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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP90254
(
show subtarget assignments
)
8
selected
No
AAK67494
21263110
ie1
IE1 protein [Human herpesvirus 6]
1078
(From requester) The IE1 protein of HHV-6, one of the first viral proteins synth...
Community Requests
Human herpesvirus
IDP00341
(
show subtarget assignments
)
1
cloned
No
FTT1305c
56708363
murA
UDP-N-acetylglucosamine 1-carboxyvinyltr...
444
Drug Target Function
Phase 2: March 2008
3SG1
32.7%
Francisella tularensis
IDP90129
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_084
68449158
myristylprotein [Monkeypox virus]
340
similar to VACV-COP-G9R, MPXV-ZAI96-G10R
Community Requests
Monkeypox virus
IDP90332
(
show subtarget assignments
)
8
cloned
No
CT_421.1
3522895
hypothetical protein [Chlamydia trachoma...
53
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90126
(
show subtarget assignments
)
8
expressed
No
MPXV_ZAI1979_005_044
68449118
unknown [Monkeypox virus]
212
thiol substrate, similar to VACV-COP-F9L, MPXV-ZAI96-C15L
Community Requests
1YPY
21.7%
Monkeypox virus
IDP90304
(
show subtarget assignments
)
8
soluble
No
CT_671
3329122
hypothetical protein [Chlamydia trachoma...
283
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90331
(
show subtarget assignments
)
8
selected
No
CT_874
3329350
pmpI
Putative Outer Membrane Protein I [Chlam...
878
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90123
(
show subtarget assignments
)
8
in_crystallization_trials
No
MPXV_ZAI1979_005_035
68449109
B15R-like protein [Monkeypox virus]
149
similar to VACV-COP-K7R, MPXV-ZAI96-C6R
Community Requests
2K36
94%
Monkeypox virus
IDP90124
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_036
68449110
unknown [Monkeypox virus]
219
mitochondrial-associated inhibitor of apoptosis, similar to VACV-COP-F1L, MPXV-Z...
Community Requests
2VTY
69.4%
Monkeypox virus
IDP90125
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_038
68449112
kelch-like protein [Monkeypox virus]
485
similar to VACV-COP-F3L, MPXV-ZAI96-C9L
Community Requests
1ZGK
13.6%
Monkeypox virus
IDP90253
(
show subtarget assignments
)
0
work_stopped
No
SAR1776
49483939
pyk
pyruvate kinase [Staphylococcus aureus s...
585
(From requester) Potential drug target
Community Requests
3T05
100%
Staphylococcus aureus
IDP90333
(
show subtarget assignments
)
8
soluble
No
CT_606.1
3522903
hypothetical protein [Chlamydia trachoma...
79
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90336
(
show subtarget assignments
)
8
cloned
No
CT_849.1
3522913
hypothetical protein [Chlamydia trachoma...
62
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90128
(
show subtarget assignments
)
8
purified
No
MPXV_ZAI1979_005_060
68449134
myristylprotein [Monkeypox virus]
166
has N-myristyltransferase target MGxxxS/T/A, similar to VACV-COP-E7R, MPXV-ZAI96...
Community Requests
Monkeypox virus
IDP01168
(
show subtarget assignments
)
1
expressed
No
GBAA_pXO2_0084
47566748
capsule synthesis trans-acting positive ...
483
Virulence Associated Factor
Phase 2: March 2008
3SQN
8.5%
Bacillus anthracis
IDP90335
(
show subtarget assignments
)
8
soluble
No
CT_652.1
3522906
hypothetical protein [Chlamydia trachoma...
59
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90127
(
show subtarget assignments
)
8
expressed
No
MPXV_ZAI1979_005_045
68449119
ser/thr kinase [Monkeypox virus]
439
similar to VACV-COP-F10L, MPXV-ZAI96-C16L
Community Requests
Monkeypox virus
IDP90334
(
show subtarget assignments
)
8
cloned
No
CT_421.2
3522896
hypothetical protein [Chlamydia trachoma...
53
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01531
(
show subtarget assignments
)
1
in_pdb
3EFB
No
SF4094
56384059
sorC
probable sor-operon regulator [Shigella ...
