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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 5 of 60, showing 100 records out of 5973 total, starting on record 401
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP90193
(
show subtarget assignments
)
8
cloned
No
AAM13637.1
20153176
CPXV198 CDS
CPXV198 protein
558
ankyrin-like protein
Community Requests
1N11
11.1%
Cowpox virus
conserved hypothetical proteins
0
IDP90540
(
show subtarget assignments
)
8
in_pdb
3THA
No
Cj0349
15791717
trpA
tryptophan synthase subunit alpha [Campy...
249
Predicted Essential
Community Requests
3THA
100%
Campylobacter jejuni
IDP90195
(
show subtarget assignments
)
8
soluble
No
AAM13642.1
20153181
CPXV203 CDS
CPXV203 protein
225
ER-localized, MHC-I inhibitor
Community Requests
Cowpox virus
host defense modulator
0
IDP90198
(
show subtarget assignments
)
8
expressed
No
AAM13648.1
20153187
CPXV209
CPXV209 protein
326
soluble secreted IL-1 binding protein
Community Requests
3O4O
28.5%
Cowpox virus
host defense modulator
0
IDP90197
(
show subtarget assignments
)
8
soluble
No
AAM13645.1
20153184
CPXV206 CDS
CPXV206 protein
285
serine-threonine kinase
Community Requests
2KTY
32.1%
Cowpox virus
Unknown function
0
IDP90196
(
show subtarget assignments
)
8
cloned
No
AAM13643.1
20153182
CPXV204 CDS
CPXV204 protein
501
kelch-like protein
Community Requests
2VPJ
14%
Cowpox virus
conserved hypothetical proteins
0
IDP90202
(
show subtarget assignments
)
8
cloned
No
AAM13655.1
20153194
CPXV217 CDS
CPXV217 protein
372
serine-protease inhibitor (SPI-1)
Community Requests
1F0C
40.9%
Cowpox virus
host defense modulator
0
IDP90207
(
show subtarget assignments
)
8
soluble
No
MYXV_gp152
9633784
m149R
m149R
490
ankyrin motif, similar to VACV-Cop:B4R
Community Requests
1N11
14.9%
Myxoma virus
host range factor
0
IDP90201
(
show subtarget assignments
)
8
cloned
No
AAM13653.1
20153192
CPXV215 CDS
CPXV215 Protein
557
kelch-like protein
Community Requests
2VPJ
12.2%
Cowpox virus
conserved hypothetical proteins
0
IDP90200
(
show subtarget assignments
)
8
purified
No
AAM13652.1
20153191
CPXV213 CDS
CPXV213 protein
800
ankyrin-like protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP90203
(
show subtarget assignments
)
8
selected
No
AAM13658.1
20153197
CPXV220 CDS
CPXV220 protein
579
ankyrin-like protein
Community Requests
2FO1
10.4%
Cowpox virus
conserved hypothetical proteins
0
IDP90206
(
show subtarget assignments
)
8
soluble
No
MYXV_gp149
9633781
m146R
m146R
108
virokine/NFkB inh/Str resemblence to apoptotic reg, similar to VACV-Cop:N1L
Community Requests
2I39
26.9%
Myxoma virus
host defense modulator
0
IDP90205
(
show subtarget assignments
)
8
expressed
No
AAM13465.1
20153004
CPXV018 CDS
CPXV018 protein, VO18
171
similar to MPV-Z-N3R
Community Requests
Cowpox virus
host defense modulator
0
IDP90204
(
show subtarget assignments
)
8
cloned
No
AAM13452.1
20152991
CPXV006 CDS
CPXV006 protein
619
ankyrin repeat protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP90210
(
show subtarget assignments
)
8
expressed
No
MYXV_gp140
9633772
m136R
m136R
179
unknown, similar to VACV-Cop:A52R
Community Requests
2VVW
20.1%
Myxoma virus
unknown, conserved protein
0
IDP90215
(
show subtarget assignments
)
8
expressed
No
MYXV_gp009
9633800
m006L
m006L, m6
509
contains kelch motifs, similar to MYX-L-m006R
Community Requests
1X2J
13.9%
Myxoma virus
unknown
0
IDP90256
(
show subtarget assignments
)
8
crystallized
No
SAR0409
49482642
guaA
bifunctional GMP synthase/glutamine amid...
