Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05204 (show subtarget assignments)	1	expressed	No	CD1723	126699329		acyltransferase [Clostridium difficile 6...	254	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Fatty acid and phospholipid metabolism: Biosynthesis

IDP02438 (show subtarget assignments)	1	cloned	No	CBU_0029	29540654		acyltransferase family protein [Coxiella...	242	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP00625 (show subtarget assignments)	1	cloned	No	SACOL2404	57285135		addiction module toxin, Txe/YoeB family ...	88	Virulence Associated Factor	Phase 2: March 2008	2A6Q	51.1%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00619 (show subtarget assignments)	1	cloned	No	SACOL2464	57286459		addiction module toxin, Txe/YoeB family ...	88	Virulence Associated Factor	Phase 2: March 2008			Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP01230 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4638	33300883		Adenine phosphoribosyltransferase (APRT)...	170	Drug Target Function	Phase 2: March 2008	2DY0	52.4%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP04406 (show subtarget assignments)	1	in_crystallization_trials	No	VC1053	15641066		adenine phosphoribosyltransferase [Vibri...	181	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2DY0	73.5%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP92021 (show subtarget assignments)	8	selected	No	TGME49_005720	237837011		adenosine/AMP deaminase domain containin...	366	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1A4L	25.7%	Toxoplasma gondii

IDP92118 (show subtarget assignments)	8	selected	No	TGME49_015480	237843139		adenosine/AMP deaminase domain containin...	515	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3OU8	21.7%	Toxoplasma gondii

IDP00965 (show subtarget assignments)	1	purified	No	STM1463	16764811	add	adenosine deaminase	333	Conserved Gene / Pathway	Phase 2: March 2008	1NDV	33.8%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP04388 (show subtarget assignments)	1	soluble	No	VC2751	15642744		adenosine deaminase [Vibrio cholerae O1 ...	334	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A4L	32.7%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP92013 (show subtarget assignments)	8	selected	No	TGME49_034280	237839141		adenosine monophosphate deaminase, putat...	914	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2A3L	30.4%	Toxoplasma gondii

IDP90627 (show subtarget assignments)	8	selected	No	VC1239	15641252	cobU	adenosylcobinamide kinase/adenosylcobina...	179	Predicted Essential	Community Requests	1C9K	41.3%	Vibrio cholerae

IDP91423 (show subtarget assignments)	8	expressed	No	VV1_0559	27364021		adenosylcobinamide-phosphate synthase [V...	317	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP92093 (show subtarget assignments)	8	selected	No	TGME49_025050	237833761		adenosylhomocysteinase, putative [Toxopl...	477	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3OND	68.6%	Toxoplasma gondii

IDP01797 (show subtarget assignments)	1	cloned	No	CBU_1008	29541590	bioA	adenosylmethionine-8-amino-7-oxononanoat...	442	Conserved; Drug target functions	Phase 3: June 2008	3DOD	35.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04281 (show subtarget assignments)	1	cloned	No	YPO1150	115346925	bioA	adenosylmethionine-8-amino-7-oxononanoat...	422	conserved gene; putative drug target function;	Phase 4: April 2009	1MLY	73.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00936 (show subtarget assignments)	1	soluble	No	STM0793	16764156	bioA	adenosylmethionine--8-amino-7-oxononanoa...	429	Conserved Gene / Pathway	Phase 2: March 2008	1MLY	86.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02725 (show subtarget assignments)	1	crystallized	No	GBAA4341	47529638	bioA	adenosylmethionine--8-amino-7-oxononanoa...	462	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DOD	57.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00480 (show subtarget assignments)	1	soluble	No	YPO3118	16123283	adk	adenylate kinase	214	Conserved Gene / Pathway	Phase 2: March 2008	1AKE	87.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP04119 (show subtarget assignments)	1	crystallized	No	BAS0131	49183165		adenylate kinase [Bacillus anthracis str...	216	Proposed to be essential proteins	Phase 4: April 2009	1ZIN	74.1%	Bacillus anthracis

IDP02084 (show subtarget assignments)	1	in_crystallization_trials	No	Cj0639c	15791999	adk	adenylate kinase [Campylobacter jejuni s...	192	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1P4S	34.9%	Campylobacter jejuni	Energy metabolism	Electron transport

IDP05129 (show subtarget assignments)	1	cloned	No	CD0091	126697661	adk	adenylate kinase [Clostridium difficile ...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3FB4	57.9%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP91820 (show subtarget assignments)	8	soluble	No	b0474	1786680	adk	adenylate kinase [Escherichia coli str. ...	214	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1AKE	100%	Escherichia coli

IDP02287 (show subtarget assignments)	1	purified	No	FTT1161	56708232	adk	adenylate kinase [Francisella tularensis...	218	Drug Target	Phase 3: June 2008	1AKE	56.4%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP92034 (show subtarget assignments)	8	selected	No	TGME49_024900	237833733		adenylate kinase, putative [Toxoplasma g...	257	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3TLX	55.6%	Toxoplasma gondii

IDP04500 (show subtarget assignments)	1	crystallized	No	VC0986	15641001	adk	adenylate kinase [Vibrio cholerae O1 bio...	214	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1AKE	73.4%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP04255 (show subtarget assignments)	1	cloned	No	CPF_1922	110799469	purB	adenylosuccinate lyase [Clostridium perf...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2J91	56.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04633 (show subtarget assignments)	1	in_pdb 4EEI	No	FTT0015	56707195	purB	adenylosuccinate lyase [Francisella tula...	432	conserved gene; putative drug target function;	Phase 4: April 2009	4EEI	100%	Francisella tularensis

