Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91961 (show subtarget assignments)	8	in_pdb 4EQ9	No	SpneCM_010100005438	298255041		ABC transporter substrate-binding protei...	276	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	4EQ9	88%	Streptococcus pneumoniae

IDP05631 (show subtarget assignments)	1	crystallized	No	CD1979	126699588		ABC transporter, substrate-binding prote...	337	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IX1	26.4%	Clostridium difficile	Transport and binding proteins: Unknown substrate

IDP05119 (show subtarget assignments)	1	soluble	No	CD2989	126700610		ABC transporter, substrate-binding prote...	319	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2X7P	23.5%	Clostridium difficile	Transport and binding proteins: Unknown substrate

IDP04548 (show subtarget assignments)	1	cloned	No	CPF_2413	110801184		ABC transporter, substrate-binding prote...	298	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2O1E	36.4%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04248 (show subtarget assignments)	1	in_pdb 4EDP	No	CPF_1477	110800354		ABC transporter, substrate-binding prote...	348	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EDP	100%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP91966 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100001092	298254195		ABC transporter substrate-binding protei...	271	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1GGG	28.4%	Streptococcus pneumoniae

IDP91975 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100009843	298255879		ABC transporter substrate-binding protei...	278	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3HV1	60.1%	Streptococcus pneumoniae

IDP91955 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100006939	298255319		ABC transporter substrate-binding protei...	341	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3EIW	22.3%	Streptococcus pneumoniae

IDP05024 (show subtarget assignments)	1	soluble	No	BAS4675	49187666	-	ABC transporter, substrate-binding prote...	325	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IX1	20.6%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP91987 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100008765	298255669		ABC transporter substrate-binding protei...	335	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3IX1	26.3%	Streptococcus pneumoniae

IDP91964 (show subtarget assignments)	8	purified	No	SpneCM_010100007935	298255513		ABC transporter, substrate-binding prote...	538	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3OMB	28.4%	Streptococcus pneumoniae

IDP91956 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100005733	298255095		ABC transporter, substrate-binding prote...	353	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1Y4T	19.8%	Streptococcus pneumoniae

IDP91990 (show subtarget assignments)	8	selected	No	SpneCM_010100004332	298254829		ABC transporter substrate-binding protei...	80	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1XT8	41.2%	Streptococcus pneumoniae

IDP91402 (show subtarget assignments)	8	purified	No	VV1_1001	27364435		ABC-type amino acid transport, signal tr...	250	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1GGG	31.2%	Vibrio vulnificus

IDP91400 (show subtarget assignments)	8	cloned	No	VV1_1002	27364436		ABC-type amino acid transport system, pe...	223	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3DHW	23.3%	Vibrio vulnificus

IDP91944 (show subtarget assignments)	8	selected	No	SpneCM_010100000842	298254147		ABC-type antimicrobial peptide transport...	419	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3FTJ	10.5%	Streptococcus pneumoniae

IDP91315 (show subtarget assignments)	8	expressed	No	VV2_0482	27366916		ABC-type bacteriocin/lantibiotic exporte...	535	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2HYD	32.7%	Vibrio vulnificus

IDP91334 (show subtarget assignments)	8	purified	No	VV2_0179	27366635		ABC-type multidrug transport system, ATP...	586	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2YL4	36.2%	Vibrio vulnificus

IDP91442 (show subtarget assignments)	8	in_crystallization_trials	No	VV1_0466	27363933		ABC-type phosphate transport system, per...	317	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91371 (show subtarget assignments)	8	purified	No	VV1_2224	27365549		ABC-type uncharacterized transport syste...	321	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3LKV	79.8%	Vibrio vulnificus

IDP00165 (show subtarget assignments)	1	cloned	No	VC0844	15640861	acfA	accessory colonization factor AcfA	215	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00164 (show subtarget assignments)	1	soluble	No	VC0841	15640858	acfC	accessory colonization factor AcfC	256	Virulence	Phase 1: October 2007	3FIR	50%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP91057 (show subtarget assignments)	8	cloned	No	USA300HOU_2035	161510252	agrA	accessory gene regulator protein A [Stap...	238	virulence/pathogenesis / The target is a drug target for anti-virulence therapy in infections of Methicil...	Community Requests	3BS1	42.9%	Staphylococcus aureus

IDP91537 (show subtarget assignments)	8	in_crystallization_trials	No	SAR1789	49483952	ackA	acetate kinase [Staphylococcus aureus su...	400	potential drug target / Protein is a proposed to be a S. aureus (MRSA252) drug target and having crystal...	Community Requests	2IIR	56%	Staphylococcus aureus

IDP91373 (show subtarget assignments)	8	in_crystallization_trials	No	VV1_2221	27365547		acetate kinase [Vibrio vulnificus CMCP6]...	398	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2IIR	47.4%	Vibrio vulnificus

IDP02724 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1330	47526596	fabG	acetoacetyl-CoA reductase [Bacillus anth...	247	Essential; Drug target functions	Phase 3: June 2008	2UVD	46.6%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02113 (show subtarget assignments)	1	in_crystallization_trials	No	STM3901	16767177	ilvG	acetolactate synthase 2 catalytic subuni...	548	Conserved; Drug target functions	Phase 3: June 2008	1YBH	46.7%	Salmonella enterica	Amino acid biosynthesis	Pyruvate family

