Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04004 (show subtarget assignments)	1	cloned	No	CPF_1305	110799423	mtnN	5'-methylthioadenosine/S-adenosylhomocys...	266	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3EEI	34.6%	Clostridium perfringens	Central intermediary metabolism	Other

IDP90930 (show subtarget assignments)	8	cloned	No	YPO3384	16123533	mtn	5'-methylthioadenosine/S-adenosylhomocys...	233	Predicted Essential	Community Requests	1JYS	74.7%	Yersinia pestis

IDP05499 (show subtarget assignments)	1	soluble	No	BA_4322	30258823		5'-nucleotidase family protein [Bacillus...	529	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Z1A	30.2%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01184 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0267	41016866		60 kDa chaperonin (Protein Cpn60) (groEL...	544	Conserved Gene / Pathway	Phase 2: March 2008	1WE3	67.1%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP90415 (show subtarget assignments)	8	cloned	No	CT_443	3328874	omcB	60kDa Cysteine-Rich OMP [Chlamydia trach...	553	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02565 (show subtarget assignments)	1	soluble	No	CBU_0648	29541249	ribH	6,7-dimethyl-8-ribityllumazine synthase ...	151	Conserved; Drug target functions	Phase 3: June 2008	1VSW	47.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP91190 (show subtarget assignments)	1	in_crystallization_trials	No	EF_A0061	29345308		6'-aminoglycoside N-acetyltransferase [E...	479	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3R6Z	20%	Enterococcus faecalis

IDP90140 (show subtarget assignments)	8	expressed	No	MPXV_ZAI1979_005_184	68449255		6kDa intracellular viral protein [Monkey...	221	similar to VACV-COP-B9R, MPXV-ZAI96-B10R	Community Requests			Monkeypox virus

IDP02041 (show subtarget assignments)	1	in_crystallization_trials	No	STM3051	16766352	bglA	6-phospho-beta-glucosidase A [Salmonella...	477	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	2XHY	95.4%	Salmonella enterica	Energy metabolism	Other

IDP04454 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1254	218928409	bglA	6-phospho-beta-glucosidase [Yersinia pes...	478	drug target; putative drug target function;	Phase 4: April 2009	2XHY	77.8%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01635 (show subtarget assignments)	1	soluble	No	GBAA4844	47530139	pfkA	6-phosphofructokinase [Bacillus anthraci...	319	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3U39	86.5%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP91811 (show subtarget assignments)	8	soluble	No	b3916	1790350	pfkA	6-phosphofructokinase I [Escherichia col...	320	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1PFK	100%	Escherichia coli

IDP91827 (show subtarget assignments)	8	soluble	No	b1723	1788017	pfkB	6-phosphofructokinase II [Escherichia co...	309	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	3CQD	100%	Escherichia coli

IDP90255 (show subtarget assignments)	8	purified	No	SAR1777	49483940	pfkA	6-phosphofructokinase [Staphylococcus au...	322	(From requester) Identified as potential drug target for S. aureus MRSA. Am curr...	Community Requests	3U39	59.3%	Staphylococcus aureus

IDP02226 (show subtarget assignments)	1	crystallized	No	GBAA0164	47525422	yqjI	6-phosphogluconate dehydrogenase [Bacill...	469	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2W8Z	72.3%	Bacillus anthracis	Energy metabolism	Pentose phosphate pathway

IDP00329 (show subtarget assignments)	1	cloned	No	Cj1724c	15793027		7-cyano-7-deazaguanine reductase	127	Drug Target Function	Phase 2: March 2008			Campylobacter jejuni	Amino acid biosynthesis	Pyruvate family

IDP04629 (show subtarget assignments)	1	soluble	No	CBU_0151	29653509	queF	7-cyano-7-deazaguanine reductase [Coxiel...	278	drug target; conserved gene;	Phase 4: April 2009	3BP1	51.4%	Coxiella burnetii	Hypothetical proteins	Conserved

IDP01680 (show subtarget assignments)	0	work_stopped	No	VC0902	161582018	queF	7-cyano-7-deazaguanine reductase [Vibrio...	281	Conserved; Drug target homolg; Drug target functions	Phase 3: June 2008	3BP1	100%	Vibrio cholerae	N/A	N/A

