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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 5 of 60, showing 100 records out of 5973 total, starting on record 401
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP05085
(
show subtarget assignments
)
1
soluble
No
Z4863
12518151
putative 3-oxoacyl-[ACP] synthase [Esche...
389
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3KZU
31.9%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP05332
(
show subtarget assignments
)
1
soluble
No
Z4866
12518154
putative beta-ketoacyl-ACP synthase [Esc...
409
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
4EWG
59.7%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP05118
(
show subtarget assignments
)
1
cloned
No
Z5902
12519310
putative helicase [Escherichia coli O157...
704
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1PJR
12.8%
Escherichia coli
Protein synthesis: Ribosomal proteins: synthesis and modification
IDP00254
(
show subtarget assignments
)
1
in_pdb
3P54
Yes
13272205
Japanese encephalitis virus Envelope pro...
406
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
3P54
98.3%
Japanese encephalitis
IDP91598
(
show subtarget assignments
)
8
cloned
No
BAB33448
13359481
ECs0025
hypothetical protein [Escherichia coli O...
473
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91599
(
show subtarget assignments
)
8
purified
No
BAB33484
13359517
ECs0061
hypothetical protein [Escherichia coli O...
250
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91560
(
show subtarget assignments
)
8
purified
No
BAB33496
13359529
ECs0073
hypothetical protein [Escherichia coli O...
189
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91561
(
show subtarget assignments
)
8
purified
No
BAB33895
13359929
ECs0472
hypothetical protein [Escherichia coli O...
523
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91563
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAB34270
13360306
ECs0847
hypothetical protein [Escherichia coli O...
330
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91564
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAB34271
13360307
ECs0848
hypothetical protein [Escherichia coli O...
293
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91565
(
show subtarget assignments
)
8
expressed
No
BAB34273
13360309
ECs0850
hypothetical protein [Escherichia coli O...
232
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91562
(
show subtarget assignments
)
8
expressed
No
BAB34299
13360335
ECs0876
hypothetical protein [Escherichia coli O...
670
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3NAW
19.6%
Escherichia coli
IDP91626
(
show subtarget assignments
)
8
cloned
No
BAB34550
13360587
ECs1127
hypothetical protein [Escherichia coli O...
60
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91627
(
show subtarget assignments
)
8
cloned
No
BAB34984
13361025
ECs1561
hypothetical protein [Escherichia coli O...
1133
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91628
(
show subtarget assignments
)
8
soluble
No
BAB34989
13361030
ECs1566
hypothetical protein [Escherichia coli O...
57
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91629
(
show subtarget assignments
)
8
expressed
No
BAB34990
13361031
ECs1567
hypothetical protein [Escherichia coli O...
91
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91566
(
show subtarget assignments
)
8
cloned
No
BAB34991
13361032
ECs1568
hypothetical protein [Escherichia coli O...
453
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91630
(
show subtarget assignments
)
8
cloned
No
BAB35233
13361275
ECs1810
hypothetical protein [Escherichia coli O...
88
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91567
(
show subtarget assignments
)
8
cloned
No
BAB35235
13361277
ECs1812
hypothetical protein [Escherichia coli O...
441
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91568
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAB35237
13361279
ECs1814
hypothetical protein [Escherichia coli O...
303
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91569
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAB35238
13361280
ECs1815
hypothetical protein [Escherichia coli O...
189
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91631
(
show subtarget assignments
)
8
expressed
No
BAB35244
13361286
ECs1821
hypothetical protein [Escherichia coli O...
92
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91570
(
show subtarget assignments
)
8
expressed
No
BAB35247
13361289
ECs1824
hypothetical protein [Escherichia coli O...
215
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
17.7%
Escherichia coli
IDP91632
(
show subtarget assignments
)
8
purified
No
BAB35248
13361290
ECs1825
bfpT-regulated chaperone-like protein [E...
196
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3LW8
39.8%
Escherichia coli
IDP91571
(
show subtarget assignments
)
8
expressed
No
BAB35251
13361293
ECs1828
hypothetical protein [Escherichia coli O...
