Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05031 (show subtarget assignments)	1	soluble	No	BA_0908	30254654		oligopeptide ABC transporter, oligopepti...	528	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XOC	30.7%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP04422 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4023	47529316	pyrD	dihydroorotate dehydrogenase 1B [Bacillu...	309	putative drug target function;	Phase 4: April 2009	1EP1	68%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02277 (show subtarget assignments)	1	crystallized	No	GBAA1434	47526709		glycerate dehydrogenase [Bacillus anthra...	323	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2DBQ	48.6%	Bacillus anthracis	Central intermediary metabolism	Other

IDP02273 (show subtarget assignments)	1	expressed	No	GBAA3714	47528998		hypothetical protein GBAA3714 [Bacillus ...	315	Conserved; Essential;	Phase 3: June 2008	3CCF	14.3%	Bacillus anthracis	Hypothetical proteins	Domain

IDP02603 (show subtarget assignments)	1	expressed	No	GBAA4274	47529567	nagA	N-acetylglucosamine-6-phosphate deacetyl...	380	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2VHL	44%	Bacillus anthracis	Central intermediary metabolism	Amino sugars

IDP04423 (show subtarget assignments)	1	in_pdb 3M3H 3OSC	Yes	GBAA4021	47529314	pyrE	orotate phosphoribosyltransferase [Bacil...	210	conserved gene; putative drug target function;	Phase 4: April 2009	3M3H	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02328 (show subtarget assignments)	1	expressed	No	GBAA2548	47527837		acetyl-CoA carboxylase biotin carboxylas...	445	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3N6R	51.9%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02300 (show subtarget assignments)	1	soluble	No	GBAA1860	47527151		alpha/beta fold family hydrolase [Bacill...	307	Drug target motif; Involved in sporulation;	Phase 3: June 2008	3HJU	26.7%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02272 (show subtarget assignments)	1	cloned	No	GBAA2183	47527475		neutral metalloprotease, putative [Bacil...	503	Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...	Phase 3: June 2008	1BQB	14.3%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02005 (show subtarget assignments)	1	cloned	No	GBAA0543	47525816		penicillin-binding domain-containing pro...	258	Drug target homolog; Involved in sporulation;	Phase 3: June 2008	2OQO	36%	Bacillus anthracis	Unknown function	General

IDP02609 (show subtarget assignments)	1	in_pdb 3LQN	Yes	GBAA4196	47529491		CBS domain-containing protein [Bacillus ...	147	Drug target motif;	Phase 3: June 2008	3LQN	100%	Bacillus anthracis	Unknown function	General

IDP02325 (show subtarget assignments)	1	in_pdb 3IMF	No	GBAA4204	47778260		short chain dehydrogenase [Bacillus anth...	254	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3IMF	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02601 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2462	47527752		PTS system, cellobiose-specific IIB comp...	101	Conserved; Essential; Drug target functions	Phase 3: June 2008	2L2Q	29.7%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04421 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4022	47529315	pyrF	orotidine 5'-phosphate decarboxylase [Ba...	238	putative drug target function;	Phase 4: April 2009	1DBT	61.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04424 (show subtarget assignments)	1	purified	No	GBAA4024	47529317	pyrK	dihydroorotate dehydrogenase electron tr...	259	putative drug target function;	Phase 4: April 2009	1EP3	48.6%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02318 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1251	47526517	trpC	indole-3-glycerol-phosphate synthase [Ba...	253	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3TSM	40.7%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02592 (show subtarget assignments)	1	expressed	No	GBAA1308	47526573		glycolate oxidase, iron-sulfur subunit, ...	442	Conserved; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Energy metabolism	Other

IDP04419 (show subtarget assignments)	1	soluble	No	GBAA2861	47528156		sensor histidine kinase SrrB, putative [...	458	putative drug target function;	Phase 4: April 2009	2C2A	18.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02319 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1169	47526434	prsA	peptidylprolyl isomerase [Bacillus anthr...	285	Drug target motif; Drug target functions	Phase 3: June 2008	3RFW	29.5%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP02596 (show subtarget assignments)	1	cloned	No	GBAA1269	47526536	odhB	dihydrolipoamide acetyltransferase [Baci...	418	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	38.1%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP04425 (show subtarget assignments)	1	cloned	No	GBAA4025	47529318	carB	carbamoyl phosphate synthase large subun...	1072	conserved gene; putative drug target function;	Phase 4: April 2009	1BXR	49.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02329 (show subtarget assignments)	1	in_pdb 3KQF	Yes	GBAA2551	47527840		enoyl-CoA hydratase [Bacillus anthracis ...	262	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3KQF	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP02093 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1970	47527265	thrB	homoserine kinase [Bacillus anthracis st...	297	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HUL	46.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP04397 (show subtarget assignments)	1	expressed	No	GBAA3230	47528520		sensor histidine kinase [Bacillus anthra...	457	putative drug target function;	Phase 4: April 2009	2C2A	17.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02314 (show subtarget assignments)	1	cloned	No	GBAA0599	47525877		neutral protease [Bacillus anthracis str...	566	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1NPC	53%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02320 (show subtarget assignments)	1	purified	No	GBAA1254	47526520	trpA	tryptophan synthase subunit alpha [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1UJP	39.1%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP04420 (show subtarget assignments)	1	cloned	No	GBAA3308	47528594	sdhB-1	l-serine dehydratase, iron-sulfur-depend...	232	virulence factor; putative drug target function;	Phase 4: April 2009	2IQQ	15.5%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP04689 (show subtarget assignments)	1	in_pdb 3PEA	Yes	GBAA4761	47530060		enoyl-CoA hydratase [Bacillus anthracis ...	258	conserved gene; putative drug target function;	Phase 4: April 2009	3PEA	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP04690 (show subtarget assignments)	1	expressed	No	GBAA5029	47530328		sensor histidine kinase [Bacillus anthra...	418	putative drug target function;	Phase 4: April 2009	3D36	17.7%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04369 (show subtarget assignments)	1	expressed	No	GBAA1792	47527081		sensor histidine kinase, putative [Bacil...	368	putative drug target function;	Phase 4: April 2009	3GIG	17.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02267 (show subtarget assignments)	1	soluble	No	GBAA0987	47526266		hypothetical protein GBAA0987 [Bacillus ...	66	Conserved;	Phase 3: June 2008			Bacillus anthracis	Hypothetical proteins	Conserved