513
(From requestor) Identified potential S. aureus drug target. Would like to devel...
Community Requests
1GPM
51.2%
Staphylococcus aureus
IDP90556
(
show subtarget assignments
)
8
cloned
No
YPO1056
16121356
lpxA
UDP-N-acetylglucosamine acyltransferase
262
Predicted Essential
Community Requests
1LXA
81.7%
Yersinia pestis
IDP90211
(
show subtarget assignments
)
8
cloned
No
MYXV_gp132
9633764
m128L
m128L
281
integrin-associated protein homolog similar to VACV-Cop:A38L. Five pass TM prote...
Community Requests
Myxoma virus
host defense modulator
0
IDP90214
(
show subtarget assignments
)
8
expressed
No
MYXV_gp017
9633649
m013L
m013L, M013L
126
interferon inducible protein
Community Requests
Myxoma virus
unknown
0
IDP90213
(
show subtarget assignments
)
8
purified
No
MYXV_gp033
9633665
m029L
m029L, m29L
115
IFN resistance, PKR inhibitor
Community Requests
2YT4
19.1%
Myxoma virus
host range factor, host defense modulator
0
IDP90212
(
show subtarget assignments
)
8
cloned
No
MYXV_gp067
9633699
m063R
m063R, m63R
215
CD47-likeÂ
Community Requests
Myxoma virus
host range factor, host defense modulator
0
IDP90218
(
show subtarget assignments
)
8
soluble
No
MYXV_gp151
9633783
m148R
m148R
675
ankyrin motif, similar to VACV-Cop:B4R
Community Requests
2J8S
6.1%
Myxoma virus
host range factor
0
IDP90563
(
show subtarget assignments
)
8
soluble
No
VC0061
15640093
thiamine biosynthesis protein ThiC [Vibr...
645
Predicted Essential
Community Requests
3EPM
65%
Vibrio cholerae
IDP90217
(
show subtarget assignments
)
8
soluble
No
MYXV_gp004
9633795
m003.1L
m003.1L, m3.1
151
similar to VACV-Cop:B22R, member of Poxvirus A4/B15 family. This is a family of ...
Community Requests
2VVY
29.8%
Myxoma virus
unknown
0
IDP90216
(
show subtarget assignments
)
8
expressed
No
MYXV_gp008
9633799
m005L
m005L, m5, M-T5
483
ankyrin motif, similar to VACV-Cop:B4R. Possible apoptosis regulator.
Community Requests
1N0R
8.5%
Myxoma virus
host range factor, host defense modulator
0
IDP90219
(
show subtarget assignments
)
8
expressed
No
MYXV_gp011
9633802
m008L
m008L, m8
515
contains kelch motifs, similar to MYX-L-m006R
Community Requests
2XN4
11.5%
Myxoma virus
unknown
0
IDP90566
(
show subtarget assignments
)
8
in_pdb
3QBO
No
YPO1389
16121669
serC
phosphoserine aminotransferase [Yersinia...
361
Predicted Essential
Community Requests
3QBO
96.7%
Yersinia pestis
IDP90221
(
show subtarget assignments
)
8
cloned
No
MYXV_gp157
9633790
m154L
m154L, gp120-like
214
NFkB inhibitor, similar to VACV-Cop:M2L
Community Requests
Myxoma virus
host defense modulator
0
IDP90220
(
show subtarget assignments
)
8
selected
No
MYXV_gp153
9633785
m150R
m150R
494
ankyrin-like protein, myxoma nuclear factor
Community Requests
Myxoma virus
host range factor
0
IDP90255
(
show subtarget assignments
)
8
purified
No
SAR1777
49483940
pfkA
6-phosphofructokinase [Staphylococcus au...
322
(From requester) Identified as potential drug target for S. aureus MRSA. Am curr...