169
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
25.4%
Escherichia coli
IDP91633
(
show subtarget assignments
)
8
purified
No
BAB35418
13361460
ECs1995
hypothetical protein [Escherichia coli O...
209
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
20.1%
Escherichia coli
IDP91572
(
show subtarget assignments
)
8
soluble
No
BAB35419
13361461
ECs1996
hypothetical protein [Escherichia coli O...
213
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
20.2%
Escherichia coli
IDP91625
(
show subtarget assignments
)
8
soluble
No
BAB35496
13361539
ECs2073
hypothetical protein [Escherichia coli O...
419
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3RG1
17.2%
Escherichia coli
IDP91624
(
show subtarget assignments
)
8
expressed
No
BAB35497
13361540
ECs2074
hypothetical protein [Escherichia coli O...
222
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91573
(
show subtarget assignments
)
8
soluble
No
BAB35577
13361620
ECs2154
hypothetical protein [Escherichia coli O...
213
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
19.7%
Escherichia coli
IDP91574
(
show subtarget assignments
)
8
soluble
No
BAB35578
13361621
ECs2155
hypothetical protein [Escherichia coli O...
209
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
19.6%
Escherichia coli
IDP91621
(
show subtarget assignments
)
8
soluble
No
BAB35649
13361692
ECs2226
hypothetical protein [Escherichia coli O...
123
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
35%
Escherichia coli
IDP91622
(
show subtarget assignments
)
8
expressed
No
BAB35650
13361693
ECs2227
hypothetical protein [Escherichia coli O...
115
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91623
(
show subtarget assignments
)
8
expressed
No
BAB35652
13361695
ECs2229
hypothetical protein [Escherichia coli O...
169
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
39.1%
Escherichia coli
IDP91620
(
show subtarget assignments
)
8
expressed
No
BAB35850
13361894
ECs2427
hypothetical protein [Escherichia coli O...
632
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91619
(
show subtarget assignments
)
8
soluble
No
BAB36095
13362140
ECs2672
hypothetical protein [Escherichia coli O...
379
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1G9U
13.5%
Escherichia coli
IDP91618
(
show subtarget assignments
)
8
expressed
No
BAB36097
13362142
ECs2674
hypothetical protein [Escherichia coli O...
379
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1G9U
13.7%
Escherichia coli
IDP91615
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAB36137
13362182
ECs2714
hypothetical protein [Escherichia coli O...
217
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91616
(
show subtarget assignments
)
8
soluble
No
BAB36138
13362183
ECs2715
EspF-like protein [Escherichia coli O157...
337
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KXC
13.9%
Escherichia coli
IDP91617
(
show subtarget assignments
)
8
purified
No
BAB36908
13362956
ECs3485
chaperone-like protein [Escherichia coli...
196
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3LW8
41.3%
Escherichia coli
IDP91614
(
show subtarget assignments
)
8
purified
No
BAB36909
13362957
ECs3486
hypothetical protein [Escherichia coli O...
216
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
14.4%
Escherichia coli
IDP91613
(
show subtarget assignments
)
8
soluble
No
BAB36910
13362958
ECs3487
hypothetical protein [Escherichia coli O...
352
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91612
(
show subtarget assignments
)
8
purified
No
BAB36911
13362959
ECs3488
hypothetical protein [Escherichia coli O...
140
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
27.1%
Escherichia coli
IDP91611
(
show subtarget assignments
)
8
expressed
No
BAB37278
13363327
ECs3855
putative enterotoxin [Escherichia coli O...
549
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91575
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAB37280
13363329
ECs3857
hypothetical protein [Escherichia coli O...
329
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91576
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAB37281
13363330
ECs3858
hypothetical protein [Escherichia coli O...
224
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91577
(
show subtarget assignments
)
8
purified
No
BAB37973
13364025
ECs4550
EspF protein [Escherichia coli O157:H7 s...
