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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP90634
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO3403
16123552
panD
aspartate alpha-decarboxylase [Yersinia ...
126
Predicted Essential
Community Requests
1PPY
78.6%
Yersinia pestis
IDP00113
(
show subtarget assignments
)
0
work_stopped
No
NT01SAA0015
16119212
blaI
PENICILLINASE REPRESSOR
126
Virulence
Phase 1: October 2007
1SD4
100%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP00407
(
show subtarget assignments
)
1
purified
No
YPO2929
16123116
acpS
4'-phosphopantetheinyl transferase
126
Virulence Associated Factor
Phase 2: March 2008
3H88
53.2%
Yersinia pestis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP90144
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_189.5
68449261
bifunctional IL-1-beta-inhibitor/prevent...
126
contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184
Community Requests
1G0Y
27.8%
Monkeypox virus
IDP05767
(
show subtarget assignments
)
1
soluble
No
S2798
30042221
acpS
CoA:apo-[acyl-carrier-protein] pantethei...
126
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3H88
55.6%
Shigella flexneri
Fatty acid and phospholipid metabolism: Biosynthesis
IDP90177
(
show subtarget assignments
)
8
expressed
No
AAM13471.1
20153010
CPXV024 CDS
CPXV024 protein
126
Orthopoxvirus interleukin 18 binding protein; plays a key role in the activation...
Community Requests
3F62
80.2%
Cowpox virus
host defense modulator
0
IDP05615
(
show subtarget assignments
)
1
soluble
No
BA_5522
30259982
putative lipoprotein [Bacillus anthracis...
126
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP05441
(
show subtarget assignments
)
1
soluble
No
lmo2809
16804846
-
hypothetical protein lmo2809 [Listeria m...
113
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP05422
(
show subtarget assignments
)
1
soluble
No
BA_1872
30256537
putative lipoprotein [Bacillus anthracis...
126
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP91510
(
show subtarget assignments
)
8
cloned
No
VP1664
28898438
putative type III secretion protein [Vib...
126
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP92248
(
show subtarget assignments
)
8
selected
No
FTN_1133
118497723
hypothetical protein FTN_1133 [Francisel...
127
virulence/pathogenesis /
We recently described FTN_1133/FTL_0803/FTT_1152 as an important virulence facto...
Community Requests
Francisella novicida
IDP92144
(
show subtarget assignments
)
8
selected
No
TGME49_110960
211962004
vacuolar ATP synthase subunit F, putativ...
127
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2QAI
22%
Toxoplasma gondii
IDP92249
(
show subtarget assignments
)
8
selected
No
FTT_1152
56604715
hypothetical protein [Francisella tulare...
127
virulence/pathogenesis /
We recently described FTN_1133/FTL_0803/FTT_1152 as an important virulence facto...
Community Requests
Francisella tularensis
IDP02295
(
show subtarget assignments
)
1
cloned
No
FTT1212c
56708274
gloA
lactoylglutathione lyase [Francisella tu...
127
Drug Target
Phase 3: June 2008
1F9Z
56.7%
Francisella tularensis
Energy metabolism
Other
IDP91730
(
show subtarget assignments
)
8
selected
No
NP_683513
22538811
CCL28
C-C motif chemokine 28 precursor [Homo s...
127
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2KUM
22.8%
Homo sapiens
IDP92250
(
show subtarget assignments
)
8
selected
No
FTL_0803
89256173
hypothetical protein FTL_0803 [Francisel...
127
virulence/pathogenesis /
We recently described FTN_1133/FTL_0803/FTT_1152 as an important virulence facto...
Community Requests
Francisella tularensis
IDP04342
(
show subtarget assignments
)
1
cloned
No
GBAA1564
47526837
panD
aspartate alpha-decarboxylase [Bacillus ...
127
conserved gene; putative drug target function;
Phase 4: April 2009
2C45
52.3%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers
Pantothenate and coenzyme A
IDP01989
(
show subtarget assignments
)
1
purified
No
STM2646
16765966
yfiD
autonomous glycyl radical cofactor GrcA ...
