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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 5 of 60, showing 100 records out of 5973 total, starting on record 401
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP04289
(
show subtarget assignments
)
1
expressed
No
YPCD1.35c
16082723
yscY
hypothetical protein YPCD1.35c [Yersinia...
114
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP91605
(
show subtarget assignments
)
8
cloned
No
CBU_1825
29542381
hypothetical protein
115
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP02540
(
show subtarget assignments
)
1
cloned
No
CBU_1584
29542144
shaE
monovalent cation/proton antiporter subu...
115
Conserved; Drug target functions
Phase 3: June 2008
Coxiella burnetii
Transport and binding proteins
Cations and iron carrying compounds
IDP91622
(
show subtarget assignments
)
8
expressed
No
BAB35650
13361693
ECs2227
hypothetical protein [Escherichia coli O...
115
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91459
(
show subtarget assignments
)
8
soluble
No
VV1_0096
27363580
dTDP-glucose pyrophosphorylase [Vibrio v...
115
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP00458
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO2680
16122885
celC
N,N'-diacetylchitobiose-specific PTS sys...
115
Conserved Gene / Pathway
Phase 2: March 2008
1WCR
67%
Yersinia pestis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP01083
(
show subtarget assignments
)
1
in_pdb
3OPK
No
STM4324
16767573
cutA
divalent-cation tolerance protein CutA
115
Conserved Gene / Pathway
Phase 2: March 2008
3OPK
100%
Salmonella enterica
Cellular processes
Detoxification
IDP90213
(
show subtarget assignments
)
8
purified
No
MYXV_gp033
9633665
m029L
m029L, m29L
115
IFN resistance, PKR inhibitor
Community Requests
2YT4
19.1%
Myxoma virus
host range factor, host defense modulator
0
IDP05544
(
show subtarget assignments
)
1
purified
No
Cj1409
6968828
acpS
putative Ni/Fe-hydrogenase small subunit...
115
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3HYK
39.5%
Campylobacter jejuni
Fatty acid and phospholipid metabolism: Biosynthesis
IDP00406
(
show subtarget assignments
)
1
cloned
No
YPO3410
16123559
hypothetical protein YPO3410
115
Virulence Associated Factor
Phase 2: March 2008
3UTK
26.1%
Yersinia pestis
Cell envelope
Other
IDP04570
(
show subtarget assignments
)
1
soluble
No
FTT0153
56707323
rplS
50S ribosomal protein L19 [Francisella t...
115
drug target; conserved gene;
Phase 4: April 2009
1VS6
58.3%
Francisella tularensis
Protein synthesis
Ribosomal proteins: synthesis and modification
IDP05672
(
show subtarget assignments
)
1
soluble
No
lmo0778
16802820
-
hypothetical protein lmo0778 [Listeria m...
115
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP00105
(
show subtarget assignments
)
1
purified
No
NT01SF3662
30042589
S3225
putative class II aminotransferase
116
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2X8U
40.5%
Shigella flexneri
Central intermediary metabolism
Other
IDP91754
(
show subtarget assignments
)
8
selected
No
TVB1_HUMAN
0
116
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3UTP
80.2%
Homo sapiens
IDP00884
(
show subtarget assignments
)
1
purified
No
STM1925
16765267
flhD
transcriptional activator FlhD
116
Conserved Gene / Pathway
Phase 2: March 2008
1G8E
89.7%
Salmonella enterica
Cell envelope
Surface structures
IDP05120
(
show subtarget assignments
)
1
in_crystallization_trials
No
CD0236
126697807
fliS2
flagellar protein [Clostridium difficile...
116
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1VH6
26.7%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP90373
(
show subtarget assignments
)
8
expressed
No
CT_191
3328596
hypothetical protein [Chlamydia trachoma...
116
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01300
(
show subtarget assignments
)
1
in_pdb
3F0I
Yes
VC2165
15642164
arsenate reductase
116
Conserved Gene / Pathway
Phase 2: March 2008
3F0I
100%
Vibrio cholerae
Cellular processes
Detoxification
IDP05642
(
show subtarget assignments
)
1
cloned
No
CD3294
126700913
putative type IV pilin [Clostridium diff...
116
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Cell envelope: Surface structures
IDP01509
(
show subtarget assignments
)
1
expressed
No
VC0549
15640571
oxaloacetate decarboxylase subunit gamma...
