Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02487 (show subtarget assignments)	1	cloned	No	GBAA4218	47529511	metE	5-methyltetrahydropteroyltriglutamate--h...	762	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2NQ5	51.3%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP90865 (show subtarget assignments)	8	purified	No	VC2430	15642427		DNA topoisomerase IV subunit A [Vibrio c...	761	Predicted Essential	Community Requests	1ZVU	66.9%	Vibrio cholerae

IDP05297 (show subtarget assignments)	1	cloned	No	CD2188	126699804	mapA	maltose phosphorylase [Clostridium diffi...	761	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1H54	51.9%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01896 (show subtarget assignments)	1	soluble	No	STM0611	16763988		putative oxidoreductase protein [Salmone...	759	Conserved; Drug target functions	Phase 3: June 2008	1DMR	29.2%	Salmonella enterica	Energy metabolism	ATP-proton motive force interconversion

IDP02361 (show subtarget assignments)	1	expressed	No	CBU_1550	29542109	ptsP	phosphoenolpyruvate-protein phosphotrans...	759	Conserved; Drug target functions	Phase 3: June 2008	2HRO	28.3%	Coxiella burnetii	Signal transduction	PTS

IDP91816 (show subtarget assignments)	8	cloned	No	b2463	1788806	maeB	fused malic enzyme predicted oxidoreduct...	759	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1WW8	26.5%	Escherichia coli

IDP90866 (show subtarget assignments)	8	cloned	No	YPO0671	16120996	parC	DNA topoisomerase IV subunit A [Yersinia...	757	Predicted Essential	Community Requests	1ZVU	78.2%	Yersinia pestis

IDP01335 (show subtarget assignments)	1	soluble	No	VC1144	15641157	clpA	ATP-dependent Clp protease ATP-binding s...	756	Drug Target Function	Phase 2: March 2008	1KSF	77.9%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05654 (show subtarget assignments)	1	soluble	No	lmo0105	16802153	-	hypothetical protein lmo0105 [Listeria m...	756	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1ITX	19.4%	Listeria monocytogenes	Energy metabolism: ATP-proton motive force interconversion

IDP02258 (show subtarget assignments)	1	cloned	No	Cj0178	15791565		putative outer membrane siderophore rece...	755	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	3CSL	24.9%	Campylobacter jejuni	Cell envelope	Other

IDP00490 (show subtarget assignments)	1	cloned	No	YPO1537	16121810		putative iron-siderophore receptor	753	Conserved Gene / Pathway	Phase 2: March 2008	3EFM	36%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00344 (show subtarget assignments)	1	cloned	No	lmo2039	16804078	pbpB	hypothetical protein lmo2039	751	Drug Target Function	Phase 2: March 2008	1RP5	34.1%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90983 (show subtarget assignments)	8	selected	No	y0870	22124781	katG	catalase-peroxidase [Yersinia pestis KIM...	751	virulence/pathogenesis / stress response protein and antigen in Y pestis	Community Requests	2FXG	59.4%	Yersinia pestis

IDP91716 (show subtarget assignments)	8	selected	No	NP_009330	6274552	STAT1	signal transducer and activator of trans...	750	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1YVL	91.1%	Homo sapiens

IDP02354 (show subtarget assignments)	1	cloned	No	Cj0887c	15792217	flaD	flagellar hook-associated protein [Campy...	750	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008	1UCU	13.9%	Campylobacter jejuni	Cell envelope	Other

IDP92567 (show subtarget assignments)	8	selected	No	AEF33500	333454592		polyprotein, partial [Dengue virus 3]	749	potential drug target / Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...	Community Requests	2VBC	65.2%	Dengue virus

IDP90952 (show subtarget assignments)	8	soluble	No	UTI89_C2726	122422986		Hypothetical protein yfeA	749	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	13.4%	Escherichia coli

IDP92105 (show subtarget assignments)	8	selected	No	TGME49_043800	237835163		long-chain fatty acid CoA ligase, putati...	748	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3NYQ	17.8%	Toxoplasma gondii

IDP05182 (show subtarget assignments)	1	soluble	No	BA_4984	30259476	gerHA	spore germination protein GerHA [Bacillu...	747	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3FBY	7.5%	Bacillus anthracis	Cellular processes: Sporulation and germination

IDP90967 (show subtarget assignments)	8	cloned	No	UTI89_C2819	122422922		Hypothetical protein yfgF	747	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3HVB	14.2%	Escherichia coli

IDP04654 (show subtarget assignments)	1	purified	No	FTT1526c	56708560	idh	isocitrate dehydrogenase [Francisella tu...	747	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1ITW	62.7%	Francisella tularensis

IDP00794 (show subtarget assignments)	1	cloned	No	SACOL1194	57284479	pbp1	penicillin-binding protein 1	744	Drug Target Function	Phase 2: March 2008	1PYY	30.9%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04550 (show subtarget assignments)	1	cloned	No	CPF_0460	110798921		sensor histidine kinase [Clostridium per...	743	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	9.6%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP00050 (show subtarget assignments)	1	cloned	No	BA_3443	30257983		enhancin family protein	742	Virulence	Phase 1: October 2007			Bacillus anthracis	Cellular processes	Pathogenesis

IDP91673 (show subtarget assignments)	8	selected	No	CD44_HUMAN	0			742	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1POZ	21.4%	Homo sapiens

