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Targets
Filter Targets:
Selection Phase:
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Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 4 of 60, showing 100 records out of 5973 total, starting on record 301
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP02785
(
show subtarget assignments
)
1
cloned
No
STM0378
16763758
yaiY
putative inner membrane protein [Salmone...
102
Conserved; Essential; Drug target functions
Phase 3: June 2008
Salmonella enterica
Cell envelope
Other
IDP05115
(
show subtarget assignments
)
1
cloned
No
CD2567
126700186
PTS system, IIB component [Clostridium d...
102
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2R48
43.1%
Clostridium difficile
Signal transduction: PTS
IDP05551
(
show subtarget assignments
)
1
cloned
No
CD3049
126700667
putative PTS system, IIB component [Clos...
102
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2L2Q
24.5%
Clostridium difficile
Signal transduction: PTS
IDP04617
(
show subtarget assignments
)
1
expressed
No
BAS4342
49187337
50S ribosomal protein L21 [Bacillus anth...
102
Proposed to be essential proteins
Phase 4: April 2009
1VSA
54.9%
Bacillus anthracis
IDP91418
(
show subtarget assignments
)
8
expressed
No
VV1_0671
27364128
rplU
50S ribosomal protein L21 [Vibrio vulnif...
103
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1VS6
78.6%
Vibrio vulnificus
IDP90322
(
show subtarget assignments
)
8
expressed
No
CT_809
3329276
hypothetical protein [Chlamydia trachoma...
103
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP05718
(
show subtarget assignments
)
1
expressed
No
BA_1601
30255901
putative lipoprotein [Bacillus anthracis...
103
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP02444
(
show subtarget assignments
)
1
cloned
No
YPO2224
16122453
hypothetical protein YPO2224 [Yersinia p...
103
Conserved; Drug target functions
Phase 3: June 2008
Yersinia pestis
Cell envelope
Other
IDP02016
(
show subtarget assignments
)
1
cloned
No
YPO0252
16120589
hypothetical protein YPO0252 [Yersinia p...
103
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
Yersinia pestis
Cell envelope
Other
IDP00640
(
show subtarget assignments
)
1
in_pdb
3EME
3MZZ
No
SACOL1807
57286241
rhodanese-like domain protein
103
Drug Target Function
Phase 2: March 2008
3EME
100%
Staphylococcus aureus
Unknown function
General
IDP02447
(
show subtarget assignments
)
1
in_crystallization_trials
No
lmo0561
16802604
hisE
phosphoribosyl-ATP pyrophosphatase [List...
103
Predicted Essential-Modeling; DNA binding Motifs
Phase 3: June 2008
1YVW
54.4%
Listeria monocytogenes
Amino acid biosynthesis
Histidine family
IDP90516
(
show subtarget assignments
)
8
expressed
No
Cj0535
15791896
oorD
2-oxoglutarate-acceptor oxidoreductase s...
103
Predicted Essential
Community Requests
1HFE
31.1%
Campylobacter jejuni
IDP00724
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL1822
57286255
arsR
arsenical resistance operon repressor
104
Conserved Gene / Pathway
Phase 2: March 2008
1R1T
31.7%
Staphylococcus aureus
Cellular processes
Detoxification
IDP05282
(
show subtarget assignments
)
1
soluble
No
CD0228
126697799
fliN
flagellar motor switch protein [Clostrid...
104
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1O6A
23.1%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP90097
(
show subtarget assignments
)
8
cloned
No
ZZZ_0013
104
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP04067
(
show subtarget assignments
)
1
purified
No
BAS4417
49187412
thioredoxin [Bacillus anthracis str. Ste...
104
Proposed to be essential proteins
Phase 4: April 2009
2GZY
75%
Bacillus anthracis
IDP02136
(
show subtarget assignments
)
1
purified
No
YPO0114
16120460
metJ
transcriptional repressor protein MetJ [...
105
Involved in virulence; Drug target functions
Phase 3: June 2008
1CMA
88.6%
Yersinia pestis
Regulatory functions
DNA interactions
IDP00120
(
show subtarget assignments
)
1
expressed
No
NT01ST0780
16764019
ybeB
hypothetical protein STM0642
105
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2ID1
38.1%
Salmonella enterica
Cell envelope
Other
IDP90412
(
show subtarget assignments
)
8
expressed
No
CT_657
3329107
hypothetical protein [Chlamydia trachoma...
105
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP02043
(
show subtarget assignments
)
1
expressed
No
Cj1145c
15792470
hypothetical protein Cj1145c [Campylobac...
