Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00977 (show subtarget assignments)	1	expressed	No	STM1932	16765273	ftnB	ferritin-like protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1EUM	33.5%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP92017 (show subtarget assignments)	8	selected	No	ADC80544	289064337		glutamine aminoacyl-tRNA synthetase [Tox...	937	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1EUQ	31.2%	Toxoplasma gondii

IDP02831 (show subtarget assignments)	1	crystallized	No	GBAA4686	47529986	maf	Maf-like protein [Bacillus anthracis str...	191	Conserved; Drug target functions	Phase 3: June 2008	1EX2	53.4%	Bacillus anthracis	Cellular processes	Cell division

IDP00954 (show subtarget assignments)	1	in_crystallization_trials	No	STM1189	16764544	maf	Maf-like protein	194	Essential Gene	Phase 2: March 2008	1EX2	31.4%	Salmonella enterica	Cellular processes	Cell division

IDP01055 (show subtarget assignments)	1	crystallized	No	STM3371	16766666	maf	Maf-like protein	197	Conserved Gene / Pathway	Phase 2: March 2008	1EX2	43.7%	Salmonella enterica	Cellular processes	Cell division

IDP01327 (show subtarget assignments)	1	purified	No	VC0418	15640445	maf	Maf-like protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1EX2	40%	Vibrio cholerae	Cellular processes	Cell division

IDP91370 (show subtarget assignments)	8	expressed	No	VV1_2349	27365668		lactonizing lipase [Vibrio vulnificus CM...	302	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1EX9	55%	Vibrio vulnificus

IDP91777 (show subtarget assignments)	8	purified	No	AAC33914	3513664	sul1	Sul1 dihydropteroate synthase [Escherich...	279	drug resistance / Dihydropteroate synthase (sulfonamide resistance)	Community Requests	1EYE	35.1%	Escherichia coli

IDP01775 (show subtarget assignments)	1	cloned	No	Cj1331	15792654	ptmB	acylneuraminate cytidylyltransferase (fl...	235	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...	Phase 3: June 2008	1EYR	28.9%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02546 (show subtarget assignments)	1	expressed	No	Cj1143	15792468	neuA1	acylneuraminate cytidylyltransferase [Ca...	536	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	1EYR	16.2%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04418 (show subtarget assignments)	1	purified	No	FTT1767c	56708762	purT	phosphoribosylglycinamide formyltransfer...	386	conserved gene; putative drug target function;	Phase 4: April 2009	1EYZ	53.4%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02449 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1775	16122029	purT	phosphoribosylglycinamide formyltransfer...	393	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1EYZ	78.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00170 (show subtarget assignments)	1	soluble	No	VCA0865	15601620	hap	hemagglutinin/protease	609	Virulence	Phase 1: October 2007	1EZM	31.4%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP91737 (show subtarget assignments)	8	selected	No	Q5WMC9_ECOLX	0			550	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1F02	11.1%	Escherichia coli

IDP90202 (show subtarget assignments)	8	cloned	No	AAM13655.1	20153194	CPXV217 CDS	CPXV217 protein	372	serine-protease inhibitor (SPI-1)	Community Requests	1F0C	40.9%	Cowpox virus	host defense modulator	0

IDP90149 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_195.5	68449268		serine protease inhibitor-like SPI-1 pro...	357	similar to part of VACV-COP-C12L, MPXV-ZAI96-B19R	Community Requests	1F0C	42%	Monkeypox virus

IDP91032 (show subtarget assignments)	8	cloned	No	Y1069	31795399		toxin [Yersinia pestis KIM]	587	virulence/pathogenesis / survival factor of Y pestis in the flea	Community Requests	1F0I	22.7%	Yersinia pestis

IDP00674 (show subtarget assignments)	1	crystallized	No	SACOL1453	57286104	murG	N-acetylglucosaminyl transferase	356	Drug Target Function	Phase 2: March 2008	1F0K	25.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00596 (show subtarget assignments)	1	purified	No	YPO0555	16120883	murG	N-acetylglucosaminyl transferase	356	Drug Target Function	Phase 2: March 2008	1F0K	78.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01733 (show subtarget assignments)	1	cloned	No	FTT0811c	56707922	murG	UDP-N-acetylglucosamine--N-acetylmuramyl...	371	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1F0K	39.4%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02037 (show subtarget assignments)	1	cloned	No	CBU_0135	29540755	murG	UDP-N-acetylglucosamine--N-acetylmuramyl...	358	Conserved; Drug target functions	Phase 3: June 2008	1F0K	46.6%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01222 (show subtarget assignments)	1	purified	No	BA_4049	33301352		UDP-N-acetylglucosamine--N-acetylmuramyl...	364	Drug Target Function	Phase 2: March 2008	1F0K	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01453 (show subtarget assignments)	1	cloned	No	VC2401	15642398	murG	N-acetylglucosaminyl transferase	354	Conserved Gene / Pathway	Phase 2: March 2008	1F0K	63.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05101 (show subtarget assignments)	1	in_crystallization_trials	No	CD1058	126698642	hbd	3-hydroxybutyryl-CoA dehydrogenase [Clos...	281	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1F0Y	43.9%	Clostridium difficile	Fatty acid and phospholipid metabolism: Degradation