IDP04129 (show subtarget assignments)	1	expressed	No	YPO0764	115346558		conserved hypothetical protein [Yersinia...	741	virulence factor; putative drug target function;	Phase 4: April 2009	2P5Z	16.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP01655 (show subtarget assignments)	1	purified	No	FTT0721c	56707839	katG	peroxidase/catalase [Francisella tularen...	741	Drug Target	Phase 3: June 2008	1MWV	53.3%	Francisella tularensis	Cellular processes	Detoxification

IDP92119 (show subtarget assignments)	8	selected	No	TGME49_112520	237830353		tRNA delta(2)-isopentenylpyrophosphate t...	741	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3EPH	19.2%	Toxoplasma gondii

IDP01348 (show subtarget assignments)	0	work_stopped	No	VCA0219	15600988		haemolysin	741	Conserved Gene / Pathway	Phase 2: March 2008	1XEZ	94.7%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP91892 (show subtarget assignments)	8	selected	No	SpneCM_010100009040	298255720		DNA translocase ftsk [Streptococcus pneu...	741	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2IUT	33.5%	Streptococcus pneumoniae

IDP01906 (show subtarget assignments)	1	soluble	No	GBAA0294	47525557	purL	phosphoribosylformylglycinamidine syntha...	739	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3AC6	46.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04401 (show subtarget assignments)	1	expressed	No	VC1831	15641833		sensor histidine kinase [Vibrio cholerae...	736	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10.2%	Vibrio cholerae	Regulatory functions	Other

IDP05744 (show subtarget assignments)	1	cloned	No	CD2744	126700359	relA	putative GTP pyrophosphokinase [Clostrid...	735	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VJ7	26.4%	Clostridium difficile	Cellular processes: Adaptations to atypical conditions

IDP91552 (show subtarget assignments)	8	expressed	No	BAB38718	13364773	ECs5295	hypothetical protein [Escherichia coli O...	735	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3DU1	9.1%	Escherichia coli

IDP90937 (show subtarget assignments)	8	cloned	No	YPO0110	16120456	priA	primosome assembly protein PriA	732	Predicted Essential	Community Requests	2EYQ	9.4%	Yersinia pestis

IDP04399 (show subtarget assignments)	1	cloned	No	YPO3613	218930623		putative Rhs accessory genetic element [...	732	virulence factor; putative drug target function;	Phase 4: April 2009	2P5Z	15.8%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP90861 (show subtarget assignments)	8	selected	No	VC1036	15641049		methionyl-tRNA synthetase [Vibrio choler...	731	Predicted Essential	Community Requests	1F4L	57.7%	Vibrio cholerae

IDP05759 (show subtarget assignments)	1	cloned	No	lmo1759	16803799	pcrA	ATP-dependent DNA helicase [Listeria mon...	733	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1PJR	65.1%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP90981 (show subtarget assignments)	8	selected	No	y0850	22124761		outer membrane receptor [Yersinia pestis...	731	other biological interest / putative iron-binding TonB-dependent outer membrane receptor	Community Requests	2HDF	31.1%	Yersinia pestis

IDP00503 (show subtarget assignments)	1	purified	No	YPO3766	16123902	fadB	multifunctional fatty acid oxidation com...	729	Virulence Associated Factor	Phase 2: March 2008	1WDK	55.1%	Yersinia pestis	Cellular processes	Detoxification

IDP04081 (show subtarget assignments)	1	purified	No	BAS0361	49183389		DNA topoisomerase III [Bacillus anthraci...	729	Proposed to be essential proteins	Phase 4: April 2009	1D6M	27.7%	Bacillus anthracis

IDP00911 (show subtarget assignments)	1	expressed	No	STM0191	16763581	fhuA	ferrichrome outer membrane transporter	729	Conserved Gene / Pathway	Phase 2: March 2008	2FCP	72.3%	Salmonella enterica	Cell envelope	Other

IDP90708 (show subtarget assignments)	8	cloned	No	Cj0955c	15792284	purL	phosphoribosylformylglycinamidine syntha...	728	Predicted Essential	Community Requests	3AC6	40.2%	Campylobacter jejuni

IDP91555 (show subtarget assignments)	8	expressed	No	BAB38358	13364411	ECs4935	regulator of acetyl CoA synthetase [Esch...	728	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP02224 (show subtarget assignments)	1	cloned	No	YPO0616	16120942		putative glycosyl hydrolase [Yersinia pe...	727	Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...	Phase 3: June 2008	2X40	26.5%	Yersinia pestis	Energy metabolism	Sugars

IDP00201 (show subtarget assignments)	1	expressed	No	YPO1476	16121751	-	hypothetical protein	727	Virulence	Phase 1: October 2007			Yersinia pestis	Energy metabolism	Photosynthesis

IDP91808 (show subtarget assignments)	8	selected	No	AAB07788	924760	CTCF	CTCF [Homo sapiens]	727	innate immunity / CTCF (CCCTC-binding factor) is an evolutionarily-conserved transcription factor ...	Community Requests	1X6H	10.2%	Homo sapiens

IDP04267 (show subtarget assignments)	1	cloned	No	CPF_2134	110799922	spoVD	stage V sporulation protein D [Clostridi...	727	conserved gene; putative drug target function;	Phase 4: April 2009	1RP5	26.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP02040 (show subtarget assignments)	1	expressed	No	GBAA4637	47529935	relA	GTP pyrophosphokinase [Bacillus anthraci...	727	CONSERVED. Additional information: It is responsible for a down-regulation of RN...	Phase 3: June 2008	1VJ7	31.2%	Bacillus anthracis	Cellular processes: Adaptations to atypical conditions	N/A