315
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 3: June 2008
2W48
86.3%
Shigella flexneri
IDP90162
(
show subtarget assignments
)
8
purified
No
CD1833
123174272
3-dehydroquinate synthase
354
Potential drug target. Shikimate pathway enzyme
Community Requests
3OKF
40.1%
Clostridium difficile
IDP90133
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_159
68449233
CD47-like putative membrane protein [Mon...
277
similar to VACV-COP-A38L, MPXV-ZAI96-A40L
Community Requests
2JJS
11.6%
Monkeypox virus
IDP90293
(
show subtarget assignments
)
8
in_pdb
3OTR
No
TGME49_068860
211963243
enolase 1 [Toxoplasma gondii ME49]
444
Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...
Community Requests
3OTR
100%
Toxoplasma gondii
IDP90315
(
show subtarget assignments
)
8
cloned
No
CT_744
3329204
CHLTR possible phosphoprotein [Chlamydia...
821
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90292
(
show subtarget assignments
)
8
cloned
No
TGGT1_004130
221483205
histone acetyltransferase GCN5, putative...
1169
The histone acetyltransferase TgGCN-5A acetylates prerentially Histone 3 [K18], ...
Community Requests
1Z4R
8.5%
Toxoplasma gondii
IDP90415
(
show subtarget assignments
)
8
cloned
No
CT_443
3328874
omcB
60kDa Cysteine-Rich OMP [Chlamydia trach...
553
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90422
(
show subtarget assignments
)
8
cloned
No
CT_471
3328905
hypothetical protein [Chlamydia trachoma...
200
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90132
(
show subtarget assignments
)
8
expressed
No
MPXV_ZAI1979_005_155
68449229
unknown [Monkeypox virus]
176
similar to VACV-COP-A35R, MPXV-ZAI96-A37R
Community Requests
Monkeypox virus
IDP90108
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_013
68449087
bifunctional zinc finger-like protein/E3...
242
similar to VARV BEN68-zinc finger-like protein
Community Requests
2ECW
8.3%
Monkeypox virus
IDP90081
(
show subtarget assignments
)
8
cloned
No
ABD79034.1
89892477
M2
matrix protein 2 [Influenza A virus (A/U...
96
Influenza matrix protein 2 (M2) is a validated therapeutic target whose on-marke...
Community Requests
2L0J
42.7%
Influenza A
IDP01530
(
show subtarget assignments
)
1
in_pdb
3EFV
3ETF
No
STM1524
16764869
yneI
putative succinate-semialdehyde dehydrog...
462
It is an essential gene in Salmonella which is important in energy metabolism.
Phase 3: June 2008
3EFV
100%
Salmonella enterica
IDP90275
(
show subtarget assignments
)
8
soluble
No
TGME49_030450
211965620
GMP synthase, putative [Toxoplasma gondi...
569
Guanosine monophosphate synthetase is essential for the synthesis of GMP in puri...
Community Requests
1GPM
51%
Toxoplasma gondii
IDP90340
(
show subtarget assignments
)
8
expressed
No
CT_696
6578111
hypothetical protein [Chlamydia trachoma...
392
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01519
(
show subtarget assignments
)
1
purified
No
VC2149
15642148
hypothetical protein VC2149
95
Drug Target Function
Phase 2: March 2008
3KE2
43.2%
Vibrio cholerae
IDP90342
(
show subtarget assignments
)
8
expressed
No
CT155
15604874
phospholipase D endonuclease superfamily...
313
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90344
(
show subtarget assignments
)
8
cloned
No
CT105
15604824
hypothetical protein CT105 [Chlamydia tr...
656
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90000
(
show subtarget assignments
)
8
cloned
No
FTT1352
56708408
hypothetical protein FTT1352
383
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Francisella tularensis
IDP01540
(
show subtarget assignments
)
1
in_pdb
3EC6
No
GBAA0418
47525694
general stress protein 26 [Bacillus anth...
138
CONSERVED
Phase 3: June 2008
3EC6
100%
Bacillus anthracis
IDP90411
(
show subtarget assignments
)
8
expressed
No
CT_647
3329096
hypothetical protein [Chlamydia trachoma...
192
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90135
(
show subtarget assignments
)
8
expressed
No
MPXV_ZAI1979_005_174
68449246
kelch-like protein [Monkeypox virus]
82
similar to part of VACV-COP-A55R, MPXV-ZAI96-B1R
Community Requests
Monkeypox virus
IDP90134
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_166
68449240
Toll/IL1-receptor [TIR]-like protein [Mo...