105
Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...
Phase 3: June 2008
Campylobacter jejuni
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP05349
(
show subtarget assignments
)
1
cloned
No
CD2487
126700104
PTS system, IIB component [Clostridium d...
105
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KYR
67.6%
Clostridium difficile
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
IDP02795
(
show subtarget assignments
)
1
in_pdb
3LNO
Yes
GBAA5281
47530589
hypothetical protein GBAA5281 [Bacillus ...
105
Conserved; Involved in sporulation;
Phase 3: June 2008
3LNO
100%
Bacillus anthracis
Hypothetical proteins
Conserved
IDP00410
(
show subtarget assignments
)
1
cloned
No
YPO0548
16120876
ftsL
cell division protein FtsL
105
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Cell division
IDP90114
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_023
68449097
kelch-like protein [Monkeypox virus]
105
similar to MPXV-ZAI96-D18L, part of VACV-COP-C2L
Community Requests
Monkeypox virus
IDP91328
(
show subtarget assignments
)
8
expressed
No
VV2_0290
27366736
ribonuclease G and E [Vibrio vulnificus ...
105
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP05479
(
show subtarget assignments
)
1
soluble
No
BA_3874
30258390
hypothetical protein BA_3874 [Bacillus a...
105
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05015
(
show subtarget assignments
)
1
cloned
No
CD0247
126697818
fliE
flagellar hook-basal body protein FliE [...
105
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP00141
(
show subtarget assignments
)
1
crystallized
No
VC0401
15640428
mshK
MSHA biogenesis protein MshK
105
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP92084
(
show subtarget assignments
)
8
selected
No
TGME49_112250
237830299
DNA-directed RNA polymerase III subunit,...
106
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3QT1
41.3%
Toxoplasma gondii
IDP91643
(
show subtarget assignments
)
8
cloned
No
NP_215860
15608484
acyl carrier protein [Mycobacterium tube...
106
virulence/pathogenesis /
All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...
Community Requests
4DXE
19.8%
Mycobacterium tuberculosis
IDP05311
(
show subtarget assignments
)
1
cloned
No
CD3014
126700634
PTS system, IIB component [Clostridium d...
106
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2R4Q
45.3%
Clostridium difficile
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
IDP00198
(
show subtarget assignments
)
1
cloned
No
YPO1367
16121647
-
conserved hypothetical protein
106
Similar to Essential SALTY
Phase 1: October 2007
1MBU
84.9%
Yersinia pestis
IDP05468
(
show subtarget assignments
)
1
expressed
No
BA_2103
30256751
hypothetical protein BA_2103 [Bacillus a...
106
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP01322
(
show subtarget assignments
)
1
purified
No
VC2296
15642294
bolA protein
106
Conserved Gene / Pathway
Phase 2: March 2008
2DHM
50.9%
Vibrio cholerae
Cellular processes
Other
IDP05665
(
show subtarget assignments
)
1
purified
No
lmo0427
16802471
-
hypothetical protein lmo0427 [Listeria m...
106
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2R4Q
46.2%
Listeria monocytogenes
Regulatory functions: Other
IDP05290
(
show subtarget assignments
)
1
cloned
No
CD0488
126698065
sugE
quaternary ammonium compound-resistance ...
106
virulence/pathogenesis /
Targets associated with virulence and/or pathogenesis
Phase 5: 2010
2I68
30.2%
Clostridium difficile
Cellular processes: Toxin production and resistance
IDP02690
(
show subtarget assignments
)
1
cloned
No
FTT0954c
56708048
hypothetical protein FTT0954c [Francisel...
106
Drug Target
Phase 3: June 2008
1Y2I
36.8%
Francisella tularensis
Unclassified
Role category not yet assigned
IDP01100
(
show subtarget assignments
)
1
in_pdb
3K1S
No
BA_5442
30259910
celC-2
PTS system, cellobiose-specific IIA comp...
107
Conserved Gene / Pathway
Phase 2: March 2008
3K1S
99.1%
Bacillus anthracis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP05379
(
show subtarget assignments
)
1
soluble
No
BA_5417
30259888
cccB
cytochrome c-551 [Bacillus anthracis str...
107
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1B7V
29.9%
Bacillus anthracis
Energy metabolism: Electron transport
IDP05253
(
show subtarget assignments
)
1
cloned
No
CD0259
126697831
putative flagellar protein [Clostridium ...