IDP01075 (show subtarget assignments)	1	cloned	No	STM4106	16767372	katG	hydroperoxidase	726	Essential Gene	Phase 2: March 2008	1MWV	64.3%	Salmonella enterica	Cellular processes	Detoxification

IDP04269 (show subtarget assignments)	1	cloned	No	CPF_2193	110798612	relA	GTP pyrophosphokinase [Clostridium perfr...	726	conserved gene; putative drug target function;	Phase 4: April 2009	1VJ7	28.1%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP91362 (show subtarget assignments)	8	soluble	No	VV1_2836	27366118		peptide ABC transporter permease [Vibrio...	725	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP02671 (show subtarget assignments)	1	selected	No	lmo0997	16803037	clpE	ATP-dependent protease [Listeria monocyt...	724	Known virulence-Invasion; PMID:9987121; Presence of Protease Motifs	Phase 3: June 2008	1QVR	46.3%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP04410 (show subtarget assignments)	1	cloned	No	VC1047	9655512		fatty oxidation complex, alpha subunit [...	724	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1WDK	36.4%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Degradation

IDP02422 (show subtarget assignments)	1	cloned	No	YPO1666	16121930	cheA	chemotaxis protein CheA [Yersinia pestis...	723	Conserved; CD; Drug target functions	Phase 3: June 2008	1B3Q	22.7%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP90600 (show subtarget assignments)	8	cloned	No	VC0190	15640220	uvrD	DNA-dependent helicase II [Vibrio choler...	723	Predicted Essential	Community Requests	2IS1	66.8%	Vibrio cholerae

IDP91947 (show subtarget assignments)	8	selected	No	SpneCM_010100001889	298254350		amino acid ABC transporter, amino acid-b...	721	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3HV1	10.4%	Streptococcus pneumoniae

IDP04190 (show subtarget assignments)	1	cloned	No	CPF_0544	110800679	spoVD	stage V sporulation protein D [Clostridi...	721	conserved gene; putative drug target function;	Phase 4: April 2009	1PYY	27.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05079 (show subtarget assignments)	1	cloned	No	lmo1438	16803478	-	hypothetical protein lmo1438 [Listeria m...	721	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2WAE	32.6%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90755 (show subtarget assignments)	8	cloned	No	YPO3841	16123976	uvrD	DNA-dependent helicase II [Yersinia pest...	720	Predicted Essential	Community Requests	2IS1	83.3%	Yersinia pestis

IDP90528 (show subtarget assignments)	8	cloned	No	VCA1063	15601814		ornithine decarboxylase [Vibrio cholerae...	720	Predicted Essential	Community Requests	1ORD	59.1%	Vibrio cholerae

IDP05321 (show subtarget assignments)	1	cloned	No	CD1857	126699466		putative conjugative transposon cell wal...	720	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2K1G	5%	Clostridium difficile	Unknown function: General

IDP05263 (show subtarget assignments)	1	cloned	No	CD2793	126700409	slpA	cell surface protein (S-layer precursor ...	719	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3CVZ	36.4%	Clostridium difficile	Cell envelope: Other

IDP01364 (show subtarget assignments)	1	expressed	No	VC0200	15640230		iron(III) compound receptor	718	Conserved Gene / Pathway	Phase 2: March 2008	3QLB	33.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP05706 (show subtarget assignments)	1	purified	No	lmo2756	16804793	topB	DNA topoisomerase III [Listeria monocyto...	717	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1D6M	28.6%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP91316 (show subtarget assignments)	8	purified	No	VV2_1515	27367862		toxin secretion ATP-binding protein [Vib...	717	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3G5U	23.1%	Vibrio vulnificus

IDP02515 (show subtarget assignments)	1	cloned	No	YPO2567	16122785	pta	phosphate acetyltransferase [Yersinia pe...	717	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1TD9	20.6%	Yersinia pestis	Energy metabolism	Fermentation

IDP01249 (show subtarget assignments)	1	cloned	No	BA_4055	30258562		penicillin-binding protein	716	Drug Target Function	Phase 2: March 2008	1QME	30.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90990 (show subtarget assignments)	8	selected	No	y1223	22125125	nrdE	ribonucleotide-diphosphate reductase sub...	716	iron-regulated reductase	Community Requests	1PEM	72.6%	Yersinia pestis

IDP05304 (show subtarget assignments)	1	cloned	No	Z1313	12514147	helD	DNA helicase IV [Escherichia coli O157:H...	715	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2IS1	14.3%	Escherichia coli	DNA metabolism: DNA replication, recombination, and repair

IDP00999 (show subtarget assignments)	1	expressed	No	STM2388	16765715	fadJ	multifunctional fatty acid oxidation com...	715	Conserved Gene / Pathway	Phase 2: March 2008	1WDK	35.8%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP01923 (show subtarget assignments)	1	crystallized	No	STM1595	16764939	srfC	putative virulence protein [Salmonella t...	714	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unclassified	Role category not yet assigned

IDP00358 (show subtarget assignments)	1	cloned	No	lmo2229	16804268		hypothetical protein lmo2229	714	Possible Vaccine Candidate; Presence of Protease Motifs; Drug Target Homologs	Phase 2: March 2008	3UDF	29.7%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01479 (show subtarget assignments)	1	expressed	No	VCA0064	15600835		TonB system receptor, putative	713	Conserved Gene / Pathway	Phase 2: March 2008	1NQF	22.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP05189 (show subtarget assignments)	1	cloned	No	CD0240	126697811		putative glycosyltransferase [Clostridiu...	713	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Protein fate: Protein modification and repair