117
Drug Target Function
Phase 2: March 2008
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP05046
(
show subtarget assignments
)
1
expressed
No
BA_3529
30258064
hypothetical protein BA_3529 [Bacillus a...
117
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP90117
(
show subtarget assignments
)
8
in_crystallization_trials
No
MPXV_ZAI1979_005_027
68449101
virokine protein [Monkeypox virus]
117
similar to VACV-COP-N1L, MPXV-ZAI96-P1L
Community Requests
2I39
89.7%
Monkeypox virus
IDP01315
(
show subtarget assignments
)
1
cloned
No
VC0942
15640958
hypothetical protein VC0942
117
Conserved Gene / Pathway
Phase 2: March 2008
Vibrio cholerae
Cell envelope
Other
IDP02691
(
show subtarget assignments
)
1
purified
No
FTT0943c
56708040
folB
dihydroneopterin aldolase [Francisella t...
117
Drug Target
Phase 3: June 2008
1SQL
28.2%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Folic acid
IDP04114
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1611
115347358
conserved hypothetical protein [Yersinia...
117
drug target; conserved gene;
Phase 4: April 2009
3N1S
84.6%
Yersinia pestis
Unknown function
General
IDP01783
(
show subtarget assignments
)
1
expressed
No
FTT0824
56707935
arsC1
arsenate reductase [Francisella tularens...
117
Drug Target
Phase 3: June 2008
3GKX
25.6%
Francisella tularensis
Unknown function
General
IDP01722
(
show subtarget assignments
)
1
soluble
No
STM1881
16765223
yebF
hypothetical protein STM1881 [Salmonella...
117
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP05476
(
show subtarget assignments
)
1
soluble
No
BA_2745
30257350
putative lipoprotein [Bacillus anthracis...
117
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP90505
(
show subtarget assignments
)
8
soluble
No
YPO0231
16120569
rpsM
30S ribosomal protein S13
118
Predicted Essential
Community Requests
1VS5
85.6%
Yersinia pestis
IDP00841
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL0876
57284336
arsenate reductase, putative
118
Conserved Gene / Pathway
Phase 2: March 2008
3FZ4
41.5%
Staphylococcus aureus
Cellular processes
Detoxification
IDP90504
(
show subtarget assignments
)
8
purified
No
VC0006
15640038
rnpA
ribonuclease P [Vibrio cholerae O1 biova...
118
Predicted Essential
Community Requests
2LJP
54.2%
Vibrio cholerae
IDP01771
(
show subtarget assignments
)
1
cloned
No
YPO1786
16122040
hypothetical protein YPO1786 [Yersinia p...
118
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
Yersinia pestis
Cell envelope
Other
IDP00581
(
show subtarget assignments
)
1
in_pdb
3RDW
Yes
YPO3070
16123247
putative arsenate reductase
118
Virulence Associated Factor
Phase 2: March 2008
3RDW
100%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP91705
(
show subtarget assignments
)
8
selected
No
NP_004879
4757818
ATP6V1G1
V-type proton ATPase subunit G 1 [Homo s...
118
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2K88
27.1%
Homo sapiens
IDP01017
(
show subtarget assignments
)
1
expressed
No
STM2854
16766160
hypA
hydrogenase nickel incorporation protein...
118
Conserved Gene / Pathway
Phase 2: March 2008
3A43
24.6%
Salmonella enterica
Protein fate
Protein modification and repair
IDP00357
(
show subtarget assignments
)
1
expressed
No
lmo0885
16802926
acpS
hypothetical protein lmo0885
118
Drug Target Function
Phase 2: March 2008
1F7L
50%
Listeria monocytogenes
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00626
(
show subtarget assignments
)
1
cloned
No
SACOL2506
57285191
sarT
staphylococcal accessory regulator T
118
Conserved Gene / Pathway
Phase 2: March 2008
2FNP
33.1%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP04074
(
show subtarget assignments
)
1
cloned
No
BAS4469
49187464
50S ribosomal protein L20 [Bacillus anth...
118
Proposed to be essential proteins
Phase 4: April 2009
1VS6
55.1%
Bacillus anthracis
IDP02127
(
show subtarget assignments
)
1
cloned
No
FTT1116c
56708194
yajC
preprotein translocase family protein [F...
118
Conserved; Drug target functions
Phase 3: June 2008
2RDD
17.8%
Francisella tularensis
Protein fate
Protein and peptide secretion and trafficking
IDP91322
(
show subtarget assignments
)
8
cloned
No
VV2_0302
27366746
hypothetical protein VV2_0302 [Vibrio vu...
