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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 4 of 60, showing 100 records out of 5973 total, starting on record 301
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP00263
(
show subtarget assignments
)
1
cloned
No
AF180817_1-114
7329982
N/A
Capsid protein (C)
114
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
60.5%
Dengue virus
Unclassified
N/A
IDP91778
(
show subtarget assignments
)
8
in_crystallization_trials
No
AF132548_1
7380949
vanXYc
D,D-dipeptidase/D,D-carboxypeptidase Van...
190
drug resistance /
Gene vanXYC encodes D,D -dipeptidase (VanX) and D,D-carboxypeptidase (VanY) acti...
Community Requests
Enterococcus gallinarum
IDP91877
(
show subtarget assignments
)
8
selected
No
CAB89086
7649401
fox-4
beta-lactamase class C [Escherichia coli...
382
potential drug target /
Dissemination of plasmid-mediated class C ?-lactamases is currently a critical c...
Community Requests
1ZKJ
71.7%
Escherichia coli
IDP91717
(
show subtarget assignments
)
8
selected
No
NP_054706
7669550
VCL
vinculin isoform meta-VCL [Homo sapiens]...
1134
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1TR2
94%
Homo sapiens
IDP91677
(
show subtarget assignments
)
8
selected
No
FLUAVs7gp1
8486123
M1
matrix protein 1 [Influenza A virus (A/P...
252
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1EA3
65.1%
Influenza A
IDP91171
(
show subtarget assignments
)
8
expressed
No
CT_370
9087121
RecName: Full=Shikimate biosynthesis pro...
478
potential drug target /
Shikimate pathway enzyme
Community Requests
2EGG
18.2%
Chlamydia trachomatis
IDP00255
(
show subtarget assignments
)
1
selected
No
NP_041725:276-677
9627243
CFA
Cell fusing agent virus Envelope protein...
402
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
3C5X
15.2%
Cell fusing
IDP00253
(
show subtarget assignments
)
1
in_crystallization_trials
No
YFVgp1
9627245
Yellow fever virus Envelope protein
399
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
1P58
43.8%
Yellow fever
IDP91682
(
show subtarget assignments
)
8
selected
No
MuHV4gp74
9629629
ORF73
nuclear antigen LANA [Murid herpesvirus ...
314
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1I3Q
13.1%
Murid herpesvirus
IDP00251
(
show subtarget assignments
)
1
cloned
No
MVEVgp1
9633623
Murray Valley encephalitis Envelope prot...
407
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
3P54
78.1%
Murray Valley
IDP90214
(
show subtarget assignments
)
8
expressed
No
MYXV_gp017
9633649
m013L
m013L, M013L
126
interferon inducible protein
Community Requests
Myxoma virus
unknown
0
IDP90213
(
show subtarget assignments
)
8
purified
No
MYXV_gp033
9633665
m029L
m029L, m29L
115
IFN resistance, PKR inhibitor
Community Requests
2YT4
19.1%
Myxoma virus
host range factor, host defense modulator
0
IDP90212
(
show subtarget assignments
)
8
cloned
No
MYXV_gp067
9633699
m063R
m063R, m63R
215
CD47-likeÂ
Community Requests
Myxoma virus
host range factor, host defense modulator
0
IDP90211
(
show subtarget assignments
)
8
cloned
No
MYXV_gp132
9633764
m128L
m128L
281
integrin-associated protein homolog similar to VACV-Cop:A38L. Five pass TM prote...