IDP01161 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4997	30259489		ABC transporter, ATP-binding protein	253	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	38.3%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01157 (show subtarget assignments)	1	expressed	No	BA_3749	60390552		Phosphonates import ATP-binding protein ...	257	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	36.6%	Bacillus anthracis	Transport and binding proteins	Other

IDP02762 (show subtarget assignments)	1	cloned	No	GBAA2482	47527772		ABC transporter ATP-binding protein [Bac...	256	Conserved; Drug target functions	Phase 3: June 2008	1F3O	40.6%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01158 (show subtarget assignments)	1	expressed	No	BA_4669	30259165		ABC transporter, ATP-binding protein	258	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	38%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP04042 (show subtarget assignments)	1	cloned	No	CPF_0296	110798725		putative cell division ATP-binding prote...	228	conserved gene; putative drug target function;	Phase 4: April 2009	1F3O	40.6%	Clostridium perfringens	Cellular processes	Cell division

IDP01862 (show subtarget assignments)	1	soluble	No	GBAA5510	47530828	tagH	teichoic acids export protein ATP-bindin...	549	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1F3O	12.4%	Bacillus anthracis	Transport and binding proteins	Other

IDP00709 (show subtarget assignments)	1	purified	No	SACOL0798	57285759		iron compound ABC transporter, ATP-bindi...	253	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	31.6%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP01425 (show subtarget assignments)	1	expressed	No	VC1630	15641635		ABC transporter, ATP-binding protein	227	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	37%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01156 (show subtarget assignments)	1	expressed	No	BA_0798	30254389		ABC transporter, ATP-binding protein	224	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	50.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02684 (show subtarget assignments)	1	cloned	No	FTT0405	56707554	lolD	lipoprotein releasing system, subunit D,...	231	Conserved; Drug target functions	Phase 3: June 2008	1F3O	44.6%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP04427 (show subtarget assignments)	1	expressed	No	GBAA4784	47530081		iron compound ABC transporter, ATP-bindi...	256	virulence factor; putative drug target function;	Phase 4: April 2009	1F3O	32.4%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00731 (show subtarget assignments)	1	purified	No	SACOL2462	57286457		ABC transporter, ATP-binding protein	220	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	35.5%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP00729 (show subtarget assignments)	1	purified	No	SACOL2356	57285089		ABC transporter, ATP-binding protein	221	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	37.1%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01760 (show subtarget assignments)	1	expressed	No	Cj1354	15792677	ceuD	enterochelin uptake ATP-binding protein ...	251	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1F3O	32.7%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01162 (show subtarget assignments)	1	expressed	No	BA_5496	30259957		ABC transporter, ATP-binding protein	226	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	54.4%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02070 (show subtarget assignments)	1	expressed	No	CBU_1809	29542365		ABC transporter, ATP-binding protein [Co...	221	Conserved; Drug target functions	Phase 3: June 2008	1F3O	49.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01781 (show subtarget assignments)	1	expressed	No	Cj1616	15792921	chuC	hemin ABC transporter, ATP-binding prote...	258	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1F3O	31.4%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00608 (show subtarget assignments)	1	expressed	No	SACOL0127	57285334		phosphonate ABC transporter, ATP-binding...	257	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	35%	Staphylococcus aureus	Transport and binding proteins	Other

IDP02687 (show subtarget assignments)	1	cloned	No	lmo2580	16804618		hypothetical protein lmo2580 [Listeria m...	222	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1F3O	46.8%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP02371 (show subtarget assignments)	1	expressed	No	CBU_1904	29542461	ftsE	cell division ABC transporter, ATP-bindi...	217	Conserved; Drug target functions	Phase 3: June 2008	1F3O	38.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01520 (show subtarget assignments)	1	expressed	No	VCA0782	15601537		ABC transporter, ATP-binding protein	225	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	46.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01424 (show subtarget assignments)	1	purified	No	VC1568	15641576		ABC transporter, ATP-binding protein	233	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	49.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP00921 (show subtarget assignments)	1	purified	No	STM0507	16763887	ybbA	putative ABC transporter ATP-binding pro...	228	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	42.5%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00705 (show subtarget assignments)	1	cloned	No	SACOL0306	57285419		ABC transporter, ATP-binding protein	225	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	39%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01468 (show subtarget assignments)	1	purified	No	VC2553	15642548		ABC transporter, ATP-binding protein, au...	238	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	32.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP90593 (show subtarget assignments)	8	soluble	No	YPO1522	16121795	metG	methionyl-tRNA synthetase [Yersinia pest...	675	Predicted Essential	Community Requests	1F4L	69.6%	Yersinia pestis

IDP90861 (show subtarget assignments)	8	selected	No	VC1036	15641049		methionyl-tRNA synthetase [Vibrio choler...	731	Predicted Essential	Community Requests	1F4L	57.7%	Vibrio cholerae

IDP05497 (show subtarget assignments)	1	cloned	No	CD0241	126697812		phosphoserine phosphatase [Clostridium d...	205	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1F5S	32.1%	Clostridium difficile	Amino acid biosynthesis: Serine family

IDP05522 (show subtarget assignments)	1	cloned	No	CD2240	126699857	nanA	N-acetylneuraminate lyase [Clostridium d...	302	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1F5Z	69.9%	Clostridium difficile	Central intermediary metabolism: Amino sugars

