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Targets
Filter Targets:
Selection Phase:
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Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP02635
(
show subtarget assignments
)
1
soluble
No
GBAA5421
47530734
secA
preprotein translocase subunit SecA [Bac...
835
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
1TF2
72.8%
Bacillus anthracis
Protein fate
Protein and peptide secretion and trafficking
IDP00525
(
show subtarget assignments
)
1
cloned
No
YPMT1.83
16082875
caf1A
putative F1 capsule anchoring protein
833
Virulence Associated Factor
Phase 2: March 2008
3RFZ
35.3%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP05656
(
show subtarget assignments
)
1
cloned
No
lmo0171
16802219
-
hypothetical protein lmo0171 [Listeria m...
832
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2OMX
13.7%
Listeria monocytogenes
Cellular processes: Pathogenesis
IDP91361
(
show subtarget assignments
)
8
cloned
No
VV1_2840
27366122
NhaP-type Na+/H+ and K+/H+ antiporters [...
831
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04733
(
show subtarget assignments
)
1
cloned
No
CBU_0789
215919045
two component system histidine kinase [C...
831
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
10.5%
Coxiella burnetii
Signal transduction
Two-component systems
IDP00274
(
show subtarget assignments
)
1
selected
No
AF180817_2494-3392
7329982
N/A
NS5 methyl transferase and RNA polymeras...
830
RNA-dependent RNA polymerase
Phase 3: June 2008
2J7U
55.5%
Dengue virus
Transcription
N/A
IDP90953
(
show subtarget assignments
)
8
expressed
No
VF0985
75354249
Sensory box/GGDEF family protein
827
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3HVB
12.1%
Vibrio fischeri
IDP02791
(
show subtarget assignments
)
1
cloned
No
lmo1892
16803931
pbpA
hypothetical protein lmo1892 [Listeria m...
827
Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...
Phase 3: June 2008
2OLU
30.8%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00592
(
show subtarget assignments
)
1
cloned
No
YPO3393
16123542
mrcB
penicillin-binding protein 1b
824
Virulence Associated Factor
Phase 2: March 2008
3VMA
66.7%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP04573
(
show subtarget assignments
)
1
crystallized
No
BAS0006
49183045
DNA gyrase subunit A [Bacillus anthracis...
823
Proposed to be essential proteins
Phase 4: April 2009
2XCO
42.9%
Bacillus anthracis
IDP05548
(
show subtarget assignments
)
1
cloned
No
lmo0409
16802454
-
hypothetical protein lmo0409 [Listeria m...
821
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1O6S
23.8%
Listeria monocytogenes
Cellular processes: Pathogenesis
IDP90315
(
show subtarget assignments
)
8
cloned
No
CT_744
3329204
CHLTR possible phosphoprotein [Chlamydia...
821
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01243
(
show subtarget assignments
)
1
cloned
No
BA_2345
30256982
penicillin-binding protein 1A
820
Drug Target Function
Phase 2: March 2008
2OLU
29.5%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02389
(
show subtarget assignments
)
1
cloned
No
lmo0232
16802278
clpC
endopeptidase Clp ATP-binding chain C [L...
820
Known virulence-Invasion; PMID:11083831; Presence of Protease Motifs
Phase 3: June 2008
3PXI
72.8%
Listeria monocytogenes
Energy metabolism
ATP-proton motive force interconversion
IDP05329
(
show subtarget assignments
)
1
soluble
No
BA_0815
30254405
purple acid phosphatase/fibronectin doma...
819
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2HY1
6%
Bacillus anthracis
Unknown function: General
IDP02479
(
show subtarget assignments
)
1
cloned
No
lmo1287
16803327
parC
DNA topoisomerase IV subunit A [Listeria...
819
Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...
Phase 3: June 2008
2INR
41.8%
Listeria monocytogenes
DNA metabolism
DNA replication, recombination, and repair
IDP90346
(
show subtarget assignments
)
8
cloned
No
CT344
15605067
lon
ATP-dependent protease La [Chlamydia tra...