Community Requests
Myxoma virus
host defense modulator
0
IDP90210
(
show subtarget assignments
)
8
expressed
No
MYXV_gp140
9633772
m136R
m136R
179
unknown, similar to VACV-Cop:A52R
Community Requests
2VVW
20.1%
Myxoma virus
unknown, conserved protein
0
IDP90208
(
show subtarget assignments
)
8
expressed
No
MYXV_gp143
9633775
m139R
m139R
188
Intracellular TLR and IL-1 signaling inhibitor, similar to VACV-Cop:A52R
Community Requests
2VVW
32.4%
Myxoma virus
host defense modulator
0
IDP90209
(
show subtarget assignments
)
8
expressed
No
MYXV_gp144
9633776
m140R
m140R
553
kelch motif, similar to VACV-Cop:A55R
Community Requests
1U6D
14.3%
Myxoma virus
unknown, conserved protein
0
IDP90206
(
show subtarget assignments
)
8
soluble
No
MYXV_gp149
9633781
m146R
m146R
108
virokine/NFkB inh/Str resemblence to apoptotic reg, similar to VACV-Cop:N1L
Community Requests
2I39
26.9%
Myxoma virus
host defense modulator
0
IDP90218
(
show subtarget assignments
)
8
soluble
No
MYXV_gp151
9633783
m148R
m148R
675
ankyrin motif, similar to VACV-Cop:B4R
Community Requests
2J8S
6.1%
Myxoma virus
host range factor
0
IDP90207
(
show subtarget assignments
)
8
soluble
No
MYXV_gp152
9633784
m149R
m149R
490
ankyrin motif, similar to VACV-Cop:B4R
Community Requests
1N11
14.9%
Myxoma virus
host range factor
0
IDP90220
(
show subtarget assignments
)
8
selected
No
MYXV_gp153
9633785
m150R
m150R
494
ankyrin-like protein, myxoma nuclear factor
Community Requests
Myxoma virus
host range factor
0
IDP90221
(
show subtarget assignments
)
8
cloned
No
MYXV_gp157
9633790
m154L
m154L, gp120-like
214
NFkB inhibitor, similar to VACV-Cop:M2L
Community Requests
Myxoma virus
host defense modulator
0
IDP90217
(
show subtarget assignments
)
8
soluble
No
MYXV_gp004
9633795
m003.1L
m003.1L, m3.1
151
similar to VACV-Cop:B22R, member of Poxvirus A4/B15 family. This is a family of ...
Community Requests
2VVY
29.8%
Myxoma virus
unknown
0
IDP90216
(
show subtarget assignments
)
8
expressed
No
MYXV_gp008
9633799
m005L
m005L, m5, M-T5
483
ankyrin motif, similar to VACV-Cop:B4R. Possible apoptosis regulator.
Community Requests
1N0R
8.5%
Myxoma virus
host range factor, host defense modulator
0
IDP90215
(
show subtarget assignments
)
8
expressed
No
MYXV_gp009
9633800
m006L
m006L, m6
509
contains kelch motifs, similar to MYX-L-m006R
Community Requests
1X2J
13.9%
Myxoma virus
unknown
0
IDP90219
(
show subtarget assignments
)
8
expressed
No
MYXV_gp011
9633802
m008L
m008L, m8
515
contains kelch motifs, similar to MYX-L-m006R
Community Requests
2XN4
11.5%
Myxoma virus
unknown
0
IDP00132
(
show subtarget assignments
)
1
purified
No
VC_0288
9654699
VC0288
Vibrio cholerae O1 biovar eltor str. N16...
618
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2GP4
53.9%
Vibrio cholerae
Energy metabolism
Entner-Doudoroff
IDP00114
(
show subtarget assignments
)
1
purified
No
GVCV52ORF0478
9654887
Vibrio cholerae O1 biovar eltor str. N16...
345
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3JVU
65.8%
Vibrio cholerae
Cell envelope
Surface structures
IDP05770
(
show subtarget assignments
)
1
cloned
No
VC_0465
9654891
tyrosyl-tRNA synthetase [Vibrio cholerae...
434
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2TS1
50%
Vibrio cholerae
Protein synthesis: tRNA aminoacylation
IDP04155
(
show subtarget assignments
)
1
cloned
No
VC0547
9654975
aspartokinase, alpha and beta subunits [...
395
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3L76
39.8%
Vibrio cholerae
Amino acid biosynthesis
Aspartate family
IDP05224
(
show subtarget assignments
)
1
cloned
No
VC_0595
9655026
glutamyl-tRNA synthetase-related protein...
304
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1NZJ
55.3%
Vibrio cholerae
Unknown function: General
IDP05300
(
show subtarget assignments
)
1
cloned
No
VC_0631
9655066
tyrosyl-tRNA synthetase [Vibrio cholerae...
