Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01352 (show subtarget assignments)	1	soluble	No	VCA0447	15601210		haemagglutinin associated protein	230	Conserved Gene / Pathway	Phase 2: March 2008	1G60	29.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01514 (show subtarget assignments)	1	purified	No	VCA0518	15601278		fructose-specific PTS IIA/HPr components...	400	Conserved Gene / Pathway	Phase 2: March 2008	1A3A	11.5%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04184 (show subtarget assignments)	1	expressed	No	VCA0522	15601282		sensor histidine kinase/response regulat...	686	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10.9%	Vibrio cholerae	Regulatory functions	Other

IDP04505 (show subtarget assignments)	1	soluble	No	VCA0531	15601291		sensor histidine kinase [Vibrio cholerae...	497	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.9%	Vibrio cholerae	Regulatory functions	Other

IDP04043 (show subtarget assignments)	1	soluble	No	VCA0565	15601324		sensor histidine kinase [Vibrio cholerae...	499	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BXD	6%	Vibrio cholerae	Regulatory functions	Other

IDP01488 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0572	15601331	ddl	D-alanyl-alanine synthetase A	334	Conserved Gene / Pathway	Phase 2: March 2008	2FB9	34.1%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01489 (show subtarget assignments)	1	cloned	No	VCA0591	15601350		peptide ABC transporter, periplasmic pep...	611	Conserved Gene / Pathway	Phase 2: March 2008	1ZTY	21.8%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01314 (show subtarget assignments)	1	cloned	No	VCA0594	15601353		hemolysin	93	Virulence Associated Factor	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01490 (show subtarget assignments)	1	expressed	No	VCA0602	15601360		ABC transporter, ATP-binding protein	403	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	34%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01491 (show subtarget assignments)	1	soluble	No	VCA0603	15601361		ABC transporter, periplasmic substrate-b...	339	Conserved Gene / Pathway	Phase 2: March 2008	1Y4T	18.3%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01353 (show subtarget assignments)	1	expressed	No	VCA0646	15601404		conserved hypothetical protein/hemolysin...	605	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP04185 (show subtarget assignments)	1	expressed	No	VCA0683	15601440		sensor protein UhpB [Vibrio cholerae O1 ...	527	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3GIG	12%	Vibrio cholerae	Regulatory functions	Other

IDP01341 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0687	15601444	fbpC	ferric transporter ATP-binding subunit	351	Conserved Gene / Pathway	Phase 2: March 2008	1V43	38.7%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01492 (show subtarget assignments)	1	purified	No	VCA0702	15601458		iron-containing alcohol dehydrogenase	382	Conserved Gene / Pathway	Phase 2: March 2008	1OJ7	50.8%	Vibrio cholerae	Energy metabolism	Fermentation

IDP04506 (show subtarget assignments)	1	cloned	No	VCA0719	15601475		sensor histide kinase [Vibrio cholerae O...	315	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	26.3%	Vibrio cholerae	Regulatory functions	Other

IDP04187 (show subtarget assignments)	1	expressed	No	VCA0723	15601479		3-hydroxy-3-methylglutaryl CoA reductase...	436	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1DQ8	35.5%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01311 (show subtarget assignments)	1	soluble	No	VCA0726	15601482		molybdenum ABC transporter, periplasmic ...	254	Conserved Gene / Pathway	Phase 2: March 2008	1AMF	37.8%	Vibrio cholerae	Transport and binding proteins	Anions

IDP01494 (show subtarget assignments)	1	purified	No	VCA0780	15601535		UDP-glucose 6-dehydrogenase	388	Conserved Gene / Pathway	Phase 2: March 2008	3PHL	71.1%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01520 (show subtarget assignments)	1	expressed	No	VCA0782	15601537		ABC transporter, ATP-binding protein	225	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	46.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01495 (show subtarget assignments)	1	cloned	No	VCA0803	15601558		serine protease, putative	330	Drug Target Function	Phase 2: March 2008	1BRU	24.2%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01496 (show subtarget assignments)	1	soluble	No	VCA0813	15601568		aminopeptidase	501	Drug Target Function	Phase 2: March 2008	1RTQ	43.9%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01312 (show subtarget assignments)	1	crystallized	No	VCA0819	15601574	groES	co-chaperonin GroES	96	Conserved Gene / Pathway	Phase 2: March 2008	1AON	65.6%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01497 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0820	15601575	groEL	chaperonin GroEL	530	Conserved Gene / Pathway	Phase 2: March 2008	1AON	74.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP04298 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0827	15601582	phhB	pterin-4-alpha-carbinolamine dehydratase...	109	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1RU0	33%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01515 (show subtarget assignments)	1	in_pdb 3ECT 3NZ2	Yes	VCA0836	15601591		hexapeptide-repeat containing-acetyltran...	192	Drug Target Function	Phase 2: March 2008	3ECT	100%	Vibrio cholerae	Central intermediary metabolism	Other