IDP02401 (show subtarget assignments)	1	cloned	No	Cj0574	15791934	ilvI	acetolactate synthase 3 catalytic subuni...	566	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1JSC	40.7%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01883 (show subtarget assignments)	1	expressed	No	STM0116	16763506	ilvI	acetolactate synthase 3 catalytic subuni...	553	Conserved; Drug target functions	Phase 3: June 2008	1JSC	43.7%	Salmonella enterica	Amino acid biosynthesis	Pyruvate family

IDP90778 (show subtarget assignments)	8	soluble	No	Cj0575	15791935	ilvH	acetolactate synthase 3 regulatory subun...	154	Predicted Essential	Community Requests	2F1F	40.3%	Campylobacter jejuni

IDP01792 (show subtarget assignments)	1	expressed	No	GBAA0866	47777865	alsS	acetolactate synthase [Bacillus anthraci...	562	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1OZF	50.7%	Bacillus anthracis	Energy metabolism	Fermentation

IDP04333 (show subtarget assignments)	1	cloned	No	VC2483	9657062		acetolactate synthase III, large subunit...	573	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1JSC	42.8%	Vibrio cholerae	Amino acid biosynthesis	Pyruvate family

IDP04355 (show subtarget assignments)	1	purified	No	YPO0539	115346347	ilvI	acetolactate synthase isozyme III large ...	575	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1JSC	43.1%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP04318 (show subtarget assignments)	1	soluble	No	YPO0540	115346348	ilvH	acetolactate synthase isozyme III small ...	164	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2F1F	87.2%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP92079 (show subtarget assignments)	8	selected	No	TGME49_101120	237844673		acetyil CoA acetyltransferase/thiolase, ...	413	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2F2S	45.9%	Toxoplasma gondii

IDP02432 (show subtarget assignments)	1	soluble	No	GBAA3687	47528971		acetyl-CoA acetyltransferase [Bacillus a...	363	Drug target motif; Conserved; Essential; Involved in sporulation; Drug target fu...	Phase 3: June 2008	4DD5	39.6%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Other

IDP01724 (show subtarget assignments)	1	expressed	No	GBAA5248	47530553		acetyl-CoA acetyltransferase [Bacillus a...	390	Conserved; Essential; Drug target functions	Phase 3: June 2008	2C7Y	47.9%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Other

IDP02729 (show subtarget assignments)	1	in_pdb 3SS6	Yes	GBAA4240	47529533		acetyl-CoA acetyltransferase [Bacillus a...	391	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3SS6	99.7%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Other

IDP05060 (show subtarget assignments)	1	in_pdb 4DD5	Yes	CD1059	126698643	thlA1	acetyl-CoA acetyltransferase [Clostridiu...	396	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	4DD5	100%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP04655 (show subtarget assignments)	1	soluble	No	FTT1531	56708565	fadA	acetyl-CoA acetyltransferase [Francisell...	395	drug target; conserved gene;	Phase 4: April 2009	1ULQ	45.7%	Francisella tularensis	Fatty acid and phospholipid metabolism	Other

IDP04638 (show subtarget assignments)	1	expressed	No	FTT0372c	56707523	accD	Acetyl-CoA carboxylase beta subunit [Fra...	302	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	60.3%	Francisella tularensis

IDP02748 (show subtarget assignments)	1	expressed	No	GBAA4408	47529702	accC	acetyl-CoA carboxylase biotin carboxylas...	450	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2VPQ	66.4%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02328 (show subtarget assignments)	1	expressed	No	GBAA2548	47527837		acetyl-CoA carboxylase biotin carboxylas...	445	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3N6R	51.9%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP90725 (show subtarget assignments)	8	soluble	No	VC0295	15640323		acetyl-CoA carboxylase biotin carboxylas...	447	Predicted Essential	Community Requests	1BNC	85.5%	Vibrio cholerae

IDP91274 (show subtarget assignments)	8	soluble	No	NT05BA4272	49181014		acetyl-CoA carboxylase, biotin carboxyl ...	164	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1A6X	23.2%	Bacillus anthracis	Fatty acid and phospholipid metabolism: Biosynthesis

IDP90751 (show subtarget assignments)	8	cloned	No	Cj1291c	15792614	accB	acetyl-CoA carboxylase biotin carboxyl c...	151	Predicted Essential	Community Requests	1A6X	27.2%	Campylobacter jejuni

IDP04621 (show subtarget assignments)	1	cloned	No	BAS4494	49187489		acetyl-CoA carboxylase carboxyltransfera...	324	Proposed to be essential proteins	Phase 4: April 2009	2F9I	60.2%	Bacillus anthracis

IDP04171 (show subtarget assignments)	1	cloned	No	VC2244	15642242		acetyl-CoA carboxylase carboxyltransfera...	319	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	74.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP90833 (show subtarget assignments)	8	expressed	No	YPO1060	16121360	accA	acetyl-CoA carboxylase carboxyltransfera...	319	Predicted Essential	Community Requests	2F9Y	89.7%	Yersinia pestis

IDP00116 (show subtarget assignments)	0	work_stopped	No	NT01ST0285	16763622	accA	acetylCoA carboxylase, carboxytransferas...	319	Essential	Phase 1: October 2007	2F9Y	96.9%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP90589 (show subtarget assignments)	8	soluble	No	VC0296	15640324		acetyl-CoA carboxylase [Vibrio cholerae ...	196	Predicted Essential	Community Requests	1A6X	37.2%	Vibrio cholerae