IDP01246 (show subtarget assignments)	1	cloned	No	BA_2648	30257265		penicillin-binding protein	712	Drug Target Function	Phase 2: March 2008	1QME	29.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00214 (show subtarget assignments)	1	expressed	No	YPO2252	16122476	-	putative toxin transport protein	712	Virulence	Phase 1: October 2007	2YL4	26.1%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP02400 (show subtarget assignments)	1	purified	No	YPO3454	16123600	nrdD	anaerobic ribonucleoside triphosphate re...	712	Conserved; CD; Drug target functions	Phase 3: June 2008	1H78	48.2%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP91046 (show subtarget assignments)	8	in_pdb 4ECL	No	EFE0004	33355854	vanTG	serine racemase [Enterococcus faecalis]	712	drug resistance / Putative serine racemase involved in synthesis of D-Ala-D-Ser, a component of va...	Community Requests	4ECL	52.5%	Enterococcus faecalis

IDP92033 (show subtarget assignments)	8	selected	No	TGME49_019850	237842879		prolyl-tRNA synthetase, putative [Toxopl...	711	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1H4Q	30.2%	Toxoplasma gondii

IDP91707 (show subtarget assignments)	8	selected	No	NP_005447	4885433	MAPK8IP1	C-Jun-amino-terminal kinase-interacting ...	711	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2FPF	9.8%	Homo sapiens

IDP01045 (show subtarget assignments)	1	soluble	No	STM3114	16766415	speC	ornithine decarboxylase isozyme	711	Conserved Gene / Pathway	Phase 2: March 2008	1ORD	53.8%	Salmonella enterica	Central intermediary metabolism	Polyamine biosynthesis

IDP02626 (show subtarget assignments)	1	cloned	No	Cj1614	15792919	chuA	TonB-dependent heme receptor [Campylobac...	709	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	3FHH	23.3%	Campylobacter jejuni	Regulatory functions	Other

IDP05198 (show subtarget assignments)	1	cloned	No	CD1433	126699037		putative bifunctional protein: peroxired...	709	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1ITX	17.3%	Clostridium difficile	Cellular processes: Detoxification

IDP05070 (show subtarget assignments)	1	cloned	No	CD3246	126700865		putative surface protein [Clostridium di...	709	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Surface structures

IDP91314 (show subtarget assignments)	8	cloned	No	VP1662	28898436		low calcium response protein [Vibrio par...	708	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2X49	16.2%	Vibrio parahaemolyticus

IDP01245 (show subtarget assignments)	1	cloned	No	BA_2637	30257254		penicillin-binding protein	708	Drug Target Function	Phase 2: March 2008	2WAD	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01729 (show subtarget assignments)	1	cloned	No	FTT0808	56707919	spoT	guanosine-3',5'-bis(diphosphate) 3'-pyro...	707	Conserved; Drug target functions	Phase 3: June 2008	1VJ7	23.6%	Francisella tularensis	Regulatory functionsAmino acid biosynthesis	OtherHistidine family

IDP02408 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1418	16121698		23S rRNA m(2)G2445 methyltransferase [Ye...	706	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3V8V	74.8%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP01250 (show subtarget assignments)	1	cloned	No	BA_4497	30259003		penicillin-binding protein	706	Drug Target Function	Phase 2: March 2008	2WAF	33%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01240 (show subtarget assignments)	1	cloned	No	BA_1069	30254800	pbpF	penicillin-binding protein 1	705	Drug Target Function	Phase 2: March 2008	2OLU	27.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91636 (show subtarget assignments)	8	cloned	No	NP_217464	15610085		acyl-CoA synthetase [Mycobacterium tuber...	705	virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...	Community Requests	2V7B	23%	Mycobacterium tuberculosis

IDP05118 (show subtarget assignments)	1	cloned	No	Z5902	12519310		putative helicase [Escherichia coli O157...	704	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1PJR	12.8%	Escherichia coli	Protein synthesis: Ribosomal proteins: synthesis and modification

IDP05640 (show subtarget assignments)	1	cloned	No	CD2767	126700383		cell surface protein [Clostridium diffic...	703	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP92560 (show subtarget assignments)	8	selected	No	1PYY_A	37927671		Chain A, Double Mutant Pbp2x T338aM339F ...	702	potential drug target / Pptase, FactorXa, HCV NS3/NS4A, Trypsin and Elastase/Subtilisin (see below)] and...	Community Requests	1PYY	100%	Streptococcus pneumoniae

IDP00697 (show subtarget assignments)	1	purified	No	SACOL2563	57285245		ATP-dependent Clp protease, putative	701	Drug Target Function	Phase 2: March 2008	1QVR	43.1%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90582 (show subtarget assignments)	8	soluble	No	Cj1686c	15792989	topA	DNA topoisomerase I [Campylobacter jejun...	700	Predicted Essential	Community Requests	2GAI	38.6%	Campylobacter jejuni

IDP01848 (show subtarget assignments)	1	cloned	No	FTT1754	56708752	pta	phosphate acetyltransferase [Francisella...	698	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1TD9	19.9%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP91048 (show subtarget assignments)	8	in_crystallization_trials	No	EGA0001	4545123	vanT	serine racemase VanT [Enterococcus galli...	698	drug resistance / Serine racemase involved in synthesis of D-Ala-D-Ser, a component of vancomycin ...	Community Requests	4ECL	22.3%	Enterococcus gallinarum

IDP90326 (show subtarget assignments)	8	expressed	No	CT_351	3328772		hypothetical protein [Chlamydia trachoma...	697	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02487
(show subtarget assignments)

1

cloned

No

GBAA4218

47529511

metE

5-methyltetrahydropteroyltriglutamate--h...

