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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 6 of 60, showing 100 records out of 5973 total, starting on record 501
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP04350
(
show subtarget assignments
)
1
cloned
No
STM1338_1_795
16764689
pheT
phenylalanyl-tRNA synthetase subunit bet...
795
Salmonella essential protein
Phase 4: April 2009
3PCO
92.6%
Salmonella enterica
IDP05216
(
show subtarget assignments
)
1
cloned
No
CD3349
126700969
bclA3
putative exosporium glycoprotein [Clostr...
657
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3HQV
35.6%
Clostridium difficile
Unknown function: General
IDP04046
(
show subtarget assignments
)
1
cloned
No
YPCD1.78c
16082765
tap
repA translation protein [Yersinia pesti...
24
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04612
(
show subtarget assignments
)
1
cloned
No
BAS3764
49186763
phospho-N-acetylmuramoyl-pentapeptide-tr...
324
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP04577
(
show subtarget assignments
)
1
cloned
No
BAS0087
49183121
glutamyl-tRNA synthetase [Bacillus anthr...
485
Proposed to be essential proteins
Phase 4: April 2009
2O5R
44.4%
Bacillus anthracis
IDP04578
(
show subtarget assignments
)
1
cloned
No
BAS0089
49183123
cysteinyl-tRNA synthetase [Bacillus anth...
465
Proposed to be essential proteins
Phase 4: April 2009
1LI5
45.6%
Bacillus anthracis
IDP05020
(
show subtarget assignments
)
1
soluble
No
CD1027
126698611
potD
spermidine/putrescine ABC transporter,su...
350
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
4EQB
39.1%
Clostridium difficile
Transport and binding proteins: Amino acids, peptides and amines
IDP05221
(
show subtarget assignments
)
1
expressed
No
BA_4349
30258849
hypothetical protein BA_4349 [Bacillus a...
62
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04613
(
show subtarget assignments
)
1
cloned
No
BAS3890
49186888
M20/M25/M40 family peptidase [Bacillus a...
376
Proposed to be essential proteins
Phase 4: April 2009
1YSJ
35.6%
Bacillus anthracis
IDP04349
(
show subtarget assignments
)
1
expressed
No
STM0557_1_550
16763935
putative inner membrane protein [Salmone...
550
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04616
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS4313
49187308
S-adenosylmethionine:tRNA ribosyltransfe...
350
Proposed to be essential proteins
Phase 4: April 2009
1YY3
71.4%
Bacillus anthracis
IDP04276
(
show subtarget assignments
)
1
soluble
No
FTT0312c
56707465
folA
dihydrofolate reductase type I [Francise...
166
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3JW3
41.6%
Francisella tularensis
IDP05077
(
show subtarget assignments
)
1
cloned
No
lmo1115
16803155
-
hypothetical protein lmo1115 [Listeria m...
873
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
Unclassified: Role category not yet assigned
IDP05037
(
show subtarget assignments
)
1
soluble
No
BA_1836
30256106
putative polysaccharide deacetylase [Bac...
234
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2C71
27.4%
Bacillus anthracis
Energy metabolism: Biosynthesis and degradation of polysaccharides
IDP05101
(
show subtarget assignments
)
1
in_crystallization_trials
No
CD1058
126698642
hbd
3-hydroxybutyryl-CoA dehydrogenase [Clos...
281
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1F0Y
43.9%
Clostridium difficile
Fatty acid and phospholipid metabolism: Degradation
IDP04380
(
show subtarget assignments
)
1
cloned
No
STM3713_1_404
16766998
rfaL
O-antigen ligase [Salmonella typhimurium...
404
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05098
(
show subtarget assignments
)
1
purified
No
CD0569
126698147
putative outer membrane lipoprotein [Clo...
334
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2FQW
21.3%
Clostridium difficile
Cell envelope: Other
IDP05130
(
show subtarget assignments
)
1
cloned
No
CD0119
126697691
phosphoglucomutase/phosphomannomutase mu...
454
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3PDK
50.2%
Clostridium difficile
Central intermediary metabolism: Amino sugars
IDP04587
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0118
49183152
50S ribosomal protein L29 [Bacillus anth...
66
Proposed to be essential proteins
Phase 4: April 2009
1R73
45.5%
Bacillus anthracis
IDP04621
(
show subtarget assignments
)
1
cloned
No
BAS4494
49187489
acetyl-CoA carboxylase carboxyltransfera...
324
Proposed to be essential proteins
Phase 4: April 2009
2F9I
60.2%
Bacillus anthracis
IDP04308
(
show subtarget assignments
)
1
cloned
No
YPCD1.14n
40548797
hypothetical protein YPCD1.14n [Yersinia...