118
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP00889
(
show subtarget assignments
)
1
cloned
No
STM2495
16765815
yfgD
putative arsenate reductase
119
Conserved Gene / Pathway
Phase 2: March 2008
3RDW
61.3%
Salmonella enterica
Cellular processes
Detoxification
IDP04079
(
show subtarget assignments
)
1
purified
No
BAS0100
49183134
50S ribosomal protein L7/L12 [Bacillus a...
119
Proposed to be essential proteins
Phase 4: April 2009
1DD3
63.3%
Bacillus anthracis
IDP90398
(
show subtarget assignments
)
8
soluble
No
CT_577
3329019
hypothetical protein [Chlamydia trachoma...
119
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90567
(
show subtarget assignments
)
8
in_pdb
3R2E
No
YPO0648
16120973
folB
bifunctional dihydroneopterin aldolase/d...
119
Predicted Essential
Community Requests
3R2E
100%
Yersinia pestis
IDP02322
(
show subtarget assignments
)
1
soluble
No
lmo0691
16802733
cheY
chemotaxis response regulator CheY [List...
119
Known virulence-Regulation; PMID:15155625
Phase 3: June 2008
1TMY
63.9%
Listeria monocytogenes
Regulatory functions
Other
IDP05034
(
show subtarget assignments
)
1
soluble
No
BA_1274
30255223
conserved hypothetical protein [Bacillus...
119
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP90731
(
show subtarget assignments
)
8
soluble
No
YPO4101
16124209
rnpA
ribonuclease P [Yersinia pestis CO92]
119
Predicted Essential
Community Requests
2LJP
89.1%
Yersinia pestis
IDP00456
(
show subtarget assignments
)
1
in_pdb
3GSD
No
YPO0346
16120681
divalent-cation tolerance protein CutA
119
Conserved Gene / Pathway
Phase 2: March 2008
3GSD
100%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP05113
(
show subtarget assignments
)
1
in_pdb
4EGU
No
CD2447
126700064
histidine triad nucleotide-binding prote...
119
virulence/pathogenesis /
Targets associated with virulence and/or pathogenesis
Phase 5: 2010
4EGU
100%
Clostridium difficile
Unknown function: General
IDP91492
(
show subtarget assignments
)
8
purified
No
VP1693
28898467
putative type III secretion protein [Vib...
119
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2P58
40.3%
Vibrio parahaemolyticus
IDP01182
(
show subtarget assignments
)
1
in_pdb
3HYK
Yes
BA_0250
61211622
Holo-[acyl-carrier-protein] synthase (Ho...
119
Drug Target Function
Phase 2: March 2008
3HYK
100%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP90980
(
show subtarget assignments
)
8
cloned
No
y0801
22124714
iron-sulfur cluster insertion protein Er...
119
other biological interest /
protein possibly involved in iron-sulfur cluster synthesis
Community Requests
2APN
75.6%
Yersinia pestis
IDP90138
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_181
68449252
ankyrin-like protein [Monkeypox virus]
119
similar to VACV-COP-B6R, MPXV-ZAI96-B7R
Community Requests
Monkeypox virus
IDP01899
(
show subtarget assignments
)
1
expressed
No
STM2836
16766142
gutM
DNA-binding transcriptional activator Gu...
119
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Energy metabolism
Other
IDP05448
(
show subtarget assignments
)
1
soluble
No
lmo2594
16804632
-
hypothetical protein lmo2594 [Listeria m...
119
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP00816
(
show subtarget assignments
)
1
in_pdb
4DXE
3F09
Yes
SACOL2061
57284929
acpS
holo-(acyl-carrier-protein) synthase
119
Drug Target Function
Phase 2: March 2008
3F09
100%
Staphylococcus aureus
Fatty acid and phospholipid metabolism
Biosynthesis
IDP02260
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA0072
47777774
folB
dihydroneopterin aldolase [Bacillus anth...
120
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1DHN
43.3%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers
Folic acid
IDP91327
(
show subtarget assignments
)
8
soluble
No
VV2_0287
27366734
hypothetical protein VV2_0287 [Vibrio vu...
120
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04003
(
show subtarget assignments
)
1
cloned
No
BAS0126
49183160
50S ribosomal protein L18 [Bacillus anth...