IDP92060 (show subtarget assignments)	8	selected	No	TGME49_063190	237832243		adenylosuccinate lyase, putative [Toxopl...	500	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2PTS	43.2%	Toxoplasma gondii

IDP00422 (show subtarget assignments)	1	in_pdb 3HID	No	YPO0378	16120713	purA	adenylosuccinate synthetase	432	Virulence Associated Factor	Phase 2: March 2008	3HID	100%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01765 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5716	47531053	purA	adenylosuccinate synthetase [Bacillus an...	429	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GIM	47.1%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90608 (show subtarget assignments)	8	in_pdb 3R7T	No	Cj1498c	15792813	purA	adenylosuccinate synthetase [Campylobact...	416	Predicted Essential	Community Requests	3R7T	100%	Campylobacter jejuni

IDP04208 (show subtarget assignments)	1	purified	No	CPF_2958	110799195	purA	adenylosuccinate synthetase [Clostridium...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1IWE	47.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04312 (show subtarget assignments)	1	cloned	No	FTT0204	56707368	purA	adenylosuccinate synthetase [Francisella...	428	conserved gene;	Phase 4: April 2009	1ADE	45.9%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP92106 (show subtarget assignments)	8	selected	No	TGME49_079450	237845375		adenylosuccinate synthetase, putative [T...	460	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1P9B	48.7%	Toxoplasma gondii

IDP04404 (show subtarget assignments)	1	cloned	No	VC2602	15642597		adenylosuccinate synthetase [Vibrio chol...	432	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KJX	75.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02377 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1442	47526717	cysC	adenylylsulfate kinase [Bacillus anthrac...	197	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3UIE	51.3%	Bacillus anthracis	Central intermediary metabolism	Sulfur metabolism

IDP91042 (show subtarget assignments)	8	in_crystallization_trials	No	ACB0002	38230268		AdeR [Acinetobacter baumannii]	247	Regulator protein of transcription of antibiotic drug-efflux pump AdeABC	Community Requests	2GWR	33.2%	Acinetobacter baumannii

IDP04682 (show subtarget assignments)	1	cloned	No	GBAA3189	47528481		adhesion lipoprotein [Bacillus anthracis...	311	virulence factor; putative drug target function;	Phase 4: April 2009	3HH8	49.8%	Bacillus anthracis	Cell envelope	Other

IDP00078 (show subtarget assignments)	0	work_stopped	No	NTL01ST3606	16422278	rfaF	ADP-heptose; LPS heptosyltransferase 1	348		Phase 1: October 2007	1PSW	91.7%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00123 (show subtarget assignments)	1	expressed	No	NT01ST4633	16766997	rfaC	ADP-heptose:LPS heptosyl transferase I	317	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GT1	83.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02602 (show subtarget assignments)	1	cloned	No	Cj1148	15792472	waaF	ADP-heptose--LPS heptosyltransferase II ...	319	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	1PSW	24.7%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91406 (show subtarget assignments)	8	cloned	No	VV1_0798	27364247		ADP-heptose--LPS heptosyltransferase II ...	352	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1PSW	50.3%	Vibrio vulnificus

IDP90918 (show subtarget assignments)	8	in_crystallization_trials	No	YPO0057	16120410	rfaF	ADP-heptose:LPS heptosyltransferase II [...	354	Predicted Essential	Community Requests	1PSW	72.3%	Yersinia pestis

IDP90822 (show subtarget assignments)	8	purified	No	YPO0056	16120409	rfaC	ADP-heptose:LPS heptosyl transferase I [...	321	Predicted Essential	Community Requests	2GT1	67.9%	Yersinia pestis

IDP90552 (show subtarget assignments)	8	soluble	No	YPO0058	16120411	rfaD	ADP-L-glycero-D-mannoheptose-6-epimerase...	310	Predicted Essential	Community Requests	1EQ2	82.3%	Yersinia pestis

IDP02551 (show subtarget assignments)	1	cloned	No	Cj1151c	15792475	waaD	ADP-L-glycero-D-mannoheptose-6-epimerase...	317	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	3SXP	48.6%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP90559 (show subtarget assignments)	8	cloned	No	VC0240	15640270	rfaD	ADP-L-glycero-D-mannoheptose-6-epimerase...	314	Predicted Essential	Community Requests	1EQ2	73.9%	Vibrio cholerae

IDP91425 (show subtarget assignments)	8	soluble	No	VV1_0550	27364012		aerobic respiration control sensor prote...	780	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3A0R	11.7%	Vibrio vulnificus

IDP00814 (show subtarget assignments)	1	purified	No	SACOL2006	57284880		Aerolysin/Leukocidin family protein	351	Conserved Gene / Pathway	Phase 2: March 2008	3ROH	30.8%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP01346 (show subtarget assignments)	1	cloned	No	VC1621	15641628		agglutination protein	445	Conserved Gene / Pathway	Phase 2: March 2008	2VDD	24.9%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP91514 (show subtarget assignments)	8	expressed	No	VV2_1517	27367864		agglutination protein [Vibrio vulnificus...	436	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1YC9	16.5%	Vibrio vulnificus