IDP00937 (show subtarget assignments)	1	cloned	No	STM0795	16764158	bioF	8-amino-7-oxononanoate synthase	385	Conserved Gene / Pathway	Phase 2: March 2008	1BS0	80%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04426 (show subtarget assignments)	1	expressed	No	GBAA4339	47529636	bioF	8-amino-7-oxononanoate synthase [Bacillu...	395	putative drug target function;	Phase 4: April 2009	3A2B	33.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02629 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1006	29541588	bioF	8-amino-7-oxononanoate synthase [Coxiell...	384	Conserved; Drug target functions	Phase 3: June 2008	1BS0	37.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01953 (show subtarget assignments)	1	soluble	No	FTT0936c	56708033	bioF	8-amino-7-oxononanoate synthase [Francis...	375	Conserved; Drug target functions	Phase 3: June 2008	1BS0	32%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP90423 (show subtarget assignments)	8	cloned	No	CT_444	3328876	omcA	9kDa-Cysteine-Rich Lipoprotein [Chlamydi...	88	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP91869 (show subtarget assignments)	8	in_pdb 4E8O	No	AAC41391	547387	aac(6')-Ih	aac(6')-Ih [Acinetobacter baumannii]	146	drug resistance / confers resistance to aminoglycoside antibiotics by acetylation	Community Requests	4E8O	100%	Acinetobacter baumannii

IDP91330 (show subtarget assignments)	8	soluble	No	VV2_0263	27366712		ABC transporter ATPase [Vibrio vulnificu...	551	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91078 (show subtarget assignments)	8	cloned	No	CBU_0856	29541449		ABC transporter, ATP-binding/permease pr...	596	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5X	42.3%	Coxiella burnetii

IDP91084 (show subtarget assignments)	8	cloned	No	BA_2444	30262443		ABC transporter, ATP-binding/permease pr...	598	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3QF4	44.5%	Bacillus anthracis

IDP91083 (show subtarget assignments)	8	cloned	No	BA_0528	30260686		ABC transporter, ATP-binding/permease pr...	586	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	2HYD	58.2%	Bacillus anthracis

IDP91079 (show subtarget assignments)	8	cloned	No	BMA0204	53725011		ABC transporter, ATP-binding/permease pr...	623	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	4AA3	32.8%	Burkholderia mallei

IDP91081 (show subtarget assignments)	8	cloned	No	CD2817	126700433		ABC transporter, ATP-binding/permease pr...	596	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3QF4	39.4%	Clostridium difficile

IDP91899 (show subtarget assignments)	8	selected	No	SpneCM_010100002520	298254473		ABC transporter, ATP-binding/permease pr...	564	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3QF4	39.1%	Streptococcus pneumoniae

IDP91900 (show subtarget assignments)	8	selected	No	SpneCM_010100003670	298254699		ABC transporter, ATP-binding/permease pr...	581	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3B5X	32.9%	Streptococcus pneumoniae

IDP91941 (show subtarget assignments)	8	selected	No	SpneCM_010100000177	298254016		ABC transporter, ATP-binding/permease pr...	588	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3QF4	38.6%	Streptococcus pneumoniae

IDP91069 (show subtarget assignments)	8	cloned	No	SP_1357	15901211		ABC transporter, ATP-binding/permease pr...	596	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3QF4	37.1%	Streptococcus pneumoniae