Community Requests
3U39
59.3%
Staphylococcus aureus
IDP90245
(
show subtarget assignments
)
8
selected
No
SF2514
24113800
dapE
succinyl-diaminopimelate desuccinylase [...
375
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3IC1
61.6%
Shigella flexneri
IDP90225
(
show subtarget assignments
)
8
in_pdb
3K29
No
CT670
3329121
Hypothetical
168
Chlamydia type III secretion associated protein CT670
Community Requests
3K29
100%
Chlamydia trachomatis
IDP90571
(
show subtarget assignments
)
8
expressed
No
YPO0416
16120749
putative lipopolysaccharide core biosynt...
346
Predicted Essential
Community Requests
3TOV
24.9%
Yersinia pestis
IDP90574
(
show subtarget assignments
)
8
in_pdb
3NX3
No
Cj0227
15791599
argD
acetylornithine aminotransferase [Campyl...
395
Predicted Essential
Community Requests
3NX3
100%
Campylobacter jejuni
IDP90244
(
show subtarget assignments
)
8
expressed
No
YPO3053
218930098
dapE
succinyl-diaminopimelate desuccinylase [...
375
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3IC1
63.2%
Yersinia pestis
IDP90242
(
show subtarget assignments
)
8
expressed
No
SA1814
15927582
succinyl-diaminopimelate desuccinylase [...
407
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3TX8
25.5%
Staphylococcus aureus
IDP90575
(
show subtarget assignments
)
8
soluble
No
YPO2610
16122823
leuS
leucyl-tRNA synthetase [Yersinia pestis ...
860
Predicted Essential
Community Requests
1H3N
46.7%
Yersinia pestis
IDP90248
(
show subtarget assignments
)
8
purified
No
BAS0467
49183495
acetylornithine deacetylase [Bacillus an...
426
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3PFO
27%
Bacillus anthracis
IDP90254
(
show subtarget assignments
)
8
selected
No
AAK67494
21263110
ie1
IE1 protein [Human herpesvirus 6]
1078
(From requester) The IE1 protein of HHV-6, one of the first viral proteins synth...
Community Requests
Human herpesvirus
IDP90247
(
show subtarget assignments
)
8
purified
No
YPO3928
115349537
argE
acetylornithine deacetylase [Yersinia pe...
389
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3PFO
26%
Yersinia pestis
IDP90246
(
show subtarget assignments
)
8
in_pdb
3T68
3T6M
Yes
VC2152
15642151
succinyl-diaminopimelate desuccinylase [...
377
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3T68
70%
Vibrio cholerae
IDP90249
(
show subtarget assignments
)
8
soluble
No
VC2645
15642640
acetylornithine deacetylase [Vibrio chol...
378
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2F7V
26.8%
Vibrio cholerae
IDP90253
(
show subtarget assignments
)
0
work_stopped
No
SAR1776
49483939
pyk
pyruvate kinase [Staphylococcus aureus s...
585
(From requester) Potential drug target
Community Requests
3T05
100%
Staphylococcus aureus
IDP90251
(
show subtarget assignments
)
8
expressed
No
SF4034
56480493
argE
acetylornithine deacetylase [Shigella fl...
383
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2F7V
25.1%
Shigella flexneri
IDP90250
(
show subtarget assignments
)
8
expressed
No
Z5515
15804553
argE
acetylornithine deacetylase [Escherichia...
383
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3IC1
26.9%
Escherichia coli
IDP90258
(
show subtarget assignments
)
8
in_pdb
3KY7
No
SAR1216
49483403
trmD
putative tRNA (guanine-7-)-methyltransfe...
245
Potential drug target
Community Requests
3KY7
100%
Staphylococcus aureus
IDP90274
(
show subtarget assignments
)
8
selected
No
TGME49_015260
211968509
carbamoyl phosphate synthetase II [Toxop...
1699
Mutation of the rate-limiting enzyme carbamoyl phosphate synthetase II (CPSII) d...