819
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3M6A
30.8%
Chlamydia trachomatis
IDP02559
(
show subtarget assignments
)
1
cloned
No
YPO3325
16123478
dmsA
anaerobic dimethyl sulfoxide reductase c...
816
Conserved; CD; Drug target functions
Phase 3: June 2008
1E60
28.7%
Yersinia pestis
Biosynthesis of cofactors, prosthetic groups, and carriers
Biotin
IDP04033
(
show subtarget assignments
)
1
soluble
No
VC1950
15641952
biotin sulfoxide reductase [Vibrio chole...
815
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1E18
48.7%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Biotin
IDP00226
(
show subtarget assignments
)
1
soluble
No
YPO3938
16124066
glgP
glycogen phosphorylase
815
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 1: October 2007
1EM6
49.9%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP90795
(
show subtarget assignments
)
8
cloned
No
YPO3244
16123403
fadE
acyl-CoA dehydrogenase [Yersinia pestis ...
815
Predicted Essential
Community Requests
2UXW
18.8%
Yersinia pestis
IDP05155
(
show subtarget assignments
)
1
expressed
No
BA_0885
30254634
sap
S-layer protein Sap [Bacillus anthracis ...
814
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3PYW
22.4%
Bacillus anthracis
Cell envelope: Surface structures
IDP91541
(
show subtarget assignments
)
8
selected
No
TGME49_118680
237841017
3',5'--cyclic-nucleotide phosphodiestera...
812
potential drug target /
Phosphodiesterases are key regulators of cell signalling pathways and are attrac...
Community Requests
3QI3
13.8%
Toxoplasma gondii
IDP90945
(
show subtarget assignments
)
8
purified
No
VP0092
28896866
hypothetical protein VP0092 [Vibrio para...
811
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3HVB
13.7%
Vibrio parahaemolyticus
IDP00585
(
show subtarget assignments
)
1
expressed
No
YPO0116
16120461
metL
bifunctional aspartate kinase II/homoser...
811
Virulence Associated Factor
Phase 2: March 2008
1EBF
15.5%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP01877
(
show subtarget assignments
)
1
crystallized
No
GBAA0080
47525336
negative regulator of genetic competence...
811
Drug target motif; Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3PXI
80.1%
Bacillus anthracis
Cellular processes
DNA transformation
IDP91812
(
show subtarget assignments
)
8
soluble
No
b0823
1787044
ybiW
predicted pyruvate formate lyase [Escher...
810
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1R8W
37.1%
Escherichia coli
IDP91687
(
show subtarget assignments
)
8
selected
No
NP_000292
4505881
PLG
plasminogen isoform 1 precursor [Homo sa...
810
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
4DUR
97.7%
Homo sapiens
IDP90580
(
show subtarget assignments
)
8
cloned
No
Cj1091c
15792416
leuS
leucyl-tRNA synthetase [Campylobacter je...
809
Predicted Essential
Community Requests
1H3N
42.1%
Campylobacter jejuni
IDP92554
(
show subtarget assignments
)
8
selected
No
VV1_1165
27360700
Glycerol-3-phosphate acyltransferase [Vi...
809
potential drug target /
Proteins are in a pathway we are investigating for playing a role in symbiont nu...
Community Requests
Vibrio vulnificus
IDP90958
(
show subtarget assignments
)
8
cloned
No
UTI89_C1702
122423767
Hypothetical protein
807
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
1V9Y
18%
Escherichia coli
IDP00869
(
show subtarget assignments
)
1
cloned
No
STM4235
16767485
plsB
glycerol-3-phosphate acyltransferase
806
Essential Gene
Phase 2: March 2008
Salmonella enterica
Fatty acid and phospholipid metabolism
Biosynthesis
IDP04383
(
show subtarget assignments
)
1
purified
No
BAS4455
49187450
phenylalanyl-tRNA synthetase subunit bet...