107
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP91375
(
show subtarget assignments
)
8
purified
No
VV1_2191
27365520
hypothetical protein VV1_2191 [Vibrio vu...
107
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP02293
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT1445
56708487
trxA1
thioredoxin [Francisella tularensis subs...
107
Conserved; Drug target functions
Phase 3: June 2008
2H71
50.5%
Francisella tularensis
Energy metabolism
Electron transport
IDP04041
(
show subtarget assignments
)
1
cloned
No
YPCD1.16c
5832438
YPCD1.16c
hypothetical protein YPCD1.16c [Yersinia...
107
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP90116
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_025
68449099
kelch-like protein [Monkeypox virus]
107
similar to MPXV-ZAI96-D18L, part of VACV-COP-C2L
Community Requests
3HVE
21.5%
Monkeypox virus
IDP91345
(
show subtarget assignments
)
8
expressed
No
VV1_3181
27366441
transposase [Vibrio vulnificus CMCP6]
107
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP05702
(
show subtarget assignments
)
1
expressed
No
lmo2568
16804606
-
hypothetical protein lmo2568 [Listeria m...
107
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
Hypothetical proteins: Conserved
IDP91434
(
show subtarget assignments
)
8
soluble
No
VV1_0486
27363950
ribosome-associated protein Y [Vibrio vu...
107
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1IMU
50.5%
Vibrio vulnificus
IDP01812
(
show subtarget assignments
)
1
cloned
No
FTT1764c
56708759
ferredoxin [Francisella tularensis subsp...
107
Conserved; Drug target functions
Phase 3: June 2008
1A6L
64.5%
Francisella tularensis
Energy metabolism
Electron transport
IDP90206
(
show subtarget assignments
)
8
soluble
No
MYXV_gp149
9633781
m146R
m146R
108
virokine/NFkB inh/Str resemblence to apoptotic reg, similar to VACV-Cop:N1L
Community Requests
2I39
26.9%
Myxoma virus
host defense modulator
0
IDP01867
(
show subtarget assignments
)
1
cloned
No
YPO0160
16120503
nirD
nitrite reductase small subunit [Yersini...
108
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
2JZA
71.3%
Yersinia pestis
Energy metabolism
Anaerobic
IDP01747
(
show subtarget assignments
)
1
soluble
No
STM2407
16765733
ypeC
putative periplasmic protein [Salmonella...
108
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP01950
(
show subtarget assignments
)
1
expressed
No
STM1939
16765280
putative glucose-6-phosphate dehydrogena...
108
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Energy metabolism
Glycolysis/gluconeogenesis
IDP91045
(
show subtarget assignments
)
8
cloned
No
ECH0010
15799700
hypothetical protein Z0021 [Escherichia ...
108
virulence/pathogenesis /
Hypothetical protein Z0021 is involved in regulation of swimming motility in E. ...
Community Requests
Escherichia coli
IDP91039
(
show subtarget assignments
)
8
selected
No
Sd1012_5151
194431100
hdeB
HdeB protein [Shigella dysenteriae 1012]...
108
potential drug target /
A protein that is important for acid resistance in some enteropathogens; it is a...
Community Requests
2XUV
65.7%
Shigella dysenteriae
IDP02326
(
show subtarget assignments
)
1
purified
No
FTT0976
56708068
trxA2
thioredoxin [Francisella tularensis subs...
108
Drug Target
Phase 3: June 2008
1SYR
41.7%
Francisella tularensis
Energy metabolism
Electron transport
IDP01819
(
show subtarget assignments
)
1
cloned
No
STM1145
16764501
csgC
putative autoagglutination protein [Salm...
108
Conserved; Drug target functions
Phase 3: June 2008
2Y2T
64.8%
Salmonella enterica
Unclassified
Role category not yet assigned
IDP05281
(
show subtarget assignments
)
1
in_crystallization_trials
No
CD0136
126697708
PTS system, IIB component [Clostridium d...
108
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1H9C
42.2%
Clostridium difficile
Signal transduction: PTS
IDP05471
(
show subtarget assignments
)
1
expressed
No
BA_2159
30256804
conserved domain protein [Bacillus anthr...
108
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Domain
IDP90548
(
show subtarget assignments
)
8
cloned
No
Cj0960c
15792289
rnpA
ribonuclease P protein component [Campyl...
108
Predicted Essential
Community Requests
1A6F
27.9%
Campylobacter jejuni
IDP02296
(
show subtarget assignments
)
1
crystallized
No
GBAA0020
47525275
hypothetical protein GBAA0020 [Bacillus ...