IDP02156 (show subtarget assignments)	1	soluble	No	YPO0253	16120590	acs	acetyl-CoA synthetase [Yersinia pestis C...	652	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	2P2F	83.9%	Yersinia pestis	Central intermediary metabolism	Other

IDP91243 (show subtarget assignments)	8	expressed	No	HP0690	2313814		acetyl coenzyme A acetyltransferase (thi...	391	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	4DD5	54.2%	Helicobacter pylori	Fatty acid and phospholipid metabolism: Biosynthesis

IDP04123 (show subtarget assignments)	1	expressed	No	YPO2768	115348451	accD	acetyl-coenzyme A carboxylase carboxyl t...	304	conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	84.5%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00896 (show subtarget assignments)	1	in_pdb 3GA7	No	STM0490	16763870	aes	acetyl esterase	323	Conserved Gene / Pathway	Phase 2: March 2008	3GA7	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP00203 (show subtarget assignments)	1	in_pdb 3T7B	No	YPO3925	16124056	argB	acetylglutamate kinase	257	Virulence	Phase 1: October 2007	3T7B	100%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01077 (show subtarget assignments)	0	work_stopped	No	STM4122	161353577	argB	acetylglutamate kinase	257	Conserved Gene / Pathway	Phase 2: March 2008	1GS5	94.2%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP02670 (show subtarget assignments)	1	cloned	No	GBAA4353	47529649	argB	acetylglutamate kinase [Bacillus anthrac...	255	Conserved; Drug target functions	Phase 3: June 2008	2BTY	43.1%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP90691 (show subtarget assignments)	8	soluble	No	VC2643	15642638		acetylglutamate kinase [Vibrio cholerae ...	262	Predicted Essential	Community Requests	3T7B	59.5%	Vibrio cholerae

IDP02736 (show subtarget assignments)	1	cloned	No	GBAA4352	47778283	argD	acetylornithine aminotransferase [Bacill...	386	Conserved; Essential; Drug target functions	Phase 3: June 2008	2E54	44%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP90574 (show subtarget assignments)	8	in_pdb 3NX3	No	Cj0227	15791599	argD	acetylornithine aminotransferase [Campyl...	395	Predicted Essential	Community Requests	3NX3	100%	Campylobacter jejuni

IDP01076 (show subtarget assignments)	8	expressed	No	STM4120	16767385	argE	acetylornithine deacetylase	383	Drug Target Function	Community Requests	3CT9	25.1%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP90248 (show subtarget assignments)	8	purified	No	BAS0467	49183495		acetylornithine deacetylase [Bacillus an...	426	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3PFO	27%	Bacillus anthracis

IDP90250 (show subtarget assignments)	8	expressed	No	Z5515	15804553	argE	acetylornithine deacetylase [Escherichia...	383	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3IC1	26.9%	Escherichia coli

IDP90251 (show subtarget assignments)	8	expressed	No	SF4034	56480493	argE	acetylornithine deacetylase [Shigella fl...	383	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2F7V	25.1%	Shigella flexneri

IDP90249 (show subtarget assignments)	8	soluble	No	VC2645	15642640		acetylornithine deacetylase [Vibrio chol...	378	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2F7V	26.8%	Vibrio cholerae

IDP90247 (show subtarget assignments)	8	purified	No	YPO3928	115349537	argE	acetylornithine deacetylase [Yersinia pe...	389	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3PFO	26%	Yersinia pestis

IDP91270 (show subtarget assignments)	8	soluble	No	NT05BA3459	49180224		acetyltransf2, N-acetyltransferase [Baci...	217	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LNB	47.9%	Bacillus anthracis	Unknown function: Enzymes of unknown specificity

IDP01725 (show subtarget assignments)	0	work_stopped	No	GBAA2534	47527824		acetyltransferase [Bacillus anthracis st...	168	CONSERVED	Phase 3: June 2008	3FBU	100%	Bacillus anthracis	N/A	N/A

IDP00054 (show subtarget assignments)	1	crystallized	No	BA_3600	30258128		acetyltransferase, CYSE/LACA/LPXA/NODL f...	185	Virulence	Phase 1: October 2007	1KHR	42.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00043 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2629	30257246		acetyltransferase, CYSE/LACA/LPXA/NODL f...	210	Virulence	Phase 1: October 2007	4E8L	63.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02595 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1384c	56708433		acetyltransferase [Francisella tularensi...	163	Drug Target	Phase 3: June 2008			Francisella tularensis	Central intermediary metabolismUnknown function	OtherEnzymes of unknown specificity

IDP00739 (show subtarget assignments)	1	diffraction	No	SACOL1063	57284433		acetyltransferase, GNAT family	144	Drug Target Function	Phase 2: March 2008	1Q2Y	40.3%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP00844 (show subtarget assignments)	1	diffraction	No	SACOL0519	57285544		acetyltransferase, GNAT family	174	Drug Target Function	Phase 2: March 2008			Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP91269 (show subtarget assignments)	8	soluble	No	NT05BA2958	49179731		acetyltransferase, GNAT family [Bacillus...	180	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1NSL	30.6%	Bacillus anthracis	Protein synthesis: Ribosomal proteins: synthesis and modification

IDP00661 (show subtarget assignments)	1	purified	No	SACOL0827	57284289		acetyltransferase, putative	161	Drug Target Function	Phase 2: March 2008	1OCX	30.4%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP91546 (show subtarget assignments)	8	in_pdb 4E8L	No	AAA26683	398085	vat	acetyltransferase [Staphylococcus aureus...	219	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	4E8L	100%	Staphylococcus aureus