240
similar to VACV-COP-A46R, MPXV-ZAI96-A47R
Community Requests
Monkeypox virus
IDP90271
(
show subtarget assignments
)
8
in_pdb
3M5R
3M8A
No
ACP44186
227977167
NS1
nonstructural protein 1 [Influenza A vir...
219
swine flu virus
Community Requests
3F5T
79.9%
Influenza A
IDP90001
(
show subtarget assignments
)
8
cloned
No
FTT0094c
56603762
qseC
sensor histidine kinase
475
Drug Target (Community Request)
Community Requests
3A0R
15.8%
Francisella tularensis
IDP90349
(
show subtarget assignments
)
8
expressed
No
CT461
15605188
yaeI
phosphohydrolase [Chlamydia trachomatis ...
329
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90163
(
show subtarget assignments
)
8
in_pdb
3JS3
No
CD2217
172044608
aroD
3-dehydroquinate dehydratase (3-dehydroq...
255
Potential drug target. Shikimate pathway enzyme
Community Requests
3JS3
100%
Clostridium difficile
IDP00175
(
show subtarget assignments
)
1
soluble
No
YPO1471
16121746
-
putative ATPase subunit of ATP-dependent...
880
Virulence
Phase 1: October 2007
1QVR
36.9%
Yersinia pestis
IDP90345
(
show subtarget assignments
)
8
cloned
No
CT157
15604876
phospholipase D endonuclease superfamily...
404
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1BYR
8.9%
Chlamydia trachomatis
IDP90412
(
show subtarget assignments
)
8
expressed
No
CT_657
3329107
hypothetical protein [Chlamydia trachoma...
105
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90348
(
show subtarget assignments
)
8
expressed
No
CT166
15604885
hypothetical protein CT166 [Chlamydia tr...
639
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3SRZ
15.6%
Chlamydia trachomatis
IDP90347
(
show subtarget assignments
)
8
soluble
No
CT205
15604925
pfkA_1
diphosphate--fructose-6-phosphate 1-phos...
553
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1KZH
36.9%
Chlamydia trachomatis
IDP90517
(
show subtarget assignments
)
8
in_pdb
3UGS
No
Cj0824
15792162
uppS
undecaprenyl diphosphate synthase [Campy...
222
Predicted Essential
Community Requests
3UGS
100%
Campylobacter jejuni
IDP90003
(
show subtarget assignments
)
8
crystallized
No
FTT1103
56708183
conserved hypothetical lipoprotein
365
(Community Request)
Community Requests
3GYK
12.3%
Francisella tularensis
IDP90007
(
show subtarget assignments
)
8
cloned
No
Z4378
12517596
qseC
quorum sensing Escherichia coli regulato...
449
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3JZ3
47%
Escherichia coli
IDP90136
(
show subtarget assignments
)
8
expressed
No
MPXV_ZAI1979_005_177
68449248
ser/thr kinase [Monkeypox virus]
299
essential for viral DNA replication, similar to VACV-COP-B1R, MPXV-ZAI96-B3R
Community Requests
2V62
40.4%
Monkeypox virus
IDP90107
(
show subtarget assignments
)
8
expressed
No
MPXV_ZAI1979_005_012
68449086
interleukin-1 receptor antagonist-like p...
83
similar to VACV-COP-C10L, MPXV-ZAI96-D4L
Community Requests
Monkeypox virus
IDP90137
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_179
68449250
ankyrin-like protein [Monkeypox virus]
561
similar to VACV-COP-B4R, MPXV-ZAI96-B5R
Community Requests
1N11
11.2%
Monkeypox virus
IDP01174
(
show subtarget assignments
)
1
expressed
No
BA_2823
30257425
hypothetical protein BA_2823
375
Drug Target Function
Phase 2: March 2008
Bacillus anthracis
IDP90139
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_182
68449253
bifunctional 21kDa precursor protein of ...
182
virulence, ER resident, similar to VACV-COP-B7R, N-terminal signal peptide, bifu...
Community Requests
Monkeypox virus
IDP90138
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_181
68449252
ankyrin-like protein [Monkeypox virus]
119
similar to VACV-COP-B6R, MPXV-ZAI96-B7R
Community Requests
Monkeypox virus
IDP90161
(
show subtarget assignments
)
8
purified
No
CD1835
123174273
Chorismate synthase (5-enolpyruvylshikim...