395
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1H3E
47.8%
Vibrio cholerae
Protein synthesis: tRNA aminoacylation
IDP04156
(
show subtarget assignments
)
1
expressed
No
VC0681
9655120
riboflavin kinase/FMN adenylyltransferas...
322
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1MRZ
32.3%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Riboflavin, FMN, and FAD
IDP04497
(
show subtarget assignments
)
1
soluble
No
VC0768
9655215
GMP synthase [Vibrio cholerae O1 biovar ...
517
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1GPM
80.8%
Vibrio cholerae
Purines, pyrimidines, nucleosides, and nucleotides
Purine ribonucleotide biosynthesis
IDP01750
(
show subtarget assignments
)
1
in_pdb
3RJ4
3UXJ
3RZQ
3RZP
3S19
3UXV
3RJB
No
VC_0902
9655358
Vibrio cholerae O1 biovar eltor str. N16...
287
DRUG TARGET HOMOLOG
Phase 3: June 2008
3BP1
100%
Vibrio cholerae
N/A
N/A
IDP00137
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC_0959
9655418
VC0959
Vibrio cholerae O1 biovar eltor str. N16...
291
Virulence
Phase 1: October 2007
3NQR
29.6%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP04501
(
show subtarget assignments
)
1
cloned
No
VC0991
9655452
asparagine synthetase B, glutamine-hydro...
554
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1CT9
75.3%
Vibrio cholerae
Amino acid biosynthesis
Aspartate family
IDP04099
(
show subtarget assignments
)
1
expressed
No
VC1027
9655490
molybdenum cofactor biosynthesis protein...
81
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1FM0
70.4%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Molybdopterin
IDP04410
(
show subtarget assignments
)
1
cloned
No
VC1047
9655512
fatty oxidation complex, alpha subunit [...
724
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1WDK
36.4%
Vibrio cholerae
Fatty acid and phospholipid metabolism
Degradation
IDP04502
(
show subtarget assignments
)
1
purified
No
VC1136
9655608
amidotransferase HisH [Vibrio cholerae O...
203
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1KA9
36.9%
Vibrio cholerae
Amino acid biosynthesis
Histidine family
IDP04160
(
show subtarget assignments
)
1
in_pdb
3NAV
No
VC1169
9655645
tryptophan synthase, alpha subunit [Vibr...
268
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3NAV
100%
Vibrio cholerae
Amino acid biosynthesis
Aromatic amino acid family
IDP04161
(
show subtarget assignments
)
1
cloned
No
VC1172
9655648
anthranilate phosphoribosyltransferase [...
353
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1KGZ
59.5%
Vibrio cholerae
Amino acid biosynthesis
Aromatic amino acid family
IDP91529
(
show subtarget assignments
)
8
soluble
No
VC_1312
9655801
alanine racemase, putative [Vibrio chole...
428
other biological interest /
The protein we are submitting is a broad spectrum amino acid racemase (Lam et al...
Community Requests
4ECL
24.8%
Vibrio cholerae
IDP04059
(
show subtarget assignments
)
1
expressed
No
VC1973
9656513
naphthoate synthase [Vibrio cholerae O1 ...
296
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3H02
80.7%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Menaquinone and ubiquinone
IDP04167
(
show subtarget assignments
)
1
cloned
No
VC1977
9656518
aspartate aminotransferase, putative [Vi...
404
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1XI9
40.8%
Vibrio cholerae
Amino acid biosynthesis
Aspartate family
IDP00133
(
show subtarget assignments
)
1
purified
No
VC_2095
9656644
VC2095
Vibrio cholerae O1 biovar eltor str. N16...
548
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2FUV
70.3%
Vibrio cholerae
Energy metabolism
Sugars
IDP00134
(
show subtarget assignments
)
1
purified
No
VC_2250
9656811
VC2250
Vibrio cholerae O1 biovar eltor str. N16...
351
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3EH0
63%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP04172
(
show subtarget assignments
)
1
purified
No
VC2268
9656830
riboflavin synthase, beta subunit [Vibri...