IDP02744 (show subtarget assignments)	1	cloned	No	FTT0087	56707265	acnA	aconitate hydratase [Francisella tularen...	937	Drug Target	Phase 3: June 2008	3SN2	50.5%	Francisella tularensis	Energy metabolism	TCA cycle

IDP01963 (show subtarget assignments)	1	purified	No	STM1712	16765056	acnA	aconitate hydratase [Salmonella typhimur...	891	Conserved; Drug target functions	Phase 3: June 2008	3SN2	52.3%	Salmonella enterica	Energy metabolism	TCA cycle

IDP02220 (show subtarget assignments)	1	cloned	No	YPO2221	16122450	acnA	aconitate hydratase [Yersinia pestis CO9...	890	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3SN2	52.2%	Yersinia pestis	Energy metabolism	TCA cycle

IDP01843 (show subtarget assignments)	1	cloned	No	lmo0204	16802250	actA	actin-assembly inducing protein precurso...	639	Known virulence-Nucleation-promoting factor; Predicted virulence-Pathogenicity i...	Phase 3: June 2008			Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP01025 (show subtarget assignments)	1	cloned	No	STM1196	16764551	acpP	acyl carrier protein	78	Conserved Gene / Pathway	Phase 2: March 2008	1L0H	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02407 (show subtarget assignments)	1	cloned	No	GBAA3988	47529279	acpP	acyl carrier protein [Bacillus anthracis...	77	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2X2B	81.8%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP91643 (show subtarget assignments)	8	cloned	No	NP_215860	15608484		acyl carrier protein [Mycobacterium tube...	106	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	4DXE	19.8%	Mycobacterium tuberculosis

IDP04320 (show subtarget assignments)	1	in_pdb 4ESE	No	YPO2323	115348026	acpD	acyl carrier protein phosphodiesterase [...	201	conserved gene; putative drug target function;	Phase 4: April 2009	1T5B	81.1%	Yersinia pestis	Fatty acid and phospholipid metabolism	Other

IDP01440 (show subtarget assignments)	1	in_pdb 3HJV	No	VC2022	15642024		acyl carrier protein S-malonyltransferas...	312	Drug Target Function	Phase 2: March 2008	3HJV	100%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00426 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1598	16121866	fabD	acyl carrier protein S-malonyltransferas...	309	Conserved Gene / Pathway	Phase 2: March 2008	3H0P	79.3%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00956 (show subtarget assignments)	1	in_pdb 3H0P	No	STM1194	16764549	fabD	acyl carrier protein S-malonyltransferas...	309	potential drug target / Essential Gene	Phase 2: March 2008	3H0P	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00352 (show subtarget assignments)	1	purified	No	lmo1808	16803848	fabD	acyl-carrier-protein S-malonyltransferas...	313	Drug Target Function	Phase 2: March 2008	3IM9	46.6%	Listeria monocytogenes	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02763 (show subtarget assignments)	1	cloned	No	GBAA2547	47527836		acyl-CoA dehydrogenase [Bacillus anthrac...	381	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2VIG	50.4%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP04432 (show subtarget assignments)	1	in_pdb 3OWA	No	GBAA5246	47530551		acyl-CoA dehydrogenase [Bacillus anthrac...	594	conserved gene; putative drug target function;	Phase 4: April 2009	3OWA	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP91645 (show subtarget assignments)	8	soluble	No	NP_215862	15608486		acyl-CoA dehydrogenase [Mycobacterium tu...	386	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	1WS9	27.2%	Mycobacterium tuberculosis

IDP90795 (show subtarget assignments)	8	cloned	No	YPO3244	16123403	fadE	acyl-CoA dehydrogenase [Yersinia pestis ...	815	Predicted Essential	Community Requests	2UXW	18.8%	Yersinia pestis

IDP91636 (show subtarget assignments)	8	cloned	No	NP_217464	15610085		acyl-CoA synthetase [Mycobacterium tuber...	705	virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...	Community Requests	2V7B	23%	Mycobacterium tuberculosis

IDP91647 (show subtarget assignments)	8	cloned	No	NP_217446	57117038		acyl-CoA synthetase [Mycobacterium tuber...	583	virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...	Community Requests	3E53	45.1%	Mycobacterium tuberculosis

IDP91648 (show subtarget assignments)	8	cloned	No	NP_217466	161352463		acyl-CoA synthetase [Mycobacterium tuber...	582	virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...	Community Requests	3E53	44.8%	Mycobacterium tuberculosis

IDP90631 (show subtarget assignments)	8	expressed	No	YPO2526	16122745		acyl-CoA thioester hydrolase YfbB [Yersi...	272	Predicted Essential	Community Requests	1R3D	42.3%	Yersinia pestis

IDP02057 (show subtarget assignments)	1	soluble	No	Cj1311	15792634	neuA2	acylneuraminate cytidylyltransferase [Ca...	232	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...	Phase 3: June 2008	1QWJ	26.3%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02546 (show subtarget assignments)	1	expressed	No	Cj1143	15792468	neuA1	acylneuraminate cytidylyltransferase [Ca...	536	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	1EYR	16.2%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01775 (show subtarget assignments)	1	cloned	No	Cj1331	15792654	ptmB	acylneuraminate cytidylyltransferase (fl...	235	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...	Phase 3: June 2008	1EYR	28.9%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP91961
(show subtarget assignments)

8

in_pdb
4EQ9

No

SpneCM_010100005438

298255041

ABC transporter substrate-binding protei...