IDP04685 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3438	47528724		alcohol dehydrogenase, zinc-containing [...	335	virulence factor; putative drug target function;	Phase 4: April 2009	3GAZ	37.3%	Bacillus anthracis	Energy metabolism	Fermentation

IDP04352 (show subtarget assignments)	1	soluble	No	GBAA0584	47525859		sensor histidine kinase [Bacillus anthra...	487	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	17%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02583 (show subtarget assignments)	1	soluble	No	GBAA5249	47530554		3-hydroxyacyl-CoA dehydrogenase/enoyl-Co...	793	Conserved; Drug target functions	Phase 3: June 2008	1WDK	14.6%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP04370 (show subtarget assignments)	1	cloned	No	GBAA4766	47530065		iron compound ABC transporter, iron comp...	324	virulence factor; putative drug target function;	Phase 4: April 2009	3EIW	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP04686 (show subtarget assignments)	1	expressed	No	GBAA4223	47529516	kinB-3	sporulation kinase B [Bacillus anthracis...	424	putative drug target function;	Phase 4: April 2009	3D36	22.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02280 (show subtarget assignments)	1	in_pdb 3L44	Yes	GBAA0531	47525801	hemL-1	glutamate-1-semialdehyde aminotransferas...	434	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3L44	99.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02315 (show subtarget assignments)	1	cloned	No	GBAA1132	47526402	aceA	isocitrate lyase [Bacillus anthracis str...	425	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I4E	71.4%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP04371 (show subtarget assignments)	1	expressed	No	GBAA4776	47778322		sensor histidine kinase [Bacillus anthra...	311	putative drug target function;	Phase 4: April 2009	2C2A	19.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02330 (show subtarget assignments)	1	cloned	No	GBAA1419	47526691	ilvC-1	ketol-acid reductoisomerase [Bacillus an...	336	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1NP3	55.7%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP04342 (show subtarget assignments)	1	cloned	No	GBAA1564	47526837	panD	aspartate alpha-decarboxylase [Bacillus ...	127	conserved gene; putative drug target function;	Phase 4: April 2009	2C45	52.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04683 (show subtarget assignments)	1	expressed	No	GBAA3269	47528557		iron-sulfur cluster-binding protein [Bac...	470	virulence factor; putative drug target function;	Phase 4: April 2009			Bacillus anthracis	Energy metabolism	Electron transport

IDP04687 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4340	47529637	bioD	dithiobiotin synthetase [Bacillus anthra...	242	putative drug target function;	Phase 4: April 2009	1A82	26.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04679 (show subtarget assignments)	1	expressed	No	GBAA2644	47527936	kinB-2	sporulation kinase B [Bacillus anthracis...	422	putative drug target function;	Phase 4: April 2009	3D36	27.7%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02263 (show subtarget assignments)	1	in_pdb 3U7I	Yes	GBAA0966	47526249		hypothetical protein GBAA0966 [Bacillus ...	220	Conserved; Essential;	Phase 3: June 2008	3U7I	100%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP04680 (show subtarget assignments)	1	expressed	No	GBAA3066	47528358		sensor histidine kinase, putative [Bacil...	333	putative drug target function;	Phase 4: April 2009			Bacillus anthracis	Regulatory functions	Protein interactions

IDP02298 (show subtarget assignments)	1	soluble	No	GBAA0555	47525828		collagenase,putative [Bacillus anthracis...	965	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	2Y3U	39.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04426 (show subtarget assignments)	1	expressed	No	GBAA4339	47529636	bioF	8-amino-7-oxononanoate synthase [Bacillu...	395	putative drug target function;	Phase 4: April 2009	3A2B	33.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04681 (show subtarget assignments)	1	soluble	No	GBAA3131	47528422	adhB	alcohol dehydrogenase, zinc-containing [...	377	virulence factor; putative drug target function;	Phase 4: April 2009	1KOL	31.9%	Bacillus anthracis	Energy metabolism	Fermentation