IDP00684 (show subtarget assignments)	1	cloned	No	SACOL1926	57286273	mutY	A/G-specific adenine glycosylase	345	Drug Target Function	Phase 2: March 2008	3FSP	45.8%	Staphylococcus aureus	DNA metabolism	DNA replication, recombination, and repair

IDP02290 (show subtarget assignments)	1	expressed	No	GBAA3674	47528959		ahpC/TSA family protein [Bacillus anthra...	191	Drug target motif; Involved in sporulation;	Phase 3: June 2008	1ST9	29.8%	Bacillus anthracis	Unknown function	General

IDP01762 (show subtarget assignments)	1	soluble	No	FTT0557	56707687		AhpC/TSA family protein [Francisella tul...	174	Drug Target	Phase 3: June 2008	1NM3	54%	Francisella tularensis	Cellular processes	Detoxification

IDP00900 (show subtarget assignments)	0	work_stopped	No	STM4247	16767497	alr	alanine racemase	359	Conserved Gene / Pathway	Phase 2: March 2008	2RJG	91.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01513 (show subtarget assignments)	1	purified	No	VC1312	161582006	alr	alanine racemase	407	Conserved Gene / Pathway	Phase 2: March 2008	4ECL	26%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01202 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2079	30256728	dal-2	alanine racemase	391	Drug Target Function	Phase 2: March 2008	3E5P	41.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01375 (show subtarget assignments)	1	in_crystallization_trials	No	VC0372	15640399	alr	alanine racemase	375	Conserved Gene / Pathway	Phase 2: March 2008	2RJG	57.3%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00688 (show subtarget assignments)	1	in_pdb 3OO2	Yes	SACOL2060	57284928	alr	alanine racemase	382	Conserved Gene / Pathway	Phase 2: March 2008	3OO2	100%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04441 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0321	115346137	alr	alanine racemase (biosynthetic) [Yersini...	359	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2RJG	71.9%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01676 (show subtarget assignments)	1	cloned	No	CBU_0869	29541462	alr	alanine racemase [Coxiella burnetii RSA ...	364	Conserved; Drug target functions	Phase 3: June 2008	2RJG	42.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00718 (show subtarget assignments)	1	soluble	No	SACOL1434	57286085		alanine racemase family protein	361	Conserved Gene / Pathway	Phase 2: March 2008	2RJG	27.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02469 (show subtarget assignments)	1	cloned	No	FTT0573	56707702	alr	alanine racemase [Francisella tularensis...	365	Conserved; Drug target functions	Phase 3: June 2008	4A3Q	31.7%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91529 (show subtarget assignments)	8	soluble	No	VC_1312	9655801		alanine racemase, putative [Vibrio chole...	428	other biological interest / The protein we are submitting is a broad spectrum amino acid racemase (Lam et al...	Community Requests	4ECL	24.8%	Vibrio cholerae

IDP04730 (show subtarget assignments)	1	cloned	No	BAS4284	49187280		alanyl-tRNA synthetase [Bacillus anthrac...	880	Proposed to be essential proteins	Phase 4: April 2009	1RIQ	26.3%	Bacillus anthracis

IDP90679 (show subtarget assignments)	8	cloned	No	Cj0506	15791868	alaS	alanyl-tRNA synthetase [Campylobacter je...	842	Predicted Essential	Community Requests	3HXU	28.5%	Campylobacter jejuni

IDP05327 (show subtarget assignments)	1	cloned	No	lmo1504	16803544	alaS	alanyl-tRNA synthetase [Listeria monocyt...	879	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1RIQ	25.8%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP92131 (show subtarget assignments)	8	selected	No	TGME49_019540	237842821		alanyl-tRNA synthetase, putative [Toxopl...	1037	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2ZZF	21.2%	Toxoplasma gondii

IDP05710 (show subtarget assignments)	1	cloned	No	SACOL1673	57650500	alaS	alanyl-tRNA synthetase [Staphylococcus a...	876	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1RIQ	25.9%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP90826 (show subtarget assignments)	8	cloned	No	YPO3305	16123458	alaS	alanyl-tRNA synthetase [Yersinia pestis ...	875	Predicted Essential	Community Requests	3HXU	45%	Yersinia pestis

IDP00757 (show subtarget assignments)	1	soluble	No	SACOL0135	57285338		alcohol dehydrogenase, iron-containing	869	Conserved Gene / Pathway	Phase 2: March 2008	3MY7	25.3%	Staphylococcus aureus	Energy metabolism	Fermentation

IDP00011 (show subtarget assignments)	1	soluble	No	BA_2222	30256868		alcohol dehydrogenase, iron-containing	392	Drug Target Homolog	Phase 1: October 2007	3OWO	37.8%	Bacillus anthracis	Energy metabolism	Fermentation

IDP04681 (show subtarget assignments)	1	soluble	No	GBAA3131	47528422	adhB	alcohol dehydrogenase, zinc-containing [...	377	virulence factor; putative drug target function;	Phase 4: April 2009	1KOL	31.9%	Bacillus anthracis	Energy metabolism	Fermentation

IDP04685 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3438	47528724		alcohol dehydrogenase, zinc-containing [...	335	virulence factor; putative drug target function;	Phase 4: April 2009	3GAZ	37.3%	Bacillus anthracis	Energy metabolism	Fermentation