276

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

4EQ9

88%

Streptococcus pneumoniae

IDP05631
(show subtarget assignments)

1

crystallized

No

CD1979

126699588

ABC transporter, substrate-binding prote...

337

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IX1

26.4%

Clostridium difficile

Transport and binding proteins: Unknown substrate

IDP05119
(show subtarget assignments)

1

soluble

No

CD2989

126700610

ABC transporter, substrate-binding prote...

319

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2X7P

23.5%

Clostridium difficile

Transport and binding proteins: Unknown substrate

IDP04548
(show subtarget assignments)

1

cloned

No

CPF_2413

110801184

ABC transporter, substrate-binding prote...

298

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2O1E

36.4%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04248
(show subtarget assignments)

1

in_pdb
4EDP

No

CPF_1477

110800354

ABC transporter, substrate-binding prote...

348

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EDP

100%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP91966
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100001092

298254195

ABC transporter substrate-binding protei...

271

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1GGG

28.4%

Streptococcus pneumoniae

IDP91975
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100009843

298255879

ABC transporter substrate-binding protei...

278

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3HV1

60.1%

Streptococcus pneumoniae

IDP91955
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100006939

298255319

ABC transporter substrate-binding protei...

341

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3EIW

22.3%

Streptococcus pneumoniae

IDP05024
(show subtarget assignments)

1

soluble

No

BAS4675

49187666

-

ABC transporter, substrate-binding prote...

325

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IX1

20.6%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP91987
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100008765

298255669

ABC transporter substrate-binding protei...

335

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3IX1

26.3%

Streptococcus pneumoniae

IDP91964
(show subtarget assignments)

8

purified

No

SpneCM_010100007935

298255513

ABC transporter, substrate-binding prote...

538

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3OMB

28.4%

Streptococcus pneumoniae

IDP91956
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100005733

298255095

ABC transporter, substrate-binding prote...

353

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1Y4T

19.8%

Streptococcus pneumoniae

IDP91990
(show subtarget assignments)

8

selected

No

SpneCM_010100004332

298254829

ABC transporter substrate-binding protei...

80

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1XT8

41.2%

Streptococcus pneumoniae

IDP91402
(show subtarget assignments)

8

purified

No

VV1_1001

27364435

ABC-type amino acid transport, signal tr...

250

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1GGG

31.2%

Vibrio vulnificus

IDP91400
(show subtarget assignments)

8

cloned

No

VV1_1002

27364436

ABC-type amino acid transport system, pe...

223

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3DHW

23.3%

Vibrio vulnificus

IDP91944
(show subtarget assignments)

8

selected

No

SpneCM_010100000842

298254147

ABC-type antimicrobial peptide transport...

419

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3FTJ

10.5%

Streptococcus pneumoniae

IDP91315
(show subtarget assignments)

8

expressed

No

VV2_0482

27366916

ABC-type bacteriocin/lantibiotic exporte...

535

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2HYD

32.7%

Vibrio vulnificus

IDP91334
(show subtarget assignments)

8

purified

No

VV2_0179

27366635

ABC-type multidrug transport system, ATP...

586

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2YL4

36.2%

Vibrio vulnificus

IDP91442
(show subtarget assignments)

8

in_crystallization_trials

No

VV1_0466

27363933

ABC-type phosphate transport system, per...

317

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91371
(show subtarget assignments)

8

purified

No

VV1_2224

27365549

ABC-type uncharacterized transport syste...

321

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3LKV

79.8%

Vibrio vulnificus

IDP00165
(show subtarget assignments)

1

cloned

No

VC0844

15640861

acfA

accessory colonization factor AcfA

215

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00164
(show subtarget assignments)

1

soluble

No

VC0841

15640858

acfC

accessory colonization factor AcfC

256

Virulence

Phase 1: October 2007

3FIR

50%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP91057
(show subtarget assignments)

8

cloned

No

USA300HOU_2035

161510252

agrA

accessory gene regulator protein A [Stap...

238

virulence/pathogenesis / The target is a drug target for anti-virulence therapy in infections of Methicil...

Community Requests

3BS1

42.9%

Staphylococcus aureus

IDP91537
(show subtarget assignments)

8

in_crystallization_trials

No

SAR1789

49483952

ackA

acetate kinase [Staphylococcus aureus su...

400

potential drug target / Protein is a proposed to be a S. aureus (MRSA252) drug target and having crystal...

Community Requests

2IIR

56%

Staphylococcus aureus

IDP91373
(show subtarget assignments)

8

in_crystallization_trials

No

VV1_2221

27365547

acetate kinase [Vibrio vulnificus CMCP6]...

398

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2IIR

47.4%

Vibrio vulnificus

IDP02724
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1330

47526596

fabG

acetoacetyl-CoA reductase [Bacillus anth...

247

Essential; Drug target functions

Phase 3: June 2008

2UVD

46.6%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02113
(show subtarget assignments)

1

in_crystallization_trials

No

STM3901

16767177

ilvG

acetolactate synthase 2 catalytic subuni...

548

Conserved; Drug target functions

Phase 3: June 2008

1YBH

46.7%

Salmonella enterica

Amino acid biosynthesis

Pyruvate family

IDP02401
(show subtarget assignments)

1

cloned

No

Cj0574

15791934

ilvI

acetolactate synthase 3 catalytic subuni...