806
Proposed to be essential proteins
Phase 4: April 2009
2RHS
49.8%
Bacillus anthracis
IDP90603
(
show subtarget assignments
)
8
selected
No
VC0015
15640047
gyrB
DNA gyrase subunit B [Vibrio cholerae O1...
805
Predicted Essential
Community Requests
1EI1
39.6%
Vibrio cholerae
IDP05334
(
show subtarget assignments
)
1
soluble
No
SACOL1808
57652056
leuS
leucyl-tRNA synthetase [Staphylococcus a...
805
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1H3N
46.4%
Staphylococcus aureus
Protein synthesis: tRNA aminoacylation
IDP90819
(
show subtarget assignments
)
8
purified
No
YPO4094
16124203
gyrB
DNA gyrase subunit B [Yersinia pestis CO...
804
Predicted Essential
Community Requests
1EI1
43.7%
Yersinia pestis
IDP02728
(
show subtarget assignments
)
1
purified
No
lmo1660
16803700
leuS
leucyl-tRNA synthetase [Listeria monocyt...
803
DNA binding Motifs; Drug Target Homologs
Phase 3: June 2008
1H3N
44.1%
Listeria monocytogenes
Protein synthesis
tRNA aminoacylation
IDP05745
(
show subtarget assignments
)
1
expressed
No
CD2787
126700403
cwp84
cell surface protein (putative cell surf...
803
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1FH0
8.2%
Clostridium difficile
Cell envelope: Other
IDP91558
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAB38076
13364128
ECs4653
hypothetical protein [Escherichia coli O...
802
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP04027
(
show subtarget assignments
)
1
cloned
No
BAS4637
49187628
leucyl-tRNA synthetase [Bacillus anthrac...
802
Proposed to be essential proteins
Phase 4: April 2009
1H3N
45.9%
Bacillus anthracis
IDP01646
(
show subtarget assignments
)
1
soluble
No
GBAA5119
47530423
glgP
glycogen phosphorylase [Bacillus anthrac...
802
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1AXR
46.5%
Bacillus anthracis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP01893
(
show subtarget assignments
)
1
expressed
No
PSLT017
17233482
pefC
usher protein [Salmonella typhimurium LT...
802
Conserved; Drug target functions
Phase 3: June 2008
3RFZ
27.7%
Salmonella enterica
Unclassified
Role category not yet assigned
IDP05679
(
show subtarget assignments
)
1
cloned
No
lmo1222
16803262
pheT
phenylalanyl-tRNA synthetase beta subuni...
802
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2RHS
49.5%
Listeria monocytogenes
Protein synthesis: tRNA aminoacylation
IDP02018
(
show subtarget assignments
)
1
expressed
No
STM2530
16765850
putative anaerobic dimethylsulfoxide red...
801
Conserved; Drug target functions
Phase 3: June 2008
1DMR
30.1%
Salmonella enterica
Energy metabolism
Anaerobic
IDP90200
(
show subtarget assignments
)
8
purified
No
AAM13652.1
20153191
CPXV213 CDS
CPXV213 protein
800
ankyrin-like protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP05709
(
show subtarget assignments
)
1
soluble
No
SACOL1149
57651748
pheT
phenylalanyl-tRNA synthetase, beta subun...
800
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2RHS
77.6%
Staphylococcus aureus
Protein synthesis: tRNA aminoacylation
IDP04387
(
show subtarget assignments
)
1
expressed
No
YPO3606
218930616
putative Rhs accessory genetic element [...
800
virulence factor; putative drug target function;
Phase 4: April 2009
2P5Z
14.4%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP05666
(
show subtarget assignments
)
1
soluble
No
lmo0433
16802477
inlA
internalin A [Listeria monocytogenes EGD...
800
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1O6S
57.6%
Listeria monocytogenes
Cellular processes: Pathogenesis
IDP00006
(
show subtarget assignments
)
1
soluble
No
BA_0672
30254271
immune inhibitor A metalloprotease
799
Virulence/Drug Target Homolog
Phase 1: October 2007
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00048
(
show subtarget assignments
)
1
cloned
No
BA_3330
30257875
beta-lactam antibiotic acylase family pr...