762

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2NQ5

51.3%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP90865
(show subtarget assignments)

8

purified

No

VC2430

15642427

DNA topoisomerase IV subunit A [Vibrio c...

761

Predicted Essential

Community Requests

1ZVU

66.9%

Vibrio cholerae

IDP05297
(show subtarget assignments)

1

cloned

No

CD2188

126699804

mapA

maltose phosphorylase [Clostridium diffi...

761

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1H54

51.9%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01896
(show subtarget assignments)

1

soluble

No

STM0611

16763988

putative oxidoreductase protein [Salmone...

759

Conserved; Drug target functions

Phase 3: June 2008

1DMR

29.2%

Salmonella enterica

Energy metabolism

ATP-proton motive force interconversion

IDP02361
(show subtarget assignments)

1

expressed

No

CBU_1550

29542109

ptsP

phosphoenolpyruvate-protein phosphotrans...

759

Conserved; Drug target functions

Phase 3: June 2008

2HRO

28.3%

Coxiella burnetii

Signal transduction

PTS

IDP91816
(show subtarget assignments)

8

cloned

No

b2463

1788806

maeB

fused malic enzyme predicted oxidoreduct...

759

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1WW8

26.5%

Escherichia coli

IDP90866
(show subtarget assignments)

8

cloned

No

YPO0671

16120996

parC

DNA topoisomerase IV subunit A [Yersinia...

757

Predicted Essential

Community Requests

1ZVU

78.2%

Yersinia pestis

IDP01335
(show subtarget assignments)

1

soluble

No

VC1144

15641157

clpA

ATP-dependent Clp protease ATP-binding s...

756

Drug Target Function

Phase 2: March 2008

1KSF

77.9%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05654
(show subtarget assignments)

1

soluble

No

lmo0105

16802153

-

hypothetical protein lmo0105 [Listeria m...

756

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1ITX

19.4%

Listeria monocytogenes

Energy metabolism: ATP-proton motive force interconversion

IDP02258
(show subtarget assignments)

1

cloned

No

Cj0178

15791565

putative outer membrane siderophore rece...

755

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

3CSL

24.9%

Campylobacter jejuni

Cell envelope

Other

IDP00490
(show subtarget assignments)

1

cloned

No

YPO1537

16121810

putative iron-siderophore receptor

753

Conserved Gene / Pathway

Phase 2: March 2008

3EFM

36%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00344
(show subtarget assignments)

1

cloned

No

lmo2039

16804078

pbpB

hypothetical protein lmo2039

751

Drug Target Function

Phase 2: March 2008

1RP5

34.1%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90983
(show subtarget assignments)

8

selected

No

y0870

22124781

katG

catalase-peroxidase [Yersinia pestis KIM...

751

virulence/pathogenesis / stress response protein and antigen in Y pestis

Community Requests

2FXG

59.4%

Yersinia pestis

IDP91716
(show subtarget assignments)

8

selected

No

NP_009330

6274552

STAT1

signal transducer and activator of trans...

750

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1YVL

91.1%

Homo sapiens

IDP02354
(show subtarget assignments)

1

cloned

No

Cj0887c

15792217

flaD

flagellar hook-associated protein [Campy...

750

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

1UCU

13.9%

Campylobacter jejuni

Cell envelope

Other

IDP92567
(show subtarget assignments)

8

selected

No

AEF33500

333454592

polyprotein, partial [Dengue virus 3]

749

potential drug target / Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...

Community Requests

2VBC

65.2%

Dengue virus

IDP90952
(show subtarget assignments)

8

soluble

No

UTI89_C2726

122422986

Hypothetical protein yfeA

749

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

13.4%

Escherichia coli

IDP92105
(show subtarget assignments)

8

selected

No

TGME49_043800

237835163

long-chain fatty acid CoA ligase, putati...

748

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3NYQ

17.8%

Toxoplasma gondii

IDP05182
(show subtarget assignments)

1

soluble

No

BA_4984

30259476

gerHA

spore germination protein GerHA [Bacillu...

747

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3FBY

7.5%

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP90967
(show subtarget assignments)

8

cloned

No

UTI89_C2819

122422922

Hypothetical protein yfgF

747

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3HVB

14.2%

Escherichia coli

IDP04654
(show subtarget assignments)

1

purified

No

FTT1526c

56708560

idh

isocitrate dehydrogenase [Francisella tu...

747

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1ITW

62.7%

Francisella tularensis

IDP00794
(show subtarget assignments)

1

cloned

No

SACOL1194

57284479

pbp1

penicillin-binding protein 1

744

Drug Target Function

Phase 2: March 2008

1PYY

30.9%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04550
(show subtarget assignments)

1

cloned

No

CPF_0460

110798921

sensor histidine kinase [Clostridium per...

743

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

9.6%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP00050
(show subtarget assignments)

1

cloned

No

BA_3443

30257983

enhancin family protein

742

Virulence

Phase 1: October 2007

Bacillus anthracis

Cellular processes

Pathogenesis

IDP91673
(show subtarget assignments)

8

selected

No

CD44_HUMAN

0

742

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1POZ

21.4%

Homo sapiens

IDP04129
(show subtarget assignments)

1

expressed

No

YPO0764

115346558

conserved hypothetical protein [Yersinia...