566

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1JSC

40.7%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01883
(show subtarget assignments)

1

expressed

No

STM0116

16763506

ilvI

acetolactate synthase 3 catalytic subuni...

553

Conserved; Drug target functions

Phase 3: June 2008

1JSC

43.7%

Salmonella enterica

Amino acid biosynthesis

Pyruvate family

IDP90778
(show subtarget assignments)

8

soluble

No

Cj0575

15791935

ilvH

acetolactate synthase 3 regulatory subun...

154

Predicted Essential

Community Requests

2F1F

40.3%

Campylobacter jejuni

IDP01792
(show subtarget assignments)

1

expressed

No

GBAA0866

47777865

alsS

acetolactate synthase [Bacillus anthraci...

562

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1OZF

50.7%

Bacillus anthracis

Energy metabolism

Fermentation

IDP04333
(show subtarget assignments)

1

cloned

No

VC2483

9657062

acetolactate synthase III, large subunit...

573

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1JSC

42.8%

Vibrio cholerae

Amino acid biosynthesis

Pyruvate family

IDP04355
(show subtarget assignments)

1

purified

No

YPO0539

115346347

ilvI

acetolactate synthase isozyme III large ...

575

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1JSC

43.1%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP04318
(show subtarget assignments)

1

soluble

No

YPO0540

115346348

ilvH

acetolactate synthase isozyme III small ...

164

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2F1F

87.2%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP92079
(show subtarget assignments)

8

selected

No

TGME49_101120

237844673

acetyil CoA acetyltransferase/thiolase, ...

413

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2F2S

45.9%

Toxoplasma gondii

IDP02432
(show subtarget assignments)

1

soluble

No

GBAA3687

47528971

acetyl-CoA acetyltransferase [Bacillus a...

363

Drug target motif; Conserved; Essential; Involved in sporulation; Drug target fu...

Phase 3: June 2008

4DD5

39.6%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Other

IDP01724
(show subtarget assignments)

1

expressed

No

GBAA5248

47530553

acetyl-CoA acetyltransferase [Bacillus a...

390

Conserved; Essential; Drug target functions

Phase 3: June 2008

2C7Y

47.9%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Other

IDP02729
(show subtarget assignments)

1

in_pdb
3SS6

Yes

GBAA4240

47529533

acetyl-CoA acetyltransferase [Bacillus a...

391

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3SS6

99.7%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Other

IDP05060
(show subtarget assignments)

1

in_pdb
4DD5

Yes

CD1059

126698643

thlA1

acetyl-CoA acetyltransferase [Clostridiu...

396

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

4DD5

100%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP04655
(show subtarget assignments)

1

soluble

No

FTT1531

56708565

fadA

acetyl-CoA acetyltransferase [Francisell...

395

drug target; conserved gene;

Phase 4: April 2009

1ULQ

45.7%

Francisella tularensis

Fatty acid and phospholipid metabolism

Other

IDP04638
(show subtarget assignments)

1

expressed

No

FTT0372c

56707523

accD

Acetyl-CoA carboxylase beta subunit [Fra...

302

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

60.3%

Francisella tularensis

IDP02748
(show subtarget assignments)

1

expressed

No

GBAA4408

47529702

accC

acetyl-CoA carboxylase biotin carboxylas...

450

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2VPQ

66.4%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02328
(show subtarget assignments)

1

expressed

No

GBAA2548

47527837

acetyl-CoA carboxylase biotin carboxylas...

445

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3N6R

51.9%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP90725
(show subtarget assignments)

8

soluble

No

VC0295

15640323

acetyl-CoA carboxylase biotin carboxylas...

447

Predicted Essential

Community Requests

1BNC

85.5%

Vibrio cholerae

IDP91274
(show subtarget assignments)

8

soluble

No

NT05BA4272

49181014

acetyl-CoA carboxylase, biotin carboxyl ...

164

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1A6X

23.2%

Bacillus anthracis

Fatty acid and phospholipid metabolism: Biosynthesis

IDP90751
(show subtarget assignments)

8

cloned

No

Cj1291c

15792614

accB

acetyl-CoA carboxylase biotin carboxyl c...

151

Predicted Essential

Community Requests

1A6X

27.2%

Campylobacter jejuni

IDP04621
(show subtarget assignments)

1

cloned

No

BAS4494

49187489

acetyl-CoA carboxylase carboxyltransfera...

324

Proposed to be essential proteins

Phase 4: April 2009

2F9I

60.2%

Bacillus anthracis

IDP04171
(show subtarget assignments)

1

cloned

No

VC2244

15642242

acetyl-CoA carboxylase carboxyltransfera...

319

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

74.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP90833
(show subtarget assignments)

8

expressed

No

YPO1060

16121360

accA

acetyl-CoA carboxylase carboxyltransfera...

319

Predicted Essential

Community Requests

2F9Y

89.7%

Yersinia pestis

IDP00116
(show subtarget assignments)

0

work_stopped

No

NT01ST0285

16763622

accA

acetylCoA carboxylase, carboxytransferas...

319

Essential

Phase 1: October 2007

2F9Y

96.9%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP90589
(show subtarget assignments)

8

soluble

No

VC0296

15640324

acetyl-CoA carboxylase [Vibrio cholerae ...

196

Predicted Essential

Community Requests

1A6X

37.2%

Vibrio cholerae

IDP02156
(show subtarget assignments)

1

soluble

No

YPO0253

16120590

acs

acetyl-CoA synthetase [Yersinia pestis C...