65
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04606
(
show subtarget assignments
)
1
cloned
No
BAS3692
49186691
tRNA (guanine-N(1)-)-methyltransferase [...
244
Proposed to be essential proteins
Phase 4: April 2009
3KY7
62.3%
Bacillus anthracis
IDP04728
(
show subtarget assignments
)
1
selected
No
BAS0102
49183136
DNA-directed RNA polymerase subunit beta...
1177
Proposed to be essential proteins
Phase 4: April 2009
1HQM
49.2%
Bacillus anthracis
IDP04601
(
show subtarget assignments
)
1
in_pdb
3RHI
Yes
BAS3574
49186575
DNA-binding protein HU [Bacillus anthrac...
90
Proposed to be essential proteins
Phase 4: April 2009
3RHI
100%
Bacillus anthracis
IDP04217
(
show subtarget assignments
)
1
cloned
No
STM2619_1_203
16765939
hypothetical protein STM2619 [Salmonella...
203
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04627
(
show subtarget assignments
)
8
cloned
No
BAS5321
49188305
replicative DNA helicase [Bacillus anthr...
453
Proposed to be essential proteins
Community Requests
2VYE
75.3%
Bacillus anthracis
IDP04618
(
show subtarget assignments
)
1
cloned
No
BAS4456
49187451
phenylalanyl-tRNA synthetase subunit alp...
344
Proposed to be essential proteins
Phase 4: April 2009
2RHQ
57.6%
Bacillus anthracis
IDP05058
(
show subtarget assignments
)
1
in_crystallization_trials
No
CD0468
126698044
malL
oligo-1,6-glucosidase [Clostridium diffi...
554
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2ZE0
44%
Clostridium difficile
Energy metabolism: Sugars
IDP05033
(
show subtarget assignments
)
1
cloned
No
BA_1260
30255209
hypothetical protein BA_1260 [Bacillus a...
34
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04620
(
show subtarget assignments
)
1
cloned
No
BAS4482
49187477
DNA polymerase I [Bacillus anthracis str...
891
Proposed to be essential proteins
Phase 4: April 2009
3TAN
45%
Bacillus anthracis
IDP04306
(
show subtarget assignments
)
8
selected
No
CAC05809
12329078
ipgE
IpgE, cytoplasmic chaperone for IpgD [Sh...
120
Shigella effector protein
Community Requests
1K3S
27.5%
Shigella flexneri
IDP05117
(
show subtarget assignments
)
1
cloned
No
CD2831
126700447
putative collagen-binding protein [Clost...
972
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3KPT
9.3%
Clostridium difficile
Unknown function: General
IDP05111
(
show subtarget assignments
)
1
cloned
No
CD2187
126699803
putative phage-related cell wall hydrola...
297
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3FI7
21.2%
Clostridium difficile
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP04619
(
show subtarget assignments
)
1
in_pdb
4DIB
No
BAS4478
49187473
glyceraldehyde-3-phosphate dehydrogenase...
342
Proposed to be essential proteins
Phase 4: April 2009
4DIB
100%
Bacillus anthracis
IDP05042
(
show subtarget assignments
)
1
soluble
No
BA_2921
30257513
putative sulfonate ABC transporter, sulf...
328
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2X26
28%
Bacillus anthracis
Transport and binding proteins: Anions
IDP04064
(
show subtarget assignments
)
1
expressed
No
BAS0127
49183161
30S ribosomal protein S5 [Bacillus anthr...
166
Proposed to be essential proteins
Phase 4: April 2009
1PKP
75.3%
Bacillus anthracis
IDP05113
(
show subtarget assignments
)
1
in_pdb
4EGU
No
CD2447
126700064
histidine triad nucleotide-binding prote...
119
virulence/pathogenesis /
Targets associated with virulence and/or pathogenesis
Phase 5: 2010
4EGU
100%
Clostridium difficile
Unknown function: General
IDP05112
(
show subtarget assignments
)
1
cloned
No
CD2246
126699864
cspC
putative germination-specific protease [...
557
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3EIF
22.3%
Clostridium difficile
Unknown function: General
IDP05115
(
show subtarget assignments
)
1
cloned
No
CD2567
126700186
PTS system, IIB component [Clostridium d...
102
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2R48
43.1%
Clostridium difficile
Signal transduction: PTS
IDP04636
(
show subtarget assignments
)
1
soluble
No
FTT0238
56707395
aroE1
shikimate 5-dehydrogenase [Francisella t...
257
drug target; conserved gene;
Phase 4: April 2009
3O8Q
36.8%
Francisella tularensis
IDP04605
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS3689
49186688
ribosomal biogenesis GTPase [Bacillus an...
296
Proposed to be essential proteins
Phase 4: April 2009
1PUJ
67.2%
Bacillus anthracis
IDP04015
(
show subtarget assignments
)
1
purified
No
VC0395
15640422
UTP--glucose-1-phosphate uridylyltransfe...
291
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3JUJ
58.1%
Vibrio cholerae
Purines, pyrimidines, nucleosides, and nucleotides
IDP04597
(
show subtarget assignments
)
1
expressed
No
BAS1384
49184401
resB protein [Bacillus anthracis str. St...
541
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP04731
(
show subtarget assignments
)
1
crystallized
No
BAS3675
49186674
ribosome recycling factor [Bacillus anth...
185
Proposed to be essential proteins
Phase 4: April 2009
1IS1
50.8%
Bacillus anthracis
IDP04089
(
show subtarget assignments
)
1
expressed
No
STM1952_1_222
16765290
yecS
putative ABC-type amino acid transporter...
222
Salmonella essential protein
Phase 4: April 2009
2R6G
24.3%
Salmonella enterica
IDP05076
(
show subtarget assignments
)
1
soluble
No
lmo0801
16802843
-
hypothetical protein lmo0801 [Listeria m...
646
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1M9S
22.1%
Listeria monocytogenes
Cellular processes: Pathogenesis
IDP04216
(
show subtarget assignments
)
1
cloned
No
STM1894_1_336
16765236
ruvB
Holliday junction DNA helicase B [Salmon...
336
Salmonella essential protein
Phase 4: April 2009
1HQC
53%
Salmonella enterica
IDP04310
(
show subtarget assignments
)
1
cloned
No
BAS0231
49183264
D-alanine--D-alanine ligase, C-terminus ...
91
Proposed to be essential proteins
Phase 4: April 2009
2I80
54.9%
Bacillus anthracis
IDP04219
(
show subtarget assignments
)
1
cloned
No
STM3148_1_392
16766448
hybB
putative hydrogenase 2 b cytochrome subu...
392
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05119
(
show subtarget assignments
)
1
soluble
No
CD2989
126700610
ABC transporter, substrate-binding prote...
319
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2X7P
23.5%
Clostridium difficile
Transport and binding proteins: Unknown substrate
IDP04383
(
show subtarget assignments
)
1
purified
No
BAS4455
49187450
phenylalanyl-tRNA synthetase subunit bet...
806
Proposed to be essential proteins
Phase 4: April 2009
2RHS
49.8%
Bacillus anthracis
IDP04623
(
show subtarget assignments
)
1
expressed
No
BAS4760
49187751
glucose-1-phosphate adenylyltransferase ...
376
Proposed to be essential proteins
Phase 4: April 2009
3BRK
40%
Bacillus anthracis
IDP04309
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0050
49183085
peptidyl-tRNA hydrolase [Bacillus anthra...
186
Proposed to be essential proteins
Phase 4: April 2009
3KJZ
40.9%
Bacillus anthracis
IDP04381
(
show subtarget assignments
)
8
selected
No
CAC05791
12329060
unnamed protein product [Shigella flexne...
296
Shigella effector protein
Community Requests
3MKL
8.4%
Shigella flexneri
IDP04622
(
show subtarget assignments
)
1
soluble
No
BAS4556
49187550
tyrosyl-tRNA synthetase [Bacillus anthra...
418
potential drug target /
Proposed to be essential proteins
Phase 4: April 2009
2TS1
70.6%
Bacillus anthracis
IDP04098
(
show subtarget assignments
)
1
cloned
No
YPCD1.50
5832470
YPCD1.50
hypothetical protein YPCD1.50 [Yersinia ...
32
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04600
(
show subtarget assignments
)
1
cloned
No
BAS2547
49185555
preprotein translocase subunit SecY [Bac...
434
Proposed to be essential proteins
Phase 4: April 2009
3DIN
42.2%
Bacillus anthracis
IDP05050
(
show subtarget assignments
)
1
purified
No
BA_5330
30259806
iron compound ABC transporter, iron comp...
333
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3GFV
26.4%
Bacillus anthracis
Transport and binding proteins: Cations and iron carrying compounds
IDP05040
(
show subtarget assignments
)
1
expressed
No
BA_2262
30256905
heat shock protein, Hsp20 family [Bacill...
145
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1GME
30.3%
Bacillus anthracis
Cellular processes: Adaptations to atypical conditions
IDP04599
(
show subtarget assignments
)
1
cloned
No
BAS2268
49185277
aspartate-semialdehyde dehydrogenase [Ba...
347
Proposed to be essential proteins
Phase 4: April 2009
2GYY
55.3%
Bacillus anthracis
IDP04115
(
show subtarget assignments
)
1
expressed
No
STM2352_1_235
16765679
hisM
histidine/lysine/arginine/ornithine tran...
235
Salmonella essential protein
Phase 4: April 2009
3DHW
23.8%
Salmonella enterica
IDP05041
(
show subtarget assignments
)
1
purified
No
BA_2335
30256973
hypothetical protein BA_2335 [Bacillus a...
64
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05124
(
show subtarget assignments
)
1
purified
No
BA_3893
30258407
putative cell wall hydrolase [Bacillus a...
265
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP04730
(
show subtarget assignments
)
1
cloned
No
BAS4284
49187280
alanyl-tRNA synthetase [Bacillus anthrac...
880
Proposed to be essential proteins
Phase 4: April 2009
1RIQ
26.3%
Bacillus anthracis
IDP05129
(
show subtarget assignments
)
1
cloned
No
CD0091
126697661
adk
adenylate kinase [Clostridium difficile ...
221
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3FB4
57.9%
Clostridium difficile
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
IDP05126
(
show subtarget assignments
)
1
expressed
No
BA_4346
30258846
cpdB
2',3'-cyclic-nucleotide 2'-phosphodieste...
774
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3JYF
20.7%
Bacillus anthracis
Purines, pyrimidines, nucleosides, and nucleotides: Other
IDP04213
(
show subtarget assignments
)
1
cloned
No
STM1003_1_478
16764363
putative transcriptional regulator [Salm...
478
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04395
(
show subtarget assignments
)
1
cloned
No
FTT0076
56707255
sucA
2-oxoglutarate dehydrogenase E1 componen...
941
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2JGD
47.8%
Francisella tularensis
IDP04314
(
show subtarget assignments
)
1
purified
No
YPCD1.73c
5832493
YPCD1.73c
hypothetical protein YPCD1.73c [Yersinia...
149
virulence factor; conserved gene;
Phase 4: April 2009
1JSC
40.7%
Yersinia pestis
IDP04211
(
show subtarget assignments
)
1
expressed
No
STM0408_1_323
16763788
secF
preprotein translocase subunit SecF [Sal...
323
Salmonella essential protein
Phase 4: April 2009
3AQP
35.3%
Salmonella enterica
IDP05038
(
show subtarget assignments
)
1
expressed
No
BA_1902
30256562
multicopper oxidase family protein [Baci...
551
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3T6V
25.8%
Bacillus anthracis
Unknown function: Enzymes of unknown specificity
IDP04625
(
show subtarget assignments
)
1
cloned
No
BAS5050
49188036
glycosyl transferase, group 4 family pro...
357
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP04598
(
show subtarget assignments
)
1
cloned
No
BAS1442
49184459
dihydrodipicolinate reductase [Bacillus ...
266
Proposed to be essential proteins
Phase 4: April 2009
1C3V
40.6%
Bacillus anthracis
IDP04311
(
show subtarget assignments
)
1
purified
No
BAS4340
49187335
50S ribosomal protein L27 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1VSA
55.2%
Bacillus anthracis
IDP05005
(
show subtarget assignments
)
1
cloned
No
CDP11
110666933
hypothetical protein CDP11 [Clostridium ...
33
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP05026
(
show subtarget assignments
)
1
cloned
No
BA_0025
30253539
putative csfB protein [Bacillus anthraci...
59
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Unknown function: General
IDP04414
(
show subtarget assignments
)
8
selected
No
CAC05786
12329055
sepA
SepA, extracellular serine protease of t...
1364
Shigella effector protein
Community Requests
1WXR
34.9%
Shigella flexneri
IDP04582
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0110
49183144
50S ribosomal protein L3 [Bacillus anthr...
210
Proposed to be essential proteins
Phase 4: April 2009
1NKW
53.3%
Bacillus anthracis
IDP04070
(
show subtarget assignments
)
1
cloned
No
FTT0073
56707252
sdhD
succinate dehydrogenase hydrophobic memb...
122
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1NEK
26.2%
Francisella tularensis
IDP05003
(
show subtarget assignments
)
1
cloned
No
BA_3309
30257855
hypothetical protein BA_3309 [Bacillus a...
31
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04067
(
show subtarget assignments
)
1
purified
No
BAS4417
49187412
thioredoxin [Bacillus anthracis str. Ste...
104
Proposed to be essential proteins
Phase 4: April 2009
2GZY
75%
Bacillus anthracis
IDP04258
(
show subtarget assignments
)
1
soluble
No
CPF_2010
110801347
sensory box histidine kinase [Clostridiu...
571
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
17.3%
Clostridium perfringens
Regulatory functions
IDP04218
(
show subtarget assignments
)
1
expressed
No
STM2996_1_1123
16766298
recC
exonuclease V subunit gamma [Salmonella ...
1123
Salmonella essential protein
Phase 4: April 2009
1W36
88.4%
Salmonella enterica
IDP05080
(
show subtarget assignments
)
1
cloned
No
lmo1559
16803599
thrS
threonyl-tRNA synthetase [Listeria monoc...
640
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1NYQ
72%
Listeria monocytogenes
Protein synthesis: tRNA aminoacylation
IDP04210
(
show subtarget assignments
)
1
expressed
No
ZZZ_0017
243
Effector protein
Phase 4: April 2009
2KXC
18.5%
Escherichia coli
IDP04327
(
show subtarget assignments
)
1
cloned
No
CPF_1243
110801193
sensory box histidine kinase [Clostridiu...
623
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
11.2%
Clostridium perfringens
Regulatory functions
IDP04326
(
show subtarget assignments
)
8
purified
No
CAC05800
12329069
ipaA
IpaA, secreted by the Mxi-Spa machinery,...
633
Shigella effector protein
Community Requests
2FM8
10.7%
Shigella flexneri
IDP04224
(
show subtarget assignments
)
8
selected
No
CAC05802
12329071
ipaC
IpaC, secreted by the Mxi-Spa secretion ...
363
Shigella effector protein
Community Requests
Shigella flexneri
IDP04227
(
show subtarget assignments
)
1
expressed
No
CPF_0198
110799765
sensory box histidine kinase [Clostridiu...
791
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
11.6%
Clostridium perfringens
Regulatory functions
IDP04106
(
show subtarget assignments
)
1
cloned
No
BAS0124
49183158
30S ribosomal protein S8 [Bacillus anthr...
132
Proposed to be essential proteins
Phase 4: April 2009
1SEI
85.6%
Bacillus anthracis
IDP04069
(
show subtarget assignments
)
1
in_pdb
3R3T
Yes
BAS5327
49188311
30S ribosomal protein S6 [Bacillus anthr...
96
Proposed to be essential proteins
Phase 4: April 2009
3R3T
100%
Bacillus anthracis
IDP04416
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS4049
49187047
ribonuclease Z [Bacillus anthracis str. ...
307
Proposed to be essential proteins
Phase 4: April 2009
1Y44
61.2%
Bacillus anthracis
IDP05049
(
show subtarget assignments
)
1
soluble
No
BA_5058
30259547
putative lipoprotein [Bacillus anthracis...
271
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP04107
(
show subtarget assignments
)
1
purified
No
BAS0120
49183154
50S ribosomal protein L14 [Bacillus anth...
122
Proposed to be essential proteins
Phase 4: April 2009
1C04
86.9%
Bacillus anthracis
IDP04223
(
show subtarget assignments
)
8
selected
No
CAC05808
12329077
ipgD
IpgD, secreted by the Mxi-Spa machinery,...
538
Shigella effector protein
Community Requests
Shigella flexneri
IDP04732
(
show subtarget assignments
)
1
cloned
No
BAS5341
49188325
50S ribosomal protein L34 [Bacillus anth...
44
Proposed to be essential proteins
Phase 4: April 2009
1NKW
65.9%
Bacillus anthracis
IDP04635
(
show subtarget assignments
)
1
soluble
No
FTT0101
56603768
conserved membrane hypothetical protein ...
337
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
4E94
25.5%
Francisella tularensis
IDP04633
(
show subtarget assignments
)
1
in_pdb
4EEI
No
FTT0015
56707195
purB
adenylosuccinate lyase [Francisella tula...
432
conserved gene; putative drug target function;
Phase 4: April 2009
4EEI
100%
Francisella tularensis
IDP05399
(
show subtarget assignments
)
1
expressed
No
BA_3541
30258076
conserved domain protein [Bacillus anthr...
170
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Domain
IDP05398
(
show subtarget assignments
)
1
soluble
No
BA_3750
30258269
putative phosphonate ABC transporter, ph...
312
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3N5L
21.8%
Bacillus anthracis
Transport and binding proteins: Other
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