IDP04299 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0840	15601595		deoxycytidylate deaminase, putative [Vib...	161	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W4L	32.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP01498 (show subtarget assignments)	1	expressed	No	VCA0862	15601617		long-chain fatty acid transport protein ...	412	Conserved Gene / Pathway	Phase 2: March 2008	1T16	39.2%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00170 (show subtarget assignments)	1	soluble	No	VCA0865	15601620	hap	hemagglutinin/protease	609	Virulence	Phase 1: October 2007	1EZM	31.4%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01499 (show subtarget assignments)	1	cloned	No	VCA0870	15601625	pbpG	D-alanyl-D-alanine endopeptidase	316	Drug Target Function	Phase 2: March 2008	3IT9	27.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01324 (show subtarget assignments)	1	cloned	No	VCA0910	15601664		tonB1 protein	249	Conserved Gene / Pathway	Phase 2: March 2008	2GRX	27.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP04188 (show subtarget assignments)	1	expressed	No	VCA0939	15601692		sensory box/GGDEF family protein [Vibrio...	321	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3BRE	20.6%	Vibrio cholerae	Regulatory functions	Other

IDP01500 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0945	15601698	malE	maltose ABC transporter periplasmic prot...	406	Conserved Gene / Pathway	Phase 2: March 2008	3JYR	65%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01501 (show subtarget assignments)	1	expressed	No	VCA0946	15601699		maltose/maltodextrin transporter ATP-bin...	373	Conserved Gene / Pathway	Phase 2: March 2008	1Q12	67.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01326 (show subtarget assignments)	1	purified	No	VCA0953	15601706		peptidyl-prolyl cis-trans isomerase C	92	Conserved Gene / Pathway	Phase 2: March 2008	1JNS	65.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01502 (show subtarget assignments)	1	expressed	No	VCA0977	15601730		ABC transporter, ATP-binding protein	539	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	23.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01503 (show subtarget assignments)	1	soluble	No	VCA0978	15601731		amino acid ABC transporter, periplasmic ...	243	Conserved Gene / Pathway	Phase 2: March 2008	1HPB	26.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01325 (show subtarget assignments)	1	in_pdb 3EER 3I07 3LUS	Yes	VCA1006	15601759		organic hydroperoxide resistance protein...	145	Conserved Gene / Pathway	Phase 2: March 2008	3EER	100%	Vibrio cholerae	Cellular processes	Detoxification

IDP01344 (show subtarget assignments)	1	crystallized	No	VCA1025	15601778	nagB	glucosamine-6-phosphate deaminase	266	Drug Target Function	Phase 2: March 2008	1CD5	79.3%	Vibrio cholerae	Energy metabolism	Sugars

IDP01504 (show subtarget assignments)	1	expressed	No	VCA1028	15601781	lamB	maltoporin	416	Conserved Gene / Pathway	Phase 2: March 2008	1AF6	32.7%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01505 (show subtarget assignments)	1	expressed	No	VCA1037	15601788		amino acid ABC transporter, ATP-binding ...	239	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	52.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP90528 (show subtarget assignments)	8	cloned	No	VCA1063	15601814		ornithine decarboxylase [Vibrio cholerae...	720	Predicted Essential	Community Requests	1ORD	59.1%	Vibrio cholerae

IDP01506 (show subtarget assignments)	1	in_crystallization_trials	No	VCA1113	15601861		spermidine/putrescine ABC transporter, p...	343	Conserved Gene / Pathway	Phase 2: March 2008	1POT	37.6%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP91070 (show subtarget assignments)	8	cloned	No	RP205	15604078		multidrug resistance transporter ATM1 [R...	609	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	2HYD	32%	Rickettsia prowazekii

IDP90341 (show subtarget assignments)	8	expressed	No	CT049	15604768		hypothetical protein CT049 [Chlamydia tr...	490	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90339 (show subtarget assignments)	8	cloned	No	CT050	15604769		hypothetical protein CT050 [Chlamydia tr...	536	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3H0G	10.8%	Chlamydia trachomatis

IDP90356 (show subtarget assignments)	8	cloned	No	CT080	15604799	ltuB	late transcription unit B protein [Chlam...	97	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90323 (show subtarget assignments)	8	cloned	No	CT082	15604801		hypothetical protein CT082 [Chlamydia tr...	560	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90338 (show subtarget assignments)	8	cloned	No	CT087	15604806	malQ	4-alpha-glucanotransferase [Chlamydia tr...	527	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2X1I	25.2%	Chlamydia trachomatis

IDP90324 (show subtarget assignments)	8	expressed	No	CT088	15604807	sycE	secretion chaperone [Chlamydia trachomat...	146	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90325 (show subtarget assignments)	8	cloned	No	CT089	15604808	lcrE	low calcium response E [Chlamydia tracho...	421	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2VJ4	13.3%	Chlamydia trachomatis

IDP91183 (show subtarget assignments)	8	in_pdb 3T7Y	No	CT091	15604810	yscU	type III secretion system protein [Chlam...	360	virulence/pathogenesis / Targets that are in a network of interactions with CT670 and CT671. These protei...	Community Requests	3T7Y	26.7%	Chlamydia trachomatis