IDP00487 (show subtarget assignments)	1	purified	No	YPO1491	16121764		ABC transporter ATP-binding protein	531	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	24.7%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00728 (show subtarget assignments)	1	cloned	No	SACOL2210	57284991		ABC transporter, ATP-binding protein	286	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	32.2%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01159 (show subtarget assignments)	1	soluble	No	BA_4745	30259235		ABC transporter, ATP-binding protein	294	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	24.8%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP00705 (show subtarget assignments)	1	cloned	No	SACOL0306	57285419		ABC transporter, ATP-binding protein	225	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	39%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP00729 (show subtarget assignments)	1	purified	No	SACOL2356	57285089		ABC transporter, ATP-binding protein	221	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	37.1%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP00721 (show subtarget assignments)	1	expressed	No	SACOL1613	57286135		ABC transporter, ATP-binding protein	261	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	31.8%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01502 (show subtarget assignments)	1	expressed	No	VCA0977	15601730		ABC transporter, ATP-binding protein	539	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	23.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01520 (show subtarget assignments)	1	expressed	No	VCA0782	15601537		ABC transporter, ATP-binding protein	225	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	46.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01320 (show subtarget assignments)	1	purified	No	VC1883	15641885		ABC transporter, ATP-binding protein	228	Conserved Gene / Pathway	Phase 2: March 2008	2PCJ	45.6%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01490 (show subtarget assignments)	1	expressed	No	VCA0602	15601360		ABC transporter, ATP-binding protein	403	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	34%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01425 (show subtarget assignments)	1	expressed	No	VC1630	15641635		ABC transporter, ATP-binding protein	227	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	37%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01161 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4997	30259489		ABC transporter, ATP-binding protein	253	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	38.3%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01164 (show subtarget assignments)	1	purified	No	BA_5600	30260056		ABC transporter, ATP-binding protein	300	Conserved Gene / Pathway	Phase 2: March 2008	2YYZ	31.3%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP00706 (show subtarget assignments)	1	purified	No	SACOL0504	57285529		ABC transporter, ATP-binding protein	341	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	46%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP00609 (show subtarget assignments)	1	expressed	No	SACOL0690	57285660		ABC transporter, ATP-binding protein	247	Conserved Gene / Pathway	Phase 2: March 2008	3D31	29.1%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP00752 (show subtarget assignments)	1	purified	No	SACOL2211	57284992		ABC transporter, ATP-binding protein	269	Drug Target Function	Phase 2: March 2008	3GFO	37.5%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01162 (show subtarget assignments)	1	expressed	No	BA_5496	30259957		ABC transporter, ATP-binding protein	226	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	54.4%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP00704 (show subtarget assignments)	1	expressed	No	SACOL0264	57286724		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	32%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01125 (show subtarget assignments)	1	expressed	No	BA_5175	30259658		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01165 (show subtarget assignments)	1	expressed	No	BA_5650	30260099		ABC transporter, ATP-binding protein	305	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	30.8%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01470 (show subtarget assignments)	1	purified	No	VC2608	15642603		ABC transporter, ATP-binding protein	664	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	23.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01158 (show subtarget assignments)	1	expressed	No	BA_4669	30259165		ABC transporter, ATP-binding protein	258	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	38%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01424 (show subtarget assignments)	1	purified	No	VC1568	15641576		ABC transporter, ATP-binding protein	233	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	49.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP00708 (show subtarget assignments)	1	expressed	No	SACOL0779	57285742		ABC transporter, ATP-binding protein	625	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	22.2%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01464 (show subtarget assignments)	1	soluble	No	VC2520	15642516		ABC transporter, ATP-binding protein	267	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	34.5%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01156 (show subtarget assignments)	1	expressed	No	BA_0798	30254389		ABC transporter, ATP-binding protein	224	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	50.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01465 (show subtarget assignments)	1	purified	No	VC2528	15642523		ABC transporter, ATP-binding protein	241	Conserved Gene / Pathway	Phase 2: March 2008	1JI0	33.6%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP00727 (show subtarget assignments)	1	cloned	No	SACOL2036	57284905		ABC transporter, ATP-binding protein	642	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	24.1%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01331 (show subtarget assignments)	1	purified	No	VC0589	15640610		ABC transporter, ATP-binding protein	305	Conserved Gene / Pathway	Phase 2: March 2008	2PCJ	28.9%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01163 (show subtarget assignments)	1	purified	No	BA_5526	30259986		ABC transporter, ATP-binding protein	280	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	30%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP00731 (show subtarget assignments)	1	purified	No	SACOL2462	57286457		ABC transporter, ATP-binding protein	220	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	35.5%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01468 (show subtarget assignments)	1	purified	No	VC2553	15642548		ABC transporter, ATP-binding protein, au...	238	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	32.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01695 (show subtarget assignments)	1	expressed	No	GBAA0228	47525485		ABC transporter ATP-binding protein [Bac...	626	Conserved; Drug target functions	Phase 3: June 2008	1YQT	20.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02259 (show subtarget assignments)	1	cloned	No	GBAA2164	47527458		ABC transporter ATP-binding protein [Bac...	631	Conserved; Drug target functions	Phase 3: June 2008	1YQT	21.4%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01675 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5217	47530523		ABC transporter ATP-binding protein [Bac...	261	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2D2E	57.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02762 (show subtarget assignments)	1	cloned	No	GBAA2482	47527772		ABC transporter ATP-binding protein [Bac...	256	Conserved; Drug target functions	Phase 3: June 2008	1F3O	40.6%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP90824 (show subtarget assignments)	8	purified	No	Cj0774c	15792112		ABC transporter ATP-binding protein [Cam...	336	Predicted Essential	Community Requests	3DHW	38.2%	Campylobacter jejuni