796
Virulence
Phase 1: October 2007
1KEH
22.2%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP90174
(
show subtarget assignments
)
8
cloned
No
AAM13466.1
20153005
CPXV019 CDS
CPXV019 protein
796
ankyrin repeat protein
Community Requests
3HG0
3.8%
Cowpox virus
conserved hypothetical proteins
0
IDP90870
(
show subtarget assignments
)
8
purified
No
VC1220
15641233
pheT
phenylalanyl-tRNA synthetase subunit bet...
795
Predicted Essential
Community Requests
3PCO
64.4%
Vibrio cholerae
IDP90932
(
show subtarget assignments
)
8
expressed
No
YPO2428
16122648
pheT
phenylalanyl-tRNA synthetase subunit bet...
795
Predicted Essential
Community Requests
3PCO
83.4%
Yersinia pestis
IDP90809
(
show subtarget assignments
)
8
selected
No
S1635
30063020
pheT
phenylalanyl-tRNA synthetase subunit bet...
795
Predicted Essential
Community Requests
3PCO
99.5%
Shigella flexneri
IDP04350
(
show subtarget assignments
)
1
cloned
No
STM1338_1_795
16764689
pheT
phenylalanyl-tRNA synthetase subunit bet...
795
Salmonella essential protein
Phase 4: April 2009
3PCO
92.6%
Salmonella enterica
IDP05107
(
show subtarget assignments
)
1
soluble
No
CD1751
126699358
cell surface protein (putative cell surf...
795
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1VSN
8.4%
Clostridium difficile
Cell envelope: Other
IDP00033
(
show subtarget assignments
)
1
cloned
No
BA_1295
30255240
immune inhibitor A metalloprotease
795
Virulence
Phase 1: October 2007
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP91556
(
show subtarget assignments
)
8
expressed
No
BAB38080
13364132
ECs4657
hypothetical protein [Escherichia coli O...
794
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP92019
(
show subtarget assignments
)
8
selected
No
TGME49_047760
237835691
long chain acyl-CoA synthetase, putative...
793
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3A9U
16.9%
Toxoplasma gondii
IDP05655
(
show subtarget assignments
)
1
soluble
No
lmo0159
16802207
-
peptidoglycan binding protein [Listeria ...
793
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3KPT
14.4%
Listeria monocytogenes
Cell envelope: Other
IDP02583
(
show subtarget assignments
)
1
soluble
No
GBAA5249
47530554
3-hydroxyacyl-CoA dehydrogenase/enoyl-Co...
793
Conserved; Drug target functions
Phase 3: June 2008
1WDK
14.6%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Degradation
IDP04361
(
show subtarget assignments
)
1
soluble
No
YPO2803
218929869
bglB
putative beta-glucosidase [Yersinia pest...
793
drug target; putative drug target function;
Phase 4: April 2009
2X40
37.3%
Yersinia pestis
Energy metabolism
Sugars
IDP00317
(
show subtarget assignments
)
1
cloned
No
CBU_1887
29655172
ponA
penicillin-binding protein 1A
793
Drug Target Function
Phase 2: March 2008
3UDF
40.4%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02147
(
show subtarget assignments
)
1
cloned
No
YPO0134
16120477
hypothetical protein YPO0134 [Yersinia p...
791
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
2OCE
61.4%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP04227
(
show subtarget assignments
)
1
expressed
No
CPF_0198
110799765
sensory box histidine kinase [Clostridiu...
791
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
11.6%
Clostridium perfringens
Regulatory functions
IDP91367
(
show subtarget assignments
)
8
expressed
No
VV1_2638
27365931
NAD-specific glutamate dehydrogenase [Vi...