652

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

2P2F

83.9%

Yersinia pestis

Central intermediary metabolism

Other

IDP91243
(show subtarget assignments)

8

expressed

No

HP0690

2313814

acetyl coenzyme A acetyltransferase (thi...

391

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

4DD5

54.2%

Helicobacter pylori

Fatty acid and phospholipid metabolism: Biosynthesis

IDP04123
(show subtarget assignments)

1

expressed

No

YPO2768

115348451

accD

acetyl-coenzyme A carboxylase carboxyl t...

304

conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

84.5%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00896
(show subtarget assignments)

1

in_pdb
3GA7

No

STM0490

16763870

aes

acetyl esterase

323

Conserved Gene / Pathway

Phase 2: March 2008

3GA7

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP00203
(show subtarget assignments)

1

in_pdb
3T7B

No

YPO3925

16124056

argB

acetylglutamate kinase

257

Virulence

Phase 1: October 2007

3T7B

100%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01077
(show subtarget assignments)

0

work_stopped

No

STM4122

161353577

argB

acetylglutamate kinase

257

Conserved Gene / Pathway

Phase 2: March 2008

1GS5

94.2%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP02670
(show subtarget assignments)

1

cloned

No

GBAA4353

47529649

argB

acetylglutamate kinase [Bacillus anthrac...

255

Conserved; Drug target functions

Phase 3: June 2008

2BTY

43.1%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP90691
(show subtarget assignments)

8

soluble

No

VC2643

15642638

acetylglutamate kinase [Vibrio cholerae ...

262

Predicted Essential

Community Requests

3T7B

59.5%

Vibrio cholerae

IDP02736
(show subtarget assignments)

1

cloned

No

GBAA4352

47778283

argD

acetylornithine aminotransferase [Bacill...

386

Conserved; Essential; Drug target functions

Phase 3: June 2008

2E54

44%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP90574
(show subtarget assignments)

8

in_pdb
3NX3

No

Cj0227

15791599

argD

acetylornithine aminotransferase [Campyl...

395

Predicted Essential

Community Requests

3NX3

100%

Campylobacter jejuni

IDP01076
(show subtarget assignments)

8

expressed

No

STM4120

16767385

argE

acetylornithine deacetylase

383

Drug Target Function

Community Requests

3CT9

25.1%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP90248
(show subtarget assignments)

8

purified

No

BAS0467

49183495

acetylornithine deacetylase [Bacillus an...

426

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3PFO

27%

Bacillus anthracis

IDP90250
(show subtarget assignments)

8

expressed

No

Z5515

15804553

argE

acetylornithine deacetylase [Escherichia...

383

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3IC1

26.9%

Escherichia coli

IDP90251
(show subtarget assignments)

8

expressed

No

SF4034

56480493

argE

acetylornithine deacetylase [Shigella fl...

383

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2F7V

25.1%

Shigella flexneri

IDP90249
(show subtarget assignments)

8

soluble

No

VC2645

15642640

acetylornithine deacetylase [Vibrio chol...

378

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2F7V

26.8%

Vibrio cholerae

IDP90247
(show subtarget assignments)

8

purified

No

YPO3928

115349537

argE

acetylornithine deacetylase [Yersinia pe...

389

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3PFO

26%

Yersinia pestis

IDP91270
(show subtarget assignments)

8

soluble

No

NT05BA3459

49180224

acetyltransf2, N-acetyltransferase [Baci...

217

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LNB

47.9%

Bacillus anthracis

Unknown function: Enzymes of unknown specificity

IDP01725
(show subtarget assignments)

0

work_stopped

No

GBAA2534

47527824

acetyltransferase [Bacillus anthracis st...

168

CONSERVED

Phase 3: June 2008

3FBU

100%

Bacillus anthracis

N/A

IDP00054
(show subtarget assignments)

1

crystallized

No

BA_3600

30258128

acetyltransferase, CYSE/LACA/LPXA/NODL f...

185

Virulence

Phase 1: October 2007

1KHR

42.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00043
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2629

30257246

acetyltransferase, CYSE/LACA/LPXA/NODL f...

210

Virulence

Phase 1: October 2007

4E8L

63.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02595
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1384c

56708433

acetyltransferase [Francisella tularensi...

163

Drug Target

Phase 3: June 2008

Francisella tularensis

Central intermediary metabolismUnknown function

OtherEnzymes of unknown specificity

IDP00739
(show subtarget assignments)

1

diffraction

No

SACOL1063

57284433

acetyltransferase, GNAT family

144

Drug Target Function

Phase 2: March 2008

1Q2Y

40.3%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP00844
(show subtarget assignments)

1

diffraction

No

SACOL0519

57285544

acetyltransferase, GNAT family

174

Drug Target Function

Phase 2: March 2008

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP91269
(show subtarget assignments)

8

soluble

No

NT05BA2958

49179731

acetyltransferase, GNAT family [Bacillus...

180

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1NSL

30.6%

Bacillus anthracis

Protein synthesis: Ribosomal proteins: synthesis and modification

IDP00661
(show subtarget assignments)

1

purified

No

SACOL0827

57284289

acetyltransferase, putative

161

Drug Target Function

Phase 2: March 2008

1OCX

30.4%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP91546
(show subtarget assignments)

8

in_pdb
4E8L

No

AAA26683

398085

vat

acetyltransferase [Staphylococcus aureus...