120
Proposed to be essential proteins
Phase 4: April 2009
1OVY
75.8%
Bacillus anthracis
IDP05008
(
show subtarget assignments
)
1
cloned
No
CD1777
126699386
putative arsenate reductase [Clostridium...
120
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3FZ4
41.7%
Clostridium difficile
Cellular processes: Detoxification
IDP00852
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM3689
16766974
yibL
hypothetical protein STM3689
120
Conserved Gene / Pathway
Phase 2: March 2008
2LF0
90%
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP05437
(
show subtarget assignments
)
1
expressed
No
BA_2898
30257493
putative lipoprotein [Bacillus anthracis...
120
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP04306
(
show subtarget assignments
)
8
selected
No
CAC05809
12329078
ipgE
IpgE, cytoplasmic chaperone for IpgD [Sh...
120
Shigella effector protein
Community Requests
1K3S
27.5%
Shigella flexneri
IDP02123
(
show subtarget assignments
)
1
purified
No
YPO1255
16121542
hypothetical protein YPO1255 [Yersinia p...
120
Involved in virulence; Drug target functions
Phase 3: June 2008
Yersinia pestis
Hypothetical proteins
Conserved
IDP01905
(
show subtarget assignments
)
1
cloned
No
STM1113
16764471
scsA
suppression of copper sensitivity protei...
120
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unclassified
Role category not yet assigned
IDP04591
(
show subtarget assignments
)
1
cloned
No
BAS0138
49183172
50S ribosomal protein L17 [Bacillus anth...
120
Proposed to be essential proteins
Phase 4: April 2009
1NKW
50.8%
Bacillus anthracis
IDP02222
(
show subtarget assignments
)
1
crystallized
No
lmo0484
16802527
heme-degrading monooxygenase IsdG [Liste...
121
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
1TZ0
28.9%
Listeria monocytogenes
Hypothetical proteins
Conserved
IDP04023
(
show subtarget assignments
)
1
cloned
No
YPO0511a
115346321
hypothetical protein [Yersinia pestis CO...
121
virulence factor;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP04589
(
show subtarget assignments
)
1
expressed
No
BAS0135
49183169
30S ribosomal protein S13 [Bacillus anth...
121
Proposed to be essential proteins
Phase 4: April 2009
1FJG
63.9%
Bacillus anthracis
IDP02137
(
show subtarget assignments
)
1
soluble
No
Cj0547
15791908
flaG
flagellar protein FlaG [Campylobacter je...
121
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Biosynthesis of cofactors, prosthetic groups, and carriers
Heme, porphyrin, and cobalamin
IDP02193
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0868c
56707972
arsenical restistance operon repressor [...
121
Drug Target
Phase 3: June 2008
3JTH
22.3%
Francisella tularensis
Unclassified
Role category not yet assigned
IDP90943
(
show subtarget assignments
)
8
purified
No
BAS0032
49183067
DNA replication intiation control protei...
121
This is an essential protein that connects DNA replication to cell growth by bin...
Community Requests
Bacillus anthracis
IDP90310
(
show subtarget assignments
)
8
expressed
No
CT_716
3329172
hypothetical protein [Chlamydia trachoma...
121
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91331
(
show subtarget assignments
)
8
purified
No
VV2_0244
27366693
hypothetical protein VV2_0244 [Vibrio vu...
121
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2K54
28.9%
Vibrio vulnificus
IDP91353
(
show subtarget assignments
)
8
expressed
No
VV1_3072
27366341
Mu-like prophage protein gp16 [Vibrio vu...
122
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP00839
(
show subtarget assignments
)
1
purified
No
SACOL1328
57284485
glnR
glutamine synthetase repressor
122
Conserved Gene / Pathway
Phase 2: March 2008
3HH0
24.6%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP05484
(
show subtarget assignments
)
1
soluble
No
BA_3055
30257641
hypothetical protein BA_3055 [Bacillus a...
122
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04070
(
show subtarget assignments
)
1
cloned
No
FTT0073
56707252
sdhD
succinate dehydrogenase hydrophobic memb...
122
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1NEK
26.2%
Francisella tularensis
IDP04107
(
show subtarget assignments
)
1
purified
No
BAS0120
49183154
50S ribosomal protein L14 [Bacillus anth...