789
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP90146
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_193
68449265
ankyrin-like protein [Monkeypox virus]
789
similar to VACV-COP-B20R, MPXV-ZAI96-B17R
Community Requests
1MJ0
5.2%
Monkeypox virus
IDP90664
(
show subtarget assignments
)
8
cloned
No
Cj0024
15791423
nrdA
ribonucleotide-diphosphate reductase sub...
789
Predicted Essential
Community Requests
3HNC
33.7%
Campylobacter jejuni
IDP02316
(
show subtarget assignments
)
1
soluble
No
FTT0037
56707217
nuoG
NADH dehydrogenase subunit G [Francisell...
788
Conserved; Drug target functions
Phase 3: June 2008
2FUG
24.2%
Francisella tularensis
Energy metabolism
Electron transport
IDP02495
(
show subtarget assignments
)
1
cloned
No
Cj1565c
15792870
pflA
paralyzed flagella protein PflA [Campylo...
788
Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Unclassified
Unclassified
IDP01191
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_0882
81837776
Protein translocase subunit secA 2
788
Conserved Gene / Pathway
Phase 2: March 2008
1M6N
48%
Bacillus anthracis
Protein fate
Protein and peptide secretion and trafficking
IDP04365
(
show subtarget assignments
)
1
cloned
No
CPF_1523
110798905
sensory box histidine kinase [Clostridiu...
787
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
11.6%
Clostridium perfringens
Regulatory functions
Protein interactions
IDP91033
(
show subtarget assignments
)
8
cloned
No
SAR0023
49240405
sasH
putative 5'-nucleotidase [Staphylococcus...
786
virulence/pathogenesis /
An uncharacterized cell surface protein of staph. aureus with an anchor site for...
Community Requests
2Z1A
22.5%
Staphylococcus aureus
IDP04108
(
show subtarget assignments
)
1
expressed
No
YPO0507
115346316
conserved hypothetical protein [Yersinia...
782
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
2P5Z
13.7%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP04459
(
show subtarget assignments
)
1
cloned
No
YPO1472
115347226
conserved hypothetical protein [Yersinia...
782
virulence factor; putative drug target function;
Phase 4: April 2009
2P5Z
40.7%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP91425
(
show subtarget assignments
)
8
soluble
No
VV1_0550
27364012
aerobic respiration control sensor prote...
780
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3A0R
11.7%
Vibrio vulnificus
IDP02436
(
show subtarget assignments
)
1
cloned
No
Cj1418c
15792736
hypothetical protein Cj1418c [Campylobac...
779
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
Campylobacter jejuni
Energy metabolism
Electron transport
IDP91715
(
show subtarget assignments
)
8
selected
No
NP_008917
52632377
MAGED1
melanoma-associated antigen D1 isoform b...
778
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3NW0
12.1%
Homo sapiens
IDP05771
(
show subtarget assignments
)
1
cloned
No
Z0339
12513053
alpha replication protein of prophage CP...
777
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1KA8
9.5%
Escherichia coli
Mobile and extrachromosomal element functions: Prophage functions
IDP02264
(
show subtarget assignments
)
1
cloned
No
Cj1438c
15792756
putative sugar transferase [Campylobacte...
776
Known Predicted virulence-capsule biosynthesis anmd transport; Possible Vaccine ...
Phase 3: June 2008
3L7I
19.1%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP91017
(
show subtarget assignments
)
8
expressed
No
y2556
22126437
fcuA
ferrichrome receptor, TonB dependent [Ye...
776
other biological interest /
putative iron-binding TonB-dependent outer membrane receptor
Community Requests
3QLB
23.6%
Yersinia pestis
IDP02212
(
show subtarget assignments
)
1
cloned
No
CBU_2048
29542599
metE
5-methyltetrahydropteroyltriglutamate--h...
775
Conserved; Drug target functions
Phase 3: June 2008
1U1H
48.5%
Coxiella burnetii
Amino acid biosynthesis
Aspartate family
IDP01644
(
show subtarget assignments
)
1
cloned
No
FTT0626
56707751
lon
DNA-binding, ATP-dependent protease La [...