IDP00001 (show subtarget assignments)	1	cloned	No	BA_4599	30259099		aldehyde-alcohol dehydrogenase	867	Drug Target Homolog	Phase 1: October 2007	3MY7	24.5%	Bacillus anthracis	Energy metabolism	Fermentation

IDP02108 (show subtarget assignments)	1	in_crystallization_trials	No	STM3680	16766965	aldB	aldehyde dehydrogenase B [Salmonella typ...	512	Conserved; Drug target functions	Phase 3: June 2008	1NZW	40.6%	Salmonella enterica	Energy metabolism	Other

IDP02247 (show subtarget assignments)	1	expressed	No	FTT0665c	56707786		aldolase/adducin class II family protein...	201	Drug Target	Phase 3: June 2008	3OCR	32.3%	Francisella tularensis	Unknown function	General

IDP01763 (show subtarget assignments)	1	cloned	No	YPO3627	16123769	ssuB	aliphatic sulfonates transport ATP-bindi...	271	Conserved; CD; Drug target functions	Phase 3: June 2008	2IT1	35.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP02331 (show subtarget assignments)	1	selected	No	GBAA2661	47527952	adP-1	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	30.7%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02566 (show subtarget assignments)	1	purified	No	GBAA3033	50196939	adP-2	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	31.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05723 (show subtarget assignments)	1	expressed	No	BA_3001	30257589		alkaline phosphatase [Bacillus anthracis...	557	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3A52	25.3%	Bacillus anthracis	Central intermediary metabolism: Other

IDP90595 (show subtarget assignments)	8	expressed	No	YPO2298	16122522	phoA	alkaline phosphatase [Yersinia pestis CO...	481	Predicted Essential	Community Requests	1B8J	70.7%	Yersinia pestis

IDP01361 (show subtarget assignments)	1	expressed	No	VC0157	15640187		alkaline serine protease	535	Drug Target Function	Phase 2: March 2008	1S2N	35.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02761 (show subtarget assignments)	1	soluble	No	GBAA2380	47527675		alkaline serine protease [Bacillus anthr...	397	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1THM	51.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01119 (show subtarget assignments)	1	purified	No	BA_0344	30253882	ahpF	alkyl hydroperoxide reductase, F subunit...	508	Conserved Gene / Pathway	Phase 2: March 2008	1HYU	55.7%	Bacillus anthracis	Cellular processes	Detoxification

IDP00653 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0451	57286824	ahpF	alkyl hydroperoxide reductase, subunit F...	507	Conserved Gene / Pathway	Phase 2: March 2008	1HYU	53.8%	Staphylococcus aureus	Cellular processes	Detoxification

IDP02647 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0537	16802580		allantoate amidohydrolase [Listeria mono...	423	Presence of Protease Motifs; DNA binding Motifs	Phase 3: June 2008	3N5F	38.1%	Listeria monocytogenes	Energy metabolism	Amino acids and amines

IDP91692 (show subtarget assignments)	8	selected	No	NP_001093	4501891	ACTN1	alpha-actinin-1 isoform b [Homo sapiens]...	892	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1SJJ	93.3%	Homo sapiens

IDP90118 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_028	68449102		alpha-amanitin target protein [Monkeypox...	177	similar to VACV-COP-N2L, MPXV-ZAI96-P2L	Community Requests			Monkeypox virus

IDP01138 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4230	30258733		alpha-amylase	586	Drug Target Function	Phase 2: March 2008	1J0H	61%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP05122 (show subtarget assignments)	1	expressed	No	BA_3551	30258083	amyS	alpha-amylase [Bacillus anthracis str. A...	513	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1VJS	68.6%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05361 (show subtarget assignments)	1	cloned	No	BA_1162	30254880		alpha-amylase family protein [Bacillus a...	433	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1CYG	26.7%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02300 (show subtarget assignments)	1	soluble	No	GBAA1860	47527151		alpha/beta fold family hydrolase [Bacill...	307	Drug target motif; Involved in sporulation;	Phase 3: June 2008	3HJU	26.7%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP91995 (show subtarget assignments)	8	selected	No	SpneCM_010100003595	298254684		alpha-glycerophosphate oxidase (Glycerol...	608	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2RGO	62%	Streptococcus pneumoniae

IDP00567 (show subtarget assignments)	0	work_stopped	No	YPO1113	16121413	kgd	alpha-ketoglutarate decarboxylase	935	Virulence Associated Factor	Phase 2: March 2008	2JGD	87.8%	Yersinia pestis	Energy metabolism	TCA cycle

IDP05771 (show subtarget assignments)	1	cloned	No	Z0339	12513053		alpha replication protein of prophage CP...	777	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1KA8	9.5%	Escherichia coli	Mobile and extrachromosomal element functions: Prophage functions

IDP90907 (show subtarget assignments)	8	purified	No	STM0643	16764020	cobC	alpha ribazole-5'-P phosphatase [Salmone...	202	Predicted Essential	Community Requests	2P9Z	30.7%	Salmonella enterica

IDP90806 (show subtarget assignments)	8	crystallized	No	S0665	30062173	phpB	alpha-ribazole phosphatase [Shigella fle...	203	Predicted Essential	Community Requests	3HJG	28.4%	Shigella flexneri

IDP04246 (show subtarget assignments)	1	cloned	No	CPF_1362	110799745		aluminum resistance protein [Clostridium...	426	conserved gene; putative drug target function;	Phase 4: April 2009	3GWP	71.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP05204
(show subtarget assignments)

1

expressed

No

CD1723

126699329

acyltransferase [Clostridium difficile 6...