173
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3MK3
56.6%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Riboflavin, FMN, and FAD
IDP90226
(
show subtarget assignments
)
1
selected
No
VC2428
9657003
conserved hypothetical protein [Vibrio c...
246
Conserved gene clusters with virulence associated genes. Conserved Protein; Pred...
January 2009
2OEZ
74.8%
Vibrio cholerae
IDP04543
(
show subtarget assignments
)
1
expressed
No
VC2453
9657030
sensor histidine kinase/response regulat...
927
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
8.1%
Vibrio cholerae
Regulatory functions
Other
IDP04333
(
show subtarget assignments
)
1
cloned
No
VC2483
9657062
acetolactate synthase III, large subunit...
573
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1JSC
42.8%
Vibrio cholerae
Amino acid biosynthesis
Pyruvate family
IDP04175
(
show subtarget assignments
)
1
purified
No
VC2511
9657094
aspartate carbamoyltransferase, regulato...
155
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1D09
63.2%
Vibrio cholerae
Purines, pyrimidines, nucleosides, and nucleotides
Pyrimidine ribonucleotide biosynthesis
IDP04177
(
show subtarget assignments
)
1
crystallized
No
VC2629
9657219
shikimate kinase [Vibrio cholerae O1 bio...
174
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1KAG
81%
Vibrio cholerae
Amino acid biosynthesis
Aromatic amino acid family
IDP04544
(
show subtarget assignments
)
1
cloned
No
VC2713
9657310
osmolarity sensor protein EnvZ [Vibrio c...
438
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1BXD
16.7%
Vibrio cholerae
Regulatory functions
Other
IDP04181
(
show subtarget assignments
)
1
crystallized
No
VCA0197
9657589
GMP reductase [Vibrio cholerae O1 biovar...
347
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2A7R
63.4%
Vibrio cholerae
Purines, pyrimidines, nucleosides, and nucleotides
Nucleotide and nucleoside interconversions
IDP04062
(
show subtarget assignments
)
1
in_crystallization_trials
No
VCA0637
9658051
oxygen-insensitive NAD(P)H nitroreductas...
217
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3HZN
59.4%
Vibrio cholerae
Central intermediary metabolism
Other
IDP04186
(
show subtarget assignments
)
1
cloned
No
VCA0709
9658128
sensor protein TorS [Vibrio cholerae O1 ...
1020
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3I9Y
17.1%
Vibrio cholerae
Regulatory functions
Other
IDP01616
(
show subtarget assignments
)
1
in_pdb
3EG7
No
VC_A0947
9658384
spermidine n1-acetyltransferase [Vibrio ...
173
CONSERVED
Phase 3: June 2008
3EG7
100%
Vibrio cholerae
N/A
N/A
IDP04507
(
show subtarget assignments
)
1
crystallized
No
VCA1079
9658525
pyridoxamine 5`-phosphate oxidase [Vibri...
211
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1G76
65.9%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Pyridoxine
IDP91187
(
show subtarget assignments
)
1
in_pdb
3UZR
4DCA
Yes
AF207840_1
10130002
aph(2')-Ib
aminoglycoside phosphotransferase [Enter...
299
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3HAM
100%
Enterococcus faecium
IDP91809
(
show subtarget assignments
)
8
selected
No
ZEBOVgp2
10313992
VP35
VP35 [Zaire ebolavirus]
340
Justification: Zaire ebolavirus belongs to the Filoviruses genus, on which struc...
Community Requests
3KS4
40.3%
Zaire ebolavirus
IDP91698
(
show subtarget assignments
)
8
selected
No
NP_002511
10835063
NPM1
nucleophosmin isoform 1 [Homo sapiens]
294
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2P1B
39.1%
Homo sapiens
IDP91688
(
show subtarget assignments
)
8
selected
No
NP_000565
10835143
CD55
complement decay-accelerating factor iso...
381
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3IYP
99.7%
Homo sapiens
IDP91719
(
show subtarget assignments
)
8
selected
No
NP_066925
10863909
SPINT2
kunitz-type protease inhibitor 2 isoform...