248
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91610
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAB37977
13364029
ECs4554
EspB protein [Escherichia coli O157:H7 s...
312
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91578
(
show subtarget assignments
)
8
cloned
No
BAB37984
13364036
ECs4561
translocated intimin receptor Tir [Esche...
558
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2ZQK
12.2%
Escherichia coli
IDP91579
(
show subtarget assignments
)
8
soluble
No
BAB37987
13364039
ECs4564
hypothetical protein [Escherichia coli O...
168
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91557
(
show subtarget assignments
)
8
purified
No
BAB38065
13364117
ECs4642
hypothetical protein [Escherichia coli O...
76
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91558
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAB38076
13364128
ECs4653
hypothetical protein [Escherichia coli O...
802
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91559
(
show subtarget assignments
)
8
expressed
No
BAB38077
13364129
ECs4654
hypothetical protein [Escherichia coli O...
223
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91556
(
show subtarget assignments
)
8
expressed
No
BAB38080
13364132
ECs4657
hypothetical protein [Escherichia coli O...
794
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91555
(
show subtarget assignments
)
8
expressed
No
BAB38358
13364411
ECs4935
regulator of acetyl CoA synthetase [Esch...
728
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91554
(
show subtarget assignments
)
8
expressed
No
BAB38444
13364498
ECs5021
hypothetical protein [Escherichia coli O...
526
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3NAW
20.9%
Escherichia coli
IDP91553
(
show subtarget assignments
)
8
expressed
No
BAB38471
13364525
ECs5048
hypothetical protein [Escherichia coli O...
430
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2J8K
10.5%
Escherichia coli
IDP91552
(
show subtarget assignments
)
8
expressed
No
BAB38718
13364773
ECs5295
hypothetical protein [Escherichia coli O...
735
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3DU1
9.1%
Escherichia coli
IDP91589
(
show subtarget assignments
)
8
expressed
No
BAB41266
13699967
ermA
rRNA methylase [Staphylococcus aureus su...
243
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1QAM
56.8%
Staphylococcus aureus
IDP91722
(
show subtarget assignments
)
8
selected
No
NP_112420
14043070
HNRNPA1
heterogeneous nuclear ribonucleoprotein ...
372
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1L3K
52.7%
Homo sapiens
IDP91723
(
show subtarget assignments
)
8
selected
No
NP_112552
14165435
HNRNPK
heterogeneous nuclear ribonucleoprotein ...
463
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1J5K
18.6%
Homo sapiens
IDP91254
(
show subtarget assignments
)
8
soluble
No
NT02SA0910
14246689
probable 2-nitropropane dioxygenase [Sta...
355
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3BW2
34.9%
Staphylococcus aureus
Cellular processes: Detoxification
IDP91255
(
show subtarget assignments
)
8
soluble
No
NT02SA0971
14246752
fabH
3-oxoacyl-#acyl-carrier protein synthase...
313
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1ZOW
100%
Staphylococcus aureus
Fatty acid and phospholipid metabolism: Biosynthesis
IDP91256
(
show subtarget assignments
)
8
cloned
No
NT02SA0972
14246753
3-oxoacyl synthase [Staphylococcus aureu...
414
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2GQD
99.8%
Staphylococcus aureus
Energy metabolism: ATP-proton motive force interconversion
IDP91257
(
show subtarget assignments
)
8
soluble
No
NT02SA1359
14247140
trpD
anthranilate phosphoribosyltransferase [...
332
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1VQU
33.8%
Staphylococcus aureus
Amino acid biosynthesis: Aromatic amino acid family
IDP91258
(
show subtarget assignments
)
8
soluble
No
NT02SA1455
14247237
aroC
chorismate synthase [Staphylococcus aure...
388
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1QXO
56.7%
Staphylococcus aureus
Amino acid biosynthesis: Aromatic amino acid family
IDP91259
(
show subtarget assignments
)
8
soluble
No
NT02SA1746
14247541
ribA
riboflavin biosynthesis protein [Staphyl...