IDP02756 (show subtarget assignments)	1	expressed	No	CBU_2038	29542591		ABC transporter, ATP-binding protein [Co...	240	Conserved; Drug target functions	Phase 3: June 2008	2HYD	33.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02426 (show subtarget assignments)	1	cloned	No	CBU_1952	29542507		ABC transporter, ATP-binding protein [Co...	532	Conserved; Drug target functions	Phase 3: June 2008	2IW3	26.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01601 (show subtarget assignments)	1	expressed	No	CBU_0746	29541346		ABC transporter, ATP-binding protein [Co...	249	Conserved; Drug target functions	Phase 3: June 2008	3FVQ	34.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02511 (show subtarget assignments)	1	soluble	No	CBU_1359	29541924	sufC	ABC transporter, ATP-binding protein [Co...	244	Conserved; Drug target functions	Phase 3: June 2008	2D3W	63.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02608 (show subtarget assignments)	1	expressed	No	CBU_0178	29540794		ABC transporter, ATP-binding protein [Co...	252	Conserved; Drug target functions	Phase 3: June 2008	1V43	43.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02070 (show subtarget assignments)	1	expressed	No	CBU_1809	29542365		ABC transporter, ATP-binding protein [Co...	221	Conserved; Drug target functions	Phase 3: June 2008	1F3O	49.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01758 (show subtarget assignments)	1	expressed	No	CBU_0728	29541328		ABC transporter, ATP-binding protein [Co...	268	Conserved; Drug target functions	Phase 3: June 2008	1B0U	32.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02056 (show subtarget assignments)	1	expressed	No	CBU_0934	29541521		ABC transporter, ATP-binding protein [Co...	304	Conserved; Drug target functions	Phase 3: June 2008	1VPL	27.6%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02015 (show subtarget assignments)	1	expressed	No	CBU_0107	29540727		ABC transporter, ATP-binding protein [Co...	351	Conserved; Drug target functions	Phase 3: June 2008	3DHW	49.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02431 (show subtarget assignments)	1	crystallized	No	CBU_1770	29542327		ABC transporter, ATP-binding protein [Co...	432	Conserved; Drug target functions	Phase 3: June 2008	2YYZ	23.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01660 (show subtarget assignments)	1	expressed	No	CBU_0776	29541372		ABC transporter, ATP-binding protein [Co...	283	Conserved; Drug target functions	Phase 3: June 2008	1VPL	25.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02099 (show subtarget assignments)	1	cloned	No	FTT0972	56708065		ABC transporter, ATP-binding protein [Fr...	249	Conserved; Drug target functions	Phase 3: June 2008	2D3W	57.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02457 (show subtarget assignments)	1	expressed	No	FTT1248	56708310		ABC transporter, ATP-binding protein [Fr...	253	Drug Target	Phase 3: June 2008	1B0U	31.1%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02112 (show subtarget assignments)	1	cloned	No	FTT1024c	56708113	yhbG	ABC transporter, ATP-binding protein [Fr...	243	Conserved; Drug target functions	Phase 3: June 2008	1JI0	34.6%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01607 (show subtarget assignments)	1	cloned	No	FTT1608	56708628		ABC transporter, ATP-binding protein [Fr...	267	Conserved; Drug target functions	Phase 3: June 2008	3DHW	30%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP91074 (show subtarget assignments)	8	cloned	No	MSMEG_5659	118469658		ABC transporter, ATP-binding protein [My...	610	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3QF4	32.1%	Mycobacterium smegmatis

IDP00726 (show subtarget assignments)	1	purified	No	SACOL1929	57286276		ABC transporter, ATP-binding protein, pu...	505	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP91940 (show subtarget assignments)	8	selected	No	SpneCM_010100006879	298255307		ABC transporter, ATP-binding protein [St...	538	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2HYD	25.4%	Streptococcus pneumoniae

IDP91893 (show subtarget assignments)	8	selected	No	SpneCM_010100003665	298254698		ABC transporter, ATP-binding protein [St...	580	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2HYD	34.8%	Streptococcus pneumoniae

IDP01669 (show subtarget assignments)	1	cloned	No	YPO3048	16123225		ABC transporter ATP-binding protein [Yer...	356	CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1Z47	36.8%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP91928 (show subtarget assignments)	8	selected	No	SpneCM_010100008890	298255690		ABC transporter membrane-spanning permea...	668	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP91937 (show subtarget assignments)	8	selected	No	SpneCM_010100003555	298254676		ABC transporter membrane-spanning permea...	425	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP01491 (show subtarget assignments)	1	soluble	No	VCA0603	15601361		ABC transporter, periplasmic substrate-b...	339	Conserved Gene / Pathway	Phase 2: March 2008	1Y4T	18.3%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP02622 (show subtarget assignments)	1	cloned	No	CBU_0109	29540729		ABC transporter, periplasmic substrate-b...	267	Conserved; Drug target functions	Phase 3: June 2008	3TQW	88.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP91082 (show subtarget assignments)	8	cloned	No	CPF_1776	110800219		ABC transporter, permease/ATP-binding pr...	589	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3QF4	39.2%	Clostridium perfringens

IDP04058 (show subtarget assignments)	1	soluble	No	CPF_0556	110800185		ABC transporter, solute-binding protein ...	461	drug target; putative drug target function;	Phase 4: April 2009	1EU8	18.9%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP05622 (show subtarget assignments)	1	soluble	No	CD0999	126698583		ABC transporter, substrate-binding lipop...	331	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HN0	24.2%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP05100 (show subtarget assignments)	1	soluble	No	CD0876	126698453		ABC transporter, substrate-binding lipop...	345	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3LFT	32.2%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP05195 (show subtarget assignments)	1	soluble	No	CD0873	126698450		ABC transporter, substrate-binding lipop...	340	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3LKV	32.9%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP04004
(show subtarget assignments)

1

cloned

No

CPF_1305

110799423

mtnN

5'-methylthioadenosine/S-adenosylhomocys...