IDP90344 (show subtarget assignments)	8	cloned	No	CT105	15604824		hypothetical protein CT105 [Chlamydia tr...	656	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90343 (show subtarget assignments)	8	expressed	No	CT148	15604867	mhpA	FAD-dependent monooxygenase [Chlamydia t...	507	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90342 (show subtarget assignments)	8	expressed	No	CT155	15604874		phospholipase D endonuclease superfamily...	313	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90345 (show subtarget assignments)	8	cloned	No	CT157	15604876		phospholipase D endonuclease superfamily...	404	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1BYR	8.9%	Chlamydia trachomatis

IDP90351 (show subtarget assignments)	8	cloned	No	CT165	15604884		hypothetical protein CT165 [Chlamydia tr...	148	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90348 (show subtarget assignments)	8	expressed	No	CT166	15604885		hypothetical protein CT166 [Chlamydia tr...	639	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3SRZ	15.6%	Chlamydia trachomatis

IDP90353 (show subtarget assignments)	8	expressed	No	CT198	15604918	oppA_3	oligopeptide binding protein [Chlamydia ...	518	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1UIU	25.5%	Chlamydia trachomatis

IDP90347 (show subtarget assignments)	8	soluble	No	CT205	15604925	pfkA_1	diphosphate--fructose-6-phosphate 1-phos...	553	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KZH	36.9%	Chlamydia trachomatis

IDP90352 (show subtarget assignments)	8	expressed	No	CT262	15604983		hypothetical protein CT262 [Chlamydia tr...	256	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2CZL	32%	Chlamydia trachomatis

IDP90358 (show subtarget assignments)	8	expressed	No	CT273	15604994		hypothetical protein CT273 [Chlamydia tr...	188	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90346 (show subtarget assignments)	8	cloned	No	CT344	15605067	lon	ATP-dependent protease La [Chlamydia tra...	819	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3M6A	30.8%	Chlamydia trachomatis

IDP90350 (show subtarget assignments)	8	cloned	No	CT456	15605183		hypothetical protein CT456 [Chlamydia tr...	1005	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90349 (show subtarget assignments)	8	expressed	No	CT461	15605188	yaeI	phosphohydrolase [Chlamydia trachomatis ...	329	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP91180 (show subtarget assignments)	8	cloned	No	CT576	15605305	lcrH_1	low calcium response protein H [Chlamydi...	232	virulence/pathogenesis / Targets that are in a network of interactions with CT670 and CT671. These protei...	Community Requests	2VGX	19%	Chlamydia trachomatis

IDP90354 (show subtarget assignments)	8	purified	No	CT672	15605405	fliN	type III secretion system protein [Chlam...	373	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90355 (show subtarget assignments)	8	in_pdb 3N08	Yes	CT736	15605469	ybcL	hypothetical protein CT736 [Chlamydia tr...	150	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3N08	100%	Chlamydia trachomatis

IDP90359 (show subtarget assignments)	8	cloned	No	CT794.1	15605528		hypothetical protein CT794.1 [Chlamydia ...	95	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP91182 (show subtarget assignments)	8	expressed	No	CT862	15605598	lcrH_2	type III secretion chaperone [Chlamydia ...	198	virulence/pathogenesis / Targets that are in a network of interactions with CT670 and CT671. These protei...	Community Requests	2VGX	17.2%	Chlamydia trachomatis

IDP91090 (show subtarget assignments)	8	cloned	No	aq_1546	15606685	kpsF	polysialic acid capsule expression prote...	322	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	25.5%	Aquifex aeolicus

IDP91637 (show subtarget assignments)	8	cloned	No	NP_215056	15607682		O-succinylbenzoic acid--CoA ligase [Myco...	362	drug target / Potentially essential based on the transposon mutagenesis studies of Sassetti, C...	Community Requests	3NYQ	35%	Mycobacterium tuberculosis

IDP91643 (show subtarget assignments)	8	cloned	No	NP_215860	15608484		acyl carrier protein [Mycobacterium tube...	106	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	4DXE	19.8%	Mycobacterium tuberculosis

IDP91644 (show subtarget assignments)	8	purified	No	NP_215861	15608485		long-chain-fatty-acid--[acyl-carrier-pro...	521	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	3PBK	31.5%	Mycobacterium tuberculosis

IDP91645 (show subtarget assignments)	8	soluble	No	NP_215862	15608486		acyl-CoA dehydrogenase [Mycobacterium tu...	386	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	1WS9	27.2%	Mycobacterium tuberculosis

IDP91651 (show subtarget assignments)	8	cloned	No	NP_216894	15609515		lysine-N-oxygenase MBTG (L-lysine 6-mono...	431	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests			Mycobacterium tuberculosis

IDP91642 (show subtarget assignments)	8	cloned	No	NP_216895	15609516		peptide synthetase MBTF (peptide synthas...	1461	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	2VSQ	20.2%	Mycobacterium tuberculosis

IDP91639 (show subtarget assignments)	8	cloned	No	NP_216896	15609517		peptide synthetase MBTE (peptide synthas...	1682	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	2VSQ	17.7%	Mycobacterium tuberculosis

IDP91638 (show subtarget assignments)	8	expressed	No	NP_216897	15609518		polyketide synthetase MBTD (polyketide s...	1004	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	2HG4	15.5%	Mycobacterium tuberculosis

IDP91650 (show subtarget assignments)	8	cloned	No	NP_216898	15609519		polyketide synthetase MBTC (polyketide s...	444	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	2QO3	47.1%	Mycobacterium tuberculosis