252
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2ODY
21%
Homo sapiens
IDP91701
(
show subtarget assignments
)
8
selected
No
NP_003053
11321571
SLIT3
slit homolog 3 protein precursor [Homo s...
1523
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2A0Z
11.2%
Homo sapiens
IDP92552
(
show subtarget assignments
)
8
selected
No
NP_071445
11545912
NOD2
nucleotide-binding oligomerization domai...
1040
innate immunity /
JUSTIFICATION:NOD2 is a cytoplasmic protein containing 1040 residus and three fu...
Community Requests
1DFJ
9%
Homo sapiens
IDP91165
(
show subtarget assignments
)
8
cloned
No
VC_2116
12229712
aroC
RecName: Full=Chorismate synthase; AltNa...
361
potential drug target /
Shikimate pathway enzyme
Community Requests
1R52
46.1%
Vibrio cholerae
IDP04538
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05770
12329039
ospB
OspB, protein secreted by the Mxi-Spa se...
288
Shigella effector protein
Community Requests
Shigella flexneri
IDP04539
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05775
12329044
ospD1
OspD1, secreted by the Mxi-Spa secretion...
225
Shigella effector protein
Community Requests
Shigella flexneri
IDP04537
(
show subtarget assignments
)
8
selected
No
CAC05780
12329049
virF
VirF, member of the AraC family of trans...
262
Shigella effector protein
Community Requests
3GBG
26.3%
Shigella flexneri
IDP04414
(
show subtarget assignments
)
8
selected
No
CAC05786
12329055
sepA
SepA, extracellular serine protease of t...
1364
Shigella effector protein
Community Requests
1WXR
34.9%
Shigella flexneri
IDP04336
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05790
12329059
ospC1
OspC1, secreted by the Mxi-Spa secretion...
470
Shigella effector protein
Community Requests
Shigella flexneri
IDP04381
(
show subtarget assignments
)
8
selected
No
CAC05791
12329060
unnamed protein product [Shigella flexne...
296
Shigella effector protein
Community Requests
3MKL
8.4%
Shigella flexneri
IDP04326
(
show subtarget assignments
)
8
purified
No
CAC05800
12329069
ipaA
IpaA, secreted by the Mxi-Spa machinery,...
633
Shigella effector protein
Community Requests
2FM8
10.7%
Shigella flexneri
IDP04224
(
show subtarget assignments
)
8
selected
No
CAC05802
12329071
ipaC
IpaC, secreted by the Mxi-Spa secretion ...
363
Shigella effector protein
Community Requests
Shigella flexneri
IDP04225
(
show subtarget assignments
)
8
cloned
No
CAC05803
12329072
ipaB
IpaB, secreted by the Mxi-Spa secretion ...
580
Shigella effector protein
Community Requests
3U0C
34.3%
Shigella flexneri
IDP04002
(
show subtarget assignments
)
8
selected
No
CAC05806
12329075
ipgA
IpgA, similarities to IpgE, putative cha...
129
Shigella effector protein
Community Requests
Shigella flexneri
IDP04075
(
show subtarget assignments
)
8
selected
No
CAC05807
12329076
icsB
IcsB, function unknown [Shigella flexner...
494
Shigella effector protein
Community Requests
Shigella flexneri
IDP04223
(
show subtarget assignments
)
8
selected
No
CAC05808
12329077
ipgD
IpgD, secreted by the Mxi-Spa machinery,...
538
Shigella effector protein
Community Requests
Shigella flexneri
IDP04306
(
show subtarget assignments
)
8
selected
No
CAC05809
12329078
ipgE
IpgE, cytoplasmic chaperone for IpgD [Sh...
120
Shigella effector protein
Community Requests
1K3S
27.5%
Shigella flexneri
IDP04558
(
show subtarget assignments
)
8
selected
No
CAC05811
12329080
mxiG
MxiG, component of the Mxi-Spa secretion...
371
Shigella effector protein
Community Requests
4A4Y
34%
Shigella flexneri
IDP04060
(
show subtarget assignments
)
8
selected
No
CAC05813
12329082
mxiI
MxiI, component of the Mxi-Spa secretion...