266

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3EEI

34.6%

Clostridium perfringens

Central intermediary metabolism

Other

IDP90930
(show subtarget assignments)

8

cloned

No

YPO3384

16123533

mtn

5'-methylthioadenosine/S-adenosylhomocys...

233

Predicted Essential

Community Requests

1JYS

74.7%

Yersinia pestis

IDP05499
(show subtarget assignments)

1

soluble

No

BA_4322

30258823

5'-nucleotidase family protein [Bacillus...

529

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Z1A

30.2%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01184
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0267

41016866

60 kDa chaperonin (Protein Cpn60) (groEL...

544

Conserved Gene / Pathway

Phase 2: March 2008

1WE3

67.1%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP90415
(show subtarget assignments)

8

cloned

No

CT_443

3328874

omcB

60kDa Cysteine-Rich OMP [Chlamydia trach...

553

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02565
(show subtarget assignments)

1

soluble

No

CBU_0648

29541249

ribH

6,7-dimethyl-8-ribityllumazine synthase ...

151

Conserved; Drug target functions

Phase 3: June 2008

1VSW

47.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP91190
(show subtarget assignments)

1

in_crystallization_trials

No

EF_A0061

29345308

6'-aminoglycoside N-acetyltransferase [E...

479

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3R6Z

20%

Enterococcus faecalis

IDP90140
(show subtarget assignments)

8

expressed

No

MPXV_ZAI1979_005_184

68449255

6kDa intracellular viral protein [Monkey...

221

similar to VACV-COP-B9R, MPXV-ZAI96-B10R

Community Requests

Monkeypox virus

IDP02041
(show subtarget assignments)

1

in_crystallization_trials

No

STM3051

16766352

bglA

6-phospho-beta-glucosidase A [Salmonella...

477

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

2XHY

95.4%

Salmonella enterica

Energy metabolism

Other

IDP04454
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1254

218928409

bglA

6-phospho-beta-glucosidase [Yersinia pes...

478

drug target; putative drug target function;

Phase 4: April 2009

2XHY

77.8%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01635
(show subtarget assignments)

1

soluble

No

GBAA4844

47530139

pfkA

6-phosphofructokinase [Bacillus anthraci...

319

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3U39

86.5%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP91811
(show subtarget assignments)

8

soluble

No

b3916

1790350

pfkA

6-phosphofructokinase I [Escherichia col...

320

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1PFK

100%

Escherichia coli

IDP91827
(show subtarget assignments)

8

soluble

No

b1723

1788017

pfkB

6-phosphofructokinase II [Escherichia co...

309

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

3CQD

100%

Escherichia coli

IDP90255
(show subtarget assignments)

8

purified

No

SAR1777

49483940

pfkA

6-phosphofructokinase [Staphylococcus au...

322

(From requester) Identified as potential drug target for S. aureus MRSA. Am curr...

Community Requests

3U39

59.3%

Staphylococcus aureus

IDP02226
(show subtarget assignments)

1

crystallized

No

GBAA0164

47525422

yqjI

6-phosphogluconate dehydrogenase [Bacill...

469

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2W8Z

72.3%

Bacillus anthracis

Energy metabolism

Pentose phosphate pathway

IDP00329
(show subtarget assignments)

1

cloned

No

Cj1724c

15793027

7-cyano-7-deazaguanine reductase

127

Drug Target Function

Phase 2: March 2008

Campylobacter jejuni

Amino acid biosynthesis

Pyruvate family

IDP04629
(show subtarget assignments)

1

soluble

No

CBU_0151

29653509

queF

7-cyano-7-deazaguanine reductase [Coxiel...

278

drug target; conserved gene;

Phase 4: April 2009

3BP1

51.4%

Coxiella burnetii

Hypothetical proteins

Conserved

IDP01680
(show subtarget assignments)

0

work_stopped

No

VC0902

161582018

queF

7-cyano-7-deazaguanine reductase [Vibrio...

281

Conserved; Drug target homolg; Drug target functions

Phase 3: June 2008

3BP1

100%

Vibrio cholerae

N/A

IDP00937
(show subtarget assignments)

1

cloned

No

STM0795

16764158

bioF

8-amino-7-oxononanoate synthase

385

Conserved Gene / Pathway

Phase 2: March 2008

1BS0

80%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04426
(show subtarget assignments)

1

expressed

No

GBAA4339

47529636

bioF

8-amino-7-oxononanoate synthase [Bacillu...

395

putative drug target function;

Phase 4: April 2009

3A2B

33.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02629
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1006

29541588

bioF

8-amino-7-oxononanoate synthase [Coxiell...