254

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Fatty acid and phospholipid metabolism: Biosynthesis

IDP02438
(show subtarget assignments)

1

cloned

No

CBU_0029

29540654

acyltransferase family protein [Coxiella...

242

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP00625
(show subtarget assignments)

1

cloned

No

SACOL2404

57285135

addiction module toxin, Txe/YoeB family ...

88

Virulence Associated Factor

Phase 2: March 2008

2A6Q

51.1%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00619
(show subtarget assignments)

1

cloned

No

SACOL2464

57286459

addiction module toxin, Txe/YoeB family ...

88

Virulence Associated Factor

Phase 2: March 2008

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP01230
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4638

33300883

Adenine phosphoribosyltransferase (APRT)...

170

Drug Target Function

Phase 2: March 2008

2DY0

52.4%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP04406
(show subtarget assignments)

1

in_crystallization_trials

No

VC1053

15641066

adenine phosphoribosyltransferase [Vibri...

181

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2DY0

73.5%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP92021
(show subtarget assignments)

8

selected

No

TGME49_005720

237837011

adenosine/AMP deaminase domain containin...

366

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1A4L

25.7%

Toxoplasma gondii

IDP92118
(show subtarget assignments)

8

selected

No

TGME49_015480

237843139

adenosine/AMP deaminase domain containin...

515

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3OU8

21.7%

Toxoplasma gondii

IDP00965
(show subtarget assignments)

1

purified

No

STM1463

16764811

add

adenosine deaminase

333

Conserved Gene / Pathway

Phase 2: March 2008

1NDV

33.8%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP04388
(show subtarget assignments)

1

soluble

No

VC2751

15642744

adenosine deaminase [Vibrio cholerae O1 ...

334

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A4L

32.7%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP92013
(show subtarget assignments)

8

selected

No

TGME49_034280

237839141

adenosine monophosphate deaminase, putat...

914

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2A3L

30.4%

Toxoplasma gondii

IDP90627
(show subtarget assignments)

8

selected

No

VC1239

15641252

cobU

adenosylcobinamide kinase/adenosylcobina...

179

Predicted Essential

Community Requests

1C9K

41.3%

Vibrio cholerae

IDP91423
(show subtarget assignments)

8

expressed

No

VV1_0559

27364021

adenosylcobinamide-phosphate synthase [V...

317

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP92093
(show subtarget assignments)

8

selected

No

TGME49_025050

237833761

adenosylhomocysteinase, putative [Toxopl...

477

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3OND

68.6%

Toxoplasma gondii

IDP01797
(show subtarget assignments)

1

cloned

No

CBU_1008

29541590

bioA

adenosylmethionine-8-amino-7-oxononanoat...

442

Conserved; Drug target functions

Phase 3: June 2008

3DOD

35.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04281
(show subtarget assignments)

1

cloned

No

YPO1150

115346925

bioA

adenosylmethionine-8-amino-7-oxononanoat...

422

conserved gene; putative drug target function;

Phase 4: April 2009

1MLY

73.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00936
(show subtarget assignments)

1

soluble

No

STM0793

16764156

bioA

adenosylmethionine--8-amino-7-oxononanoa...

429

Conserved Gene / Pathway

Phase 2: March 2008

1MLY

86.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02725
(show subtarget assignments)

1

crystallized

No

GBAA4341

47529638

bioA

adenosylmethionine--8-amino-7-oxononanoa...

462

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DOD

57.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00480
(show subtarget assignments)

1

soluble

No

YPO3118

16123283

adk

adenylate kinase

214

Conserved Gene / Pathway

Phase 2: March 2008

1AKE

87.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP04119
(show subtarget assignments)

1

crystallized

No

BAS0131

49183165

adenylate kinase [Bacillus anthracis str...

216

Proposed to be essential proteins

Phase 4: April 2009

1ZIN

74.1%

Bacillus anthracis

IDP02084
(show subtarget assignments)

1

in_crystallization_trials

No

Cj0639c

15791999

adk

adenylate kinase [Campylobacter jejuni s...

192

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1P4S

34.9%

Campylobacter jejuni

Energy metabolism

Electron transport

IDP05129
(show subtarget assignments)

1

cloned

No

CD0091

126697661

adk

adenylate kinase [Clostridium difficile ...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3FB4

57.9%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP91820
(show subtarget assignments)

8

soluble

No

b0474

1786680

adk

adenylate kinase [Escherichia coli str. ...

214

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1AKE

100%

Escherichia coli

IDP02287
(show subtarget assignments)

1

purified

No

FTT1161

56708232

adk

adenylate kinase [Francisella tularensis...

218

Drug Target

Phase 3: June 2008

1AKE

56.4%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP92034
(show subtarget assignments)

8

selected

No

TGME49_024900

237833733

adenylate kinase, putative [Toxoplasma g...

257

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3TLX

55.6%

Toxoplasma gondii

IDP04500
(show subtarget assignments)

1

crystallized

No

VC0986

15641001

adk

adenylate kinase [Vibrio cholerae O1 bio...

214

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1AKE

73.4%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP04255
(show subtarget assignments)

1

cloned

No

CPF_1922

110799469

purB

adenylosuccinate lyase [Clostridium perf...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2J91

56.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04633
(show subtarget assignments)

1

in_pdb
4EEI

No

FTT0015

56707195

purB

adenylosuccinate lyase [Francisella tula...