Community Requests
1A9X
27.1%
Toxoplasma gondii
IDP90302
(
show subtarget assignments
)
0
work_stopped
No
BB_0420
2688313
sensory transduction histidine kinase, p...
1494
Mutational studies suggest that Hk1 is required for the survival of the Lyme dis...
Community Requests
3A0R
5.6%
Borrelia burgdorferi
IDP90335
(
show subtarget assignments
)
8
soluble
No
CT_652.1
3522906
hypothetical protein [Chlamydia trachoma...
59
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90267
(
show subtarget assignments
)
8
purified
No
TP_0326
3322602
Treponema pallidum subsp. pallidum str. ...
853
From requestor: The structural characterization of Tp0326 will be helpful in at ...
Community Requests
3EFC
11.6%
Treponema pallidum
IDP90273
(
show subtarget assignments
)
8
cloned
No
TGME49_013900
211968791
regulator of chromosome condensation, pu...
1155
Signature-tagged mutagenesis (STM) has identified the regulator of chromosome co...
Community Requests
3MVD
11.1%
Toxoplasma gondii
IDP90272
(
show subtarget assignments
)
8
cloned
No
TGME49_111670
211962063
hypothetical protein TGME49_111670 [Toxo...
440
Unpublished data from signature-tagged mutagenesis (STM) has identified this sur...
Community Requests
Toxoplasma gondii
IDP90271
(
show subtarget assignments
)
8
in_pdb
3M5R
3M8A
No
ACP44186
227977167
NS1
nonstructural protein 1 [Influenza A vir...
219
swine flu virus
Community Requests
3F5T
79.9%
Influenza A
IDP90277
(
show subtarget assignments
)
8
soluble
No
TGME49_059690
211962827
orotidine-monophosphate-decarboxylase, p...
320
The orotidine monophosphate decarboxylase (TgODCase) is the last step in de novo...
Community Requests
3QW3
39.1%
Toxoplasma gondii
IDP90284
(
show subtarget assignments
)
8
expressed
No
TGME49_070250
211963365
dense granule protein 1 / major antigenp...
190
GRA1 is secreted from dense granule as one of the few soluble proteins that can ...
Community Requests
Toxoplasma gondii
IDP90276
(
show subtarget assignments
)
8
cloned
No
TGME49_032600
211965793
patatin-like phospholipase domain-contai...
664
Signature-tagged mutagenesis (STM) has identified this patatin-like phospholipas...
Community Requests
Toxoplasma gondii
IDP90275
(
show subtarget assignments
)
8
soluble
No
TGME49_030450
211965620
GMP synthase, putative [Toxoplasma gondi...
569
Guanosine monophosphate synthetase is essential for the synthesis of GMP in puri...
Community Requests
1GPM
51%
Toxoplasma gondii
IDP90278
(
show subtarget assignments
)
8
crystallized
No
TGME49_003450
211965291
hypothetical protein, conserved [Toxopla...
227
Unpublished data from signature-tagged mutagenesis (STM) has identified this nov...
Community Requests
2PD0
41.9%
Toxoplasma gondii
IDP90283
(
show subtarget assignments
)
8
cloned
No
TGME49_075440
211969603
GRA6
granule antigen protein GRA6 [Toxoplasma...
224
GRA6 is a secreted dense granule protein that generates protective immunity, e.g...
Community Requests
Toxoplasma gondii
IDP90282
(
show subtarget assignments
)
8
selected
No
TGME49_013640
211968765
splicing factor, arginine/serine-rich 4,...
1461
Unpublished data from a differentiation mutagenesis screen indicate that the spl...
Community Requests
Toxoplasma gondii
IDP90280
(
show subtarget assignments
)
8
selected
No
TGME49_004420
211965378
oocyst wall protein COWP, putative [Toxo...
499
Unpublished data from a differentiation mutagenesis screen indicate that the ooc...
Community Requests
1N7D
19%
Toxoplasma gondii
IDP90287
(
show subtarget assignments
)
8
purified
No
TGME49_021210
211967615
18 kDa cyclophilin [Toxoplasma gondii ME...