IDP01068 (show subtarget assignments)	0	work_stopped	No	STM3920	16767195	wecB	UDP-N-acetyl glucosamine-2-epimerase	376	Drug Target Function	Phase 2: March 2008	1F6D	85.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04151 (show subtarget assignments)	1	cloned	No	YPO3864	218930867	nfrC	UDP-N-acetylglucosamine 2-epimerase [Yer...	376	drug target; putative drug target function;	Phase 4: April 2009	1F6D	78.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05739 (show subtarget assignments)	1	cloned	No	CD2136	126699752	uppS	undecaprenyl pyrophosphate synthetase [C...	244	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1F75	52.9%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02157 (show subtarget assignments)	1	expressed	No	GBAA3961	47778228	uppS	undecaprenyl diphosphate synthase [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1F75	55.8%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04724 (show subtarget assignments)	1	cloned	No	YPO1415	115347174	pyrD	dihydroorotate dehydrogenase [Yersinia p...	336	conserved gene; putative drug target function;	Phase 4: April 2009	1F76	83.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90882 (show subtarget assignments)	8	cloned	No	VC1491	15641500		dihydroorotate dehydrogenase 2 [Vibrio c...	336	Predicted Essential	Community Requests	1F76	67.9%	Vibrio cholerae

IDP00357 (show subtarget assignments)	1	expressed	No	lmo0885	16802926	acpS	hypothetical protein lmo0885	118	Drug Target Function	Phase 2: March 2008	1F7L	50%	Listeria monocytogenes	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02295 (show subtarget assignments)	1	cloned	No	FTT1212c	56708274	gloA	lactoylglutathione lyase [Francisella tu...	127	Drug Target	Phase 3: June 2008	1F9Z	56.7%	Francisella tularensis	Energy metabolism	Other

IDP00990 (show subtarget assignments)	0	work_stopped	No	STM2193	16765523	folE	GTP cyclohydrolase I	222	Conserved Gene / Pathway	Phase 2: March 2008	1FBX	95.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP90588 (show subtarget assignments)	8	cloned	No	Q9KLX5	23821639		RecName: Full=GTP cyclohydrolase 1; AltN...	217	Predicted Essential	Community Requests	1FBX	70.5%	Vibrio cholerae

IDP02561 (show subtarget assignments)	1	purified	No	FTT0714c	56707833	kbl	2-amino-3-ketobutyrate coenzyme A ligase...	398	Conserved; Drug target functions	Phase 3: June 2008	1FC4	62.1%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP02210 (show subtarget assignments)	1	cloned	No	FTT0980	56708072		hypothetical protein FTT0980 [Francisell...	413	Conserved; Drug target functions	Phase 3: June 2008	1FC4	26.4%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP00580 (show subtarget assignments)	1	purified	No	YPO0059	16120412	kbl	2-amino-3-ketobutyrate coenzyme A ligase...	403	Conserved Gene / Pathway	Phase 2: March 2008	1FC4	82.9%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00941 (show subtarget assignments)	1	purified	No	STM0846	16764208	moeA	molybdopterin biosynthesis protein MoeA ...	413	Conserved Gene / Pathway	Phase 2: March 2008	1FC5	87.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP01420 (show subtarget assignments)	1	cloned	No	VC1496	15641505		carboxy-terminal protease	665	Drug Target Function	Phase 2: March 2008	1FC6	16.1%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00205 (show subtarget assignments)	1	cloned	No	YPO1705	16121965	-	tail-specific protease precursor	690	Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...	Phase 1: October 2007	1FC6	15.8%	Yersinia pestis

IDP01804 (show subtarget assignments)	1	cloned	No	GBAA5414	47530727		carboxyl-terminal protease [Bacillus ant...	469	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FC6	19.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00675 (show subtarget assignments)	1	cloned	No	SACOL1455	57284564		carboxyl-terminal protease	496	Drug Target Function	Phase 2: March 2008	1FC6	20%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91338 (show subtarget assignments)	8	expressed	No	VV2_0132	27366588		cytochrome c553 [Vibrio vulnificus CMCP6...	207	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1FCD	27.5%	Vibrio vulnificus

IDP90762 (show subtarget assignments)	8	in_crystallization_trials	No	VC0968	15640984		cysteine synthase A [Vibrio cholerae O1 ...	322	Predicted Essential	Community Requests	1FCJ	79.2%	Vibrio cholerae

IDP91061 (show subtarget assignments)	8	purified	No	YPO3532	16123678	fklB	FKBP-type peptidyl-prolyl cis-trans isom...	206	virulence/pathogenesis / Gene encodes a Mip orthologue which has shown to be important for virulence in v...	Community Requests	1FD9	38.8%	Yersinia pestis

IDP01085 (show subtarget assignments)	1	in_crystallization_trials	No	STM4397	161353572	fklB	FKBP-type 22KD peptidyl-prolyl cis-trans...	206	Conserved Gene / Pathway	Phase 2: March 2008	1FD9	40.3%	Salmonella enterica	Protein synthesis	Translation factors

IDP01469 (show subtarget assignments)	1	purified	No	VC2568	15642563		peptidyl-prolyl cis-trans isomerase, FKB...	209	Conserved Gene / Pathway	Phase 2: March 2008	1FD9	40.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP02121 (show subtarget assignments)	1	cloned	No	FTT0360	56707511		Short-chain dehydrogenase/reductase [Fra...	274	Drug Target	Phase 3: June 2008	1FDW	27.7%	Francisella tularensis	Central intermediary metabolism	Other