741

virulence factor; putative drug target function;

Phase 4: April 2009

2P5Z

16.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP01655
(show subtarget assignments)

1

purified

No

FTT0721c

56707839

katG

peroxidase/catalase [Francisella tularen...

741

Drug Target

Phase 3: June 2008

1MWV

53.3%

Francisella tularensis

Cellular processes

Detoxification

IDP92119
(show subtarget assignments)

8

selected

No

TGME49_112520

237830353

tRNA delta(2)-isopentenylpyrophosphate t...

741

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3EPH

19.2%

Toxoplasma gondii

IDP01348
(show subtarget assignments)

0

work_stopped

No

VCA0219

15600988

haemolysin

741

Conserved Gene / Pathway

Phase 2: March 2008

1XEZ

94.7%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP91892
(show subtarget assignments)

8

selected

No

SpneCM_010100009040

298255720

DNA translocase ftsk [Streptococcus pneu...

741

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2IUT

33.5%

Streptococcus pneumoniae

IDP01906
(show subtarget assignments)

1

soluble

No

GBAA0294

47525557

purL

phosphoribosylformylglycinamidine syntha...

739

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3AC6

46.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04401
(show subtarget assignments)

1

expressed

No

VC1831

15641833

sensor histidine kinase [Vibrio cholerae...

736

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10.2%

Vibrio cholerae

Regulatory functions

Other

IDP05744
(show subtarget assignments)

1

cloned

No

CD2744

126700359

relA

putative GTP pyrophosphokinase [Clostrid...

735

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VJ7

26.4%

Clostridium difficile

Cellular processes: Adaptations to atypical conditions

IDP91552
(show subtarget assignments)

8

expressed

No

BAB38718

13364773

ECs5295

hypothetical protein [Escherichia coli O...

735

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3DU1

9.1%

Escherichia coli

IDP90937
(show subtarget assignments)

8

cloned

No

YPO0110

16120456

priA

primosome assembly protein PriA

732

Predicted Essential

Community Requests

2EYQ

9.4%

Yersinia pestis

IDP04399
(show subtarget assignments)

1

cloned

No

YPO3613

218930623

putative Rhs accessory genetic element [...

732

virulence factor; putative drug target function;

Phase 4: April 2009

2P5Z

15.8%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP90861
(show subtarget assignments)

8

selected

No

VC1036

15641049

methionyl-tRNA synthetase [Vibrio choler...

731

Predicted Essential

Community Requests

1F4L

57.7%

Vibrio cholerae

IDP05759
(show subtarget assignments)

1

cloned

No

lmo1759

16803799

pcrA

ATP-dependent DNA helicase [Listeria mon...

733

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1PJR

65.1%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP90981
(show subtarget assignments)

8

selected

No

y0850

22124761

outer membrane receptor [Yersinia pestis...

731

other biological interest / putative iron-binding TonB-dependent outer membrane receptor

Community Requests

2HDF

31.1%

Yersinia pestis

IDP00503
(show subtarget assignments)

1

purified

No

YPO3766

16123902

fadB

multifunctional fatty acid oxidation com...

729

Virulence Associated Factor

Phase 2: March 2008

1WDK

55.1%

Yersinia pestis

Cellular processes

Detoxification

IDP04081
(show subtarget assignments)

1

purified

No

BAS0361

49183389

DNA topoisomerase III [Bacillus anthraci...

729

Proposed to be essential proteins

Phase 4: April 2009

1D6M

27.7%

Bacillus anthracis

IDP00911
(show subtarget assignments)

1

expressed

No

STM0191

16763581

fhuA

ferrichrome outer membrane transporter

729

Conserved Gene / Pathway

Phase 2: March 2008

2FCP

72.3%

Salmonella enterica

Cell envelope

Other

IDP90708
(show subtarget assignments)

8

cloned

No

Cj0955c

15792284

purL

phosphoribosylformylglycinamidine syntha...

728

Predicted Essential

Community Requests

3AC6

40.2%

Campylobacter jejuni

IDP91555
(show subtarget assignments)

8

expressed

No

BAB38358

13364411

ECs4935

regulator of acetyl CoA synthetase [Esch...

728

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP02224
(show subtarget assignments)

1

cloned

No

YPO0616

16120942

putative glycosyl hydrolase [Yersinia pe...

727

Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...

Phase 3: June 2008

2X40

26.5%

Yersinia pestis

Energy metabolism

Sugars

IDP00201
(show subtarget assignments)

1

expressed

No

YPO1476

16121751

-

hypothetical protein

727

Virulence

Phase 1: October 2007

Yersinia pestis

Energy metabolism

Photosynthesis

IDP91808
(show subtarget assignments)

8

selected

No

AAB07788

924760

CTCF

CTCF [Homo sapiens]

727

innate immunity / CTCF (CCCTC-binding factor) is an evolutionarily-conserved transcription factor ...

Community Requests

1X6H

10.2%

Homo sapiens

IDP04267
(show subtarget assignments)

1

cloned

No

CPF_2134

110799922

spoVD

stage V sporulation protein D [Clostridi...

727

conserved gene; putative drug target function;

Phase 4: April 2009

1RP5

26.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP02040
(show subtarget assignments)

1

expressed

No

GBAA4637

47529935

relA

GTP pyrophosphokinase [Bacillus anthraci...

727

CONSERVED. Additional information: It is responsible for a down-regulation of RN...