179
Parasite cyclophilin 18 (TgC18) is an agonist of chemokine receptor CCR5 on T c...
Community Requests
1AK4
53.6%
Toxoplasma gondii
IDP90292
(
show subtarget assignments
)
8
cloned
No
TGGT1_004130
221483205
histone acetyltransferase GCN5, putative...
1169
The histone acetyltransferase TgGCN-5A acetylates prerentially Histone 3 [K18], ...
Community Requests
1Z4R
8.5%
Toxoplasma gondii
IDP90286
(
show subtarget assignments
)
8
in_pdb
3UKS
No
TGME49_035700
211966629
sedoheptulose-1,7 bisphosphatase, putati...
330
Unpublished data indicate that the Calvin cycle enzyme sedoheptulose-1,7-bisphos...
Community Requests
3UKS
100%
Toxoplasma gondii
IDP90603
(
show subtarget assignments
)
8
selected
No
VC0015
15640047
gyrB
DNA gyrase subunit B [Vibrio cholerae O1...
805
Predicted Essential
Community Requests
1EI1
39.6%
Vibrio cholerae
IDP90288
(
show subtarget assignments
)
0
work_stopped
No
TGME49_093690
211967835
profilin family protein [Toxoplasma gond...
163
Parasite profilin is indispensable for gliding motility, host cell invasion, act...
Community Requests
3NEC
100%
Toxoplasma gondii
IDP90291
(
show subtarget assignments
)
8
soluble
No
TGME49_081900
211969063
high mobility group (HMG) box domain-con...
880
The newly described histone lysine methyl-transferase KMTox targets histones H4 ...
Community Requests
Toxoplasma gondii
IDP90290
(
show subtarget assignments
)
8
purified
No
TGME49_019520
211968370
arginine N-methyltransferase 1 [Toxoplas...
392
The histone arginine methyl-transferase TgPRMT1 methylates histone 4 (R3). Whe...
Community Requests
1OR8
44.9%
Toxoplasma gondii
IDP90289
(
show subtarget assignments
)
8
purified
No
TGME49_094270
211967870
arginine methyltransferase protein, puta...
660
Epigenetic is an emerging field in Toxoplasma biology that will provide new targ...
Community Requests
2Y1W
24.5%
Toxoplasma gondii
IDP90295
(
show subtarget assignments
)
8
cloned
No
TGME49_005290
211965425
dual-specificity phosphatase laforin, pu...
523
Human Lafora disease is one of five major progressive myoclonus epilepsies that ...
Community Requests
Toxoplasma gondii
IDP90300
(
show subtarget assignments
)
8
in_pdb
4EIV
3QYQ
Yes
TGME49_118750
211967477
deoxyribose-phosphate aldolase, putative...
286
The deoxyribose phosphate aldolase-like gene TgPDA is recently described to be s...
Community Requests
3QYQ
96.5%
Toxoplasma gondii
IDP90294
(
show subtarget assignments
)
8
expressed
No
TGME49_113230
211962198
eukaryotic translation initiation factor...
347
Under stress conditions, the initiation factor 2a (TgIF2a) is phosphorylated to ...
Community Requests
1Q8K
40.3%
Toxoplasma gondii
IDP90293
(
show subtarget assignments
)
8
in_pdb
3OTR
No
TGME49_068860
211963243
enolase 1 [Toxoplasma gondii ME49]
444
Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...
Community Requests
3OTR
100%
Toxoplasma gondii
IDP90296
(
show subtarget assignments
)
8
purified
No
TGME49_068850
211963242
enolase 2 [Toxoplasma gondii ME49]
475
Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...
Community Requests
3OTR
68.8%
Toxoplasma gondii
IDP90299
(
show subtarget assignments
)
8
selected
No
TGME49_007160
211969665
Toxoplasma gondii bradyzoite SAG2 relate...
364
The Toxoplasma gondii surface is dominated by a large class of GPI-anchored prot...
Community Requests
2JKS
14%
Toxoplasma gondii
IDP90298
(
show subtarget assignments
)
8
selected
No
TGME49_120190
211967550
bradyzoite-specific surface protein, put...