IDP91641 (show subtarget assignments)	8	cloned	No	NP_216899	15609520		phenyloxazoline synthase MBTB (phenyloxa...	1414	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	2VSQ	23.6%	Mycobacterium tuberculosis

IDP91640 (show subtarget assignments)	8	cloned	No	NP_216900	15609521		bifunctional salicyl-AMP ligase/salicyl-...	565	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	1MD9	42.1%	Mycobacterium tuberculosis

IDP91649 (show subtarget assignments)	8	cloned	No	NP_217311	15609932		hypothetical protein Rv2795c [Mycobacter...	324	drug target / Confirmed essential by targeted genetic disruption and complementation studies, ...	Community Requests			Mycobacterium tuberculosis

IDP91636 (show subtarget assignments)	8	cloned	No	NP_217464	15610085		acyl-CoA synthetase [Mycobacterium tuber...	705	virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...	Community Requests	2V7B	23%	Mycobacterium tuberculosis

IDP91646 (show subtarget assignments)	8	purified	No	NP_217928	15610547		inosine 5'-monophosphate dehydrogenase [...	529	drug target / Potentially essential based on the transposon mutagenesis studies of Sassetti, C...	Community Requests	3TSB	50.3%	Mycobacterium tuberculosis

IDP91652 (show subtarget assignments)	8	purified	No	NP_218318	15610937		long-chain-fatty-acid--CoA ligase [Mycob...	637	drug target / Required for synthesis of mycolic acids and confirmed essential, see: Portevin, ...	Community Requests	3PBK	28.9%	Mycobacterium tuberculosis

IDP91075 (show subtarget assignments)	8	cloned	No	jhp0343	15611411	msbA	multi-drug resistance protein [Helicobac...	551	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5W	31.4%	Helicobacter pylori

IDP01354 (show subtarget assignments)	1	cloned	No	VC0003	15640035	trmE	tRNA modification GTPase TrmE	464	Conserved Gene / Pathway	Phase 2: March 2008	3GEH	37.9%	Vibrio cholerae	Cellular processes	Detoxification

IDP90504 (show subtarget assignments)	8	purified	No	VC0006	15640038	rnpA	ribonuclease P [Vibrio cholerae O1 biova...	118	Predicted Essential	Community Requests	2LJP	54.2%	Vibrio cholerae

IDP01355 (show subtarget assignments)	1	soluble	No	VC0008	15640040		amino acid ABC transporter, ATP-binding ...	245	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	51.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01356 (show subtarget assignments)	1	soluble	No	VC0010	15640042		amino acid ABC transporter, periplasmic ...	248	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	31.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP90614 (show subtarget assignments)	8	crystallized	No	VC0013	15640045		DNA polymerase III subunit beta [Vibrio ...	366	Predicted Essential	Community Requests	1MMI	63.9%	Vibrio cholerae

IDP90603 (show subtarget assignments)	8	selected	No	VC0015	15640047	gyrB	DNA gyrase subunit B [Vibrio cholerae O1...	805	Predicted Essential	Community Requests	1EI1	39.6%	Vibrio cholerae

IDP90920 (show subtarget assignments)	8	expressed	No	VC0021	15640053	glyQ	glycyl-tRNA synthetase subunit alpha [Vi...	330	Predicted Essential	Community Requests	3RF1	56.4%	Vibrio cholerae

IDP90604 (show subtarget assignments)	8	in_pdb 3Q0I	No	VC0045	15640077	fmt	methionyl-tRNA formyltransferase [Vibrio...	315	Predicted Essential	Community Requests	3Q0I	100%	Vibrio cholerae

IDP01357 (show subtarget assignments)	1	in_pdb 3FWX	Yes	VC0046	15640078	def	peptide deformylase	169	Conserved Gene / Pathway	Phase 2: March 2008	3FWX	100%	Vibrio cholerae	Protein fate	Protein modification and repair

IDP90792 (show subtarget assignments)	8	in_pdb 3PGJ 3O8Q 3SEF	Yes	VC0056	15640088	aroE	shikimate 5-dehydrogenase [Vibrio choler...	278	Predicted Essential	Community Requests	3O8Q	100%	Vibrio cholerae

IDP90563 (show subtarget assignments)	8	soluble	No	VC0061	15640093		thiamine biosynthesis protein ThiC [Vibr...	645	Predicted Essential	Community Requests	3EPM	65%	Vibrio cholerae

IDP90883 (show subtarget assignments)	8	soluble	No	VC0062	15640094	thiE	thiamine-phosphate pyrophosphorylase [Vi...	440	Predicted Essential	Community Requests	3O63	16.1%	Vibrio cholerae

IDP01358 (show subtarget assignments)	1	in_pdb 3QZ3	Yes	VC0078	15640110		ferritin	181	Conserved Gene / Pathway	Phase 2: March 2008	3QZ3	100%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP90584 (show subtarget assignments)	8	purified	No	VC0095	15640127		chorismate--pyruvate lyase [Vibrio chole...	183	Predicted Essential	Community Requests	1FW9	28.4%	Vibrio cholerae

IDP01352
(show subtarget assignments)

1

soluble

No

VCA0447

15601210

haemagglutinin associated protein

230

Conserved Gene / Pathway

Phase 2: March 2008

1G60

29.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01514
(show subtarget assignments)

1

purified

No

VCA0518

15601278

fructose-specific PTS IIA/HPr components...