IDP02612 (show subtarget assignments)	0	work_stopped	No	GBAA5170	50196964	dapF	diaminopimelate epimerase [Bacillus anth...	288	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2OTN	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP04272 (show subtarget assignments)	1	expressed	No	GBAA3899	47529188		lantibiotic biosynthesis sensor histidin...	453	putative drug target function;	Phase 4: April 2009	2C2A	14.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02304 (show subtarget assignments)	1	cloned	No	GBAA0703	47525984	qoxA	quinol oxidase, subunit II [Bacillus ant...	291	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FFT	33.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02611 (show subtarget assignments)	1	cloned	No	GBAA_pXO1_0111	47566431		M23/37 family peptidase [Bacillus anthra...	523	Drug target motif; Vaccine Target	Phase 3: June 2008	2GU1	10.1%	Bacillus anthracis	N/A	N/A

IDP04313 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2368	47527663	entA	2,3-dihydroxybenzoate-2,3-dehydrogenase ...	258	virulence factor; putative drug target function;	Phase 4: April 2009	2FWM	45.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04682 (show subtarget assignments)	1	cloned	No	GBAA3189	47528481		adhesion lipoprotein [Bacillus anthracis...	311	virulence factor; putative drug target function;	Phase 4: April 2009	3HH8	49.8%	Bacillus anthracis	Cell envelope	Other

IDP04688 (show subtarget assignments)	1	soluble	No	GBAA4661	47529959	nadC	nicotinate-nucleotide pyrophosphorylase ...	277	putative drug target function;	Phase 4: April 2009	1X1O	43.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP04691 (show subtarget assignments)	1	soluble	No	GBAA5067	47530367		sensory box histidine kinase [Bacillus a...	617	putative drug target function;	Phase 4: April 2009	3A0R	10.7%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02574 (show subtarget assignments)	1	cloned	No	GBAA1995	47527292		protease, putative [Bacillus anthracis s...	386	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01934 (show subtarget assignments)	1	soluble	No	GBAA0385	47525656		chitinase B [Bacillus anthracis str. 'Am...	674	Drug target motif; Drug target functions	Phase 3: June 2008	1ITX	37.4%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02575 (show subtarget assignments)	1	cloned	No	GBAA5123	47778366	glgB	glycogen branching enzyme [Bacillus anth...	645	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3K1D	43.4%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02576 (show subtarget assignments)	1	purified	No	GBAA0246	47525503	murF	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	458	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2AM1	37.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02573 (show subtarget assignments)	1	in_pdb 3ICC	No	GBAA1847	47527139		short chain dehydrogenase [Bacillus anth...	252	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3ICC	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP04674 (show subtarget assignments)	1	expressed	No	GBAA1956	47527252		sensor histidine kinase [Bacillus anthra...	351	putative drug target function;	Phase 4: April 2009	3A0R	23.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04675 (show subtarget assignments)	1	soluble	No	GBAA2291	47527591		sensor histidine kinase [Bacillus anthra...	377	putative drug target function;	Phase 4: April 2009	3A0R	26.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02568 (show subtarget assignments)	1	cloned	No	GBAA0295	47525558	purF	amidophosphoribosyltransferase [Bacillus...	471	Drug target motif; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AO0	69.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04109 (show subtarget assignments)	1	crystallized	No	GBAA3100	47528393		copper homeostasis protein CutC, putativ...	225	virulence factor; putative drug target function;	Phase 4: April 2009	2BDQ	30.7%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP04136 (show subtarget assignments)	1	diffraction	No	GBAA4258	47529551		5-methylthio-3-oxo-1-penten-1,2-diol dio...	170	putative drug target function;	Phase 4: April 2009	1ZRR	31.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02259 (show subtarget assignments)	1	cloned	No	GBAA2164	47527458		ABC transporter ATP-binding protein [Bac...	631	Conserved; Drug target functions	Phase 3: June 2008	1YQT	21.4%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02577 (show subtarget assignments)	1	purified	No	GBAA5546	47530866	atpC	F0F1 ATP synthase subunit epsilon [Bacil...	133	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2E5Y	69.9%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP04673 (show subtarget assignments)	1	purified	No	GBAA1498	47777938	resE	sensor histidine kinase ResE [Bacillus a...	591	putative drug target function;	Phase 4: April 2009	3A0R	15.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04676 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2370	47527665	dhbE	2,3-dihydroxybenzoate-AMP ligase [Bacill...	538	putative drug target function;	Phase 4: April 2009	1MD9	71.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02331 (show subtarget assignments)	1	selected	No	GBAA2661	47527952	adP-1	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	30.7%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02260 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA0072	47777774	folB	dihydroneopterin aldolase [Bacillus anth...	120	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1DHN	43.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02564 (show subtarget assignments)	1	purified	No	GBAA0084	47525340	ispD	2-C-methyl-D-erythritol 4-phosphate cyti...	226	Conserved; Drug target functions	Phase 3: June 2008	1W77	36.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01917 (show subtarget assignments)	1	soluble	No	GBAA1429	47526701	hisA	1-(5-phosphoribosyl)-5-[(5-phosphoribosy...	239	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VZW	36.5%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP01922 (show subtarget assignments)	1	expressed	No	GBAA1441	47526716	sat	sulfate adenylyltransferase [Bacillus an...	378	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1V47	39.4%	Bacillus anthracis	Central intermediary metabolism	Sulfur metabolism