IDP05047 (show subtarget assignments)	1	soluble	No	BA_4154	30258660	ctaC	cytochrome c oxidase, subunit II [Bacill...	349	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1FFT	19.2%	Bacillus anthracis	Energy metabolism: Electron transport

IDP02304 (show subtarget assignments)	1	cloned	No	GBAA0703	47525984	qoxA	quinol oxidase, subunit II [Bacillus ant...	291	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FFT	33.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP90764 (show subtarget assignments)	8	purified	No	STM0046	16763436	ileS	isoleucyl-tRNA synthetase [Salmonella ty...	944	Predicted Essential	Community Requests	1FFY	42.2%	Salmonella enterica

IDP04368 (show subtarget assignments)	1	selected	No	BAS3746	49186745		isoleucyl-tRNA synthetase [Bacillus anth...	921	Proposed to be essential proteins	Phase 4: April 2009	1FFY	63.3%	Bacillus anthracis

IDP90911 (show subtarget assignments)	8	soluble	No	YPO0475	16120804	ileS	isoleucyl-tRNA synthetase [Yersinia pest...	938	Predicted Essential	Community Requests	1FFY	43.2%	Yersinia pestis

IDP05693 (show subtarget assignments)	1	soluble	No	lmo2019	16804058	ileS	isoleucyl-tRNA synthetase [Listeria mono...	921	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1FFY	61.4%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP90823 (show subtarget assignments)	8	soluble	No	VC0682	15640701	ileS	isoleucyl-tRNA synthetase [Vibrio choler...	949	Predicted Essential	Community Requests	1FFY	43.1%	Vibrio cholerae

IDP90761 (show subtarget assignments)	8	cloned	No	Cj1061c	15792388	ileS	isoleucyl-tRNA synthetase [Campylobacter...	917	Predicted Essential	Community Requests	1FFY	38.8%	Campylobacter jejuni

IDP00984 (show subtarget assignments)	1	in_crystallization_trials	No	STM2073	16765403	hisC	histidinol-phosphate aminotransferase	359	Conserved Gene / Pathway	Phase 2: March 2008	1FG3	88%	Salmonella enterica	Amino acid biosynthesis	Histidine family

IDP04159 (show subtarget assignments)	1	cloned	No	VC1134	15641147		histidinol-phosphate aminotransferase [V...	346	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1FG3	59.8%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP05745 (show subtarget assignments)	1	expressed	No	CD2787	126700403	cwp84	cell surface protein (putative cell surf...	803	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1FH0	8.2%	Clostridium difficile	Cell envelope: Other

IDP90609 (show subtarget assignments)	8	in_crystallization_trials	No	VC1972	15641974		O-succinylbenzoate synthase [Vibrio chol...	332	Predicted Essential	Community Requests	1FHU	54.2%	Vibrio cholerae

IDP91815 (show subtarget assignments)	8	soluble	No	b3956	1790393	ppc	phosphoenolpyruvate carboxylase [Escheri...	883	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1FIY	100%	Escherichia coli

IDP01809 (show subtarget assignments)	1	purified	No	FTT0258	56707414		carboxylesterase/phospholipase family pr...	222	Drug Target	Phase 3: June 2008	1FJ2	39.6%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP02404 (show subtarget assignments)	1	cloned	No	GBAA2730	47528021		neutral protease [Bacillus anthracis str...	567	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	1FJ3	25.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02702 (show subtarget assignments)	1	cloned	No	GBAA3442	47528726		neutral protease [Bacillus anthracis str...	565	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	1FJ3	24.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91302 (show subtarget assignments)	8	soluble	No	STM2378	16765705	fabB	3-oxoacyl-(acyl carrier protein) synthas...	404	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1FJ4	96.8%	Salmonella enterica

IDP91287 (show subtarget assignments)	8	soluble	No	SPA0486	56412725	fabB	3-oxoacyl-(acyl carrier protein) synthas...	404	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1FJ4	96.8%	Salmonella enterica

IDP04589 (show subtarget assignments)	1	expressed	No	BAS0135	49183169		30S ribosomal protein S13 [Bacillus anth...	121	Proposed to be essential proteins	Phase 4: April 2009	1FJG	63.9%	Bacillus anthracis

IDP04080 (show subtarget assignments)	1	cloned	No	BAS0123	49183157		30S ribosomal protein S14 [Bacillus anth...	61	Proposed to be essential proteins	Phase 4: April 2009	1FJG	73.8%	Bacillus anthracis

IDP04708 (show subtarget assignments)	1	purified	No	BAS0114	49183148		30S ribosomal protein S19 [Bacillus anth...	92	Proposed to be essential proteins	Phase 4: April 2009	1FJG	66.3%	Bacillus anthracis

IDP04604 (show subtarget assignments)	1	cloned	No	BAS3678	49186677		30S ribosomal protein S2 [Bacillus anthr...	233	Proposed to be essential proteins	Phase 4: April 2009	1FJG	56.2%	Bacillus anthracis

IDP02513 (show subtarget assignments)	1	soluble	No	GBAA0258	47525517		hypothetical protein GBAA0258 [Bacillus ...	157	Conserved;	Phase 3: June 2008	1FL9	30.6%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP00977
(show subtarget assignments)

1

expressed

No

STM1932

16765273

ftnB

ferritin-like protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1EUM

33.5%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP92017
(show subtarget assignments)

8

selected

No

ADC80544

289064337

glutamine aminoacyl-tRNA synthetase [Tox...