219

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

4E8L

100%

Staphylococcus aureus

IDP02744
(show subtarget assignments)

1

cloned

No

FTT0087

56707265

acnA

aconitate hydratase [Francisella tularen...

937

Drug Target

Phase 3: June 2008

3SN2

50.5%

Francisella tularensis

Energy metabolism

TCA cycle

IDP01963
(show subtarget assignments)

1

purified

No

STM1712

16765056

acnA

aconitate hydratase [Salmonella typhimur...

891

Conserved; Drug target functions

Phase 3: June 2008

3SN2

52.3%

Salmonella enterica

Energy metabolism

TCA cycle

IDP02220
(show subtarget assignments)

1

cloned

No

YPO2221

16122450

acnA

aconitate hydratase [Yersinia pestis CO9...

890

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3SN2

52.2%

Yersinia pestis

Energy metabolism

TCA cycle

IDP01843
(show subtarget assignments)

1

cloned

No

lmo0204

16802250

actA

actin-assembly inducing protein precurso...

639

Known virulence-Nucleation-promoting factor; Predicted virulence-Pathogenicity i...

Phase 3: June 2008

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP01025
(show subtarget assignments)

1

cloned

No

STM1196

16764551

acpP

acyl carrier protein

78

Conserved Gene / Pathway

Phase 2: March 2008

1L0H

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02407
(show subtarget assignments)

1

cloned

No

GBAA3988

47529279

acpP

acyl carrier protein [Bacillus anthracis...

77

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2X2B

81.8%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP91643
(show subtarget assignments)

8

cloned

No

NP_215860

15608484

acyl carrier protein [Mycobacterium tube...

106

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

4DXE

19.8%

Mycobacterium tuberculosis

IDP04320
(show subtarget assignments)

1

in_pdb
4ESE

No

YPO2323

115348026

acpD

acyl carrier protein phosphodiesterase [...

201

conserved gene; putative drug target function;

Phase 4: April 2009

1T5B

81.1%

Yersinia pestis

Fatty acid and phospholipid metabolism

Other

IDP01440
(show subtarget assignments)

1

in_pdb
3HJV

No

VC2022

15642024

acyl carrier protein S-malonyltransferas...

312

Drug Target Function

Phase 2: March 2008

3HJV

100%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00426
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1598

16121866

fabD

acyl carrier protein S-malonyltransferas...

309

Conserved Gene / Pathway

Phase 2: March 2008

3H0P

79.3%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00956
(show subtarget assignments)

1

in_pdb
3H0P

No

STM1194

16764549

fabD

acyl carrier protein S-malonyltransferas...

309

potential drug target / Essential Gene

Phase 2: March 2008

3H0P

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00352
(show subtarget assignments)

1

purified

No

lmo1808

16803848

fabD

acyl-carrier-protein S-malonyltransferas...

313

Drug Target Function

Phase 2: March 2008

3IM9

46.6%

Listeria monocytogenes

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02763
(show subtarget assignments)

1

cloned

No

GBAA2547

47527836

acyl-CoA dehydrogenase [Bacillus anthrac...

381

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2VIG

50.4%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP04432
(show subtarget assignments)

1

in_pdb
3OWA

No

GBAA5246

47530551

acyl-CoA dehydrogenase [Bacillus anthrac...

594

conserved gene; putative drug target function;

Phase 4: April 2009

3OWA

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP91645
(show subtarget assignments)

8

soluble

No

NP_215862

15608486

acyl-CoA dehydrogenase [Mycobacterium tu...

386

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

1WS9

27.2%

Mycobacterium tuberculosis

IDP90795
(show subtarget assignments)

8

cloned

No

YPO3244

16123403

fadE

acyl-CoA dehydrogenase [Yersinia pestis ...

815

Predicted Essential

Community Requests

2UXW

18.8%

Yersinia pestis

IDP91636
(show subtarget assignments)

8

cloned

No

NP_217464

15610085

acyl-CoA synthetase [Mycobacterium tuber...

705

virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...

Community Requests

2V7B

23%

Mycobacterium tuberculosis

IDP91647
(show subtarget assignments)

8

cloned

No

NP_217446

57117038

acyl-CoA synthetase [Mycobacterium tuber...

583

virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...

Community Requests

3E53

45.1%

Mycobacterium tuberculosis

IDP91648
(show subtarget assignments)

8

cloned

No

NP_217466

161352463

acyl-CoA synthetase [Mycobacterium tuber...

582

virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...

Community Requests

3E53

44.8%

Mycobacterium tuberculosis

IDP90631
(show subtarget assignments)

8

expressed

No

YPO2526

16122745

acyl-CoA thioester hydrolase YfbB [Yersi...

272

Predicted Essential

Community Requests

1R3D

42.3%

Yersinia pestis

IDP02057
(show subtarget assignments)

1

soluble

No

Cj1311

15792634

neuA2

acylneuraminate cytidylyltransferase [Ca...

232

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...

Phase 3: June 2008

1QWJ

26.3%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02546
(show subtarget assignments)

1

expressed

No

Cj1143

15792468

neuA1

acylneuraminate cytidylyltransferase [Ca...

536

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

1EYR

16.2%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01775
(show subtarget assignments)

1

cloned

No

Cj1331

15792654

ptmB

acylneuraminate cytidylyltransferase (fl...

235

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...

Phase 3: June 2008

1EYR

28.9%

Campylobacter jejuni

Hypothetical proteins

Conserved