432

conserved gene; putative drug target function;

Phase 4: April 2009

4EEI

100%

Francisella tularensis

IDP92060
(show subtarget assignments)

8

selected

No

TGME49_063190

237832243

adenylosuccinate lyase, putative [Toxopl...

500

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2PTS

43.2%

Toxoplasma gondii

IDP00422
(show subtarget assignments)

1

in_pdb
3HID

No

YPO0378

16120713

purA

adenylosuccinate synthetase

432

Virulence Associated Factor

Phase 2: March 2008

3HID

100%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01765
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5716

47531053

purA

adenylosuccinate synthetase [Bacillus an...

429

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GIM

47.1%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90608
(show subtarget assignments)

8

in_pdb
3R7T

No

Cj1498c

15792813

purA

adenylosuccinate synthetase [Campylobact...

416

Predicted Essential

Community Requests

3R7T

100%

Campylobacter jejuni

IDP04208
(show subtarget assignments)

1

purified

No

CPF_2958

110799195

purA

adenylosuccinate synthetase [Clostridium...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1IWE

47.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04312
(show subtarget assignments)

1

cloned

No

FTT0204

56707368

purA

adenylosuccinate synthetase [Francisella...

428

conserved gene;

Phase 4: April 2009

1ADE

45.9%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP92106
(show subtarget assignments)

8

selected

No

TGME49_079450

237845375

adenylosuccinate synthetase, putative [T...

460

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1P9B

48.7%

Toxoplasma gondii

IDP04404
(show subtarget assignments)

1

cloned

No

VC2602

15642597

adenylosuccinate synthetase [Vibrio chol...

432

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KJX

75.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02377
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1442

47526717

cysC

adenylylsulfate kinase [Bacillus anthrac...

197

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3UIE

51.3%

Bacillus anthracis

Central intermediary metabolism

Sulfur metabolism

IDP91042
(show subtarget assignments)

8

in_crystallization_trials

No

ACB0002

38230268

AdeR [Acinetobacter baumannii]

247

Regulator protein of transcription of antibiotic drug-efflux pump AdeABC

Community Requests

2GWR

33.2%

Acinetobacter baumannii

IDP04682
(show subtarget assignments)

1

cloned

No

GBAA3189

47528481

adhesion lipoprotein [Bacillus anthracis...

311

virulence factor; putative drug target function;

Phase 4: April 2009

3HH8

49.8%

Bacillus anthracis

Cell envelope

Other

IDP00078
(show subtarget assignments)

0

work_stopped

No

NTL01ST3606

16422278

rfaF

ADP-heptose; LPS heptosyltransferase 1

348

Phase 1: October 2007

1PSW

91.7%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00123
(show subtarget assignments)

1

expressed

No

NT01ST4633

16766997

rfaC

ADP-heptose:LPS heptosyl transferase I

317

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GT1

83.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02602
(show subtarget assignments)

1

cloned

No

Cj1148

15792472

waaF

ADP-heptose--LPS heptosyltransferase II ...

319

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

1PSW

24.7%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91406
(show subtarget assignments)

8

cloned

No

VV1_0798

27364247

ADP-heptose--LPS heptosyltransferase II ...

352

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1PSW

50.3%

Vibrio vulnificus

IDP90918
(show subtarget assignments)

8

in_crystallization_trials

No

YPO0057

16120410

rfaF

ADP-heptose:LPS heptosyltransferase II [...

354

Predicted Essential

Community Requests

1PSW

72.3%

Yersinia pestis

IDP90822
(show subtarget assignments)

8

purified

No

YPO0056

16120409

rfaC

ADP-heptose:LPS heptosyl transferase I [...

321

Predicted Essential

Community Requests

2GT1

67.9%

Yersinia pestis

IDP90552
(show subtarget assignments)

8

soluble

No

YPO0058

16120411

rfaD

ADP-L-glycero-D-mannoheptose-6-epimerase...

310

Predicted Essential

Community Requests

1EQ2

82.3%

Yersinia pestis

IDP02551
(show subtarget assignments)

1

cloned

No

Cj1151c

15792475

waaD

ADP-L-glycero-D-mannoheptose-6-epimerase...

317

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

3SXP

48.6%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP90559
(show subtarget assignments)

8

cloned

No

VC0240

15640270

rfaD

ADP-L-glycero-D-mannoheptose-6-epimerase...

314

Predicted Essential

Community Requests

1EQ2

73.9%

Vibrio cholerae

IDP91425
(show subtarget assignments)

8

soluble

No

VV1_0550

27364012

aerobic respiration control sensor prote...

780

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3A0R

11.7%

Vibrio vulnificus

IDP00814
(show subtarget assignments)

1

purified

No

SACOL2006

57284880

Aerolysin/Leukocidin family protein

351

Conserved Gene / Pathway

Phase 2: March 2008

3ROH

30.8%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP01346
(show subtarget assignments)

1

cloned

No

VC1621

15641628

agglutination protein

445

Conserved Gene / Pathway

Phase 2: March 2008

2VDD

24.9%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP91514
(show subtarget assignments)

8

expressed

No

VV2_1517

27367864

agglutination protein [Vibrio vulnificus...

