Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02172 (show subtarget assignments)	1	cloned	No	YPO0893	16121198	fldB	flavodoxin FldB [Yersinia pestis CO92]	172	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1FLV	46.5%	Yersinia pestis	Energy metabolism	Electron transport

IDP04099 (show subtarget assignments)	1	expressed	No	VC1027	9655490		molybdenum cofactor biosynthesis protein...	81	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1FM0	70.4%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP92121 (show subtarget assignments)	8	selected	No	ADC80547	289064343		methionyl-tRNA formyltransferase [Toxopl...	885	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1FMT	10.3%	Toxoplasma gondii

IDP04083 (show subtarget assignments)	1	cloned	No	YPO1631	218928767	pepT	peptidase T [Yersinia pestis CO92]	411	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1FNO	76.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01063 (show subtarget assignments)	1	soluble	No	STM3702	16766987	grxC	glutaredoxin 3	83	Conserved Gene / Pathway	Phase 2: March 2008	1FOV	86.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP05343 (show subtarget assignments)	1	soluble	No	Z1544	12514412		putative acyl-carrier protein synthase [...	122	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1FTE	36.1%	Escherichia coli	Fatty acid and phospholipid metabolism: Biosynthesis

IDP01626 (show subtarget assignments)	1	cloned	No	GBAA5017	47530320	metK	S-adenosylmethionine synthetase [Bacillu...	399	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FUG	62.4%	Bacillus anthracis	Central intermediary metabolism	Other

IDP90798 (show subtarget assignments)	8	in_crystallization_trials	No	VC0472	15640499		S-adenosylmethionine synthetase [Vibrio ...	385	Predicted Essential	Community Requests	1FUG	87.5%	Vibrio cholerae

IDP00748 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1837	57284761	metK	S-adenosylmethionine synthetase	397	Drug Target Function	Phase 2: March 2008	1FUG	62.2%	Staphylococcus aureus	Central intermediary metabolism	One-carbon metabolism

IDP04492 (show subtarget assignments)	1	cloned	No	YPO3834	218930837	pldA	phospholipase A [Yersinia pestis CO92]	292	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1FW2	69.2%	Yersinia pestis	Fatty acid and phospholipid metabolism	Degradation

IDP90584 (show subtarget assignments)	8	purified	No	VC0095	15640127		chorismate--pyruvate lyase [Vibrio chole...	183	Predicted Essential	Community Requests	1FW9	28.4%	Vibrio cholerae

IDP90656 (show subtarget assignments)	8	purified	No	Cj0384c	15791751	kdsA	2-dehydro-3-deoxyphosphooctonate aldolas...	271	Predicted Essential	Community Requests	1FWN	55.7%	Campylobacter jejuni

IDP90144 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_189.5	68449261		bifunctional IL-1-beta-inhibitor/prevent...	126	contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184	Community Requests	1G0Y	27.8%	Monkeypox virus

IDP02012 (show subtarget assignments)	1	soluble	No	STM4233	16767483	ubiC	chorismate pyruvate lyase [Salmonella ty...	165	Conserved; Drug target functions	Phase 3: June 2008	1G1B	86.1%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP90522 (show subtarget assignments)	8	in_crystallization_trials	No	YPO0310	16120648	ubiC	chorismate pyruvate lyase [Yersinia pest...	174	Predicted Essential	Community Requests	1G1B	50.6%	Yersinia pestis

IDP02114 (show subtarget assignments)	1	purified	No	FTT0688c	56707808	hslV	ATP-dependent protease peptidase subunit...	183	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1G3I	59.6%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP00672 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1271	57286009	hslU	ATP-dependent protease ATP-binding subun...	467	Drug Target Function	Phase 2: March 2008	1G3I	47.1%	Staphylococcus aureus	Protein fate	Protein folding and stabilization

IDP01450 (show subtarget assignments)	1	in_crystallization_trials	No	VC2269	15642267		3,4-dihydroxy-2-butanone 4-phosphate syn...	369	Drug Target Function	Phase 2: March 2008	1G57	30.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00332 (show subtarget assignments)	1	purified	No	FTT1673	56708683	ribA	riboflavin biosynthesis protein ribA/GTP...	403	Drug Target Function	Phase 2: March 2008	1G57	27%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02798 (show subtarget assignments)	1	purified	No	GBAA5049	47530348		carbonic anhydrase [Bacillus anthracis s...	187	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1G5C	34.8%	Bacillus anthracis	Central intermediary metabolism	Other

IDP90845 (show subtarget assignments)	8	selected	No	S1357	30062792	btuR	cob(I)yrinic acid a,c-diamide adenosyltr...	196	Predicted Essential	Community Requests	1G5R	88.3%	Shigella flexneri

IDP90638 (show subtarget assignments)	8	soluble	No	VC1040	15641053		cob(I)yrinic acid a,c-diamide adenosyltr...	201	Predicted Essential	Community Requests	1G5R	64.2%	Vibrio cholerae

IDP04469 (show subtarget assignments)	1	cloned	No	YPO2214	115347921	btuR	cob(I)alamin adenosyltransferase [Yersin...	196	conserved gene; putative drug target function;	Phase 4: April 2009	1G5R	78.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP91355 (show subtarget assignments)	8	soluble	No	VV1_3022	27366292		cob(I)yrinic acid a,c-diamide adenosyltr...	211	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1G5R	59.2%	Vibrio vulnificus