359
Potential drug target. Shikimate pathway enzyme
Community Requests
1UM0
38.7%
Clostridium difficile
IDP90353
(
show subtarget assignments
)
8
expressed
No
CT198
15604918
oppA_3
oligopeptide binding protein [Chlamydia ...
518
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1UIU
25.5%
Chlamydia trachomatis
IDP00183
(
show subtarget assignments
)
1
cloned
No
YPO0613
16120939
-
putative permease protein
293
Virulence
Phase 1: October 2007
2R6G
22.5%
Yersinia pestis
IDP90141
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_186
68449257
ser/thr protein kinase-like protein [Mon...
282
similar to VACV-COP-B12R, MPXV-ZAI96-B11R
Community Requests
2KTY
32.4%
Monkeypox virus
IDP90311
(
show subtarget assignments
)
8
cloned
No
CT_734
3329192
hypothetical protein [Chlamydia trachoma...
221
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90352
(
show subtarget assignments
)
8
expressed
No
CT262
15604983
hypothetical protein CT262 [Chlamydia tr...
256
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2CZL
32%
Chlamydia trachomatis
IDP90142
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_188
68449259
unknown [Monkeypox virus]
149
similar to VACV-COP-B15R, MPXV-ZAI96-B13R
Community Requests
2VVY
93.3%
Monkeypox virus
IDP90537
(
show subtarget assignments
)
8
purified
No
Q9KL24
21542209
RecName: Full=Dihydroorotase; Short=DHOa...
342
Predicted Essential
Community Requests
1XGE
55%
Vibrio cholerae
IDP90106
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_011
68449085
secreted epidermal growth factor-like pr...
142
similar to VACV-COP-C11R, MPXV-ZAI96-D3R
Community Requests
1K36
16.2%
Monkeypox virus
IDP90358
(
show subtarget assignments
)
8
expressed
No
CT273
15604994
hypothetical protein CT273 [Chlamydia tr...
188
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90105
(
show subtarget assignments
)
8
expressed
No
MPXV_ZAI1979_005_008
68449082
unknown [Monkeypox virus]
56
similar to part of CPXV-GRI-C3L
Community Requests
Monkeypox virus
IDP90147
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_194
68449266
kelch-like protein [Monkeypox virus]
70
similar to CPXV-GRI-B19R, MPXV-ZAI96-B18R
Community Requests
2Q81
31.4%
Monkeypox virus
IDP90005
(
show subtarget assignments
)
8
soluble
No
Z4377
12517595
qseB
quorum sensing Escherichia coli regulato...
219
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3Q9S
41.1%
Escherichia coli
IDP90150
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_202
68449275
unknown [Monkeypox virus]
176
similar to CPXV-GRI-C2L, MPXV-ZAI96-N3R
Community Requests
Monkeypox virus
IDP90145
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_192
68449264
IFN-alpha/beta-receptor-like secreted gl...
352
similar to VACV-COP-B19R, MPXV-ZAI96-B16R
Community Requests
3OQ3
83.2%
Monkeypox virus
IDP90146
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_193
68449265
ankyrin-like protein [Monkeypox virus]
789
similar to VACV-COP-B20R, MPXV-ZAI96-B17R
Community Requests
1MJ0
5.2%
Monkeypox virus
IDP90149
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_195.5
68449268
serine protease inhibitor-like SPI-1 pro...
357
similar to part of VACV-COP-C12L, MPXV-ZAI96-B19R
Community Requests
1F0C
42%
Monkeypox virus
IDP90359
(
show subtarget assignments
)
8
cloned
No
CT794.1
15605528
hypothetical protein CT794.1 [Chlamydia ...
95
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90365
(
show subtarget assignments
)
8
cloned
No
CT_102
3328499
hypothetical protein [Chlamydia trachoma...
153
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90364
(
show subtarget assignments
)
8
expressed
No
CT_083
3328478
hypothetical protein [Chlamydia trachoma...
160
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90360
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_016
3328405
hypothetical protein [Chlamydia trachoma...
242
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90363
(
show subtarget assignments
)
8
cloned
No
CT_066
3328460
hypothetical protein [Chlamydia trachoma...