384

Conserved; Drug target functions

Phase 3: June 2008

1BS0

37.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01953
(show subtarget assignments)

1

soluble

No

FTT0936c

56708033

bioF

8-amino-7-oxononanoate synthase [Francis...

375

Conserved; Drug target functions

Phase 3: June 2008

1BS0

32%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP90423
(show subtarget assignments)

8

cloned

No

CT_444

3328876

omcA

9kDa-Cysteine-Rich Lipoprotein [Chlamydi...

88

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP91869
(show subtarget assignments)

8

in_pdb
4E8O

No

AAC41391

547387

aac(6')-Ih

aac(6')-Ih [Acinetobacter baumannii]

146

drug resistance / confers resistance to aminoglycoside antibiotics by acetylation

Community Requests

4E8O

100%

Acinetobacter baumannii

IDP91330
(show subtarget assignments)

8

soluble

No

VV2_0263

27366712

ABC transporter ATPase [Vibrio vulnificu...

551

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91078
(show subtarget assignments)

8

cloned

No

CBU_0856

29541449

ABC transporter, ATP-binding/permease pr...

596

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5X

42.3%

Coxiella burnetii

IDP91084
(show subtarget assignments)

8

cloned

No

BA_2444

30262443

ABC transporter, ATP-binding/permease pr...

598

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3QF4

44.5%

Bacillus anthracis

IDP91083
(show subtarget assignments)

8

cloned

No

BA_0528

30260686

ABC transporter, ATP-binding/permease pr...

586

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

2HYD

58.2%

Bacillus anthracis

IDP91079
(show subtarget assignments)

8

cloned

No

BMA0204

53725011

ABC transporter, ATP-binding/permease pr...

623

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

4AA3

32.8%

Burkholderia mallei

IDP91081
(show subtarget assignments)

8

cloned

No

CD2817

126700433

ABC transporter, ATP-binding/permease pr...

596

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3QF4

39.4%

Clostridium difficile

IDP91899
(show subtarget assignments)

8

selected

No

SpneCM_010100002520

298254473

ABC transporter, ATP-binding/permease pr...

564

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3QF4

39.1%

Streptococcus pneumoniae

IDP91900
(show subtarget assignments)

8

selected

No

SpneCM_010100003670

298254699

ABC transporter, ATP-binding/permease pr...

581

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3B5X

32.9%

Streptococcus pneumoniae

IDP91941
(show subtarget assignments)

8

selected

No

SpneCM_010100000177

298254016

ABC transporter, ATP-binding/permease pr...

588

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3QF4

38.6%

Streptococcus pneumoniae

IDP91069
(show subtarget assignments)

8

cloned

No

SP_1357

15901211

ABC transporter, ATP-binding/permease pr...

596

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3QF4

37.1%

Streptococcus pneumoniae

IDP00487
(show subtarget assignments)

1

purified

No

YPO1491

16121764

ABC transporter ATP-binding protein

531

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

24.7%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00728
(show subtarget assignments)

1

cloned

No

SACOL2210

57284991

ABC transporter, ATP-binding protein

286

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

32.2%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01159
(show subtarget assignments)

1

soluble

No

BA_4745

30259235

ABC transporter, ATP-binding protein

294

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

24.8%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP00705
(show subtarget assignments)

1

cloned

No

SACOL0306

57285419

ABC transporter, ATP-binding protein

225

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

39%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP00729
(show subtarget assignments)

1

purified

No

SACOL2356

57285089

ABC transporter, ATP-binding protein

221

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

37.1%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP00721
(show subtarget assignments)

1

expressed

No

SACOL1613

57286135

ABC transporter, ATP-binding protein

261

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

31.8%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01502
(show subtarget assignments)

1

expressed

No

VCA0977

15601730

ABC transporter, ATP-binding protein

539

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

23.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01520
(show subtarget assignments)

1

expressed

No

VCA0782

15601537

ABC transporter, ATP-binding protein

225

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

46.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01320
(show subtarget assignments)

1

purified

No

VC1883

15641885

ABC transporter, ATP-binding protein

228

Conserved Gene / Pathway

Phase 2: March 2008

2PCJ

45.6%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01490
(show subtarget assignments)

1

expressed

No

VCA0602

15601360

ABC transporter, ATP-binding protein

403

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

34%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01425
(show subtarget assignments)

1

expressed

No

VC1630

15641635

ABC transporter, ATP-binding protein

227

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

37%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01161
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4997

30259489

ABC transporter, ATP-binding protein

253

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

38.3%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01164
(show subtarget assignments)

1

purified

No

BA_5600

30260056

ABC transporter, ATP-binding protein

300

Conserved Gene / Pathway

Phase 2: March 2008

2YYZ

31.3%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP00706
(show subtarget assignments)