400

Conserved Gene / Pathway

Phase 2: March 2008

1A3A

11.5%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04184
(show subtarget assignments)

1

expressed

No

VCA0522

15601282

sensor histidine kinase/response regulat...

686

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10.9%

Vibrio cholerae

Regulatory functions

Other

IDP04505
(show subtarget assignments)

1

soluble

No

VCA0531

15601291

sensor histidine kinase [Vibrio cholerae...

497

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.9%

Vibrio cholerae

Regulatory functions

Other

IDP04043
(show subtarget assignments)

1

soluble

No

VCA0565

15601324

sensor histidine kinase [Vibrio cholerae...

499

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BXD

6%

Vibrio cholerae

Regulatory functions

Other

IDP01488
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0572

15601331

ddl

D-alanyl-alanine synthetase A

334

Conserved Gene / Pathway

Phase 2: March 2008

2FB9

34.1%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01489
(show subtarget assignments)

1

cloned

No

VCA0591

15601350

peptide ABC transporter, periplasmic pep...

611

Conserved Gene / Pathway

Phase 2: March 2008

1ZTY

21.8%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01314
(show subtarget assignments)

1

cloned

No

VCA0594

15601353

hemolysin

93

Virulence Associated Factor

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01490
(show subtarget assignments)

1

expressed

No

VCA0602

15601360

ABC transporter, ATP-binding protein

403

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

34%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01491
(show subtarget assignments)

1

soluble

No

VCA0603

15601361

ABC transporter, periplasmic substrate-b...

339

Conserved Gene / Pathway

Phase 2: March 2008

1Y4T

18.3%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01353
(show subtarget assignments)

1

expressed

No

VCA0646

15601404

conserved hypothetical protein/hemolysin...

605

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP04185
(show subtarget assignments)

1

expressed

No

VCA0683

15601440

sensor protein UhpB [Vibrio cholerae O1 ...

527

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3GIG

12%

Vibrio cholerae

Regulatory functions

Other

IDP01341
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0687

15601444

fbpC

ferric transporter ATP-binding subunit

351

Conserved Gene / Pathway

Phase 2: March 2008

1V43

38.7%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01492
(show subtarget assignments)

1

purified

No

VCA0702

15601458

iron-containing alcohol dehydrogenase

382

Conserved Gene / Pathway

Phase 2: March 2008

1OJ7

50.8%

Vibrio cholerae

Energy metabolism

Fermentation

IDP04506
(show subtarget assignments)

1

cloned

No

VCA0719

15601475

sensor histide kinase [Vibrio cholerae O...

315

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

26.3%

Vibrio cholerae

Regulatory functions

Other

IDP04187
(show subtarget assignments)

1

expressed

No

VCA0723

15601479

3-hydroxy-3-methylglutaryl CoA reductase...

436

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1DQ8

35.5%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01311
(show subtarget assignments)

1

soluble

No

VCA0726

15601482

molybdenum ABC transporter, periplasmic ...

254

Conserved Gene / Pathway

Phase 2: March 2008

1AMF

37.8%

Vibrio cholerae

Transport and binding proteins

Anions

IDP01494
(show subtarget assignments)

1

purified

No

VCA0780

15601535

UDP-glucose 6-dehydrogenase

388

Conserved Gene / Pathway

Phase 2: March 2008

3PHL

71.1%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01520
(show subtarget assignments)

1

expressed

No

VCA0782

15601537

ABC transporter, ATP-binding protein

225

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

46.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01495
(show subtarget assignments)

1

cloned

No

VCA0803

15601558

serine protease, putative

330

Drug Target Function

Phase 2: March 2008

1BRU

24.2%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01496
(show subtarget assignments)

1

soluble

No

VCA0813

15601568

aminopeptidase

501

Drug Target Function

Phase 2: March 2008

1RTQ

43.9%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01312
(show subtarget assignments)

1

crystallized

No

VCA0819

15601574

groES

co-chaperonin GroES

96

Conserved Gene / Pathway

Phase 2: March 2008

1AON

65.6%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01497
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0820

15601575

groEL

chaperonin GroEL

530

Conserved Gene / Pathway

Phase 2: March 2008

1AON

74.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP04298
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0827

15601582

phhB

pterin-4-alpha-carbinolamine dehydratase...

109

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1RU0

33%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01515
(show subtarget assignments)

1

in_pdb
3ECT
3NZ2

Yes

VCA0836

15601591

hexapeptide-repeat containing-acetyltran...

192

Drug Target Function

Phase 2: March 2008

3ECT

100%

Vibrio cholerae

Central intermediary metabolism

Other

IDP04299
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0840

15601595

deoxycytidylate deaminase, putative [Vib...

161

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W4L

32.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP01498
(show subtarget assignments)

1

expressed

No

VCA0862

15601617

long-chain fatty acid transport protein ...