122
Proposed to be essential proteins
Phase 4: April 2009
1C04
86.9%
Bacillus anthracis
IDP04025
(
show subtarget assignments
)
1
expressed
No
YPCD1.36c
16082724
yscX
hypothetical protein YPCD1.36c [Yersinia...
122
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP05343
(
show subtarget assignments
)
1
soluble
No
Z1544
12514412
putative acyl-carrier protein synthase [...
122
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1FTE
36.1%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP91621
(
show subtarget assignments
)
8
soluble
No
BAB35649
13361692
ECs2226
hypothetical protein [Escherichia coli O...
123
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
35%
Escherichia coli
IDP91509
(
show subtarget assignments
)
8
soluble
No
VP1665
28898439
putative type III secretion protein [Vib...
123
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1XKP
35.8%
Vibrio parahaemolyticus
IDP00104
(
show subtarget assignments
)
1
purified
No
NT01SF3305
30042319
srlB
PTS system, glucitol/sorbitol-specific e...
123
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2F9H
25.2%
Shigella flexneri
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP05607
(
show subtarget assignments
)
1
soluble
No
BA_4862
30259361
putative lipoprotein [Bacillus anthracis...
123
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2JQO
23.6%
Bacillus anthracis
Cell envelope: Other
IDP02115
(
show subtarget assignments
)
1
purified
No
FTT0900
56708001
hypothetical protein FTT0900 [Francisell...
123
Drug Target
Community Requests
2GM2
22.8%
Francisella tularensis
Cell envelope
Other
IDP05503
(
show subtarget assignments
)
1
soluble
No
BA_4863
30259362
putative lipoprotein [Bacillus anthracis...
124
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP00142
(
show subtarget assignments
)
1
cloned
No
VC1456
15641467
ctxB
cholera enterotoxin, B subunit
124
Virulence
Phase 1: October 2007
1EEI
81.5%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP90316
(
show subtarget assignments
)
8
cloned
No
CT_743
3329202
hctA
Histone-Like Developmental Protein [Chla...
125
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91199
(
show subtarget assignments
)
1
cloned
No
BSU40540
16081106
yybR
putative transcriptional regulator [Baci...
125
other biological interest /
YybR belongs to the MarR/DUF24 family of transcriptional regulators that are hig...
Community Requests
4A5M
100%
Bacillus subtilis
IDP02202
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0774
56707886
hypothetical protein FTT0774 [Francisell...
125
Drug Target
Phase 3: June 2008
3USH
52.8%
Francisella tularensis
Unknown function
General
IDP04564
(
show subtarget assignments
)
1
cloned
No
CPF_1610
110800230
putative lipoprotein [Clostridium perfri...
125
drug target; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cell envelope
Other
IDP90182
(
show subtarget assignments
)
8
soluble
No
AAM13479.1
20153018
CPXV032
CPXV032 protein
125
kelch-like protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP91510
(
show subtarget assignments
)
8
cloned
No
VP1664
28898438
putative type III secretion protein [Vib...
126
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP90634
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO3403
16123552
panD
aspartate alpha-decarboxylase [Yersinia ...
126
Predicted Essential
Community Requests
1PPY
78.6%
Yersinia pestis
IDP05767
(
show subtarget assignments
)
1
soluble
No
S2798
30042221
acpS
CoA:apo-[acyl-carrier-protein] pantethei...
126
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3H88
55.6%
Shigella flexneri
Fatty acid and phospholipid metabolism: Biosynthesis
IDP01461
(
show subtarget assignments
)
1
in_pdb
3H88
No
VC2457
15642453
acpS
4'-phosphopantetheinyl transferase
126
Drug Target Function
Phase 2: March 2008
3H88
100%
Vibrio cholerae
Fatty acid and phospholipid metabolism
Biosynthesis
IDP90177
(
show subtarget assignments
)
8
expressed
No
AAM13471.1
20153010
CPXV024 CDS
CPXV024 protein
126
Orthopoxvirus interleukin 18 binding protein; plays a key role in the activation...
Community Requests
3F62
80.2%
Cowpox virus
host defense modulator
0
IDP00113
(
show subtarget assignments
)
0
work_stopped
No
NT01SAA0015
16119212
blaI
PENICILLINASE REPRESSOR
126
Virulence
Phase 1: October 2007
1SD4
100%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP90214
(
show subtarget assignments
)
8
expressed
No
MYXV_gp017
9633649
m013L
m013L, M013L
126
interferon inducible protein
Community Requests
Myxoma virus
unknown
0
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