937

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1EUQ

31.2%

Toxoplasma gondii

IDP02831
(show subtarget assignments)

1

crystallized

No

GBAA4686

47529986

maf

Maf-like protein [Bacillus anthracis str...

191

Conserved; Drug target functions

Phase 3: June 2008

1EX2

53.4%

Bacillus anthracis

Cellular processes

Cell division

IDP00954
(show subtarget assignments)

1

in_crystallization_trials

No

STM1189

16764544

maf

Maf-like protein

194

Essential Gene

Phase 2: March 2008

1EX2

31.4%

Salmonella enterica

Cellular processes

Cell division

IDP01055
(show subtarget assignments)

1

crystallized

No

STM3371

16766666

maf

Maf-like protein

197

Conserved Gene / Pathway

Phase 2: March 2008

1EX2

43.7%

Salmonella enterica

Cellular processes

Cell division

IDP01327
(show subtarget assignments)

1

purified

No

VC0418

15640445

maf

Maf-like protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1EX2

40%

Vibrio cholerae

Cellular processes

Cell division

IDP91370
(show subtarget assignments)

8

expressed

No

VV1_2349

27365668

lactonizing lipase [Vibrio vulnificus CM...

302

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1EX9

55%

Vibrio vulnificus

IDP91777
(show subtarget assignments)

8

purified

No

AAC33914

3513664

sul1

Sul1 dihydropteroate synthase [Escherich...

279

drug resistance / Dihydropteroate synthase (sulfonamide resistance)

Community Requests

1EYE

35.1%

Escherichia coli

IDP01775
(show subtarget assignments)

1

cloned

No

Cj1331

15792654

ptmB

acylneuraminate cytidylyltransferase (fl...

235

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...

Phase 3: June 2008

1EYR

28.9%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02546
(show subtarget assignments)

1

expressed

No

Cj1143

15792468

neuA1

acylneuraminate cytidylyltransferase [Ca...

536

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

1EYR

16.2%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04418
(show subtarget assignments)

1

purified

No

FTT1767c

56708762

purT

phosphoribosylglycinamide formyltransfer...

386

conserved gene; putative drug target function;

Phase 4: April 2009

1EYZ

53.4%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02449
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1775

16122029

purT

phosphoribosylglycinamide formyltransfer...

393

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1EYZ

78.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00170
(show subtarget assignments)

1

soluble

No

VCA0865

15601620

hap

hemagglutinin/protease

609

Virulence

Phase 1: October 2007

1EZM

31.4%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP91737
(show subtarget assignments)

8

selected

No

Q5WMC9_ECOLX

0

550

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1F02

11.1%

Escherichia coli

IDP90202
(show subtarget assignments)

8

cloned

No

AAM13655.1

20153194

CPXV217 CDS

CPXV217 protein

372

serine-protease inhibitor (SPI-1)

Community Requests

1F0C

40.9%

Cowpox virus

host defense modulator

0

IDP90149
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_195.5

68449268

serine protease inhibitor-like SPI-1 pro...

357

Community Requests

1F0C

42%

Monkeypox virus

IDP91032
(show subtarget assignments)

8

cloned

No

Y1069

31795399

toxin [Yersinia pestis KIM]

587

virulence/pathogenesis / survival factor of Y pestis in the flea

Community Requests

1F0I

22.7%

Yersinia pestis

IDP00674
(show subtarget assignments)

1

crystallized

No

SACOL1453

57286104

murG

N-acetylglucosaminyl transferase

356

Drug Target Function

Phase 2: March 2008

1F0K

25.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00596
(show subtarget assignments)

1

purified

No

YPO0555

16120883

murG

N-acetylglucosaminyl transferase

356

Drug Target Function

Phase 2: March 2008

1F0K

78.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01733
(show subtarget assignments)

1

cloned

No

FTT0811c

56707922

murG

UDP-N-acetylglucosamine--N-acetylmuramyl...

371

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1F0K

39.4%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02037
(show subtarget assignments)

1

cloned

No

CBU_0135

29540755

murG

UDP-N-acetylglucosamine--N-acetylmuramyl...

358

Conserved; Drug target functions

Phase 3: June 2008

1F0K

46.6%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01222
(show subtarget assignments)

1

purified

No

BA_4049

33301352

UDP-N-acetylglucosamine--N-acetylmuramyl...

364

Drug Target Function

Phase 2: March 2008

1F0K

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01453
(show subtarget assignments)

1

cloned

No

VC2401

15642398

murG

N-acetylglucosaminyl transferase

354

Conserved Gene / Pathway

Phase 2: March 2008

1F0K

63.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05101
(show subtarget assignments)

1

in_crystallization_trials

No

CD1058

126698642

hbd

3-hydroxybutyryl-CoA dehydrogenase [Clos...

281

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1F0Y

43.9%

Clostridium difficile

Fatty acid and phospholipid metabolism: Degradation

IDP01161
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4997

30259489

ABC transporter, ATP-binding protein

253

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

38.3%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01157
(show subtarget assignments)

1

expressed

No

BA_3749

60390552

Phosphonates import ATP-binding protein ...