158
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90148
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_195
68449267
serine protease inhibitor-like SPI-1 pro...
71
similar to part of VACV-COP-C12L, MPXV-ZAI96-B19R
Community Requests
Monkeypox virus
IDP90361
(
show subtarget assignments
)
8
cloned
No
CT_021
3328411
hypothetical protein [Chlamydia trachoma...
247
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00003
(
show subtarget assignments
)
1
expressed
No
GBAA_pXO1_0158
47566470
gerXC
spore germination protein xc, (pxo1-112)...
317
Drug Target Homolog
Phase 1: October 2007
Bacillus anthracis
IDP90224
(
show subtarget assignments
)
8
in_pdb
3I0U
No
CP0010
31983551
OspF
Shigella OspF effector
239
Shigella OspF effector
Community Requests
3I0U
90.8%
Shigella flexneri
IDP90249
(
show subtarget assignments
)
8
soluble
No
VC2645
15642640
acetylornithine deacetylase [Vibrio chol...
378
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2F7V
26.8%
Vibrio cholerae
IDP90091
(
show subtarget assignments
)
8
expressed
No
ZZZ_0007
660
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
2P5Z
15.6%
Escherichia coli
IDP00196
(
show subtarget assignments
)
1
cloned
No
YPO1051
16121351
-
putative membrane protein
451
Virulence
Phase 1: October 2007
2ZPL
13.5%
Yersinia pestis
IDP90111
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_017
68449091
ankyrin-like protein [Monkeypox virus]
630
similar to VACV-COP-C9L, MPXV-ZAI96-D9L
Community Requests
3NOC
5.1%
Monkeypox virus
IDP00197
(
show subtarget assignments
)
1
purified
No
YPO1233
16121519
-
putative prophage repressor protein
240
Similar to Essential SALTY
Phase 1: October 2007
3BDN
46.2%
Yersinia pestis
IDP90085
(
show subtarget assignments
)
8
purified
No
ZZZ_0001
158
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP00198
(
show subtarget assignments
)
1
cloned
No
YPO1367
16121647
-
conserved hypothetical protein
106
Similar to Essential SALTY
Phase 1: October 2007
1MBU
84.9%
Yersinia pestis
IDP90094
(
show subtarget assignments
)
8
cloned
No
ZZZ_0010
358
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90372
(
show subtarget assignments
)
8
expressed
No
CT_253
3328664
hypothetical protein [Chlamydia trachoma...
215
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90110
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_015
68449089
ankyrin-like protein [Monkeypox virus]
660
similar to CPXV-GRI-C9L,CPXV-BR-V024, MPXV-ZAI96-D7L
Community Requests
1N0Q
4.4%
Monkeypox virus
IDP90083
(
show subtarget assignments
)
8
cloned
No
ZP_01795671
145640077
hypothetical protein CGSHiII_00664 [Haem...
219
The protein we would like structure analyzed is from Haemophilus influenzae. Pri...
Community Requests
2XM6
35.6%
Haemophilus influenzae
IDP90102
(
show subtarget assignments
)
8
expressed
No
MPXV_ZAI1979_005_002
68449079
TNF-alpha-receptor-like protein [Monkeyp...
348
similar to VACV-COP-C22L/B28R, MPXV-ZAI96-J2L/J2R
Community Requests
3ON9
23.6%
Monkeypox virus
IDP90084
(
show subtarget assignments
)
8
soluble
No
ZP_01795673
145640079
hypothetical protein CGSHiII_00674 [Haem...
148
The protein we would like structure analyzed is from Haemophilus influenzae. Pri...
Community Requests
2XM6
28.4%
Haemophilus influenzae
IDP01167
(
show subtarget assignments
)
1
expressed
No
GBAA_pXO2_0060
47566729
capsule synthesis trans-acting positive ...
482
Virulence Associated Factor
Phase 2: March 2008
3SQN
22%
Bacillus anthracis
IDP90600
(
show subtarget assignments
)
8
cloned
No
VC0190
15640220
uvrD
DNA-dependent helicase II [Vibrio choler...
723
Predicted Essential
Community Requests
2IS1
66.8%
Vibrio cholerae
IDP90599
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj0460
15791824
nusA
transcription elongation factor NusA [Ca...
362
Predicted Essential
Community Requests
1HH2
33.4%
Campylobacter jejuni
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