398
TgSRS9 is one of the few in the SAG1 family that is expressed only in bradyzoite...
Community Requests
2JKS
37.7%
Toxoplasma gondii
IDP90297
(
show subtarget assignments
)
8
purified
No
TGME49_065450
211966338
hexokinase [Toxoplasma gondii ME49]
468
Hexokinase (TgHK) is one of 5 major glycolytic enzymes characterized in Toxoplas...
Community Requests
1CZA
34.7%
Toxoplasma gondii
IDP90306
(
show subtarget assignments
)
8
cloned
No
CT_694
3329148
hypothetical protein [Chlamydia trachoma...
323
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90311
(
show subtarget assignments
)
8
cloned
No
CT_734
3329192
hypothetical protein [Chlamydia trachoma...
221
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90305
(
show subtarget assignments
)
8
cloned
No
CT_681
3329133
ompA
Major Outer Membrane Protein [Chlamydia ...
393
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90304
(
show subtarget assignments
)
8
soluble
No
CT_671
3329122
hypothetical protein [Chlamydia trachoma...
283
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90307
(
show subtarget assignments
)
8
cloned
No
CT_695
3329149
hypothetical protein [Chlamydia trachoma...
398
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90310
(
show subtarget assignments
)
8
expressed
No
CT_716
3329172
hypothetical protein [Chlamydia trachoma...
121
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90309
(
show subtarget assignments
)
8
cloned
No
CT_702
3329157
hypothetical protein [Chlamydia trachoma...
175
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90308
(
show subtarget assignments
)
8
cloned
No
CT_700
3329154
hypothetical protein [Chlamydia trachoma...
441
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1NA0
6.3%
Chlamydia trachomatis
IDP90312
(
show subtarget assignments
)
8
expressed
No
CT_712
3329168
hypothetical protein [Chlamydia trachoma...
390
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90315
(
show subtarget assignments
)
8
cloned
No
CT_744
3329204
CHLTR possible phosphoprotein [Chlamydia...
821
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90314
(
show subtarget assignments
)
8
soluble
No
CT_733
3329191
hypothetical protein [Chlamydia trachoma...
448
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90313
(
show subtarget assignments
)
8
cloned
No
CT_713
3329169
ompB
Outer Membrane Protein Analog [Chlamydia...
340
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90316
(
show subtarget assignments
)
8
cloned
No
CT_743
3329202
hctA
Histone-Like Developmental Protein [Chla...
125
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90319
(
show subtarget assignments
)
8
cloned
No
CT_753
3329214
hypothetical protein [Chlamydia trachoma...
74
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90318
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_718
3329174
hypothetical protein [Chlamydia trachoma...
174
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90317
(
show subtarget assignments
)
8
cloned
No
CT_724
3329181
hypothetical protein [Chlamydia trachoma...
174
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90322
(
show subtarget assignments
)
8
expressed
No
CT_809
3329276
hypothetical protein [Chlamydia trachoma...
103
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90325
(
show subtarget assignments
)
8
cloned
No
CT089
15604808
lcrE
low calcium response E [Chlamydia tracho...
421
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2VJ4
13.3%
Chlamydia trachomatis
IDP90324
(
show subtarget assignments
)
8
expressed
No
CT088
15604807
sycE
secretion chaperone [Chlamydia trachomat...
146
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90323
(
show subtarget assignments
)
8
cloned
No
CT082
15604801
hypothetical protein CT082 [Chlamydia tr...
560
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90647
(
show subtarget assignments
)
8
cloned
No
VC2685
15642680
metF
5,10-methylenetetrahydrofolate reductase...
304
Predicted Essential
Community Requests
1ZP3
75.3%
Vibrio cholerae
IDP90646
(
show subtarget assignments
)
8
in_pdb
3NXK
No
Cj0029
15791428
ansA
L-asparaginase [Campylobacter jejuni sub...
331
Predicted Essential
Community Requests
3NXK
100%
Campylobacter jejuni
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