257

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

36.6%

Bacillus anthracis

Transport and binding proteins

Other

IDP02762
(show subtarget assignments)

1

cloned

No

GBAA2482

47527772

ABC transporter ATP-binding protein [Bac...

256

Conserved; Drug target functions

Phase 3: June 2008

1F3O

40.6%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01158
(show subtarget assignments)

1

expressed

No

BA_4669

30259165

ABC transporter, ATP-binding protein

258

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

38%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP04042
(show subtarget assignments)

1

cloned

No

CPF_0296

110798725

putative cell division ATP-binding prote...

228

conserved gene; putative drug target function;

Phase 4: April 2009

1F3O

40.6%

Clostridium perfringens

Cellular processes

Cell division

IDP01862
(show subtarget assignments)

1

soluble

No

GBAA5510

47530828

tagH

teichoic acids export protein ATP-bindin...

549

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1F3O

12.4%

Bacillus anthracis

Transport and binding proteins

Other

IDP00709
(show subtarget assignments)

1

purified

No

SACOL0798

57285759

iron compound ABC transporter, ATP-bindi...

253

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

31.6%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP01425
(show subtarget assignments)

1

expressed

No

VC1630

15641635

ABC transporter, ATP-binding protein

227

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

37%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01156
(show subtarget assignments)

1

expressed

No

BA_0798

30254389

ABC transporter, ATP-binding protein

224

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

50.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02684
(show subtarget assignments)

1

cloned

No

FTT0405

56707554

lolD

lipoprotein releasing system, subunit D,...

231

Conserved; Drug target functions

Phase 3: June 2008

1F3O

44.6%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP04427
(show subtarget assignments)

1

expressed

No

GBAA4784

47530081

iron compound ABC transporter, ATP-bindi...

256

virulence factor; putative drug target function;

Phase 4: April 2009

1F3O

32.4%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00731
(show subtarget assignments)

1

purified

No

SACOL2462

57286457

ABC transporter, ATP-binding protein

220

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

35.5%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP00729
(show subtarget assignments)

1

purified

No

SACOL2356

57285089

ABC transporter, ATP-binding protein

221

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

37.1%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01760
(show subtarget assignments)

1

expressed

No

Cj1354

15792677

ceuD

enterochelin uptake ATP-binding protein ...

251

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1F3O

32.7%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01162
(show subtarget assignments)

1

expressed

No

BA_5496

30259957

ABC transporter, ATP-binding protein

226

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

54.4%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02070
(show subtarget assignments)

1

expressed

No

CBU_1809

29542365

ABC transporter, ATP-binding protein [Co...

221

Conserved; Drug target functions

Phase 3: June 2008

1F3O

49.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01781
(show subtarget assignments)

1

expressed

No

Cj1616

15792921

chuC

hemin ABC transporter, ATP-binding prote...

258

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1F3O

31.4%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00608
(show subtarget assignments)

1

expressed

No

SACOL0127

57285334

phosphonate ABC transporter, ATP-binding...

257

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

35%

Staphylococcus aureus

Transport and binding proteins

Other

IDP02687
(show subtarget assignments)

1

cloned

No

lmo2580

16804618

hypothetical protein lmo2580 [Listeria m...

222

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1F3O

46.8%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP02371
(show subtarget assignments)

1

expressed

No

CBU_1904

29542461

ftsE

cell division ABC transporter, ATP-bindi...

217

Conserved; Drug target functions

Phase 3: June 2008

1F3O

38.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01520
(show subtarget assignments)

1

expressed

No

VCA0782

15601537

ABC transporter, ATP-binding protein

225

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

46.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01424
(show subtarget assignments)

1

purified

No

VC1568

15641576

ABC transporter, ATP-binding protein

233

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

49.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP00921
(show subtarget assignments)

1

purified

No

STM0507

16763887

ybbA

putative ABC transporter ATP-binding pro...

228

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

42.5%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00705
(show subtarget assignments)

1

cloned

No

SACOL0306

57285419

ABC transporter, ATP-binding protein

225

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

39%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01468
(show subtarget assignments)

1

purified

No

VC2553

15642548

ABC transporter, ATP-binding protein, au...

238

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

32.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP90593
(show subtarget assignments)

8

soluble

No

YPO1522

16121795

metG

methionyl-tRNA synthetase [Yersinia pest...

675

Predicted Essential

Community Requests

1F4L

69.6%

Yersinia pestis

IDP90861
(show subtarget assignments)

8

selected

No

VC1036

15641049

methionyl-tRNA synthetase [Vibrio choler...

731

Predicted Essential

Community Requests

1F4L

57.7%

Vibrio cholerae

IDP05497
(show subtarget assignments)

1

cloned

No

CD0241

126697812

phosphoserine phosphatase [Clostridium d...

205

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1F5S

32.1%

Clostridium difficile

Amino acid biosynthesis: Serine family

IDP05522
(show subtarget assignments)

1

cloned

No

CD2240

126699857

nanA

N-acetylneuraminate lyase [Clostridium d...

302

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1F5Z

69.9%

Clostridium difficile

Central intermediary metabolism: Amino sugars

IDP01068
(show subtarget assignments)

0

work_stopped

No

STM3920

16767195

wecB

UDP-N-acetyl glucosamine-2-epimerase

376

Drug Target Function

Phase 2: March 2008

1F6D

85.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04151
(show subtarget assignments)

1

cloned

No

YPO3864

218930867

nfrC

UDP-N-acetylglucosamine 2-epimerase [Yer...