393
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3MGZ
24.2%
Staphylococcus aureus
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
IDP91260
(
show subtarget assignments
)
8
soluble
No
NT02SA2397
14248172
nasF
uroporphyrin-III C-methyl transferase [S...
325
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1PJQ
28%
Staphylococcus aureus
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
IDP91726
(
show subtarget assignments
)
8
selected
No
NP_116784
14670388
BAD
bcl2 antagonist of cell death [Homo sapi...
168
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2BZW
14.9%
Homo sapiens
IDP91664
(
show subtarget assignments
)
8
selected
No
NP_055232
15193488
BBC3
bcl-2-binding component 3 isoform 4 [Hom...
193
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2ROC
12.4%
Homo sapiens
IDP91710
(
show subtarget assignments
)
8
selected
No
NP_006353
15487670
NXF1
nuclear RNA export factor 1 isoform 1 [H...
619
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1KOO
44.6%
Homo sapiens
IDP91590
(
show subtarget assignments
)
8
cloned
No
PA0920
15596117
hypothetical protein PA0920 [Pseudomonas...
881
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Pseudomonas aeruginosa
IDP91172
(
show subtarget assignments
)
8
purified
No
PA1706
15596903
pcrV
type III secretion protein PcrV [Pseudom...
294
potential drug target /
P. aeruginosa is an important clinical pathogen. PcrV is a critical component (t...
Community Requests
1R6F
35.4%
Pseudomonas aeruginosa
IDP01479
(
show subtarget assignments
)
1
expressed
No
VCA0064
15600835
TonB system receptor, putative
713
Conserved Gene / Pathway
Phase 2: March 2008
1NQF
22.6%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP04179
(
show subtarget assignments
)
1
cloned
No
VCA0068
15600839
methyl-accepting chemotaxis protein [Vib...
547
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3ZX6
18.3%
Vibrio cholerae
Cellular processes
Chemotaxis and motility
IDP01340
(
show subtarget assignments
)
1
expressed
No
VCA0073
15600844
phosphate ABC transporter, ATP-binding p...
251
Conserved Gene / Pathway
Phase 2: March 2008
2OLJ
37.1%
Vibrio cholerae
Transport and binding proteins
Anions
IDP01480
(
show subtarget assignments
)
1
cloned
No
VCA0116
15600887
clpB protein
869
Drug Target Function
Phase 2: March 2008
1QVR
36.4%
Vibrio cholerae
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP01508
(
show subtarget assignments
)
1
expressed
No
VCA0127
15600898
ribose ABC transporter protein
156
Conserved Gene / Pathway
Phase 2: March 2008
3DSA
48.1%
Vibrio cholerae
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP01481
(
show subtarget assignments
)
1
expressed
No
VCA0130
15600901
D-ribose transporter subunit RbsB
294
Conserved Gene / Pathway
Phase 2: March 2008
1DBP
65.3%
Vibrio cholerae
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP04180
(
show subtarget assignments
)
1
expressed
No
VCA0141
15600911
C4-dicarboxylate transport sensor protei...
684
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3JZ3
9.9%
Vibrio cholerae
Regulatory functions
Other
IDP01482
(
show subtarget assignments
)
1
in_pdb
3QU1
No
VCA0150
15600920
def
peptide deformylase
168
Conserved Gene / Pathway
Phase 2: March 2008
3QU1
100%
Vibrio cholerae
Protein fate
Protein modification and repair
IDP01483
(
show subtarget assignments
)
1
in_crystallization_trials
No
VCA0180
15600950
peptidase T
410
Drug Target Function
Phase 2: March 2008
1VIX
57.6%
Vibrio cholerae
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP01484
(
show subtarget assignments
)
1
in_pdb
4EH1
No
VCA0183
15600953
nitric oxide dioxygenase
394
Conserved Gene / Pathway
Phase 2: March 2008
4EH1
61.7%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP90843
(
show subtarget assignments
)
8
in_pdb
3Q4G
Yes
VCA0207
15600976
nadE
NAD synthetase [Vibrio cholerae O1 biova...