109
Conserved; Involved in sporulation;
Phase 3: June 2008
1YBX
55.8%
Bacillus anthracis
Hypothetical proteins
Conserved
IDP91365
(
show subtarget assignments
)
8
soluble
No
VV1_2710
27366000
dissimilatory sulfite reductase, gamma s...
109
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1YX3
48.6%
Vibrio vulnificus
IDP90418
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_466
3328900
hypothetical protein [Chlamydia trachoma...
109
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP05682
(
show subtarget assignments
)
1
cloned
No
lmo1303
16803343
-
hypothetical protein lmo1303 [Listeria m...
109
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
Unclassified: Role category not yet assigned
IDP90399
(
show subtarget assignments
)
8
expressed
No
CT_569
3329010
gspG
predicted OMP [Chlamydia trachomatis D/U...
109
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01112
(
show subtarget assignments
)
1
in_pdb
3G48
No
BA_2064
30256713
csaA
chaperone CsaA
109
Conserved Gene / Pathway
Phase 2: March 2008
3G48
99.1%
Bacillus anthracis
Protein fate
Protein and peptide secretion and trafficking
IDP04298
(
show subtarget assignments
)
1
in_crystallization_trials
No
VCA0827
15601582
phhB
pterin-4-alpha-carbinolamine dehydratase...
109
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1RU0
33%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP90082
(
show subtarget assignments
)
8
purified
No
P03493.2
85681917
RecName: Full=Matrix protein 2; AltName:...
109
Influenza matrix protein 2 (M2) is a validated therapeutic target whose on-marke...
Community Requests
2KJ1
64.2%
Influenza B
IDP00080
(
show subtarget assignments
)
1
expressed
No
NT01ST5073
16422645
yneC
putative inner membrane protein
109
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3QMQ
70.6%
Salmonella enterica
Cell envelope
Other
IDP02808
(
show subtarget assignments
)
1
cloned
No
STM1084
16764443
yccK
sulfurtransferase TusE [Salmonella typhi...
109
Conserved; Drug target functions
Phase 3: June 2008
1YX3
47.7%
Salmonella enterica
Unknown function
General
IDP04047
(
show subtarget assignments
)
1
cloned
No
YPCD1.92
5832507
YPCD1.92
hypothetical protein YPCD1.92 [Yersinia ...
109
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP02774
(
show subtarget assignments
)
1
soluble
No
FTT0392c
56707541
hypothetical protein FTT0392c [Francisel...
109
Drug Target
Phase 3: June 2008
Francisella tularensis
Unclassified
Role category not yet assigned
IDP05474
(
show subtarget assignments
)
1
soluble
No
BA_2749
30257354
conserved hypothetical protein [Bacillus...
110
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP05604
(
show subtarget assignments
)
1
expressed
No
BA_4769
30259256
putative spore coat protein C [Bacillus ...
110
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cellular processes: Sporulation and germination
IDP05664
(
show subtarget assignments
)
1
purified
No
lmo0341
16802386
-
hypothetical protein lmo0341 [Listeria m...
110
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2IP6
30%
Listeria monocytogenes
Transport and binding proteins: Other
IDP91374
(
show subtarget assignments
)
8
cloned
No
VV1_1919
27365265
outermembrane lipoprotein [Vibrio vulnif...
110
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP02206
(
show subtarget assignments
)
1
soluble
No
lmo0065
16802113
hypothetical protein lmo0065 [Listeria m...
110
Predicted virulence-Type III; Type IV; ESAT secretion systems
Phase 3: June 2008
Listeria monocytogenes
Cellular processes
Pathogenesis
IDP00277
(
show subtarget assignments
)
1
cloned
No
AAA99437_5-114
323469
N/A
Capsid protein (C)
110
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
57.3%
Dengue virus
Unclassified
N/A
IDP01307
(
show subtarget assignments
)
1
soluble
No
VC1283
15641296
PTS system, cellobiose-specific IIA comp...
111
Conserved Gene / Pathway
Phase 2: March 2008
1WCR
45.9%
Vibrio cholerae
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP00267
(
show subtarget assignments
)
1
cloned
No
AAX48017_4-113
61652905
N/A
Capsid protein (C)
111
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
60.4%
Dengue virus
Unclassified
N/A
IDP04053
(
show subtarget assignments
)
1
cloned
No
CPF_2307
110801393
spoIIAA
anti-sigma F factor antagonist [Clostrid...