97
Shigella effector protein
Community Requests
Shigella flexneri
IDP04534
(
show subtarget assignments
)
8
selected
No
CAC05815
12329084
mxiK
MxiK, putative component of the Mxi-Spa ...
175
Shigella effector protein
Community Requests
Shigella flexneri
IDP04535
(
show subtarget assignments
)
8
selected
No
CAC05816
12329085
mxiN
MxiN, putative component of the Mxi-Spa ...
231
Shigella effector protein
Community Requests
Shigella flexneri
IDP04066
(
show subtarget assignments
)
8
selected
No
CAC05819
12329088
mxiE
MxiE, similarities to transcriptional ac...
210
Shigella effector protein
Community Requests
Shigella flexneri
IDP04117
(
show subtarget assignments
)
8
selected
No
CAC05825
12329094
spa13
spa13, component of the Mxi-Spa secretio...
112
Shigella effector protein
Community Requests
Shigella flexneri
IDP04536
(
show subtarget assignments
)
8
selected
No
CAC05826
12329095
spa32
Spa32, secreted by and component of the ...
292
Shigella effector protein
Community Requests
Shigella flexneri
IDP04222
(
show subtarget assignments
)
8
selected
No
CAC05827
12329096
spa33
Spa33, component of the Mxi-Spa secretio...
293
Shigella effector protein
Community Requests
Shigella flexneri
IDP04415
(
show subtarget assignments
)
8
selected
No
CAC05837
12329106
icsA (virG)
IcsA (VirG), outermembrane protein expos...
1102
Shigella effector protein
Community Requests
3ML3
15.2%
Shigella flexneri
IDP04559
(
show subtarget assignments
)
8
selected
No
CAC05871
12329140
ospE1
OspE1, secreted by the Mxi-Spa secretion...
88
Shigella effector protein
Community Requests
Shigella flexneri
IDP05771
(
show subtarget assignments
)
1
cloned
No
Z0339
12513053
alpha replication protein of prophage CP...
777
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1KA8
9.5%
Escherichia coli
Mobile and extrachromosomal element functions: Prophage functions
IDP05585
(
show subtarget assignments
)
1
soluble
No
Z0801
12513558
ybeK
putative tRNA synthetase [Escherichia co...
311
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1YOE
99.4%
Escherichia coli
Protein synthesis: tRNA aminoacylation
IDP05304
(
show subtarget assignments
)
1
cloned
No
Z1313
12514147
helD
DNA helicase IV [Escherichia coli O157:H...
715
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2IS1
14.3%
Escherichia coli
DNA metabolism: DNA replication, recombination, and repair
IDP05343
(
show subtarget assignments
)
1
soluble
No
Z1544
12514412
putative acyl-carrier protein synthase [...
122
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1FTE
36.1%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP05344
(
show subtarget assignments
)
1
in_crystallization_trials
No
Z1549
12514420
putative beta-ketoacyl-[acyl carrier pro...
852
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1J3N
18.2%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP05772
(
show subtarget assignments
)
1
cloned
No
Z3171
12516188
dacD
penicillin binding protein 6b [Escherich...
425
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1NZO
40.7%
Escherichia coli
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05345
(
show subtarget assignments
)
1
soluble
No
Z3383
12516442
pbpG
penicillin-binding protein 7 [Escherichi...
313
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1XP4
25.9%
Escherichia coli
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP90005
(
show subtarget assignments
)
8
soluble
No
Z4377
12517595
qseB
quorum sensing Escherichia coli regulato...
219
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3Q9S
41.1%
Escherichia coli
IDP90007
(
show subtarget assignments
)
8
cloned
No
Z4378
12517596
qseC
quorum sensing Escherichia coli regulato...
449
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3JZ3
47%
Escherichia coli
IDP05084
(
show subtarget assignments
)
1
in_crystallization_trials
No
Z4803
12518085
putative ATP-dependent DNA helicase (tog...
202
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1OYW
33.7%
Escherichia coli
DNA metabolism: DNA replication, recombination, and repair
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