412

Conserved Gene / Pathway

Phase 2: March 2008

1T16

39.2%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00170
(show subtarget assignments)

1

soluble

No

VCA0865

15601620

hap

hemagglutinin/protease

609

Virulence

Phase 1: October 2007

1EZM

31.4%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01499
(show subtarget assignments)

1

cloned

No

VCA0870

15601625

pbpG

D-alanyl-D-alanine endopeptidase

316

Drug Target Function

Phase 2: March 2008

3IT9

27.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01324
(show subtarget assignments)

1

cloned

No

VCA0910

15601664

tonB1 protein

249

Conserved Gene / Pathway

Phase 2: March 2008

2GRX

27.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP04188
(show subtarget assignments)

1

expressed

No

VCA0939

15601692

sensory box/GGDEF family protein [Vibrio...

321

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3BRE

20.6%

Vibrio cholerae

Regulatory functions

Other

IDP01500
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0945

15601698

malE

maltose ABC transporter periplasmic prot...

406

Conserved Gene / Pathway

Phase 2: March 2008

3JYR

65%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01501
(show subtarget assignments)

1

expressed

No

VCA0946

15601699

maltose/maltodextrin transporter ATP-bin...

373

Conserved Gene / Pathway

Phase 2: March 2008

1Q12

67.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01326
(show subtarget assignments)

1

purified

No

VCA0953

15601706

peptidyl-prolyl cis-trans isomerase C

92

Conserved Gene / Pathway

Phase 2: March 2008

1JNS

65.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01502
(show subtarget assignments)

1

expressed

No

VCA0977

15601730

ABC transporter, ATP-binding protein

539

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

23.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01503
(show subtarget assignments)

1

soluble

No

VCA0978

15601731

amino acid ABC transporter, periplasmic ...

243

Conserved Gene / Pathway

Phase 2: March 2008

1HPB

26.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01325
(show subtarget assignments)

1

in_pdb
3EER
3I07
3LUS

Yes

VCA1006

15601759

organic hydroperoxide resistance protein...

145

Conserved Gene / Pathway

Phase 2: March 2008

3EER

100%

Vibrio cholerae

Cellular processes

Detoxification

IDP01344
(show subtarget assignments)

1

crystallized

No

VCA1025

15601778

nagB

glucosamine-6-phosphate deaminase

266

Drug Target Function

Phase 2: March 2008

1CD5

79.3%

Vibrio cholerae

Energy metabolism

Sugars

IDP01504
(show subtarget assignments)

1

expressed

No

VCA1028

15601781

lamB

maltoporin

416

Conserved Gene / Pathway

Phase 2: March 2008

1AF6

32.7%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01505
(show subtarget assignments)

1

expressed

No

VCA1037

15601788

amino acid ABC transporter, ATP-binding ...

239

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

52.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP90528
(show subtarget assignments)

8

cloned

No

VCA1063

15601814

ornithine decarboxylase [Vibrio cholerae...

720

Predicted Essential

Community Requests

1ORD

59.1%

Vibrio cholerae

IDP01506
(show subtarget assignments)

1

in_crystallization_trials

No

VCA1113

15601861

spermidine/putrescine ABC transporter, p...

343

Conserved Gene / Pathway

Phase 2: March 2008

1POT

37.6%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP91070
(show subtarget assignments)

8

cloned

No

RP205

15604078

multidrug resistance transporter ATM1 [R...

609

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

2HYD

32%

Rickettsia prowazekii

IDP90341
(show subtarget assignments)

8

expressed

No

CT049

15604768

hypothetical protein CT049 [Chlamydia tr...

490

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90339
(show subtarget assignments)

8

cloned

No

CT050

15604769

hypothetical protein CT050 [Chlamydia tr...

536

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3H0G

10.8%

Chlamydia trachomatis

IDP90356
(show subtarget assignments)

8

cloned

No

CT080

15604799

ltuB

late transcription unit B protein [Chlam...

97

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90323
(show subtarget assignments)

8

cloned

No

CT082

15604801

hypothetical protein CT082 [Chlamydia tr...

560

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90338
(show subtarget assignments)

8

cloned

No

CT087

15604806

malQ

4-alpha-glucanotransferase [Chlamydia tr...

527

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2X1I

25.2%

Chlamydia trachomatis

IDP90324
(show subtarget assignments)

8

expressed

No

CT088

15604807

sycE

secretion chaperone [Chlamydia trachomat...

146

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90325
(show subtarget assignments)

8

cloned

No

CT089

15604808

lcrE

low calcium response E [Chlamydia tracho...

421

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2VJ4

13.3%

Chlamydia trachomatis

IDP91183
(show subtarget assignments)

8

in_pdb
3T7Y

No

CT091

15604810

yscU

type III secretion system protein [Chlam...

360

virulence/pathogenesis / Targets that are in a network of interactions with CT670 and CT671. These protei...

Community Requests

3T7Y

26.7%

Chlamydia trachomatis

IDP90344
(show subtarget assignments)

8

cloned

No

CT105

15604824

hypothetical protein CT105 [Chlamydia tr...

656

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90343
(show subtarget assignments)

8

expressed

No

CT148

15604867

mhpA

FAD-dependent monooxygenase [Chlamydia t...

507

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90342
(show subtarget assignments)

8

expressed

No

CT155

15604874

phospholipase D endonuclease superfamily...

313

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90345
(show subtarget assignments)

8

cloned

No

CT157

15604876

phospholipase D endonuclease superfamily...

404

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1BYR

8.9%

Chlamydia trachomatis

IDP90351
(show subtarget assignments)

8

cloned

No

CT165

15604884

hypothetical protein CT165 [Chlamydia tr...

148

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90348
(show subtarget assignments)

8

expressed

No

CT166

15604885

hypothetical protein CT166 [Chlamydia tr...

639

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3SRZ

15.6%

Chlamydia trachomatis

IDP90353
(show subtarget assignments)

8

expressed

No

CT198

15604918

oppA_3

oligopeptide binding protein [Chlamydia ...

518

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1UIU

25.5%

Chlamydia trachomatis

IDP90347
(show subtarget assignments)

8

soluble

No

CT205

15604925

pfkA_1

diphosphate--fructose-6-phosphate 1-phos...

553

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KZH

36.9%

Chlamydia trachomatis

IDP90352
(show subtarget assignments)

8

expressed

No

CT262

15604983

hypothetical protein CT262 [Chlamydia tr...

256

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2CZL

32%

Chlamydia trachomatis

IDP90358
(show subtarget assignments)

8

expressed

No

CT273

15604994

hypothetical protein CT273 [Chlamydia tr...

188

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90346
(show subtarget assignments)

8

cloned

No

CT344

15605067

lon

ATP-dependent protease La [Chlamydia tra...

819

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3M6A

30.8%

Chlamydia trachomatis

IDP90350
(show subtarget assignments)

8

cloned

No

CT456

15605183

hypothetical protein CT456 [Chlamydia tr...

1005

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90349
(show subtarget assignments)

8

expressed

No

CT461

15605188

yaeI

phosphohydrolase [Chlamydia trachomatis ...

329

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP91180
(show subtarget assignments)

8

cloned

No

CT576

15605305

lcrH_1

low calcium response protein H [Chlamydi...

232

virulence/pathogenesis / Targets that are in a network of interactions with CT670 and CT671. These protei...

Community Requests

2VGX

19%

Chlamydia trachomatis

IDP90354
(show subtarget assignments)

8

purified

No

CT672

15605405

fliN

type III secretion system protein [Chlam...

373

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90355
(show subtarget assignments)

8

in_pdb
3N08

Yes

CT736

15605469

ybcL

hypothetical protein CT736 [Chlamydia tr...

150

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3N08

100%

Chlamydia trachomatis

IDP90359
(show subtarget assignments)

8

cloned

No

CT794.1

15605528

hypothetical protein CT794.1 [Chlamydia ...

95

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP91182
(show subtarget assignments)

8

expressed

No

CT862

15605598

lcrH_2

type III secretion chaperone [Chlamydia ...

198

virulence/pathogenesis / Targets that are in a network of interactions with CT670 and CT671. These protei...

Community Requests

2VGX

17.2%

Chlamydia trachomatis

IDP91090
(show subtarget assignments)

8

cloned

No

aq_1546

15606685

kpsF

polysialic acid capsule expression prote...

322

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

25.5%

Aquifex aeolicus

IDP91637
(show subtarget assignments)

8

cloned

No

NP_215056

15607682

O-succinylbenzoic acid--CoA ligase [Myco...

362

drug target / Potentially essential based on the transposon mutagenesis studies of Sassetti, C...

Community Requests

3NYQ

35%

Mycobacterium tuberculosis

IDP91643
(show subtarget assignments)

8

cloned

No

NP_215860

15608484

acyl carrier protein [Mycobacterium tube...

106

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

4DXE

19.8%

Mycobacterium tuberculosis

IDP91644
(show subtarget assignments)

8

purified

No

NP_215861

15608485

long-chain-fatty-acid--[acyl-carrier-pro...

521

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

3PBK

31.5%

Mycobacterium tuberculosis

IDP91645
(show subtarget assignments)

8

soluble

No

NP_215862

15608486

acyl-CoA dehydrogenase [Mycobacterium tu...

386

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

1WS9

27.2%

Mycobacterium tuberculosis

IDP91651
(show subtarget assignments)

8

cloned

No

NP_216894

15609515

lysine-N-oxygenase MBTG (L-lysine 6-mono...

431

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

Mycobacterium tuberculosis

IDP91642
(show subtarget assignments)

8

cloned

No

NP_216895

15609516

peptide synthetase MBTF (peptide synthas...

1461

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

2VSQ

20.2%

Mycobacterium tuberculosis

IDP91639
(show subtarget assignments)

8

cloned

No

NP_216896

15609517

peptide synthetase MBTE (peptide synthas...

1682

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

2VSQ

17.7%

Mycobacterium tuberculosis

IDP91638
(show subtarget assignments)

8

expressed

No

NP_216897

15609518

polyketide synthetase MBTD (polyketide s...

1004

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

2HG4

15.5%

Mycobacterium tuberculosis

IDP91650
(show subtarget assignments)

8

cloned

No

NP_216898

15609519

polyketide synthetase MBTC (polyketide s...