436

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1YC9

16.5%

Vibrio vulnificus

IDP00684
(show subtarget assignments)

1

cloned

No

SACOL1926

57286273

mutY

A/G-specific adenine glycosylase

345

Drug Target Function

Phase 2: March 2008

3FSP

45.8%

Staphylococcus aureus

DNA metabolism

DNA replication, recombination, and repair

IDP02290
(show subtarget assignments)

1

expressed

No

GBAA3674

47528959

ahpC/TSA family protein [Bacillus anthra...

191

Drug target motif; Involved in sporulation;

Phase 3: June 2008

1ST9

29.8%

Bacillus anthracis

Unknown function

General

IDP01762
(show subtarget assignments)

1

soluble

No

FTT0557

56707687

AhpC/TSA family protein [Francisella tul...

174

Drug Target

Phase 3: June 2008

1NM3

54%

Francisella tularensis

Cellular processes

Detoxification

IDP00900
(show subtarget assignments)

0

work_stopped

No

STM4247

16767497

alr

alanine racemase

359

Conserved Gene / Pathway

Phase 2: March 2008

2RJG

91.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01513
(show subtarget assignments)

1

purified

No

VC1312

161582006

alr

alanine racemase

407

Conserved Gene / Pathway

Phase 2: March 2008

4ECL

26%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01202
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2079

30256728

dal-2

alanine racemase

391

Drug Target Function

Phase 2: March 2008

3E5P

41.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01375
(show subtarget assignments)

1

in_crystallization_trials

No

VC0372

15640399

alr

alanine racemase

375

Conserved Gene / Pathway

Phase 2: March 2008

2RJG

57.3%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00688
(show subtarget assignments)

1

in_pdb
3OO2

Yes

SACOL2060

57284928

alr

alanine racemase

382

Conserved Gene / Pathway

Phase 2: March 2008

3OO2

100%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04441
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0321

115346137

alr

alanine racemase (biosynthetic) [Yersini...

359

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2RJG

71.9%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01676
(show subtarget assignments)

1

cloned

No

CBU_0869

29541462

alr

alanine racemase [Coxiella burnetii RSA ...

364

Conserved; Drug target functions

Phase 3: June 2008

2RJG

42.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00718
(show subtarget assignments)

1

soluble

No

SACOL1434

57286085

alanine racemase family protein

361

Conserved Gene / Pathway

Phase 2: March 2008

2RJG

27.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02469
(show subtarget assignments)

1

cloned

No

FTT0573

56707702

alr

alanine racemase [Francisella tularensis...

365

Conserved; Drug target functions

Phase 3: June 2008

4A3Q

31.7%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91529
(show subtarget assignments)

8

soluble

No

VC_1312

9655801

alanine racemase, putative [Vibrio chole...

428

other biological interest / The protein we are submitting is a broad spectrum amino acid racemase (Lam et al...

Community Requests

4ECL

24.8%

Vibrio cholerae

IDP04730
(show subtarget assignments)

1

cloned

No

BAS4284

49187280

alanyl-tRNA synthetase [Bacillus anthrac...

880

Proposed to be essential proteins

Phase 4: April 2009

1RIQ

26.3%

Bacillus anthracis

IDP90679
(show subtarget assignments)

8

cloned

No

Cj0506

15791868

alaS

alanyl-tRNA synthetase [Campylobacter je...

842

Predicted Essential

Community Requests

3HXU

28.5%

Campylobacter jejuni

IDP05327
(show subtarget assignments)

1

cloned

No

lmo1504

16803544

alaS

alanyl-tRNA synthetase [Listeria monocyt...

879

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1RIQ

25.8%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP92131
(show subtarget assignments)

8

selected

No

TGME49_019540

237842821

alanyl-tRNA synthetase, putative [Toxopl...

1037

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2ZZF

21.2%

Toxoplasma gondii

IDP05710
(show subtarget assignments)

1

cloned

No

SACOL1673

57650500

alaS

alanyl-tRNA synthetase [Staphylococcus a...

876

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1RIQ

25.9%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP90826
(show subtarget assignments)

8

cloned

No

YPO3305

16123458

alaS

alanyl-tRNA synthetase [Yersinia pestis ...

875

Predicted Essential

Community Requests

3HXU

45%

Yersinia pestis

IDP00757
(show subtarget assignments)

1

soluble

No

SACOL0135

57285338

alcohol dehydrogenase, iron-containing

869

Conserved Gene / Pathway

Phase 2: March 2008

3MY7

25.3%

Staphylococcus aureus

Energy metabolism

Fermentation

IDP00011
(show subtarget assignments)

1

soluble

No

BA_2222

30256868

alcohol dehydrogenase, iron-containing

392

Drug Target Homolog

Phase 1: October 2007

3OWO

37.8%

Bacillus anthracis

Energy metabolism

Fermentation

IDP04681
(show subtarget assignments)

1

soluble

No

GBAA3131

47528422

adhB

alcohol dehydrogenase, zinc-containing [...

377

virulence factor; putative drug target function;

Phase 4: April 2009

1KOL

31.9%

Bacillus anthracis

Energy metabolism

Fermentation

IDP04685
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3438

47528724

alcohol dehydrogenase, zinc-containing [...