276
Predicted Essential
Community Requests
3Q4G
99.6%
Vibrio cholerae
IDP04375
(
show subtarget assignments
)
1
expressed
No
VCA0211
15600980
sensory box sensor histidine kinase [Vib...
648
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3D36
9.7%
Vibrio cholerae
Regulatory functions
Other
IDP00169
(
show subtarget assignments
)
1
expressed
No
VCA0218
15600987
No Data
thermolabile hemolysin
418
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01348
(
show subtarget assignments
)
0
work_stopped
No
VCA0219
15600988
haemolysin
741
Conserved Gene / Pathway
Phase 2: March 2008
1XEZ
94.7%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01485
(
show subtarget assignments
)
1
soluble
No
VCA0220
15600989
hemolysin secretion protein HylB
548
Conserved Gene / Pathway
Phase 2: March 2008
3ZX6
16.4%
Vibrio cholerae
Transport and binding proteins
Other
IDP00148
(
show subtarget assignments
)
1
soluble
No
VCA0227
15600996
vctP
vibriobactin and enterobactin ABC transp...
333
Virulence
Phase 1: October 2007
3GFV
30.3%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP00149
(
show subtarget assignments
)
1
expressed
No
VCA0230
15600999
vctC
vibriobactin and enterobactin ABC transp...
254
Virulence
Phase 1: October 2007
2D62
28%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP04182
(
show subtarget assignments
)
1
cloned
No
VCA0238
15601006
sensor histidine kinase [Vibrio cholerae...
549
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
12%
Vibrio cholerae
Regulatory functions
Other
IDP01486
(
show subtarget assignments
)
1
in_pdb
3IEB
3JR2
No
VCA0242
15601010
ulaD
3-keto-L-gulonate-6-phosphate decarboxyl...
215
Conserved Gene / Pathway
Phase 2: March 2008
3IEB
100%
Vibrio cholerae
Energy metabolism
Sugars
IDP01349
(
show subtarget assignments
)
1
purified
No
VCA0253
15601021
antibiotic acetyltransferase
232
Drug Target Function
Phase 2: March 2008
3EEV
37.1%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP04183
(
show subtarget assignments
)
1
expressed
No
VCA0257
15601025
sensor histidine kinase [Vibrio cholerae...
484
drug target; putative drug target function;
Phase 4: April 2009
Vibrio cholerae
Regulatory functions
Other
IDP01487
(
show subtarget assignments
)
1
soluble
No
VCA0270
15601038
D-alanyl-D-alanine carboxypeptidase
389
Drug Target Function
Phase 2: March 2008
1NZO
44.5%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP90813
(
show subtarget assignments
)
8
in_crystallization_trials
No
VCA0287
15601053
threonyl-tRNA synthetase [Vibrio cholera...
642
Predicted Essential
Community Requests
1QF6
75.6%
Vibrio cholerae
IDP01350
(
show subtarget assignments
)
1
in_pdb
3EEV
No
VCA0300
15601065
chloramphenicol acetyltransferase
209
Drug Target Function
Phase 2: March 2008
3EEV
100%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP01351
(
show subtarget assignments
)
1
cloned
No
VCA0387
15601150
toxin resistance protein
169
Conserved Gene / Pathway
Phase 2: March 2008
1YVO
31.4%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP91763
(
show subtarget assignments
)
8
purified
No
VCA0439
15601202
microcin immunity protein MccF [Vibrio c...
334
drug resistance; innate immunity /
Vibrio Cholerae MccF-like (MccF homolog) - E.coli MccF confers immunity to micro...
Community Requests
3TLA
57.1%
Vibrio cholerae
IDP01313
(
show subtarget assignments
)
1
purified
No
VCA0446
15601209
haemagglutinin
63
Virulence Associated Factor
Phase 2: March 2008
Vibrio cholerae
Cellular processes
Pathogenesis
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