127
Conserved; Drug target functions
Phase 3: June 2008
1CM5
38.6%
Salmonella enterica
Energy metabolism
Anaerobic
IDP00329
(
show subtarget assignments
)
1
cloned
No
Cj1724c
15793027
7-cyano-7-deazaguanine reductase
127
Drug Target Function
Phase 2: March 2008
Campylobacter jejuni
Amino acid biosynthesis
Pyruvate family
IDP02185
(
show subtarget assignments
)
1
selected
No
FTT0408
56707557
gcvH
glycine cleavage system H protein [Franc...
127
Drug Target
Phase 3: June 2008
3A7A
59.8%
Francisella tularensis
Energy metabolism
Amino acids and amines
IDP05483
(
show subtarget assignments
)
1
soluble
No
BA_3005
30257593
putative lipoprotein [Bacillus anthracis...
128
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP00500
(
show subtarget assignments
)
1
purified
No
YPO1784
16122038
putative copper resistance protein
128
Conserved Gene / Pathway
Phase 2: March 2008
1IX2
31.2%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP91930
(
show subtarget assignments
)
8
selected
No
SPH_0573
169834046
hypothetical protein SPH_0573 [Streptoco...
128
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP02571
(
show subtarget assignments
)
1
expressed
No
Cj0549
15791910
fliS
flagellar protein FliS [Campylobacter je...
128
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
3IQC
58.6%
Campylobacter jejuni
Cell envelope
Other
IDP04008
(
show subtarget assignments
)
1
cloned
No
YPO0906
218928079
gcsH
glycine cleavage system protein H [Yersi...
128
conserved gene; putative drug target function;
Phase 4: April 2009
3A7A
75%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP00879
(
show subtarget assignments
)
1
purified
No
STM0211
16763601
yaeH
putative cytoplasmic protein
128
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP02308
(
show subtarget assignments
)
1
expressed
No
FTT1400c
56708448
hypothetical protein FTT1400c [Francisel...
128
Drug Target
Phase 3: June 2008
Francisella tularensis
Unclassified
Role category not yet assigned
IDP05360
(
show subtarget assignments
)
1
cloned
No
BA_1623
30255921
rnhA
ribonuclease H [Bacillus anthracis str. ...
128
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3U3G
33.8%
Bacillus anthracis
Transcription: Degradation of RNA
IDP91404
(
show subtarget assignments
)
8
soluble
No
VV1_0879
27364327
ribosome-associated heat shock protein i...
128
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1DM9
64.8%
Vibrio vulnificus
IDP91387
(
show subtarget assignments
)
8
in_pdb
3VCZ
No
VV1_1463
27364847
putative translation initiation inhibito...
129
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3VCZ
100%
Vibrio vulnificus
IDP01380
(
show subtarget assignments
)
1
in_pdb
3O1K
Yes
VC0524
15640546
dihydroneopterin aldolase FolB, putative...
129
Conserved Gene / Pathway
Phase 2: March 2008
3O1K
100%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Folic acid
IDP01029
(
show subtarget assignments
)
0
work_stopped
No
STM1916
16765258
cheY
chemotaxis regulator transmitting signal...
129
Conserved Gene / Pathway
Phase 2: March 2008
2FKA
100%
Salmonella enterica
Cellular processes
Other
IDP04118
(
show subtarget assignments
)
1
cloned
No
YPCD1.22c
5832443
YPCD1.22c
hypothetical protein YPCD1.22c [Yersinia...
129
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP05418
(
show subtarget assignments
)
1
soluble
No
BA_1561
30255862
conserved hypothetical protein [Bacillus...
129
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP04590
(
show subtarget assignments
)
1
expressed
No
BAS0136
49183170
30S ribosomal protein S11 [Bacillus anth...
129
Proposed to be essential proteins
Phase 4: April 2009
1VS5
65.9%
Bacillus anthracis
IDP01980
(
show subtarget assignments
)
0
work_stopped
No
STM3054
16766355
gcvH
glycine cleavage system protein H [Salmo...
129
Conserved; Drug target functions
Phase 3: June 2008
3A8I
98.5%
Salmonella enterica
Energy metabolism
Amino acids and amines
IDP91669
(
show subtarget assignments
)
8
selected
No
AGSK1_HUMAN
0
129
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
Homo sapiens
IDP05612
(
show subtarget assignments
)
1
soluble
No
BA_5233
30259713
putative lipoprotein [Bacillus anthracis...
129
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP04002
(
show subtarget assignments
)
8
selected
No
CAC05806
12329075
ipgA
IpgA, similarities to IpgE, putative cha...