376

drug target; putative drug target function;

Phase 4: April 2009

1F6D

78.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05739
(show subtarget assignments)

1

cloned

No

CD2136

126699752

uppS

undecaprenyl pyrophosphate synthetase [C...

244

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1F75

52.9%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02157
(show subtarget assignments)

1

expressed

No

GBAA3961

47778228

uppS

undecaprenyl diphosphate synthase [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1F75

55.8%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04724
(show subtarget assignments)

1

cloned

No

YPO1415

115347174

pyrD

dihydroorotate dehydrogenase [Yersinia p...

336

conserved gene; putative drug target function;

Phase 4: April 2009

1F76

83.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90882
(show subtarget assignments)

8

cloned

No

VC1491

15641500

dihydroorotate dehydrogenase 2 [Vibrio c...

336

Predicted Essential

Community Requests

1F76

67.9%

Vibrio cholerae

IDP00357
(show subtarget assignments)

1

expressed

No

lmo0885

16802926

acpS

hypothetical protein lmo0885

118

Drug Target Function

Phase 2: March 2008

1F7L

50%

Listeria monocytogenes

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02295
(show subtarget assignments)

1

cloned

No

FTT1212c

56708274

gloA

lactoylglutathione lyase [Francisella tu...

127

Drug Target

Phase 3: June 2008

1F9Z

56.7%

Francisella tularensis

Energy metabolism

Other

IDP00990
(show subtarget assignments)

0

work_stopped

No

STM2193

16765523

folE

GTP cyclohydrolase I

222

Conserved Gene / Pathway

Phase 2: March 2008

1FBX

95.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP90588
(show subtarget assignments)

8

cloned

No

Q9KLX5

23821639

RecName: Full=GTP cyclohydrolase 1; AltN...

217

Predicted Essential

Community Requests

1FBX

70.5%

Vibrio cholerae

IDP02561
(show subtarget assignments)

1

purified

No

FTT0714c

56707833

kbl

2-amino-3-ketobutyrate coenzyme A ligase...

398

Conserved; Drug target functions

Phase 3: June 2008

1FC4

62.1%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP02210
(show subtarget assignments)

1

cloned

No

FTT0980

56708072

hypothetical protein FTT0980 [Francisell...

413

Conserved; Drug target functions

Phase 3: June 2008

1FC4

26.4%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP00580
(show subtarget assignments)

1

purified

No

YPO0059

16120412

kbl

2-amino-3-ketobutyrate coenzyme A ligase...

403

Conserved Gene / Pathway

Phase 2: March 2008

1FC4

82.9%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00941
(show subtarget assignments)

1

purified

No

STM0846

16764208

moeA

molybdopterin biosynthesis protein MoeA ...

413

Conserved Gene / Pathway

Phase 2: March 2008

1FC5

87.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP01420
(show subtarget assignments)

1

cloned

No

VC1496

15641505

carboxy-terminal protease

665

Drug Target Function

Phase 2: March 2008

1FC6

16.1%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00205
(show subtarget assignments)

1

cloned

No

YPO1705

16121965

-

tail-specific protease precursor

690

Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...

Phase 1: October 2007

1FC6

15.8%

Yersinia pestis

IDP01804
(show subtarget assignments)

1

cloned

No

GBAA5414

47530727

carboxyl-terminal protease [Bacillus ant...

469

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FC6

19.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00675
(show subtarget assignments)

1

cloned

No

SACOL1455

57284564

carboxyl-terminal protease

496

Drug Target Function

Phase 2: March 2008

1FC6

20%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91338
(show subtarget assignments)

8

expressed

No

VV2_0132

27366588

cytochrome c553 [Vibrio vulnificus CMCP6...

207

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1FCD

27.5%

Vibrio vulnificus

IDP90762
(show subtarget assignments)

8

in_crystallization_trials

No

VC0968

15640984

cysteine synthase A [Vibrio cholerae O1 ...

322

Predicted Essential

Community Requests

1FCJ

79.2%

Vibrio cholerae

IDP91061
(show subtarget assignments)

8

purified

No

YPO3532

16123678

fklB

FKBP-type peptidyl-prolyl cis-trans isom...

206

virulence/pathogenesis / Gene encodes a Mip orthologue which has shown to be important for virulence in v...

Community Requests

1FD9

38.8%

Yersinia pestis

IDP01085
(show subtarget assignments)

1

in_crystallization_trials

No

STM4397

161353572

fklB

FKBP-type 22KD peptidyl-prolyl cis-trans...

206

Conserved Gene / Pathway

Phase 2: March 2008

1FD9

40.3%

Salmonella enterica

Protein synthesis

Translation factors

IDP01469
(show subtarget assignments)

1

purified

No

VC2568

15642563

peptidyl-prolyl cis-trans isomerase, FKB...

209

Conserved Gene / Pathway

Phase 2: March 2008

1FD9

40.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP02121
(show subtarget assignments)

1

cloned

No

FTT0360

56707511

Short-chain dehydrogenase/reductase [Fra...