111
conserved gene; putative drug target function;
Phase 4: April 2009
1TH8
45%
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP02067
(
show subtarget assignments
)
1
purified
No
FTT0825c
56707936
hypothetical protein FTT0825c [Francisel...
111
Drug Target
Phase 3: June 2008
Francisella tularensis
Cell envelope
Other
IDP05013
(
show subtarget assignments
)
1
expressed
No
CD0238
126697809
hypothetical protein CD0238 [Clostridium...
111
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP02730
(
show subtarget assignments
)
1
in_pdb
3OUG
Yes
FTT1391
56708440
panD
aspartate alpha-decarboxylase [Francisel...
111
Drug Target
Phase 3: June 2008
3OUG
100%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Pantothenate and coenzyme A
IDP02144
(
show subtarget assignments
)
1
cloned
No
FTT1136c
56708211
hypothetical protein FTT1136c [Francisel...
111
Drug Target
Phase 3: June 2008
Francisella tularensis
Cell envelope
Other
IDP04117
(
show subtarget assignments
)
8
selected
No
CAC05825
12329094
spa13
spa13, component of the Mxi-Spa secretio...
112
Shigella effector protein
Community Requests
Shigella flexneri
IDP01904
(
show subtarget assignments
)
1
soluble
No
STM2685
16766000
smpA
hypothetical protein STM2685 [Salmonella...
112
Conserved; Drug target functions
Phase 3: June 2008
2KM7
74.1%
Salmonella enterica
Unknown function
General
IDP04339
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0115
49183149
50S ribosomal protein L22 [Bacillus anth...
113
Proposed to be essential proteins
Phase 4: April 2009
1BXE
59.3%
Bacillus anthracis
IDP05442
(
show subtarget assignments
)
1
cloned
No
BA_0171
30253680
putative lipoprotein [Bacillus anthracis...
113
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP05246
(
show subtarget assignments
)
1
soluble
No
lmo2439
16804477
-
hypothetical protein lmo2439 [Listeria m...
113
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2K5Q
33.6%
Listeria monocytogenes
Unclassified: Role category not yet assigned
IDP01649
(
show subtarget assignments
)
1
expressed
No
CBU_0796
29541390
HIT family protein [Coxiella burnetii RS...
113
Conserved; Drug target functions
Phase 3: June 2008
1AV5
49.6%
Coxiella burnetii
Unknown function
General
IDP04289
(
show subtarget assignments
)
1
expressed
No
YPCD1.35c
16082723
yscY
hypothetical protein YPCD1.35c [Yersinia...
114
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP00263
(
show subtarget assignments
)
1
cloned
No
AF180817_1-114
7329982
N/A
Capsid protein (C)
114
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
60.5%
Dengue virus
Unclassified
N/A
IDP02672
(
show subtarget assignments
)
1
cloned
No
FTT1602
56708622
hypothetical protein FTT1602 [Francisell...
114
Drug Target
Phase 3: June 2008
Francisella tularensis
Cell envelopeUnknown function
OtherGeneral
IDP01255
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_5132
30259616
yugI
general stress protein 13
114
Conserved Gene / Pathway
Phase 2: March 2008
2K4K
53.3%
Bacillus anthracis
Cellular processes
Adaptations to atypical conditions
IDP91494
(
show subtarget assignments
)
8
purified
No
VP1691
28898465
type III export protein [Vibrio parahaem...
114
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP00103
(
show subtarget assignments
)
1
in_crystallization_trials
No
NT01SF3270
30042295
ygaC
hypothetical protein S2885
114
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2G7J
86.8%
Shigella flexneri
Cell envelope
Other
IDP91307
(
show subtarget assignments
)
8
expressed
No
VP1663
28898437
putative YscY [Vibrio parahaemolyticus R...
114
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2FO7
22.8%
Vibrio parahaemolyticus
IDP05643
(
show subtarget assignments
)
1
soluble
No
CD3082
126700699
PTS system, IIB component [Clostridium d...
114
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1H9C
29.8%
Clostridium difficile
Signal transduction: PTS
IDP00081
(
show subtarget assignments
)
1
in_crystallization_trials
No
NT01ST5473
16422973
ytfP
putative cytoplasmic protein
114
Essential
Phase 1: October 2007
1XHS
92.1%
Salmonella enterica
Unknown function
General
IDP04138
(
show subtarget assignments
)
1
expressed
No
YPO0811
218927991
general secretion pathway protein I [Yer...
114
putative drug target function;
Phase 4: April 2009
3CI0
19.3%
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
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