335

virulence factor; putative drug target function;

Phase 4: April 2009

3GAZ

37.3%

Bacillus anthracis

Energy metabolism

Fermentation

IDP00001
(show subtarget assignments)

1

cloned

No

BA_4599

30259099

aldehyde-alcohol dehydrogenase

867

Drug Target Homolog

Phase 1: October 2007

3MY7

24.5%

Bacillus anthracis

Energy metabolism

Fermentation

IDP02108
(show subtarget assignments)

1

in_crystallization_trials

No

STM3680

16766965

aldB

aldehyde dehydrogenase B [Salmonella typ...

512

Conserved; Drug target functions

Phase 3: June 2008

1NZW

40.6%

Salmonella enterica

Energy metabolism

Other

IDP02247
(show subtarget assignments)

1

expressed

No

FTT0665c

56707786

aldolase/adducin class II family protein...

201

Drug Target

Phase 3: June 2008

3OCR

32.3%

Francisella tularensis

Unknown function

General

IDP01763
(show subtarget assignments)

1

cloned

No

YPO3627

16123769

ssuB

aliphatic sulfonates transport ATP-bindi...

271

Conserved; CD; Drug target functions

Phase 3: June 2008

2IT1

35.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP02331
(show subtarget assignments)

1

selected

No

GBAA2661

47527952

adP-1

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

30.7%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02566
(show subtarget assignments)

1

purified

No

GBAA3033

50196939

adP-2

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

31.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05723
(show subtarget assignments)

1

expressed

No

BA_3001

30257589

alkaline phosphatase [Bacillus anthracis...

557

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3A52

25.3%

Bacillus anthracis

Central intermediary metabolism: Other

IDP90595
(show subtarget assignments)

8

expressed

No

YPO2298

16122522

phoA

alkaline phosphatase [Yersinia pestis CO...

481

Predicted Essential

Community Requests

1B8J

70.7%

Yersinia pestis

IDP01361
(show subtarget assignments)

1

expressed

No

VC0157

15640187

alkaline serine protease

535

Drug Target Function

Phase 2: March 2008

1S2N

35.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02761
(show subtarget assignments)

1

soluble

No

GBAA2380

47527675

alkaline serine protease [Bacillus anthr...

397

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1THM

51.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01119
(show subtarget assignments)

1

purified

No

BA_0344

30253882

ahpF

alkyl hydroperoxide reductase, F subunit...

508

Conserved Gene / Pathway

Phase 2: March 2008

1HYU

55.7%

Bacillus anthracis

Cellular processes

Detoxification

IDP00653
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0451

57286824

ahpF

alkyl hydroperoxide reductase, subunit F...

507

Conserved Gene / Pathway

Phase 2: March 2008

1HYU

53.8%

Staphylococcus aureus

Cellular processes

Detoxification

IDP02647
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0537

16802580

allantoate amidohydrolase [Listeria mono...

423

Presence of Protease Motifs; DNA binding Motifs

Phase 3: June 2008

3N5F

38.1%

Listeria monocytogenes

Energy metabolism

Amino acids and amines

IDP91692
(show subtarget assignments)

8

selected

No

NP_001093

4501891

ACTN1

alpha-actinin-1 isoform b [Homo sapiens]...

892

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1SJJ

93.3%

Homo sapiens

IDP90118
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_028

68449102

alpha-amanitin target protein [Monkeypox...

177

similar to VACV-COP-N2L, MPXV-ZAI96-P2L

Community Requests

Monkeypox virus

IDP01138
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4230

30258733

alpha-amylase

586

Drug Target Function

Phase 2: March 2008

1J0H

61%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP05122
(show subtarget assignments)

1

expressed

No

BA_3551

30258083

amyS

alpha-amylase [Bacillus anthracis str. A...

513

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1VJS

68.6%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05361
(show subtarget assignments)

1

cloned

No

BA_1162

30254880

alpha-amylase family protein [Bacillus a...

433

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1CYG

26.7%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02300
(show subtarget assignments)

1

soluble

No

GBAA1860

47527151

alpha/beta fold family hydrolase [Bacill...

307

Drug target motif; Involved in sporulation;

Phase 3: June 2008

3HJU

26.7%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP91995
(show subtarget assignments)

8

selected

No

SpneCM_010100003595

298254684

alpha-glycerophosphate oxidase (Glycerol...

608

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2RGO

62%

Streptococcus pneumoniae

IDP00567
(show subtarget assignments)

0

work_stopped

No

YPO1113

16121413

kgd

alpha-ketoglutarate decarboxylase

935

Virulence Associated Factor

Phase 2: March 2008

2JGD

87.8%

Yersinia pestis

Energy metabolism

TCA cycle

IDP05771
(show subtarget assignments)

1

cloned

No

Z0339

12513053

alpha replication protein of prophage CP...

777

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1KA8

9.5%

Escherichia coli

Mobile and extrachromosomal element functions: Prophage functions

IDP90907
(show subtarget assignments)

8

purified

No

STM0643

16764020

cobC

alpha ribazole-5'-P phosphatase [Salmone...

202

Predicted Essential

Community Requests

2P9Z

30.7%

Salmonella enterica

IDP90806
(show subtarget assignments)

8

crystallized

No

S0665

30062173

phpB

alpha-ribazole phosphatase [Shigella fle...

203

Predicted Essential

Community Requests

3HJG

28.4%

Shigella flexneri

IDP04246
(show subtarget assignments)

1

cloned

No

CPF_1362

110799745

aluminum resistance protein [Clostridium...

426

conserved gene; putative drug target function;

Phase 4: April 2009

3GWP

71.9%

Clostridium perfringens

Cellular processes

Detoxification