IDP02566 (show subtarget assignments)	1	purified	No	GBAA3033	50196939	adP-2	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	31.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04669 (show subtarget assignments)	1	expressed	No	GBAA1351	47526623		sensor histidine kinase KinD [Bacillus a...	498	putative drug target function;	Phase 4: April 2009	3D36	15.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01915 (show subtarget assignments)	1	cloned	No	GBAA1421	47777930	leuB	3-isopropylmalate dehydrogenase [Bacillu...	354	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3U1H	60.3%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP04670 (show subtarget assignments)	1	expressed	No	GBAA1356	47526628	kinB-1	sporulation kinase B [Bacillus anthracis...	402	putative drug target function;	Phase 4: April 2009	3D36	25.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01913 (show subtarget assignments)	1	cloned	No	GBAA1426	47526698	hisD	histidinol dehydrogenase [Bacillus anthr...	429	Conserved; Drug target functions	Phase 3: June 2008	1K75	39.2%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP02253 (show subtarget assignments)	1	soluble	No	GBAA1968	47527263	hom-1	homoserine dehydrogenase [Bacillus anthr...	431	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3MTJ	37.1%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP04671 (show subtarget assignments)	1	soluble	No	GBAA1416	47526688	ilvE-1	branched-chain amino acid aminotransfera...	298	conserved gene; putative drug target function;	Phase 4: April 2009	1WRV	40.3%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP04672 (show subtarget assignments)	1	expressed	No	GBAA1482	47526755		sensor histidine kinase [Bacillus anthra...	603	putative drug target function;	Phase 4: April 2009	3A0R	14.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04677 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2371	47527666	dhbB	isochorismatase [Bacillus anthracis str....	295	putative drug target function;	Phase 4: April 2009	2FQ1	45.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01888 (show subtarget assignments)	1	cloned	No	GBAA5730	47531066	soJ	sporulation initiation inhibitor protein...	253	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1WCV	48.6%	Bacillus anthracis	Regulatory functions	Other

IDP01887 (show subtarget assignments)	1	expressed	No	GBAA5729	47531065	spo0J	stage 0 sporulation protein J [Bacillus ...	256	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	36.3%	Bacillus anthracis	Cellular processes	Sporulation and germination

IDP02617 (show subtarget assignments)	1	expressed	No	GBAA1286	47526551		D-alanyl-D-alanine carboxypeptidase fami...	428	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3MFD	24.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01885 (show subtarget assignments)	1	cloned	No	GBAA5639	47530965		D-alanyl-D-alanine carboxypeptidase, put...	423	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01892 (show subtarget assignments)	1	in_pdb 3HVU 3KB8 3H83	No	GBAA0063	47525317	hpt-1	hypoxanthine-guanine phosphoribosyltrans...	180	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3H83	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP04076 (show subtarget assignments)	1	expressed	No	GBAA2213	47527506		sensor histidine kinase [Bacillus anthra...	452	putative drug target function;	Phase 4: April 2009	2C2A	18.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01906 (show subtarget assignments)	1	soluble	No	GBAA0294	47525557	purL	phosphoribosylformylglycinamidine syntha...	739	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3AC6	46.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01881 (show subtarget assignments)	1	cloned	No	GBAA0009	47525265	dacA	D-alanyl-D-alanine carboxypeptidase [Bac...	435	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02244 (show subtarget assignments)	1	cloned	No	GBAA1818	47777969		N-acetylmuramoyl-L-alanine amidase [Baci...	459	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PYW	12.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01876 (show subtarget assignments)	1	cloned	No	GBAA0095	47525349	secE	preprotein translocase subunit SecE [Bac...	59	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DIN	33.9%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP01877 (show subtarget assignments)	1	crystallized	No	GBAA0080	47525336		negative regulator of genetic competence...	811	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PXI	80.1%	Bacillus anthracis	Cellular processes	DNA transformation

IDP02245 (show subtarget assignments)	1	cloned	No	GBAA1751	47527043	asnO-2	asparagine synthetase, glutamine-hydroly...	607	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1CT9	25.9%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP04427 (show subtarget assignments)	1	expressed	No	GBAA4784	47530081		iron compound ABC transporter, ATP-bindi...	256	virulence factor; putative drug target function;	Phase 4: April 2009	1F3O	32.4%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01872 (show subtarget assignments)	1	cloned	No	GBAA5706	47531042		oligoendopeptidase F, putative [Bacillus...	605	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	2QR4	29.3%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01874 (show subtarget assignments)	1	cloned	No	GBAA0062	47525316		hypothetical protein GBAA0062 [Bacillus ...	476	Conserved;	Phase 3: June 2008	3A2K	46.6%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP05031
(show subtarget assignments)

1

soluble

No

BA_0908

30254654

oligopeptide ABC transporter, oligopepti...

528

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XOC

30.7%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP04422
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4023

47529316

pyrD

dihydroorotate dehydrogenase 1B [Bacillu...

309

putative drug target function;

Phase 4: April 2009

1EP1

68%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02277
(show subtarget assignments)

1

crystallized

No

GBAA1434

47526709

glycerate dehydrogenase [Bacillus anthra...

323

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2DBQ

48.6%

Bacillus anthracis

Central intermediary metabolism

Other

IDP02273
(show subtarget assignments)

1

expressed

No

GBAA3714

47528998

hypothetical protein GBAA3714 [Bacillus ...

315

Conserved; Essential;

Phase 3: June 2008

3CCF

14.3%

Bacillus anthracis

Hypothetical proteins

Domain

IDP02603
(show subtarget assignments)

1

expressed

No

GBAA4274

47529567

nagA

N-acetylglucosamine-6-phosphate deacetyl...

380

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2VHL

44%

Bacillus anthracis

Central intermediary metabolism

Amino sugars

IDP04423
(show subtarget assignments)

1

in_pdb
3M3H
3OSC

Yes

GBAA4021

47529314

pyrE

orotate phosphoribosyltransferase [Bacil...

210

conserved gene; putative drug target function;

Phase 4: April 2009

3M3H

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02328
(show subtarget assignments)

1

expressed

No

GBAA2548

47527837

acetyl-CoA carboxylase biotin carboxylas...

445

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3N6R

51.9%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02300
(show subtarget assignments)

1

soluble

No

GBAA1860

47527151

alpha/beta fold family hydrolase [Bacill...

307

Drug target motif; Involved in sporulation;

Phase 3: June 2008

3HJU

26.7%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02272
(show subtarget assignments)

1

cloned

No

GBAA2183

47527475

neutral metalloprotease, putative [Bacil...

503

Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...

Phase 3: June 2008

1BQB

14.3%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02005
(show subtarget assignments)

1

cloned

No

GBAA0543

47525816

penicillin-binding domain-containing pro...

258

Drug target homolog; Involved in sporulation;

Phase 3: June 2008

2OQO

36%

Bacillus anthracis

Unknown function

General

IDP02609
(show subtarget assignments)

1

in_pdb
3LQN

Yes

GBAA4196

47529491

CBS domain-containing protein [Bacillus ...

147

Drug target motif;

Phase 3: June 2008

3LQN

100%

Bacillus anthracis

Unknown function

General

IDP02325
(show subtarget assignments)

1

in_pdb
3IMF

No

GBAA4204

47778260

short chain dehydrogenase [Bacillus anth...

254

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3IMF

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02601
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2462

47527752

PTS system, cellobiose-specific IIB comp...

101

Conserved; Essential; Drug target functions

Phase 3: June 2008

2L2Q

29.7%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04421
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4022

47529315

pyrF

orotidine 5'-phosphate decarboxylase [Ba...

238

putative drug target function;

Phase 4: April 2009

1DBT

61.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04424
(show subtarget assignments)

1

purified

No

GBAA4024

47529317

pyrK

dihydroorotate dehydrogenase electron tr...

259

putative drug target function;

Phase 4: April 2009

1EP3

48.6%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02318
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1251

47526517

trpC

indole-3-glycerol-phosphate synthase [Ba...

253

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3TSM

40.7%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02592
(show subtarget assignments)

1

expressed

No

GBAA1308

47526573

glycolate oxidase, iron-sulfur subunit, ...

442

Conserved; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Energy metabolism

Other

IDP04419
(show subtarget assignments)

1

soluble

No

GBAA2861

47528156

sensor histidine kinase SrrB, putative [...

458

putative drug target function;

Phase 4: April 2009

2C2A

18.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02319
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1169

47526434

prsA

peptidylprolyl isomerase [Bacillus anthr...

285

Drug target motif; Drug target functions

Phase 3: June 2008

3RFW

29.5%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP02596
(show subtarget assignments)

1

cloned

No

GBAA1269

47526536

odhB

dihydrolipoamide acetyltransferase [Baci...

418

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

38.1%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP04425
(show subtarget assignments)

1

cloned

No

GBAA4025

47529318

carB

carbamoyl phosphate synthase large subun...

1072

conserved gene; putative drug target function;

Phase 4: April 2009

1BXR

49.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02329
(show subtarget assignments)

1

in_pdb
3KQF

Yes

GBAA2551

47527840

enoyl-CoA hydratase [Bacillus anthracis ...

262

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3KQF

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP02093
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1970

47527265

thrB

homoserine kinase [Bacillus anthracis st...

297

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HUL

46.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP04397
(show subtarget assignments)

1

expressed

No

GBAA3230

47528520

sensor histidine kinase [Bacillus anthra...

457

putative drug target function;

Phase 4: April 2009

2C2A

17.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02314
(show subtarget assignments)

1

cloned

No

GBAA0599

47525877

neutral protease [Bacillus anthracis str...

566

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1NPC

53%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02320
(show subtarget assignments)

1

purified

No

GBAA1254

47526520

trpA

tryptophan synthase subunit alpha [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1UJP

39.1%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP04420
(show subtarget assignments)

1

cloned

No

GBAA3308

47528594

sdhB-1

l-serine dehydratase, iron-sulfur-depend...

232

virulence factor; putative drug target function;

Phase 4: April 2009

2IQQ

15.5%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP04689
(show subtarget assignments)

1

in_pdb
3PEA

Yes

GBAA4761

47530060

enoyl-CoA hydratase [Bacillus anthracis ...

258

conserved gene; putative drug target function;

Phase 4: April 2009

3PEA

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP04690
(show subtarget assignments)

1

expressed

No

GBAA5029

47530328

sensor histidine kinase [Bacillus anthra...

418

putative drug target function;

Phase 4: April 2009

3D36

17.7%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04369
(show subtarget assignments)

1

expressed

No

GBAA1792

47527081

sensor histidine kinase, putative [Bacil...

368

putative drug target function;

Phase 4: April 2009

3GIG

17.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02267
(show subtarget assignments)

1

soluble

No

GBAA0987

47526266

hypothetical protein GBAA0987 [Bacillus ...

66

Conserved;

Phase 3: June 2008

Bacillus anthracis

Hypothetical proteins

Conserved

IDP04685
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3438

47528724

alcohol dehydrogenase, zinc-containing [...

335

virulence factor; putative drug target function;

Phase 4: April 2009

3GAZ

37.3%

Bacillus anthracis

Energy metabolism

Fermentation

IDP04352
(show subtarget assignments)

1

soluble

No

GBAA0584

47525859

sensor histidine kinase [Bacillus anthra...

487

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

17%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02583
(show subtarget assignments)

1

soluble

No

GBAA5249

47530554

3-hydroxyacyl-CoA dehydrogenase/enoyl-Co...

793

Conserved; Drug target functions

Phase 3: June 2008

1WDK

14.6%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP04370
(show subtarget assignments)

1

cloned

No

GBAA4766

47530065

iron compound ABC transporter, iron comp...

324

virulence factor; putative drug target function;

Phase 4: April 2009

3EIW

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP04686
(show subtarget assignments)

1

expressed

No

GBAA4223

47529516

kinB-3

sporulation kinase B [Bacillus anthracis...

424

putative drug target function;

Phase 4: April 2009

3D36

22.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02280
(show subtarget assignments)

1

in_pdb
3L44

Yes

GBAA0531

47525801

hemL-1

glutamate-1-semialdehyde aminotransferas...

434

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3L44

99.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02315
(show subtarget assignments)

1

cloned

No

GBAA1132

47526402

aceA

isocitrate lyase [Bacillus anthracis str...

425

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I4E

71.4%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP04371
(show subtarget assignments)

1

expressed

No

GBAA4776

47778322

sensor histidine kinase [Bacillus anthra...

311

putative drug target function;

Phase 4: April 2009

2C2A

19.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02330
(show subtarget assignments)

1

cloned

No

GBAA1419

47526691

ilvC-1

ketol-acid reductoisomerase [Bacillus an...

336

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1NP3

55.7%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP04342
(show subtarget assignments)

1

cloned

No

GBAA1564

47526837

panD

aspartate alpha-decarboxylase [Bacillus ...

127

conserved gene; putative drug target function;

Phase 4: April 2009

2C45

52.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04683
(show subtarget assignments)

1

expressed

No

GBAA3269

47528557

iron-sulfur cluster-binding protein [Bac...

470

virulence factor; putative drug target function;

Phase 4: April 2009

Bacillus anthracis

Energy metabolism

Electron transport

IDP04687
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4340

47529637

bioD

dithiobiotin synthetase [Bacillus anthra...

242

putative drug target function;

Phase 4: April 2009

1A82

26.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04679
(show subtarget assignments)

1

expressed

No

GBAA2644

47527936

kinB-2

sporulation kinase B [Bacillus anthracis...

422

putative drug target function;

Phase 4: April 2009

3D36

27.7%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02263
(show subtarget assignments)

1

in_pdb
3U7I

Yes

GBAA0966

47526249

hypothetical protein GBAA0966 [Bacillus ...

220

Conserved; Essential;

Phase 3: June 2008

3U7I

100%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP04680
(show subtarget assignments)

1

expressed

No

GBAA3066

47528358

sensor histidine kinase, putative [Bacil...

333

putative drug target function;

Phase 4: April 2009

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02298
(show subtarget assignments)

1

soluble

No

GBAA0555

47525828

collagenase,putative [Bacillus anthracis...

965

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

2Y3U

39.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04426
(show subtarget assignments)

1

expressed

No

GBAA4339

47529636

bioF

8-amino-7-oxononanoate synthase [Bacillu...

395

putative drug target function;

Phase 4: April 2009

3A2B

33.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04681
(show subtarget assignments)

1

soluble

No

GBAA3131

47528422

adhB

alcohol dehydrogenase, zinc-containing [...

377

virulence factor; putative drug target function;

Phase 4: April 2009

1KOL

31.9%

Bacillus anthracis

Energy metabolism

Fermentation

IDP02612
(show subtarget assignments)

0

work_stopped

No

GBAA5170

50196964

dapF

diaminopimelate epimerase [Bacillus anth...

288

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2OTN

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP04272
(show subtarget assignments)

1

expressed

No

GBAA3899

47529188

lantibiotic biosynthesis sensor histidin...

453

putative drug target function;

Phase 4: April 2009

2C2A

14.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02304
(show subtarget assignments)

1

cloned

No

GBAA0703

47525984

qoxA

quinol oxidase, subunit II [Bacillus ant...

291

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FFT

33.7%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02611
(show subtarget assignments)

1

cloned

No

GBAA_pXO1_0111

47566431

M23/37 family peptidase [Bacillus anthra...

523

Drug target motif; Vaccine Target

Phase 3: June 2008

2GU1

10.1%

Bacillus anthracis

N/A

IDP04313
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2368

47527663

entA

2,3-dihydroxybenzoate-2,3-dehydrogenase ...

258

virulence factor; putative drug target function;

Phase 4: April 2009

2FWM

45.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04682
(show subtarget assignments)

1

cloned

No

GBAA3189

47528481

adhesion lipoprotein [Bacillus anthracis...

311

virulence factor; putative drug target function;

Phase 4: April 2009

3HH8

49.8%

Bacillus anthracis

Cell envelope

Other

IDP04688
(show subtarget assignments)

1

soluble

No

GBAA4661

47529959

nadC

nicotinate-nucleotide pyrophosphorylase ...

277

putative drug target function;

Phase 4: April 2009

1X1O

43.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP04691
(show subtarget assignments)

1

soluble

No

GBAA5067

47530367

sensory box histidine kinase [Bacillus a...

617

putative drug target function;

Phase 4: April 2009

3A0R

10.7%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02574
(show subtarget assignments)

1

cloned

No

GBAA1995

47527292

protease, putative [Bacillus anthracis s...

386

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01934
(show subtarget assignments)

1

soluble

No

GBAA0385

47525656

chitinase B [Bacillus anthracis str. 'Am...

674

Drug target motif; Drug target functions

Phase 3: June 2008

1ITX

37.4%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02575
(show subtarget assignments)

1

cloned

No

GBAA5123

47778366

glgB

glycogen branching enzyme [Bacillus anth...

645

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3K1D

43.4%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02576
(show subtarget assignments)

1

purified

No

GBAA0246

47525503

murF

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

458

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2AM1

37.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02573
(show subtarget assignments)

1

in_pdb
3ICC

No

GBAA1847

47527139

short chain dehydrogenase [Bacillus anth...

252

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3ICC

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP04674
(show subtarget assignments)

1

expressed

No

GBAA1956

47527252

sensor histidine kinase [Bacillus anthra...

351

putative drug target function;

Phase 4: April 2009

3A0R

23.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04675
(show subtarget assignments)

1

soluble

No

GBAA2291

47527591

sensor histidine kinase [Bacillus anthra...

377

putative drug target function;

Phase 4: April 2009

3A0R

26.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02568
(show subtarget assignments)

1

cloned

No

GBAA0295

47525558

purF

amidophosphoribosyltransferase [Bacillus...

471

Drug target motif; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AO0

69.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04109
(show subtarget assignments)

1

crystallized

No

GBAA3100

47528393

copper homeostasis protein CutC, putativ...

225

virulence factor; putative drug target function;

Phase 4: April 2009

2BDQ

30.7%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP04136
(show subtarget assignments)

1

diffraction

No

GBAA4258

47529551

5-methylthio-3-oxo-1-penten-1,2-diol dio...

170

putative drug target function;

Phase 4: April 2009

1ZRR

31.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02259
(show subtarget assignments)

1

cloned

No

GBAA2164

47527458

ABC transporter ATP-binding protein [Bac...

631

Conserved; Drug target functions

Phase 3: June 2008

1YQT

21.4%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02577
(show subtarget assignments)

1

purified

No

GBAA5546

47530866

atpC

F0F1 ATP synthase subunit epsilon [Bacil...

133

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2E5Y

69.9%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP04673
(show subtarget assignments)

1

purified

No

GBAA1498

47777938

resE

sensor histidine kinase ResE [Bacillus a...

591

putative drug target function;

Phase 4: April 2009

3A0R

15.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04676
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2370

47527665

dhbE

2,3-dihydroxybenzoate-AMP ligase [Bacill...

538

putative drug target function;

Phase 4: April 2009

1MD9

71.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02331
(show subtarget assignments)

1

selected

No

GBAA2661

47527952

adP-1

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

30.7%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02260
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA0072

47777774

folB

dihydroneopterin aldolase [Bacillus anth...

120

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1DHN

43.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02564
(show subtarget assignments)

1

purified

No

GBAA0084

47525340

ispD

2-C-methyl-D-erythritol 4-phosphate cyti...

226

Conserved; Drug target functions

Phase 3: June 2008

1W77

36.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01917
(show subtarget assignments)

1

soluble

No

GBAA1429

47526701

hisA

1-(5-phosphoribosyl)-5-[(5-phosphoribosy...

239

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VZW

36.5%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP01922
(show subtarget assignments)

1

expressed

No

GBAA1441

47526716

sat

sulfate adenylyltransferase [Bacillus an...

378

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1V47

39.4%

Bacillus anthracis

Central intermediary metabolism

Sulfur metabolism

IDP02566
(show subtarget assignments)

1

purified

No

GBAA3033

50196939

adP-2

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

31.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04669
(show subtarget assignments)

1

expressed

No

GBAA1351

47526623

sensor histidine kinase KinD [Bacillus a...

498

putative drug target function;

Phase 4: April 2009

3D36

15.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01915
(show subtarget assignments)

1

cloned

No

GBAA1421

47777930

leuB

3-isopropylmalate dehydrogenase [Bacillu...

354

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3U1H

60.3%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP04670
(show subtarget assignments)

1

expressed

No

GBAA1356

47526628

kinB-1

sporulation kinase B [Bacillus anthracis...

402

putative drug target function;

Phase 4: April 2009

3D36

25.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01913
(show subtarget assignments)

1

cloned

No

GBAA1426

47526698

hisD

histidinol dehydrogenase [Bacillus anthr...

429

Conserved; Drug target functions

Phase 3: June 2008

1K75

39.2%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP02253
(show subtarget assignments)

1

soluble

No

GBAA1968

47527263

hom-1

homoserine dehydrogenase [Bacillus anthr...

431

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3MTJ

37.1%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP04671
(show subtarget assignments)

1

soluble

No

GBAA1416

47526688

ilvE-1

branched-chain amino acid aminotransfera...

298

conserved gene; putative drug target function;

Phase 4: April 2009

1WRV

40.3%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP04672
(show subtarget assignments)

1

expressed

No

GBAA1482

47526755

sensor histidine kinase [Bacillus anthra...

603

putative drug target function;

Phase 4: April 2009

3A0R

14.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04677
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2371

47527666

dhbB

isochorismatase [Bacillus anthracis str....

295

putative drug target function;

Phase 4: April 2009

2FQ1

45.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01888
(show subtarget assignments)

1

cloned

No

GBAA5730

47531066

soJ

sporulation initiation inhibitor protein...

253

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1WCV

48.6%

Bacillus anthracis

Regulatory functions

Other

IDP01887
(show subtarget assignments)

1

expressed

No

GBAA5729

47531065

spo0J

stage 0 sporulation protein J [Bacillus ...

256

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

36.3%

Bacillus anthracis

Cellular processes

Sporulation and germination

IDP02617
(show subtarget assignments)

1

expressed

No

GBAA1286

47526551

D-alanyl-D-alanine carboxypeptidase fami...

428

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3MFD

24.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01885
(show subtarget assignments)

1

cloned

No

GBAA5639

47530965

D-alanyl-D-alanine carboxypeptidase, put...

423

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01892
(show subtarget assignments)

1

in_pdb
3HVU
3KB8
3H83

No

GBAA0063

47525317

hpt-1

hypoxanthine-guanine phosphoribosyltrans...

180

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3H83

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP04076
(show subtarget assignments)

1

expressed

No

GBAA2213

47527506

sensor histidine kinase [Bacillus anthra...

452

putative drug target function;

Phase 4: April 2009

2C2A

18.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01906
(show subtarget assignments)

1

soluble

No

GBAA0294

47525557

purL

phosphoribosylformylglycinamidine syntha...

739

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3AC6

46.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01881
(show subtarget assignments)

1

cloned

No

GBAA0009

47525265

dacA

D-alanyl-D-alanine carboxypeptidase [Bac...

435

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02244
(show subtarget assignments)

1

cloned

No

GBAA1818

47777969

N-acetylmuramoyl-L-alanine amidase [Baci...

459

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PYW

12.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01876
(show subtarget assignments)

1

cloned

No

GBAA0095

47525349

secE

preprotein translocase subunit SecE [Bac...

59

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DIN

33.9%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP01877
(show subtarget assignments)

1

crystallized

No

GBAA0080

47525336

negative regulator of genetic competence...

811

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PXI

80.1%

Bacillus anthracis

Cellular processes

DNA transformation

IDP02245
(show subtarget assignments)

1

cloned

No

GBAA1751

47527043

asnO-2

asparagine synthetase, glutamine-hydroly...

607

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1CT9

25.9%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP04427
(show subtarget assignments)

1

expressed

No

GBAA4784

47530081

iron compound ABC transporter, ATP-bindi...

256

virulence factor; putative drug target function;

Phase 4: April 2009

1F3O

32.4%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01872
(show subtarget assignments)

1

cloned

No

GBAA5706

47531042

oligoendopeptidase F, putative [Bacillus...

605

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

2QR4

29.3%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01874
(show subtarget assignments)

1

cloned

No

GBAA0062

47525316

hypothetical protein GBAA0062 [Bacillus ...

476

Conserved;

Phase 3: June 2008

3A2K

46.6%

Bacillus anthracis

Hypothetical proteins

Conserved

Targets