129
Shigella effector protein
Community Requests
Shigella flexneri
IDP02402
(
show subtarget assignments
)
1
purified
No
FTT1778c
56708771
hypothetical protein FTT1778c [Francisel...
130
Drug Target
Phase 3: June 2008
Francisella tularensis
Cell envelope
Other
IDP04593
(
show subtarget assignments
)
1
cloned
No
BAS0144
49183178
30S ribosomal protein S9 [Bacillus anthr...
130
Proposed to be essential proteins
Phase 4: April 2009
1VS5
55.4%
Bacillus anthracis
IDP90330
(
show subtarget assignments
)
8
expressed
No
CT_602
3329047
hypothetical protein [Chlamydia trachoma...
130
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP02819
(
show subtarget assignments
)
1
expressed
No
STM2414
16765738
yfeD
putative negative regulator [Salmonella ...
130
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP05513
(
show subtarget assignments
)
1
cloned
No
CD0278
126697850
putative transcriptional regulator [Clos...
130
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
4A5M
34.6%
Clostridium difficile
Regulatory functions: DNA interactions
IDP05240
(
show subtarget assignments
)
1
expressed
No
CD0233
126697804
hypothetical protein CD0233 [Clostridium...
130
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2AJ7
33.1%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP05188
(
show subtarget assignments
)
1
purified
No
CD0235
126697806
fliS1
flagellar protein FliS [Clostridium diff...
131
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1VH6
29.8%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP02283
(
show subtarget assignments
)
1
in_crystallization_trials
No
lmo0062
16802110
hypothetical protein lmo0062 [Listeria m...
131
Predicted virulence-Type III; Type IV; ESAT secretion systems
Phase 3: June 2008
Listeria monocytogenes
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP00404
(
show subtarget assignments
)
1
soluble
No
YPCD1.48
16082736
virG
needle complex outer membrane lipoprotei...
131
Virulence Associated Factor
Phase 2: March 2008
2YJL
23.7%
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP05045
(
show subtarget assignments
)
1
soluble
No
BA_3418
30257959
putative lipoprotein [Bacillus anthracis...
131
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP05450
(
show subtarget assignments
)
1
cloned
No
lmo2776
16804813
-
hypothetical protein lmo2776 [Listeria m...
131
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP91461
(
show subtarget assignments
)
8
in_crystallization_trials
No
VV1_0087
27363571
Phage protein U [Vibrio vulnificus CMCP6...
131
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP00031
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_1078
30254808
blaI
penicillinase repressor
132
Virulence
Phase 1: October 2007
1OKR
35.6%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP04295
(
show subtarget assignments
)
1
cloned
No
FTT0031
56707211
nuoA
NADH dehydrogenase I, A subunit [Francis...
132
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3RKO
33.3%
Francisella tularensis
Energy metabolism
Electron transport
IDP05570
(
show subtarget assignments
)
1
expressed
No
BAS5100
49188086
-
hypothetical protein BAS5100 [Bacillus a...
132
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP91003
(
show subtarget assignments
)
8
soluble
No
y1934
22125826
sufA
iron-sulfur cluster assembly scaffold pr...
132
potential drug target /
part of iron-sulfur cluster assembly system active under stress conditions
Community Requests
2D2A
59.8%
Yersinia pestis
IDP04050
(
show subtarget assignments
)
1
purified
No
YPO1765
218928887
hpaF
5-carboxymethyl-2-hydroxymuconate delta-...
132
conserved gene; putative drug target function;
Phase 4: April 2009
1OTG
67.4%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP04106
(
show subtarget assignments
)
1
cloned
No
BAS0124
49183158
30S ribosomal protein S8 [Bacillus anthr...
132
Proposed to be essential proteins
Phase 4: April 2009
1SEI
85.6%
Bacillus anthracis
IDP04016
(
show subtarget assignments
)
1
in_crystallization_trials
No
CPF_0834
110798754
arsC
arsenate reductase ArsC [Clostridium per...
132
conserved gene; putative drug target function;
Phase 4: April 2009
2L17
40.9%
Clostridium perfringens
Cellular processes
Detoxification
IDP02577
(
show subtarget assignments
)
1
purified
No
GBAA5546
47530866
atpC
F0F1 ATP synthase subunit epsilon [Bacil...
133
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
2E5Y
69.9%
Bacillus anthracis
Energy metabolism
ATP-proton motive force interconversion
IDP05560
(
show subtarget assignments
)
1
soluble
No
BAS2951
49185956
-
hypothetical protein BAS2951 [Bacillus a...
133
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP00233
(
show subtarget assignments
)
1
cloned
No
YPO3676
16123819
-
putative phage-related protein
133
Virulence
Phase 1: October 2007
2VO9
25.6%
Yersinia pestis
Hypothetical proteins
Conserved
IDP02078
(
show subtarget assignments
)
1
expressed
No
YPO0268
16120606
type III secretion system apparatus prot...
133
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP01031
(
show subtarget assignments
)
0
work_stopped
No
STM3497
16766785
yrfH
ribosome-associated heat shock protein H...
133
Conserved Gene / Pathway
Phase 2: March 2008
1DM9
95.5%
Salmonella enterica
Protein synthesis
Other
IDP00090
(
show subtarget assignments
)
1
crystallized
No
NT01SF0319
30040101
crl
transcriptional regulator of cryptic csg...
133
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3RPJ
45.9%
Shigella flexneri
Cell envelope
Surface structures
IDP05274
(
show subtarget assignments
)
1
soluble
No
lmo1880
16803919
-
hypothetical protein lmo1880 [Listeria m...
133
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1JL2
33.8%
Listeria monocytogenes
Transcription: Degradation of RNA
IDP01708
(
show subtarget assignments
)
1
expressed
No
Cj0241c
15791613
putative iron-binding protein [Campyloba...
133
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
2AVK
26.3%
Campylobacter jejuni
Cellular processes
Other
IDP91421
(
show subtarget assignments
)
8
soluble
No
VV1_0568
27364030
NTP pyrophosphohydrolase [Vibrio vulnifi...
133
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1MUT
42.9%
Vibrio vulnificus
IDP90410
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_663
3329114
hypothetical protein [Chlamydia trachoma...
133
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00627
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL0552
57285570
hypothetical protein SACOL0552
133
Conserved Gene / Pathway
Phase 2: March 2008
2K4K
40.6%
Staphylococcus aureus
Cellular processes
Adaptations to atypical conditions
IDP05473
(
show subtarget assignments
)
1
expressed
No
BA_2626
30257243
hypothetical protein BA_2626 [Bacillus a...
134
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP00213
(
show subtarget assignments
)
1
soluble
No
YPO0628
16120954
-
putative translational inhibitor protein...
134
Virulence
Phase 1: October 2007
3I7T
35.1%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP92002
(
show subtarget assignments
)
8
selected
No
SpneCM_010100000145
298254010
competence protein CglD [Streptococcus p...
134
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP91661
(
show subtarget assignments
)
8
selected
No
NP_002980
4506835
CCL21
C-C motif chemokine 21 precursor [Homo s...
134
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2L4N
82.8%
Homo sapiens
IDP91356
(
show subtarget assignments
)
8
cloned
No
VV1_2923
27366200
DNA-binding protein H-NS [Vibrio vulnifi...
135
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1OV9
31.1%
Vibrio vulnificus
IDP02678
(
show subtarget assignments
)
1
cloned
No
FTT1653
56708665
hypothetical protein FTT1653 [Francisell...
135
Drug Target
Phase 3: June 2008
Francisella tularensis
Cell envelope
Other
IDP90396
(
show subtarget assignments
)
8
soluble
No
CT_552
3328992
hypothetical protein [Chlamydia trachoma...
135
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91479
(
show subtarget assignments
)
8
expressed
No
VPA1331
28901186
putative OspC2 [Vibrio parahaemolyticus ...
135
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP05661
(
show subtarget assignments
)
1
in_crystallization_trials
No
lmo0240
16802286
-
hypothetical protein lmo0240 [Listeria m...
136
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1U61
52.2%
Listeria monocytogenes
Protein synthesis: tRNA aminoacylation
IDP91462
(
show subtarget assignments
)
8
cloned
No
VV1_0089
27363573
hypothetical protein VV1_0089 [Vibrio vu...
136
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP00319
(
show subtarget assignments
)
1
expressed
No
CBU_2070
29655348
chorismate mutase, putative
136
Drug Target Function
Phase 2: March 2008
Coxiella burnetii
Amino acid biosynthesis
Aromatic amino acid family
IDP02409
(
show subtarget assignments
)
1
in_crystallization_trials
No
Cj0883c
15792214
hypothetical protein Cj0883c [Campylobac...
136
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
2Y75
28.7%
Campylobacter jejuni
Energy metabolism
Electron transport
IDP02786
(
show subtarget assignments
)
1
purified
No
Cj0322
15791690
perR
FUR family transcriptional regulator [Ca...
136
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
2FE3
32.4%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP91449
(
show subtarget assignments
)
8
expressed
No
VV1_0390
27363858
SOS-response transcriptional repressor L...
137
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1I4V
34.3%
Vibrio vulnificus
IDP91313
(
show subtarget assignments
)
8
expressed
No
VP1661
28898435
putative LcrR [Vibrio parahaemolyticus R...
137
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP00848
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL1753
57286190
universal stress protein family
137
Conserved Gene / Pathway
Phase 2: March 2008
1MJH
33.5%
Staphylococcus aureus
Cellular processes
Adaptations to atypical conditions
IDP02534
(
show subtarget assignments
)
1
cloned
No
GBAA4614
47529912
Holliday junction resolvase-like protein...
137
Conserved;
Phase 3: June 2008
1VHX
70.8%
Bacillus anthracis
Hypothetical proteins
Conserved
IDP91014
(
show subtarget assignments
)
8
expressed
No
y2368
22126252
periplasmic protein [Yersinia pestis KIM...
137
other biological interest /
putative iron transport protein
Community Requests
3NRP
92.7%
Yersinia pestis
IDP02585
(
show subtarget assignments
)
1
purified
No
FTT1416c
56708463
lipoprotein [Francisella tularensis subs...
137
Drug Target
Phase 3: June 2008
Francisella tularensis
Cell envelope
Other
IDP90542
(
show subtarget assignments
)
8
in_pdb
3PJ9
No
Cj0332c
15791700
ndk
nucleoside diphosphate kinase [Campyloba...
137
Predicted Essential
Community Requests
3PJ9
100%
Campylobacter jejuni
IDP02584
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1301
16764652
pyrimidine (deoxy)nucleoside triphosphat...
138
Conserved; Drug target functions
Phase 3: June 2008
2RRK
75.4%
Salmonella enterica
Unknown function
General
IDP05580
(
show subtarget assignments
)
1
soluble
No
BA_0936
30254679
putative lipoprotein [Bacillus anthracis...
138
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP00870
(
show subtarget assignments
)
1
cloned
No
STM4470
16767715
yjgD
hypothetical protein STM4470
138
Conserved Gene / Pathway
Phase 2: March 2008
1NXI
54.3%
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP00095
(
show subtarget assignments
)
1
purified
No
NT01SF1278
30040854
flgN
flagella synthesis protein FlgN
138
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
Shigella flexneri
Cell envelope
Surface structures
IDP05090
(
show subtarget assignments
)
1
cloned
No
CD0230
126697801
putative flagellar biosynthesis protein ...
138
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP00875
(
show subtarget assignments
)
1
in_pdb
3G0M
No
STM1374
16764724
ynhA
cysteine desufuration protein SufE
138
Conserved Gene / Pathway
Phase 2: March 2008
3G0M
100%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP00040
(
show subtarget assignments
)
1
purified
No
BA_2042
46395770
Metallothiol transferase fosB 1 (Fosfomy...
138
Virulence
Phase 1: October 2007
3UH9
67.4%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP01540
(
show subtarget assignments
)
1
in_pdb
3EC6
No
GBAA0418
47525694
general stress protein 26 [Bacillus anth...
138
CONSERVED
Phase 3: June 2008
3EC6
100%
Bacillus anthracis
IDP91483
(
show subtarget assignments
)
8
cloned
No
VP1700
28898474
putative lipoprotein VirG [Vibrio paraha...
138
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP90175
(
show subtarget assignments
)
8
expressed
No
AAM13468.1
20153007
VGF
CPXV021 protein or CPXV VGF protein
139
similar to viral growth factor C11R vaccinia virus
Community Requests
1K36
15.8%
Cowpox virus
host range protein
0
IDP05737
(
show subtarget assignments
)
1
expressed
No
CD1990
126699598
hypothetical protein CD1990 [Clostridium...
139
virulence/pathogenesis /
Targets associated with virulence and/or pathogenesis
Phase 5: 2010
Clostridium difficile
Unknown function: General
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