774
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
3M6A
37.7%
Francisella tularensis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP00545
(
show subtarget assignments
)
1
cloned
No
YPO2747
16122951
fadJ
multifunctional fatty acid oxidation com...
774
Conserved Gene / Pathway
Phase 2: March 2008
1WDK
34.1%
Yersinia pestis
Cellular processes
Detoxification
IDP91929
(
show subtarget assignments
)
8
selected
No
SpneCM_010100004422
298254845
formate acetyltransferase [Streptococcus...
774
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
1H16
43.6%
Streptococcus pneumoniae
IDP05126
(
show subtarget assignments
)
1
expressed
No
BA_4346
30258846
cpdB
2',3'-cyclic-nucleotide 2'-phosphodieste...
774
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3JYF
20.7%
Bacillus anthracis
Purines, pyrimidines, nucleosides, and nucleotides: Other
IDP02793
(
show subtarget assignments
)
1
cloned
No
GBAA4702
47530001
loN
ATP-dependent protease La 1 [Bacillus an...
773
Drug target motif; Involved in sporulation; Drug target functions
Phase 3: June 2008
3M6A
53.7%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP00097
(
show subtarget assignments
)
1
expressed
No
NTL02SF1117
30040935
S1242
hypothetical protein S1242
773
Virulence
Phase 1: October 2007
3QQ2
9.8%
Shigella flexneri
Cellular processes
Pathogenesis
IDP90629
(
show subtarget assignments
)
8
cloned
No
Cj0896c
15792226
pheT
phenylalanyl-tRNA synthetase subunit bet...
773
Predicted Essential
Community Requests
2RHS
28.6%
Campylobacter jejuni
IDP01007
(
show subtarget assignments
)
1
cloned
No
STM2531
16765851
pbpC
penicillin-binding protein 1C
771
Drug Target Function
Phase 2: March 2008
2OLU
21.5%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP04357
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0894
56707995
purCD
fusion protein PurC/PurD [Francisella tu...
770
conserved gene; putative drug target function;
Phase 4: April 2009
2YRW
20.3%
Francisella tularensis
IDP00664
(
show subtarget assignments
)
1
cloned
No
SACOL1028
57284400
htrA
serine protease
769
Drug Target Function
Phase 2: March 2008
2ZLE
12.7%
Staphylococcus aureus
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP02529
(
show subtarget assignments
)
1
cloned
No
Cj0003
15791402
gyrB
DNA gyrase subunit B [Campylobacter jeju...
769
Predicted virulence-Resistance to antibiotics and toxic compounds
Phase 3: June 2008
1EI1
27.2%
Campylobacter jejuni
Cell envelope
Other
IDP02251
(
show subtarget assignments
)
1
cloned
No
YPO1201
16121494
putative amino acid decarboxylase [Yersi...
768
Involved in virulence; Drug target functions
Phase 3: June 2008
2VYC
51.6%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP90964
(
show subtarget assignments
)
8
purified
No
VC0072
81545617
Sensory box/GGDEF family protein
768
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
15.4%
Vibrio cholerae
IDP00200
(
show subtarget assignments
)
1
expressed
No
YPO1473
16121748
-
hypothetical protein
766
Virulence
Phase 1: October 2007
Yersinia pestis
Energy metabolism
Glycolysis/gluconeogenesis
IDP00193
(
show subtarget assignments
)
1
expressed
No
YPO0966
16121269
-
putative kinase
765
Virulence
Phase 1: October 2007
Yersinia pestis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP05014
(
show subtarget assignments
)
1
soluble
No
BA_1972
30256627
putative lipoprotein [Bacillus anthracis...
765
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP90172
(
show subtarget assignments
)
8
cloned
No
AAM13463.1
20153002
CPXV016 CDS
CPXV016 protein
764
ankyrin repeat protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP92020
(
show subtarget assignments
)
8
selected
No
TGME49_120640
237841247
cyclophilin, putative [Toxoplasma gondii...
764
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2A2N
15.3%
Toxoplasma gondii
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