Phase 3: June 2008

1VJ7

31.2%

Bacillus anthracis

Cellular processes: Adaptations to atypical conditions

N/A

IDP01075
(show subtarget assignments)

1

cloned

No

STM4106

16767372

katG

hydroperoxidase

726

Essential Gene

Phase 2: March 2008

1MWV

64.3%

Salmonella enterica

Cellular processes

Detoxification

IDP04269
(show subtarget assignments)

1

cloned

No

CPF_2193

110798612

relA

GTP pyrophosphokinase [Clostridium perfr...

726

conserved gene; putative drug target function;

Phase 4: April 2009

1VJ7

28.1%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP91362
(show subtarget assignments)

8

soluble

No

VV1_2836

27366118

peptide ABC transporter permease [Vibrio...

725

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP02671
(show subtarget assignments)

1

selected

No

lmo0997

16803037

clpE

ATP-dependent protease [Listeria monocyt...

724

Known virulence-Invasion; PMID:9987121; Presence of Protease Motifs

Phase 3: June 2008

1QVR

46.3%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP04410
(show subtarget assignments)

1

cloned

No

VC1047

9655512

fatty oxidation complex, alpha subunit [...

724

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1WDK

36.4%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Degradation

IDP02422
(show subtarget assignments)

1

cloned

No

YPO1666

16121930

cheA

chemotaxis protein CheA [Yersinia pestis...

723

Conserved; CD; Drug target functions

Phase 3: June 2008

1B3Q

22.7%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP90600
(show subtarget assignments)

8

cloned

No

VC0190

15640220

uvrD

DNA-dependent helicase II [Vibrio choler...

723

Predicted Essential

Community Requests

2IS1

66.8%

Vibrio cholerae

IDP91947
(show subtarget assignments)

8

selected

No

SpneCM_010100001889

298254350

amino acid ABC transporter, amino acid-b...

721

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3HV1

10.4%

Streptococcus pneumoniae

IDP04190
(show subtarget assignments)

1

cloned

No

CPF_0544

110800679

spoVD

stage V sporulation protein D [Clostridi...

721

conserved gene; putative drug target function;

Phase 4: April 2009

1PYY

27.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP05079
(show subtarget assignments)

1

cloned

No

lmo1438

16803478

-

hypothetical protein lmo1438 [Listeria m...

721

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2WAE

32.6%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90755
(show subtarget assignments)

8

cloned

No

YPO3841

16123976

uvrD

DNA-dependent helicase II [Yersinia pest...

720

Predicted Essential

Community Requests

2IS1

83.3%

Yersinia pestis

IDP90528
(show subtarget assignments)

8

cloned

No

VCA1063

15601814

ornithine decarboxylase [Vibrio cholerae...

720

Predicted Essential

Community Requests

1ORD

59.1%

Vibrio cholerae

IDP05321
(show subtarget assignments)

1

cloned

No

CD1857

126699466

putative conjugative transposon cell wal...

720

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2K1G

5%

Clostridium difficile

Unknown function: General

IDP05263
(show subtarget assignments)

1

cloned

No

CD2793

126700409

slpA

cell surface protein (S-layer precursor ...

719

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3CVZ

36.4%

Clostridium difficile

Cell envelope: Other

IDP01364
(show subtarget assignments)

1

expressed

No

VC0200

15640230

iron(III) compound receptor

718

Conserved Gene / Pathway

Phase 2: March 2008

3QLB

33.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP05706
(show subtarget assignments)

1

purified

No

lmo2756

16804793

topB

DNA topoisomerase III [Listeria monocyto...

717

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1D6M

28.6%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP91316
(show subtarget assignments)

8

purified

No

VV2_1515

27367862

toxin secretion ATP-binding protein [Vib...

717

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3G5U

23.1%

Vibrio vulnificus

IDP02515
(show subtarget assignments)

1

cloned

No

YPO2567

16122785

pta

phosphate acetyltransferase [Yersinia pe...

717

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1TD9

20.6%

Yersinia pestis

Energy metabolism

Fermentation

IDP01249
(show subtarget assignments)

1

cloned

No

BA_4055

30258562

penicillin-binding protein

716

Drug Target Function

Phase 2: March 2008

1QME

30.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90990
(show subtarget assignments)

8

selected

No

y1223

22125125

nrdE

ribonucleotide-diphosphate reductase sub...

716

iron-regulated reductase

Community Requests

1PEM

72.6%

Yersinia pestis

IDP05304
(show subtarget assignments)

1

cloned

No

Z1313

12514147

helD

DNA helicase IV [Escherichia coli O157:H...

715

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2IS1

14.3%

Escherichia coli

DNA metabolism: DNA replication, recombination, and repair

IDP00999
(show subtarget assignments)

1

expressed

No

STM2388

16765715

fadJ

multifunctional fatty acid oxidation com...

715

Conserved Gene / Pathway

Phase 2: March 2008

1WDK

35.8%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP01923
(show subtarget assignments)

1

crystallized

No

STM1595

16764939

srfC

putative virulence protein [Salmonella t...

714

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00358
(show subtarget assignments)

1

cloned

No

lmo2229

16804268

hypothetical protein lmo2229

714

Possible Vaccine Candidate; Presence of Protease Motifs; Drug Target Homologs

Phase 2: March 2008

3UDF

29.7%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01479
(show subtarget assignments)

1

expressed

No

VCA0064

15600835

TonB system receptor, putative

713

Conserved Gene / Pathway

Phase 2: March 2008

1NQF

22.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP05189
(show subtarget assignments)

1

cloned

No

CD0240

126697811

putative glycosyltransferase [Clostridiu...