274

Drug Target

Phase 3: June 2008

1FDW

27.7%

Francisella tularensis

Central intermediary metabolism

Other

IDP05047
(show subtarget assignments)

1

soluble

No

BA_4154

30258660

ctaC

cytochrome c oxidase, subunit II [Bacill...

349

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1FFT

19.2%

Bacillus anthracis

Energy metabolism: Electron transport

IDP02304
(show subtarget assignments)

1

cloned

No

GBAA0703

47525984

qoxA

quinol oxidase, subunit II [Bacillus ant...

291

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FFT

33.7%

Bacillus anthracis

Energy metabolism

Electron transport

IDP90764
(show subtarget assignments)

8

purified

No

STM0046

16763436

ileS

isoleucyl-tRNA synthetase [Salmonella ty...

944

Predicted Essential

Community Requests

1FFY

42.2%

Salmonella enterica

IDP04368
(show subtarget assignments)

1

selected

No

BAS3746

49186745

isoleucyl-tRNA synthetase [Bacillus anth...

921

Proposed to be essential proteins

Phase 4: April 2009

1FFY

63.3%

Bacillus anthracis

IDP90911
(show subtarget assignments)

8

soluble

No

YPO0475

16120804

ileS

isoleucyl-tRNA synthetase [Yersinia pest...

938

Predicted Essential

Community Requests

1FFY

43.2%

Yersinia pestis

IDP05693
(show subtarget assignments)

1

soluble

No

lmo2019

16804058

ileS

isoleucyl-tRNA synthetase [Listeria mono...

921

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1FFY

61.4%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP90823
(show subtarget assignments)

8

soluble

No

VC0682

15640701

ileS

isoleucyl-tRNA synthetase [Vibrio choler...

949

Predicted Essential

Community Requests

1FFY

43.1%

Vibrio cholerae

IDP90761
(show subtarget assignments)

8

cloned

No

Cj1061c

15792388

ileS

isoleucyl-tRNA synthetase [Campylobacter...

917

Predicted Essential

Community Requests

1FFY

38.8%

Campylobacter jejuni

IDP00984
(show subtarget assignments)

1

in_crystallization_trials

No

STM2073

16765403

hisC

histidinol-phosphate aminotransferase

359

Conserved Gene / Pathway

Phase 2: March 2008

1FG3

88%

Salmonella enterica

Amino acid biosynthesis

Histidine family

IDP04159
(show subtarget assignments)

1

cloned

No

VC1134

15641147

histidinol-phosphate aminotransferase [V...

346

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1FG3

59.8%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP05745
(show subtarget assignments)

1

expressed

No

CD2787

126700403

cwp84

cell surface protein (putative cell surf...

803

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1FH0

8.2%

Clostridium difficile

Cell envelope: Other

IDP90609
(show subtarget assignments)

8

in_crystallization_trials

No

VC1972

15641974

O-succinylbenzoate synthase [Vibrio chol...

332

Predicted Essential

Community Requests

1FHU

54.2%

Vibrio cholerae

IDP91815
(show subtarget assignments)

8

soluble

No

b3956

1790393

ppc

phosphoenolpyruvate carboxylase [Escheri...

883

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1FIY

100%

Escherichia coli

IDP01809
(show subtarget assignments)

1

purified

No

FTT0258

56707414

carboxylesterase/phospholipase family pr...

222

Drug Target

Phase 3: June 2008

1FJ2

39.6%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP02404
(show subtarget assignments)

1

cloned

No

GBAA2730

47528021

neutral protease [Bacillus anthracis str...

567

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

1FJ3

25.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02702
(show subtarget assignments)

1

cloned

No

GBAA3442

47528726

neutral protease [Bacillus anthracis str...

565

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

1FJ3

24.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91302
(show subtarget assignments)

8

soluble

No

STM2378

16765705

fabB

3-oxoacyl-(acyl carrier protein) synthas...

404

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1FJ4

96.8%

Salmonella enterica

IDP91287
(show subtarget assignments)

8

soluble

No

SPA0486

56412725

fabB

3-oxoacyl-(acyl carrier protein) synthas...

404

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1FJ4

96.8%

Salmonella enterica

IDP04589
(show subtarget assignments)

1

expressed

No

BAS0135

49183169

30S ribosomal protein S13 [Bacillus anth...

121

Proposed to be essential proteins

Phase 4: April 2009

1FJG

63.9%

Bacillus anthracis

IDP04080
(show subtarget assignments)

1

cloned

No

BAS0123

49183157

30S ribosomal protein S14 [Bacillus anth...

61

Proposed to be essential proteins

Phase 4: April 2009

1FJG

73.8%

Bacillus anthracis

IDP04708
(show subtarget assignments)

1

purified

No

BAS0114

49183148

30S ribosomal protein S19 [Bacillus anth...

92

Proposed to be essential proteins

Phase 4: April 2009

1FJG

66.3%

Bacillus anthracis

IDP04604
(show subtarget assignments)

1

cloned

No

BAS3678

49186677

30S ribosomal protein S2 [Bacillus anthr...

233

Proposed to be essential proteins

Phase 4: April 2009

1FJG

56.2%

Bacillus anthracis

IDP02513
(show subtarget assignments)

1

soluble

No

GBAA0258

47525517

hypothetical protein GBAA0258 [Bacillus ...

157

Conserved;

Phase 3: June 2008

1FL9

30.6%

Bacillus anthracis

Hypothetical proteins

Conserved