444

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

2QO3

47.1%

Mycobacterium tuberculosis

IDP91641
(show subtarget assignments)

8

cloned

No

NP_216899

15609520

phenyloxazoline synthase MBTB (phenyloxa...

1414

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

2VSQ

23.6%

Mycobacterium tuberculosis

IDP91640
(show subtarget assignments)

8

cloned

No

NP_216900

15609521

bifunctional salicyl-AMP ligase/salicyl-...

565

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

1MD9

42.1%

Mycobacterium tuberculosis

IDP91649
(show subtarget assignments)

8

cloned

No

NP_217311

15609932

hypothetical protein Rv2795c [Mycobacter...

324

drug target / Confirmed essential by targeted genetic disruption and complementation studies, ...

Community Requests

Mycobacterium tuberculosis

IDP91636
(show subtarget assignments)

8

cloned

No

NP_217464

15610085

acyl-CoA synthetase [Mycobacterium tuber...

705

virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...

Community Requests

2V7B

23%

Mycobacterium tuberculosis

IDP91646
(show subtarget assignments)

8

purified

No

NP_217928

15610547

inosine 5'-monophosphate dehydrogenase [...

529

drug target / Potentially essential based on the transposon mutagenesis studies of Sassetti, C...

Community Requests

3TSB

50.3%

Mycobacterium tuberculosis

IDP91652
(show subtarget assignments)

8

purified

No

NP_218318

15610937

long-chain-fatty-acid--CoA ligase [Mycob...

637

drug target / Required for synthesis of mycolic acids and confirmed essential, see: Portevin, ...

Community Requests

3PBK

28.9%

Mycobacterium tuberculosis

IDP91075
(show subtarget assignments)

8

cloned

No

jhp0343

15611411

msbA

multi-drug resistance protein [Helicobac...

551

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5W

31.4%

Helicobacter pylori

IDP01354
(show subtarget assignments)

1

cloned

No

VC0003

15640035

trmE

tRNA modification GTPase TrmE

464

Conserved Gene / Pathway

Phase 2: March 2008

3GEH

37.9%

Vibrio cholerae

Cellular processes

Detoxification

IDP90504
(show subtarget assignments)

8

purified

No

VC0006

15640038

rnpA

ribonuclease P [Vibrio cholerae O1 biova...

118

Predicted Essential

Community Requests

2LJP

54.2%

Vibrio cholerae

IDP01355
(show subtarget assignments)

1

soluble

No

VC0008

15640040

amino acid ABC transporter, ATP-binding ...

245

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

51.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01356
(show subtarget assignments)

1

soluble

No

VC0010

15640042

amino acid ABC transporter, periplasmic ...

248

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

31.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP90614
(show subtarget assignments)

8

crystallized

No

VC0013

15640045

DNA polymerase III subunit beta [Vibrio ...

366

Predicted Essential

Community Requests

1MMI

63.9%

Vibrio cholerae

IDP90603
(show subtarget assignments)

8

selected

No

VC0015

15640047

gyrB

DNA gyrase subunit B [Vibrio cholerae O1...

805

Predicted Essential

Community Requests

1EI1

39.6%

Vibrio cholerae

IDP90920
(show subtarget assignments)

8

expressed

No

VC0021

15640053

glyQ

glycyl-tRNA synthetase subunit alpha [Vi...

330

Predicted Essential

Community Requests

3RF1

56.4%

Vibrio cholerae

IDP90604
(show subtarget assignments)

8

in_pdb
3Q0I

No

VC0045

15640077

fmt

methionyl-tRNA formyltransferase [Vibrio...

315

Predicted Essential

Community Requests

3Q0I

100%

Vibrio cholerae

IDP01357
(show subtarget assignments)

1

in_pdb
3FWX

Yes

VC0046

15640078

def

peptide deformylase

169

Conserved Gene / Pathway

Phase 2: March 2008

3FWX

100%

Vibrio cholerae

Protein fate

Protein modification and repair

IDP90792
(show subtarget assignments)

8

in_pdb
3PGJ
3O8Q
3SEF

Yes

VC0056

15640088

aroE

shikimate 5-dehydrogenase [Vibrio choler...

278

Predicted Essential

Community Requests

3O8Q

100%

Vibrio cholerae

IDP90563
(show subtarget assignments)

8

soluble

No

VC0061

15640093

thiamine biosynthesis protein ThiC [Vibr...

645

Predicted Essential

Community Requests

3EPM

65%

Vibrio cholerae

IDP90883
(show subtarget assignments)

8

soluble

No

VC0062

15640094

thiE

thiamine-phosphate pyrophosphorylase [Vi...

440

Predicted Essential

Community Requests

3O63

16.1%

Vibrio cholerae

IDP01358
(show subtarget assignments)

1

in_pdb
3QZ3

Yes

VC0078

15640110

ferritin

181

Conserved Gene / Pathway

Phase 2: March 2008

3QZ3

100%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP90584
(show subtarget assignments)

8

purified

No

VC0095

15640127

chorismate--pyruvate lyase [Vibrio chole...

183

Predicted Essential

Community Requests

1FW9

28.4%

Vibrio cholerae