713

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Protein fate: Protein modification and repair

IDP01246
(show subtarget assignments)

1

cloned

No

BA_2648

30257265

penicillin-binding protein

712

Drug Target Function

Phase 2: March 2008

1QME

29.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00214
(show subtarget assignments)

1

expressed

No

YPO2252

16122476

-

putative toxin transport protein

712

Virulence

Phase 1: October 2007

2YL4

26.1%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP02400
(show subtarget assignments)

1

purified

No

YPO3454

16123600

nrdD

anaerobic ribonucleoside triphosphate re...

712

Conserved; CD; Drug target functions

Phase 3: June 2008

1H78

48.2%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP91046
(show subtarget assignments)

8

in_pdb
4ECL

No

EFE0004

33355854

vanTG

serine racemase [Enterococcus faecalis]

712

drug resistance / Putative serine racemase involved in synthesis of D-Ala-D-Ser, a component of va...

Community Requests

4ECL

52.5%

Enterococcus faecalis

IDP92033
(show subtarget assignments)

8

selected

No

TGME49_019850

237842879

prolyl-tRNA synthetase, putative [Toxopl...

711

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1H4Q

30.2%

Toxoplasma gondii

IDP91707
(show subtarget assignments)

8

selected

No

NP_005447

4885433

MAPK8IP1

C-Jun-amino-terminal kinase-interacting ...

711

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2FPF

9.8%

Homo sapiens

IDP01045
(show subtarget assignments)

1

soluble

No

STM3114

16766415

speC

ornithine decarboxylase isozyme

711

Conserved Gene / Pathway

Phase 2: March 2008

1ORD

53.8%

Salmonella enterica

Central intermediary metabolism

Polyamine biosynthesis

IDP02626
(show subtarget assignments)

1

cloned

No

Cj1614

15792919

chuA

TonB-dependent heme receptor [Campylobac...

709

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

3FHH

23.3%

Campylobacter jejuni

Regulatory functions

Other

IDP05198
(show subtarget assignments)

1

cloned

No

CD1433

126699037

putative bifunctional protein: peroxired...

709

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1ITX

17.3%

Clostridium difficile

Cellular processes: Detoxification

IDP05070
(show subtarget assignments)

1

cloned

No

CD3246

126700865

putative surface protein [Clostridium di...

709

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Surface structures

IDP91314
(show subtarget assignments)

8

cloned

No

VP1662

28898436

low calcium response protein [Vibrio par...

708

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2X49

16.2%

Vibrio parahaemolyticus

IDP01245
(show subtarget assignments)

1

cloned

No

BA_2637

30257254

penicillin-binding protein

708

Drug Target Function

Phase 2: March 2008

2WAD

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01729
(show subtarget assignments)

1

cloned

No

FTT0808

56707919

spoT

guanosine-3',5'-bis(diphosphate) 3'-pyro...

707

Conserved; Drug target functions

Phase 3: June 2008

1VJ7

23.6%

Francisella tularensis

Regulatory functionsAmino acid biosynthesis

OtherHistidine family

IDP02408
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1418

16121698

23S rRNA m(2)G2445 methyltransferase [Ye...

706

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3V8V

74.8%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP01250
(show subtarget assignments)

1

cloned

No

BA_4497

30259003

penicillin-binding protein

706

Drug Target Function

Phase 2: March 2008

2WAF

33%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01240
(show subtarget assignments)

1

cloned

No

BA_1069

30254800

pbpF

penicillin-binding protein 1

705

Drug Target Function

Phase 2: March 2008

2OLU

27.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91636
(show subtarget assignments)

8

cloned

No

NP_217464

15610085

acyl-CoA synthetase [Mycobacterium tuber...

705

virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...

Community Requests

2V7B

23%

Mycobacterium tuberculosis

IDP05118
(show subtarget assignments)

1

cloned

No

Z5902

12519310

putative helicase [Escherichia coli O157...

704

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1PJR

12.8%

Escherichia coli

Protein synthesis: Ribosomal proteins: synthesis and modification

IDP05640
(show subtarget assignments)

1

cloned

No

CD2767

126700383

cell surface protein [Clostridium diffic...

703

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP92560
(show subtarget assignments)

8

selected

No

1PYY_A

37927671

Chain A, Double Mutant Pbp2x T338aM339F ...

702

potential drug target / Pptase, FactorXa, HCV NS3/NS4A, Trypsin and Elastase/Subtilisin (see below)] and...

Community Requests

1PYY

100%

Streptococcus pneumoniae

IDP00697
(show subtarget assignments)

1

purified

No

SACOL2563

57285245

ATP-dependent Clp protease, putative

701

Drug Target Function

Phase 2: March 2008

1QVR

43.1%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90582
(show subtarget assignments)

8

soluble

No

Cj1686c

15792989

topA

DNA topoisomerase I [Campylobacter jejun...

700

Predicted Essential

Community Requests

2GAI

38.6%

Campylobacter jejuni

IDP01848
(show subtarget assignments)

1

cloned

No

FTT1754

56708752

pta

phosphate acetyltransferase [Francisella...

698

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1TD9

19.9%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP91048
(show subtarget assignments)

8

in_crystallization_trials

No

EGA0001

4545123

vanT

serine racemase VanT [Enterococcus galli...

698

drug resistance / Serine racemase involved in synthesis of D-Ala-D-Ser, a component of vancomycin ...

Community Requests

4ECL

22.3%

Enterococcus gallinarum

IDP90326
(show subtarget assignments)

8

expressed

No

CT_351

3328772

hypothetical protein [Chlamydia trachoma...

697

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis