDP91693
(
show subtarget assignments
)
8
selected
No
NP_001624
4502067
AMBP
protein AMBP preproprotein [Homo sapiens...
352
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3QKG
51.7%
Homo sapiens
IDP91695
(
show subtarget assignments
)
8
selected
No
NP_002255
222144293
KPNA1
importin subunit alpha-1 [Homo sapiens]
538
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3TJ3
83.1%
Homo sapiens
IDP91696
(
show subtarget assignments
)
8
selected
No
NP_002283
119703755
LAMB2
laminin subunit beta-2 precursor [Homo s...
1798
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2Y38
7.3%
Homo sapiens
IDP91701
(
show subtarget assignments
)
8
selected
No
NP_003053
11321571
SLIT3
slit homolog 3 protein precursor [Homo s...
1523
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2A0Z
11.2%
Homo sapiens
IDP91702
(
show subtarget assignments
)
8
selected
No
NP_003370
21614499
EZR
ezrin [Homo sapiens]
586
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2I1J
56.9%
Homo sapiens
IDP91704
(
show subtarget assignments
)
8
selected
No
NP_004528
4758756
NAP1L1
nucleosome assembly protein 1-like 1 [Ho...
391
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2AYU
35%
Homo sapiens
IDP91705
(
show subtarget assignments
)
8
selected
No
NP_004879
4757818
ATP6V1G1
V-type proton ATPase subunit G 1 [Homo s...
118
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2K88
27.1%
Homo sapiens
IDP91708
(
show subtarget assignments
)
8
selected
No
NP_005615
22538796
CCL25
C-C motif chemokine 25 isoform 1 precurs...
150
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2L4N
18.7%
Homo sapiens
IDP91709
(
show subtarget assignments
)
8
selected
No
NP_006107
5174703
TAB1
TGF-beta-activated kinase 1 and MAP3K7-b...
504
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2J4O
79.6%
Homo sapiens
IDP91711
(
show subtarget assignments
)
8
selected
No
NP_006550
5730027
KHDRBS1
KH domain-containing, RNA-binding, signa...
443
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2BL5
14.7%
Homo sapiens
IDP91712
(
show subtarget assignments
)
8
selected
No
NP_006588
5729877
HSPA8
heat shock cognate 71 kDa protein isofor...
646
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3C7N
85.8%
Homo sapiens
IDP00791
(
show subtarget assignments
)
1
selected
No
SACOL1178
57284463
superantigen-like protein
238
Virulence Associated Factor
Phase 2: March 2008
1M4V
23.9%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP91716
(
show subtarget assignments
)
8
selected
No
NP_009330
6274552
STAT1
signal transducer and activator of trans...
750
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1YVL
91.1%
Homo sapiens
IDP91718
(
show subtarget assignments
)
8
selected
No
NP_060140
109148508
OTUB1
ubiquitin thioesterase OTUB1 [Homo sapie...
271
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
4DDG
90.8%
Homo sapiens
IDP91719
(
show subtarget assignments
)
8
selected
No
NP_066925
10863909
SPINT2
kunitz-type protease inhibitor 2 isoform...
252
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2ODY
21%
Homo sapiens
IDP91722
(
show subtarget assignments
)
8
selected
No
NP_112420
14043070
HNRNPA1
heterogeneous nuclear ribonucleoprotein ...
372
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1L3K
52.7%
Homo sapiens
IDP91723
(
show subtarget assignments
)
8
selected
No
NP_112552
14165435
HNRNPK
heterogeneous nuclear ribonucleoprotein ...
463
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1J5K
18.6%
Homo sapiens
IDP91725
(
show subtarget assignments
)
8
selected
No
NP_116273
41054804
C1orf94
hypothetical protein LOC84970 isoform b ...
408
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
Homo sapiens
IDP91726
(
show subtarget assignments
)
8
selected
No
NP_116784
14670388
BAD
bcl2 antagonist of cell death [Homo sapi...
168
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2BZW
14.9%
Homo sapiens
IDP91732
(
show subtarget assignments
)
8
selected
No
O67990_VIBMI
0
628
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2Y3U
16.6%
Vibrio mimicus
IDP00431
(
show subtarget assignments
)
1
selected
No
YPO3720
16123858
shlB
hemolysin activator protein
561
Virulence Associated Factor
Phase 2: March 2008
2QDZ
25%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP91734
(
show subtarget assignments
)
8
selected
No
PTN11_HUMAN
0
593
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2SHP
88%
Homo sapiens
IDP91735
(
show subtarget assignments
)
8
selected
No
Q4W8J9_STAAU
0
663
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2A1D
29.9%
Staphylococcus aureus
IDP91738
(
show subtarget assignments
)
8
selected
No
Q5YB85_STRSG
0
598
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1I84
15.1%
Streptococcus sp.
IDP91739
(
show subtarget assignments
)
8
selected
No
Q6V4K9_STRPY
0
310
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2XNX
17.1%
Streptococcus pyogenes
IDP91741
(
show subtarget assignments
)
8
selected
No
Q6V4L4_STRPY
0
397
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1I84
22.4%
Streptococcus pyogenes
IDP91742
(
show subtarget assignments
)
8
selected
No
Q6V4L9_STRPY
0
391
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2TMA
18.4%
Streptococcus pyogenes
IDP91746
(
show subtarget assignments
)
8
selected
No
Q8BDF8_9POXV
0
500
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
Vaccinia virus
IDP91747
(
show subtarget assignments
)
8
selected
No
Q8WLQ7_HUMAN
0
79
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1D5M
94.9%
Homo sapiens
IDP91749
(
show subtarget assignments
)
8
selected
No
Q9DUM3_HHV8
0
1036
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3H0G
9.3%
Human herpesvirus
IDP91750
(
show subtarget assignments
)
8
selected
No
SPG2_STRSG
0
593
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2KN4
12.1%
Streptococcus sp.
IDP91753
(
show subtarget assignments
)
8
selected
No
TSST_STAAU
0
234
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2IJ0
82.5%
Staphylococcus aureus
IDP91754
(
show subtarget assignments
)
8
selected
No
TVB1_HUMAN
0
116
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3UTP
80.2%
Homo sapiens
IDP91756
(
show subtarget assignments
)
8
selected
No
VF01_VACCP
0
206
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2VTY
81.1%
Vaccinia virus
IDP91757
(
show subtarget assignments
)
8
selected
No
VF01_VACCW
0
226
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2VTY
73%
Vaccinia virus
IDP91799
(
show subtarget assignments
)
8
selected
No
AAL27442
16612079
vanE
VanE [Enterococcus faecalis]
352
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1E4E
41.5%
Enterococcus faecalis
IDP91804
(
show subtarget assignments
)
8
selected
No
ZP_04523236
237510521
putative polyketide synthase PksL (PKS) ...
4567
virulence/pathogenesis /
Emerging evidence suggests that natural products from pathogenic organisms are i...
Community Requests
2HG4
5.4%
Burkholderia pseudomallei
IDP91806
(
show subtarget assignments
)
8
selected
No
ZP_04520447
237507732
putative polyketide synthase PksJ (PKS) ...
5053
virulence/pathogenesis /
Emerging evidence suggests that natural products from pathogenic organisms are i...
Community Requests
2VSQ
5.6%
Burkholderia pseudomallei
IDP91808
(
show subtarget assignments
)
8
selected
No
AAB07788
924760
CTCF
CTCF [Homo sapiens]
727
innate immunity /
CTCF (CCCTC-binding factor) is an evolutionarily-conserved transcription factor ...
Community Requests
1X6H
10.2%
Homo sapiens
IDP01752
(
show subtarget assignments
)
1
selected
No
GBAA5282
47778383
nprB
neutral protease B [Bacillus anthracis s...
547
Drug target motif; Conserved; Vaccine Target; Drug target functions
Phase 3: June 2008
1KEI
31.1%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP91834
(
show subtarget assignments
)
8
selected
No
HMPREF9176_0709
312864359
DNA-binding helix-turn-helix protein [St...
300
Proteins of the ComR family of Rgg regulators are important for horiz...
Community Requests
Streptococcus downei
IDP91836
(
show subtarget assignments
)
8
selected
No
GALLO_0038
288904261
Cro/CI family transcriptional regulator ...
299
Proteins of the ComR family of Rgg regulators are important for horiz...
Community Requests
Streptococcus gallolyticus
IDP91836
(
show subtarget assignments
)
8
selected
No
GALLO_0038
288904261
Cro/CI family transcriptional regulator ...
299
Proteins of the ComR family of Rgg regulators are important for horiz...
Community Requests
Streptococcus gallolyticus
IDP91840
(
show subtarget assignments
)
8
selected
No
Spy49_0449c
209559004
positive regulator [Streptococcus pyogen...
283
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus pyogenes
IDP91841
(
show subtarget assignments
)
8
selected
No
stu0182
55820280
MutR family transcriptional regulator [S...
238
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus thermophilus
IDP91846
(
show subtarget assignments
)
8
selected
No
SSU1789
253754475
DNA-binding protein [Streptococcus suis ...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus suis
IDP91847
(
show subtarget assignments
)
8
selected
No
STER_0934
116627734
XRE family transcriptional regulator [St...