1

purified

No

SACOL0504

57285529

ABC transporter, ATP-binding protein

341

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

46%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP00609
(show subtarget assignments)

1

expressed

No

SACOL0690

57285660

ABC transporter, ATP-binding protein

247

Conserved Gene / Pathway

Phase 2: March 2008

3D31

29.1%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP00752
(show subtarget assignments)

1

purified

No

SACOL2211

57284992

ABC transporter, ATP-binding protein

269

Drug Target Function

Phase 2: March 2008

3GFO

37.5%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01162
(show subtarget assignments)

1

expressed

No

BA_5496

30259957

ABC transporter, ATP-binding protein

226

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

54.4%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP00704
(show subtarget assignments)

1

expressed

No

SACOL0264

57286724

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

32%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01125
(show subtarget assignments)

1

expressed

No

BA_5175

30259658

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01165
(show subtarget assignments)

1

expressed

No

BA_5650

30260099

ABC transporter, ATP-binding protein

305

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

30.8%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01470
(show subtarget assignments)

1

purified

No

VC2608

15642603

ABC transporter, ATP-binding protein

664

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

23.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01158
(show subtarget assignments)

1

expressed

No

BA_4669

30259165

ABC transporter, ATP-binding protein

258

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

38%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01424
(show subtarget assignments)

1

purified

No

VC1568

15641576

ABC transporter, ATP-binding protein

233

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

49.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP00708
(show subtarget assignments)

1

expressed

No

SACOL0779

57285742

ABC transporter, ATP-binding protein

625

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

22.2%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01464
(show subtarget assignments)

1

soluble

No

VC2520

15642516

ABC transporter, ATP-binding protein

267

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

34.5%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01156
(show subtarget assignments)

1

expressed

No

BA_0798

30254389

ABC transporter, ATP-binding protein

224

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

50.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01465
(show subtarget assignments)

1

purified

No

VC2528

15642523

ABC transporter, ATP-binding protein

241

Conserved Gene / Pathway

Phase 2: March 2008

1JI0

33.6%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP00727
(show subtarget assignments)

1

cloned

No

SACOL2036

57284905

ABC transporter, ATP-binding protein

642

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

24.1%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01331
(show subtarget assignments)

1

purified

No

VC0589

15640610

ABC transporter, ATP-binding protein

305

Conserved Gene / Pathway

Phase 2: March 2008

2PCJ

28.9%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01163
(show subtarget assignments)

1

purified

No

BA_5526

30259986

ABC transporter, ATP-binding protein

280

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

30%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP00731
(show subtarget assignments)

1

purified

No

SACOL2462

57286457

ABC transporter, ATP-binding protein

220

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

35.5%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01468
(show subtarget assignments)

1

purified

No

VC2553

15642548

ABC transporter, ATP-binding protein, au...

238

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

32.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01695
(show subtarget assignments)

1

expressed

No

GBAA0228

47525485

ABC transporter ATP-binding protein [Bac...

626

Conserved; Drug target functions

Phase 3: June 2008

1YQT

20.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02259
(show subtarget assignments)

1

cloned

No

GBAA2164

47527458

ABC transporter ATP-binding protein [Bac...

631

Conserved; Drug target functions

Phase 3: June 2008

1YQT

21.4%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01675
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5217

47530523

ABC transporter ATP-binding protein [Bac...

261

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2D2E

57.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02762
(show subtarget assignments)

1

cloned

No

GBAA2482

47527772

ABC transporter ATP-binding protein [Bac...

256

Conserved; Drug target functions

Phase 3: June 2008

1F3O

40.6%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP90824
(show subtarget assignments)

8

purified

No

Cj0774c

15792112

ABC transporter ATP-binding protein [Cam...

336

Predicted Essential

Community Requests

3DHW

38.2%

Campylobacter jejuni

IDP02756
(show subtarget assignments)

1

expressed

No

CBU_2038

29542591

ABC transporter, ATP-binding protein [Co...

240

Conserved; Drug target functions

Phase 3: June 2008

2HYD

33.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02426
(show subtarget assignments)

1

cloned

No

CBU_1952

29542507

ABC transporter, ATP-binding protein [Co...

532

Conserved; Drug target functions

Phase 3: June 2008

2IW3

26.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01601
(show subtarget assignments)

1

expressed

No

CBU_0746

29541346

ABC transporter, ATP-binding protein [Co...

249

Conserved; Drug target functions

Phase 3: June 2008

3FVQ

34.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02511
(show subtarget assignments)

1

soluble

No

CBU_1359

29541924

sufC

ABC transporter, ATP-binding protein [Co...

244

Conserved; Drug target functions

Phase 3: June 2008

2D3W

63.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02608
(show subtarget assignments)

1

expressed

No

CBU_0178

29540794

ABC transporter, ATP-binding protein [Co...