IDP01352 (show subtarget assignments)	1	soluble	No	VCA0447	15601210		haemagglutinin associated protein	230	Conserved Gene / Pathway	Phase 2: March 2008	1G60	29.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01121 (show subtarget assignments)	1	expressed	No	BA_1933	30256591		branched-chain amino acid ABC transporte...	257	Conserved Gene / Pathway	Phase 2: March 2008	1G6H	31.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP91810 (show subtarget assignments)	8	soluble	No	b3357	1789756	crp	DNA-binding transcriptional dual regulat...	210	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1G6N	100%	Escherichia coli

IDP00946 (show subtarget assignments)	1	expressed	No	STM0978	16764338	aroA	3-phosphoshikimate 1-carboxyvinyltransfe...	427	Conserved Gene / Pathway	Phase 2: March 2008	1G6S	89.5%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP90726 (show subtarget assignments)	8	purified	No	YPO1390	16121670	aroA	3-phosphoshikimate 1-carboxyvinyltransfe...	428	Predicted Essential	Community Requests	1G6S	80.1%	Yersinia pestis

IDP92116 (show subtarget assignments)	8	selected	No	TGME49_060680	237831887		DNA primase small subunit, putative [Tox...	509	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1G71	9.2%	Toxoplasma gondii

IDP04471 (show subtarget assignments)	1	purified	No	YPO2370	218929461	pdxH	pyridoxamine 5'-phosphate oxidase [Yersi...	217	conserved gene; putative drug target function;	Phase 4: April 2009	1G76	78.4%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP04507 (show subtarget assignments)	1	crystallized	No	VCA1079	9658525		pyridoxamine 5`-phosphate oxidase [Vibri...	211	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1G76	65.9%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP00884 (show subtarget assignments)	1	purified	No	STM1925	16765267	flhD	transcriptional activator FlhD	116	Conserved Gene / Pathway	Phase 2: March 2008	1G8E	89.7%	Salmonella enterica	Cell envelope	Surface structures

IDP01179 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0048	81583548		Bifunctional protein glmU [Includes: UDP...	459	Drug Target Function	Phase 2: March 2008	1G95	51.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00656 (show subtarget assignments)	1	cloned	No	SACOL0543	57284226	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	450	Drug Target Function	Phase 2: March 2008	1G95	49.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91618 (show subtarget assignments)	8	expressed	No	BAB36097	13362142	ECs2674	hypothetical protein [Escherichia coli O...	379	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1G9U	13.7%	Escherichia coli

IDP91619 (show subtarget assignments)	8	soluble	No	BAB36095	13362140	ECs2672	hypothetical protein [Escherichia coli O...	379	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1G9U	13.5%	Escherichia coli

IDP05568 (show subtarget assignments)	1	cloned	No	S4492	30043719	valS	valine tRNA synthetase [Shigella flexner...	951	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GAX	39.9%	Shigella flexneri	Protein synthesis: tRNA aminoacylation

IDP05758 (show subtarget assignments)	1	cloned	No	lmo1552	16803592	valS	valyl-tRNA synthetase [Listeria monocyto...	883	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GAX	40%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP04005 (show subtarget assignments)	1	purified	No	BAS4355	49187350		valyl-tRNA synthetase [Bacillus anthraci...	881	Proposed to be essential proteins	Phase 4: April 2009	1GAX	42.6%	Bacillus anthracis

IDP05578 (show subtarget assignments)	1	cloned	No	SACOL1710	57650536	valS	valyl-tRNA synthetase [Staphylococcus au...	876	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GAX	40.2%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP90658 (show subtarget assignments)	8	cloned	No	VC2503	15642499	valS	valyl-tRNA synthetase [Vibrio cholerae O...	953	Predicted Essential	Community Requests	1GAX	38.8%	Vibrio cholerae

IDP92132 (show subtarget assignments)	8	selected	No	TGME49_053290	237840177		valyl-tRNA synthetase, putative [Toxopla...	1042	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1GAX	35.3%	Toxoplasma gondii

IDP90598 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3443	16123591	valS	valyl-tRNA synthetase [Yersinia pestis C...	965	Predicted Essential	Community Requests	1GAX	40.5%	Yersinia pestis

IDP05749 (show subtarget assignments)	1	cloned	No	Cj0775c	6968216	valS	putative periplasmic protein [Campylobac...	870	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GAX	38.2%	Campylobacter jejuni	Protein synthesis: tRNA aminoacylation

IDP92102 (show subtarget assignments)	8	selected	No	TGME49_069110	237832613		ornithine aminotransferase, putative [To...	441	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1GBN	47.2%	Toxoplasma gondii

IDP00587 (show subtarget assignments)	1	cloned	No	YPO1507	16121780	mglB	galactose-binding protein	335	Virulence Associated Factor	Phase 2: March 2008	1GCA	80.9%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01639 (show subtarget assignments)	1	cloned	No	GBAA4225	47529518		aminotransferase A [Bacillus anthracis s...	387	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1GD9	39.5%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01606 (show subtarget assignments)	1	cloned	No	GBAA4968	47530266	gdH	glucose-1-dehydrogenase [Bacillus anthra...	261	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GEE	87.7%	Bacillus anthracis	Energy metabolism	Other

IDP02610 (show subtarget assignments)	1	expressed	No	Cj1417c	15792735		hypothetical protein Cj1417c [Campylobac...	200	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1GEE	87.7%	Campylobacter jejuni	Cell envelope	Other

IDP02152 (show subtarget assignments)	1	soluble	No	FTT0955c	56708049	gor	glutathione reductase [Francisella tular...	453	Conserved; Drug target functions	Phase 3: June 2008	1GER	49.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP92095 (show subtarget assignments)	8	selected	No	TGME49_046920	237835543		glutathione reductase, putative [Toxopla...	483	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1GER	46.2%	Toxoplasma gondii

IDP91210 (show subtarget assignments)	8	expressed	No	BLIJ_0364	189439941	aroG2	phospho-2-dehydro-3-deoxyheptonate aldol...	377	potential drug target / Shikimate pathway enzyme	Community Requests	1GG1	47.7%	Bifidobacterium longum

IDP91163 (show subtarget assignments)	8	cloned	No	VC1507	15641516		phospho-2-dehydro-3-deoxyheptonate aldol...	395	potential drug target / Shikimate pathway enzyme	Community Requests	1GG1	48.9%	Vibrio cholerae

IDP01013 (show subtarget assignments)	1	purified	No	STM2670	16765985	aroF	phospho-2-dehydro-3-deoxyheptonate aldol...	356	Conserved Gene / Pathway	Phase 2: March 2008	1GG1	51.4%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP91164 (show subtarget assignments)	8	purified	No	VC0695	15640714		phospho-2-dehydro-3-deoxyheptonate aldol...	357	potential drug target / Shikimate pathway enzyme	Community Requests	1GG1	50.7%	Vibrio cholerae

IDP90850 (show subtarget assignments)	8	soluble	No	YPO0551	16120879	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	458	Predicted Essential	Community Requests	1GG4	69.9%	Yersinia pestis

IDP05742 (show subtarget assignments)	1	cloned	No	CD2655	126700269	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	457	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1GG4	31.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02368 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0422	56707569	murF	UDP-N--acetylmuramoylalanyl-D-glutamyl-2...	452	Conserved; Drug target functions	Phase 3: June 2008	1GG4	33.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01455 (show subtarget assignments)	1	purified	No	VC2405	15642402		UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	453	Conserved Gene / Pathway	Phase 2: March 2008	1GG4	52.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02731 (show subtarget assignments)	1	expressed	No	CBU_0124	29540744	murF	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	446	Conserved; Drug target functions	Phase 3: June 2008	1GG4	43.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00904 (show subtarget assignments)	0	work_stopped	No	STM0124	16763514	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	452	Conserved Gene / Pathway	Phase 2: March 2008	1GG4	87.6%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91966 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100001092	298254195		ABC transporter substrate-binding protei...	271	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1GGG	28.4%	Streptococcus pneumoniae

IDP01356 (show subtarget assignments)	1	soluble	No	VC0010	15640042		amino acid ABC transporter, periplasmic ...	248	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	31.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP91402 (show subtarget assignments)	8	purified	No	VV1_1001	27364435		ABC-type amino acid transport, signal tr...	250	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1GGG	31.2%	Vibrio vulnificus

IDP00474 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2512	16122733	glnH	glutamine ABC transporter periplasmic pr...	247	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	78.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01317 (show subtarget assignments)	1	soluble	No	VC0966	15640982		phosphocarrier protein HPr	85	Conserved Gene / Pathway	Phase 2: March 2008	1GGR	75.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00719 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1457	57284566		PTS system, IIA component	166	Conserved Gene / Pathway	Phase 2: March 2008	1GGR	41%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP91826 (show subtarget assignments)	8	expressed	No	b2415	1788755	ptsH	phosphohistidinoprotein-hexose phosphotr...	85	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1GGR	100%	Escherichia coli

IDP01237 (show subtarget assignments)	1	purified	No	BA_5563	46396830		Glucose-specific phosphotransferase enzy...	165	Drug Target Function	Phase 2: March 2008	1GGR	46.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01855 (show subtarget assignments)	1	soluble	No	STM1162	16764518	dinI	DNA damage-inducible protein I [Salmonel...	81	Conserved; Drug target functions	Phase 3: June 2008	1GHH	85.2%	Salmonella enterica	Unknown function	General

IDP00593 (show subtarget assignments)	1	expressed	No	YPO1232	16121518	msgA	putative stress response protein	80	Conserved Gene / Pathway	Phase 2: March 2008	1GHH	30.5%	Yersinia pestis	Cellular processes	Pathogenesis

IDP01765 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5716	47531053	purA	adenylosuccinate synthetase [Bacillus an...	429	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GIM	47.1%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01218 (show subtarget assignments)	1	expressed	No	BA_3712	73919984		Histidine ammonia-lyase (Histidase)	505	Drug Target Function	Phase 2: March 2008	1GK2	42%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP00569 (show subtarget assignments)	1	purified	No	YPO4016	16124139	hutH	histidine ammonia-lyase	510	Drug Target Function	Phase 2: March 2008	1GK2	77.5%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04554 (show subtarget assignments)	1	cloned	No	STM0791_1_506	16764154	hutH	histidine ammonia-lyase [Salmonella typh...	506	Salmonella essential protein	Phase 4: April 2009	1GK2	76.5%	Salmonella enterica

IDP04249 (show subtarget assignments)	1	expressed	No	CPF_1548	110800969		putative galactoside ABC transporter, ga...	354	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GLG	50.6%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP05649 (show subtarget assignments)	1	expressed	No	Cj0464	6967934	recG	zinc protease-like protein [Campylobacte...	607	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GM5	28.8%	Campylobacter jejuni	DNA metabolism: DNA replication, recombination, and repair

IDP05559 (show subtarget assignments)	1	soluble	No	lmo1811	16803851	-	hypothetical protein lmo1811 [Listeria m...	697	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GM5	40.3%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05040 (show subtarget assignments)	1	expressed	No	BA_2262	30256905		heat shock protein, Hsp20 family [Bacill...	145	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1GME	30.3%	Bacillus anthracis	Cellular processes: Adaptations to atypical conditions

IDP90674 (show subtarget assignments)	8	cloned	No	Cj0542	15791903	hemA	glutamyl-tRNA reductase [Campylobacter j...	432	Predicted Essential	Community Requests	1GPJ	27.3%	Campylobacter jejuni

IDP02291 (show subtarget assignments)	1	cloned	No	FTT0167	56707337	hemA	glutamyl-tRNA reductase [Francisella tul...	416	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	26.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90936 (show subtarget assignments)	8	cloned	No	YPO2016	16122259	hemA	glutamyl-tRNA reductase [Yersinia pestis...	420	Predicted Essential	Community Requests	1GPJ	32.9%	Yersinia pestis

IDP91454 (show subtarget assignments)	8	cloned	No	VV1_0254	27363735	hemA	glutamyl-tRNA reductase [Vibrio vulnific...	419	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1GPJ	36.3%	Vibrio vulnificus

IDP04169 (show subtarget assignments)	1	in_crystallization_trials	No	VC2180	15642179	hemA	glutamyl-tRNA reductase [Vibrio cholerae...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GPJ	35.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02522 (show subtarget assignments)	1	expressed	No	CBU_1966	29542521	hemA	glutamyl-tRNA reductase [Coxiella burnet...	413	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	30.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02777 (show subtarget assignments)	1	soluble	No	GBAA4698	47529997	hemA	glutamyl-tRNA reductase [Bacillus anthra...	444	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	27.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90256 (show subtarget assignments)	8	crystallized	No	SAR0409	49482642	guaA	bifunctional GMP synthase/glutamine amid...	513	(From requestor) Identified potential S. aureus drug target. Would like to devel...	Community Requests	1GPM	51.2%	Staphylococcus aureus

IDP04199 (show subtarget assignments)	1	cloned	No	CPF_2557	110800712	guaA	bifunctional GMP synthase/glutamine amid...	509	conserved gene; putative drug target function;	Phase 4: April 2009	1GPM	52.3%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02219 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1019c	56708108	guaA	bifunctional GMP synthase/glutamine amid...	516	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1GPM	61.1%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90695 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1248	15792572	guaA	bifunctional GMP synthase/glutamine amid...	511	Predicted Essential	Community Requests	1GPM	51.8%	Campylobacter jejuni

IDP04497 (show subtarget assignments)	1	soluble	No	VC0768	9655215		GMP synthase [Vibrio cholerae O1 biovar ...	517	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GPM	80.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90275 (show subtarget assignments)	8	soluble	No	TGME49_030450	211965620		GMP synthase, putative [Toxoplasma gondi...	569	Guanosine monophosphate synthetase is essential for the synthesis of GMP in puri...	Community Requests	1GPM	51%	Toxoplasma gondii

IDP04478 (show subtarget assignments)	1	soluble	No	YPO2870	115348541	guaA	putative GMP synthase [Yersinia pestis C...	525	drug target; putative drug target function;	Phase 4: April 2009	1GPM	87.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02560 (show subtarget assignments)	1	cloned	No	GBAA0268	47777798	guaA	bifunctional GMP synthase/glutamine amid...	512	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GPM	52.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00433 (show subtarget assignments)	1	purified	No	YPO1545	16121818	hisH	imidazole glycerol phosphate synthase su...	196	Drug Target Function	Phase 2: March 2008	1GPW	35.3%	Yersinia pestis	Amino acid biosynthesis	Histidine family

IDP01844 (show subtarget assignments)	1	soluble	No	GBAA1428	47526700	hisH	imidazole glycerol phosphate synthase su...	209	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GPW	35.9%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP02047 (show subtarget assignments)	0	work_stopped	No	STM3041c	39546356	prfB	peptide chain release factor 2 [Salmonel...	358	Essential; Drug target functions	Phase 3: June 2008	1GQE	91.9%	Salmonella enterica	N/A	N/A

IDP02836 (show subtarget assignments)	1	crystallized	No	GBAA4423	47529716	aroQ	3-dehydroquinate dehydratase [Bacillus a...	146	Conserved; Drug target functions	Phase 3: June 2008	1GQO	57.5%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02000 (show subtarget assignments)	1	cloned	No	YPO0008	16120361	rbsK	ribokinase [Yersinia pestis CO92]	308	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1GQT	70.5%	Yersinia pestis	Energy metabolism	Pentose phosphate pathway

IDP02172
(show subtarget assignments)

1

cloned

No

YPO0893

16121198

fldB

flavodoxin FldB [Yersinia pestis CO92]

172

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1FLV

46.5%

Yersinia pestis

Energy metabolism

Electron transport

IDP04099
(show subtarget assignments)

1

expressed

No

VC1027

9655490

molybdenum cofactor biosynthesis protein...

81

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1FM0

70.4%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP92121
(show subtarget assignments)

8

selected

No

ADC80547

289064343

methionyl-tRNA formyltransferase [Toxopl...

885

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1FMT

10.3%

Toxoplasma gondii

IDP04083
(show subtarget assignments)

1

cloned

No

YPO1631

218928767

pepT

peptidase T [Yersinia pestis CO92]

411

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1FNO

76.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01063
(show subtarget assignments)

1

soluble

No

STM3702

16766987

grxC

glutaredoxin 3

83

Conserved Gene / Pathway

Phase 2: March 2008

1FOV

86.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP05343
(show subtarget assignments)

1

soluble

No

Z1544

12514412

putative acyl-carrier protein synthase [...

122

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1FTE

36.1%

Escherichia coli

Fatty acid and phospholipid metabolism: Biosynthesis

IDP01626
(show subtarget assignments)

1

cloned

No

GBAA5017

47530320

metK

S-adenosylmethionine synthetase [Bacillu...

399

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FUG

62.4%

Bacillus anthracis

Central intermediary metabolism

Other

IDP90798
(show subtarget assignments)

8

in_crystallization_trials

No

VC0472

15640499

S-adenosylmethionine synthetase [Vibrio ...

385

Predicted Essential

Community Requests

1FUG

87.5%

Vibrio cholerae

IDP00748
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1837

57284761

metK

S-adenosylmethionine synthetase

397

Drug Target Function

Phase 2: March 2008

1FUG

62.2%

Staphylococcus aureus

Central intermediary metabolism

One-carbon metabolism

IDP04492
(show subtarget assignments)

1

cloned

No

YPO3834

218930837

pldA

phospholipase A [Yersinia pestis CO92]

292

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1FW2

69.2%

Yersinia pestis

Fatty acid and phospholipid metabolism

Degradation

IDP90584
(show subtarget assignments)

8

purified

No

VC0095

15640127

chorismate--pyruvate lyase [Vibrio chole...

183

Predicted Essential

Community Requests

1FW9

28.4%

Vibrio cholerae

IDP90656
(show subtarget assignments)

8

purified

No

Cj0384c

15791751

kdsA

2-dehydro-3-deoxyphosphooctonate aldolas...

271

Predicted Essential

Community Requests

1FWN

55.7%

Campylobacter jejuni

IDP90144
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_189.5

68449261

bifunctional IL-1-beta-inhibitor/prevent...

126

contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184

Community Requests

1G0Y

27.8%

Monkeypox virus

IDP02012
(show subtarget assignments)

1

soluble

No

STM4233

16767483

ubiC

chorismate pyruvate lyase [Salmonella ty...

165

Conserved; Drug target functions

Phase 3: June 2008

1G1B

86.1%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP90522
(show subtarget assignments)

8

in_crystallization_trials

No

YPO0310

16120648

ubiC

chorismate pyruvate lyase [Yersinia pest...

174

Predicted Essential

Community Requests

1G1B

50.6%

Yersinia pestis

IDP02114
(show subtarget assignments)

1

purified

No

FTT0688c

56707808

hslV

ATP-dependent protease peptidase subunit...

183

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1G3I

59.6%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP00672
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1271

57286009

hslU

ATP-dependent protease ATP-binding subun...

467

Drug Target Function

Phase 2: March 2008

1G3I

47.1%

Staphylococcus aureus

Protein fate

Protein folding and stabilization

IDP01450
(show subtarget assignments)

1

in_crystallization_trials

No

VC2269

15642267

3,4-dihydroxy-2-butanone 4-phosphate syn...

369

Drug Target Function

Phase 2: March 2008

1G57

30.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00332
(show subtarget assignments)

1

purified

No

FTT1673

56708683

ribA

riboflavin biosynthesis protein ribA/GTP...

403

Drug Target Function

Phase 2: March 2008

1G57

27%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02798
(show subtarget assignments)

1

purified

No

GBAA5049

47530348

carbonic anhydrase [Bacillus anthracis s...

187

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1G5C

34.8%

Bacillus anthracis

Central intermediary metabolism

Other

IDP90845
(show subtarget assignments)

8

selected

No

S1357

30062792

btuR

cob(I)yrinic acid a,c-diamide adenosyltr...

196

Predicted Essential

Community Requests

1G5R

88.3%

Shigella flexneri

IDP90638
(show subtarget assignments)

8

soluble

No

VC1040

15641053

cob(I)yrinic acid a,c-diamide adenosyltr...

201

Predicted Essential

Community Requests

1G5R

64.2%

Vibrio cholerae

IDP04469
(show subtarget assignments)

1

cloned

No

YPO2214

115347921

btuR

cob(I)alamin adenosyltransferase [Yersin...

196

conserved gene; putative drug target function;

Phase 4: April 2009

1G5R

78.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP91355
(show subtarget assignments)

8

soluble

No

VV1_3022

27366292

cob(I)yrinic acid a,c-diamide adenosyltr...

211

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1G5R

59.2%

Vibrio vulnificus

IDP01352
(show subtarget assignments)

1

soluble

No

VCA0447

15601210

haemagglutinin associated protein

230

Conserved Gene / Pathway

Phase 2: March 2008

1G60

29.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01121
(show subtarget assignments)

1

expressed

No

BA_1933

30256591

branched-chain amino acid ABC transporte...

257

Conserved Gene / Pathway

Phase 2: March 2008

1G6H

31.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP91810
(show subtarget assignments)

8

soluble

No

b3357

1789756

crp

DNA-binding transcriptional dual regulat...

210

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1G6N

100%

Escherichia coli

IDP00946
(show subtarget assignments)

1

expressed

No

STM0978

16764338

aroA

3-phosphoshikimate 1-carboxyvinyltransfe...

427

Conserved Gene / Pathway

Phase 2: March 2008

1G6S

89.5%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP90726
(show subtarget assignments)

8

purified

No

YPO1390

16121670

aroA

3-phosphoshikimate 1-carboxyvinyltransfe...

428

Predicted Essential

Community Requests

1G6S

80.1%

Yersinia pestis

IDP92116
(show subtarget assignments)

8

selected

No

TGME49_060680

237831887

DNA primase small subunit, putative [Tox...

509

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1G71

9.2%

Toxoplasma gondii

IDP04471
(show subtarget assignments)

1

purified

No

YPO2370

218929461

pdxH

pyridoxamine 5'-phosphate oxidase [Yersi...

217

conserved gene; putative drug target function;

Phase 4: April 2009

1G76

78.4%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP04507
(show subtarget assignments)

1

crystallized

No

VCA1079

9658525

pyridoxamine 5`-phosphate oxidase [Vibri...

211

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1G76

65.9%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP00884
(show subtarget assignments)

1

purified

No

STM1925

16765267

flhD

transcriptional activator FlhD

116

Conserved Gene / Pathway

Phase 2: March 2008

1G8E

89.7%

Salmonella enterica

Cell envelope

Surface structures

IDP01179
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0048

81583548

Bifunctional protein glmU [Includes: UDP...

459

Drug Target Function

Phase 2: March 2008

1G95

51.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00656
(show subtarget assignments)

1

cloned

No

SACOL0543

57284226

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

450

Drug Target Function

Phase 2: March 2008

1G95

49.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91618
(show subtarget assignments)

8

expressed

No

BAB36097

13362142

ECs2674

hypothetical protein [Escherichia coli O...

379

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1G9U

13.7%

Escherichia coli

IDP91619
(show subtarget assignments)

8

soluble

No

BAB36095

13362140

ECs2672

hypothetical protein [Escherichia coli O...

379

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1G9U

13.5%

Escherichia coli

IDP05568
(show subtarget assignments)

1

cloned

No

S4492

30043719

valS

valine tRNA synthetase [Shigella flexner...

951

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GAX

39.9%

Shigella flexneri

Protein synthesis: tRNA aminoacylation

IDP05758
(show subtarget assignments)

1

cloned

No

lmo1552

16803592

valS

valyl-tRNA synthetase [Listeria monocyto...

883

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GAX

40%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP04005
(show subtarget assignments)

1

purified

No

BAS4355

49187350

valyl-tRNA synthetase [Bacillus anthraci...

881

Proposed to be essential proteins

Phase 4: April 2009

1GAX

42.6%

Bacillus anthracis

IDP05578
(show subtarget assignments)

1

cloned

No

SACOL1710

57650536

valS

valyl-tRNA synthetase [Staphylococcus au...

876

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GAX

40.2%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP90658
(show subtarget assignments)

8

cloned

No

VC2503

15642499

valS

valyl-tRNA synthetase [Vibrio cholerae O...

953

Predicted Essential

Community Requests

1GAX

38.8%

Vibrio cholerae

IDP92132
(show subtarget assignments)

8

selected

No

TGME49_053290

237840177

valyl-tRNA synthetase, putative [Toxopla...

1042

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1GAX

35.3%

Toxoplasma gondii

IDP90598
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3443

16123591

valS

valyl-tRNA synthetase [Yersinia pestis C...

965

Predicted Essential

Community Requests

1GAX

40.5%

Yersinia pestis

IDP05749
(show subtarget assignments)

1

cloned

No

Cj0775c

6968216

valS

putative periplasmic protein [Campylobac...

870

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GAX

38.2%

Campylobacter jejuni

Protein synthesis: tRNA aminoacylation

IDP92102
(show subtarget assignments)

8

selected

No

TGME49_069110

237832613

ornithine aminotransferase, putative [To...

441

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1GBN

47.2%

Toxoplasma gondii

IDP00587
(show subtarget assignments)

1

cloned

No

YPO1507

16121780

mglB

galactose-binding protein

335

Virulence Associated Factor

Phase 2: March 2008

1GCA

80.9%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01639
(show subtarget assignments)

1

cloned

No

GBAA4225

47529518

aminotransferase A [Bacillus anthracis s...

387

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1GD9

39.5%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01606
(show subtarget assignments)

1

cloned

No

GBAA4968

47530266

gdH

glucose-1-dehydrogenase [Bacillus anthra...

261

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GEE

87.7%

Bacillus anthracis

Energy metabolism

Other

IDP02610
(show subtarget assignments)

1

expressed

No

Cj1417c

15792735

hypothetical protein Cj1417c [Campylobac...

200

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1GEE

87.7%

Campylobacter jejuni

Cell envelope

Other

IDP02152
(show subtarget assignments)

1

soluble

No

FTT0955c

56708049

gor

glutathione reductase [Francisella tular...

453

Conserved; Drug target functions

Phase 3: June 2008

1GER

49.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP92095
(show subtarget assignments)

8

selected

No

TGME49_046920

237835543

glutathione reductase, putative [Toxopla...

483

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1GER

46.2%

Toxoplasma gondii

IDP91210
(show subtarget assignments)

8

expressed

No

BLIJ_0364

189439941

aroG2

phospho-2-dehydro-3-deoxyheptonate aldol...

377

potential drug target / Shikimate pathway enzyme

Community Requests

1GG1

47.7%

Bifidobacterium longum

IDP91163
(show subtarget assignments)

8

cloned

No

VC1507

15641516

phospho-2-dehydro-3-deoxyheptonate aldol...

395

potential drug target / Shikimate pathway enzyme

Community Requests

1GG1

48.9%

Vibrio cholerae

IDP01013
(show subtarget assignments)

1

purified

No

STM2670

16765985

aroF

phospho-2-dehydro-3-deoxyheptonate aldol...

356

Conserved Gene / Pathway

Phase 2: March 2008

1GG1

51.4%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP91164
(show subtarget assignments)

8

purified

No

VC0695

15640714

phospho-2-dehydro-3-deoxyheptonate aldol...

357

potential drug target / Shikimate pathway enzyme

Community Requests

1GG1

50.7%

Vibrio cholerae

IDP90850
(show subtarget assignments)

8

soluble

No

YPO0551

16120879

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

458

Predicted Essential

Community Requests

1GG4

69.9%

Yersinia pestis

IDP05742
(show subtarget assignments)

1

cloned

No

CD2655

126700269

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

457

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1GG4

31.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02368
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0422

56707569

murF

UDP-N--acetylmuramoylalanyl-D-glutamyl-2...

452

Conserved; Drug target functions

Phase 3: June 2008

1GG4

33.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01455
(show subtarget assignments)

1

purified

No

VC2405

15642402

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

453

Conserved Gene / Pathway

Phase 2: March 2008

1GG4

52.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02731
(show subtarget assignments)

1

expressed

No

CBU_0124

29540744

murF

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

446

Conserved; Drug target functions

Phase 3: June 2008

1GG4

43.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00904
(show subtarget assignments)

0

work_stopped

No

STM0124

16763514

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

452

Conserved Gene / Pathway

Phase 2: March 2008

1GG4

87.6%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91966
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100001092

298254195

ABC transporter substrate-binding protei...

271

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1GGG

28.4%

Streptococcus pneumoniae

IDP01356
(show subtarget assignments)

1

soluble

No

VC0010

15640042

amino acid ABC transporter, periplasmic ...

248

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

31.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP91402
(show subtarget assignments)

8

purified

No

VV1_1001

27364435

ABC-type amino acid transport, signal tr...

250

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1GGG

31.2%

Vibrio vulnificus

IDP00474
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2512

16122733

glnH

glutamine ABC transporter periplasmic pr...

247

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

78.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01317
(show subtarget assignments)

1

soluble

No

VC0966

15640982

phosphocarrier protein HPr

85

Conserved Gene / Pathway

Phase 2: March 2008

1GGR

75.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00719
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1457

57284566

PTS system, IIA component

166

Conserved Gene / Pathway

Phase 2: March 2008

1GGR

41%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP91826
(show subtarget assignments)

8

expressed

No

b2415

1788755

ptsH

phosphohistidinoprotein-hexose phosphotr...

85

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1GGR

100%

Escherichia coli

IDP01237
(show subtarget assignments)

1

purified

No

BA_5563

46396830

Glucose-specific phosphotransferase enzy...

165

Drug Target Function

Phase 2: March 2008

1GGR

46.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01855
(show subtarget assignments)

1

soluble

No

STM1162

16764518

dinI

DNA damage-inducible protein I [Salmonel...

81

Conserved; Drug target functions

Phase 3: June 2008

1GHH

85.2%

Salmonella enterica

Unknown function

General

IDP00593
(show subtarget assignments)

1

expressed

No

YPO1232

16121518

msgA

putative stress response protein

80

Conserved Gene / Pathway

Phase 2: March 2008

1GHH

30.5%

Yersinia pestis

Cellular processes

Pathogenesis

IDP01765
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5716

47531053

purA

adenylosuccinate synthetase [Bacillus an...

429

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GIM

47.1%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01218
(show subtarget assignments)

1

expressed

No

BA_3712

73919984

Histidine ammonia-lyase (Histidase)

505

Drug Target Function

Phase 2: March 2008

1GK2

42%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP00569
(show subtarget assignments)

1

purified

No

YPO4016

16124139

hutH

histidine ammonia-lyase

510

Drug Target Function

Phase 2: March 2008

1GK2

77.5%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04554
(show subtarget assignments)

1

cloned

No

STM0791_1_506

16764154

hutH

histidine ammonia-lyase [Salmonella typh...

506

Salmonella essential protein

Phase 4: April 2009

1GK2

76.5%

Salmonella enterica

IDP04249
(show subtarget assignments)

1

expressed

No

CPF_1548

110800969

putative galactoside ABC transporter, ga...

354

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GLG

50.6%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP05649
(show subtarget assignments)

1

expressed

No

Cj0464

6967934

recG

zinc protease-like protein [Campylobacte...

607

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GM5

28.8%

Campylobacter jejuni

DNA metabolism: DNA replication, recombination, and repair

IDP05559
(show subtarget assignments)

1

soluble

No

lmo1811

16803851

-

hypothetical protein lmo1811 [Listeria m...

697

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GM5

40.3%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05040
(show subtarget assignments)

1

expressed

No

BA_2262

30256905

heat shock protein, Hsp20 family [Bacill...

145

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1GME

30.3%

Bacillus anthracis

Cellular processes: Adaptations to atypical conditions

IDP90674
(show subtarget assignments)

8

cloned

No

Cj0542

15791903

hemA

glutamyl-tRNA reductase [Campylobacter j...

432

Predicted Essential

Community Requests

1GPJ

27.3%

Campylobacter jejuni

IDP02291
(show subtarget assignments)

1

cloned

No

FTT0167

56707337

hemA

glutamyl-tRNA reductase [Francisella tul...

416

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

26.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90936
(show subtarget assignments)

8

cloned

No

YPO2016

16122259

hemA

glutamyl-tRNA reductase [Yersinia pestis...

420

Predicted Essential

Community Requests

1GPJ

32.9%

Yersinia pestis

IDP91454
(show subtarget assignments)

8

cloned

No

VV1_0254

27363735

hemA

glutamyl-tRNA reductase [Vibrio vulnific...

419

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1GPJ

36.3%

Vibrio vulnificus

IDP04169
(show subtarget assignments)

1

in_crystallization_trials

No

VC2180

15642179

hemA

glutamyl-tRNA reductase [Vibrio cholerae...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GPJ

35.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02522
(show subtarget assignments)

1

expressed

No

CBU_1966

29542521

hemA

glutamyl-tRNA reductase [Coxiella burnet...

413

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

30.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02777
(show subtarget assignments)

1

soluble

No

GBAA4698

47529997

hemA

glutamyl-tRNA reductase [Bacillus anthra...

444

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

27.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90256
(show subtarget assignments)

8

crystallized

No

SAR0409

49482642

guaA

bifunctional GMP synthase/glutamine amid...

513

(From requestor) Identified potential S. aureus drug target. Would like to devel...

Community Requests

1GPM

51.2%

Staphylococcus aureus

IDP04199
(show subtarget assignments)

1

cloned

No

CPF_2557

110800712

guaA

bifunctional GMP synthase/glutamine amid...

509

conserved gene; putative drug target function;

Phase 4: April 2009

1GPM

52.3%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02219
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1019c

56708108

guaA

bifunctional GMP synthase/glutamine amid...

516

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1GPM

61.1%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90695
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1248

15792572

guaA

bifunctional GMP synthase/glutamine amid...

511

Predicted Essential

Community Requests

1GPM

51.8%

Campylobacter jejuni

IDP04497
(show subtarget assignments)

1

soluble

No

VC0768

9655215

GMP synthase [Vibrio cholerae O1 biovar ...

517

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GPM

80.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90275
(show subtarget assignments)

8

soluble

No

TGME49_030450

211965620

GMP synthase, putative [Toxoplasma gondi...

569

Guanosine monophosphate synthetase is essential for the synthesis of GMP in puri...

Community Requests

1GPM

51%

Toxoplasma gondii

IDP04478
(show subtarget assignments)

1

soluble

No

YPO2870

115348541

guaA

putative GMP synthase [Yersinia pestis C...

525

drug target; putative drug target function;

Phase 4: April 2009

1GPM

87.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02560
(show subtarget assignments)

1

cloned

No

GBAA0268

47777798

guaA

bifunctional GMP synthase/glutamine amid...

512

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GPM

52.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00433
(show subtarget assignments)

1

purified

No

YPO1545

16121818

hisH

imidazole glycerol phosphate synthase su...

196

Drug Target Function

Phase 2: March 2008

1GPW

35.3%

Yersinia pestis

Amino acid biosynthesis

Histidine family

IDP01844
(show subtarget assignments)

1

soluble

No

GBAA1428

47526700

hisH

imidazole glycerol phosphate synthase su...

209

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GPW

35.9%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP02047
(show subtarget assignments)

0

work_stopped

No

STM3041c

39546356

prfB

peptide chain release factor 2 [Salmonel...

358

Essential; Drug target functions

Phase 3: June 2008

1GQE

91.9%

Salmonella enterica

N/A

IDP02836
(show subtarget assignments)

1

crystallized

No

GBAA4423

47529716

aroQ

3-dehydroquinate dehydratase [Bacillus a...

146

Conserved; Drug target functions

Phase 3: June 2008

1GQO

57.5%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02000
(show subtarget assignments)

1

cloned

No

YPO0008

16120361

rbsK

ribokinase [Yersinia pestis CO92]

308

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1GQT

70.5%

Yersinia pestis

Energy metabolism

Pentose phosphate pathway