285
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus thermophilus
IDP91851
(
show subtarget assignments
)
8
selected
No
SDEG_1013
251782424
XRE family transcriptional regulator [St...
295
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus dysgalactiae
IDP91852
(
show subtarget assignments
)
8
selected
No
SZO_12400
225868818
DNA-binding protein [Streptococcus equi ...
289
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus equi
IDP91855
(
show subtarget assignments
)
8
selected
No
STER_1299
116628056
XRE family transcriptional regulator [St...
291
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus thermophilus
IDP91856
(
show subtarget assignments
)
8
selected
No
SPH_0253
169834104
MutR [Streptococcus pneumoniae Hungary19...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus pneumoniae
IDP91870
(
show subtarget assignments
)
8
selected
No
CAA30578
38663
unnamed protein product [Acinetobacter b...
259
drug resistance /
confers resistance to aminoglycoside antibiotics by phosphorylation
Community Requests
2BKK
34.4%
Acinetobacter baumannii
IDP91871
(
show subtarget assignments
)
8
selected
No
AAB05624
1209528
vanYB
D,D-carboxypeptidase [Enterococcus faeca...
268
drug resistance /
confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...
Community Requests
Enterococcus faecalis
IDP91877
(
show subtarget assignments
)
8
selected
No
CAB89086
7649401
fox-4
beta-lactamase class C [Escherichia coli...
382
potential drug target /
Dissemination of plasmid-mediated class C ?-lactamases is currently a critical c...
Community Requests
1ZKJ
71.7%
Escherichia coli
IDP91878
(
show subtarget assignments
)
8
selected
No
pVEF1_014
121633839
vanB
VanA protein [Enterococcus faecium]
343
drug resistance /
The proteins play important roles in vancomycin resistance of Entercocci.
Community Requests
1E4E
98.8%
Enterococcus faecium
IDP91891
(
show subtarget assignments
)
8
selected
No
SpneCM_010100007700
298255470
putative glutamine-binding protein precu...
254
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2V25
41.7%
Streptococcus pneumoniae
IDP91892
(
show subtarget assignments
)
8
selected
No
SpneCM_010100009040
298255720
DNA translocase ftsk [Streptococcus pneu...
741
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2IUT
33.5%
Streptococcus pneumoniae
IDP91894
(
show subtarget assignments
)
8
selected
No
SpneCM_010100007895
298255505
peptidase, M50 family protein [Streptoco...
362
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP91895
(
show subtarget assignments
)
8
selected
No
SpneCM_010100000537
298254086
YitT family protein [Streptococcus pneum...
313
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP91899
(
show subtarget assignments
)
8
selected
No
SpneCM_010100002520
298254473
ABC transporter, ATP-binding/permease pr...
564
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3QF4
39.1%
Streptococcus pneumoniae
IDP91900
(
show subtarget assignments
)
8
selected
No
SpneCM_010100003670
298254699
ABC transporter, ATP-binding/permease pr...
581
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3B5X
32.9%
Streptococcus pneumoniae
IDP91902
(
show subtarget assignments
)
8
selected
No
SpneCM_010100007650
298255460
phosphate ABC transporter, permease prot...
294
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3DHW
14.3%
Streptococcus pneumoniae
IDP91903
(
show subtarget assignments
)
8
selected
No
SpneCM_010100005798
298255108
hypothetical protein SpneCM_05798 [Strep...
663
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2DHR
40.7%
Streptococcus pneumoniae
IDP91906
(
show subtarget assignments
)
8
selected
No
SpneCMD_010100004020
298229824
zinc metalloprotease ZmpB [Streptococcus...
1902
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP91907
(
show subtarget assignments
)
8
selected
No
SpneCM_010100004287
298254820
cell division protein DivIB [Streptococc...
406
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP91909
(
show subtarget assignments
)
8
selected
No
SpneCM_010100002785
298254524
cell wall surface anchor family protein,...
246
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP91910
(
show subtarget assignments
)
8
selected
No
SpneCM_010100003565
298254678
surface protein PspC, partial [Streptoco...
187
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2GRX
25.7%
Streptococcus pneumoniae
IDP92053
(
show subtarget assignments
)
8
selected
No
TGME49_054900
237840493
proteasome subunit beta type 2, putative...
191
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1IRU
49%
Toxoplasma gondii
IDP92052
(
show subtarget assignments
)
8
selected
No
TGME49_053800
237840277
ribosomal protein L15, putative [Toxopla...
287
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
Toxoplasma gondii
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