252

Conserved; Drug target functions

Phase 3: June 2008

1V43

43.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02070
(show subtarget assignments)

1

expressed

No

CBU_1809

29542365

ABC transporter, ATP-binding protein [Co...

221

Conserved; Drug target functions

Phase 3: June 2008

1F3O

49.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01758
(show subtarget assignments)

1

expressed

No

CBU_0728

29541328

ABC transporter, ATP-binding protein [Co...

268

Conserved; Drug target functions

Phase 3: June 2008

1B0U

32.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02056
(show subtarget assignments)

1

expressed

No

CBU_0934

29541521

ABC transporter, ATP-binding protein [Co...

304

Conserved; Drug target functions

Phase 3: June 2008

1VPL

27.6%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02015
(show subtarget assignments)

1

expressed

No

CBU_0107

29540727

ABC transporter, ATP-binding protein [Co...

351

Conserved; Drug target functions

Phase 3: June 2008

3DHW

49.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02431
(show subtarget assignments)

1

crystallized

No

CBU_1770

29542327

ABC transporter, ATP-binding protein [Co...

432

Conserved; Drug target functions

Phase 3: June 2008

2YYZ

23.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01660
(show subtarget assignments)

1

expressed

No

CBU_0776

29541372

ABC transporter, ATP-binding protein [Co...

283

Conserved; Drug target functions

Phase 3: June 2008

1VPL

25.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02099
(show subtarget assignments)

1

cloned

No

FTT0972

56708065

ABC transporter, ATP-binding protein [Fr...

249

Conserved; Drug target functions

Phase 3: June 2008

2D3W

57.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02457
(show subtarget assignments)

1

expressed

No

FTT1248

56708310

ABC transporter, ATP-binding protein [Fr...

253

Drug Target

Phase 3: June 2008

1B0U

31.1%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02112
(show subtarget assignments)

1

cloned

No

FTT1024c

56708113

yhbG

ABC transporter, ATP-binding protein [Fr...

243

Conserved; Drug target functions

Phase 3: June 2008

1JI0

34.6%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01607
(show subtarget assignments)

1

cloned

No

FTT1608

56708628

ABC transporter, ATP-binding protein [Fr...

267

Conserved; Drug target functions

Phase 3: June 2008

3DHW

30%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP91074
(show subtarget assignments)

8

cloned

No

MSMEG_5659

118469658

ABC transporter, ATP-binding protein [My...

610

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3QF4

32.1%

Mycobacterium smegmatis

IDP00726
(show subtarget assignments)

1

purified

No

SACOL1929

57286276

ABC transporter, ATP-binding protein, pu...

505

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP91940
(show subtarget assignments)

8

selected

No

SpneCM_010100006879

298255307

ABC transporter, ATP-binding protein [St...

538

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2HYD

25.4%

Streptococcus pneumoniae

IDP91893
(show subtarget assignments)

8

selected

No

SpneCM_010100003665

298254698

ABC transporter, ATP-binding protein [St...

580

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2HYD

34.8%

Streptococcus pneumoniae

IDP01669
(show subtarget assignments)

1

cloned

No

YPO3048

16123225

ABC transporter ATP-binding protein [Yer...

356

CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1Z47

36.8%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP91928
(show subtarget assignments)

8

selected

No

SpneCM_010100008890

298255690

ABC transporter membrane-spanning permea...

668

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP91937
(show subtarget assignments)

8

selected

No

SpneCM_010100003555

298254676

ABC transporter membrane-spanning permea...

425

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP01491
(show subtarget assignments)

1

soluble

No

VCA0603

15601361

ABC transporter, periplasmic substrate-b...

339

Conserved Gene / Pathway

Phase 2: March 2008

1Y4T

18.3%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP02622
(show subtarget assignments)

1

cloned

No

CBU_0109

29540729

ABC transporter, periplasmic substrate-b...

267

Conserved; Drug target functions

Phase 3: June 2008

3TQW

88.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP91082
(show subtarget assignments)

8

cloned

No

CPF_1776

110800219

ABC transporter, permease/ATP-binding pr...

589

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3QF4

39.2%

Clostridium perfringens

IDP04058
(show subtarget assignments)

1

soluble

No

CPF_0556

110800185

ABC transporter, solute-binding protein ...

461

drug target; putative drug target function;

Phase 4: April 2009

1EU8

18.9%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP05622
(show subtarget assignments)

1

soluble

No

CD0999

126698583

ABC transporter, substrate-binding lipop...

331

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HN0

24.2%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP05100
(show subtarget assignments)

1

soluble

No

CD0876

126698453

ABC transporter, substrate-binding lipop...

345

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3LFT

32.2%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP05195
(show subtarget assignments)

1

soluble

No

CD0873

126698450

ABC transporter, substrate-binding lipop...

340

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3LKV

32.9%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines